Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ANDERSON
Liczba odnalezionych rekordów: 2



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku

1/2

Tytuł oryginału: Biomarkers in human disease states.
Autorzy: Anderson Diana
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.69-81, tab., bibliogr. 23 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • onkologia
  • endokrynologia
  • hematologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Oncogenes are involved with the regulation of cellular proliferation and thus could be important in the development of disease states. The ras genes encode a protein of 189 amino acids of molecular weight 21kDa, designated as p21, and are in all eukaryotic cells contained on the inner surface of the plasma membrane. Ras p21 proteins were measured in plasma from lung cancer patients and patients with chronic obstructive pulmonary disease (COPD). Proteins were separated by gel electrophoresis, transferred to a nitrocellulose membrane by Western blotting and detected by chemiluminescence. A monoclonal pan-ras antibody was used as the primary antibody. Optical densities of the peak area of the protein bands were calculated and values which were two standard deviations above negative control means were considered positive. Many of the cancer patients and some of the COPD patients gave positive responses. Thus an increase in ras oncoproteins could be a biomarker for cancer or the disease state in general, but it cannot be ruled out that it is a biomarker for exposure since many of the individuals examined were smokers. The single cell gel electrophoresis (Comet) assay was used in lymphocytes from patients with diabetes and thalassemia. Brieflyy this assay conducted under alkaline conditions detects single strand breaks and alkali-labile sites by measuring the migration of denatured fragments within an agarose gel subjected to electrophoresis. When diabetes insulin-dependent and non-insulin-dependent ...


    2/2

    Tytuł oryginału: Urine microalbumin excretion in relation to exercise-induced electrocardiographic myocardial ischaemia.
    Autorzy: Waldron Julian S., Baoku Yetunde, Hartland Andrew J., Anderson Neil R., Horton Richard C., Gama Rousseau
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR725-CR727, tab., bibliogr. 7 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Microalbuminuria, a marker of endothelial cell dysfunction, is associated with atherosclerosis and is a predictor of coronary heart disease. It has been suggested that patients with coronary heart disease have exaggerated exercise-induced urinary microalbumin excretion but this is controversial. We, therefore, measured urine microalbumin excretion in men before and after an exercise electrocardiogram. Material/Methods: Urine microalbumin excretion expressed as the albumin-creatinine ratio (ACR) was measured before and after an exercise electrocardiogram in 10 subjects with exercise-induced myocardial ischaemia and 14 subjects without exercise-induced myocardial ischaemia. Results: In subjects with a positive exercise electrocardiogram, the pre-exercise electrocardiogram ACR 3.3 ń 5.50; (mean ń SD) significantly increased (p = 0.0371) follwoing exercise (6.30 ń 10.25). In subjects with a negative exercise electrocardiogram, the pre-exercise electrocardiogram ACR (0.73 ń 0.52) also significantly increased (p = 0.0295) following exercise (2.04 ń 1.81). Pre-exercise ACR was higher (p = 0.0164) in subjects with a positive exercise electrocardiogram (3.3 ń 5.50) than in those subjects with a negative exercise electrocardiogram (0.73 ń 0.52). Incremental and post-exercise ACR were not significantly different in those with normal and abnormal exercise electrocardiograms. Conclusion: Patients with exercise-induced myocardial ischaemia have pre-exercise urine microalbumin excretion. Exaggerated uring microalbumin excretion in resposne to exercise is not associated with exercise-induced myocardial ischaemia.

    stosując format: