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BRUCHAJZER
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Tytuł oryginału:
Acute and subacute nephrotoxicity of 2-bromophenol in rats.
Autorzy:
Bruchajzer
Elżbieta,
Szymańska
Jadwiga A.,
Piotrowski
Jerzy K.
Źródło:
Toxicol. Lett. 2002: 134 (1/3) s.245-252, il., tab., bibliogr. [24] poz.
Sygnatura GBL:
306,158
Hasła klasyfikacyjne GBL:
toksykologia
farmacja
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć żeńska
Streszczenie angielskie:
The present report aims at providing broader information on the acute nephrotoxicity of 2-bromophenol (2-BP) (a bromobenzene (BB) metabolite), due to its action on the kidneys, after repeated administration. Investigations were performed on female rats. Following a single dose, the most pronounced changes involved: concentrations and rates of excretion of proteins in urinwe, the number of epithelial cells excreted in urine, creatinine and urea clearance and reduced gluthione in renal tissue. Immediate effects could be ascribed to both renal tubules and glomeruli, mirrored in the level of urinary proteins and intensified excretion of renal epithelial cells. Less pronounced changes of the indicator values were noted under repeated dosing of 2-BP. The results obtained in a single exposure study confirm earlier on the mild nephrotoxicity of 2-BP following exposure to high doses. However, the transition from single to repeated expopsure does not result in enhanced nephrotoxicity.
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