Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: BROJER
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Analysis of HLA frequencies in donor population of Unrelated Bone Marrow Donor and Cord Blood Registry of Institute of Haematology and Blood Transfusion.
Autorzy: Nowak Jacek, Gronkowska Anna, Brojer Ewa
Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.97-115, tab., bibliogr. 26 poz.
Sygnatura GBL: 313,243

Hasła klasyfikacyjne GBL:
  • immunologia
  • genetyka
  • hematologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The HLA alleles and haplotypes frequencies of Polish population are helpful in the routine work of HLA laboratory and in searching of underlated bone marrow donors for Polish patients. HLA I class typing was performed by standard serological method in 2580 potential donors from Poland, and HLA DRB1 DNA typing by PCR-SSP or PCR-SSOP at low resolution level in 386 donors chosen by chance from the said population. Allelic and haplotypic (2 or 3 loci haplotype) gene frequencies were estimated by iterative maximum likelihood gene counting method suplemented by expectation maximization and Hardy-Weinberg equilibrium algorithm using ML-EM-HW v. 5.2 software elaborated in our Institute. The resolution of used methods was: 24 specifies of HLA-A, 46 HLA-B, 11 HLA-Cw, and 17 HLA*DRBI. There was a different portion of HLA "blank" in each locus. Allele gene frequencies were comparable with other Central Europe population frequencies. Estimated and observed antigen phenotypic frequencies were very similar. Fit to Hardy-Weinberg equilibrium was tested by Xý test foreach locus separately and was good (p=1.0000). The highest positive linkage was found in following two-locus haplotypes: A*01-B*08 (GF 0.0739, delta 0.0613, p 0.0001), A*03-B*07 (GF 0.0504, delta 0.0333, p 0.0001) and A*25-B*18 (GF 0.0334, delta 0.0288, p 0.0001). Very high, but negative linkage was found for A*02-B*08 (GF 0,0075, delta-0.0215, p 0.0001) and A*01-B*18 (GF 0.0010, delta-0.0095, p 0.0001) two locus halotypes. Sixteen HLA-A-B-DRBI there-locus haplotypes showed gene frequency...

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    Tytuł oryginału: HLA DRB1 alleles in HCV RNA positive patients with and without anti-HCV antibodies: relationship with the outcome of infections.
    Autorzy: Brojer Ewa, Kryczka Wiesław, Kalińska Aleksandra, Medyńska Joanna, Żupańska Barbara
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.53-57, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In some individuals infected with HCV, the anti-HCV is not detectable and HCV RNA is the only marker of the infection. Since the formation of certain antibodies is MHC restricted, we evaluated whether there are differences in the HLA DRB1 allele frequency between anti-HCV negative and positive hepatitis patients, and whether the DRB1 frequency difers between patients with self-limited and chronic infection. Material: 167 HCVRNA positive (37 anti-HCV negative to end of follow-up) patients, including 42 with acute hepatitis and 125 chronic hepatitis patients; control group of 286 healthy individuals. After the follow-up for at leats 30 months the patients were divided into 2 groups: those with self-limited and those with chronic hepatitis. Other reasons of hepatitis and obvious immune defects were excluded. Methods: HCV RNA by RT PCR, antiHCV by the third generation EIA; DRB1 by INNOLiPA DRB1. Results: We found no difference in the frequency of DRB1 alleles between the healthy individuals and HCV infected patients nor between the anti-HCV negative and positive patients. However, the frequency of DRB1*15 and DRB1*11 observed in the patients with self-limited infection was significantly higher than that in the patients with chronic infection. This difference was independent of anti-HCV delectability.

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    Tytuł oryginału: Poszukiwanie rodzinnego dawcy szpiku dla chorych nie posiadających zgodnego w HLA rodzeństwa.
    Tytuł angielski: Strategy of marrow donor search among family members for the patients who do not have a matched sibling.
    Autorzy: Nowak Jacek, Gronkowska Anna, Brojer Ewa
    Źródło: Acta Haematol. Pol. 2002: 33 (3) s.309-316, il., tab., bibliogr. 11 poz., sum.
    Sygnatura GBL: 305,450

    Hasła klasyfikacyjne GBL:
  • hematologia
  • transplantologia
  • genetyka
  • immunologia

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy omówiono możliwości doboru i zasady wykonywania badań HLA w przypadkach rodzinnych dawców szpiku, innych niż rodzeństwo (rodzice i członkowie rozszerzonej rodziny). Dla ilustracji przytoczono obserwacje własne dotyczące specyfiki doboru rodziców, a także analizę rodzin, w których zaobserwowano zjawisko crossing over zasadniczo zmieniające sposób interpretacji rodzinnych danych HLA.

    Streszczenie angielskie: HLA typing and match strategy of potential non-sibling family donors for patients who do not have matched sibling is discussed. We also present our experience in parental matching, the analysis of families with crossover recombination within the HLA region and the way of its interpretation.

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