Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
CHOMIKI
Liczba odnalezionych rekordów:
10
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1/10
Tytuł oryginału:
Vessels involved in the venous outflow from glandular mucosa of hamster stomach.
Autorzy:
Moskalewski
Stanisław,
Biernacka-Wawrzonek
Dorota,
Klimkiewicz
Justyna,
Zdun
Rafał
Źródło:
Folia Morphol. 2002: 61 (2) s.81-87, il., bibliogr. 18 poz.
Sygnatura GBL:
301,720
Hasła klasyfikacyjne GBL:
gastroenterologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Streszczenie angielskie:
Blood from the glandular part of hamster gastric mucosa is drained by collecting venules, running from the subepithelial layer towards lamina muscularis mucosae. To visualise vessels involved in the venous outflow, hamsters were exposed to atropine and subjected to intravital ligation of portal vein, causing strong hyperaemia. Distribution of vessels and their connections were studied a) in translucent, flat preparations of the glandular stomach, b) in thic sections of glandular mucosa cleared in the mineral oil, and c) in semi-thin plastic or parafin sections. Collecting venules were drained by single vessels running parallel to the lamina muscularis mucosae (paramuscular venules), which, in turn, joined submucosal veins through opening in muscularis mucosae. Moreover, some collecting and paramuscular venules discharged into venules belonging to vascular triples composed of two venules and arteriole. The triplets were also parallel to muscularis mucosae. Triplets did not form connections with submucosal veins but passed on the abluminal surface of muscularis mucosae. Thus, some structural elements involved in venous outflow from glandular gastric mucosa differ from those in rats, in which vascular triplets were absent and all collecting venules drained into single paramuscular vessels. Conctraction/relaxation of muscularis mucosae may regulat the amount of blood present in the venous system of the mucosa and the diameter of venules. Rhythmical changes of the latter could cause changes in intramucosal pressure, affecting movement of tissue fluid in the mucosa and thus the functio of gastric cells.
2/10
Tytuł oryginału:
Selectivity of oxidative stress targeting in estorgen-induced experimental nephrocarcinogenesis.
Autorzy:
Kobiela
Jarek,
Krajewski
Jacek,
Kalińska-Błach
Beata,
Stefaniak
Tomasz
Źródło:
Acta Bioch. Pol. 2002: 49 (1) s.51-58, il., tab., bibliogr. 38 poz.
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
endokrynologia
farmacja
nefrologia
onkologia
Typ dokumentu:
praca związana ze zjazdem
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Streszczenie angielskie:
Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster neprhocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not afect lipids. Subcellular localization of the oxidative stress target wass determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected bay the oxidative stress.
3/10
Tytuł oryginału:
Adhesive properties of cacinoembryonic antigen glycoforms expressed in glycosylation-deficient Chinese hamster ovary cell lines.
Autorzy:
Krop-Watorek
Anna,
Kłopocki
Arkadiusz G.,
Czerwiński
Marcin,
Lisowska
Elwira
Źródło:
Acta Bioch. Pol. 2002: 49 (1) s.273-283, il., bibliogr. s. 280-283
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
immunologia
ginekologia i położnictwo
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
płeć żeńska
in vitro
Streszczenie angielskie:
Carcinoembryonic antigen (CEA) is an oncofoetal cell surface glycoprotein that serves as an important tumour marker for colorectal and some other carcinomas. Its immunoglobulin-like structure places CEA within the immunoglobulin superfamily. CEA functions in several biological roles including homotypic and heterotypic (with other CEA familiy members) cell adhesion. Cell-cell interaction can be modulated by different factors, e.g., post-transplational modifications such as glycosylation. The purpose of this study was to examine whether changes in carbohydrate composition of CEA oligosaccharides can influence homotypic (CEA-CEA) interactions. In order to modulate glycosylation of CEA we used two different glycosylation mutants of Chinese hamster ovary (CH)) cells, Lec2 and Lec8. Lec2 cells showuld produce CEA with nonsialylated N-glycans, while Lec8 cells should yield more truncated sugar structures than Lec2. Parental CHO (Pro5) cells and the glycosylation deficient mutants were stably transfected wtih CEA cDNA. All three CEA glycoforms, tested in a solid-phase cell adhesion assay, showed an ability to mediate CEA-dependent cell adhesion, and no qualitative differences in the adhesion between the glycoforms were observed. Thus, it may be assumed that carbohydrates do not plas a role in homotypic adhesion, and the interactions between CEA molecules depend solely on the polypeptide structure.
4/10
Tytuł oryginału:
Udział mitochondriów w poniedokrwiennej śmierci neuronów w hipokampie - protekcyjna rola cyklosporyny A.
Tytuł angielski:
Involvement of mitochondria in the delayed neuronal cells death after transient ischemia: neuroprotection by cyclosporin A.
Autorzy:
Zabłocka
Barbara,
Domańska-Janik
Krystyna
Źródło:
Dział. Nauk. PAN 2002 (13) s.113-114, il., sum.
Sygnatura GBL:
801,551
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
Wskaźnik treści:
zwierzęta
chomiki
5/10
Tytuł oryginału:
Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 1: Alterations of myelinated axons.
Autorzy:
Liberski
Paweł P.,
Bratosiewicz-Wąsik
Jolanta,
Gajdusek
D. Carleton,
Brown
Paul
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.121-129, il., bibliogr. s. 127-129
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Streszczenie angielskie:
Classical and ultrastructural neuropathology of prion diseases are generally well described. Here we report that alternations of myelinated fibres in hamsters infected either with polioencephalopathic strains of scrapie or panencephalopathic strains of CJD (Echigo-1) are virtually identical and differ only quantitatively. In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres.
6/10
Tytuł oryginału:
Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 2: Astrocytic and macrophage reaction towards axonal destruction.
Autorzy:
Liberski
Paweł P.,
Bratosiewicz-Wąsik
Jolanta,
Gajdusek
D. Carleton,
Brown
Paul
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.131-139, il., bibliogr. s. 137-139
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Świnki morskie
Streszczenie angielskie:
We report hare the microglial (macrophage) and astrocytic reaction in several models of transmissible spongiform encephalopathies (TSEs) or prion diseases. With the low power electron microscopy it was readily apparent that myelinated vacuoles were surrounded by cells and their processes. The latter belonged either to hyperplastic reactive astrocytes or to macrophages. Typically, reactive astrocytes exhibited cytoplasm filled with innumerable glial filaments and, occasionally, other organelles (like cilia) and abundant tortuous intercellular junctions of adhesive plaque junction type. Desmosome-like junctions connecting astrocytic elements were also seen. As described earlier, astrocytic process were occasionally interdigitated with oligodendroglial cells and their processes. Two types of macrophages were readily described. The majority of them exhibited electron-dense cytoplasm and numerous "empty" vacuoles (digestive chambers) containing cellular debris. Occasional vacuoles were surrounded by a thin collar reminiscent of "lyre-like inclusions" of the second type of macrophages. Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae.
7/10
Tytuł oryginału:
How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited.
Autorzy:
Liberski
Paweł P.,
Gajdusek
D. Carleton,
Brown
Paul
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.141-147, il., bibliogr. s. 145-147
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
Streszczenie angielskie:
As in other neurodegenerative diseases such as Alzheimer's disease, neurons in prion diseases or transmisible spongiform encephalopathies (TSEs) die via programmed cell death of which the apoptotic process is relatively well characterized. A subcellular alteration linked to apoptosis is the formation of autophagic vacuoles, which we and others demonstrated in CJD- and scrapie-affected rodent brains. Autophagy may co-exist with apoptosis or may precede it and the process may be induced by apoptosis stimuli. Here, we extend these observations using different model of scrapie and CJD. Both scrapie models (the 265K and 22C-H) demonstrated autophagic vacuoles with the same frequency; hence, they will be described together. While the following changes had been observed simultaneously in different areas of the same sample, this description is organised as if it followed a sequence of events. First, a part of the neuronal cytoplasm was sequestrated by concentric arrays of membrane; that part of the cytoplasm closed by membranes appeared relatively normal but its density often appeared increased. Next, electron density of the central dramatically increased. Then, membranes proliferated within the cytoplasm in a labyrinth-like manner and an area sequestrated by these membranes enlarged and became more complex structure consisting of vacuoles, electron-dense area and areas of normally-looking cytoplasm connected with convoluted membranes. Finally, a large area of the cytoplasm was transformed into a collection of autophagic vascuoles of different sizes. Virtually identical alternations, albeit with much lower frequency, were seen in terminally ill CJD-affected hansters.
8/10
Tytuł oryginału:
Molecular cloning and sequencing of partial cDNA of tumor necrosis factor and p75 tumor necrosis factor receptor of Syrian golden hamster (Mesorcricetus auratus) with the use of universal primers.
Autorzy:
Dobrzańska
Zuzanna,
Więckiewicz
Joanna,
Bigda
Jacek
Źródło:
Acta Bioch. Pol. 2002: 49 (2) s.427-431, il., bibliogr. [15] poz. - 6 Spotkanie Młodych Immunologów Sekcji Polskiego Towarzystwa Immunologii Doświadczalnej i Klinicznej Gdańsk 2000
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
genetyka
immunologia
Typ dokumentu:
tytuł obcojęzyczny
praca związana ze zjazdem
praca doświadczalna
komunikat
Wskaźnik treści:
zwierzęta
chomiki
płeć męska
Streszczenie angielskie:
In this study we cloned and analysed partial cDNA of tumor necrosis factor (TNF) and p75 TNF-R receptor of Syrian golden hamster (Mesocricetus auratus). We obtained a 382-bp sequence of TNF and a 148-bp sequence coding for p75 TNF-R. The primers used for the cloning were designed on the basis of inter-species homology, thus presumably can be used for cloning and analysis of TNF and p75 TNF-R genes of other mammals.
9/10
Tytuł oryginału:
Stres oksydacyjny w nerce chomika syryjskiego poddanego przewlekłej estrogenizacji w obecności syntetycznych aminooksyli : praca doktorska
Autorzy:
Stefaniak
Tomasz, Woźniak Michał (promot.).; Akademia Medyczna w Gadńsku
Źródło:
2002, 134 k. : il., tab., bibliogr. 177 poz., streszcz., maszyn.
Sygnatura GBL:
45/20407
Hasła klasyfikacyjne GBL:
nefrologia
onkologia
endokrynologia
Typ dokumentu:
praca doświadczalna
praca doktorska
Wskaźnik treści:
zwierzęta
chomiki
10/10
Tytuł oryginału:
Estimation of macrophage IL-10 and NO secretion in the cytotoxicity against transplantable melanomas in relation to the progression of these tumours.
Autorzy:
Kozłowska
Krystyna,
Cichorek
Mirosława,
Zarzeczna
Małgorzata
Źródło:
Folia Morphol. 2002: 61 (3) s.127-131, il., bibliogr. 28 poz.
Sygnatura GBL:
301,720
Hasła klasyfikacyjne GBL:
immunologia
onkologia
dermatologia i wenerologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
chomiki
płeć męska
Streszczenie angielskie:
The relationship between the secretion of interleukin 10 (IL-10) and nitric oxide (NO) by hamster peritoneal marcophages and their cytotoxic effects on the cells of those two melanoma lines was studied. The nonuniform reaction of macrophages from hamsters bearing two transplantable melanoma lines has been observed. An increase in the cytotoxicity of macrophages from hamsters bearing the amelanotic melanoma line was accmpanied by an inverse correlation between IL-10 and NO secretion. Such a relationship was not found in the case of macrophages from animals bearing the native-melanotic melanoma line. It is suggested that the phenotypical changes of melanomas connected with their progression modified the cytotoxic and secretory activity of the macrophages with regard to IL-10 and NO.
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