Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Fluoxetine differentially suppresses sucrose solution consumption of free-fed and food-deprived rats - reversal by amantadine.
Autorzy: Prendergast Mark A., Yells David P., Balogh Scott E., Paige Stephen R., Hendricks Shelton E.
Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR385-BR390, il., bibliogr. 36 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • toksykologia
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Clinical use of fluoxetine and similar medications is often associated with appetite suppression and weight loss that may warrant drug discontinuation. It is unclear, however, if fluoxetine induced consummatory suppression may be influenced by factors such as dietary status and if appetite suppressant effects of fluoxetine may be pharmacologically attenuated. Material/Methods: Fluoxetine (0.5 - 10 mg/kg, i.p.) was administered to free-fed and 24 hr food-deprived adult male rats either 30 min or 4 hr prior to presentation of a sucrose solution (10 p.c. v/v). Further, amantadine (5 - 10 mg/kg, i.p.) and fluoxetine (5 mg/kg) were both administered either 30 min or 4 hr prior to sucrose solution presentation and intake of the solution was assessed after 2 hours of exposure. Results: Fluoxetine (2 - 10 mg/kg) administration significantly reduced sucrose solution intake in both free-fed and food-deprived rats. However, a brief treatment-test interval (30 min) resulted in a greater suppression of intake and food-deprived rats were more resistant to the suppressant effects of fluoxetine than were sated rats. Finally, the suppressant effect of fluoxetine were reversed by acute administration of amantadine (8 mg/kg) prior to sucrose solution presentation, a dose producing no inherent stimulation of consumption. Conclusion: Acute fluoxetine administration produces a reduction in palatable substance intake that is decreased in potency with a longer treatmet-test interval, an effect likely not related to pharmacokinetic considerations. Further, fluoxetine-induced consummatory suppression is reduced by prior food-deprivation. Evidence that the dopamine agonist amantadine reversed fluoxetine-induced consummatory suppression suggests a role for dopaminergic antagonism in the appetite suppressant effects of fluxetine.


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    Tytuł oryginału: Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy: preparation , size determination, in-vivo distribution, effects and dosimetry studies.
    Autorzy: Math‚ Domokos, Chaudhari Pradip R., Balogh Lajos, Polyak Andras, Kiraly R‚ka, Andócs Gabor, Perge Edina, Glavits Róbert, Janoki Gyozo A.
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.99-104, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia
  • chirurgia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • płeć męska

    Streszczenie angielskie: Background: Generator-produced beta-emitting radionuclides such as 188Re are gaining in importance for radiossynoviorthesis because of their availability on a regular basis. Material and methods: We prepared a 188Re-tin colloid in a eraction carried out either at 100 řC or at room tempereature (RT). The size of the colloid particles was measured wwith a laser lightscattering method, and their biodistribution, dosimetric apsects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed.Blood sapmles were collected post injection for estimation ofthe blood residence time. We aslo injected 2 intact rabbits in the same manner with 188Re perrhentage solution in order to observe its effects and distribution in teh body. All the treated rabbit knees were subjected to histopathology. Results: The colloid particle size distribution was different after preparation at teh different reaction temperatures, with a more suitable mean of 4.53 ćm in the RT preparation. The dose delivered to the synovial ssurface was between 33.51 and 4.21 Gy and that to the bone surface was betwen 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the knees 4 weeks after treatment, but not in the control group. Conclusions: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. ...

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