Wynik wyszukiwania

historia XIX wieku

historia XX wieku

2/2523

Tytuł oryginału: Are there any disturbances in vestibular organ of children and young adults with type I diabetes?
Autorzy: Gawron W., Pośpiech L., Orendorz-Frączkowska K., Noczyńska A.
Źródło: Diabetologia 2002: 45 (5) s.728-734, il., tab., bibliogr. 28 poz.
Sygnatura GBL: 312,048

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Aims/hypothesis. The aim of the work was to evaluate the vestibular organ condition in children and young adults suffering from Type I (insulin-dependent) diabetes mellitus. Methods. The group examined consisted of 95 children and young adults aged from 6 to 28 years with Type I diabetes diagnosed. The diabetic group was divided into subgroups according to duration of the disease, compensation of the disease, and presence and character of hypoglycaemic incidents, and presence of diabetic complications. The control group consisted of 44 healthy children and young adults aged 6 to 28 years. After collecting detailed medical history in each case an electronystagmographic test was performed using the computed two-canal electronystagmographer. Results. Within the diabetic group 6 patients complained about vertigo and balance disorders. Spontaneous nystagmus occurred in 10 cases, positional one in 21 cases. Impaired optokinesis occurred in 36 cases and impaired eye tracking test in 33 cases. In caloric tests there was partial canal paresis in 4 cases and directional preponderance in 7 cases. Conclusion/interpretation. Metabolic disturbances present in Type I diabetes cause disturbances in different parts of vestibular organ but mostly in its central part. Comparing disturbances in the vestibular organ with clinical and biochemical parameters characterising diabetes, the range of vestibular organ impairment in diabetes mellitus type 1 seems to depend mainly on the presence and character of hypoglycaemic incidents and the duration of the disease and to some extent on the compensation of diabetes.

3/2523

Tytuł oryginału: Antiaggregatory activity of hypoglycaemic sulphonylureas.
Autorzy: Siluk D., Kaliszan R., Haber P., Petrusewicz J., Brzozowski Z., Sut G.
Źródło: Diabetologia 2002: 45 (7) s.1034-1037, il., tab., bibliogr. 11 poz.
Sygnatura GBL: 312,048

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Aims/hypothesis. Vascular complications observed in diabetes are often related to altered platelet functions. The most widely used hypoglycaemic drugs for treating Type II (non-insulin-dependent) diabetes mellitus are sulphonylurea derivatives. The purposes of this study were to evaluate the inhibitory effects of hypoglycaemic agents on platelet aggregation, to measure their lipophilicity and identify their structural parameters which assess their antiaggregatory activity. Methods. An antiaggregatory test in vitro was carried out for 13 sulphonylurea derivatives. Aggregation of platelets, incubated with the agents at concentrations varying from 7.5 to 480 ćmol/l, was induced by 10 ćmol/l ADP. Drug lipophilicity parameter, log kw, was measured by gradient HPLC and the agents were subjected to molecular modelling. Results. The most pronounced inhibition of platelet aggregation was by glimepiride, gliclazide, gliquidone, glibenclamide and compound 2A. The IC25 values were 15.9, 18.6, 20.4, 28.5 and 34.7 ćmol/l, respectively. Quantitative structure-activity relationships indicate that antiaggregatory activity is mainly affected by electronic and not by lipophilic properties of the agents. Conclusion/interpretation. Glimepiride appeared to be a more potent ADP-induced platelet aggregation inhibitor in vitro than gliclazide. Antiaggregatory activity was shown for gliquidone and confirmed for glibenclamide. The QSAR analysis supports the hypothesis of a free radical mechanism of action of sulphonylurea derivatives previously suggested for gliclazide.

4/2523

Tytuł oryginału: History and present situation of Paediatric ENT Surgery in Poland and in other Central East European countries.
Autorzy: Chmielik Mieczysław, Bielicka Anna, Ranocha Cezary, Chmielik Lechosław
Źródło: New Med. 2002: 5 (2) s.46-48, tab., bibliogr. 5 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: One of the first paediatric ENT centres in the world was the research group managed by Jan Danielewicz in Warsaw. It was organised on the basis of progress clinics and paediatric ENT wards, and a programme of specialisation was established (1, 2). Almost simultaneously, in the sixties of the twentieth century, centres for paediatric ENT were established in Prague, Berne, Bratislava, Budapest, Bucharest and Sophia. In the nineteen-seventies these were in touch with the centre for paediatric ENT in Italy, which was the pioneer in this speciality in West Europe. The effect of this contact was the creation of the European Federation of Oto-Rhino-Laryngology Societies, and the International Federation of Oto-Rhino-Laryngological Societies (IFOS), and further dynamic progress in this specialisation.

5/2523

Tytuł oryginału: Tracheotomy in children - indications and complications.
Autorzy: Zawadzka-Głos Lidia, Chmielik Mieczysław
Źródło: New Med. 2002: 5 (2) s.49-52, tab., bibliogr. 22 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Tracheostomy is a life-saving procedure when pertbrmecl with an appropriate indication and surgical technique. There is a limited indication for tracheostomy procedures in paediatrie surgery. It is rarely applied to the paediatric patient because they can be kept intuhated for a longer period compared to adults. Indications for tracheostomy are prolonged intubation, subglotie stenosis, general body trauma, tracheomalasia, cervical tumour pressing the trachea and larynx, congenital diseases of the larynx, burn injuries of the trachea, and foreign body aspiration. In the last decade the number of cases with tracheotomy increased due to the development of new intensive care units, the use of mechanical ventilation, and the increasing number of patients needing prolonged ventilation support. Tracheotomy in children lias been associated with significant operative and post-operative complications. When long-term tracheotomy is needed, parent education, together with special equipment and environment may allow the return of the tracheotomised child to home in secure conditions.

6/2523

Tytuł oryginału: Nasal and sinus diseases in children - surgical treatment.
Autorzy: Chmielik Mieczysław, Brożek Eliza
Źródło: New Med. 2002: 5 (2) s.53-54, bibliogr. 10 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

praca kliniczna

Wskaźnik treści:

ludzie

Streszczenie angielskie: Plastic surgery of the lateral nasal wall in children has been performed in Warsaw Paediatric ENT Clinic since 1995. There have been 121 operations. They consisted of conservative reconstruction of congenital or acquired defects in this area. In most eases a decrease in the number of upper airways infections and permanent improvement of nasal patency was attained. None of the cases lias shown any inhibitory influence from these procedures on craniofacial development. The principles of accomplishing conservative plastic surgery of the nasal mucous membrane are defined.

7/2523

Tytuł oryginału: Laryngeal haemangioma in children.
Autorzy: Chmielik Mieczysław, Zając Beata
Źródło: New Med. 2002: 5 (2) s.55-57, bibliogr. 22 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Haemangiomas and vascular malformations located in the larynx are rare hut potentially life-threatening conditions, because they compromise the airway. The authors present the clinical symptoms and method of diagnostic evaluation of these lesions. Various techniques for the treatment oflaryngeal haemangioma are discussed, but no single approach has universal acceptance.

8/2523

Tytuł oryginału: Assessment of hearing in children in postoperative treatment of choanal atresia.
Autorzy: Zawadzka-Głos Lidia, Bielicka Anna, Chmielik Mieczysław
Źródło: New Med. 2002: 5 (2) s.58-60, tab., bibliogr. 12 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

praca kazuistyczna

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Choanal atresia is a congenital abnormality often coexisting with other developmental abnormalities. The treatment of choice his condition is surgical restoration of choanae patency using a transnasal or transpalatal operative approach. After ;ical treatment, separators are fixed for several weeks in the posterior choanae and nasopharynx. Surgical transpalatal rvention and extended retention of separators in the posterior choanae and nasopharynx may cause auditive tube unction and otitis media with effusion. The aim of this work was the estimation of the occurence of otitis media with sion in children under post-operative treatment after choanal atresia depending on the surgical approach applied. immary of the period 1959-2002 in the Department of Paediatric Otorhinolaryngology in Warsaw shows that 175 operations s performed because of choanal atresia. A group of 11 children operated on choanal atresia between 1996-2002 was nined. Acoustic impedance audiometry was performed in all children. Bilateral choanal atresia was recognised in 4 children, unilateral choanal atresia in 7 children. A tympanomctry curve type B was obtained in 4 children, but a tympanometry curve type A was found in 7. In the examined group we did not find a dependence between the type of operative approach in surgical treatment of choanal atresia and otitis media with effusion occurrence.

9/2523

Tytuł oryginału: Tonsil operations in children - indications and contradictions.
Autorzy: Chmielik Mieczysław, Bielicka Anna, Brożek Eliza
Źródło: New Med. 2002: 5 (2) s.61-63, bibliogr. 10 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Adenoidectomy, tonsillectomy and tonsillotomy were and still are the most common surgical procedures performed in Paediatric Otorhinolaryngology. The aim of this study is to justify the use of these methods in particular cases, and also specifying the complications that might occur in the postoperative period. The indications for the procedures are divided into definite and relative, while the complications are separated into two groups, early and late. The information given in the text is based on the experience of the Paediatric ENT Clinic of the Medical University of Warsaw, and the available literature.

10/2523

Tytuł oryginału: Laryngeal papillomatosis in children and their surgical treatment.
Autorzy: Zawadzka-Głos Lidia, Chmielik Mieczysław, Bielicka Anna
Źródło: New Med. 2002: 5 (2) s.64-66, bibliogr. 17 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Laryngeal papillomas in children constitute a disease of viral aetiology caused by Human Papilloma Virus. Even though the changes arc histologically benign, their exophytic growth may lead to a critical airway obstruction and the child's suffocation. Due to the tendency to recur, lack of causal treatment, and risk of malignancy the optimal method of treating this condition is still being sought. The study presents methods applied nowadays in the treatment of laryngeal papillomas; especially, it concentrates on a classical papillotomy and its main advantage: the diminished risk of scar formation leading to laryngeal stenosis and vocal fold injury with speech disorders.

11/2523

Tytuł oryginału: Vertigo and dizziness in children - diagnostic problems.
Autorzy: Chmielik Jolanta, Chmielik Mieczysław, Zając Beata, Gabryszewska Anna, Szapłyko Waldemar
Źródło: New Med. 2002: 5 (2) s.67-70, il., bibliogr. 11 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

praca kliniczna

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The purpose of the study was to review clinical presentation, diagnostic methods, and conditions causing vertigo and dizziness in children. The authors report a retrospective review of 70 children diagnosed in the ENT Department or Outpatient Clinic in the Department of Paediatric Neurology. The differential diagnosis of dizziness and vertigo in children requires a multidisciplinary approach. Close co-operation between the otolaryngologist, paediatrician, neurologist and ophtalmologist allows the best chance of accurate diagnosis. From an analysis of the results, a diagnostic approach to the dizzy child is suggested, and the most frequent conditions causing vertigo in children are discussed.

12/2523

Tytuł oryginału: Ventilating tube insertion in the treatment of otitis media with effusion in children.
Autorzy: Dębska Małgorzata, Bielicka Anna, Chmielik Mieczysław
Źródło: New Med. 2002: 5 (2) s.71-72, bibliogr. 17 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The authors present methods of surgical treatment of otitis media with effusion in children. The advantages and complications of ventilating tube insertion are given particullar attention.

13/2523

Tytuł oryginału: Clinical aspects of ethmoiditis.
Autorzy: Chmielik Mieczysław, Gabryszewska Anna
Źródło: New Med. 2002: 5 (2) s.73-75, bibliogr. 12 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Ethmoiditis is a condition which any GP may meet in his practice. In this paper we describe the pathomechanisms which lea( to acute and prolonged sinusitis in children, the diagnostics, and prognosis. Particular attention is paid to complications which may be tragic in children. We also consider possible treatments and management when complications occur.

14/2523

Tytuł oryginału: Frontometaphyseal dysplasia in a 3 5/12 year-old girl and in the "unaffected mother".
Autorzy: Marik Ivo, Kozlowski K.
Źródło: New Med. 2002: 5 (2) s.76-79, il., bibliogr. 15 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

praca kazuistyczna

Wskaźnik treści:

dzieci 2-5 r.ż.

płeć żeńska

Streszczenie angielskie: We report a girl with fromtometaphyseal dysplasia in whom the first phenotypic abnormality noted at the age of 3 months was metopic suture torus. At the end of the first year of life knock knee deformity and torsion of the legs was noted and this progressed in spite of orthotic treatment. The diagnosis of frontometaphyseal dysplasia was established at the age of 3 years 5 months. Family studies revealed that the mother, supposed to be normal was also affected. Previously unreported clinical manifestations and radiographic findings are documented to further delineate and expand the spectrum of the disorder.

15/2523

Tytuł oryginału: A new, distinctive from of spondylo-epi-metaphyseal dysplasia.
Autorzy: Beighton P., Kozlowski K.
Źródło: New Med. 2002: 5 (2) s.80-82, il., bibliogr. 5 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

praca kazuistyczna

Wskaźnik treści:

dzieci 2-5 r.ż.

płeć męska

Streszczenie angielskie: Spondylo-epi-metaphyseal dysplasias are a group of complex disorders, most of which defy classification. We report a patient with distinctive radiographic features who presents a previously undescribed form of spondylo-epi-metaphyseal dysplasia.

16/2523

Tytuł oryginału: Hallucinations, illusions, and other visual disturbances in neurology.
Autorzy: Brzecki Andrzej, Kobel-Buys Krystyna, Buys Guido
Źródło: New Med. 2002: 5 (2) s.83-88, il., bibliogr. 57 poz.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The authors describe the visual pathway and especially the posterior part of the optic visual radiation and visual representation in the cuncus of the occipital cortex. Almost the entire visual tract is supplied by the posterior cerebral artery, except for central vision representation, which is supplied by a branch of the middle cerebral artery. Therefore, damage to the visual pathway of one hemisphere may cause hetcronymous hemianopsia or quadrantanopsia and, less frequently, visual hallucinations and illusions. Hallucinations and illusions may also occur - exempli gratia - in infectious encephalopathies, poisonings, sleep disorders and psychoses. In particular, stimulation of the temporal lobe by toxins or drugs having dopamincrgic, semtoninergic or adrenergic actions (frequently true or ,,false" neurotransmitters) may also cause them. Examples of paintings done by artist under the influence of some hallucinogens has been presented. Prosopgnosia and prosopagnosia have been discussed. Prosopagnosia may be caused by an injury the right hemisphere. Anosognosia of the left part of the body and the left visual field have to been also discussed. A case study of a patient with visual hallucinations and illusions of his own enormous extremities in the course of thrombosis of the posterior cerebral artery has been mentioned. Also, in connection with this theme, we discussed anosognosia of the left part of the body and left visual field spatial neglect, cortical blindness etc. and we mentioned border zone infarcts as a new problem of vascular diseases in elderly patients. ...

17/2523

Tytuł oryginału: Analihz pihdgotovki sihmejjnikh lihkarihv v dejakikh krajinakh svihtu ta problemi vprovadzhennja sihmejjnoji medicini v Ukrajinih.
Tytuł angielski: Comparative characteristic of family medicine in some countries and the possibility of introduction them in Ukraine.
Autorzy: Chopejj Ih. V.
Źródło: New Med. 2002: 5 (1) s.3-9, bibliogr. 11 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

organizacja ochrony zdrowia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: In the paper presented the various models of family medicine. There are done the conclusion about the adequate model for Ukraine in the transitive economic period.

18/2523

Tytuł oryginału: Dosvihd nadannja pervinnoji mediko-sanihtarnoji dopomogi khvorim na khronihchnih obstruktivnih zakhvorjuvannja legen, jajkih poterpihli vnasljidok ekologihchnoji katastrofi - povenih.
Tytuł angielski: Experience of the primary medical and sanitary help render to patients with chronic obstructive pulmonary diseases, who were suffering from ecological disaster - flood.
Autorzy: Rogach Ih. M., Lemko Ih. S., Melega-Zajac K. P., Melega O. O., Lemko O. Ih., Brich V. D., Ljakh V. V., Kihrejj K. Ja, Gabor M. L., Kazankevich V. P.
Źródło: New Med. 2002: 5 (1) s.10-12, bibliogr. 6 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The peculiarities of chronic obstructive pulmonary diseases in patients who were suffering from flood were studied in dependence influence's nature of the ecological disaster factors. The ways and means of medical and sanitary help efficiency's increase were shown in account of nosology, disease's severity, nature of flood factors influence, period, which has passed after flood.

19/2523

Tytuł oryginału: Kontrol za efektivnihstju trivaloji antigihpertenzivnoji terapihji enalaprilom v praktichnihjj robotih sihmejjnogo lihkarja.
Tytuł angielski: Checking the effcacy of prolonged antihypertention therapy with enalapril in practical woru of a family doctor.
Autorzy: Nejjko Je. M., Orinchak M. A., Seredjuk N. M., Gorban Je. M., Vakaljuk Ih. P., Aleksandruk D. P., Jacishin R. Ih., Vihrstjuk N. G., Seredjuk V. N., Glushko N. L., Artemenko N. R., Lihbrik O. Ja., Cherkashina O. Je.
Źródło: New Med. 2002: 5 (1) s.13-15, bibliogr. 6 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: 137 patients in the middle and older age with arterial hypertension (AH) of the P and Sh stage were observed. The speading of AH in different regions of Precarpathia in dependance from climatical - geografical and socioeconomical conditions was studied. It was stated that the indexes of the daily monitoring of blood preassure are informational prognostical criterial of AH running and also are the criteria of the effectivness of the antihypertensive therapy. The effectiveness of the long time use of the angiotensin-converting enzyme inhibitor of enalapri in different age groups of the patients was proved. The study of psychological condition of the patient with the help to the questioneer may serve as the criteria of valuing the effectiveness of healing and social rehabilitation of the AH patients. The recommendation for the family doctors concerning healing and the prevention of the complicates of the AH on the base of the researth results were worked out.

20/2523

Tytuł oryginału: Suchasnih programi monihtoringu zakhvorjuvan' organihv travlennja u prakticih lihkarja sihmejjnoji medicini.
Tytuł angielski: The modern programs of the monitoring of alimentary tract's diseases in outpatient's practice of a general practitioner.
Autorzy: Chernobrovijj V. M., Melashhenko S. G., Palihjj Ih. G., Pihvtorak N. A., Zajika S. V., Skripka A. A., Fedzhaga Ih. V., Kavka S. O., Kosenko S. V., Fostakovs'kijj D. S., Chernova Ih. V., Morozova O. Ih., Burka N. V., Kolihsnik S. P.
Źródło: New Med. 2002: 5 (1) s.16-20, bibliogr. 9 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The article is devoted to the experience of treatment widespread alimentary tract's diseases in outpatient's practice by using methods of control gastrointestinal disorders: acid-related (hyperacidity, hypoacidity, gastroesofageal and duodenogastral reflux) and nonacid-related (contamination of microogranisms, vertebrogenic).

21/2523

Tytuł oryginału: Rol' sihmejjnoji medicini v optimihzacihij roboti po profihlakticih gostrikh porushen' mozkovogo krovoobihgu.
Tytuł angielski: The role of family medicine in optimization of prevention of acute cerebral circulatory disturbans.
Autorzy: Pulik O. R., Chopejj I. V., Pulik R. O.
Źródło: New Med. 2002: 5 (1) s.21-23, bibliogr. 9 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: In the article the various models of optimization of prevention of acute cerebral circulatory disturbances are presented. The significant role of the "patient's diary" has been shown.

22/2523

Tytuł oryginału: Ocihnka antigihpertenzivnoji dihji betaksolola (lokrenu) v gostrikh farmakodinamihchnikh testakh u khvorikh na arterihal'nu gihpertenzihju, shho perenesli ihnfarkt mihokarda (za danimi dobovogo monihtoruvannja arterihal'nogo tisku).
Tytuł angielski: The studing of arterial blood pressure monitoring results under the influence of lokren revealed its significant antihypertensive efficacy both after the first 20 mg dose and after 2-weeks course of treatment.
Autorzy: Vakaljuk I. P., Stasjuk L. B., Zvonar P. P., Lihbrik O. M.
Źródło: New Med. 2002: 5 (1) s.24-27, il., bibliogr. 8 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli 45-64 r.ż.

Streszczenie angielskie: The estimation of antihypertensive efficacy of lokren during the pharmonodynamic tests in patients with arterial hypertension, after acute myocardial infraction (by data of arterial blood pressure monitoring). While treating patients with 20 mg of Lokren the decreasing of systolic and diastolic arterial blood pressure variability and heart rate was observed.

23/2523

Tytuł oryginału: Analihz vrodzhenikh vad rozvitku plodu v oblasnomu centrih Zakarpattja ta jikh znachennja v prakticih sihmejjnogo lihkarja.
Tytuł angielski: Some data of ultrasonic investigation of pregnant women and analysis of natal defects of fetus during the time period of 1993-1999 in the town of uzhgorod.
Autorzy: Chopejj O. Ih., Slivka N. V., Chopejj K. Ih.
Źródło: New Med. 2002: 5 (1) s.28-31, tab., bibliogr. 5 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

radiologia

Typ dokumentu:

badanie porównawcze

tytuł obcojęzyczny

Wskaźnik treści:

płód

noworodki

Streszczenie angielskie: We studied the data of prenatal ultrasound diagnostics of abnormalities in fetus. Coincidence of prenatal and postnatal diagnoses was registered in 92 p.c. Structure and index of rate of abnormalities in fetus were compared with the data of monitoring in newborns. The differences have been analyzed.

24/2523

Tytuł oryginału: Optimihzacihja navchal'nogo procesu lihkarihv zagal'noji praktiki na ciklih "kardihologihja" shljakhom vikoristannja suchasnikh ihnformacihjjnikh tekhnologihjj.
Autorzy: Glushko L. V., Fedorov S. V., Makovec'ka T. Ih., Ostrovs'kijj M. M., Berezovs'ka L. A.
Źródło: New Med. 2002: 5 (1) s.32-33, bibliogr. 3 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The demands made to quality of training physicians to be are defined in the programs and directives of the Ministry of Public Health and Education of Ukraine. One of the factors directed to profound medical subjects studying is subsequent optimizing the training process, namely raising use of information technologies in teaching. This article gives facts and figures concerning forming postgraduate medical training of general practicioners in cardiology cycle using the modern information technologies.

25/2523

Tytuł oryginału: Rezultati vivchennja pokaznikihv pH slizovoji obolonki tovstoji kishki ta vikoristannja v klihnihchnihjj prakticih jikh zmihni pihd vplivom lihkuvannja.
Tytuł angielski: PH-metry in the patients having irritable bowel syndrome and variable pH after treatment.
Autorzy: Rusin Ih. S., Ihl'ko A. V., Ploskihna V. Ju., Kanchihjj V. M., Rihshko V. V.
Źródło: New Med. 2002: 5 (1) s.34-35, tab., bibliogr. 4 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The methods and the results of transcolonoscopic pH-metria of the different parts of bowels, changes of this indices attached to diseases of this part of the gastrointestinal tract under influence of different complexes of treatment are being discussed in this publication.

26/2523

Tytuł oryginału: Docihl'nihst' vikoristannja al'ternativnikh metodihv lihkuvannja khvorikh kardihologihchnogo profihlju v prakticih sihmejjnogo lihkarja.
Tytuł angielski: The expediency of alternative treatment methods used in a family doctor's practice.
Autorzy: Shkoda-Ul'janova N. V., Dolgosh M. Ju., Panas S. V.
Źródło: New Med. 2002: 5 (1) s.36-39, il., tab., bibliogr. 9 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Taking into consideration a significant number of the adverse effects, which appear after the treatment of the cardio - vascular diseases, namely: 1) tolerance; 2) cancellation syndrome; 3) paradoxical effect; it is suggested, as an alternative, to use angio - injeel, which could be applied both independently, as a monotherapy, and with other traditional remedies. The dosage, in this case, is decreased, contributing to the less number of cases of the aversive effects.

27/2523

Tytuł oryginału: Vivchennja ta mozhlivostih lihkuvannja gelihkobakterihozy v rodinakh khvorikh z urazhennjam gastrodyodenal'noji zoni.
Tytuł angielski: Study and opportunity of helicobacteriosis treatment in families of the patients with gastroduodenal disorders.
Autorzy: Kolesnik P. O., Chopejj Ih. V., Rubcova Je. Ih., Dolgosh M. Ju., Drozd S. Ih., Knishev V. Ih., Kharitonova Z. B., Kuz'mik V. M.
Źródło: New Med. 2002: 5 (1) s.40-44, bibliogr. 12 poz., sum.
Sygnatura GBL: 313,682

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The main theme of the article contains analysis of intrafamiliar clustering and transmission which is implicated as a major route for acquisition of Helicobacter pylori infection. The occurrence of digestive disorders in household members of the patients with chronic gastritis and duodenal ulcer disease families was observed by clinical and instrumental investigation. It proves the high risk of digestive disorders, associated with Helicobacter pylori, in the household members of the index patients. The results of the analysis prove the necessity of all-family eradication treatment in order to avoid reinfection, intrafamiliar clustering and transmission of Helicobacter pylori infection. It can also reduce the risk of digestive disorders, associated with Helicobacter pylori, in the household members of the index patients. The household members and the index patients treatment by the schedule list (which included omeprasole, augmentine, cyprofloxacine during 7 days) caused high eradication effect observed by invasive tests and was mostly alwaysaccompanied by changes in Ig G titres.

28/2523

2002
Tytuł polski: Probabilistic causal models in medicine: application to diagnosis of liver disorders : praca doktorska
Autorzy: Oniśko Agnieszka, Bobrowski Leon (promot.).; [Akademia Medyczna w Białymstoku]
Źródło: 2002, [1], X, 140 k. : il., tab., bibliogr. 158 poz., sum., maszyn.
Sygnatura GBL: 45/23902

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

praca doktorska

tytuł obcojęzyczny

Wskaźnik treści:

29/2523

Tytuł oryginału: Medical humanities in Central and Eastern Europe : the example of Poland
Autorzy: Szawarski Zbigniew
Źródło: W: Integration of medical humanities into the education of health care professionals - Vilnius, 2002 s.17-23 - Włączenie humanistyki medycznej do kształcenia personelu służby zdrowia Wilno 28-29.06. 2002 - Oddzielna numeracja stron tekstu litewskiego w odwrotnym kierunkuTytuł odwróconej odkładki także w jęz. litewskim
Sygnatura GBL: 555,550

Typ dokumentu:

30/2523

Tytuł oryginału: Assessment of long-term effects of exposure to toluene based on the analysis of selected behavioral responses with particular reference to the ability to trigger behavioral hypersensitivity in rats.
Autorzy: Wiaderna Dorota, Tomas Tadeusz
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.239-245, il., bibliogr. 20 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Toluene is a major component of numerous commercial organic solvent formulations. It is often listed among the chemicals capable of producing the organic solvent syndrome and a neurobehavioral hypersensitivity condition. The hypersensitivity condition (continued long-term intensification of some behavioral reactions in response to pharmacological or environmental stressor) is usually associated with the increased tonus of the functional dopaminergic system. The aim of our current research was to determine whether, under conditions of inhalation exposure, toluene can produce long-term behavioral changes or modify the intensity of the behavioral response to apomorphine, a dopaminergic receptor agonist. In our experiment, male rats were exposed to 25, 100 and 250 ppm toluene for 4 weeks (5 days/week, 6h/day). The following behaviors were tested: finding water in a radial maze; open field motor activity; acquiring the conditional response of passive avoidance; sensitivity to a thermal pain stimulus (hot plate test) and changes in this sensitivity caused by stress; and acquiring the conditional response of two-directional active avoidance. The behavioral response to apomorphine, i.e. the increased spontaneous locomotor activity, was assessed on day 10 after the termination of the exposure in the rotary drum test. In the behavioral experiment, significant differences between groups were recorded only for hot plate test; in the 100 and 250 ppm rats, electric-shock-related anxiety response was stronger than in the control group. In the experiment using pharmacological provocation...

31/2523

Tytuł oryginału: Effects of occupational exposure to a mixture of solvents on the inner ear: a field study.
Autorzy: Sułkowski Wiesław J., Kowalska Sylwia, Matyja Wojciech, Guzek Wojciech, Wesołowski Wiktor, Szymczak Wiesław, Kostrzewski Przemysław
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.247-256, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Some clinical and laboratory studies that industrial solvents such as toluene, styrene, xylene, trichloroethylene and carbon disulfide or their mixtures may affect the inner ear, although the mechanism of this process is still not well understood. The aim of this investigation was to assess the incidence of hearing and vestibular disorders (using modern audiological and vestibular tests) in 61 workers exposed to a mixture solvents at the production of paints and varnishes; the control group included 40 age-matched non-exposed subjects. Environmental and biological monitoring revealed that the most significant exposure can be attributed to the following mixture constituents: ethylbenzene, xylene and trimethylbenzene isomers such as pseudocumene, mesitylene and hemimellitene. Electronystagmographic examinations showed the symptoms of vestibular dysfunction, as well as the decreased duration, amplitude and slow phase angular velocity of induced nystagmus in 47.5 p.c. of the subjects exposed versus 5 p.c. of controls. This was accompanied by sensorineural high frequency hearing loss, identified by means of pure tone audiometry in 42 p.c. of those exposed versus 5 p.v. controls, and reduced amplitudes of transiently evoked and distoration-product otoacoustic emissions. The findings closely correspond with the rate total exposure to the solvent mixture. A possible mechanism responsible for ototoxicity of solvents is discussed.

32/2523

Tytuł oryginału: Hospitalizations among teachers in Denmark, 1981-1997.
Autorzy: Hannerz Harald, Albertsen Karen, Tchsen Finn
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.257-266, il., tab., bibliogr. 61 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:

medycyna pracy

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: ll systems and organs of the body were statistically significant lower among teachers compared with other economically active people of Denmark.

Streszczenie angielskie: It is a common notion that teachers constitute a group at high risk of occupational stress, but the potential health consequences of the assumed high stress levels are still poorly illuminated. The aim of the present study was to investigate morbidity among Danish teachers. Cohorts of Danish teachers of primary, secondary and vocational schools, aged 20-59 years in 1981, 1986, 1991 and 1994, were formed to calculate age standardized hospitalization ratios (SHRs) and time trends (1981-1997) for a large variety of diagnostic aggregations. Statistically significantly low SHRs for the major disease categories: neoplasms, diseases of the nervous, circulatory, respiratory, digestive and musculoskeletal systems were found both for man and women. We also found significantly low SHRs for the aggregated diagnostic group "injury and poisoning" in men and for diseases of the nervous and sense organs in women. Age standardized hospitalization rates with respect to diseases observed in practically all systems and organs of the body were statistically significantly lower among teachers compared with other economically active people of Denmark.

33/2523

Tytuł oryginału: Mortality study of workers compensated for asbestosis in Poland, 1970-1997.
Autorzy: Szeszenia-Dąbrowska Neonila, Wilczyńska Urszula, Szymczak Wiesław, Strzelecka Alicja
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.267-278, tab., bibliogr. 21 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The aim of the study was to assess the risk of asbestos-related malignancies among persons with diagnosed asbestosis. The study covered a cohort composed of 907 men and 490 women afficted by asbestosis, diagnosed in 1970-1997. The follow-up of the cohort continued until 31 December 1999. In all, 421 deaths were registered and causes of death were retrieved for 93.3 p.c. of the deceased. A significantly increased mortality was observed both in the male (300 deaths; SMR = 127; 95 p.c. CI: 113-142) and female (121 deaths, SMR = 150; 95 p.c. CI: 124-179) cohorts. The elevated number of deaths in the male and female cohorts were noted mainly due to respiratory diseases (men: 42 deaths; SMR = 344; 95 p.c. CI: 248-465 women: 20 deaths, SMR = 789; 95 p.c. CI: 482-1219) malignant neoplasms (men: 91 deaths, SMR = 146; 95 p.c. CI: 118-179; women: 34 deaths, SMR = 159; 95 p.c. CI: 110-222), including lung cancer (men: 39 deaths, SMR = 168; 95 p.c. CI: 119-230; women: 13 deaths, SMR = 621; 95 p.c. CI: 331-1062) and pleural mesothelioma (men: 3 deaths, SMR = 2680; 95 p.c. CI: 553-7832; women: 3 deaths, SMR - 7207; 95 p.c. CI: 1031-14612). Taking into account a cumulative dose of fibres, it was found that a significantly increased mortality from lung cancer and pleural mesothelioma applied to persons exposed to a dose above 25 f-y/ml. The results indicate that persons with asbestosis are at higher risk of developing malignant neoplasms, especially lung cancer and mesothelioma.

34/2523

Tytuł oryginału: Lung function and surface electromyography of intercostal muscles in cement mill workers.
Autorzy: Meo Sultan A., Azeem Muhammad A., Ghori Moinuddin G., Subhan Mirza M. F.
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.279-287, tab., bibliogr. 48 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:

toksykologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Impairment of pulmonary function in cement mill workers has been previously reported without considering a variety of parameters that can help evaluate more thoroughly the effect of cement dust on the respiratory system. In addition, an integrated approach has not been considered to assert the involvement of respiratory muscles. Therefore, in the present study spirometry and surface electromyography (SEMG) of intercostal muscles were used for indicating pulmonary impairment. In this study, a group of 50, apparently healthy volunteers, male cement mill workers aged 20-60 years with exposure of 13 years on average, were randomly selected. They were matched with another group of 50 control healthy male subjects in terms of age, height, weight and socioeconomic status. Both groups met the standard exclusion criteria. Spirometry was performed on an electronic spirometer, while SEMG of intercostal muscles was performed by using a chart recorder. The results demonstrated statistically significant reduction in lung function parameters i.e., force vital capacity (FVC) (p 0.0005); force expiratory volume in first second (FEV1) (p 0.0005); peak expiratory flow (PEF) (p 0.005); and maximum voluntary ventilation (MVV) (p 0.0005) in cement mill workers, when compared with controls. However, the FEV1/FVC ratio was significantly higher (p 0.025) in cement mill workers. Similarly, the parameters obtained from SEMG of intercostal muscles, i.e. number of peaks (NPO) (p 0.0005); maximum peak amplitude (MPA) (p 0.0005); peak to peak amplitude (PPA) (p 0.0005)...

35/2523

Tytuł oryginału: Occupational exposure to organic dust associated with municipal waste collection and management.
Autorzy: Krajewski Jan A., Tarkowski Stanisław, Cyprowski Marcin, Szarapińska-Kwaszewska Jadwiga, Dudkiewicz Bożena
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.289-301, il., tab., bibliogr. 40 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:

toksykologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The aim of the study was to assess the occupational exposure of workers employed in the municipal waste collection and management industry. Air samples were collected in the workers' breathing zone; two samples were collected parallely. The assessment concerned exposure to organic dust, endotoxins, bacteria and fungi. The questionnaire data showed that workers found themselves in good or very good health. They also regarded noise, dustiness, odor, physical effort and changeable atmospheric conditions as the most strenuous factors. The highest dust concentrations were observed on the sites of waste collection (mean, 7.7 mg/m3) and composting (mean, 4.6 mg/m3). Samples collected on the composting site contained the largest amount of endotoxins (mean concentration, 76 ng/m3). This was followed by sorting facility (61 ng/m3) and waste collection area (36 ng/m3). Gram-negative rods (primarily intestinal) were found in all samples collected at workposts, which justified the adoption of the air concentrations of endotoxins as a criterion for assessing their hygienic conditions. Taking MAC for total suspended dust (4.0 mg/m3) and the concentration of 10 ng/m3 for endotoxin as the criteria for the exposure evaluation, it must be considered that waste collectors and composting site workers are working in poor hygienic conditions. Workers employed at the most hazardous workposts did not use personal protective equipment (glasses, antirespirators), thus infringing a fundamental condition for limiting health hazards (Directive 2000/54/EC).

36/2523

Tytuł oryginału: Remarks on safety assessment, quality assurance, and diagnostic reference levels in medical X-ray imaging.
Autorzy: Golnik Natalia, Ratajczyk-Dziewięcka Małgorzata, Maciejewski Krzysztof
Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.15-22, bibliogr. 10 poz.
Sygnatura GBL: 306,499

Hasła klasyfikacyjne GBL:

radiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The new Polish legislation (Atomic Law) and recent recommendations of international organizations require to pay more attention to control the risk associated with the operation of medical radiation sources. A comprehensive regulatory framework is necessary to ensure that a consistent approach is applied to all elements of the safety system. The paper shortly describes how safety assessment fits into the regulatory process and provides some information on the elements of a safety assessment. Complementary to the safety assessment, a program of quality assurance, QA, should be implemented to periodically check all aparameters which influence the patient dose and the image quality. The last part of the paper concern the implementation of diagnostic reference levels, recommended as a practical tool to mange radiation dose to patients in diagnostic radiology and nuclear medicine.

37/2523

Tytuł oryginału: On the acoustic phenomena produced by turbulence in the flowing blood.
Autorzy: Góral-Wójcicka A., Borgieł W., Małota Z., Nawrat Z.
Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.29-35, il., bibliogr. 12 poz.
Sygnatura GBL: 306,499

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: A turbulent flow can be a source of sounds called "murmur" or "souffle", and can be a result of pathology in the blood vascular system. A model of acoustical effects, related to stenosis of the aorta, was created. Numerical calculations of pressure fluctuations in the environment of a simulated turbulent region were performed.

38/2523

Tytuł oryginału: Dosimetric verification of dose distributions calculated for Co-60 beams with individual compensation filters.
Autorzy: Perczak Aneta, Kukołowicz Paweł, Bulski Wojciech
Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.49-61, il., tab., bibliogr. 12 poz.
Sygnatura GBL: 306,499

Hasła klasyfikacyjne GBL:

radiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The compensating filters used in radiotherapy modify dose distribution in the entire field of the radiation beam, no matter what is the shape of the surface of the body. The determination of the shape of the compensator in a given clinical siluation calls for the use of advanced software tools. Modern treatment planning systems provide necessary modules needed to calculate the shapes of the compensation filters. Reliable use of these systems requires verification of such calculations. In this study, in order to evaluate the accuracy of the calculations, the dose distributions for Co-60 beams modified by the compensators, calculated by the computer system TMS-Helax were verified by comparing them with the measured dose distributions.

39/2523

Tytuł oryginału: The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteins.
Autorzy: Noordzij Jeroen G., Bruin-Versteeg Sandra de, Verkaik Nicole S., Vossen Jaak M. J. J., Groot Ronald de, Bernatowska Ewa, Langerak Anton W., Gent Dik C. van, Dongen Jacques J. M. van
Źródło: Blood 2002: 100 (6) s.2145-2152, il., tab., bibliogr. 45 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The protein products of the recombination activating genes (RAG1 and RAG2) initiate the formation of immunoglobulin (lg) and T-cell receptors, whichare essential for B- and t-cell development, respectively. Mutations in the RAG genes result in severe combined immunodeficiency disease (SCID), generally characterized by the absence of mature B and T lymphocytes, but presence of natural killer (NK) cells. Biochemically, mutations in the RAG genes result either in nonfunctional proteins or in proteins with partial recombination activity. The mutated RAG genes of 9 patients from 7 families were analyzed for their recombination activity using extrachromosomal recombination substrates, rearrangment of endogenous Ig loci in RAG gene-transfected nonlymphoid cells, or the presence of Ig gene rearrangements in bone marrow (BM). Recombination activity was virtually absent in all 6 patients with mutations in the RAG core domains, but partial activity was present in the other 3 RAG-deficient patients, 2 of them having Omenn syndrome with oligocional T lymphocytes. Using 4-color flow cytometry, we could define the exact stage at which B-cell differentiation was arrested in the BM of 5 RAG-deficient SCID patients. In 4 of 5 patients, the absence of recombination activity was associated with a complete B-cell differentiation arrest at the transition from cytoplasmic (Cy) Igć- pre -B-I cells to Cylgć+ pre -B-II cells. However, the fifth patient showed low frequencies of precursor B cells with Cylgć and surface membrane IgM...

40/2523

Tytuł oryginału: Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-B-ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease.
Autorzy: Szczepański Tomasz, Willemse Marja J., Brinkhof Bas, Wering Elisabeth R. van, Burg Mirjam van der, Dongen Jacques J. M. van
Źródło: Blood 2002: 99 (7) s.2315-2323, il., tab., bibliogr. 47 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dzieci 13-18 r.ż.

Streszczenie angielskie: Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements are excellent patient-specific polymerase chain reaction (PCR) targets for detection of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL), but they might be unstable during the disease course. Therefore, we performed detailed molecular studies in 96 childhood precusor-B-ALL at diagnosis and at relapse (n = 91) or at presumably secondary acute myeloid leukemia (n = 5). Clonal Ig and TCR tatgets for MRD detection were identified in 94 patients, with 71 p.c. of these targets being preserved at relapse. The best stability was found for IGK-Kde rearrangements (90 p.c.), followed by TCRG (75 p.c.), IGH (64 p.c.), and incomplete TCRD rearrangements (63 p.c.). Combined Southern blot and PCR data for IGH, IGK-Kde, and TCRD genes showed significant differences in stability at relapse between monoclonal and oligoclonal rearrangements: 89 p.c. versus 40 p.c., respectively. In 38 p.c. of patients all MRD-PCR targets were preserved at relapse, and in 40 p.c. most of the targets (ň 50 p.c.) were preserved. In 22 p.c. of patients most targets (10 cases) or all targets (10 cases) were lost at relapse. The latter 10 cases included 4 patients with secondary acute myeloid leukemia with germiline Ig/TCR genes. In 5 other patients additional analyses proved the clonal relationship between both disease stages. Finally, in 1 patient all Ig/TCR gene rearrangements were completely different between diagnosis and relapse, which is suggestive of secondary ALL...

41/2523

Tytuł oryginału: Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome.
Autorzy: Juszyczyński Przemysław, Kalinka Ewa, Bienvenu Jacques, Woszczek Grzegorz, Borowiec Maciej, Robak Tadeusz, Kowalski Marek, Lech-Maranda Ewa, Baseggio Lucile, Coiffier Bertrand, Salles Gilles, Warzocha Krzysztof
Źródło: Blood 2002: 100 (8) s.3037-3040, il., tab., bibliogr. 23 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:

hematologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: at least 2 inherited factors involved in NHL outcome.

Streszczenie angielskie: Tumor necrosis factor (TNF) production and non-Hodgkin lymphoma (NHL) outcome was found to be related to the TNF-308 polymorphism. To explore whether this could be linked to neighboring polymorphisms, we genotyped the TNF-376,-308,-238,-163, lymphotoxin alpha (LTŕ)+252, and HLA DRB1 alleles in 204 patients with NHL and 120 controls. TNF-308A was the only allele associated with higher TNF and its p55 and p75 receptors' levels (P=.009, P=.03, and P=.007) and lower complete remission rates (P=.006). Freedom from progession (FFP) and overall survival (OS) were shorter in patients with TNF-308A (P=.009 and P=.02), null HLA DRB1*02 allele (P=.007 and P.14) or both genetic markers (P=.004 and P.005). Multivariate analysis incorporating international. Prognostic index (IPI) identified TNF-308A (P .0001, relative risk (RR) = 1.63; P .0001, RR=1.51) and null HLA DRB1*02 alleles (P=.015, RR - 1.18; P .0001, RR = 1.25) as independent factors for FFP and OS. These results indicate the existence of least 2 inherited factors involved in NHL outcome. (Blood. 2002; 100 : 3037-3040).

42/2523

Tytuł oryginału: Modulation of the activity of calcium-activated neutral proteases (calpains) in chronic lymphocytic leukemia (B-CLL) cells.
Autorzy: Witkowski Jacek M., Żmuda-Trzebiatowska Emilia, Świercz Jakub M., Cichorek Mirosława, Ciepluch Hanna, Lewandowski Krzysztof, Bryl Ewa, Hellmann Andrzej
Źródło: Blood 2002: 100 (5) s.1802-1809, il., bibliogr. 57 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Decreased susceptibility to apoptosis and impaired proliferative control are throught to be responsible for prolonged life spain and accumulation of chronic lymphocytic leukaemia (B-CLL) cells. The acitivity of calpains (calcium-dependent, neutral proteases, active in the cells responding to signals inducing a rise of cytoplasmic (Ca++) is involed in the regulation of apoptosis of some cell types by interaction with caspase-3. This work verifies the hypothesis of the abnormal activity of calpains and its role in reduced apoptosis of the BCL cells. Casein zymography, reverse transcriptase-polymerase chain reaction, and Western blotting were used for identification and quantification of the activity and expression of calpains (calcium-dependent, neutral proteases, active in the cells responding to signals inducing a rise of cytoplamic (Ca++) is involved in the regulation of apoptosis of some cell types by interaction with caspase-3. This work verifies the hypothesis of the abnormal activity of calpains and its role in reduced apoptosis of the B-CLL cells. Casein zymography, reverse transcriptase-polymerase chain reaction, and Western blotting were used for identification and quantification of the activity and expression of calpains in B-CLL cells and purified B lymphocytes. The activity and expression of ć-calpain (requiring micromolar Ca++ for activation) are significantly higher in the leukemic than in nonmalignant cells. Conctrarily, the activity and expression of m-calpain (requiring milimolar Ca++) as well as the expression of calpastatin (an endogenous inhibitor of...

43/2523

Tytuł oryginału: Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia.
Autorzy: Hoelzer Dieter, Gkbuget Nicola, Digel Werner, Faak Thomas, Kneba Michael, Reutzel Regina, Romejko-Jarosińska Joanna, Zwoliński Jacek, Walewski Jan
Źródło: Blood 2002: 99 (12) s.4379-4395, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: We treated 45 adult patients with T-lymphoblastic lymphoma (T-LBL) (age range 15-61 years) with 2 protocols designed for adult acute lymphoblastic leukemia (ALL). An encouraging cure rate of 90 p.c. was recently reported for T-LBL in children treated with a similar approach. In our study an 8-drug standard induction was administered over 8 weeks including prophylactic cranial (24 Gy) and mediastinal irradiation(24 Gy) followed by consolidation and reinduction therapy. AT diagnosis, 91 p.c. of the 45 patients showed a mediastinal tumor and 40 p.c. had pleural/pericardial effusions: 73 p.c. of the patients had stage III/IV disease. Ovarall 42 patients (93 p.c.) achieved a complete remission (CR), 2 patients (4 p.c.) achieved a partial remission, and 1 patient (2 p.c.) died during induction. In patients with stage I-III disease (n=18) the CR rate was 100 p.c. compared with 89 p.c. in stage IV (n=27). There were 15 patients who relapsed (36 p.c.) within 12-months. The majority of relapses (47 p.c.) occurred in the mediastinum (n=7) despite mediastinal irradiation with 24 Gy in 6 out of 7 patients. The estimates for overall survival, continuous CR, and disease-free survival at 7 years are 51 p.c., 65 p.c., and 62 p.c., respectively. Stage, age, lactate dehydrogenase and all other parameters had no influence on achievement of CR or outcome. This study demonstrates in a large cohort of patients with adult T-LBL that a high CR rate and a favourable outcome can be achieved with an ALL-type regimen. Mediastinal recurrence was the major obstacle and further improvement...

44/2523

Tytuł oryginału: Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.
Autorzy: Nieborowska-Skorska Małgorzata, Hoser Grażyna, Kossev Plamen, Wasik Mariusz A., Skorski Tomasz
Źródło: Blood 2002: 99 (12) s.4531-4539, il., bibliogr. 68 poz.
Sygnatura GBL: 301,770

Hasła klasyfikacyjne GBL:

hematologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: BCR/ABL oncogenic tyrosine kinase activates STAT5, which plays an important role in leukemogenesis. The downstream effectors of the BCR/ABL- STAT5 pathway remain poorly defined. We show here that expression of the antiapoptic protein A1, a member of the Bcl-2 family, and the serine/threonine kinase pim-1 are enhanced by CRB/ABL. This up-regulation requires activation of STAT5 by the signaling from SH3 + SH2 domains of the BCR/ABL. Enhanced expression of A1 and pim-1 played a key role in the BCR/ABL-mediated cell protection from apoptosis. In addition, pim-1 promoted proliferation of the BCR/ABL-transformed cells. Both A1 and pim-1 were required to induce interleukin 3-independent cell growth, inhibit activation of caspase 3, and stimulate cell cycle progression. Moreover, simultaneous up-regulation of both A1 and pim-1 was essential for in vitro transformation and in vivo leukemogenesis mediated by BCR/ABL. These data indicate that induction of A1 and pim-1 expression may play a critical role in the BCR/ABL - depenendent transformation.

45/2523

Tytuł oryginału: Early detection of COPD by high-risk population spirometric screening.
Autorzy: Zieliński J.
Źródło: Eur. Respir. Rev. 2002: 12 (86/87) s.287-288
Sygnatura GBL: 313,671

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

46/2523

Tytuł oryginału: Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
Autorzy: Johnson Richard J., Herrera-Acosta Jaime, Schreiner George F., Rodriguez-Iturbe Bernardo
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[23-33], il., bibliogr. 94 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

47/2523

Tytuł oryginału: The vascular endothelin system is not overactive in normotensive hemodialysis patients
Autorzy: Bssemaker Eckhart, Passauer Jens, Reimann Doreen, Schulze Beate, Reichel Wolfgang, Gross Peter
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[59-67], il., tab., bibliogr. 30 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

48/2523

Tytuł oryginału: Ageing and heart failure : the place of ACE inhibitors in heart failure with preserved systolic function
Autorzy: Tendera M[ichał]
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[69-75], il., tab., bibliogr. 54 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

49/2523

Tytuł oryginału: Chronic hypokalaemia of adults : Gitelman's syndrome is frequent but classical Bartter's syndrome is rare
Autorzy: Gladziwa U., Schwarz R., Gitter A. H., Bijman J., Seyberth H., Beck F., Ritz E, Gross P[eter]
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[81-87], il., tab., bibliogr. 22 poz., sum. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

50/2523

Tytuł oryginału: Chronic, diagnosis-resistant hypokalaemia
Autorzy: Reimann Doreen, Gross Peter
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[89-93], il., tab., bibliogr. 30 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

51/2523

Tytuł oryginału: Oral antihyperglycemic therapy for type 2 diabetes
Autorzy: Inzucchi Silvio E.
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[127-139], il., tab., bibliogr. 154 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

52/2523

Tytuł oryginału: Insulin therapy in type 2 diabetes
Autorzy: Hollander Priscilla
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[141-146], il., tab., bibliogr. 36 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

53/2523

Tytuł oryginału: Advances in the treatment of renal anaemia
Autorzy: Locatelli Francesco
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[147-160], il. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

54/2523

Tytuł oryginału: HMG-CoA reductase inhibitors are associated with reduced mortality in ESRD patients
Autorzy: Seliger Stephen L., Weiss Noel S., Gillen Daniel L., Kestenbaum Bryan, Ball Adrianne, Sherrard Donald J., Stehman-Breen Catherine O.
Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[171-178], il., tab., bibliogr. 31 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

55/2523

Tytuł oryginału: Atherogenic lipoproteins in end-stage renal disease
Autorzy: Shoji Tetsuo, Ishimura Eiji, Inaba Masaaki, Tabata Tsutomu, Nishizawa Yoshiki
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[179-182], il., bibliogr. 23 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

56/2523

Tytuł oryginału: Tailoring the initial vascular access for dialysis patients
Autorzy: Konner Klaus, Hulbert-Shearon Tempie E., Roys Erik C., Port Friedrich K.
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[235-244], il., tab., bibliogr. 28 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

57/2523

Tytuł oryginału: Peritonitis in peritoneal dialysis
Autorzy: Voinescu C. G., Khanna R.
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[245-260], tab., bibliogr. 94 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

58/2523

Tytuł oryginału: The malnutrition, inflammation, and atherosclerosis (MIA) syndrome : the heart of the matter
Autorzy: Pecoits-Filho Roberto, Lindholm Bengt, Stenvinkel Peter
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[283-286], il., bibliogr. 34 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

59/2523

Tytuł oryginału: Principles and practice of renal transplantation
Autorzy: Kahan Barry D., Ponticelli Claudio
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[303-321], il., tab. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

transplantologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

60/2523

Tytuł oryginału: Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis
Autorzy: Dreke Tilman B.
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[337-339], bibliogr. 23 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

61/2523

Tytuł oryginału: Influence of intensive movement rehabilitation in scout camps on ventilatory parameters of the respiratory tract in children with mild idiopathic scoliosis from highly polluted areas.
Tytuł polski: Wpływ intensywnego usprawniania ruchowego podczas obozu harcerskiego na czynność układu oddechowego u dzieci ze skoliozą idiopatyczną, pochodzących ze środowiska skażonego.
Autorzy: Żaba Ryszard
Źródło: Wiad. Lek. 2002: 55 supl. 1 cz. 2: Konferencja naukowa "Śląskie dni medycyny społecznej i zdrowia publicznego" s.1003-1008, tab., bibliogr. 19 poz., streszcz. - Konferencja naukowa pt. Śląskie dni medycyny społecznej i zdrowia publicznego Zabrze - Szczyrk 2002
Sygnatura GBL: 301,774

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: Przebadano grupę 42 dzieci ze skoliozą idiopatyczną I stopnia wg Cobba (skrzywienie kręgosłupa poniżej 30 stopni) oraz grupę kontrolną 14 zdrowych dzieci biorących uddział w harcerskim obozie zdrowotnym (Obóz I), jak również przebadano grupę 19 dzieci ze skoliozą I stopnia, która po raz drugi uczestniczyła w harcerskim obozie rehabilitacyjnym (Obóz II). U wszystkich badanych dzieci, zarówno przed jak i po pobycie na 4 tygodniowym obozie rehabilitacyjnym oznaczono aparatem Vitalograph następujące wskaźniki wentylacyjne płuc: pojemność życiową płuc - FVC, maksymalną objętość wydechową jednosekundową - FEV1 oraz określono FEV1 proc. FVC. Porównując średnie wartości mierzonych wskaźników spirometrycznych płuc przed i po pobycie na pierwszym Obozie Rehabilitacyjnym, nie wykazano statystycznie znamiennych przyrostów. Równocześnie porównując mierzone wskaźniki wentylacyjne FVC i FEV1 po pobycie na drugim Obozie Rehabilitacyjnym, wykazano statystycznie znamienne ich przyrosty.

