Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: BENSON
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Tytuł oryginału: Stress in cardiovascular diseases.
Autorzy: Esch Tobias, Stefano George B., Fricchione Gregory L., Benson Herbert
Źródło: Med. Sci. Monitor 2002: 8 (5) s.RA93-RA101, il., bibliogr. 85 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Evidence for a connection between stress and selected cardiovascular diseases is analyzed. Does stress cause or exacerbate cardiovascular diseases? The stress phenomenon is illustrated and the impact of stress on the circulatory system is examined. In particular, the pathophysiological significance of stress in hypertension, atherosclerosis, coronary artery disease, myocardial infarction (and others) is described. Stress plays a major role in various (pathophysiological processes associated with the circulatory system. Thereby, it potentially has ameliorating or detrimental capacities. However, with regard to cardiovascular disease, stress most often is related to deleterious results. The specific outcome depends on multiple variables (amount of stress, duration of is influence, patient's history/predisposition, genetic components - as they all may after functions of the basic stress response components: the hypothalmic-pituitary-adrenal axis and the sympathoadrenal medullary system). Stress has a major impact upon the circulatory system. It plays a significant role in susceptibility, progess, and outcome of cardiovascular diseases. Subjective or individual differences have also to abe taken into account. Stress, especially 'adequate'acute stress - stress that is not 'overwhelming' - may improve performance and thus be beneficial in certain cases. The close relationship between stress and cardiovascular diseases may represent an important aspect of modern medicine. New therapeutic strategies have to be set in place.

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    Tytuł oryginału: Stress-related diseases - a potential role for nitric oxide.
    Autorzy: Esch Tobias, Stefano George B., Fricchione Gregory L., Benson Herbert
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA103-RA118, tab., bibliogr. 195 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Nitric oxide (NO) is involved in stress physiology and stress-related disease processes. Like stress, NO seems to be capable of principally exerting either beneficial or deleterious effects. The actual distinction depends on a multitude of factors. Moreover, NO conteracts norepinephrine (NE) activity and sympathetic responsivity. Thus, NO and the stress (patho)physiology are closely connected ad molecular mechanisms or pathways may be shared under certain conditions. NO is involved in immunological, cardiovascular, and neurodegenerative diseases/mental disorders. It represents a 'double-edged sword', since small quantities produced by constitutive enzymes may predominantly mediate physiological effects, whereas the expression of inducible NO synthases may lead to larger quantities of NO, a situation that may be associated with cytotoxic and detrimental effect of NO. The key step for normally useful physiological mechanisms beacoming pathophysiological may be represented by the loss of balance, the loss of control over the different pathways induced. A failure to terminate or shift originally protective mechanisms may lead to a vicious cycle of disease-supporting pathophysiological pathways. Profound connections between stress and various disease processe exist. Thereby, common pathophysiological pathways in stress-related diseases have been described, ant they involve stress hormone (cortisol, NE) and, in particular, NO activity. Thus, NO has detrimental capacities. However, NO not only exerts deleterious but also strongly ameliorating effects. The balance between both properties is crucial. Yet, nitric oxide involvement in stress-related disease represents a common pathway, with various pathophysiogical analogies, that may be accessible for strategies using stress mangement and relaxation response techniques.

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