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Tytuł oryginału: Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis.
Autorzy: Andreasyan Nune A., Hairapetian Hripsime L., Sargisova Yelizaveta G., Mardanyan Sona S., Badalyan Lena T., Khanoyan Armen S.
Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR708-CR712, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The problem of tuberculosis is increasing in a number of countries. Adenosine deaminase activity is considered in many clinics to be avaluable biochemical test of this pathology. Considerable research has been devoted to the activity of enzyme isoforms as significant tests for diagnosing tuberculosis. Material/Methods: The leve of adenosine deaminase and teh activity of its two isoenzymes in the pleural fluids of patients with tuberculous and non-tuberculous pleurisy were compared. Results: The adenosine deaminase level in tuberculous pleural effusions was higher than in non-tuberculous pleural effusions. The data we obtained suggest that the enzyme acitavity level could be a very reliable test in the differential diagnosis of tuberculous pleurisy in the Armenian population. The activity of isoenzymes ADA1 adn ADA2, or their ratios to the total ADA actiavity, throug valuable information, has no diagnostic advantage over total ADA activity in daignosing this pathology. Conclusions: The results clearly point up the value of using a total ADA activity assay in Armenian clinics for the differential daignosis of tuberculous pleurisy. Determinations of the activity level of the ADA1 adn ADA2 isoenzymes provide no diagnostic advantage over total ADA activity.

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