Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
BROWN
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8
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1/8
Tytuł oryginału:
Surgical view of the treatment of patients with hepatoblastoma. Results from the First Prospective Trial of the International Society of Pediatric Oncology Liver Tumor Study Group (SIOPEL-1).
Autorzy:
Schnater
J. Marco,
Aronson
Danil C.,
Plaschkes
Jack,
Perilongo
Giorgio,
Brown
Julia,
Otte
Jean-Bernard,
Brugieres
Laurences,
Czauderna
Piotr,
MacKinlay
Gordon,
Vos
Anton
Źródło:
Cancer 2002: 94 (4) s.1111-1120, il., tab., bibliogr. 20 poz.
Sygnatura GBL:
311,015
Hasła klasyfikacyjne GBL:
pediatria
gastroenterologia
onkologia
Typ dokumentu:
praca kliniczna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
Background. Surgical resection is the cornerstone of treatment for patients with hepatoblastoma (HB). The Society of Pediatric Oncology Liver Tumor Study Group launched its first prospective trial (SIOPEL-1) with the intention to treat all patients with preoperative chemotherapy and delayed surgical resection. The objective of this article was to assess the assumed surgical advantages of primary chemotherapy. Methods. Between 1990 and 1994, 154 patients age 16 years with HB were registered on SIOPEL-1. The pretreatment extent of disease was assessed, and, after undergoing biopsy, patients were treated with cisplatin 80 mg/mý intravenously over 24 hours and doxorubicin 60 mg/mý intravenously over 48 hours by continuous infusion (PLADO). Generally, tumors were resected after four of a total of six courses of PLADO. Results. One hundred twenty eight patients underwent surgical resection (13 patients underwent primary surgery, and 115 patients underwent delayed surgery after PLADO). A pretreatment surgical biopsy was performed in 96 of 128 patients (75 p.c.). Biopsy complications occurred in 7 of 96 patients (7 p.c.). Twenty-two patients showed pulmonary metastases at the time of diagnosis, and 7 patients underwent thoracotomy. Operative morbidity and mortality were 18 p.c. and 5 p.c., respectively. Complete macroscopic surgical resection was achieved in 106 patients (92 p.c.), including 6 patients who underwent orthotopic liver transplantation. The actuarial 5-year event free survival (EFS) rate for all 154 patients in the study was 66 p.c., and the overall survival (OS) rate was (75 p.c.)...
2/8
Tytuł oryginału:
Long-term changes in calbindin D28K immunoreactivity in the rat hippocampus after cardiac arrest.
Autorzy:
Sadowski
Marcin,
Lazarewicz
Jerzy W.,
Jakubowska-Sadowska
Katarzyna,
Wiśniewski
Henryk M.,
Mossakowski
Mirosław J.,
Brown
W. Ted
Źródło:
Neurosci. Lett. 2002: 321 (1/2) s.90-94, il., bibliogr. 20 poz.
Sygnatura GBL:
305,936
Hasła klasyfikacyjne GBL:
kardiologia
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
Streszczenie angielskie:
Calbindin D28K (CB) expression was analyzed in the rat hippocampus following 10-min-cardiac arrest-induced ischemia within a year after reperfusion. In rats examined 3 days after ischemia, CB immunoreactivity disappeared completely from CA1 pyramidal neurons and from most CA2 pyramids. In the stratum granulosum of the dentate gyrus, mossy fibers, and hippocampal interneurons, CB immunoreactively was preserved, although staining was somewhat paler than that in control rats. A similar pattern of CB immunoreactively was found in rats sacrificed 14 days and 1 month after cardiac arrest. From the 14th postischemic day, neuronal loss in the stratum pyramidale of CA1 but not in that of CA2 became apparent. The reappearance of CB immunoreactivity in CA1 and CA2 pyramidal neurons was noticed 6 months after ischemia, and the pattern was identical to that observed in animals sacrificed 12 months after the octus. The prolonged loss and delayed reappearance of CB immunoreactivity in the hippocampus demonstrate that ischemia may induce long-term disturbances of protein expression, which may in turn result in impairment of hippocampal functioning.
