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Tytuł oryginału: The application of the Mancini technique as a diagnostic test in the CSF of tuberculous meningitis patients.
Autorzy: Kashyap Rajpal S., Agarwal Neha P., Chandak Nitin H., Taori Girdhar M., Biswas Saibal K., Purohit Hemant J., Daginawala Hatim F.
Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT95-MT98, il., tab., bibliogr. 16 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • neurologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Tuberculous meningitis (TBM) is still a serious cause of morbidity and mortality in developing nations, and the timing of treatment is the most crucial factor affecting the ultimate outcome. To establish a rapid diagnosis, we used Single Radial Immuno-Diffusion (SRID) to detect circulating mycobacterium antigen in the CSF of patients with clinically suspected TBM. Single radial immunodiffusion is the simplest of all immunotechniques for the quantitative determination of antigen or antibody. CSF was collected by standard lumbar puncture. Antiserum was raised against CSF from clinically suspected TBM patients by standard Immunization procedures. The developed protocol was tested with 73 CSF samples collected over a period of one year. The assay gave 94 p.c. sensitivity for the detection of mycobacterium antigen in the CSF of patients with clinically suspected TBM. This study suggests that single radial immunodiffusion is useful for quantitative as well as qualitative determination of mycobacterium antigen. The developed technique is of potential value in the laboratory diagnosis of TBM.

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