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Tytuł oryginału: Lipid-based antifungal agents: a concise overiew.
Autorzy: Arikan Sevtap
Źródło: Cell. Mol. Biol. Lett. 2002: 7 (3) s.919-922, bibliogr. 5 poz.
Sygnatura GBL: 306,513

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The development of lipid formulations of antifunagal drugs has been a remarkable progress in the systemic antifungal arena. The lipid-based amphotericin B formulations; amphotericin B lipid complex (ABLC), amphotericin B colloidal dispersion (ABCD), and liposomal amphotericin B (L-AMB) have been in clinical use since 1990s. They are significantly less nephrotoxic than the parent compound and can be safety used at higher doses. The primary cost of these formulations is significantly high and the extent of data related to their head-to-head comparison remains limited. The lipid formulation of nystatin, liposomal nystatin, is another lipid-based polyene under development. Available data concerning the in vitro activity, pharmacokinetic profile, in vivo efficacy, and safety of these formulations are summarized in this overview.

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