3/8
Tytuł oryginału:
Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 1: Alterations of myelinated axons.
Autorzy:
Liberski
Paweł P.,
Bratosiewicz-Wąsik
Jolanta,
Gajdusek
D. Carleton,
Brown
Paul
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.121-129, il., bibliogr. s. 127-129
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Streszczenie angielskie:
Classical and ultrastructural neuropathology of prion diseases are generally well described. Here we report that alternations of myelinated fibres in hamsters infected either with polioencephalopathic strains of scrapie or panencephalopathic strains of CJD (Echigo-1) are virtually identical and differ only quantitatively. In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres.
4/8
Tytuł oryginału:
Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 2: Astrocytic and macrophage reaction towards axonal destruction.
Autorzy:
Liberski
Paweł P.,
Bratosiewicz-Wąsik
Jolanta,
Gajdusek
D. Carleton,
Brown
Paul
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.131-139, il., bibliogr. s. 137-139
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Świnki morskie
Streszczenie angielskie:
We report hare the microglial (macrophage) and astrocytic reaction in several models of transmissible spongiform encephalopathies (TSEs) or prion diseases. With the low power electron microscopy it was readily apparent that myelinated vacuoles were surrounded by cells and their processes. The latter belonged either to hyperplastic reactive astrocytes or to macrophages. Typically, reactive astrocytes exhibited cytoplasm filled with innumerable glial filaments and, occasionally, other organelles (like cilia) and abundant tortuous intercellular junctions of adhesive plaque junction type. Desmosome-like junctions connecting astrocytic elements were also seen. As described earlier, astrocytic process were occasionally interdigitated with oligodendroglial cells and their processes. Two types of macrophages were readily described. The majority of them exhibited electron-dense cytoplasm and numerous "empty" vacuoles (digestive chambers) containing cellular debris. Occasional vacuoles were surrounded by a thin collar reminiscent of "lyre-like inclusions" of the second type of macrophages. Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae.
5/8
Tytuł oryginału:
How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited.
Autorzy:
Liberski
Paweł P.,
Gajdusek
D. Carleton,
Brown
Paul
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.141-147, il., bibliogr. s. 145-147
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Streszczenie angielskie:
As in other neurodegenerative diseases such as Alzheimer's disease, neurons in prion diseases or transmisible spongiform encephalopathies (TSEs) die via programmed cell death of which the apoptotic process is relatively well characterized. A subcellular alteration linked to apoptosis is the formation of autophagic vacuoles, which we and others demonstrated in CJD- and scrapie-affected rodent brains. Autophagy may co-exist with apoptosis or may precede it and the process may be induced by apoptosis stimuli. Here, we extend these observations using different model of scrapie and CJD. Both scrapie models (the 265K and 22C-H) demonstrated autophagic vacuoles with the same frequency; hence, they will be described together. While the following changes had been observed simultaneously in different areas of the same sample, this description is organised as if it followed a sequence of events. First, a part of the neuronal cytoplasm was sequestrated by concentric arrays of membrane; that part of the cytoplasm closed by membranes appeared relatively normal but its density often appeared increased. Next, electron density of the central dramatically increased. Then, membranes proliferated within the cytoplasm in a labyrinth-like manner and an area sequestrated by these membranes enlarged and became more complex structure consisting of vacuoles, electron-dense area and areas of normally-looking cytoplasm connected with convoluted membranes. Finally, a large area of the cytoplasm was transformed into a collection of autophagic vascuoles of different sizes. Virtually identical alternations, albeit with much lower frequency, were seen in terminally ill CJD-affected hansters.
6/8
Tytuł oryginału:
Patient, community and clinician perceptions of the quality of life associated with diabetes mellitus.
