Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.
Med. Sci. Monitor 2002: 8 (7) s.MT118-MT123, il., tab., bibliogr. 18 poz.
Hasła klasyfikacyjne GBL:
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
Background: Recently, the ZEUSTM Robotic Surgical System has been introduced to increase the precision of endoscopic cardiac surgery. This study investigated its clinical use for endoscopic coronary artery bypass grafting. Material/Methods: Between 1998 and 2001, 41 patients with single and multivessel disease were operated on using the ZEUSTM system. The robotic system was introduced step by step into clinical practice. Initially, the system was used only for endoscopic internal mammary artery (IMA) harvest (n = 12), later for coronary anastomoses on the arrested (n - 13) or beating heart after median sternotomy (n = 6), and finally for endoscopic coronary bypass grafting on either the arrested (n = 2) or beating heart (n - 8). Results: Endoscopic IMA harvest ranged from 48 to 110 min and was completed in all cases. In the sternotomy group, the robotic anastomosis time averaged 21 min on the arrested and 25 min on the beating heart, respectively (n.s.). In the endoscopic cases, the average time for endoscopic anastomosis was 41 min on the arrested and 36.5 min on the betaing heart (n.s.), with an overall duration of surgery between 4.0 and 8.0 hours. One endoscopic case was intraoperatively converted to a MIDCAB procedure with manual anastomosis. THe total patency rate of all graft anasomoses, confirmed by early postoperative angiographic control, was 97 p.c. One patient underwent reopartion with an uneventful postoperative course. Conclusions: The present study demonstrates the feasibility of endoscopic coronary revascularization using a computer-assisted surgical robotic system on the arrested and beating heart in selected patients.
Application of high resolution 31P NMR spectroscopy to the characterization of the phospholipid composition of tissues and body fluids - a methodological review.
Med. Sci. Monitor 2002: 8 (11) s.MT205-MT222, il., tab., bibliogr. 91 poz.
Hasła klasyfikacyjne GBL:
Background: The detailed analysis of lipids, especially phospholipids, has become progressively important, since these molecules represent intercellular messenger molecules and are involved in a number of diseases. Therefore, the analysis of the lipid pattern of blood, for example, may also be useful as a diagnostic tool. Unfortunately, suitable methods of p hospholipid analysis are often time-consuming and tedious, since most of them include a variety of separation and derivatization steps. methods allowing lipid analysis in a single step would be highly useful. The aim of this review is to show that high resolution 31P NMR spectroscopy is a convenient and precise analytical tool for the phospholipid analysis of extracts from biological samples (tissues and body fluids). The first part of this review discusses the physiological relevance of individual kinds of phospholipids and related, established analytical techniques for their investigation. THe second part contains an overview on the requireemnts for 31P NMR to improve spectral resolution and sensitivity, its cpabilities and its limitations. In the third part, we discuss the application of 31P NMR to the most important phospholipid classes, as well as different tissue and body fluid extracts. The article concludes with a brief look at future developments and potential applicaitons of the technique.
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