Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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ŻABY
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6
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1/6
Tytuł oryginału:
Model study of toluene diisocyanate effect on transepithelial ion transport.
Autorzy:
Kosik-Bogacka
Danuta Izabela,
Tyrakowski
Tomasz
Źródło:
Med. Sci. Monitor 2002: 8 (5) s.BR187-BR192, il., tab., bibliogr. 36 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
toksykologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
Żaby
in vitro
Streszczenie angielskie:
Toluene disocyanate (TDI), a low molecular weight compound, is commonly known as a factor causing asthma in chemical industry workers. The present study investigated a possible effect of TDI on ion transport using electrophysiological methods aimed at assessment of ion currents occurring in epithelial tissues. The experiemnts were carried out on 119 fragments of isolated frog skin, sampled from 59 specimens of hybrid frog Rana esculenta L. The procedures employed involved transepithelial electrical potential (PD in mV) measuremetn with an Ussing apparatus, modified to enable mechanical stimulation of organs and defined pharmacological actions. Incubation was carried out using Ringer solution and Ringer solution with amiloride and baumetanide. Direct actions of toluene diisocyanate (TDI) were assessed at the time of administering this substance to the Ussing chamber with a peristaltic pump. Based on the model of frog skin tested with Ussing apparatus, administration of TDI to the fluid stimulating preparations incubated with Ringer solution (RH) and with amiloride (AMI) was demonstrated to cause a hyperpolarization invrease after mechanical stimulation. TDI action on isolated frog skin inflicated a change in response to mechanical stimulation, leading to a depolarization. The reaction magnitude of frog skin incubated with bumetanide (BUME) did not chane due to TDI. TDI influences precesses of sodium ion transport in the isolated frog skin model, depending on mechanical stimulation. This indicates that TDI effect on ion transport in epithelial cells depends on C fibres and tachaykinins released from their endings.
2/6
Tytuł oryginału:
Effect of ambroxol on ion transport - a model study.
Autorzy:
Kosik-Bogacka
Danuta I.,
Tyrakowski
Tomasz
Źródło:
Med. Sci. Monitor 2002: 8 (6) s.BR236-BR241, il., tab., bibliogr. 44 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
Żaby
Streszczenie angielskie:
Effect on ambroxol on reflexive physiological reactions of isolated frog skin was studied with elctrophysiological methods designed to assess on currents occurring in epithelial tissues or organs. The experiments permitted to analyze an effect of ambroxol on regulatory mechanisms, which in turn influence the constant electrical potential defined as PD and reversible changes of this potential during mechanical stimulation (marked as dPD). A contribution of sodium- and chlorid eions transport to the value of transepithelial electrical potential of frog skin (before adn after ambroxol administration) has been demonstrated using amiloride - a blocker of sodium ion transport and bumetanide - a blocker of chloride ion transport. The experimental material comprised 34 fragments of hybrid frog (Rana esculenta L.),, representing 14 spcimens. The experiments involved measuring the transepthelial electrical potential (PD in mV) on an isolated frog skin place in an Ussing apparatus. It has been demonstrated that ambroxol influences the processes of ion transport (dPD) which in turn depend on mechanical stimulation. The reaction of hyperpolarization decreased immediately after administration of ambroxol to the stimulating fluid, when transepithelial transport of sodium ion was maintained in the preparations studied. Consequently, no efect of ambroxol on the frog skin incubated wtih amiloride was recorded. It has been demonstrated, based on the experiments carried out in the present study , taht ambroxol can modify processes of ion transport related to activation of sensory receptors...
3/6
Tytuł oryginału:
Effect of capsaicin and dimethyl sulfoxide on ion transport in the selected experimental models.
