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Tytuł oryginału: Repeated intravenous doses of all-trans-retinoyl á-D-glucuronide is not effective in the treatment of bacterial bronchopneumonia in lambs but is devoid of gross and acute toxicity.
Autorzy: Gallup Jacek M., Grubor Branka, Barua Arun B., Mohammadi Gholamreza, Brogden Kim A., Olson James A., Ackermann Mark R.
Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR345-BR353, il., tab., bibliogr. 55 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • weterynaria
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: All-trans-retinoyl á-D-glucuronide, a water-soluble glucuronic acid conjugate of all-transretinoic acid, has demonstrated high biolobical activity and low toxicity in most in vitro and in vivo models. Since the reparative effects of retinoids on epithelium are well-known, our aim was to study the effect(s) of intravenously-administered all-trans-retinoyl á-D-glucuronide in lambs with chronic bacterial bronchopneumonia. Material/methods: Two groups of lambs were inoculated intrabronchially with either pyrogen-free saline or Mannheimia haemolytica. Thirty-three days later, lambs were injected four times at five-day intervals with 2 mL of 116 mM all-trans-retinoyl á-D-glucuronide (6.0-9.3 ćmol/kg or 2.86 - 4.42 mg/kg animal body weight) in dimethyl sulfoxide, or dimethyl sufoxide alone. Animal behavior and signs of clinical illness were logged daily. Lung and liver samples were assessed for histophatology, while serum and liver samples were extracted for retinoids and analyzed by reversed-phase gradient high-performance liquid chromatography. Results: Repeated injections of hibhly concentrated all-trans-retinoyl á-D-glucuronide did not cause changes in appetite, activity or other behaviors nor did it cause histologic lesions in liver and lung. However, it had no effect on resolution of lung lesions resultant of chronic Mannheimie haemolytica bronchopneumonia. Conclusion: Repeated intravenous administration of high amounts of all-trans-retinoyl á-D-glucuronide to lambs did not elicit signs of gross or microscopic toxicity. However, administering all-transretinoyl á-D-glucuronide too late in the progression of bacterial pneumonia is thought to be the main reson for its lack of effect in this model. A retinoid lactone derivative was detected in sheep serum and liver several days after treatment.

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