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Tytuł oryginału: The response of the lymphatic system to the human skin resident bacteria.
Autorzy: Cakała M., Olszewski W. L.
Źródło: Ann. Transplant. 2002: 7 (4) s.30-35, il., tab., bibliogr. 6 poz.
Sygnatura GBL: 313,259

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • transplantologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: We designed a study to identify skin bacterial strains producing most intensive changes in lymphoid tissue of the draining nodes and analyse the node cell phenotypes reacting to bacterial antigens. The obtained results were expected to help in establishing rational therapy in recipients of hand allografts. The highest level of activation of lymphoid tissue was found after inoculation with S. epidermidis, Acinetobacter, Enterobacter and Aerococcus. There was an increase in weight and cell concentration of nodes, intense expression of W3/25 + (CD4), OX6+ (class II), EDI + (CD14), CD54 + OX62 + cells in the paracortex and medulla 7 days after bacterial inoculation. The most advanced changes were seen after recall bacterial stimulation. Taken together, evident differences in the intensity of response to the investigated bacterial strains were found. The obtained information can be useful for establishing rational antibiotic therapy after composite graft transplantation.

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