Autorzy:
Kosik-Bogacka
Danuta I.,
Banach
Bolesław,
Tyrakowski
Tomasz,
Wojciechowska
Iwona
Źródło:
Pol. J. Pharmacol. 2002: 54 (3) s.267-274, il., tab., bibliogr. 46 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
króliki
Żaby
in vitro
Streszczenie angielskie:
The aim of the present work was to determine the changes in ion transport in the selected epithelium-lined organs under influence of mechanical stimuli, and also to assess similarities and differences in reactions to capsaicin and dimethyl sulfoxide (DMSO) between trachea and caecum of rabbit and the skin of frog in this experimental setup. The experiments were conducted on rabbit trachea and caecum, and the skin of frog, Rana esculenta L. The experiments consisted in measuring transepithelial electrical potential (PD in mV) with Ussing apparatus, modified to enable testing of the effects of mechanical stimulation of organs and defined pharmacological treatments. It was demonstrated that the addition of DMSO to the stimulating fluid decreased reversible hyperpolarization (dPD) after mechanical stimulation by at least 50 p.c. in all studied groups. On the other hand, action of capsaicin was dependent on the organ studied as well as on experimental conditions (e.g. type of incubation). Capsaicin decreased PD and reaction to mechanical stimulation in trachea incubated in Ringer solution supplemented with amiloride. On the other hand, it did not influence electrophysiological parameters of the trachea following its incubation with bumetanide. Capsaicin did not change electrical potential or reactivity of rabbit caecum incubated with both amiloride and bumetanide. The administration of capsaicin on frog skin incubated with bumetanide casued inhibition of the reaction to mechanical stimulation, whereas during incubation with amiloride no changes were recorded in PD and dPD of the skin. The present study demonstrated that capsaicin and DMSO could modify processes of ion transport dependent on mechanical stimulation.
4/6
Tytuł oryginału:
Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.
Autorzy:
Benoit
Evelyne,
Mattei
Cesar,
Ouanounou
Gilles,
Meunier
Frederica A.,
Suput
Dusan,
Le Gall
Frederic,
Marquais
Michel,
Dechraoui
Marie Y.,
Molgo
Jordi
Źródło:
Cell. Mol. Biol. Lett. 2002: 7 (2) s.317-321, bibliogr. 15 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
Sygnatura GBL:
306,513
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca związana ze zjazdem
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
Żaby
Streszczenie angielskie:
This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cationselective pores and indirectly affect the functioning of the Na+-Ca++ exchanger.
5/6
Tytuł oryginału:
Effect of thyroxine on some digestive enzymes of the adult male toad, Bufo melanostictus.
Autorzy:
Bhattacharyya
Sanat K.,
Chaki
Korak K.,
Misra
Kamales K.
Źródło:
Folia Biol. 2002: 50 (1/2) s.83-90, tab., bibliogr. s. 89-90
Sygnatura GBL:
302,991
Hasła klasyfikacyjne GBL:
endokrynologia
gastroenterologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
Żaby
płeć męska
Streszczenie angielskie:
Thyroxine is known to play an important role during the developmental process of amphibians. The present work is designed on the hypothesis that a functional relationship exists between the thyroid gland and digestive physiology in the adult toad. Three doese of thyroxine (25 ćg/100 g; 50 ćg/100 g; 100 ćg/100 ćg body weight) were orally administered daily to the adult male toad, Bufo melanostictus and changes in -amylase, pepsin, trypsin, and esterase activities of the different zones of the digestive tract, pancreas and liver were observed. The observations were made on 7, 15, and 30 days of thyroxine treatment. The result shows that the dose of 25 ćg increases the enzyme activities in the gastrointesinal tract, liver and pancreas of 7 days treatment. However, prolonged treatment with all the doses shows little effect on these enzymes. The pattern of changes in the enzymatic activities in the digestive tract of the adult male toads show more advanced compartmentalizaiton than that of fishes. It is also found that site-specific enzyme production is not pronounced in this amphibious vertebrate. It is proposed that a positive functional relationship between thyroxine and digestive enzymes exists in the adult male toad.
6/6
Tytuł oryginału:
Porównawcze badania aktywności esterazy aspirynowej i cholinesterazy surowicy ludzkiej krwi : praca doktorska
Autorzy:
Goździalska
Anna, Pajdak Władysław (promot.).; Uniwersytet Jagielloński Collegium Medicum, Zakład Immunochemii w Krakowie
Źródło:
2002, [8], 124 k. : il., tab., bibliogr. 132 poz., streszcz., maszyn.
Sygnatura GBL:
45/19879
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca kliniczna
badanie porównawcze
praca doświadczalna
praca doktorska
Wskaźnik treści:
ludzie
ptaki
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
zwierzęta
bydło
króliki
myszy
szczury
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