Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ŁYSZKIEWICZ
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku
1/1

Tytuł oryginału: Udział receptorów interleukiny 2 i interleukiny 12 w przekazywaniu sygnału podczas aktywacji komórek układu odpornościowego.
Tytuł angielski: Contribution of interleukin-2 and interleukin-12 receptors in signal transduction.
Autorzy: Łyszkiewicz Marcin, Pajtasz-Piasecka Elżbieta
Źródło: Post. Hig. 2002: 56 (6) s.707-731, il., tab., bibliogr. s. 729-731, sum.
Sygnatura GBL: 301,727

Hasła klasyfikacyjne GBL:
  • immunologia

    Streszczenie angielskie: Interleukin-2 (IL-2) and interleukin-12 )IL-12) belong to lympho-hematopoietic cytokines and play a critical role in the promotion and enhancement of cellular response. IL-2 as the second signal of antigenic stimulation facilitates the transition of the cell cycle from phase G1 to phase S and is responsible for the regulation of T lymphocytes proliferation and the activation of cytotoxic T cells, natural killers, macrophages and granulocytes. IL-2 is the dominant factor in T helper cells polarization leading to the secretion of IFN-ç. Receptors for both of the cytokines (IL-2R or IL-12 R) represent class I cytokine receptors composed of multiple subunits. Generally, they contain a similar extracellular conserved motif of four cysteines, and amino acid sequence - WSXWS (interacting directly with ligand) but possess no catalytic domens in the intrinsic tail of the chains. For this reason, to transfer the impact, the association with number of signaling molecules, allowing the activation of the signling pathways is required. The connections of IL-2R or IL-12R with their ligands recuit receptor-associated cytoplasmic proteins from the JAK family (JAK1/JAK3 or JAK2/TYK2, respectively), which catalyze the phosphorylation of themselves and intrinsic tyrosine residues on the receptor, creatuing STAT docking sites. This phosphorylated and subsequent dimerised proteins bind rapidly to DNA and activate it. This review, presents the differences and similarities between the signaling pathways triggered by IL-2R or IL-12R ligation.

    stosując format: