Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: BYKOKUROGLU
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Tytuł oryginału: In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase.
Autorzy: Altikat Sayit, Ciftci Mehmet, Bykokuroglu Mehmet E.
Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.67-71, il., tab., bibliogr. 14 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The study investigated in vitro effects of halothane, isoflurane, ketamine, sevoflurane, prilocaine, diazepam, and midazolam on enzymatic activity of human red blood cell glucose-6-phosphate dehydrogenase (G6PD; E.C. 1.1.1.49). G6PD was purified from human red blood cells by 2',5'-ADP-sepharose 4B affinity gel. Enzymatic activity was spectrophotometrically measured at 340 nm according to the method of Beutler. I50 values were determined from drug activity 9p.c.) - drugconcentration curves. I50 values were as follows: 0.72 mM for isoflurane, 1.82 mM for sevoflurane, 0.38 mM for diazepam, and 0.0019 mM for midazolam. But halothane, ketamine and prilocaine had no inhibitory effect on the G6PD activity in in vitro.

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    Tytuł oryginału: Some drug effects on the activity of erythrocyte hexokinase and glucose 6-phosphate dehydrogenase enzymes in vitro and in vivo.
    Autorzy: Ciftci Mehmet, Senyayla Faruk, ™zdemir Hasan, Bykokuroglu Mehmet E.
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.673-679, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Effects of theophyline, lidocaine, cyclophosphamide, hyoscine N-butyl bromide, tranexamid acid and cytarabine on hexokinase (HK) from human erythrocytes have been investigated in vitro. In addition, in vivo effects of theophylline and lidocaine were investigated in rats. HK was purified from human red blood cells by DEAE-Sephadex A50 ion exchange chromatography. HK activity was measured spectrophotometrically at 25řC in a system coupled with glucose 6-phosphate dehydrogenase, according to Beutler's method at 340 nm. Cyclophosphamide, hyoscine N-butyl bromide, tranexamic acid and cytarabine had no effects on human erythrocyte HK activity in in vitro conditions. On the other hand, human erythrocyte HK was inhibited by theophyline, but activated by lidocaine. IC 50 value for theophylline was 0.013 M. In the case of in vivo studies, 6 mg kg-1 of theophylline inhibited the rat HK activity by 43 p.c. at the first 1.5 h (p 0.001). A dose of 5 mg kg-1 of lidocaine activated the rat HK activity by 41 p.c. (p 0.001), 22 p.c. (p 0.001), and 11 p.c. (p 0.05), at 1.5, 3 and 6 h respectively.

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