Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
ASSERT
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Tytuł oryginału:
mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication.
Autorzy:
Schiemann
Uwe,
Konturek
Jan W.,
Assert
Roland,
Rembiasz
Kazimierz,
Konturek
Stanisław J.,
Pfeiffer
Andreas
Źródło:
Med. Sci. Monitor 2002: 8 (2) s.CR53-CR58, il., tab., bibliogr. 34 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
genetyka
mikrobiologia
gastroenterologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
Background: Epidermal growth factor (EGF) receptor ligands (EGFRL) including transforming growth factor alpha (TGF-ŕ), amphiregulin, and heparin binding -EGF (HB-EGF) are involved in gastric mucosal repair in chronic gastritis. Their mRNA expression has been shown to be upregulated after Helicobacter pylori (H. p.)-eradication but little is known about this gene expression in atrophic gastritis. The purpose of our study was to investigate EGFRL mRNA expression in gastric mucosa of patients with atrophic gastritis before and after H. p.-eradication. Material/Methods: Antral mucosal biopsies were obtained during endoscopy in 10 H. p. positive patients with atrophic gastritis and in 10 H. p. negative controls with intact mucosa. Total RNA of antral biopsies was extracted and RT-PCR was performed, the PCR-products being measured densitometrically. Values were compared with mRNA expressions in H. p. negative antral mucosa (n = 10). Results: Gastric biopsies revealed mRNA expression for TGF-ŕ, amphiregulin and HB-EGF, both in H. p. positive atrophic antritis and in H. p. negative healthy mucosa. The mRNA expression of TGF-ŕ in atrophic gastritis was significantly upregulated after H. p.-eradication, whereas that of amphiregulin did not change after this eradication. Expression of HB-EGF mRNA was higher in H.p.-infection than after H.p.-eradication or in H.p. negative healthy subjects. Conclusions: H.p. positive atrophic gastritis is associated with differential mRNA expression of EGF receptor ligands. H.p.-eradication in this entity leads to unequal changes of these growth factor expressions compared to chronic active gastritis without atrophy.
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