Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ŁUSZCZYK
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor ŕ treatment.
Autorzy: Ziółkowska Maria, Kurowska Mariola, Radzikowska Anna, Łuszczykiewicz Grażyna, Wiland Piotr, Dziewczopolski Wojciech, Filipowicz-Sosnowska Anna, Pazdur Jacek, Szechiński Jacek, Kowalczewski Jacek, Rell-Bakalarska Maria, Maśliński Włodzimierz
Źródło: Arthritis Rheum. 2002: 46 (7) s.1744-1753, il., tab., bibliogr. 32 poz.
Sygnatura GBL: 305,037

Hasła klasyfikacyjne GBL:
  • farmacja
  • reumatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Objective. To test the hypotheses that 1) proinflammatory cytokines affect osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappaB ligand (sRANKL) production and therefore the OPG and sRANKL levels differ in rheumatoid arthritis (RA) patients in comparison with healthy individuals; and 2) anti-tumor necrosis factor ŕ (anti-TNFŕ) therapy influences OPG and sRNAKL levels. Methods. Sera were obtained from healthy individuals or RA patients receiving the combination of infliximab and methotrexate. Peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) were isolated from RA patients. Fibroblast-like synoviocytes (FLS) were isolated from synovial tissue obtained at total knee replacement in RA patients. Supernatants from cells stimulated with cytokines were collected after culture in vitro. Concentrations of OPG and sRANKL were determined by enzymelinked immunosorbent assays. Results. A strong positive correlation between OPG concentration and age was observed in healthy individuals but not in RA patients. The OPG and sRANKL levels were higher in RA patients than in healthy controls. Cultured FLS spontaneously secreted much higher amounts of OPG than PBMCs or SFMCs. Proinflammatory cytokines enhanced OPG production. Anti-TNFŕ treatment resulted in the normalization of serum OPG and sRANKL levels in RA patients without influencing the OPG:sRANKL ratio. Conclusion. Although higher serum levels of OPG and sRANKL are present in RA patients than in healthy individuals, the ratio of OPG:sRANKL is similar. There is an age-dependent increase of OPG but not sRANKL levels in healthy subjects. Anti-TNFŕ treatment results in the normalization of elevated levels of OPG and sRANKL in RA patients.

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    Tytuł oryginału: Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats.
    Autorzy: Góźdź A., Szczepańska-Sadowska E., Szczepańska K., Maśliński W., Łuszczyk B.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.349-357, il., bibliogr. 29 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Vasopressin plays significant role in regulation of blood pressure by means of V1 and V2 receptors, however regulation of synthesis of these receptors in hypertension is only poorly recognized. The purpose of the present study was to compare expression of V1a, V1b and V2 vasopressin (R) mRNA in the renal cortex, renal medulla and the heart of hypertensive renin transgenic TGR(mRen2) 27 rats (TGR) and of their parent normotensive Sprague Dawley (SD) strain. The study was performed on 12 weeks old tGR and SD rats. Competitive PCR method was used for quantitative analysis of V1a, V1b and V2 receptors mRNA in fragments of renal cortex, renal medulla and apex of the left ventricle of the heart. In both strains expression of V1aR and V2R mRNA was significantly greater in the renal medulla than in the renal cortex. In the renal medulla but not in the cortex expression of V1aRmRNA was significantly greater in TGR than in SD rats. V2R mRNA expression was similar in the renal cortex and renal medulla of both strains. V1aR mRNA was well expressed in the heart of SD and TGR rats, however there was no significant difference between these two strains. V2R mRNA was not present in the heart. V1bR mRNa could not be detected either in the kidney or in the heart. The results provide evidence for specific increase of expression of V1a receptors mRNA in the renal medulla of TGR rats.

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