Streszczenie angielskie: In 42 children with mild idiopathic scoliosis Iř (spinal curvature less than 30ř) and in the control - 14 healthy children (camp I) as well as in 19 children with idiopathic scoliosis spending time in a camp for the second time (camp II) ventilatory lung parameters: vital capacity - VC, maximal forced expiratory volume one sec. - FEV1 and FEV1 p.c. FVC were determined. Tests were carried out with use of Vitalograph before and after four-week rehabilitation camp. When the mean values of spirometric parameters were compared between the two groups of children (camp I) before and after the camp, statistically significant values were not observed. Simultaneously, in children staying in the camp second time around (camp II), when the mean values of spirometric parameters were correlated between the two camps as well as before and after the second camp, statistically significant increased values of parameters were observed. Leaving Silesia, an area with high air pollution is one of the major tasks of Scout Health Camps for children with idiopathic scoliosis.

62/2523

Tytuł oryginału: Inhibition of alkaline phosphatase activity of boar semen by pentoxifylline, caffeine, and theophylline.
Autorzy: Głogowski Jan, Danforth Douglas R., Ciereszko Andrzej
Źródło: J. Androl. 2002: 23 (6) s.783-792, il., bibliogr. s. 790-792
Sygnatura GBL: 313,131

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: Methyl xanthines have been used frequently as additives to sperm suspensions in order to improve sper characteristics. The mechanism of action on spermatozoa is generally assumed to be inhibition of sperm phospodiesterase activity, resulting in elevation of complementary adenosine monophosphate levels in spermatozoa. The present study was designed to examine the effect of methyl xanthines (pentoxifylline, caffeine, and theophylline) on another important enzyme system, alkaline phosphatase, in boar seminal plasma and spermatozoa. Inhibition of sperm alkaline phosphatase could be distinguished from that of seminal plasma by a paradoxical stimulation by pentoxifylline at lower pH values in spermatozoa. Among the three methyl xanthines, theophylline exhibited the most dramatic inhibition of alkaline phosphatase activity and substrate inhibition was observed with increasing concentrations. Each methyl xanthine had a different action on alkaline phosphatase activity at lower pH; theophylline showed the highest inhibition, caffeine inhibition was not related to pH, and pentoxifylline did not inhibit alkaline phosphatase of seminal plasma and, in fact, it stimulated its activity (or that of a phosphatase with lower pH optimum) in spermatozoa. These results indicate another possible mechanism of action of methyl xanthines on sperm and are in agreement with data indicating that methyl xanthines are not specific inhibitors of sperm phosphodiesterase, because clearly, they inhibit alkaline phosphatase activity as well.

63/2523

Tytuł oryginału: Bacterial infections - an early detection and cellular defense.
Tytuł polski: Zakażenia bakteryjne - wczesna diagnostyka i odporność komórkowa.
Autorzy: Maliński Tadeusz
Źródło: Nowiny Lek. 2002: 71 supl. 1: Zakażenia szpitalne: postępy w diagnostyce, terapii i profilaktyce s.19-20, bibliogr. 6 poz. - 9 Zjazd Polskiego Towarzystwa Zakażeń Szpitalnych pt. Zakażenia szpitalne: postępy w diagnostyce, terapii i profilaktyce Poznań 25-27.09. 2002
Sygnatura GBL: 310,004

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

64/2523

Tytuł oryginału: 8th European Congress of Dentomaxillofacial Radiology : programme and abstracts
Źródło: - [Cracow, b.w. 2002], 96 s., 21 cm. - 8 Europejski Kongres Radiologii Stomatologicznej i Szczękowo-Twarzowej Kraków 06-08.06. 2002
Sygnatura GBL: 735,461

Hasła klasyfikacyjne GBL:

stomatologia

radiologia

Typ dokumentu:

streszczenie

65/2523

Tytuł oryginału: Immunosupression in liver transplantation for hepatic and biliary malignancy : the effect on tumor recurrence
Autorzy: Pączek Leszek, Ołdakowska-Jedynak Urszula
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[23-27] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

transplantologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

66/2523

Tytuł oryginału: Sixteen-year experience with liver transplantation in hepatocarcinoma, and comparison with liver resection
Autorzy: Gonzalez-Pinto Ignacio
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[28-29] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

67/2523

Tytuł oryginału: Indications and results of liver resection and transplantation for HCC
Autorzy: Jonas Sven, Neuhaus Peter
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[30-33] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

68/2523

Tytuł oryginału: Liver resection and transplantation for primary liver tumors
Autorzy: Farges Olivier
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[33-34] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

69/2523

Tytuł oryginału: Liver resection for HCC : IKEM prague experience
Autorzy: Ryska M., Belina F., Langer D.
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[35] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

70/2523

Tytuł oryginału: Liver transplantation in children with hepatic tumors
Autorzy: Kaliciński Piotr
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[36-37] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

71/2523

Tytuł oryginału: Surgical treatment of the patients with HCC : experience of the Department of General and Liver Surgery
Autorzy: Krawczyk Marek
Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[38-44], il., tab. - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
Sygnatura GBL: 735,774

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

72/2523

Tytuł oryginału: DOTS Expansion Plan to Stop TB in the WHO European Region 2002-2006
Opracowanie edytorskie: Danzon Marc (przedm.).
Źródło: - [Cophenhagen, World Health Organization 2002], V, 46 s. : il., tab., 30 cm.
Sygnatura GBL: 291,084

Hasła klasyfikacyjne GBL:

choroby zakaźne

Typ dokumentu:

73/2523

Tytuł oryginału: Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer.
Autorzy: Jereczek-Fossa Barbara A., Jassem Jacek, Badzio Andrzej
Źródło: Int. J. Radiat. Oncol. Biol. Phys. 2002: 52 (2) s.476-482, il., tab., bibliogr. 49 poz.
Sygnatura GBL: 312,578

Hasła klasyfikacyjne GBL:

radiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: Purpose: To evaluate the relationship between acute and late normal tissue reaction in 317 consecutive endometrial cancer patients treated with surgery and adjuvant radiotherapy (RT). Methods: The data of 317 patients (staging according to the International Federation of Gynecology and Obstetrics) treated with postoperative RT were analyzed. Both low-dose-rat brachytherapy and external beam RT were applied in 247 patients (78 p.c.); brachytherapy only in 49 (15 p.c.) and external beam irradiation only in 21 (7 p.c.). The median follow-up was 7.3 years (range 4-21). The European Organization for Research and Treatment of Cancer, Radiation Therapy Oncology Group system with elements of the late effects of normal tissue, sibjective, objective, management, analytic (LENT/SOMA) scale was used to score the RT reactions. The correlation between the occurrence and severity of acute and late bowel and bladder toxicity, as well as the relationship between the severity of acute effects and time to occurrence of late reactions, were assessed using linear and logistic regression analyses. Results: Of the 317 patients, 268 (85 p.c.) experienced acute RT reactions of any grade. Severe acute bowel reactions were observed in 15 patients (5 p.c.), urinary bladder complications in 1 patient (0.5 p.c.) cutaneous in 1 patient (0.5 p.c.), and vaginal in 1 patient (0.5 p.c.). Severe acute hematologic toxicity was seen in 3 patients (1 p.c.). A total of 158 patients (51 p.c.) experienced late RT reactions of any grade. Severe late bowel reactions were obsrved in 19 patients (6 p.c.), urinary bladder in 5 (2 p.c.), vaginal in 3 (1 p.c.), and bone in 10 (4 p.c.)...

74/2523

Tytuł oryginału: Detection of enterotoxigenic Clostridium perfringens with a duplex PCR.
Autorzy: Augustynowicz E[wa], Gzyl A., Ślusarczyk J.
Źródło: J. Med. Microbiol. 2002: 51 (2) s.169-172, il., tab., bibliogr. 24 poz.
Sygnatura GBL: 305,350

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: Two sets of primers sedigned to detect Clostridium perfringens phospholipase C (plc) and enterotoxin (cpe) genes in a single PCR reaction were applied to a collection of 64 predominantly food poisoning-related C. perfringens isolates. In-vitro enterotoxin synthesis was tested serologically after inducing sporulation. Of the 64 isolates, 26 were clearly enterotoxigenic: 16 were classified as potentially enterotoxigenic only as serological testing did not confirm enterotoxin production, Duplex PCR for diagnosis of enteroxigenic C. perfringens from vegetative cultures can be a useful tool as fresh isolates often sporulate poorly or not all, giving rise to the possibility of false negative results by serological analysis.

75/2523

Tytuł oryginału: Free radicals-mediated induction of oxidized DNA bases and DNA-protein cross-links by nickel chloride.
Autorzy: Woźniak Katarzyna, Błasiak Janusz
Źródło: Mutat. Res 2002: 514 (1/2) s.233-243, il., tab., bibliogr. 50 poz.
Sygnatura GBL: 304,952

Hasła klasyfikacyjne GBL:

genetyka

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Using the comet assay, we showed that nickel chloride at 250-1000 ćM induced DNA damage in human lymphocytes, measured as the change in comet tail moment, which increased with concentration up to 500 ćM and then decreased. Observed increase might follow from the induction of strand breaks or/and alkali-labile sites (ALS) by nickel, whereas decrease from its induction of DNA-DNA and/or DNA-protein cross-links. Proteinase K caused an increase in the tail moment, suggesting that nickel chloride at 1000 ćM might cross-link DNA with nuclear proteins. Lymphocytes exposed to NiCl2 and treated with enzymes recognizing oxidized and alkylate bases: endonuclease III (Endo III), formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (AlkA), dusplayed greated extent of DNA damege than those not treated with these enzymes, indicating the induction of oxidized and alkylated bases by nickel. The incubation of lymphocytes with spin traps, 5,5-dimethyl-pyrroline N-oxide (DMPO) and PBN decreased the extent of DNA damage which might follow from the production of free radicals by nickel. The pre-treatment with Vitamin C at 10 ćM and Vitamin E at 25 ćM decreased the tail moment of the cells exposed to CiCl2 at the concentrations of the metal causing strand breaks or/and ALS. The results obtained suggest that free radicals may be involved in the formation of strand breaks or/and ALS in DNA as well as DNA-protein cross-links induced by NiCl2. Nickel chloride can also alkulate DNA bases. Our results support thesis on multiple, free radicals-based genotoxicity pathways of nickel.

76/2523

Tytuł oryginału: Comparative studies of osteoblast and fibroblast type I collagen in a patient with osteogenesis imperfecta type IV.
Autorzy: Galicka Anna, Wołczyński Sławomir, Gińdzieński Andrzej
Źródło: J. Pathol. 2002: 196 (2) s.235-237, il., bibliogr. 16 poz.
Sygnatura GBL: 302,048

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

in vitro

Streszczenie angielskie: The expression of type I collagen has been compared in fibroblast and osteoblast cultures of a patient with moderately severe osteogenesis imperfecta (OI) type IV, with respect to control cells. Electrophoretic analysis of type I collagen showed that both OI osteoblasts and fibroblasts synthesized normal chains with delayed migration. However, the osteoblasts contained a higher proportion of abnormal chains than fibroblasts from the proband. Pulse-chase experiments showed that the trimers containing abnormal chains were cleared more rapidly from osteoblasts than fibroblasts. Moreover, the collagen secreted by OI osteoblests had thermal stability 1řC higher than collagen secreted by OI fibroblasts. These results suggest that the abnormal collagen in osteoblasts may be more resistant to intra- and extracellular degradation and my thus have better survival than in fibroblasts. This finding could have implications for understanding the clinical phenotype of OI.

77/2523

Tytuł oryginału: Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice.
Autorzy: Giermasz Adam, Makowski Marcin, Kozłowska Ewa, Nowis Dominika, Maj Małgorzata, Jalili Ahmad, Feleszko Wojciech, Wójcik Cezary, Dąbrowska Anna, Jakóbisiak Marek, Gołąb Jakub
Źródło: Int. J. Cancer 2002: 97 (6) s.746-750, il., bibliogr. 32 poz.
Sygnatura GBL: 305,029

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Lovastatin, the drug used for the treatment of hypercholesterolemia, has previously been reported to exert antitumor activity in experimental murine models. Byturate and butyric acid derivatives are well known to induce differentiation and apoptosis of tumour cells and also have recently gained acceptance as potentaial anticancer agents. In this study, we examined the antitumor effects of the combination of lovastatin and butyrate or its prodrug tributyrin in vitro and in vivo against a murine Lewis lung carcinoma (3LL). This combination therapy showed synergistic antitumor activity against 3LL cells in vitro. These effects were at least in part due to apoptosis induction that occurred after 12 hr of incubation with lovastatin and butyrate and was preceded by changes in cell cycle distribution of treated cells and expression of p21, p53 and cyclin D 1. Remarkably, a systemic treatment of syngeneic mice inoculated with 3LL cells with both drugs resulted in significant tumour growth retardation.

78/2523

Tytuł oryginału: Accuracy of transcranial color Doppler ultrasonography in the diagnosis of middle cerebral artery spasm determined by receiver operating characteristic analysis.
Autorzy: Mariak Zenon, Krejza Jarosław, Świercz Mirosław, Kordecki Kazimierz, Lewko Janusz
Źródło: J. Neurosurg. 2002: 96 (2) s.323-330, il., tab., bibliogr. 68 poz.
Sygnatura GBL: 301,435

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Object. The value of transcranial Doppler ultrasonography for the detection of middle cerebral artery (MCA) spasm has been asserted. None of the published studies, however, has adequately scrutinized the overall diagnostic accuracy of this procedure. There are only sporadic reports concerning the utility of transcranial color Doppler (TCCD) ultrasonography, although this method has been proved to be more precise. In this study the authors attempted to estimate the performance of TCD ultrasonography in detecting MCA narrowing by using receiver operating characteristic (ROC) curve analysis, based on TCCD studies obtained in a relatively large, randomly selected population of patients. Methods. Transcranial color Doppler ultrasonography studies were obtained in 100 consecutive patients (54 men and 46 women ages 18-74 years, median age 50 years) routinely referred by neurosurgeons for intraarterial angiography. The M1 segment of the MCA was insonated using a 2.5-MHz probe via a temporal acoustic window, and angle-corrected flow velocities were obtained. Angiographically depicted vasospasm was graded as none, mild (ó 25 p.c. vessel caliber reduction), and moderate to severe ( 25 p.c. vessel caliber reduction). The effectiveness of TCCD ultrasonography in diagnosing MCA spasm was evaluated by calculating the areas under the ROC curves (Az). Of the 200 MCAs examined, 173 were successfully visualized with the aid of TCCD ultrasonography. Mild vasospasm was angiographically diagnosed in 15 arteries and moderate-to-severe vasospasm in 28...

79/2523

Tytuł oryginału: Expression of FasL gene in T cells of renal allograft recipients.
Autorzy: Kasprzycka Monika, Kłodos Konrad, Nowaczyk Maria, Wyzgał Janusz, Podobińska Iwona, Durlik Magdalena, Górski Andrzej
Źródło: Immunol. Lett. 2002: 80 (1) s.9-13, il., tab., bibliogr. 17 poz.
Sygnatura GBL: 312,663

Hasła klasyfikacyjne GBL:

nefrologia

transplantologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: FasL molecule expressed on activated T cells induces apoptosis in Fas-expressing cells. It is possible that apoptosis induced by FasL is involved in the process of allograft destruction brought about by infiltrating T cells. The aim of our study was to evaluate expression of FasL gene in peripheral blood T cells of renal allograft recipients (RAR). We have studied 25 patients: 16 with uneventful stable course (RAR-S) and nine during biopsy proven chronic rejection (RAR-CH). The relative expression of FasL mRNA compared with that of á-actin was established by semi-quantitive RT-PCR. We have found that FasL gene expression was significantly increased in T cells of RAR-CH compared to RAR-S (P 0.01). Our results suggest that T cells expression of FasL gene is increased during chronic rejection. Therefore, this phenomenon may pay a role in allograft injury associated with that process. Further studies are needed to unravel possible clinical consequences of observed differences in T cell expression of FasL.

80/2523

Tytuł oryginału: Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women.
Autorzy: Rachoń D., Myśliwska J., Suchecka-Rachoń K., Więckiewicz J.
Źródło: J. Endocrinol. 2002: 172 (2) s.387-395, il., tab., bibliogr. s. 393-395
Sygnatura GBL: 310,833

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Various hormones can influence the expression of interleukin-6 (IL-6) and oestrogens are the most extensively studied. There is, however, controversy about the nature of the IL-6 secreted by human cells and its regulation by 17á-oestradiol. The aim of this work was to clarify whether oestrogen deprivation after menopause may contribute to an enhanced IL-6 production by peripheral blood mononuclear cells (PBMC) in postmenopausal women. Twenty-two healthy postmenopausal women, age range 45-63 years with clinical symptoms of oestrogen deficiency were enrolled in the study. The control group consisted of 16 healthy young women, age range 22-31 years, with regular menses and who were not taking oral contraceptives. Levels of IL-6 in the sera and PBMC culture supernatants were measured by the biological B9 cell-proliferation assay and expression of the IL-6 gene in non-stiulated PBMC was detected by RT-PCR. The effect of 17á-oestradiol on spontaneous IL-6 production by the PBMC of postmenopausal women was also studied in vitro and in vivo. Seventeen out of the twenty-two postmenopausal women were given hormonal replacement therapy of 50 ćg 17á-oestradiol/day transdermally and the spontaneous production of IL-6 by the PBMC was analysed after 6 and 12 months of treatment. The postmenopausal women had significantly higher serum levels of IL-6 than the young controls. The spontaneous production of IL-6 by non-stimulated PBMC into the culture supernatants was also significantly higher in the postmenopausal women compared with the young...

81/2523

Tytuł oryginału: Myocardial perfusion correlates with improvement of systolic function of the left ventricle after CABG. Dobutamine echocardiography and Tc-99m-MIBI SPECT study.
Autorzy: Paluszkiewicz L., Kwinecki P., Jemielity M., Dyszkiewicz W[ojciech], Cieśliński A., Szyszko A.
Źródło: Eur. J. Cardiothorac. Surg. 2002: 21 (1) s.32-35, tab., bibliogr. 20 poz. - 14 Doroczne Spotkanie Europejskiego Towarzystwa Chirurgii Klatki Piersiowej i Serca Frankfurt 07-11.10. 2000
Sygnatura GBL: 312,899

Hasła klasyfikacyjne GBL:

radiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Objective: The aim of the study was to assess the effect of surgical revascularization [coronary artery bypass grafting (CABG)] on systolic function and perfusion of the left ventricle using dobutamine echocardiography (DE) and Tc-99m-MIBI SPECT (SPECT). Methods: There were 32 patients mean age 52.2 ń 7.2 years in whom DE and SPECT were performed before and 3-4 months after CABG using standard protocols. Wall motion score index (WMSI) and perfusion index (PI) were calculated. Results: Significant improvement of WMSI at rest (1.44 ń 0.46 vs 1.33 ń 0.41; P = 0.03) as well as after maximal dose of dobutamine (1.49 ń 0.42 vs 1.30 ń 0.44; P = 0.02) was observed after CABG as compared to preoparative examination. Similar relation was observed during SPECT study. Perfusion index diminished significantly after revascularization during rest acquisition (2.19 ń 0.71 vs 1.93 ń 0.70; P = 0.0008) and after Dipirydamole administration (2.73 ń 0.73 vs 2.20 ń 0.69; P = 0.0001) as compared to preoperative examination. We found correlation between PI and WMSI at rest before CABG (R = 0.46; P = 0.01). PI after Dipirydamole and WMSI after maximal dose of Dobutamine before CABG (R = 0.37; P = 0.04), PI and WMSI at rest CABG (R = 0.39; P = 0.03), PI after Dipirydamole and WMSI after dobutamine after CABG (R = 0.38; P = 0.03). Conclusions: Surgical revascularization significantly improves both perfusion and contractility. Increased perfusion after CABG correlates with improvement of systolic function of the left ventricle.

82/2523

Tytuł oryginału: A new type of mixed anhydride and its applications to the synthesis of 7-substituted 8-chloro-5,5-dioxoimidazo[1,2-b][1,4,2]benzodithiazines with in vitro antitumor activity.
Autorzy: Brzozowski Zdzisław, Sączewski Franciszek
Źródło: J. Med. Chem. 2002: 45 (2) s.430-437, il., tab., bibliogr. 39 poz.
Sygnatura GBL: 312,133

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: A new series of 8-chloro-5,5-dioximidazo[1,2-b][1,4,2]benzodithiazine derivatives 8-25 with heteroaryloxycarbonyl or heteroarylcarbamoyl substituents at position 7 have been synthesized as potential antitumor agents. In this procedure a novel type of mixed anhydride 7 was prepared from 8-chloro-5,5-dioxoimidazo[1,2-b][1,4,2]benzodithiazine-7-carboxylic acid 6 and methanesulfonyl chloride, which in turn was condensed either with heteroarylamines or heteroarylhydroxy compounds. All the compounds prepared were screened at the National Cancer Institute (NCI) for their activities against a panel of 60 tumor cell lines, and relationships between structure and antitumor activity in vitro are discussed. The amides 8, 10, 12, 13, 21, and ester 25 were inactive, whereas the other compounds exhibited rather moderate activity against one or more human tumor cell lines. The prominent compound with remarkable activity (log GI50 -8) and selectivity for the leukemia HL-60(TB) cell line was 2-methyl-8quinolyl 8-chloro-5,5-dioximidazo[1,2-b][1,4,2]benzodithiazine-7-carboxylate 24.

83/2523

Tytuł oryginału: Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups.
Autorzy: Gasowski Jerzy, Fagard Robert H., Staessen Jan A., Grodzicki Tomasz, Pocock Stuart, Boutitie Florent, Gueyffier Francois, Boissel Jean-Pierre
Źródło: J. Hypertens. 2002: 20 (1) s.145-151, il., tab., bibliogr. 34 poz.
Sygnatura GBL: 313,132

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Objective. Although cirrent guidelines rest exclusively on the measurement of systolic and diastolic blood pressures, the arterial pressure wave is more precisely described as consisting of a pulsatile (pulse pressure) and a steady (mean pressure) component. This study explored the independent roles of pulse pressure and mean pressure as predictors of mortality in a wide range of patients with hypertension. Design and methods. This meta-analysis, based on individual patient data, has combined results from the control groups of seven randomized clinical trials conducted in patients with systolo-diastolic or isolated systolic hypertension. The relative hazard rates associated with pulse pressure and mean pressure were calculated using Cox's proportional hazard regression models with stratification for the seven trials and with adjustment for sex, age, smoking and the other pressure. Results. A 10 mmHg wider pulse pressure at baseline, which corresponds to approximately one-half of its standard deviation, was independently associated with an increase in risk by 6 p.c. for total mortality (P = 0.001), 7 p.c. for cardiovascular mortality (P = 0.01), and 7 p.c. for fatal coronary accidents (P = 0.03). The corresponding increase in risk of fatal stroke was similar (+ 6 p.c., P = 0.27) but there were too few strokes to reach statistical significance. In similar analyses, mean pressure was not identified as an independent predictor of these outcomes. Significant interactions of pulse pressure or mean pressure with age suggested that the prognostic power of pulse pressuer for fatal stroke was more important at higher age (P = 0.04), whereas the prognostic power of mean pressure for coronary mortality was greatest in the young (P = 0.01)...

84/2523

Tytuł oryginału: Inhibition of N-methyl-D-aspartic acid-nitric oxide synthase in rat hippocampal slices by ethanol. Evidence for the involvement of tetrahydrobiopterin but not lipid peroxidation.
Autorzy: Czapski Grzegorz A., Sun Grace Y., Strosznajder Joanna B.
Źródło: J. Biomed. Sci. 2002: 9 (1) s.3-9, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 313,488

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: The ionotropic glutamatergic receptor system, especially the subtype mediated by N-methyl-D-aspartic acid (NMDA), is known to exhibit special sensitivity to the effect of ethanol. This is due partly to the ability of ethanol to modulate the production of nitric oxide through the NMDA-nitric oxide synthase (NOS) pathway. In this study, we examined the effects of ethanol on basal and NMDA-stimulated NOS activity in rat hippocampal slices by measuring the conversion of [**14C]-arginine into [**14C]-citrulline in an incubation system containing the necessary cofactors. Stimulation of hippocampal slices with NMDA (100 ćM) enhanced NOS activity by 43 p.c. (n = 12). Although ethanol did not alter NOS activity when added to the incubation system during NMDA stimulation, it dose-dependently inhibited NMDA-NOS activity when added to the slices during the 90-min preincubation period. Further assay of NOS activity with brain cytosolic fraction indicated an inhibitory effect of ethanol (200 mM) when the assay was carried out in the absence of exogenous tetrahydrobiopterin (BH4), a redox-active cofactor for NOS. Incubation of brain homogenates resulted in a time-dependent increase in the levels of lipid peroxidation products, but ethanol did not further enhance these products. Taken together, these results providence evidence for the role of BH4 but not oxidative stress in the inhibitory effect of ethanol on NMDA-NOS activity in rat hippocampal slices.

85/2523

Tytuł oryginału: Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and Leishmaniasis.
Autorzy: Zhang Peng, Nicholson Diarmuid E., Bujnicki Janusz M., Su Xinzhuan, Brendle James J., Ferdig Michael, Kyle Dennis E., Milhous Wilbur K., Chiang Peter K.
Źródło: J. Biomed. Sci. 2002: 9 (1) s.34-40, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 313,488

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Methionine aminopeptidase 2(MetAP2) is responsible for the hydrolysis of the initiator methionine molecule from the majority of newly synthesized proteins. We have cloned the MetAP2 gene from the malaria parasite Plasmodium falciparum (PfMetAP2; GenBank accession number AF348320). The cloned PfMetAP2 has no intron, consists of 1,544 bp and encodes a protein of 354 amino acids with a molecular mass of 40,537 D and an overall base composition of 72.54 p.c. A + T. PfMetAP2 has 40 p.c. sequence identity with human MetAP2 and 45 p.c. identity with yeast MetAP2, and is located in chromosome 14 of P. falciparum. The three-dimensional structure of PfMetAP2 has been modeled based on the crystal structure of human MetAP2, and several amino acid side chains protruding into the binding pocket that differ between the plasmodial and human enzyme have been identified. The specific MetAP2 inhibitors, fumagilin and TNP-470, potently blocked in vitro growth of P. falciparum and Leishmania donovani, with IC50 values similar to the prototype drugs. Furthermore, in the case of P. falciparum, the chloroquine-resistant strains are equally susceptible to these two compounds.

86/2523

Tytuł oryginału: Intrapartum cardiotocography and fetal pulse oximetry in assessing fetal hypoxia.
Autorzy: Leszczyńska-Gorzelak B., Poniedziałek-Czajkowska E., Oleszczuk J.
Źródło: Int. J. Gynecol. Obstet. 2002: 76 (1) s.9-14, tab., bibliogr. 20 poz.
Sygnatura GBL: 312,925

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płód

ciąża

Streszczenie angielskie: Objectives: A retrospective analysis of short-term variability (STV), a cardiotocography (CTG) parameter, in relation to fetal blood saturation values (FSpO2) obtained by fetal pulse oximetry. Methods: The study included 26 healthy pregnant women monitored continuously during delivery with both cardiotocography and fetal pulse oximetry. Results: Lower FSpO2 values were observed in the group showing STV levels ó 6.0 ms in the 1st stage of labor (44.7 ń 3.46 p.c. vs. 49.2 ń 1.8 p.c.), but this result was not statistically significant. In the 2nd stage of labor, FSpO2 values in the group with STV levels ó 6.0 ms were significantly lower than those with STV levels 6.0 ms (34.4 ń 2.9 p.c. vs. 43 ń 7.2 p.c.; P 0.001). A positive correlation was found between STV levels ó 6.0 ms and mean FSpO2 values in the 2nd stage of labor. Conclusions: 1. A significant relationship was observed between short-term variability in the cardiotocographic records and fetal blood saturation levels in the 2nd stage of labor. 2. Fetal pulse oximetry can be valuable in assessing fetal wellbeing, especially when CTG records are abnormal.

87/2523

Tytuł oryginału: Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodelling.
Autorzy: Jerzak Małgorzata, Bischof Paul
Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 100 (2) s.138-142, il., bibliogr. 56 poz.
Sygnatura GBL: 305,582

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ciąża

Streszczenie angielskie: Apoptosis has been proposed as a mechanism maintaining immune privilege. Expression of Fas ligand (FasL) by the human trophoblast has been recently accepted as a mechanism providing protection against the lytic action of activated decidual immune cells expressing Fas receptor (FasR). Therefore, the purpose of this review was determine the role of apoptosis in early pregnancy maintenance according to the latest literature. We used Medline literature search. The data suggest that apoptosis may serve as a previously unsuspected mechanism that induces tolerance of the foetal allograft against maternal immune system. Apoptosis of activated maternal immune cells occurs in the human decidua mainly through Fas-FasL or receptor for TNF-related apoptosis-inducing ligand (TRAIL-R)-TNF-related apoptosis-inducing ligand (TRAIL) signalling. This might be a defence mechanism against rejection of the foetal allograft by the maternal immune system. In addition, in this review contribution of programmed cell death to placental cell turnover and remodelling during first trimester of pregnancy is also discussed.

88/2523

Tytuł oryginału: Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of low molecular weight heparin. Gynecological ward retrospective analysis.
Autorzy: Cyrkowicz Andrzej
Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 100 (2) s.223-226, tab., bibliogr. 20 poz.
Sygnatura GBL: 305,582

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Objectives: To compare the frequency of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing gynecological operations without low molecular weight heparin (LMWH) prophylaxis and those receiving such prophylaxis. Design: Retrospective, hospital record-based study. Material and methods: About 1785 consecutive patients without LMWH prophylaxis and 1871 ones treated with nadroparin (Fraxiparine) 7500 ICU s.c. 2 h before the operation and repeated daily for 5-7 days or until the patient was fully mobile. DVT was diagnosed on the basis of clinical symptoms and ultrasound examination, and PE clinical symptoms, gasometric data, electrocardiography and chest X-ray. Results: Among the patients without prophylaxis, four cases of PE occurred (0.22 p.c.), two fatal (0.11 p.c.), 13 cases of proximal DVT (0.72 p.c.) and 41 distal DVT complications (2.3 p.c.). In LMWH, group 3 proximal DVT (0.16 p.c.) and 18 distal DVT (0.96 p.c.) developed but there were no clinically expressed pulmonary embolism. According to the Fisher's exact test, the difference between the complications in the analyzed groups is significant P 0.05. Conclusions: The perioperative applying of LMWH to prevent DVT in the patients operated on gynecologically is effective.

89/2523

Tytuł oryginału: Immunopharmacological potential of selective phosphodiesterase inhibition.[P.] 1: Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-ŕ) biosynthesis in alveolar epithelial cells.
Autorzy: Haddad John J., Land Stephen C., Tarnow-Mordi William O., Zembala Marek, Kowalczyk Danuta, Lauterbach Ryszard
Źródło: J. Pharmacol. Exp. Ther. 2002: 300 (2) s.559-566, il., bibliogr. s. 565-566
Sygnatura GBL: 310,547

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: In an attempt to elaborate in vitro on a therapeutic strategy that countracts an inflammatory signal, we previously reported a novel immunopharmacological potential of glutathione, an antioxidant thiol, in regulating inflammatory cytokines. In the present study, we investigated the hypothesis that selective regulation of phosphodiesterases (PDEs), a family of enzymes that controls intracellular cAMP/cGMP degradation, differentially regulates proinflammatory cytokines. Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) blockaded lipopolysaccharide-endotoxin (LPS)-mediated biosynthesis of interleukin (IL)-6, but this pathway had no inhibitory effect on tumor necrosis factor-ŕ (TNF-ŕ). Furthermore, inhibition of PDE3 (amrinone) abolished the effect of LPS on IL-6, but attenuated TNF-ŕ production. Reversible competitive inhibition of PDE4 (rolipram) exhibited a potent inhibitory effect on IL-6 and a dual, biphasic (excitatory/inhibitory) effect on TNF-ŕ secretion. Blockading PDE5 (4-[3',4'-(methylenediox)benzyl]amino-6-methoxyquinazoline) showed a high potency in reducing IL-6 production, but in a manner similar to the inhibition of PDE4, exhibited a biphasic effect on TNF-ŕ biosynthesis. Simultaneous inhibition of PDE5, 6 and 9 (zaprinast), purported to specifically elevate intracellular cGMP, reduced, in a doseindependent manner, IL-6 and TNF-ŕ biosynthesis. Finally, nonselective inhibition of PDE by pentoxyfylline suppressed LPS-mediated secretion of IL-6 and TNF-ŕ. The involvement of specific PDE isoenzymes in differentially regulating LPS-mediated inflammatory cytokine biosynthesis indicates a novel approach to unravel the potential therapeutic targets that these isozymes constitute during the progression of inflammation within the respiratory epithelium.

90/2523

Tytuł oryginału: Immunopharmacological potential of selective phosphodiesterase inhibition. [P.] 2: Evidence for the involvement of an inhibitory-kB/nuclear factor-kB-sensitive pathway in alveolar epithelial cells.
Autorzy: Haddad John J., Land Stephen C., Tarnow-Mordi William O., Zembala Marek, Kowalczyk Danuta, Lauterbach Ryszard
Źródło: J. Pharmacol. Exp. Ther. 2002: 300 (2) s.567-576, il., tab., bibliogr. s. 575-576
Sygnatura GBL: 310,547

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: In this report we investigated the immunopharmacological role of selective and nonselective phosphodiesterase (PDE) inhibition in regulating the inhibitory-kB (IkB-ŕ)/nuclear factor-kB (NF-kB) signally transduction pathway. In fetal alveolar type II epithelial cells, PDE blockade at the level of the diverging cAMP/cGMP pathways differentially regulated the phosphorylation and degradation of IkB-ŕ, the major cytosolic inhibitor of NF-kB. Whereas selective inhibition of PDEs 1, 3, and 4, by the action of 8-methoxymethyl-3-isobutyl-1-methylxanthine, amrinone, and rolipram, respectively, exhibited a tendency to augment the translocation of NF-kB1 (p50), RelA (p65), RelB (p68), and c-Rel (p75), selective blockade of PDE 5, 6, and 9, by the action of 4-[3',4'=(methylenedioxy)benzyl]amino)-6-methoxyquinazoline and zaprinast, attenuated lipopolysaccharide-endotoxin (LPS)-mediated NF-kB translocation. Pentoxifilline, a nonspecific PDE inhibitor, reversed the excitatory effect of LPS on NF-kB subunit nuclear localization, in a dosedependent manner. Furthermore, analysis of NF-kB activation under the same conditions revealed a biphasic effect mediated by LPS. PDEs 1, 3, and 4 inhibition was associated with upregulating NF-kB transcriptional activity. In contrast, blockading the activity of PDEs 5, 6, and 9 negatively attenuated LPS-mediated NF-kB activation, similar to the effect of 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione (pentoxifulline). These results indicate that selective and nonselective interference with the control of the dynamic equilibrium of cyclic nucleotides via PDE isoenzyme regulation represents an immunoregulatory mechanism that requires the differential, biphasic targeting of the IkB-ŕ/NF-kB pathway.

91/2523

Tytuł oryginału: Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis.
Autorzy: Szamatowicz J., Laudański P., Tomaszewska I.
Źródło: Hum. Reprod. 2002: 17 (2) s.284-288, il., tab., bibliogr. s. 287-288
Sygnatura GBL: 313,265

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli 19-44 r.ż.

Streszczenie angielskie: Background: Matrix metalloproteinases (MMPs) are a family of endopeptidases which play a role in the degradation and turnover of extracellular matrix proteins. Their action is regulated by specific tissue inhibitors called tissue inhibitors of metalloproteinases (TIMPs). Methods: We measured the concentrations of total and active MMP-9 in peritoneal fluid of infertile women with mild or moderate endometriosis (n = 22) and compared them with those in a control group of infertile patients (n = 21). Results: We found that the mean (ń SD) total concentrations of MMP-9 in the peritoneal fluid of patients with endometriosis was 6.2 ń 1.8 ng/ml, in comparison with 2.9 ń 2.6 ng/ml in the control group (P = 0.001). Concenrations of active MMP-9 did not differ significantly between the groups. The concentrations of TIMP-1, after logarithmic transformation, were significantly lower (P = 0.017) in endometriotic peritoneal fluids than in peritoneal fluid of control women, 1.02 ń 0.21 ng/ml and 1.16 ń 0.18 ng/ml respectively. No correlation between stage of disease, steroid hormone concentration, MMP-9 (total and active) and TIMP-1 was found. Conclusions: These results suggest that a disturbed equilibrium exists between MMP-9 and TIMP-1 in peritoneal fluid of women with endometriosis. This may play an important role in the pathogenesis of the disease.

92/2523

Tytuł oryginału: HA 1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Caý+ -mediated apoptosis through a protein kinase A-independent mechanism.
Autorzy: Matuszyk Janusz, Cebrat Małgorzata, Kalas Wojciech, Strzadała Leon
Źródło: Int. Immunopharmacol. 2002: 2 (4) s.435-442, il., bibliogr. 20 poz.
Sygnatura GBL: 313,577

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: Our revious reports showed that thymic lymphomas arising in TCR transgenic mice are resistant to Caý+ -mediated apoptosis. Here we show that induction of apoptosis in thymic lymphomas involves a process that is cAMP-mediated and which depends on the activation of protein kinase A (PKA) despite the lower level of PKA type I in these lymphomas compared to thymocytes. Further, we show that treatment of the lymphomas with HA1004, a serine/threonine protein kinase inhibitor, restores their susceptibility to ionomycin-induced apoptosis. Results indicate that HA1004-induced restoration of sensitivity to ionomycin proceeds through a PKA-independent mechanism. Moreover, activation of PKA instead of its inhibition induces apoptosis of lymphoma cells.

93/2523

Tytuł oryginału: Lactoferrin immunomodulation of DTH response in mice.
Autorzy: Actor Jeffrey K., Hwang Shen-An, Olsen Margaret, Zimecki Michał, Hunter jr Robert L., Kruzel Marian L.
Źródło: Int. Immunopharmacol. 2002: 2 (4) s.475-486, il., tab., bibliogr. 51 poz.
Sygnatura GBL: 313,577

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: Improved nontoxic adjuvants, especially adjuvants capable of inducing cell-mediated immunity (CMI), are needed for research in immunology and for development of human and veterinary vaccines. Bovine Lactoferrin, an effector molecule shown to directly participate in host defense, was assessed at various concentrations as an adjuvant component for induction of DTH responses to sheep red blood cells (SRBC). Subcutaneous immunization with Lactoferrin enhanced delayed type hypersensitivity (DTH) in CBA mice in a dose-dependent fashion; DTH responses were most significantly increased when sensitization was accomplished using Lactoferrin at 50 ćg/dose and 250 ćg/dose. Furthermore, Lactoferrin admixed with suboptimal dose of SRBC enhanced DTH responses by over 17-fold. Peritoneal cells collected from mice intraperitoneally injected with a 100 ćg/dose of Lactoferrin demonstrated modest, but significant, production of TNF-ŕ, IL-12 and MIP-1ŕ, when cultured in vitro, compared to saline-injected controls. J774A.1 murine macrophages stimulated with Lactoferrin resulted in increased TNF-ŕ protein production, and upregulated IL-12 and IL-15 mRNA. Levels of message for chemokins MIP-1ŕ and MIP-2 were also increased in a dose-dependent way. Taken together, these results indicate that Lactoferrin as an adjuvant may stimulate macrophages to generate a local environment likely to push immune responses towards development and maintenance of CMI.

94/2523

Tytuł oryginału: Nitric oxide and convulsions in 4-aminopyridine-treated mice.
Autorzy: Tutka Piotr, Młynarczyk Małgorzata, Żółkowska Dorota, Kleinrok Zdzisław, Wielosz Marian, Czuczwar Stanisław J.
Źródło: Eur. J. Pharmacol. 2002: 437 (1/2) s.47-53, il., tab., bibliogr. s. 52-53
Sygnatura GBL: 312,088

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: We studied whether N**G-nitro-L-arginine (NNA), an inhibitor of nitric oxide (NO) synthase as well as L-arginine and molsidomine, two agents elevating NO, influenced convulsions caused by 4-aminopyridine, a K+ channel blocker in mice. NNA, in a dose known to decrease level of NO (40 mg kg -**1), enhanced the susceptibility to intraperitoneal (i.p.) and intracerebroventricular (i,c,v,) 4-aminopyride. L-arginine (500 mg kg -**1) and molsidomine (20 mg kg -**1) alone did not influence 4-aminopyridine-induced seizure activity. Surprisingly, the proconvulsant effect of NNA upon clonic and tonic seizures was potentiated by molsidomine (20 mg kg -**1). No influence of L-arginine on the proconvulsant effect of NNA was found. Taking into account the proconvulsant effect of NNA, an involvement of NO-mediated events in the mechanism of convulsive activity of 4-aminopyridine might by postulated, However, the ineffectiveness of L-arginine and molsidomine to suppress the convulsive activity of 4-aminopyridine as well as a paradoxical potentiation of the proconvulsant effect of NNA by molsidomine seem to exclude the impact of NO pathway on 4-aminopyridine-induced convulsions in mice. Our data suggest that the proconvulsant effect of NNA in this seizure model is caused by other, not related to NO, mechanisms.

95/2523

Tytuł oryginału: Decortication in chronic pleural empyema - effect on lung function.
Autorzy: Rzyman Witold, Skokowski Jan, Romanowicz Grzegorz, Lass Piotr, Dziadziuszko Rafał
Źródło: Eur. J. Cardiothorac. Surg. 2002: 21 (3) s.502-507, il., bibliogr. 24 poz.
Sygnatura GBL: 312,899

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Objective: The aim of the present study is to evaluate the lung function before and after the lung decortication in patients with chronic pleural empyema (CPE).Methods: Twenty-six patients with diagnosis of CPE were evaluated in a prospective manner by lung perfusion scintigraphy, blood gas analysis and spirometry before and 35 weeks (ń 17) after the lung decortication. Results: Preoperative scintigraphy showed reduction of lung perfusion on the affected side to 24.5 p.c. (ń 12.6 p.c.) in 11 right side empyemas (predicted value 55 p.c.) and to 18 p.c. (ń 8 p.c.) in 15 left side empyemas (predicted value 45 p.c.). The postoperative measurements showed improvement in perfusion to 45.2 p.c. (ń 7.7 p.c.) in patients with right side empyema and 34.1 p.c. (ń 8.5 p.c.) with the left side affection. The preoperative vital capacity (VC) was reduced to 62.3 p.c. (ń 13.8 p.c.) of the predicted value and forced expiratory volume in 1 s (FEV1) to 50 p.c. (ń 15.5 p.c.) of the predicted value. Postoperatively, slight improvement was achieved to 79.8 p.c. (ń 12.9 p.c.) for VC and 69.2 p.c. (ń 12.7 p.c.) for FEV1. Blood gas analysis showed decreased value in majority of the patients before operation and significant improvement in postoperative evaluation: Conclusion: Perfusion and spirometry improves significantly in patients with CPE after the lung decortication but function of the affected lung remains impaired. There was no influence of the age, gender, side of the disease, bacteriology or duration of the empyema before operation on lung function.

96/2523

Tytuł oryginału: 2- Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice.
Autorzy: Borowicz Kinga K., Łuszczki Jarogniew, Czuczwar Stanisław J.
Źródło: Eur. Neuropsychopharmacol. 2002: 12 (2) s.173-179, il., tab., bibliogr. [28] poz.
Sygnatura GBL: 313,361

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: 2-Chloroadenosine (0.25 - 1 mg/kg) significantly raised the threshold for electroconvulsions in mice. This preferential adenosine A1 receptor agonist (at 0.125 mg/kg) significantly potentiated the protective activity of carbamazepine against maximal electroshock-induced seizures in mice. 2-Chloroadenosine (1 mg/kg) showed also anticonvulsive efficacy against pentylenetetrazol-evoked seizures, raising the CD50 vale for pentylenetetrazol from 77.2 to 93.7 mg/kg. The drug (at 0.5 mg/kg) significantly enhanced the protective action of clonazepam in this test, decreasing its ED50 value from 0.033 to 0.011 mg/kg. Moreover, aminophylline, a non-selective adenosine receptor antagonist (5 mg/kg), and 8-cyclopentyl-1,3-dimethylxanthine (8-CPX), a selective A1, adenosine receptor antagonist (5 mg/kg) reversed the 2-chloroadenosine (0.125 mg/kg)-induced enhancement of the protective activity of carbamazepine and clonazepam. 2-Chloroadenosine administered alone or combined with antiepileptic drugs, caused neither motor nor long-term memory impairment. Finally, the adenosine A1 agonist did not change the free plasma concentration of antiepileptic, so a pharmacokinetic factor is not probable. Summing up, 2-chloroadenosine potentiated the protective activity of both carbamazepine and clonazepam, which seems to be associated with the enhancement of purinergic transmission mediated through adenosine A1 receptors.

97/2523

Tytuł oryginału: The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. P. 1: Reduction of cytostatic effects of quinacrine mustard by caffeine.
Autorzy: Kapuściński Jan, Ardelt Barbara, Piosik Jacek, Zdunek Małgorzata, Darzynkiewicz Zbigniew
Źródło: Biochem. Pharmacol. 2002: 63 (4) s.625-634, il., tab., bibliogr. 45 poz.
Sygnatura GBL: 304,395

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Recently, accumulated statistical data indicate the protective effect of caffeine consumption against several types of cancer diseases. There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations is based on biological activation of such carcinogens by cytochromes that are also known for metabolism of caffeine. However, there is also numerous data indicating reverse effect on cytotoxicity of anticancer drugs that inhibit the action of topoisomerase I (e.g. Camptothecin or Topotecan) and topoisomerase II inhibitors (e.g. Doxorubicin, Mitoxantrone or mAMSA). In this work we tested the hypothesis that the caffeine protective effect is the result of sequestering of aromatic mutagens by formation of stacking (ă - ă) complex. As the models for the study we have chosen two well-known mutagens, that do not require metabolic activation: quinacrine mustard (QM, aromatic, heterocyclic nitrogen mustard) and mechlorethamine (NM2, aliphatic nitrogen mustard). The flow cytometry study of these agents' action on the cell cycle of HL-60 cells indicated that caffeine prevents the cytotoxic action of QM, but not that of NM2. The formations of stacking complexes of QM with caffeine were confirmed by light absorption, calorimetric measurements and by molecular modeling calculation. Using the statistical thermodynamics calculations we calculated the "neighborhood" association constant (KAC = 59 ń 2 M**-1) and enthalpy change (DeltaH**0' = -116 cal mol**-1); the favorable entropy change of complex formation (DeltaS**0' = 7.72 cal mol**-1 K**-1, ...

98/2523

Tytuł oryginału: The modulation by xanthines of the DNA-damaging effect of polycyclic aromatic agents. P. 2: The stacking complexes of caffeine with doxorubicin and mitoxantrone.
Autorzy: Piosik Jacek, Zdunek Małgorzata, Kapuściński Jan
Źródło: Biochem. Pharmacol. 2002: 63 (4) s.635-646, il., tab., bibliogr. 45 poz.
Sygnatura GBL: 304,395

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: Recently accumulated statistical data indicate the protective effects of caffeine consumption against several types of cancer diseases. There are also reports, about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations of this phenomenon is based on biological activation of such carcinogens by cytochromes that are also known for metabolism of caffeine. In the accompanying paper [Kapuścinski et al., this issue] we provide evidence (flow cytometry and the cell cycle analysis) that the cytostatic effects of caffeine (CAF) on two DNA alkylating agents, which do not require the biological activation, depend on their ability to form stacking (ă - ă) complex. In this study, we use physicochemical techniques (computer aided light absorption and microcalorimetry), and molecular modeling to examine previously published qualitative data. This is published both by our and other group's data, indicates that CAF is able to modify the cytotoxic and/or cytostatic action of the two well known antitumor drugs doxorubicin (DOX) and mitoxantrone (MIT). To obtain the quantitative results from the experimental data we used the statistical-thermodynamical model of mixed aggregation, to find the association constants KAC of the CAF-drug interaction (128 ń 10 and 356 ń 21 M**-1 for DOX-CAF and MIT-CAF complex formation, respectively). In addition, the favorable enthalpy change of CAF-MIT (DeltaH = -11.3 kcal/mol) was measured by microcalorimetry titration. The molecular modeling (semi-empirical and force field method)...

99/2523

Tytuł oryginału: Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias.
Autorzy: Konopka Bożena, Paszko Zygmunt, Janiec-Jankowska Aneta, Goluda Marian
Źródło: Cancer Lett. 2002: 178 (1) s.43-51, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 306,023

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometrial carcinomas. In 45.8 p.c. (27/59) of carcinomas, 36 somatic mutations were detected in PTEN gene. In seven carcinomas, two mutations and in one carcinoma there mutations coexisted simultaneously. Moreover in 33.3 p.c. (2/6) of hyperplasia cases mutations were shown. Most identified mutations (57.9 p.c.) were present in exons 5 and 8, less frequently in exons 2 (15.8 p.c.) and 7 (13.2 p.c.) and they were least frequent in exons 1 and 3 (5.3 p.c. each). No mutations were found in exons 4, 6 and 9. Of all identified mutations, 73.7 p.c. of these resulting in truncated protein were present due to deletions, insertions and nonsense mutations. Missense mutations accounted for 13.2 p.c. of mutations and they were present only in exon 5. One point mutation (2.5 p.c.) was in intronic splice site. The remaining 10.5 p.c.of mutations were neutral polymorphisms. No statistically significant correlation were found between the frequency of PTEN gene mutations and the clinical stage of endometrial carcinomas. However, evident statistically significant, reverse correlation were observed between the frequency of mutations and the grade of morphological differentation of the diseases (Xý = 7.2393, ŕ = 0.0071). In conclusion, our data support the view that PTEN gene mutations are frequent events involved in development of endometrial carcinomas in women.

100/2523

Tytuł oryginału: Accuracy of linear endoscopic ultrasonography in the evaluation of patients with suspected common bile duct stones.
Autorzy: Kohut M., Nowakowska-Duława E., Marek T., Kaczor R., Nowak A.
Źródło: Endoscopy 2002: 34 (4) s.299-303, tab., bibliogr. 28 poz.
Sygnatura GBL: 305,439

Hasła klasyfikacyjne GBL:

radiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background and study aims: Endoscopic ultrasonography (EUS) with radial scanning is an efficient diagnostic tool where there is suspicion of common bile duct (CBD) stones. Little is known about the use of linear EUS in this condition. The aim of this study was to evaluate the diagnostic efficiency of linear EUS in a large group of patients suspected to have bile duct stones, using endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy and exploration of the CBD using a Dormia basket, or surgical choledochotomy with choledochoscopy, as diagnostic "gold standards". Patients and methods: 134 patients with clinical suspecion of CBD stones were included in the study and prospectively evaluated, using EUS, and ERCP with endoscopic sphincteroctomy (127 patients), or choledochotomy with choledochoscopy where ERCP was unsuccessful (seven patients). EUS was done before ERCP using an echo endoscope (Pentax FG 32 UA; 5 - 7.5 MHz) and Hitachi EUB 405 ultrasound machine. ERCP was done using the TFJ 100 or TJ 20 Olympus duodenoscope. ERCP was carried out within a mean of 2 days after EUS. The longest time between EUS and ERCP was 3 days. The examiners were binded to the results of the other method used. Results: CBD stones were found in 91 (68 p.c.) patients at ERCP with ES or at surgery. The correct diagnosis was established by EUS in 85 patients. The remaining 43 patients without CBD stones were correctly diagnosed in 41 cases by means of EUS, giving an accuracy of 94 p.c., specificity of 93 p.c., a positive predictive value of 98 p.c., a negative predictive value of 87 p.c., and a Youden's index of 98 p.c....

101/2523

Tytuł oryginału: The respriation of mitochondria from human skeletal muscle coupled to ATP synthesis is not impaired in pH 6.45 medium but is depressed at pH 7.8.
Tytuł polski: Oddychanie mitochondriów mięśnia szkieletowego człowieka skojarzone z syntezą ATP - bez zmian w środowisku o pH 6,45, hamowanie w pH 7,8.
Autorzy: Popinigis Jerzy, Antosiewicz Jędrzej, Crimi Massimo, Kaczor Jan Jacek, Bargossi Alberto Mario, Mercuri Mario, Gruca Zbigniew, Lenaz Giorgio
Źródło: Med. Sport. 2002: 18 (1) s.11-24, il., tab., bibliogr. 40 poz., streszcz.
Sygnatura GBL: 313,155

Hasła klasyfikacyjne GBL:

pediatria

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: Cel pracy: W czasie pierwszych kilku sekund wysiłku fizycznego w wyniku działania enzymu kinazy kreatynowej, wnętrze komórki mięśniowej ulega alkalizacji - wg Conetta nawet do pH 7,8. W wyniku kontynuacji wysiłku i powstawania kwasu mlekowego dochodzi następnie do zakwaszenia cytosolu, a obniżenie pH do wartości 6,45 doprowadza do zatrzymania glikolizy. Celem niniejszej pracy było zbadanie jak zmiany pH środowiska z wartości 7,0 do 6,45 i z 7,0 do 7,8 będą wpływały na aktywność oddechową mitochondriów otrzymanych z mięśnia szkieletowego człowieka. Materiały i metody: mitochondria izolowano z mięśni szkieletowych pochodzących z zabiegów operacyjnych typu amputacji dokonywanych ze wskazań lekarskich. Pomiaru zużycia tlenu przez mitochondria dokonywano za pomocą klasycznej elektrody tlenowej Clarka. Stosowano środowiska o pH 7,0 lub 6,45, lub 7,8. Substratami były: glutaminian z jabłczanem, pirogronian z jabłczanem oraz mleczan z NAD. Wyniki: w przypadku oddychania wysoko sprzężonego z syntezą ATP krótka ekspozycja mitochondriów do warunków pH 6.45 nei zmieniała ich aktywności oddechowej. Wyjątkiem było utlenianie mlecznu z NAD, które ulegało zahamowaniu. Mitochondria, których oddychanie było słabiej skojarzone z syntezą ATP, nieznacznie zmniejszały zużycie tlenu w pH 6.45. Natomiast 50 proc. hamowania obserwowano w pH 6.45 w mitochondriach z uszkodzoną strukturą. Hamowanie oddychania obserwowano w pH 7.8, nawet w mitochondriach dobrze skojarzonych. Obniżenie pH z 7,0 ...

Streszczenie angielskie: Aim of the study: during the first seconds of exercise due to creatine kinase reaction the interior of the muscle cell becomes alkaline, and according to Connett reaches pH 7.8 When exercise continues, the cytosol - due to formation of lactic acid - becomes acidic and glycolysis stops when pH reaches value of 6.45. The aim of our research was to investigate how changes of the pH of the medium from 7,0 to 6.45 or from 7.0 to 7.8 would affect the respiratory activity of mitochondria from human skeletal muscle. Materials and methods: mitochondria were isolated from post amputationem muscles of patients undergoing surgery. Oxygen uptake was measured with the classical Clark type oxygen electorde in pH 7.0, pH 6.45 and pH 7.8 media. Glutamate + malate, or pyruvate + malate, or NAD + lactate were used as respiratory substrates. Results: The respiration that was tightly coupled to ATP synthesis was found not impaired by short exposure to medium with pH 6.45. Exception was lactate (+ NAD) oxidation, which was arrested at this pH. Slight inhibition of respiration at pH 6.45 was noted in loose-coupled mitochondria, but almost 50 p.c. inhibition was seen at pH 6.45 in disrupted mitochondria. The coupled respiration of mitochondria was found inhibited at pH 7.8. Lowering of pH from 7.0 to 6.0 did not affect the activity of complex IV of respiratory chain, but complex I was under these conditions inhibited 39 p.c. and complex III 53 p.c. Activity of complex IV was inhibited 36 ...

102/2523

Tytuł oryginału: The search for optimal treatment in relapsed and refractory acute myeloid leukemia.
Autorzy: Robak Tadeusz, Wrzesień-Kuś Agata
Źródło: Leuk. Lymphoma 2002: 43 (2) s.281-291, tab., bibliogr. 116 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Despite the significant progress in the treatment of AML during the last 5-10 years, 20-40 p.c. of patients still do not achieve remission with standard induction therapy. In addition, 50-70 p.c. of patients in CR are likely to relapse. A major limitation of successful AML therapy is intrinsic or acquired drug resistance. Several pharmacological inhibitors of mechanisms inducing chemoresistance in leukemic cells have been investigated. New cytotoxic drugs, agents with novel mechanisms of action, and new treatment strategies are currently being investigated. The management of refractory or relapsed AML patients is reviewed in this study.

103/2523

Tytuł oryginału: In vitro drug resistance profiles of adult acute lymphoblastic leukemia: possible explanation for difference in outcome to similar therapeutic regimens.
Autorzy: Styczyński Jan, Wysocki Mariusz
Źródło: Leuk. Lymphoma 2002: 43 (2) s.301-307, il., tab., bibliogr. 79 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Age has important prognostic impact in acute lymphoblastic leukemia (ALL). Adults with ALL have a worse prognosis compared to children. This may be due to different, unfavorable biology, poor treatment tolerance, drug resistance, higher expression of drug resistance related proteins. The lymphoblasts from adult ALL show an increased in vitro resistance to cytotoxic drugs, including prednisolone, dexamethasone, cytosine arabinoside, daunorubicin, L-asparaginase and methotrexate. Glucocorticoid resistance may be a fundamental difference between children, adolescents and adults with ALL, which may underlie different biological aspects and also explain the difference in prognosis. It seems that in vitro resistance to prednisolone with respect to the age might be a continuous variable in ALL patients, except infants. The greater the age, the higher the in vitro resistance to prednisolone. This may be due to induction of various defense mechanisms, such as an activation of P-glycoprotien, which develops throughout the life and protect the human against xenobiotics. Among a number of various drug resistance mechanisms, only several weak differences between adults and children with ALL have been reported including higher P-glycoprotein expression, lower methotrexate polyglutamate accumulation and possibly more often p53 gene mutations in adults. Intrinsic resistance, induction of drug resistance proteins expression during chemotherapy and co-existence of various mechanisms are common phenomena in adult ALL. It seems that age itself, more than drug resitance profile, reflects factors which have direct effect on chemotherapy response in adult ALL.

104/2523

Tytuł oryginału: G-CSF administered in time-sequenced setting during remission induction and consolidation therapy of adult acute lymphoblastic leukemia has beneficial influence on early recovery and possibly improves long-term outcome: a randomized multicenter study.
Autorzy: Hołowiecki Jerzy, Giebel Sebastian, Krzemień Sławomira, Krawczyk-Kuliś Małgorzata, Jagoda Krystyna, Kopera Małgorzata, Hołowiecka Beata, Grosicki Sebastian, Hellmann Andrzej, Dmoszyńska Anna, Paluszewska Monika, Robak Tadeusz, Konopka Lech, Maj Stanisław, Wojnar Jerzy, Wojciechowska Maria, Skotnicki Aleksander, Baran Wojciech, Cioch Maria
Źródło: Leuk. Lymphoma 2002: 43 (2) s.315-325, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

ludzie

Streszczenie angielskie: Sixty-four untreated adult acute lymphoblastic leukemia (ALL) patients were randomized to receive chemotherapy alone, n = 31 or chemotherapy and granulocyte colony stimulating factor (G-CSF), n = 33. During induction patients received G-CSF for 5 days between four weekly Epirubicin + Vcradministrations, starting 36 h after each application and finishing 48 h before the next one with the intention to possibly generate a cell cycle dependent protection of normal hematopoietic progenitors and to stimulate granulopoiesis. The complete remission (CR) rate equaled 94 p.c. in the G-CSF group and 87 p.c in controls. Patients who received G-CSF, if compared to the controls, had shorter granulocytopenia during induction and consolidation, displayed a lower infection rate, completed the induction-consolidation quicker and stayed shorter in hospital during induction, p 0.001 - 0.04. Follow-up at 2 years revealed a rather higher probability of survival (59 vs. 27 p.c., p = 0.04) and a lower relapse rate (32 vs. 60 p.c.) in G-CSF arm than in controls. The beneficial influence of G-CSF administered in time-sequenced fashion on survival needs further confirmation.

105/2523

Tytuł oryginału: Fludaraibine therapy in Waldenstrm's macroglobulinemia patients treated previously with 2-chlorodeoxyadenosine.
Autorzy: Lewandowski Krzysztof, Halaburda Kazimierz, Hellmann Andrzej
Źródło: Leuk. Lymphoma 2002: 43 (2) s.361-363, il., tab., bibliogr. 10 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:

hematologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Six patients with Waldenstrm's Macroglobulinemia (WM) resistant to previous 2-chlorodeoxyadenosine (2-CdA) therapy were treated with fludarabine. Both initial and subsequent therapy was administered according to the most widely used protocols. The median number of 2-CdA cycles given to the patients was 3.7 (range 2-5), while fludarabine was 1.7 (range 1-2). As a result partial remission was achieved in two patients and stabilization of the disease in the remaining four in spite of the inadequate response or progressive disease after 2-CdA therapy. Median monoclonal IgM concentration fell from 29.4 (range 11.6-37.1) to 16.4 g/l (range 3.8-29.1). At the same time hemoglobin concentration increased from median 114 (range 89-129) to 122 g/l (range 97-133). Side effects consisted of neutropenia (three patients) and thrombocytopenia (two patients). Two patients are alive with progression of the disease noted after 12 and 21 months of observation. One patients died as the result of cardiac disease, two other died of infection 5 and 16 months after cessation of therapy in the course of disease progression. The remaining patient was lost to follow-up after 10 months of observation with continuous stabilization. Our observation suggest that in WM patients resistant to 2-CdA, stabilization of the disease or even remission can be obtained with fludarabine.

106/2523

Tytuł oryginału: Production of proangiogenic cytokines during thalidomide treatment of multiple myeloma.
Autorzy: Dmoszyńska Anna, Bojarska-Junak Agnieszka, Domański Damian, Roliński Jacek, Hus Marek, Soroka-Wojtaszko Maria
Źródło: Leuk. Lymphoma 2002: 43 (2) s.401-406, il., tab., bibliogr. 26 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Recently a growing number of studies have suggested the efficacy of thalidomide (THAL) in the treatment of relapsed or resistant multiple myeloma. Some of these studies indicate that the thalidomide antimyeloma effect is associated with decreased vessel density. Here we first present our experience with THAL treatment and then focus on the determination of the role of proangiogenic cytokines during THAL therapy. Thirty relapsing or resistant multiple myeloma (MM) patients were treated with THAL at a median dose of 400 mg/daily. Eighteen responded to THAL therapy and 12 were resistant or intolerant to THAL. We determined the plasma level of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) as the main biological parameters associated with tumour angiogenesis. In addition I1-6 and TNFŕ levels were also assayed. Assessment of peripheral blood (PB) and bone marrow (BM) cytokine levels were done before and during THAL treatment at weeks 4 and 8 of therapy. In the responder group VEGF, bFGF I1-6 and TNFŕ concentrations were significantly decreased after four weeks of therapy both in PB and BM. In the non-responder group no significant changes in bFGF and VEGF levels were observed. However, a significant increase in IL-6 and TNF concentrations was evident. We conclude that the significant decrease of VEGF, bFGF, I1-6 and TNFŕ concentrations reflected response to THAL therapy. Also it seems that VEGF is a better marker of response to treatment than bFGF.

107/2523

Tytuł oryginału: Influence of the alpha-1-adrenergic receptor blocker doxazosin on exercise-induced hyperkalemia in hemodialysis patients.
Autorzy: Nowicki Michał, Waluś Tomasz, Kokot Franciszek
Źródło: Kidney Blood Press. Res. 2002: 25 (1) s.55-60, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,314

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: Background/Aim: Hyperkalemic responses to both physical exercise and ŕ-adreenergic stimulation are enhanced in patients with terminal renal failure. ŕ-Adrenergic blockade was found to protect against hyperkalemia during vigorous exercise in healthy men. The aim of the study was to examine the effects of the ŕ-adrenergic blocker doxazosin on exercise-induced hyperkalemia in hemodialysis patients. Methods: In a randomized, placebo-controlled, crossover design study, 15 anuric, chronic hemodialysis patietns were included. Doxazosin or placebo was given in a random order for 4 days before exercise. At the end of each phase of the study, a 30-min treadmill exercise test with a constant workload of 2 metabolic equivalents was performed followed by a 30-min recovery period. Results: The patients achieved 64 ń 3 and 62 ń 3 p.c. of maximal heart rate during the exercise test on doxazosin and placebo, respectively. The baseline plasma concentration of potassium was similar both on active treatment and on placebo (5.1 ń 0.2 mmol/l on doxazosin and 4.9 ń 0.1 mmol/l on placebo). The serum potassium concentration increased significantly and to a similar extent during the tests. The mean rates of potassium increment during exercise were 8.4 ń 1.5 ćmol/l/min on doxazosin and 6.9 ń 1.3 ćmol/l/min on placebo. During the recovery period, the serum potassium concentration significantly decreased in both arms of the study. There were no significant changes in plasma sodium, calcium, and phosphate levels during the tests. Hydrogen ion concentration in blood, serum insulin and glucose, and plasma aldosterone and renin activity were similar before the exercise tests...

108/2523

Tytuł oryginału: Characterization of histamine H2-like receptors in duck cerebral cortical membranes by [3H]tiotidine binding.
Autorzy: Zawilska Jolanta, Zalewska-Kaszubska Jadwiga, Przybysz Marzena, Nowak Jerzy Z.
Źródło: Neurosci. Lett. 2002: 319 (3) s.149-152, il., bibliogr. 18 poz.
Sygnatura GBL: 305,936

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ptaki

in vitro

Streszczenie angielskie: A selective (according to mammalian criteria) histamine (HA) H2-receptor radioligand ([3H]TIOT) was used to characterize HA receptors in duck cerebral cortex by an in vitro binding technique. The specific binding of [3H]TIOT to duck cerebral cortical membranes was found to be rapid, stable, saturable, reversible, and of high affinity. Saturation analysis resulted in a linear Scatchard plot suggesting binding to a single class of receptor binding sites with high affinity (Kd = 19.5 nM) and high capacity (Bmax - 356 fmol/mg protein). Competition studies showed the following relative rank order of potency of various HA receptor ligands to inhibit the [3H]TIOT binding: antagonists, tiotidine rantidine izolantidine ň cimetidine mepyramine thioperamide; agonists, HA ň 4-methylHA 2-methylHA dimaprit Rŕ-methylIHA. The biphasic nature of the displacement curve for HA and the effect of 5'-guanylimidodiphosphate indicate with [3H]TIOT represent either avian-specific H2-like HA receptors or a novel subtype of HA receptors, coupled to a signalling athway other than the adenylyl cyclase/cyclic adenosine monophosphate one.

109/2523

Tytuł oryginału: New stereocontrolled synthesis and biological evaluation of 5-(1'-Hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as potential cytotoxic agents.
Autorzy: Janecki Tomasz, Błaszczyk Edyta, Studzian Kazimierz, Różalski Marek, Krajewska Urszula, Janecka Anna
Źródło: J. Med. Chem. 2002: 45 (5) s.1142-1145, il., tab., bibliogr. 23 poz.
Sygnatura GBL: 312,133

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

in vitro

Streszczenie angielskie: A series of 3-methylidenetetrahydro-2-furanones 7 bearing various hydroxyalkyl substituents in position 5 were synthesized using novel diastereo- and enantioselective methodology. In vitro cytotoxicity data demonstrated that all prepared compounds were active against L-1210 and HL-60 tissue culture cells with 7e being the most potent (IC50 = 6.9 ćM). Also an increase in activity with an increase in lipophilicity of the substituents in the order H , alkyl phenyl was observed.

110/2523

Tytuł oryginału: Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma.
Autorzy: Kamiya Yuji, Puzianowska-Kuźnicka Monika, McPhie Peter, Nauman Janusz, Cheng Sheue-yann, Nauman Alicja
Źródło: Carcinogenesis 2002: 23 (1) s.25-33, il., tab., bibliogr. 59 poz.
Sygnatura GBL: 312,779

Hasła klasyfikacyjne GBL:

nefrologia

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Thyroid hormone (T3) regulates proliferation and differentiation of cells, via its nuclear receptors (TRs). These processes have been shown to be abnormally regulated during carcinogenesis. We have previously found aberrant expression of TRŕ and TRá mRNAs in renal clear cell carcinoma (RCCC), suggesting possible involvement of TRs in the carcinogenesis of RCCC. To understand the molecular actions of TRs in RCCC, cDNAs for TRá1 and TRŕ1 were cloned from 22 RCCC tissues and 20 surrounding normal tissues. Mutations were found in seven TRá1 and three TRŕ1 cDNAs. Two TRá1 cDNAs had a single mutation, while five TRá1 and three TRŕ1 had two or three mutations. Most of the mutations were localized in the hormone-binding domain. Using the TRs prepared by in vitro transcription/translation, we found that these mutations led to a loss of T3 binding activity and/or impairment in binding to thyroid hormone response elements (TREs). Furthermore, nuclear extracts from RCCC tissues also exhibited impairment in binding to TREs. These results indicate that the normal functions of TRs in RCCC tissues were impaired. Together with the aberrant expression patterns, these mutated TRs could contribute to the carcinogenesis of RCCC.

111/2523

Tytuł oryginału: Ludwik Hirszfeld as I remember him [1884-1954].
Autorzy: Skurska Zofia
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.5-8
Sygnatura GBL: 304,223

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

historia XX wieku

Temat osobowy:

Hirszfeld

Ludwik 1844-1954

112/2523

Tytuł oryginału: Remembering Professor Ludwik Hirszfeld [1884-1954].
Autorzy: Benendo-Kapuścińska Bogusława
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.9-11, il.
Sygnatura GBL: 304,223

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

historia XX wieku

Temat osobowy:

Hirszfeld

Ludwik 1884-1954

113/2523

Tytuł oryginału: Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal, ... and get ready to face autoimmunity.
Autorzy: Tirapu Inigo, Mazzolini Guillermo, Rodriguez-Calvillo Mercedes, Arina Ainhoa, Palencia Belen, Gabari Izaskun, Malero Ignacio
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.13-18, bibliogr. 62 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: Cellular immune responses can destory cancer cells, achieving the cure of experimental malignancies. An exapanding wealth of knowledge on the molecular basis of how to prime and amplify a T cell response has fueled a number of strategies successful at treating estabilished tumors (rather than merely preventing tumor grafting). The most efficacious approaches operate at different stages, including: 1) priming the immune response using tumor antigen-expressing dendritic cells or tumor cells transfected with genes that render them immunogenic, 2) sustaining and amplifying immunity using agonistic monoclonal antibodies against costimulatory molecules or immune-potentiating cytokines, and 3) eliminating mechanisms that self-regulate the strenght of the immune response, such as inhibitory receptors or regulatory T cells. A rational combination of such approaches holds great hope for cumulative and synergistic effects, but there is also evidence that they can open the flood-gates for unwanted inflammatory reactions. The next decade can be envisioned as the time when the first reproducibly efficacious combination regimes for cancer immunotherapy will become available and videly used in the clinic, as clinicians learn the best strategies and try to harness their potentially damaging effects.

114/2523

Tytuł oryginału: Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies.
Autorzy: Sadowski-Debbing Kenneth, Coy Johannes F., Mier Walter, Hug Hubert, Los Marek
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.19-34, il., tab., bibliogr. 113 poz.
Sygnatura GBL: 304,223

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is carefully controlled by a philogenetically conserved death program, which is indispensable for the homeostasis and development of higher organisms. Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. In vitro studies have demonstrated the requirement of caspase activity for both the triggering phase as well as the execution of apoptosis, thus providing a molecular base for the fine-tuning of this process by pharmacological agents. The precise roles of the individual caspases in vivo and their functional relation to each other have been best demonstrated in genitically modified animals. The generation of single caspase-deficient mice have confirmed most of the data obtained in vitro and exposed some new aspects previously undetected in teh cell culture system. Interestingly, inactivation of many caspases revealed not only their expected participation in apoptotic as well as in the maturation of cytokines, but also provided hints about the role of at least some caspases in cell differentiation and stimulatory responses. In this review we will discuss what these studies have unveiled about the role of individual caspases in development, apoptosis, and inflammation, with particular focus on their role beyond the apoptotic process.

115/2523

Tytuł oryginału: The role of the innate and adaptive immune responses in Acanthamoeba keratitis.
Autorzy: Niederkorn Jerry Y.
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.53-59, bibliogr. 49 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

okulistyka

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: Infections of the corneal surface are an important cause of blindness. Protozoal, viral, bacterial, and helminthic infections of the cornea account for up to 9 milion cases of corneal blindness. Free-living amoebae of the genus Acanthamoeba produce a progressive infection of the cornea called Acanthamoeba keratitis. Disease is usually transmitted by Acanthamoeba trophozoites bound to soft contact lenses. Infection of the cornea is initiated when the parasite binds to the corneal epithelial surface. Recrudescence can occur and suggests that the adaptive immune response is not aroused by corneal Acanthamoeba infections. Systemic immunization with Acanthamoeba antigens elicits robust Th1 cell-mediated immunity and serum IgG antibody, yet fails to prevent the development of Acanthamoeba keratitis. However, immunization via mucosal surfaces induces anti-Acanthamoeba IgA antibodies in the tears and provides solid protection against the development of Acanthamoeba keratitis. Unlike other immune effector mechanisms that rely on cytolysis, inflammation, release of toxic molecules, or the induction of host cell death, the adaptive immune apparatus prevents Acanthamoeba infections of the cornea by simply preventing the attachment of the parasite to the epithelial surface. The beauty of this mechanisms lies in its exquisite simplicity and efficacy.

116/2523

Tytuł oryginału: Thermal glycation of proteins by D-glucose and D-fructose.
Autorzy: Kańska Urszula, Boratyński Janusz
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.61-66, il., tab., bibliogr. 28 poz.
Sygnatura GBL: 304,223

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The dry thermal glycation method was used to conjugate D-glucose and D-fructose with bovine serum albumin. Reactions were conducted at 50-104řC for 30 min. Depending on temperature, different levels of substitution were achieved. In the case of D-glucose, average substitution levels of up to 53 mol glucose/mol bovine serum albumin were obtained. D-fructose turned out to be less reactive than D-glucose. The pH of the reaction mixture was also found to affect the efficacy of the glycation reaction. The levels of substitution were estimated using matrix-assisted laser desorption/ionisation time -of-flight mass spectrometry and SDS-polyacrylamide gel electrophoresis. Glycated molecules, and a process of glycation itself are implicated in diabetes complications. Hypothetically bovine spongiform encephelopathy (BSE) was also derived from glycation.

117/2523

Tytuł oryginału: Glycoforms of six serum glycoproteins in a patient with congenital disorder of glycosylation type I.
Autorzy: Ferens-Sieczkowska Mirosława, Zwierz Krzysztof, Midro Alina, Kątnik-Prastowska Iwona
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.67-73, il., tab., bibliogr. 29 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

pediatria

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: In this paper the occurrence and relative content of defectively glycosylated serum glycoforms in transferrin (Tf), ŕ1-acid glycoprotein (AGP), haptoglobin (Hp), ŕ1-antitripsin (ŕ1-AT), ŕ2-macroglobulin (ŕ2-MG) and ceruloplasmin (Cpl) in the serum of a patient with congenital disorder of glycosylation type I are reported. Blood samples were taken when the patient was 14 years old and then after a one-year interval. The patterns of glycoforms in both samples were compared. In 4 out of 6 examined glycoproteins, glycoforms lacking one and two oligosaccharide chains occurred. "Underglycosylated" glycoforms of ŕ2-MG and Cpl were not clearly detectable. Tf was shown to be affected with this defect to a higher extent than other glycoproteins, containing only 30 p.c. properly glycosylated molecules and also as much as 30 p.c. of the molecules lacking two glycan units. In Hp and ŕ1-AT the proportions of properly and defectively glycosylated forms were similar. This properly glycosylated form comprised 47 p.c. of the Hp and 51-55 p.c. of the ŕ1-AT molecules. As in AGP and Tf, about 30 p.c. the of molecules lacked one glycan unit. Twenty-one percent of the Hp molecules were devoid of two glycans, and this amount slightly increased in the course of the year. In ŕ1-AT, 19 and 17 p.c. of the molecules lacked two glycans in both samples, respectively. Only in AGP we did find a substantial difference between the two blood samples. In the course of the year, the amount of the form lacking 2-chains decreases from 12 to 3 p.c., resulting in a simultaneous icrease in the forms lacking...

118/2523

Tytuł oryginału: Comparison of leukocyte populations from bronchoalveolar lavage and induced sputum in the evaluation of cellular composition and nitric oxide production in patients with bronchial asthma.
Autorzy: Bieńkowska-Haba Małgorzata, Cembrzyńska-Nowak Monika, Liebhart Jerzy, Dobek Rafał, Liebhart Ewa, Siemieniec Iwona, Panaszek Bernard, Obojski Andrzej, Małolepszy Józef
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.75-82, il., tab., bibliogr. 34 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: Bronchoalveolar lavage (BAL) or induced sputum (IS) techniques may provide lukocytes for the evaluation of airway inflammatory response in bronchial asthma. The aim of the present study was to compare features of leukocyte populations obtained by the two diffrent methods regarding the cell types and their activity in patients with bronchial asthma. The nitric oxide (NO) level released from the cells was measured as a marker of their activity. Pulmonary leukocytes were obtained from the BAL and IS of 11 asthmatic patients in stable condition at the time of the study. The BAL and IS leukocyte populations varied in cell count and NO production. Macrophages were the predominant leukocyte population in BAL (median (ME) = 83.0 p.c., range 67.9 - 88.4 p.c.), whereas sputum sediments were found to consist mainly of neutrophils (Me = 55.7 p.c., range 29.0 - 64.9 p.c.). The IS leukocytes released much more NO (p = 0.0022) than the BAL leukocytes released much more NO (p=0.0022) than the BAL leukocytes. In spite of these quantitative differences, a similar pattern of NO production was observed in BAL and in IS cells. Both BAL and IS leukocyte populations producted almost the same amounts of NO before and after lipopolysaccharide stimulation (p=0.9063, p= 0.4801, respectively). Furthermore, a slight positive correlation Spearman's rank (Rs)=0.5578, p=0.0594) was noticed between the neutrophil percentages and NO levels produced by BAL cells, whereas in IS a statistically significant correlation between the percentage of neutrophils and the levels of NO (Rs=0.6643, p=0.0184) was observed...

119/2523

Tytuł oryginału: The adipose tissue - a novel endocrine organ of interest to the nephrologist.
Autorzy: Więcek Andrzej, Kokot Franciszek, Chudek Jerzy, Adamczak Marcin
Źródło: Nephrol. Dial. Transplant. 2002: 17 (2) s.191-195, il., bibliogr. 39 poz.
Sygnatura GBL: 312,872

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

120/2523

Tytuł oryginału: Efficacy of the new long-acting formulation of lanreotide (Lanreotide Autogel) in the management of acromegaly.
Autorzy: Caron Ph., Beckers A., Cullen D. R., Goth M. I., Gutt B., Laurberg P., Pico A. M., Valimaki M., Zgliczyński W.
Źródło: J. Clin. Endocrinol. Metab. 2002: 87 (1) s.99-104, il., tab., bibliogr. 22 poz.
Sygnatura GBL: 310,620

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this study was to evaluate the efficacy and safety of this new ong-acting formulation in a large population of acromegalic patients previously responsive to lanreotide 30 mg, im (substained release microparticle formulation). Lanreotide Autogel was administered by deep sc injection every 28 d to 107 patients (54 males and 53 females; mean age, 54 ń 1.2 yr). All patients had been treated with lanreotide (30 mg) for at least 3 months before study entry and had a mean GH level less than 10 ng/ml after at least 4 subsequent im injections every 14 d (48 p.c.), 10 d (32 p.c.), or 7 d (20 p.c.). Treatment was switched from lanreotide 30 mg injected every 14, 10, or 7 d to 60, 90, or 120 mg lanreotide Autogel, respectively, every 28 d. After three fixed dose injections of lanreotide Autogel, mean lanreotide levels were similar to those obtained at steady state with lanreotide 30 mg. During lanreotide Autogel treatment, the control of acromegalic symptoms was comparable with that previoulsy achived during lanreotide 30 mg treatment. After 3 injections of lanreotide Autogel, mean GH (2.87 ń 0.22 ng/ml) and IGF-I (317 ń 15 ng/ml) values were comparable with those recorded at the end of lanreotide 30 mg treatment (GH, 2.82 ń 0.19 ng/ml; IGF-I, 323 ń 16 ng/ml). GH levels below 2.5 ng/ml and age-/sex-normalized IGF-I were achived in 33 p.c. and 39 p.c. of patients during lanreotide 30 mg and lanreotide Autogel treatment, respectively...

121/2523

Tytuł oryginału: Surgical view of the treatment of patients with hepatoblastoma. Results from the First Prospective Trial of the International Society of Pediatric Oncology Liver Tumor Study Group (SIOPEL-1).
Autorzy: Schnater J. Marco, Aronson Danil C., Plaschkes Jack, Perilongo Giorgio, Brown Julia, Otte Jean-Bernard, Brugieres Laurences, Czauderna Piotr, MacKinlay Gordon, Vos Anton
Źródło: Cancer 2002: 94 (4) s.1111-1120, il., tab., bibliogr. 20 poz.
Sygnatura GBL: 311,015

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Background. Surgical resection is the cornerstone of treatment for patients with hepatoblastoma (HB). The Society of Pediatric Oncology Liver Tumor Study Group launched its first prospective trial (SIOPEL-1) with the intention to treat all patients with preoperative chemotherapy and delayed surgical resection. The objective of this article was to assess the assumed surgical advantages of primary chemotherapy. Methods. Between 1990 and 1994, 154 patients age 16 years with HB were registered on SIOPEL-1. The pretreatment extent of disease was assessed, and, after undergoing biopsy, patients were treated with cisplatin 80 mg/mý intravenously over 24 hours and doxorubicin 60 mg/mý intravenously over 48 hours by continuous infusion (PLADO). Generally, tumors were resected after four of a total of six courses of PLADO. Results. One hundred twenty eight patients underwent surgical resection (13 patients underwent primary surgery, and 115 patients underwent delayed surgery after PLADO). A pretreatment surgical biopsy was performed in 96 of 128 patients (75 p.c.). Biopsy complications occurred in 7 of 96 patients (7 p.c.). Twenty-two patients showed pulmonary metastases at the time of diagnosis, and 7 patients underwent thoracotomy. Operative morbidity and mortality were 18 p.c. and 5 p.c., respectively. Complete macroscopic surgical resection was achieved in 106 patients (92 p.c.), including 6 patients who underwent orthotopic liver transplantation. The actuarial 5-year event free survival (EFS) rate for all 154 patients in the study was 66 p.c., and the overall survival (OS) rate was (75 p.c.)...

122/2523

Tytuł oryginału: Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-ŕ system activity.
Autorzy: Strączkowski Marek, Lewczuk Piotr, Dzienis-Strączkowska Stella, Kowalska Irina, Stępień Agnieszka, Kinalska Ida
Źródło: Metabolism 2002: 51 (1) s.75-78, il., tab., bibliogr. 29 poz.
Sygnatura GBL: 303,583

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Intercellular adhesion molecule-1 (ICAM-1) is 1 of the possible factors linking obesity and diabetes with cardiovascular disease, however, the mechanism of the increase in ICAM-1 concentration in obesity remains unclear. Therefore, the aim of the present study was to assess plasma soluble ICAM-1 (sICAM-1) levels on obese subjects with normal glucose tolerance and to evaluate whether those levels may be related to insulin resistance and tumor necrosis factor-ŕ (TNFŕ) system activity. The study was performed in 8 lean and 15 obese subjects. Anthropometric and biochemical parameters were measured, and insulin sensitivity was evaluated using the euglycemic hyperinsulinemic clamp technique (insulin infusion, 50 mU x kg**-1 x h**-1). Obese subjects were markedly more hyperinsulinemic and insulin resistant and had higher plasma soluble TNF receptor 2 (sTNFR2) and sICAM-1 levels. sICAM-1 was related positively to body mass index (BMI), waist-to-hip ratio (WHR), percent of body fat, glycated hemoglobin (HbA1c), plasma insulin and triglycerides (TG), TNFŕ, and sTNFR2 and negatively to insulin sensitivity. Multiple regression analysis showed that only sTNFR2 and insulin sensitivity were independent predictors of sICAM-1 concentrations and were responsible for 66 p.c. of sICAM-1 variability. We conclude that an increase in plasma sICAM-1 concentration in obesity is related to TNFŕ system activation and insulin resistance.

123/2523

Tytuł oryginału: Enhanced T cells interactions with extracellular matrix proteins in infertile women with endometriosis.
Autorzy: Jerzak Małgorzata, Baranowski Włodzimierz, Rechberger Tomasz, Górski Andrzej
Źródło: Immunol. Lett. 2002: 81 (1) s.65-70, il., tab., bibliogr. 53 poz.
Sygnatura GBL: 312,663

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Essential features of endometriosis involve interactions with extracellular matrix (ECM). Recent data emphasize the important role of ECM proteins in the regulation of T cell function. The aim of this study was to determine activated T cell adhesion to ECM proteins in infertile women with endometriosis. Nine women with endometriosis diagnosed by laparoscopy according to the Revised American Fertility Society classification and ten normal healthy women with a previous successful pregnancy outcome were studied. We investigated phorbol acetate myristate (PMA) or phytohemaglutinin (PHA) activated peripheral blood T cell adhesion to the following proteins of ECM: collagen IV (C-IV), elastin (E) and fibronectin (Fn). In addition, CD4, CD8, CD29, CD45RO exspression on peripheral CD3+ T cells were studied using flow cytometry. We determine that PHA-activated T cell adhesion to C-IV and Fn are significantly higher in infertile women with endometriosis when compared to normal healthy women (P 0.05). No significant differences were noted in T cell's surface antigens expression between study groups. Our data suggest the existence of disturbed T cell-ECM interactions in infertile women with endometriosis. Further studies are needed to determine the role of these abnormalities in the pathogenesis of endometriosis.

124/2523

Tytuł oryginału: Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris.
Autorzy: Cisło Maria, Hałasa Jolanta, Wąsik Feliks, Nockowski Piotr, Prussak Magdalena, Mańczak Maria, Kuśnierczyk Piotr
Źródło: Immunol. Lett. 2002: 80 (3) s.145-149, tab., bibliogr. 58 poz.
Sygnatura GBL: 312,663

Hasła klasyfikacyjne GBL:

dermatologia i wenerologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B. However, HLA-linked complement component polymorphic genes were not extensively studied. Therefore, we typed 67 psoriatic patients for alleles of the HLA-linked complement components BF, C4A and C4B. Alleles of C3, encoded on another chromosome, were established in parallel as a negative control. Frequencies in patients were compared with thise in unrelated healthy controls, 100 individuals for C4A and C4B, 890 for BF and 4719 for C3. We found no association of BF alleles with disease, similarly to C3. Among C4 alleles, C4B*3 was present in 13,4 p.c. of patients as compared with 1 p.c. of controls (OR, 15.36; 95 p.c. CI, 1.897 - 124.42; P = 0.0009), and C4A*6 was present in 19.4 p.c. of patients versus 7 p.c. of controls (OR, 3.20; 95 p.c. CI, 1.202 - 8.508; P = 0.0155). The high frequency of C4B*3 in psoriatics has not been described so far. These results suggest a contribution of C4 genes themselves or a closely linked gene to the susceptibility to psoriasis.

125/2523

Tytuł oryginału: Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart.
Autorzy: Kurzelewski Michał, Czarnowska Elżbieta, Beręsewicz Andrzej
Źródło: Eur. J. Pharmacol. 2002: 434 (1/2) s.95-107, il., tab., bibliogr. s. 105-107
Sygnatura GBL: 312,088

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

Świnki morskie

Streszczenie angielskie: This study addressed the hypothesis that endothelin promotes neutrophil accumulation in ischemic/reperfused myocardium, not only via its direct effect on neutrophils, but also because it mediates post-ischemic endothelial injury. Langendorff-perfussed guinea-pig hearts were subjected to 30 min ischemia/35 min reperfusion, and infusion of neutrophils between 15 and 25 min of reperfusion. The infusion of the endothelin ETA/ETB receptor antagonist, tezosentan, the endothelin ETA receptor antagonist, BQ 123 [cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-], and superoxide dismutase was terminated at reperfusions, 5 min before the start of the neutrophil infusion, to avoid the contact of the drugs with neutrophils. Coronary flow responses to acetylcholine and nitroprusside were used as measures of endothelium-dependent and -independent vascular function, respectively. Neutrophil adhesion and endothelium glycocalyx ultrastructure were assessed in histological preparations. Ischemia/reperfusion resulted in a 54 p.c.-impaired acetylcholine response, endothelium glycocalyx disruption, and enhanced neutrophil adhesion (21.6 p.c. of microvessels contained neutrophils vs. 2.6 p.c. in sham group), the latter prevented by a selectin blocker, sulfatide, 20 ćg/ml. These alterations were completely prevented by 0.5 and 5 nM, but not 0.05 nM, tezosentan, and were greatly attenuated by BQ 123, 1 and 10 nM. The glycocalyx-protective effect of these interventions preceded their effect on neutrophil adhesion. Superoxide dismutase, 150 IU/ml, reported before by us to protect post-ischemic endothelium glycocalyx, here prevented the post-ischemic endothelial dysfunction and neutrophil adhesion...

126/2523

Tytuł oryginału: Successful use of activated recombinant factor VII to control bleeding abnormalities in a patient with a left ventricular assist device.
Autorzy: Ziętkiewicz Mirosław, Garlicki Mirosław, Domagała Jerzy, Wierzbicki Karol, Drwiła Rafał, Pfitzner Roman, Dziatkowiak Antoni
Źródło: J. Thorac. Cardiovasc. Surg. 2002: 123 (2) s.384-385, bibliogr. 5 poz.
Sygnatura GBL: 310,230

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

127/2523

Tytuł oryginału: N-acetyltransferase 2 polymorphism in sporadic Parkinson's disease in a Polish population.
Autorzy: Białecka Monika, Gawrońska-Szklarz Barbara, Droździk Marek, Honczarenko Krystyna, Stankiewicz Jan
Źródło: Eur. J. Clin. Pharmacol. 2002: 57 (12) s.857-862, il., tab., bibliogr. 28 poz.
Sygnatura GBL: 312,148

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: Objective: A genetic background of Parkinson's disease has been suggested, including genes implicated in xenobiotic metabolism. So far, many candidate genes responsible for the occurrence of the disease have been enumerated. This study was carried out to determine the presence of N-acetyltransferase 2 polymorphism in Parkinson's disease patients in a Polish population. Methods: Fifty-four patients with diagnosed sporadic Parkinson's disease and 81 healthy individuals were enrolled into the study. The N-acetyltransferase 2 alleles (*4, *5, *6 and *7) were identified using polymerase chain reaction-restriction fragment length polymorphism methods with DNA extracted from peripheral blood. Results: A preponderance of slow acetylators in patients with Parkinson's disease was demonstrated. Among 54 subjects with parkinsonism, 64.8 p.c. were homozygous for two mutated alleles responsible for the slow-acetylator phenotype. In the control group, a predominance of fast acetylators was noted. Subjects homozygous and heterozygous with genotypes determining fast acetylation constituting 53 p.c. of subjects, whereas 47 p.c. were slow acetylators. Comparison of the two groups of the study, i.e. Parkinson's disease and healthy individuals, revealed a statistically significant predominance of slow acetylators in Parkinson's disease patients (P 0.05). The risk of Parkinson's disease development was more than two times greater in slow acetylators than healthy subjects. The frequency of point mutations was similar both in patients with Parkinson's disease and the healthy cotrols. Conclusion: Slow-acetylation genotype may be an important factor of individual susceptibility to Parkinson's disease.

128/2523

Tytuł oryginału: Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in different histological variants of rheumatoid synovitis.
Autorzy: Klimiuk P. A., Sierakowski S[tanisław], Latosiewicz R[obert], Cylwik B[ohdan], Skowroński J[an], Chwiecko J.
Źródło: Rheumatology 2002: 41 (1) s.78-87, il., tab., bibliogr. 50 poz.
Sygnatura GBL: 303,271

Hasła klasyfikacyjne GBL:

reumatologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Objective. Rheumatoid synovitis is characterized by an invasive and tissue-destructive infiltrate of lymphocytes, macrophages and synoviocytes. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) produced by these cells are important in the remodelling of the articular tissue in rheumatoid arthritis (RA). The aim of this study was to explore whether the serum concentrations of MMPs and their inhibitors were correlated with the histological appearance of the disease. Methods. Tissue and serum samples were obtained from 37 patients with clinically active RA and 30 with osteoarthritis (OA). Morphological analysis allowed the division of RA synovial specimens into two distinct types. In 22 samples only diffuse infiltrates of mononuclear cells without further microanatomical organization were found. In 15 specimens we observed lymphocytic conglomerates with germinal centre-like structures. Serum concentrations of interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), gelatinase B (MMP-9), TIMP-1 and TIMP-2 were measured with an ELISA technique. Results. Unique serum profiles of MMPs and TIMPs were identified in each of the two histological types of RA synovitis. The serum concentrations of MMP-1, MMP-3 and MMP-9 were higher in RA patients than in OA patients used as a control group (P 0.001 for all comparisons). These three MMPs dominated in the serum of RA patients with follicular synovitis compared with those diffuse synovitis (P 0.05, P 0.01 and P 0.001 respectively)...

129/2523

Tytuł oryginału: GLP-1 as a satiety fctor in children with eating disorders.
Autorzy: Tomasik P. J., Sztefko K., Malek A.
Źródło: Horm. Metab. Res. 2002: 34 (2) s.77-80, il., tab., bibliogr. 24 poz.
Sygnatura GBL: 312,226

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: GLP-1, with its insulinotropic properties and direct action on satiety center in the brain, may be the main hormone regulating the amount of ingested food. In this study, GLP-1 secretion was investigated in age-matched adolescent girls (14 ń 2 years): 13 with anorexia nervosa (BMI 14.8 ń 1.4 kg/mý), 13 with simple obesity (BMI 33.0 ń 3.3 kg/mý) and 10 healthy girls as a control group (BMI 21.6 ń 0.7 kg/mý). Each girl was subjected to OGTT and standard meal tests after a 12h overnight fast. Blood samples were collected before and 15, 30, 60, and 120 min after the stimulation. The mean fasted GLP-1 levels in simple obesity group (1.6 ń 0.3 pmol/l) and in anorexia nervosa group (1.7 ń 0.3 pmol/l) were significantly lower than those in the control group (2.6 ń 0.4 pmol) (p 0.05) in both cases). The highest peak concentration of GLP-1 was observed in the control group after both stimuli. In each group, the mean integrated GLP-1 outputs were almost twice as high after OGTT than after the test meal (p 0.001 in each case). In our opinion, low secretion of GLP-1 in girls with simple obesity may seriously and negatively influence the course of this disease. On the other hand, low GLP-1 levels in girls with anorexia nervosa are beneficial and promote appetite.

130/2523

Tytuł oryginału: Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin.
Autorzy: Kalinowski Leszek, Dobrucki Lawrence W., Brovkovych Viktor, Maliński Tadeusz
Źródło: Circulation 2002: 105 (8) s.933-938, il., bibliogr. 17 poz.
Sygnatura GBL: 311,033

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Although statins preserve endothelial function by reducing serum cholesterol levels, it has been suggested they may also stimulate nitric oxide (NO) synthase in endothelium with concurrent increase in superoxide (O2-) generation, leading to impairment of NO activity. Therefore, measurements of biologically active NO and O2 - in endothelium after exposure to the HMG-CoA reductase inhibitor cerivastatin were undertaken to evaluate its potential effect on NO biological activity. Methods and Results - Highly sensitive electrochemical NO and O2 - microsensors were placed near the surface of a single human umbilical vein endothelial cell, and the kinetics of NO and O2 - release were recorded in vitro. Cerivastatin demonstrated a time-dependent effect on NO release in endothelial cels. The initial release (approximately the first 3 minutes) was concentration-dependent (0.01 to 10 ćmol/L) and was similar to that observed for typical NO synthase agonists calcium ionophore or acetylcholine. Cerivastatin stimulated NO release at a favorable rate and scavenged O2-, which led to the preservation of the active concentration of NO. The sustained effect (after ÷ 6 hours) of cerivastatin on endothelium was associated with an ÷ 35 p.c. increase in NO release as compared with the initial effect. In contrast to the initial effect, the sustained effect of cerivastatin was shown at concenrations ÷ 100-fold lower and was dependent on inhibition of endothelial HMG-CoA reductase. Conclusions - These data provide direct evidence to prove that in the presence of cerivastatin, the NOS system in endothelium operates with high efficiency toward increasing NO activity by activation of NO release and by concurrent inactivation of O2-.

131/2523

Tytuł oryginału: Juvenile idiopathic arthritis (JIA) is primarily associated with HLA-DR8 but not DQ4 on the DR8-DQ4 haplotype.
Autorzy: Smerdel A., Ploski R., Flato B., Musiej-Nowakowska E., Thorsby E., Forre O.
Źródło: Ann. Rheum. Dis. 2002: 61 (4) s.354-357, tab., bibliogr. 17 poz.
Sygnatura GBL: 310,264

Hasła klasyfikacyjne GBL:

reumatologia

genetyka

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Juvenile idiopathic arthritis (JIA) is strongly associated with the DR8-DQ4 haplotype. The genes encoding DR8 and DQ4 are in strong linkage disequilibrium (LD) and oocur together on the same HLA haplotype in almost all patients and controls. Because of the strong LD it is not clear whether DR8, DQ4, or both, are primarily associated with JIA. Objective: To unveil the primary association of JIA - that is, with DR8 or DQ4. Methods: DRB1, DQA1, and DQB1 alleles of 585 Norwegian and 47 Polish unrelated patients with JIA (categorised as pauciarticular and rheumatoid factor negative polyarticular JIA), and of 3155 Norwegian and 158 Polish unrelated controls, were typed using a polymerase chain reaction or oligonucleotide hybridisation and sequence-specific primers method. Results: Several haplotypes which encoded DR8 (that is, carried DRB1*08) and which did not encode DQ4 (that is, did not carry DQA1*0401) were found. Such haplotypes were found in three Norwegian patients and two controls (p = 0.029). In the Polish population such haplotypes were found among four patients with JIA and two controls (p = 0.025). No haplotypes which carried DQA1*0401 and DQB1*0402 in the absence of DRB1*08 were found, either among patients with JIA (Polish and Norwegian) or among the controls (Polish). Conclusion: On the DR8-DQ4 haplotype the DRB1*08 allele is primarily associated with JIA.

132/2523

Tytuł oryginału: Estrogen inhibits systemic T cell expression of TNF-ŕ and recruitment of TNF-ŕ+ T cells and macrophages into the CNS of mice developing experimental encephalomyelitis.
Autorzy: Ito Atsushi, Buenafe Abigail C., Matejuk Agata, Zamora Alex, Silverman Marc, Dwyer Jami, Vandenbark Arthur A., Offner Halina
Źródło: Clin. Immunol. 2002: 102 (3) s.275-282, il., tab., bibliogr. 40 poz.
Sygnatura GBL: 305,911

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: Estrogen treatment has been found to have suppressive activity in several models of autoimmunity. To investigate the mechanism of 17á-estradiol (E2) suppression of experimental autoimmune encephalomyelitis, we evaluated E2 effects on TNF-ŕ experssion in the central nervous system (CNS) and spleen of C57BL/6 mice immunized with MOG 35-55/CFA. Kinetic analysis demonstrated that E2 treatment drastically decreased the recruitment of total inflammatory cells as well as TNF-ŕ+ macrophages and T cell into the CNS at disease onset. In contrast, E2 had only moderate effects on the erlatively high constitutive TNF-ŕ expression by resident CNS microglial cells. E2 treatment also had profound inhibitory effects on expression of TNF-ŕ by splenic CD4+ T cells, including those responsive to MOG 35-55 peptide. We propose that the mechanism of E2 protection may involve both systemic inhibition of TNF-ŕ expression and local (CNS) ercruitment of inflammatory cels, with modest effects on TNF-ŕ expression by resident CNS microglial cells.

