Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ABRAHAM
Liczba odnalezionych rekordów: 4



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Tytuł oryginału: Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.
Autorzy: Wieczerzak Ewa, Drabik Piotr, Łankiewicz Leszek, Ołdziej Stanisław, Grzonka Zbigniew, Abrahamson Magnus, Grubb Anders, Br”mme Dieter
Źródło: J. Med. Chem. 2002: 45 (19) s.4202-4211, il., tab., bibliogr. 69 poz.
Sygnatura GBL: 312,133

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A series of azapeptides as potential inhibitors of cysteine protease were synthesized. Their structures, based on the binding center of cystatins, contain an azaglycine residue (Agly) in place of the evolutionary conserved glycine residue in the N-terminal part of the enzyme binding region of cystatins. Incorporation of Agly should lead to deactivation of the acyl-enzyme complex formed against nucleophilic attack by water molecules in the final step of peptide bond hydrolysis. The majority of synthesized azapeptides shows high inhibitory potency toward the investigated cysteine proteases, papain, cathepsin B, and cathepsin K. One of them, Z-Arg-Leu-Val-Agly-Ile-Val-OMe (compound 17), which contains in its sequence the amino acid residues from the N-terminal binding segment as well as the hydrophobic residues from the first binding loop of human cystain C, proved to be a highly potent an selective inhibitor of cathepsin B. It inhibits cathepsin B with a Ki value of 0.088 nM. To investigate the influence of the structure of compound 17 for its inhibitory properties, we determined its conformation by means of NMR studies and theoretical calculations. The Z-Arg-Leu-Val-Agly fragment covalenty linked to Cys29 of cathepsin B, was also developed and modeled, in the catalytic pocket of the enzyme, through a molecular dynamics approach, to analyze ligand - protein interactions in detail. Analysis of the simulation trajectories generated using the AMBER force field provided us with atomic-level understanding of the conformational variability of this inhibitor, which is discussed in the context of other experimental and theoretical data.

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    Tytuł oryginału: Religious sensitivity pitted against the need to know: autopsy of Jewish children in Israel.
    Autorzy: Abraham Ron Ben, Weinbroum Avi A., Kassem Riad, Barzilay Zohar, Paret Gideon
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.SR1-SR4, bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to compare autopsy findings with antemortem findings in children who died in a pediatric intensive care unit. Material/Methods: Consecutive series of patietns who died in the pediatric intensive care unit during 2-year period were used. The study was conducted as a retrospective chart review at community, regional-referral, university-affiliated tertiary medical center of 1200 bed in Israel. Results: Permission was given to perform autopsies on only 10 children (23.8 p.c., mean age 85.7 months) out of the 42 who died during the study period. The mean length of stay in the pediatric intensive care unit prior to death was 13.3 days. Cardiac or hemato-oncologic diseases comprised the major pre-admission diagnoses. The autopsy revealed a major finding that, if known before death, would have altered clinical management in 50 p.c. of the patients: pneumonia, pneumonitis as well as intestinal perforation or necrosis. No correlation was found between patient length of stay in the intensive care unit and the autopsy disclosed information. Conclusions: Our findings suppert the importance of autopsy assessment in the pediatric intensive care setup. We beliewve that postmortem examination is also essential for improving the quality of pediatric patient care.

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    Tytuł oryginału: Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism.
    Autorzy: Dhossche Dirk, Applegate Heather, Abraham Ann, Maertens Paul, Bland Lorna, Bencsath Aladar, Martinez Jos‚
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.PR1-PR6, il., bibliogr. 59 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Autistic Disorder is an early-onset developmental disorder with severe lifelong impact on social functioning, communication, and behavior. There is currently no marker or cure. The pathophysiology and etiology are obscure. Evidence for abnormal gamma-aminobutyric acid (GABA) function in Autistic Disorders is limited. A few case-reports and small studies have reported differences in GABA levels in plasma, platelets, and urine, compared to controls. Further studies on abnormalities of GABA function in Autistic Disorder are warranted. Material/methods: Plasma GABA levels were measured using a new and sensitive technique, based on gas chromatography/mass spectrometry, in a small group of youngsters with Autistic Disorder and Attention-Deficit/Hyperactivity Disorder. Participants were outpatients between ages 5-15, satisfying modern criteria for these disorders. Results: Elevated plasma GABA levels were found in youngsters with Autistic Disorder. Psychotropic medications did not seem to affect plasma GABA levels in this study. Plasma GABA levels decreased with age. Conclusions: Elevated plasma GABA levels may be a biochemical marker of Autistic Disorder. This study supports the hypothesis that GABAergic mechansms play a role in the etiology or pathophysiology of Autistic Disorder. However, the hypothesis remains unspecified owing to lack of research. Future studies on the clinical associations of seizure disorders, mood disorders, and catatonia in autistic people may provide the necessary data to formulate a coherent theory of GABA dysfunction in Autistic Disorder. More trials of medication with known or suspected effects on GABA function are qarranted.

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    Tytuł oryginału: Long-term assessment of pulmonary function tests in pediatric survivors of acute respiratory distress syndrome.
    Autorzy: Abraham Ron Ben, Weinbroum Avi A., Roizin Hector, Efrati Ori, Augarten Arie, Harel Ran, Moreh Osnat, Barzilay Zohar, Paret Gideon
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR153-CR157, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: Background: The aim of the study was to evaluate long-term pulmonary function tests in pediatric survivors of acute respiratory distress syndrome (ARDS). Material/Methods: Observational study based on a telephone poll of retrospectively identified post ARDS children who were hospitalized in a pediatric intensive care unit (PICU) in a general 1200-bed teaching, tertiary, regional referral center for children. Results: Follow-up pulmonary function tests were achieved in only 7 children, with a man age of 7.3 ń 4.3 years (range 3-12) and following 5.6 ń 4.3 years after PICU discharge. The etiology for ARDS included: lymphoma (n = 2), pneumonia (n = 2), aspiration (n = 1), petrol ingestion (n - 1) and snake envenomation (n = 1) and snake envenomation (n = 1). The children had been ventilated for 9.4 ń 7.3 days and their worst PaO2/FiO2 ratio was 65.1 ń 17.0 mm Hg. The follow-up pulmonary functions in all the children was within normal limits except for one child who had mildly reduced DLco and one who had mild exercise-induced hypoxemia (oxyhemoglobin saturation of 94 p.c.). neither of the two nor the others showed subjective symptoms or clinical physical limitations. Conclusions: Children who survive ARDS apparently enjoy long-term normal pulmonary function. Some, however, amy present sublicnial dysfunction that persists for many years after the acute episode and evoked only by sophisticated lung tests.

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