Autorzy:
Landy
Jennifer,
Stein
Joshua D.,
Brown
Melissa M.,
Brown
Gary C.,
Sharma
Sanjay
Źródło:
Med. Sci. Monitor 2002: 8 (8) s.CR543-CR548, tab., bibliogr. 27 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
endokrynologia
Typ dokumentu:
praca epidemiologiczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
Background: A study was undertaken to assess the quality of life of patients with type 1 and type 2 diabetes mellitus and to ascertain whether clinicians and non-diabetic respondents from the general public have similar views of the impact of diabetes upon health-related quality of life. Material/Methods: Time trade off utility values were generated from a standardized time-tradeoff questionnaire. Three hundred and fifty-two individuals with type 1 or type 2 diabetes mellitus, 157 non-diabetic participants from the general public (community), and 61 healt care clinicians participated in the study. Results: The mean utility score for diabetic patients was 0.889 and the median utility score was 1.000. The mean utility score for clinicians was 0.861, with a median value of 0.894, while the respective mean and median scores for the general public were 0.919 and 0.953. There was a significant difference between the disribution of the means of socres of clinicians and patients as well as between clinicians and the general public. There was no significant difference between the utility scores of patients and the general public. Within the group of diabetic patients, there was no significant difference in utility scores between type 1 and type 2 diabetics. Conclusions: Clinicians tended to over emphasize the impact that diabetes mellitus has on health related quality of life, while the non-diabetic publics' utility values are more closely correlated with those of diabetics themselves. We conclude that there is a significant difference in how clinicians, diabetics and the general public perceive the effect diabetes has upon quality of life.
7/8
Tytuł oryginału:
Funding, objectivity and the socialization of medical research.
Autorzy:
Brown
James Robert
Źródło:
Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.295-308, bibliogr. 14 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
Sygnatura GBL:
735,647
Typ dokumentu:
praca związana ze zjazdem
tytuł obcojęzyczny
praca przeglądowa
8/8
Tytuł oryginału:
Agonists of peroxisome-proliferator activated receptor-ŕ (Clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.
Autorzy:
Sivarajah
Ahila,
Chatterjee
Prabal K.,
Hattori
Yoshiyuki,
Brown
Paul A. J.,
Stewart
Keith N.,
Todorovic
Zoran,
Mota-Filipe
Helder,
Thiemermann
Christoph
Źródło:
Med. Sci. Monitor 2002: 8 (12) s.BR532-BR539, il., tab., bibliogr. 37 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
farmacja
nefrologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie angielskie:
Background: The aim of this study was to investigate the effects of peroxisome-proliferator activated receptor-ŕ (PPAR-ŕ) agonsits, clofibrate and WY 14643 on the renal dysfunction and injury caused by bilateral ischemia/reperfusion (I/R) of rat kidneys in vivo. Material/Methods: Male Wistar were randomized with sodium thiopentone (120 mg/kg i.v.) and subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h). Serum and urinary biochemical indicators of renal dysfunction and injury were meausured; serum creatine (sCr, glomerular dysfunction), fractional excretion of Na+ (FE NA, tubular dysfunction), and urinary N-acetyl-á-D-glucosaminidase (uNAG, tubular injury). Additionally, renal sections were used for histological grading of renal injury and for RT-PCR analysis of the expression of PPAR-isoforms in kidneys obtained from rats prior to or after I/R. In addition, expression of intercellular adhesion molecule-1 (ICAM-1) was determined using Northern blot analysis. Results: Using RT-PCR we document here the expression of PPAR-ŕ, PPAR-á and PPAR-ç1 (but not PPAR-ç2) in the kidney of the rat. I/R resulted in the down-regulation of PPAR-ŕ without modulation of any other PPAR. Clofibrate and WY 14643 significantly reduced the increases in sCr, FE NA and uNAG caused by renal I/R, indicating attenuation of renal dysfunction and injury. Expression of ICAM-1 caused by I/R of the kidney was not modulated by PPAR-ŕ agonists. Conclusions: We show here that (i) renal I/R results in the down-regulation of PPAR-ŕ in the kidney, and (ii) that the PPAR-ŕ agonists...
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