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Zapytanie: BOSSOWSKI
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Tytuł oryginału: Expression of very late antigen-4 and lymphocyte function-associated antigen-1 on peripheral blood lymphocytes from patients with graves disease.
Autorzy: Bossowski Artur, Urban Mirosława, Stasiak-Barmuta Anna, Turowski Dariusz
Źródło: Pediatr. Res. 2002: 52 (4) s.533-537, il., bibliogr. 31 poz.
Sygnatura GBL: 300,504

Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the syudy was to estimate the expression of á1 integrin CD49d (very antigen-4), á2 integrin CD11a (lymphocyte function-associated antigen 1 alpha), l-selectin (CD62L), and intercellular adhesion molecule-1 [ICAM-1 (CD54)] on peripheral blood mononuclear cells in patients with Graves disease (GD0 (n = 45, mean age 15.9 ń 5.9 y), in patients with nontoxic nodular goiter (NTNG) (n = 25, mean age 15.2 ń 5.7 y), and in sex- and age-matched healthy control subjects (n = 25, mean age 15.9 ń 2.4 y). The expression of the lymphocyte adhesion molecules was analyzed by three-color flow cytometry. decreased percentages of CD49d+ and CD11a+ lymphocytes were observed in untreated Graves' patients in comparison to healthy controls (p 0.007, p 0.036) and non-toxic nodular goiter patients (p 0.006, p 0.019). The analysis of CD62L+ and CD54+ antigen expression on peripheral blood lymphocytes revealed increased percentages of L-selectin- and ICAM-1-positive cells in patients with GD (p 0.005 for CD62L, p 0.008 for ICAM-1) before methimazole therapy, compared with healthy controls. These abnormalities were absent in children with NTNG. In patients with unterated GD, a positive correlation was found between serum levels of free thyroxine and the percentage of CD54+ lymphocytes (r = 0.47, p 0.036). Statistically significant negative correlations existed between free tyroxine concentration in blood serum and the percentage of CD11a+ lymphocytes (r = -0.39,p 0.033). No such correlation was detected between the percentage of lymphocyte markers and serum levels of antithyroid antibodies...

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