Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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Tytuł oryginału:
The influence of luteinizing hormone-releasing hormone analog on serum leptin and body composition in women with solitary uterine myoma.
Autorzy:
Nowicki
Michał,
Adamkiewicz
Grażyna,
Bryc
Władysław,
Kokot
Franciszek
Źródło:
Am. J. Obstet. Gynecol. 2002: 186 (3) s.340-344, il., tab., bibliogr. 25 poz.
Sygnatura GBL:
300,265
Hasła klasyfikacyjne GBL:
farmacja
ginekologia i położnictwo
onkologia
Typ dokumentu:
praca kliniczna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
płeć żeńska
Streszczenie angielskie:
Objective: The purpose of this study was to examine the influence of luteinizing hormone-releasing hormone analog goserelin on serum leptin and body composition in women with solitary uterine myoma. Study design: Fifteen women who were regularly menstruating and not obese were included. In all subjects, serum concentrations of leptin, insulin, testosterone, progesterone, and estradiol and body mass index and waist-to-hip ratio were measured before and after 4, 8, and 12 weeks of treatment with goserelin (3.6 mg every 4 weeks). Fat mass and lean body mass were measured by dual energy radiographic densitometry at baseline and after 12 weeks of therapy. Data were analyzed by multiple way analysis of variance and both simple and multiple regression. Results: The treatment caused a significant regression of myoma. Body weight, fat, ane lean mass were unchanged. No changes in plasma leptin (even after correction for fat mass) were noted during the treatment. Plasma estradiol decreased below castrate levels. Plasma progesterone decreased significantly, and testosterone tended to decline during the study. At baseline a highly significant positive correlation was found between serum leptin and fat mass. In a multiple regression analysis, neither the change in fat mass nor any of the hormonal parameters explained the significant portion of variance of plasma leptin during the treatment. Conclusion: Pharmacologic gonadectomy does not influence plasma leptin concentrations in women if body fat mass is unchanged.
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