Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: BOCHEŃSKI
Liczba odnalezionych rekordów: 2

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Tytuł oryginału: Nowa strategia leczenia trądzika pospolitego.
Tytuł angielski: New strategy of acne treatment.
Autorzy: Langner Andrzej, Ambroziak Marcin, Bocheński Jacek
Źródło: Ter. Leki 2002: 52 (3) s.18-21, il., bibliogr. 6 poz., sum.
Sygnatura GBL: 313,514

Hasła klasyfikacyjne GBL:
  • farmacja
  • dermatologia i wenerologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The paper presents the latest data on pathogenesis and evaluation of acne lesions. Based on these knowledge the authors suggested routine ways of treatment in acne vulgaris, especially its inflammatory from, which reffers to most acne patients. It seems that use of topical retinoids in combination with antimicrobial agents is the most reasonable methods of treatment. It allows to eliminate all of pathogenetic factors observed in acne vulgaris. The efficacy of this type of treatment was confirmed not only by worldwide studies but also our own experience with results given below. Further treatment should consist of prolonged use of topical retinoids in order to prevent exacerbation of acne.


    Tytuł oryginału: Recombinant human activated protein C for severe sepsis in a neonate.
    Autorzy: Rawicz Marcin, Sitkowska Bożena, Rudzińska Iwona, Kornacka Katarzyna M., Bocheński Przemysław
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CS90-CS94, il., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Background: Neonatal sepsis is frequently associated with pathological activation of the coagulation system, leading to multiple organ dysfunciton. Activated protein C has been shown to prevent thrombin generation durign this process and improve microcirculation. Case report: We present the case of a full term septic neonate admitted for tertiary intensive care with multiple organ failrue, including ARDS with severe pulmonary hypertension, renal failure, and disseminated intravascular coagulation. After initial resuscitation with volume expansion, catecholamines, pentoxifylline and nitric oxide, a diagnosis of severe systemic enterococcal sepsis was made and vancomycin-meropenem therapy was started. Because available standard treatment, including platelet transfusion, did not improve the coagulation status, it was decided to give recombinant human activated protein C (drotrecogin alpha Xigris, Elli Lilly, USA - rhAPC) in 24 mcg kg-1úh-1 continuous four-day infusion. Six hours after the start of infusion all coagulation parameters returned to normal. No side effects were observed. Renal function was restored after 36-hr hemofiltration. Treatment success was due to several factors, including resuscitiation form cardiogenic shock, effective antibiotic therapy, hemofiltration, and combined rhAPC-pentoxifylline therapy. Conclusions: The postiive outcome of this case indicates that rhAPC can be safely used in infants. A largescale study of the effectiveness of drotrecogin alpha in pediatric population is indicated.

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