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Tytuł oryginału: Intermediate endpoints in the molecular epidemiology of cancer.
Autorzy: Bonassi Stefano
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.347-353, tab., bibliogr. 17 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Intermediate endpoints of cancer (IEC) are those events that can be used to antipicate the clinical diagnosis of the disease. An alteration or an increase over the background frequency of these biomarkers allows estimating the risk of cancer development, since they generally lie on the pathway leading from the initiation of the neoplastic process to the occurrence of invasive cancer. Given the key role in public health and the potential use of this information to predict the development of disease and to implement disease prevention programs a special consideration should be given to the validation process of intermediate endopoints. Among biomarkers considered as candidate IEC, good theoretical evidence and a number of epidemiological prospective studies supports the evidence that chromosome aberrations measured in lymphocytes of healthy individuals are predictive of cancer risk. Appying the figures estimated by these studies, the proportion of cancers that could be attributed to an increase in the frequency of chromosomal aberrations was evaluated to be 23-24 p.c. The estimation of cancer risk in astronauts after space missions was reported as an exmple of how this information can be in risk assessment.

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