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Tytuł oryginału: Risk assessment and human exposure to endocrine disrupters.
Autorzy: Bencko Vladimir
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.295-305, il., tab., bibliogr. 22 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska
  • onkologia
  • endokrynologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Human exposure to endocrine disrupters (EDs) is widespread and is considered to pose a growing threat to human health. Recent advances in molecular and genetic research and better understanding of mechanisms of blastic cell transformation have led to efforts to improve cancer risk assessment for populations exposed to this family of xenobiotics. In risk assessment, low dose extrapolation of cancer incidence data from experimental animals and epidemiology studies has been largely on models assuming linear correlation at low doses, despite existence of evidence showing othervise. Another weakness of ED risk assessment is poor exposure data in ecological studies. Those are frequently rough estimates derived from contaminated items of local food basket surveys. Polyhalogenated hydrocarbons and arsenic are treated as examples. These is growing sense of urgency to develop a biologically based dose response model of cancer risk, integrating emerging data from molecular biology epidemiology to provide more realistic data for risk assessors, public health managers and environmental issues administrators.

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