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Tytuł oryginału: Chronic graft-versus-host disease and its management in children.
Autorzy: Vossen J. M., Breedeveld L., Bakker J. D. J., Mertens B., Well-Sipman M. H. van
Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (4) s.133-138, tab., bibliogr. 19 poz.
Sygnatura GBL: 313,406

Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Chronic graft-versus-host disease is sometimes a severe, disabling and long-lasting complication of allogeneic hematopoietic stem cell transplantation. Its frequency lies between 10 and 40 p.c. of pediatric graft recipients, depending on a number of risk factors. Such factors are the type, i.e. HLA-identical related or not, gender and age of the stem cell transplant donor, original diagnosis of the patient and, most importantly, the occurrence or not of a prior acute graft-versus-host disease. Chronic graft-versus-host disease manifests itself as a collagen vascular autoimmune disease. Its treatment consists of immuno-modulatory and antiinfections drugs, in addition to supportive care and psycho-social support. Medical treatment demands a tailor-made approach and careful and prolonged surveillance.

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