Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ARAKI
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17.
Autorzy: Kowalska Anna, Hasegawa Masato, Miyamoto Katsuichi, Akiguchi Ichiro, Ikemoto Akito, Takahashi Keikichi, Araki Wataru, Tabira Takeshi
Źródło: J. Appl. Genet. 2002: 43 (4) s.535-543, il., tab., bibliogr. s. 542-543
Sygnatura GBL: 305,055

Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • genetyka
  • neurologia

    Typ dokumentu:
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Mutations in the microtubule-associated tau gene are responsible for frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). A reduced ability of the mutated microtubule-associated tau protein to interact with microtubules causes microtubule destabilization leading to deleterious effects on axonal transport and the formation of tau filaments. Here, we describe a new mutation of the tau gene, a T - C transition at position +11 of the intron following exon 10 (T - C3'E10 + 11) in the family showing frontotemporal dementia with very early age of onset (the first decade of proband's life). The T - C 3'E10 + 11 mutation caused a large increase in the proportion of transcripts containing exon 10 detected by exon-trapping analysis. Our study confirmed that the T - C 3'E10 + 11 mutation as the other 5' splice site mutations of tau exon 10, modifies alternative splicing of exon 10.


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    Tytuł oryginału: How is "coverage" defined for occupational health services?
    Autorzy: Muto Takashi, Mizoue Tetsuya, Araki Yoko, Miyazaki Shogo, Marui Eiji
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.147-154, tab., bibliogr. 31 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The proportion of workers receiving occupational health services (OHS), or OHS coverage, is considered an important indicator in the evaluation of the national OHS levels. Although the term "coverage" is used in some papers, the definition of the term appears to vary from author to author. Despite vague definitions of the term, the issue has not been much studied. It appears that this vagueness has not led to attempts to establish a clear definition of the term. This study was undertaken to clarify the meaning of "coverage" when used in relation to OHS. Papers using "coverage" as an indicator of the OHS levels or discussing the issue were collected and analyzed. The first aspect examined concerned the definition of "coverage." Next, the denominator (the target population), and methods for estimating the numerator (the number of workers provided with OHS) were described according to this definition. Few papers dealing with OHS coverage provided an explicit definition; none of the papers stated clearly the OHS functions encompassed when considering coverage, using simply the term in the context. Nor was the worker category to be represented in the denominator discussed, e.g. employees only, or the entire working population. The method for estimating the numerator was generally undefined. This study makes it clear that the term "coverage" in relation to OHS is currently used without clear definition. To permit objective assessments of the national OHS levels, "coverage" must be defined in terms of three elements: OHS functions, the numerator and the denominator of the proportion representing the extent of OHS coverage.

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