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Tytuł oryginału:
Further arguments against including trisialo-Fe2-transferrin in carbohydrate-deficient transferrin (CDT): a study on male alcoholics and hazardous drinkers.
Autorzy:
Arndt
Torsten,
Korzec
Aleksander,
Br
Marij,
Kropf
Jrgen
Źródło:
Med. Sci. Monitor 2002: 8 (6) s.CR411-CR418, il., tab., bibliogr. 34 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
psychiatria i psychologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
We attempted to determine whether including trisialo-Fe2-transferrin in carbohydrate-deficient transferrin (CDT) affects the diagnostic accuracy of CDT as a marker of chronic excessive alcohol intake. The criterion standard tests for the diagnosis of alcoholism and alcohol intake were the Composite International Diagnostic Interview (CIDI) and the Timeline-Followback (TLFB). The study groups (alcohol intake in each of the last 4 weeks before blood sampling) were comprised of 56 controls (ó 280 g/week, no alcoholism), 54 hazardous drinkers ( 280 g/week, no alcoholism), 63 alcoholics ( 280 g/week, alcoholism diagnosis). CDT analysis was performed with p.c.CDTri-TIA, which includes about 50 p.c. of trisialo-Fe2-transferrin in CDT, and ChronAl-col. D, which excludes this transferrin isoform from CDT. Depending on the cut-offs for the CTD/transferrin ratio (upper or lower limit of the test-specific borderlines) and on the patient group, the diagnostic sensitivity was 18.1 p.c. - 72 p.c. for p.c.CDTr-TIA, as opposed to 50.p.c. - 82.5 p.c. for ChronAlcol.D. The diagnostic accuracy was 62.8 p.c. - 78.5 p.c. for p.c.CDTri-TIA and 71.8 p.c. - 86.6 p.c. for ChronAlcol.D. The latter test consistently showed higher diagnostic sensitivity and accuracy than p.c. CDTri-TIA. The diagnostic specificity was 85.7 p.c. - 98.2 for p.c.CDTri-TIA and 91.1 p.c. - 92.2 p.c. for ChronAlcol.D. The areas under the ROC curve were 0.810 p.c. - 0.885 for p.c.CDTri-TIA and 0.867 p.c. - 0.896 for ChronAlcol.D. The present study and data from the literature indicate that including parts of trisialo-Fe2-transferrin by the p.c. CDRri-TIA test significantly reduces the diagnostic sensitivity and thus accuray of CDT as a marker of chronic excessive alcohol use.
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