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BLANCK
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Tytuł oryginału:
Components of the IFN-ç signaling pathway in tumorigenesis.
Autorzy:
Blanck
George
Źródło:
Arch. Immunol. Ther. Exp. 2002: 50 (3) s.151-158, il., bibliogr. 78 poz.
Sygnatura GBL:
304,223
Hasła klasyfikacyjne GBL:
immunologia
onkologia
Typ dokumentu:
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
zwierzęta
myszy
in vitro
Streszczenie angielskie:
Many features of the interferon ç (IFN-ç) signaling pathway would suggest that it is anti-tumorigenic. The IFN-ç signaling pathway leads to apoptosis and to the expression of immune function proteins that could cooperate with T cells in the destruction of tumor. Various lines of experimental approach have, in general, supported the hypothesis that the IFN-ç signaling pathway is anti-tumorigenic. However, data also indicate that the idea that the IFN-ç signaling pathway is exclusively anti-tumorigenic is too simplastic. Also, to date, very ;ittle of the knowledge regarding the anti-tumor effects of the IFN-ç pathway has been useful in the prognosis or therapy of cancer. This review summarize the current state of knowledge regarding the IFN-ç signaling pathway in tumorigenesis, with an emphasis on MHC class II induction in tumor cells and the induction of apoptosis in tumor cells. The review also indicates some future areas of investigation that offer hope for applying this knowledge in reducing cancer nortality.
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