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Tytuł oryginału: Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy.
Autorzy: Dłużniewska Joanna, Zolich Dorota, Polański Jerzy, Zając Leszek, Sitkiewicz Dariusz, Łukomska Barbara
Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR690-CR696, il., tab., bibliogr. 35 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The purpose of our study was to investigate hepatocyte proliferation and the expression of hepatocyte growth factor (HGF) in liver tissue and blood from patients with benign and malignant liver tumors after partial hepatectomy. Material/Methods: We studied 25 consecutive patients undergoing partial hepatectomy for metastatic colorectal adenocarcinoma (15 cases) adn benign liver tumors (10 cases). Immunohistochemical examination for teh rpesence of PCNA adn HGF, c-Met/HGF-receptor expression was performed on formalin-fixed samples from: a) sections of resected fragments of liver tissue remote from the tumor; b) tumor tissue; c) remnant liver, 30 min after hepatectomy; d) fine needle aspiration liver biopsy, 7 days after liver resection. Circulating HGF and the level fo AFP adn GGT as biomarkers for liver cell regeneration were measured in the patients' blood at the same time. Results: The proliferation rate of liver cells was higher in patients with malignant than benign liver tumors. This correlated with incrased HGF in blood, but not with the expression of HGF and c-MET/HGF-R in liver tissue. The expression of HGF was detected in specimens from colorectal liver metastases. Conclusion: The mutual interactions between tumor and other cells may influence the proliferation of hepatocytes throughout the regenerative process in patients with colorectal carcinoma metastases after partial hepatectomy.

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