133/2523

Tytuł oryginału: Extent of, and factors associated with, delay to hospital presentation in patients with acute coronary disease (the GRACE registry).
Autorzy: Goldberg Robert J., Steg Philippe Gabriel, Sadiq Immad, Granger Christopher B., Jackson Elizabeth A., Budaj Andrzej, Brieger David, Avezum Alvaro, Goodman Shaun
Źródło: Am. J. Cardiol. 2002: 89 (7) s.791-796, il., tab., bibliogr. 15 poz.
Sygnatura GBL: 304,619

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: Our primary study aim was to examine extent of, and factors associated with, delay in seeking medical care in a large multinational registry of patients with acute myocardial infarction (AMI) and unstable angina pectoris. A secondary goal was to examine the relation between duration of prehospital delay and receipt and timing of coronary reperfusion strategies. Investigators from 14 countries are participating in the Global Registry of Acute Coronary Events (GRACE) project. The study sample consisted of 3,693 patients with ST-segment elevation AMI, 2,935 with non-ST-segment elevation AMI, and 3,954 patients with unstable angina hospitalized between 1999 and 2001. The average and median delay times were longest in patients with non-ST-segment elevation AMI (6.1 and 3.0 hours, respectively) followed by patients with unstable angina (5.6 and 3.0 hours) and those with ST-segment elevation AMI (4.7 and 2.3 hours). Approximately 41 p.c. of patients with ST-segment elevation AMI presented to the 94 study hospitals within 2 hours of the onset of acute coronary symptoms; the compared with approximately one third of patients with non-ST-segment elevation AMI and unstable angina. Several demographic and clinical characteristics were associated with prehospital delay. In patients with ST-segment elevation AMI, duration of prehospital delay was inversely related to the receipt of thrombolytic therapy, but was inconsistently related to the use pf percutaneous coronary interventions. The results of this study demonstrate that a large proportion of patients continue to exhibit prolonged delay in seeking medical care after the onset of acute coronary symptoms and remain in need of targeted educational efforts to reduce extent of delay.

134/2523

Tytuł oryginału: Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results.
Autorzy: Słowińska-Klencka Dorota, Klencki Mariusz, Sporny Stanisław, Lewiński Andrzej
Źródło: Eur. J. Endocrinol. 2002: 146 (1) s.19-26, il., tab., bibliogr. 38 poz.
Sygnatura GBL: 301,344

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Objective: The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic, value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find whether the changes in iodine supply have already influenced the clinical interpretation of cytological results. Methods: Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the years 1985-1999, were verified by reference to the results of postoperative examinations. The relative occurrences of selected cytological results in 1992-1999 were also compared (patients not subjected to surgery were included). Results: We have found that the frequenty of neoplastic lesions significantly decreased throughout the examined period (P 0.02). The ratio of the follicular carcinoma frequency increased from 1.7 during 1992-1993 up to 8.0 during 1998-1999 (P 0.05). The frequency of cytologically diagnosed chronic thyroiditis increased from 1.5 p.c. in 1992 to 5.7 p.c. in 1999 (P 0.001); the percentage of cytological diagnosis of 'follicular neoplasm' decreased during the same time (P 0.001). The risk of malignancy significantly lowered in the cytological diagnoses of 'follicular neoplasm' from 15 p.c. during 1985-1993 to 6 p.c. during 1996-1999 (P 0.05). Conclusions: The diagnostic value of FNAM during the period without proper iodine prophylaxis did not differ significantly from that during the last examined period. However, the changes in iodine supply have markedly and promptly affected the clinical significance of particular cytological results.

135/2523

Tytuł oryginału: Angiogenesis of endocrine gland tumours - new molecular targets in diagnostics and therapy.
Autorzy: Stępień H. M., Kołomecki K., Pasieka Z., Komorowski J., Stępień T., Kuzdak K.
Źródło: Eur. J. Endocrinol. 2002: 146 (2) s.143-151, tab., bibliogr. 96 poz.
Sygnatura GBL: 301,344

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Angiogenesis in one of the key stages in the development of neoplastic tumours, in which a small group of mutated cells transforms into a large malignant tumour metastasising to the neighbouring tissues and organs. The studies on the significance of neoangiogenesis in the progression of endocrine gland neoplasms have recently become one of the most rapidly evolving branches of molecular endocrinology. The induction of angiogenesis has been demonstrated to result from the imbalance between positive and negative factors which control this process. Our paper presents the results of current studies on the role of factors such as molecular markers of angiogenesis (e.g. vascular endothelial growth factor and basic fibroblast growth factor), metalloproteinases (which regulate the decomposition of the extracellular matrix) and their inhibitors, and adhesive molecules (e.g. soluble vascular cellular adhesion molecule-1 and soluble intracelular adhesion lecule-1) in the pathogenesis and diagnostics of endocrine gland tumours in humans. Also, we discuss new therapeutic strategies for inhibiting the growth of neoplasms by blocking the formation of blood vessels using angiogenesis antagonists, which inhibit various stages of angiogenesis. More and more data are being accumulated suggesting that these preparations could, in the near future, be used in the pharmacotherapy of some endocrine gland neoplasms.

136/2523

Tytuł oryginału: O**6-Alkylguanine-DNA-alkyltransferase activity in peripheral leukocytes, smoking and risk of lung cancer.
Autorzy: Boffetta Paolo, Nyberg Fredrik, Mukeria Anush, Benhamou Simone, Constantinescu Vali, Batura-Gabryel Halina, Brske-Hohlfeld Irene, Schmid Giovanni, Simonato Lorenzo, Pelkonen Pivi, Hall Janet
Źródło: Cancer Lett. 2002: 180 (1) s.33-39, tab., bibliogr. 25 poz.
Sygnatura GBL: 306,023

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: The level of activity of O**6-alkalguanine-DNA-alkytransferase (AGT), a DNA repair enzyme, in blood lymphocytes may be a marker of susceptibility to lung cancer. We measured the AGT activity level, expressed as plomes of repaired bases/mg protein, in leukocytes of 153 lung cancer cases (of whom 80 were never smokers) and 106 controls (76 never smokers) enrolled in eight centres from seven countries. Subjects were interviewed with respect to active smoking and exposure to environmental tobacco smoke (ETS). Among never smokers, the odds ratios (ORs) of lung cancer were 1.3 (95 p.c. confidence interval 0.5-3.9), 1.5 (0.6-4.1) and 1.4 (0.5-3.8) in quartiles of decreasing AGT activity level, as compared to the upper quartile (P value of test for linear trend 0.6). Corresponding ORs among smokers were 3.4 (0.9-13), 2.0 (0.5-8.3) and 0.4 (0.1-1.6) (P value of test for linear trend 0.4). No interaction was suggested between AGT activity level and either cumulative smoking or exposure to ETS. Reduced AGT activity was not clearly associated with increased lung cancer risk in either smokers or non-smokers. However, the small size of our study argues for a prudent interpretation of our results.

137/2523

Tytuł oryginału: Contrast echocardiography and medical economics: looking into the crystal ball.
Autorzy: Distante A., Dankowski R., Mincarone P., Leo C. G., Gianicolo E., Voci P., Morales M. A., Rovai D.
Źródło: Eur. Heart J. 2002: 4 supl. C s.C39-C47, tab., bibliogr. 78 poz.
Sygnatura GBL: 306,213

Hasła klasyfikacyjne GBL:

ekonomika

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The past decade has witnessed the development of contrast echocardiography. This technique has demonstrated clinical utility in some applications and extremely promising results have been reported for others, although there are still several obstacles to its acceptance by regulatory authorities and routine users. In addition, the eficacy and cost-effectiveness must be proven against 'gold standard' techniques, which in several cases are just accepted standards. Furthermore, the competition is quite strong both between new techniques and with established ones, and all of the imaging modalities need to find their most appropriate role within this comples environment.

138/2523

Tytuł oryginału: Plasma fibrinogen and troponin I in acute coronary syndrome and stable angina.
Autorzy: Gil Maciej, Zarębiński Maciej, Adamus Jerzy
Źródło: Int. J. Cardiol. 2002: 83 (1) s.43-46, il., tab., bibliogr. 10 poz.
Sygnatura GBL: 305,693

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: We aimed to determine whether there is a stratification among patients with different stages of coronary artery disease with respect to plasma fibrinogen levels, and to assess diagnostic value of plasma fibrinogen in comparison to troponin I in patients with acute coronary syndrome. Fifty-one consecutive patients presenting to our department with acute coronary syndrome within the last 24 h and 52 patients with stable angina with no episode of unstable disease within the last month were analysed. Forty-nine patients with acute coronary syndrome in which both troponin I and fibrinogen levels were prsent were further evaluated. Blood was collected on admission for routine laboratory tests. Statistical analysis was done using Student's t-test, Pearson correlation and chi-square test, P 0.05 being considered statistically significant. Plasma fibrinogen levels (g/l) were significantly higher in patients presenting with unstable than with stable angina (3.87 ń 1.2 vs. 3.26 ń 0.65 P = 0.002). We have found significant correlation between fibrinogen and troponin I levels in coexist and correlate. These results seem to confirm the role of this acute phase protein in the pathophysiology of acute coronary syndrome.

139/2523

Tytuł oryginału: Anthrapyridones, a novel group of antitumour non-cross resistant anthraquinone analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells.
Autorzy: Tarasiuk J., Stefańska B., Plodzich I., Tkaczyk-Gobis K., Seksek O., Martelli S., Garnier-Suillerot A., Borowski E.
Źródło: Br. J. Pharmacol. 2002: 135 (6) s.1513-1523, il., tab., bibliogr. s. 1522-1523
Sygnatura GBL: 301,182

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: 1. Multidrug resistance (MDR) to antitumour agents, structurally dissimilar and having different intracellular targets, is the major problem in cancer therapy. MDR phenomenon is associated with the presence of membrane proteins which belong to the ATP-binding cassette family transporters responsible for the active drug efflux leading to the decreased intracellular accumulation. 2. The search of new compounds able to overcome MDR is of prime importance. 3. recently we have synthesized a new family of anthrapyridone compounds. The series contained derivatives modified with appropriate hydrophobic or hydrophylic substituents at the side chain. 4. The interaction of these derivatives with erythroleukina K562 sensitive and K562/DOX resistant (overexpressing P-glycoprotein) cell lines has been examined. The study was performed using a spectrofluorometric method which allows to continuously follow the uptake and efflux of fluorescent molecules by living cells. 5. It was demonstrated that the increase in the lipophilicity of anthrapyridones favoured the very fast cellular uptake exceeding the rate of P-gp dependent efflux out of the cell. For these derivatives, very high accumulation (the same for sensitive and resistant cells) was observed and the in vitro biological data confirmed that these compounds exhibited comparable cytotoxic activity towards sensitive and P-gp resistant cell line. In contrast, anthrapyridones modified with hydrophylic substituents exhibited relatively low kinetics of cellular uptake...

140/2523

Tytuł oryginału: Carvedilol does not modulate moderate exercise-induced hyperkalemia in hemodialysis patients.
Autorzy: Nowicki M., Szewczyk-Seifert G., Klimek D., Kokot F[ranciszek]
Źródło: Clin. Nephrol. 2002: 57 (5) s.352-358, il., tab., bibliogr. s. 357-358
Sygnatura GBL: 312,466

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background and aim: Non-selective á-adrenergic blockers may cause yperkalemia in patients with end-stage renal failure. In contrast, ŕ-adrenergic blockade has been found to decrease the hyperkalemic effect of physical exercise in healthy subjects, although we were unable to confirm this effect in hemodialysis patients. In a crossover design, we studied the effect of carvedilol, a non-selective á-adrenergic blocker with an additional ŕ1-blocking activity, on exercise-induced hyperkalemia in 17 anuric hemodialysis patients. Methods: All subjects were hiven either carvedilol (25 mg/day) or placebo for 2 weeks in a random order with a 2-week wash-out period. At the end of each treatment period they underwent a 30-minute exercise test on a bicycle ergometer with a fixed load of 20 W. Results: The treatment with carvedilol caused a significant decrease in blood pressure. Serum potassium before exercise tests was similar (5.37 ń 0.2 and 5.24 ń 0.2 mmol/l on carvedilol and placebo, respectively; mean ń SE). During the exercise, serum postassium oncreased significantly (p 0.001 in both tests) and subsequently decreased during 30 minutes of recovery (p 0.05). The mean rate of potassium increment during the exercise was similar (23.3 ń 3.3 ćmol/min on carvedilol and 20.0 ń 3.6 ćmol/l/min on placebo). during recovery, the mean rate of potassium decrement was 5.0 ń 3.0 ćmol/l/min and 6.7 ń 2.7 ćmol/l/min, respectively. Serum sodium, ionized calcium, insulin and plasma renin activity were similar before the exercise tests and did not change during the exercise. Conclusion: Carvedilol does not enhance the hyperkalemic effect of moderate physical exercise in anuric hemodialysis patients.

141/2523

Tytuł oryginału: Expression of intercellular adhesion molecule-1 on the surface of peripheral blood and decidual lymhocytes of women with pregnancy-induced hypertension.
Autorzy: Wilczyński Jacek R., Banasik Małgorzata, Tchórzewski Henryk, Głowacka Ewa, Malinowski Andrzej, Szpakowski Marian, Lewkowicz Przemysław, Wieczorek Artur, Zeman Krzysztof, Wilczyński Jan
Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 102 (1) s.15-20, il., tab., bibliogr. 18 poz.
Sygnatura GBL: 305,582

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ciąża

in vitro

Streszczenie angielskie: Objective: If overexpression of intercelular adhesion molecule-1 (CD54) on lymphocytes exists it could have important implications for the pathophysiology of pregnancy-induced hypertension (PIH). Study design: CD54 "in vitro" expression (described as (p.c.) of CD54 + cells and CD54 mean fluorescence intensity, MFI) on the peripheral blood and decidual lymphocytes of pregnant with preeclampsia (PE) (n = 16), transient hypertension (TH) (n = 12), and controls (n = 9). Results: The percent (p.c.) of CD54 + peripheral blood lymphocytes, CD54 MFI on them and CD54 MFI on decidual lymphocytes were increased especially in PE. During PE the (p.c.) of CD54 decidual lymphocytes correlated negatively with platelet count. In TH the positive correlation between the blood pressure and the (p.c.) of CD54 peripheral blood lymphocytes as well as CD54 MFI on decidual lymphocytes were found. Conclusions: (1) PIH, especially PE, is accompanied by overexpression of intercellular adhesion molecule-1 (ICAM-1) on peripheral blood and decidual lymphocytes studied "in vitro", (2) Some of the parameters studied seem to correlate with clinical markers of PIH intensity but this fact needs further investigations using larger subject groups.

142/2523

Tytuł oryginału: A multicentre randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time.
Autorzy: Hliniak A., Gwiazdowska B., Szutkowski Z., Kraszewska E., Kukolowicz P., Jarząbski A., Sochacka B., Mazurkiewicz M., Paprota K., Oliskiewicz W., Zadrożna O., Milecki P., Kubiak M., Czopkiewicz L., Jagas M., Góźdź S., Wieczorek A., Woytowicz A., Cisowska B., Magdziarz H., Nowakowski S., Kośniewski W., Laskosz I., Serafin A., Gradoń E.
Źródło: Radiother. Oncol. 2002: 62 (1) s.1-10, il., tab., bibliogr. 13 poz.
Sygnatura GBL: 312,846

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Background and purpose: To compare in a phase III study the loco-regional control, disease-free survival and overall survival induced by an accelerated regimen (AF) as compared with conventional regimen (CF) and to analyze the early and late post-radiation morbidity in both arms. Materials and methods: Patietns with ó 75, WHO 0-1, suitable for a radical course of radiotherapy T1-T3, NO, MO, stage of glottic and supraglottic laryngeal cancer were randomized to either CF: 66Gy given in 33 fractions over 45 days or AF: 66Gy given in 33 fractions over 38 days (2 fractions every Thrusday). A total of 395 patients were included from 05.1995 to 12.1998. Results. Early toxicity: At the end of radiotherapy patietns treated with AF complained for more severe reactions than patients treated with CF. In 8 weeks after treatment completion patients treated with AF complained only for more severe pain on swallowing (P = 0.027). In 4 months after treatment completion all types of toxicity except for skin teleangiectasia (P = 0.001) were similar in the two groups. Locoregional control: comparison between CF and AF showed no difference in terms of loco-regional control (P = 0.37). Conclusions: The improvement in AF in terms of loco-regional control is estimated to be 3-5 p.c. in comparison with conventional regimen and is not significant. The intensity of reactions after 4 months was similar in both arms, what suggests the possibility of further shortening of the overall time by few days or enhancing the total dose within the limits of acceptable morbidity.

143/2523

Tytuł oryginału: The pathomechanism of posttraumatic edema of lower limbs. [P.] 1: The effect of extravasated blood, bone marrow cells, and bacterial colonization on tissues, lymphatics and lymph nodes.
Autorzy: Szczęsny Grzegorz, Olszewski Waldemar L.
Źródło: J. Trauma 2002: 52 (2) s.315-322, il., bibliogr. 31 poz.
Sygnatura GBL: 305,046

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

psy

in vitro

Streszczenie angielskie: Bacground: The mechanical injury of soft tissues and bones of lower extremities is frequently followed by long-lasting edema at the site of trauma and distally. The pathomechanisms of this complication remains unclear. Venous thrombosis and interruption of lymphatics are considered to be the main etiologic factors. We propose a concept that protracted healing of injured tissues and bones with involvement of the regional lymphatic system (lymphatics and nodes) is responsible for persistence of edema. The events affecting the first (scavenging) phase of healing of traumatized tissues, such as hematoma, translocation of bone marrow cells to soft tissues, and colonization by microorganisms, and in particular their effects on lymphatics and lymph nodes, were studied. Methods: Mongrel dogs weighing 15-20 kg were. Fresh blood or bone marrow cell (BMC) suspension was injected subcutaneously or intralymphatically into the paw. Strains of saprophyte bacteria residing on the skin surface were cultured and injected intradermally. Oilcontrast lymphography was performed before and after injections to evaluate the changes in lymphatics and nodes. Biopsy samples of paw skin, subcutaneous tissue, and regional lymph nodes (LN) were taken. The responsiveness of LN lymphocytes was studied in autologous mixed cultures with peripheral blood lymphocytes (PBL), BMC, and cultured bacteria. Results: The PBL from subcutaneously injected blood were evacuated by the lymphatic route at a rate of 1-3 proc./6 hr. There was no thrombosis of lymphatic vessels or obstruction of LN sinusoids...

144/2523

Tytuł oryginału: Long-term changes in calbindin D28K immunoreactivity in the rat hippocampus after cardiac arrest.
Autorzy: Sadowski Marcin, Lazarewicz Jerzy W., Jakubowska-Sadowska Katarzyna, Wiśniewski Henryk M., Mossakowski Mirosław J., Brown W. Ted
Źródło: Neurosci. Lett. 2002: 321 (1/2) s.90-94, il., bibliogr. 20 poz.
Sygnatura GBL: 305,936

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: Calbindin D28K (CB) expression was analyzed in the rat hippocampus following 10-min-cardiac arrest-induced ischemia within a year after reperfusion. In rats examined 3 days after ischemia, CB immunoreactivity disappeared completely from CA1 pyramidal neurons and from most CA2 pyramids. In the stratum granulosum of the dentate gyrus, mossy fibers, and hippocampal interneurons, CB immunoreactively was preserved, although staining was somewhat paler than that in control rats. A similar pattern of CB immunoreactively was found in rats sacrificed 14 days and 1 month after cardiac arrest. From the 14th postischemic day, neuronal loss in the stratum pyramidale of CA1 but not in that of CA2 became apparent. The reappearance of CB immunoreactivity in CA1 and CA2 pyramidal neurons was noticed 6 months after ischemia, and the pattern was identical to that observed in animals sacrificed 12 months after the octus. The prolonged loss and delayed reappearance of CB immunoreactivity in the hippocampus demonstrate that ischemia may induce long-term disturbances of protein expression, which may in turn result in impairment of hippocampal functioning.

145/2523

Tytuł oryginału: Induction of oxidative DNA damage by carcinogenic metals.
Autorzy: Bal Wojciech, Kasprzak Kazimierz S.
Źródło: Toxicol. Lett. 2002: 127 (1/3) s.55-62, bibliogr. s. 60-62
Sygnatura GBL: 306,158

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also include Co, Cu, Fe and Pt. A range of molecular mechanisms was proposed for these metals, reflecting their diverse chemical properties. The oxidative concept in metal carcinogenesis proposes that some complexes of the above metals (Co, Cr, Cu, Fe, Ni) formed in vivo undergo redox cycling, yielding reactive oxygen species and/or high valence metal ions which oxidize DNA. Some of the products of oxidative DNA damage, including 8-oxoguanine and strand breaks, induce mutations, which may lead to neoplastic transformation. The establishment of metal-binding modes in the cell nucleus and of their reactivity is crucial for the understanding of molecular events in metal carcinogenesis. We have proposed the binding sites for Ni(II) and Cu(II) in core histones (H3, H2A) and sperm protamines (HP2) and, using molecular models, provided evidence for the generation of promutagenic oxidative DNA damage by the bound metals.

146/2523

Tytuł oryginału: Recent advances in understanding of the molecular basis of anhidrotic ectodermal dysplasia: discovery of a ligand, ectodysplasin A and its two receptors.
Autorzy: Wiśniewski Sławomir A., Kobielak Agnieszka, Trzeciak Wisław H., Kobielak Krzysztof
Źródło: J. Appl. Genet. 2002: 43 (1) s.97-107, il., tab., bibliogr. (42) poz.
Sygnatura GBL: 305,055

Hasła klasyfikacyjne GBL:

dermatologia i wenerologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: Recent developments of the investigations on the molecular basis of anhidrotic ectodermal dysplasia are reviewed. Identification of the major product of the EDA gene (ectodysplasin A), a protein belonging to a group of TNF ligands, and molecular cloning of the cDNA, encoding its receptor (EDAR), a member of the RNF receptor family, are presented. The role of an alternative EDA receptor, localised on the X chromosome (XEDAR) in the development control of the differentiation of skin appendages, is discussed. Recent findings ave elucidated the cause of the autosomal forms of EDA, both dominant and recessive, and indicated an important role of a signal transduction pathway involving a protein product of the NEMO gene and the transcription factor NFkB in the differentiation of skin appendages.

147/2523

Tytuł oryginału: Transition C2718T in the AR gene, resulting in generation of a termination codon and truncated form of the androgen receptor, causes complete androgen insensitivity syndrome.
Autorzy: Ignacak Monika, Niedziela Marek, Trzeciak Wiesław H.
Źródło: J. Appl. Genet. 2002: 43 (1) s.109-114, il., tab., bibliogr. (14) poz.
Sygnatura GBL: 305,055

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The action of testosterone and 5ŕ-dihydrotestosterone are essentail to the development of the male phenotype. Patients with karyotype 46,XY, resistant to these hormones, exhibit a wide spectrum of phenotypes: from phenotypic female, through a range of incomplete masculinization, to under-virilized, infertile man. Theses disturbances are caused by mutations in the androgen receptor gene (AR). We studied a 46,XY fenotypic female with typical symptoms of Complete Androgen Insensitivity Syndrome (CAIS). Multiple temperature single-stranded confirmation polymorphism (MSSCP) an sequence analysis of exon 6 of the AR gene in a patient revealed a C2718T transistion causing R786X mutation in the loop between helices VII and VIII of the LBD of the androgen receptor. The R786X mutation has been described in a patient with CAIS only once and no such mutations have been described in Eastern Europe.

148/2523

Tytuł oryginału: Trisomy 8 mosaicism syndrome.
Autorzy: Wiśniewska Marzena, Mazurek Małgorzata
Źródło: J. Appl. Genet. 2002: 43 (1) s.115-118, il., bibliogr. (7) poz.
Sygnatura GBL: 305,055

Hasła klasyfikacyjne GBL:

genetyka

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Authors present the case of a 15-year-old boy assessed for Marfan syndrome for many years. The child was treated because of skeletal defects, mild mental deficiency and dysmorphic features of face. Chromosomal analysis showed a trisomy 8 mosaicism.

149/2523

Tytuł oryginału: Mirosław J. Mossakowski in memoriam [1929-2001].
Autorzy: Albrecht Jan
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.I-II, il.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

praca biograficzna

tytuł obcojęzyczny

Wskaźnik treści:

historia XX wieku

Temat osobowy:

Mossakowski

Mirosław Jan 1929-2001

150/2523

Tytuł oryginału: Proteolysis of endomorphin-1 by brain synaptic membrane-associated peptidases.
Autorzy: Wu Liming, Chen Junhui, Zhong Dulai, Lin Chentao, Wang Xingchang
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.1-5, il., bibliogr. [15] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: The biotransformation of endomorphin-1 (EM-1) by brain synaptic membranes has ben studied. Peptide fragments of EM-1 that were formed during incubation with membrane preparations in vitro were isolated by High-performance liquid chromatography (HPLC) and characterized using determination of amono acid composition. At pH 7.4, two degradation products, EM-1(1-3) and EM-1(1-2), were identified. EM-1 was degraded 77.5 p.c. at 30 min incubation with synaptic membranes. The time course of the experiments and the effect of carboxypeptidase inhibitor (CPI) demonstrated that the proteolysis reaction involves the participation of carboxypeptidase activity.

151/2523

Tytuł oryginału: The time course of the last contractions during incompletely fused tetani of motor units in rat skeletal muscle.
Autorzy: Celichowski Jan, Bichler Edyta
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.7-17, il., tab., bibliogr. [42] poz.
Sygnatura GBL: 302,090

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: The time course of the contraction and the relaxation of individual contractions during incompletely fused tetani of motor units were analyzed. Investigations were performed on fast fatigable (FF), fast resistant (FR) and slow (S) motor units of the rat medial gastrocnemius muscle. Stimulation of a motor unit with a series of nine trains of stimuli at a frequency from 10 to 150 Hz was used and tetani fused to a variable degree were recorded. For fast motor units the procedure was repeated twice and observations were made on potentiated tetani in the second series of stimulation. For each tetanus, the amplitude of the tension increase, the peak amplitude of the contraction, the contraction time and the half-relaxation time were measured in the last contraction of the tension recording. It was observed in all three types of motor units that the last contraction was prolonged in parallel with the increase of fusion of a tetanus. In this contraction, the contraction time slightly decreased whereas the half-relaxation time strongly prolonged. The prolongation of the half-relaxation time was the strongest in tetani of slow units. Moreover, for the last contraction in a tetanus, the rate of changes in tension were studied. The rate of increase in tension during the contraction decreased in parallel with the increase of fusion of a teatanus, whereas the maximal rate of the tension decrease during the relaxation was found in tetani with fusion indices of 0.79, 0.98 and 0.95 for FF, FR and S motor units, respectively. Changes in the time course of contractions in tetani to a variable degree can shed light on processes of summation of contractions in unfused tetani at the level of individual motor units.

