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Tytuł oryginału: Influence of diethyldithiocarbamate on the activity of ecto-ATPase in lymphocytes of rats: ex vivo studies.
Autorzy: Purzyc Leszek, Całkosiński Ireneusz, Polak-Jonkisz Dorota
Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.455-467, il., tab., bibliogr. 42 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Influence of diethyldithiocarbamate (DTC) on the activity of ecto-ATPase (plasma membrane-bound enzyme participating in a cascade of reactions leading to the formation of adenosine - a modulator of inflammation) was examined on the lymphocytes isolated from the spleen of rats with inflammation. DTC was administered at doses of 4 mg/kg and 290 mg/kg using two modes of administration. It has been observed that: a) an inflammation caused an increase in ecto-ATPase activity in both subpopulations of lymphocytes; in the case of B-lymphocytes, the maximum of activity occurred 48 h and in the cases of T-lymphocytes, 72 h after the injection of carrageenin; b) a single injection of DTC at boht doses, 24 h before or 24 h after carrageenin injection caused a decrease in ecto-ATPase activity in B-lymphocytes and its incresase in T-lymphocytes throughout the whole measurement period, which was not observed when DTG was administered only after provocation of inflammation; c) administration of a high dose of DTC togehter with equimolar doses of disulfiram and CS2 led to a decrease in ecto-ATPase activity and 5'-nucleotidase level in B-lymphocytes, which is bound to the former enzyme; d) in in vitro studies, both populations of lymphocytes isolated from the rats treated with a four-fold dose of DTC showed higher resistance of ecto-ATPase to inhibitors of the enzyme and antagonists of type P2 purinoceptors.

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