Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ŻYLICZ
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Tytuł oryginału: Mutacje genów p53 i p16 w niedrobnokomórkowym raku płuca.
Tytuł angielski: p53 and p16 gene mutations in non-small cell lung cancer.
Autorzy: Jassem Ewa, Ramlau Rodryg, Dziadziuszko Rafał, Szymanowska Amelia, Jakóbkiewicz Joanna, Lamperska Katarzyna, Kobierska Grażyna, Skokowski Jan, Dyszkiewicz Wojciech, Mackiewicz Andrzej, Żylicz Maciej, Jassem Jacek
Źródło: Pneumonol. Alergol. Pol. 2002: 70 (1/2) s.64-70, il., tab., bibliogr. 20 poz., sum.
Sygnatura GBL: 301,096

Hasła klasyfikacyjne GBL:
  • genetyka
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of this study was to assess prospectively the occurrence of p53 and p16 mutations (considered separately and together) in NSCLC in terms of their clinical and prognostic relevance. Study group included 87 patients who underwent pulmonary resectiom for cure. p53 and p16 mutations were found in 22 (25 p.c.) and 14 (16 p.c.) cases, respectively. In eight patients (9 p.c.) both mutations were present, and the tendency for their common occurrence was significant (p = 0.02). There was no relation between mutation and clinical characteristics. Median survival in the entire group was 17 months and thr 3-year survival probability - 41 p.c. There was no correlation between the occurrence of many mutation (considere separately or together) and survival. Theses results indicate that p53 and p16 gene mutations tend to occur together in NSCLC, however these alterations seem not to have noteworthy clinical and prognostic significance.

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