Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: AVRAMOVIĆ
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku

1/1

Tytuł oryginału: Alteration of 99mTc-DMSA biodistribution in glomerulonephritis.
Autorzy: Rajić Milena, Bogićević Momćilo, Antić Slobodan, Mitić Branka, Avramović Marina, Ilić Slobodan, Vlajković Marina, Mitić-Zlatković Marina, Stefanović Vladisav
Źródło: Nucl. Med. Rev. 2002: 5 (1) s.15-19, il., tab., bibliogr. 26 poz.
Sygnatura GBL: 313,603

Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of this study was to assess the relation between 99mTc-DMSA biodistribution and its reliability as a marker of renal function in patients with glomerular kidney diseases. Material and methods: Sixty-seven patients involved in this study were classified into two group saccording to 99mTc-DTPA clearance and serum creatinine values: the 1st group consisted of 42 patients without renal failure while the 2nd group included 25 patients with renal failure. 99mTc-DMSA biodistribution was determined by measuring kidney, blood and urine activity at 2 h and 4 h. Results: The results, compared with those of 23 healhty volunteers, indicated the quantitative alteration of 99mTc-DMSA distribution in both glomerulonephritis patient groups. In reference to the control mean values of 2 h and 4 h, in patients without renal failure, kidney activity was found decreased to 52 p.c. and 57 p.c., while the blood activity increase of 37 p.c. and 44 p.c. was recorded together with the urine activity increase of 38 p.c. and 23 p.c. In patients with renal failure the alterations of renal and blood activity were more remarkable, but the urine loss was found to be unchanged. Conclusions: It is suggested that these biodistribution changes originate mainly from tubular impairment. However, in glomerulonephritis patients, altered glomerula filtration might considerably affect biodistribution of this radiopharmaceutical and limits its suitability for precise quantitative estimation of renal function.

    stosując format: