Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: BASSO
Liczba odnalezionych rekordów: 2



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku
1/2

Tytuł oryginału: Experimental Chagas'disease: the protection induced by immunization with Trypanosoma rangeli is associated with down-regulation of IL-6, TNF-ŕ and IL-10 synthesis.
Autorzy: Cervetta Liliana, Moretti Edgardo, Basso Beatriz
Źródło: Acta Parasitol. 2002: 47 (1) s.73-78, il., bibliogr. [36] poz.
Sygnatura GBL: 303,018

Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In an experimental model developed in our laboratory, BALB/c mice were protected against Trypanosoma cruzi infection by immunization with T. rangeli, a parasite closely related to T. cruzi but not pathogenic for man. Immunized mice developed low parasitemia and high survival rates when challenged with T. cruzi. In the present work, we study the patterns of systemic production of interleukin (IL-6), tumor necrosis factor alfa (TNF-ŕ), interferon gamma (IFN-ç), IL-2, IL-4 and IL-10 during the acute phase of T. cruzi infection in mice previously immunized with T. rangeli with respect with respect to only infected mice. The results showed a concentration of IL-6, TNF-ŕ and il-10 significantly lower in immunized mice than in only infected ones. The production of IFN-ç, a cytokine involved in resistance, was preserved in vaccinated mice. Finally, both groups of animals showed IL-2 and IL-4 serum levels similar to those observed in uninfected mice. As in other experimental or human infections, in this model, the pattern of systemic production of cytokines can be associated with the outcome of infection.

    2/2

    Tytuł oryginału: Human cytomegalovirus infection and abortion: an immunohistochemical study.
    Autorzy: Spano Liliana Cruz, Pereira Fausto Edmundo Lima, Basso Nadia Gomes da Silva, Mercon-de-Vargas Paulo Roberto
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR230-BR235, il., tab., bibliogr. 50 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cytomegalovirus (HCMV) has been described in abortion tissues, but seldom associated with inclusion bodies. However, the possible pathogenic role of this virus in aborton is under discussion. We attempted to verify the realtionship between HCMV antigens in tissues from first trimester abortions presenting with inflammatory lesions. Sixteen cases of first trimester abortions with inflammatory lesions were selected from 340 cases studied at the Pathology Unit of the University Hostoptal in Vitória, Espirito Santo State, Brazil. Paraffin-embedded sections were subjected to indirect immunofluorescence (IFI) and immunoperoxidase (PAP), using monoclonal antibodies directed against immediate early (IEA) and late antigens (LA) of HCMV. Twelve out of sixteen cases (75 p.c.) presented at least one HCMV antigen. Eight cases presented both antigens, three cases only the IEA and one case only the LA. These antigens were present in decidual cells, in stromal cells of chorionic villi and in trophoblastic cells. The results showed high frequency of HCMV antigens in tissues from first trimester abortion. This frequency, higher than that previously reported, was probably due to the fact that necroinflammatory lesions were always present in selected cases. The presence of LA in trophoblastic cells is evnce for cell permissiveness to viral replication in vivo. The results showing high presence of HCMV antigens in tissues from abortion with inflammatory lesions suggest a possible relationship of HCMV infection with inflammation and pregnancy loss.

    stosując format: