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Tytuł oryginału: Magnetization transfer technique improving magnetic resonance evidence of cerebral tuberous sclerosis in a 9-month-old infant.
Autorzy: Galluzzi Paolo, Cerase Alfonso, Bartalini Gabriella, Balestri Paolo, Venturi Carlo
Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.224-229, il., bibliogr. 23 poz.
Sygnatura GBL: 313,612

Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • płeć żeńska

    Streszczenie angielskie: Background: Intracranial lesions are the most important factors determining clinical outcome of patients with tuberous sclerosis complex. Magnetic resonance imaging is considered the method of choice for the identification of such intracranial lesions. However, their appearance at conventional magnetic resonance imaging changes with myelination. Actually, as myelination proceeds, signal intensities of gray and white matter start to reverse at approximately 6 months of age resulting in diminshed sensitivity of magnetic resonance imaging. Magnetization tranfer is a tissue-suppression technique improving image contrast in magnetic resonance imaging by suppression of background normal brain tissue. The usefulness of magnetization transfer for the assessment of tuberous sclerosis complex intracranial manifestations has been clearly demonstrated, although the information about its use in children of ň 2 years of age is scanty. Case report: The purpose of this report is to present a 9-month-old female with tuberous sclerosis complex, in whom unenhanced magnetization transfer T1-weighted images allowed the documentation of several tubers in both cerebral hemispheres, whilst conventional magnetic resonance imaging including fast-fluid-attenuated-inversion-recovery sequence showed only two right frontial tubers. Conclusion: Between the sixth month of life and complete white matter maturation, conventional magnetic resonance imaging may not show all intracranial lesions due to tuberous sclerosis complex: for a through depiction of intracranial manifestations, magnetization transfer should be added to conventional magnetic resonance sequences also in children ň 2 years of age.

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