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Tytuł oryginału: Glioblastoma multiforme following Bragg proton beam radiosurgery for cerebral arteriovenous malformation: complication or association?
Autorzy: Ritz Rainer, Freudenstein Dirk, Bhring Udo, Krth Ulrich, Bornemann Antje, Duffner Frank
Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.219-223, il., bibliogr. 30 poz.
Sygnatura GBL: 313,612

Hasła klasyfikacyjne GBL:
  • chirurgia
  • neurologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: Stereotactic radiosurgery has become a widespread treatment alternative especially in benign centrakl nervous system lesions. So far, only a few cases of photon beam radiosurgery-induced oncogenesis have been reported. Case report: The authors report a patient who underwent Bragg proton beam radiosurgery through two bi-occipital portals for a surgically inaccessible left-sided occipital high-flow arteriovenous malformation (AVM). 19 years after irradiation, ther patient developed a mild left-sided hemiparesis together wity a progressive change of his mental status. Magnetic resonance imaging (MRI) demonstrated a predominantely cystic fronto-polar lesion on the right side. Neuropathological investigation after microsurgical resection revealed a glioblastoma multiforme (WHO IVú). Based on a through review of the literature, this constellation had not been described previously. Conclusions: Despite the common use of stereotactic radiosurgery in any application, the risk of delayed cerebral neoplasia reported to occur after fractionated irradiation still remains to be clarified. In the presented case, the caused relationship between proton beam radiosurgery and formation of a malignant brain tumors is discussed.

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