152/2523

Tytuł oryginału: Superior laryngeal nerve section abolishes capsaicin evoked chemoreflex in anaesthetized rats.
Autorzy: Kaczyńska Katarzyna, Szereda-Przestaszewska Małgorzata
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.19-24, il., bibliogr. [21] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

neurologia

otorynolaryngologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

psychiatria i psychologia

szczury

Streszczenie angielskie: Respiratory effect of an intravenous injection of capsicin were investigated in nine vagotomized and subsequently laryngeally deafferentated, urethane- and chloralose- anaesthetized and spontaneously breathing rats. Bolus injection of capsaicin (5 ćg/kg) into the right femoral vein induced an expiratory apnoea of 4.23 ń 0.63 s duration (mean ń SEM). In post-apnoeic breathing, tidal volume increased by 14 p.c. from the control level (P 0.05) in all nine rats treated by vagotomy. Section of the superior laryngeal nerves (SLNs) precluded the occurrence of apnoea. Results of this study indicate that in vagotomized rats sensory input from the larynx constitute an important pathway to the nodose ganglia endowed with capsaicin receptors.

153/2523

Tytuł oryginału: Effects of social rearing conditions on conditioned suppression in rats.
Autorzy: Walasek Grażyna, Węsierska Małgorzata, Werka Tomasz
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.25-31, il., bibliogr. [34] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

psychiatria i psychologia

szczury

Streszczenie angielskie: mwenty-two rats were reared in standard conditions during the first two months of their life. Then the animals were divided into two groups exposed to different rearing conditions. Twelve animals (Group SO) were housed socially, six animals per cage, and for three weeks they were subjected to sensory stimulation in an enriched environment. The other ten subjects were kept individually (Group IN); one rat per mesh cage, in conditions of relatively impoverished sensory stimulation. In both groups the training of the conditioned emotional response (CER) was performed when animals were three months old. In contrast to IN subjects, the rats subjected to permanent social contacts and reared in the enriched environment (Group SO) revealed almost equally low instrumental response rates in trials with the conditioned stimulus (CS) paired with nociceptive foot-shock (US), and in period when no CS and/or US were applied. The results suggested that early exposure to an enriched environment caused a later decrease of the animals' capability to differentiate between the aversive CS and cues of the experimental context. This cognitive impairment was probably a secondary efffect of fear generalized to the entire experimental situation.

154/2523

Tytuł oryginału: Perception of facial affect in chronic schizophrenia and right brain damage.
Autorzy: Kucharska-Pietura Katarzyna, Klimkowski Marceli
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.33-43, il., tab., bibliogr. [52] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: This study was designed to compare the performance of 50 chronic schizophrenics (CS) to that of 30 right brain-damaged patients (R), and 50 healthy controls (N) on several facial perception measures: Emotion Labelling and Recognition, and the Benton Facial Recognition Test. CSs were diagnosed according to DSM-IV criteria and their psychiatric state was assessed using the PANSS scale. All subjects were right handed. Their cognitive state was assessed using the MMSE. Subjects rated their current mood on a visual analogue scale. The results showed that the CSn and Rs were significantly impaired compared to Ns for the emotional tasks but did not differ from each other. Moreover, the patient groups were significantly less accurate in recognising emotionally neutral facial stimuli. Each subject group had more difficulty processing negative relative to positive affect. The deficit in schizophrenia was found to be stable, which may reflect a trait-like, rather than a state-dependent, characteristic. Moreover, some support is provided for the notion that facial affect perception in chronic schizophrenia is associated with right hemisphere dysfunction.

155/2523

Tytuł oryginału: Hypoxic damage of the cerebellum in 7-day-old rats. Ultrastructural and histochemical study.
Autorzy: Dąmbska Maria, Gajkowska Barbara
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.45-49, il., bibliogr. [15] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: The damaging influence of hypoxia on the cerebellum in immature rats, which is still discussed, was investigated. Using material obtained in a modified Levine model for combined hypoxic-ischemic damage in 7-day-old rats, we examined changes in cerebellum submitted to hypoxia only. The results demonstrated classic features of hypoxic nervous tissue damage and calcium accumulation in mitochondria and endoplasmic reticulum. This was investigated using electron microscopy combined with the oxalate-pyroantimonate method. We propose that Caý+ increases in endoplasmic reticulum and mitochondrial Caý+ pools may be involved in damage-mediated mechanisms. These results support a role of calcium as a mechanism of cerebellar cell loss after this form of injury.

156/2523

Tytuł oryginału: Centrally applied vasopressin prevents posthemorrhagic hypotension in WKY rats.
Autorzy: Ufnal Marcin, Żera Tymoteusz
Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.51, il.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

badanie porównawcze

tytuł obcojęzyczny

Wskaźnik treści:

157/2523

Tytuł oryginału: Serum concentrations of markers of type I collagen metabolism in women taking monophasic oral contraceptives.
Autorzy: Rechberger Tomasz, Baranowski Włodzimierz, Bogusiewicz Michał, Postawski Krzysztof, Jakimiuk Artur J., Tomaszewski Jacek, Kulik-Rechberger Beata, Jakowicki Jerzy A.
Źródło: Ginekol. Pol. 2002: 73 (2) s.81-86, il., tab., bibliogr. 21 poz., streszcz.
Sygnatura GBL: 301,184

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: Karboksyterminalny propeptyd kolagenu typu I (PICP-carboxy-terminal propeptide of type I procollagen) i stabilizowany pirydynoliną karoboksyterminalny telopeptyd kolagenu typu I (ICTP - cross-linked carboxy-terminal telopeptide of type I collagen) są markerami odpowiednio rozpadu i synetzy kolagenu typu I. Ich stężenia w surowicy krwi odzwierciedlają tempo przemian tego białka w organizmie. Oznaczono stężenia PICP i ICTP w surowicy kobiet przyjmujących doustne środki antykoncepcyjne zawierające 20 ćg etinylestradiolu i 150 ćg desogestrelu (Mercilon) lub 30 ćg etinylestradiolu i 150ćg desogestrelu (Marvelon) przez 6 miesięcy. Stwierdzono znamiennie niższe średnie stężenie PICP po 3 miesiącach przyjmowania preparatu zawierającego 20 ćg etinylestradiolu i 150 ćg desogestrelu, które jednak po 6 miesiącach nie różniło się istotnie od wartości poczatkowej. U kobiet przyjmujących preparat zawierający 30 ćg etinylestradiolu i 150 ćg desogestrelu nie zaobserwowano znaczących zmian stężenia PICP. Średnie stężenia ICTP nie uległy istotnym zmianom w obu grupach. Wyniki wskazują na przemijające zmniejszenie syntezy kolagenu typu I u kobiet przyjmujących środki antykoncepcyjne zawierające 20 ćg etinylestradiolu. Żaden z obu badanych preparatów nie wpływa znacząco na degradację kolagenu typu I w organizmie kobiet podczas pierwszych sześciu miesięcy przyjmowania.

Streszczenie angielskie: Objectives: To investigate serum concentrations of the carboxy-terminal of type I procollagen (PICP) and cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), reflecting the rate of synthesis and degradation of the parent collagen respectively, in women using monophasic oral contraceptives. Study design: PICP and ICTP were estimated in 60 women taking 20 ćg of ethinyl estradiol (EE) + 150 ćg of desogestrel (DSG) or 30 ćg of EE + 150 ćg DSG over six months. Results: Mean PICP concentration decreased in women receiving 20 ćg of EE + 150 ćg of DSG after three cycles of administration. However, after six months this value returned to a leel comparable to the initial one. In women taking 30 ćg of EE + 150 ćg of DSG the mean concentrations of PICP did not change significantly throughout the period studied. None of the oral contraceptives noticeably influenced the concentrations of ICTP. Conclusion: Investigated oral contraceptives do not significantly affect the metabolism of type I collagen, however a transient decrease in its biosynthesis may be expected during the use of formulations containing 20 ćg of EE.

158/2523

Tytuł oryginału: Evaluation of the antisperm antibodies in infertile couples afflicted with a cervical factor.
Autorzy: Rogoza Andrzej, Łukaszuk Krzysztof, Mielcarek Piotr
Źródło: Ginekol. Pol. 2002: 73 (2) s.87-92, il., bibliogr. 11 poz., streszcz.
Sygnatura GBL: 301,184

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: Dokonano oceny metod stosowanych w wykrywaniu przeciwciał przeciwplemnikowych w diagnostyce niepłodności immunologicznej. Materiał stanowiło 38 par leczonych w II Klinice Położnictwa i Ginekologii AMG z powodu podejrzenia niepłodności immunologicznej. Na podstawie przeprowadzonych badań stwierdzono małą przydatność diagnostyczną lateksowego testu aglutynacji. Jako podstawową metodę wykrywania przeciwciał przeciwplemnikowych proponujemy metodę Western blottingu.

Streszczenie angielskie: Objectives: The purpose of this study was to evaluate methods used for antisperm antibodies detection in infertility. Methods: The studied cohort comprised 38 infertile couples with a distinct cervical factor. Presence of antisperm antibodies and their levels in circulation were evaluated in sera samples of both partners and also in the cervical mucus and semen with the Latex Agglutination test. Western Blotting was applied as an additional method in antibody detection. We also assessed: the number of sexual partners, potentially allergizing sexual behaviour and other potentially sensitising factors. Results: The positive antisperm antibodies were detected merely twice and only in one case there was evidence of insemination-impeding antisperm humoral response. The Western Blotting method enabled us to obtain a reaction to a range of sperm proteins which reaction to a range of sperm protein which reacted with antibodies both in serum and in seminal plasma. Conclucions: Determination of infertility on immunological grounds on the basis of a single determinant on sperm presents little diagnostic value. In our view, the combination of patient's clinical status with immune-system response to a spectrum of sperm antigens provides means of infertility evaluation. We propose Western Blotting as an useful technique for detection of antisperm antibodies.

159/2523

Tytuł oryginału: Novye struktury 0-cpecificheskikh polisakharidov bakterijj roda Proteus. 2: Polisakharidy, soderzhashhie O-acetilnye gruppy.
Tytuł angielski: New structures of the O-specific polysaccharides of Proteus. [P.] 2: Polysaccharides containing O-acetyl groups.
Autorzy: Kondakova A. N., Toukach F. V., Senchenkova S. N., Arbatsky N. P., Shashkov A. S., Knirel Y. Ju., Zych K., Torzewska A., Rożalski A., Kołodziejska K., Sidorczyk Z.
Źródło: Biokhimija 2002: 67 (2) s.240-252, il., tab., bibliogr. 36 poz., sum.

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: Structures of five new O-specific polysaccharides of the lipopolysaccharides of bacteria Proteus were established. Four of them, Proteus penneri 4 (072), Proteus vulgaris 63/57 (037), Proteus mirabilis TG 277 (069), and Proteus penneri 20 (017), contain O-acetyl groups in non-stoichiometric quantities, and the polysaccharide of P. penneri 1 st structuraly related to that of P. penneri 4. The structures were elucidated using NMR spectroscopy, including one-dimensional 1H nd 13C NMR, two-dimensional 1H, 1H correlation (COSY, TOCSY), 1H, 13C heteronuclear multiple-quantum coherence (HMQC) and multiple-bond correlation spectroscopy, as well as nuclear Overhauser effect spectroscopy (NOESY or ROESY), along with chemical methods. The structural data obtained are useful as the chemical basis for the creation of the classification scheme for Proteus strains.

160/2523

Tytuł oryginału: Novye struktury O-specificheskikh polisakharidov bakterijj roda Proteus. 1: Fosfatsoderzhashhie polisakharidy.
Tytuł angielski: New structures of the O-specific polysacchardies of Proteus. [P.] 1: Phosphate-containing polysaccharides.
Autorzy: Toukach F. V., Kondakova A. N., Arbatsky N. P., Senchenkova S. N., Shashkov A. S., Knirel Y. A., Zych K., Rożalski A., Sidorczyk Z.
Źródło: Biokhimija 2002: 67 (2) s.318-331, il., tab., bibliogr. 23 poz., sum.

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The O-specific polysaccharide chains (O-antigens) of the lipopolysacchardides of five Proteus strains, P. vulgaris 017, P. mirabilis 016 and 033, and P. penneri 31 and 103, were found to contain phosphate groups that link the non-sugar components, namely, ethanolamine and ribitol. From them, the polysaccharides of P. mirabilis 016 and P. penneri 103 include ribitol phosphate in the main chain and thus resemble ribitol teichoic acids of Gram-positive bacteria. The structures of the polysaccharides were elucidated using NMR spectroscopy, including two-dimensional 1H, 1H correlation spectroscopy (COSY and TOCSY), nuclear Overhauser effect spectroscopy (NOESY or ROESY), and H-detected 1H, 13C, and 1H, 31P heteronuclear multiple-quantum coherence (HMQC), along with chemical methods. The structures determined are unique among the bacterial polysaccharides and, together with data obtained earlier, represent the chemical basic for classification of Proteus strains. Based on structural similarities of the O-specific polysaccharides and serological relationships between the O-antigens, we propose to add P. penneri strain 31 to serogroup 019 and to extend serogroup 017 by including P. penneri strain 16.

161/2523

Tytuł oryginału: Further studies on the anti-oxidative effect of putrescine in sodium nitrite-treated rats.
Tytuł polski: Dalsze badania nad antyoksydacyjnym wpływem putrescyny u szczurów zatruwanych azotynem sodowym.
Autorzy: Grudziński Ireneusz P., Frankiewicz-Jóźko Anna
Źródło: Rocz. Państ. Zakł. Hig. 2002: 53 (1) s.11-17, il., bibliogr. 30 poz., streszcz.
Sygnatura GBL: 301,906

Hasła klasyfikacyjne GBL:

toksykologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie polskie: Badano antyoksydacyjne właściwości putrescyny (10 mg/kg m.c./dzień) u szczurów zatruwanych per os azotynem sodowym (10 mg NaNO2/kg m.c./dzień) przez okres 14 dni. Putrescynę podawano per os w 3-4 godz. po podaniu azotynu i/lub 0,9 p.c. NaCl (kontrola) przez okres 7 dni (dzień 7-14). Azotyn sodowy zwiększył poziom substancji reagujących z kwasem tiobarbiturowym (TBARS) w błonie śluzowej jelita cienkiego i wątrobie, nie wpływając na zmiany tego parametru we krwi szczurów. Nie wykazano, aby u zwierząt zatruwanych azotynem dochodziło do zmian zarówno stanu antyoksydacyjnego surowicy (TAS) oraz aktywności dysmutazy ponadtlenkowej (SOD) we krwi, wątrobie czy błonie śluzowej jelita cienkiego. Podawanie szczurom putrescyny zmniejszyło poziom TBARS w badanych tkankach przy zwiększonym poziomie TAS w surowicy. Putrescyna znacząco obniżyła aktywność SOD w wątrobie i krwi i nie zmnieniając aktywności tego enzymu w jelicie cienkim. Rezultaty badań sugerują, że podawanie putrescyny per os szczurom może prowadzić do obniżenia peroksydacji lipidowej indukowanej azotynem sodowym.

Streszczenie angielskie: Studies were carried out to elucidate the anti-oxidative effect(s) of putrescine (10 mg/kg b.w./day) in rats treated per os with either sodium nitrite (10 mg/kg b.w./day) or normal saline (control) for 14 days. The putrescine was given to rats for 7 days only (days 7-14) and it was introduced 3-4 hrs after nitrite or saline dosage. Sodium nitrite increased thiobarbituric acid reactive substances (TBARS) in rat small intestinal mucosa and liver, and the agent did not have any effect on the total anti-oxidant status (TAS) and lipid peroxidation of rat blood. Nitrite did not also change the activity of superoxide dismutase (SOD) in the small intestinal mucosa, liver and blood, as well. Pretreatment of nitrite-treated rats with putrescine decreased TBARS and increased TAS in animals. Putrescine decreased SOD activity in the blood and liver of nitrite- and/or saline-treated rats, however, the agent did not affect the SOD enzyme in the small intestinal mucosa. Results suggest that putrescine dosed to nitrite-treated rats possesses some anti-oxidative properties.

162/2523

Tytuł oryginału: A pilot study on the histochemical evaluation of Na/K-ATPase and succinate dehydrogenase in rat intestinal villi.
Tytuł polski: Badania pilotowe nad histochemiczną oceną ATPazy-Na/K oraz dehydrogenazy bursztynianowej w kosmkach jelita cienkiego szczura.
Autorzy: Grudziński Ireneusz P.
Źródło: Rocz. Państ. Zakł. Hig. 2002: 53 (1) s.19-26, il., bibliogr. 31 poz., streszcz.
Sygnatura GBL: 301,906

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie polskie: Badano wpływ zatrucia azotynem sodowym na aktywność ATPazy-Na/K oraz dehydrogenazy bursztynianowej (SDH) w błonie śluzowej jelita cienkiego szczurów. Zwierzęta otrzymywały per os wodny roztwór azotynu sodowego (10 mg NaNO2/kg m.c.) i/lub 0,9 proc. roztwór chlorku sodowego (kontrola) przez okres 3 i 12 tygodni. Histoenzymatyczna analiza wykazała azotynowe obniżenie aktywności ATPazy-Na/K oraz SDH w kosmkach jelitowych ze szczególnym nasileniem wpływu azotynu w 12 tygodniu zatrucia zwierząt.

Streszczenie angielskie: Effects of poisoning with sodium nitrite on Na/K-ATPase and succinate dehydrogenase (SDH) activity were examined in the small intestine mucosa of male Wistar rats. The animals were treated per os with either an aqueous solution of sodium nitrite (10 mg NaNO2/kg b.w.) or normal saline (control) daily for 3 or 12 weeks. Histochemical analyses show that sodium nitrite decreased Na/K-ATPase and SDH in rat intestinal villi, and the nitrite side effect(s) was mainly observed in animals treated for 12 weeks.

163/2523

Tytuł oryginału: CD45 in memory and disease.
Autorzy: Tchilian Elma Z., Beverley Peter C. L.
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.85-93, il., bibliogr. 72 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: CD45 (the leukocyte common antigen) is known to function as a tyrosine phosphatase in leukocyte signaling. Biochemical studies indicate that CD45 is involved in the regulation both of T cell receptor-associated kinases and Janus kinases that transmit signals from cytokine receptors. However, the function of the different isoforms of CD45 generated by complex alternative splicing, and indeed the role of the whole extracellular domain of the molecule, remain mysterious. Analysis of CD45 knock-outs and of trangenic mice expressing single CD45 isoforms, as well as the disease associations of human polymorphisms, is providing new insights into CD45 function. Accumulating data from these genetic and biochemical studies promises to elucidate the role of high and low molecular weight isoforms of CD45 in the function of naive and memory T lymphocytes.

164/2523

Tytuł oryginału: Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.
Autorzy: Bottini Nunzio, Bottini Egidio, Gloria-Bottini Fulvia, Mustelin Tomas
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.95-104, tab., bibliogr., 80 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

genetyka

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: A major challenge in the post-genomic era is to identify the physiological functions of genes and elucidate the molecular basis for human disease. Genetic polymorphisms offer a convenient avenue for these efforts by providing evidence for the involvement of a given gene in human pathophysiology. Here we review the current evidence linking the low-molecular weight protein tyrosine phosphatase (LMPTP) to several common diseases, including allergy, asthma, obesity, myocardial hypertrophy, and Alzheimer's disease. Based on the known effects of the genetic polymorphisms on the alternative mRNA splicing and enzyme levels of LMPTP, we discuss the possible molecular mechanisms of LMPTP ivolvement in these diseases.

165/2523

Tytuł oryginału: Archivum Immunologiae et Therapiae Experimentalis!
Tytuł angielski: Significance of tumor-cell receptors in human cancer.
Autorzy: Żeromski Jan
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.105-110, il., bibliogr. 48 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Every tumor cell is equipped with an array of biologically active surface molecules, and several of these function as receptors for various ligands. They include MHC, or in the case of humans, HLA antigens, cytokine receptors, cell-adhesion molecules, growth factor receptors, Fas/Fas-ligand molecules and others. Their expressions are a subject to alternations, usually to the advantage of tumor growth and spread. Some appear on tumor cells de novo, having no counterparts on the respective normal cells. Detailed knowledge about the expression of tumor-cell receptors and their genotypes, in particular of cancerous ones, may provide information essential for the creation of tools for specific tumor immunotherapy.

166/2523

Tytuł oryginału: Potential for immune reconstitution through G-CSF treatment of HIV patients.
Autorzy: Aulock Sonja von, Hartung Thomas
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.111-120, il., bibliogr. 90 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

aIDS

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: New treatment strategies for HIV/AIDS are very successful in reducing viral load. However, reconstitution of the immune system takes about one year and may be insufficient or remain incomplete. During this time the patient remains prone to opportunistic infections as a result of the complex immune dysfunction caused by the virus. Recombinant granulocyte colony-stimulating factor (G-CSF) has diverse immunomodulatory properties which may be beneficial in aiding immune reconstitution.

167/2523

Tytuł oryginału: GM-CSF regulation in eosinophils.
Autorzy: Esnault Stphane, Malter James S.
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.121-130, bibliogr. 113 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizingits coding mRNA.

168/2523

Tytuł oryginału: Immunomodulation of macrophages by pathogenic Yersinia species.
Autorzy: Ruckdeschel Klaus
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.131-137, il., bibliogr. 37 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: The interaction between macrophages and bacterial pathogens plays a crucial role in the pathogenesis of infectious diseases. Pathogenic species of the Gram-negative bacterium Yersinia deploy complex strategies to disarm macrophages and to disrupt their response to infection. For this purpose, Yersinia sp. engage a type III protein secretion system that mediates the polarized translocation of Yersinia virulence factors, the so-called Yops (Yersinia outer proteins), into the host cell cytoplasm. There, the Yops act on different cellular levels to neutralize a sequence of programmed phagocyte effector functions. Yersiniae initially impair the phagocytic machinery and block the generation of th ebacterial oxidative burst. Furthermore, yersiniae uncouple an array of fine-tuned signals of innate immunity, which leads to suppression of macro\hage TNF-ŕ production and to macrophage apoptosis. The impairment of cellular functions results in a scenario by which Yersinia efficiently resists the attack of the macrophage and finally kills the macrophage by activating its intrinsic cell suicide mechanism. This review highlights the aspects of Yersinia-macrophage interaction that determine the fate of the infected cell.

169/2523

Tytuł oryginału: Effect of IL-18 on IL-1á and sIL-1RII production.
Autorzy: Jabłońska Ewa, Iżycka Aneta, Wawrusiewicz Natalia
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.139-141, il., bibliogr. 7 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: In the present study we investigated the effect of interleukin 18 (IL-18) on th e production of IL-1ánd soluble IL-1 receptor II (sIL-1RII) by human neutrophils. The results obtained indicate that recombinant human IL-18 (rhIL-18) induces IL-1á and, to a lesser extent, sIL-1RII production by human neutrophil isolated from peripheral blood. However, this effect was less important than lipopolysaccharide (LPS) stimulation. Additionally, our observations suggest that IL-18 can induce priming of neutrophils for IL-1á and, to a lesser extent, sIL-1RII production by LPS-stimulated cells. The ability of IL-18 to serve as an effective modulator for IL-1áand its regulatory protein may have sigificance in the inflammatory and immune reactions mediated by IL-1á.

170/2523

Tytuł oryginału: A study of thyroglobulin concentration in the thyroid and serum of patients with different thyroid disorders.
Autorzy: Czarnywojtek Agata, Krysińska Iwona, Łącka Katarzyna, Stawny Bolesław, Rólski Michał, Jarząb Barbara, Włoch Jan, Gembicki Maciej
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.143-148, il., tab., bibliogr. 19 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Knowledge concerning the structure and quality of thyroglobulin (tg) has great significance for the better understanding of the pathogenesis of different thyroid diseases. The localization of the Tg gene and studies of its structure by molecular biological techniques make possible precise investigations of its expression. The aim of our study was to evaluate Tg content in the thyroids and Tg concentrations in the serum of 108 patients suffering from beenign or malignant thyroid disorders. The method of investigation was isolating total protein from thyroid tissues obtained during surgery and determining Tg content in the thyroid extracts and Tg concentrations in serum The Tg concentrations in serum and in thyroid protein extracts were evaluated by fluoroimmunometric assay. Statisctical analysis was carried out with the help of the computing programmes.

171/2523

Tytuł oryginału: Single photon emission tomography in radioimmune imaging of diabetic foot infection.
Autorzy: Bohchelian H. A., Klisarova A. D., Koeva L. A.
Źródło: Diabetol. Pol. 2002: 9 (1) s.39-44, il., tab., bibliogr. 24 poz., sum.
Sygnatura GBL: 313,197

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

psychiatria i psychologia

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The aim of our study was to evaluate the clinical efficacy of single photon emission computer tompgraphy (SPECT) in combination with planar radioimmune and methylene-diphosphonate (MDP) - scintigraphic imaging of diabetic foot infection. The study group comprised 32 patients with type 1 and type 2 diabetes mellitus. All patients had diabetic foot ulceration with possible infection. All patients underwent clinical, bacteriological, X-ray and radioisotopic examination. Biochemical and instrumental investigation was carried out to estimate the degree of glycaemic control and available chronic diabetic complications. X-ray examination included radiographs centered on the foot lesion. All patients underwent bone scintigraphy with 370 MBq Technetium-99m-MDP (Tc-99m-MDP) three hours after injection in 3 projections (AP; LAO; RAO). Radioimmune planar imaging was performed by immunoscintigraphy with Tc-99m conjugated with monoclonal antigranulocyte antibody (MAB) BW 250/183. Immunoscintigraphy was performed 4 and 24 hours after administration of 740 MBq Tc-99m-MAB BW 250/183. In positive planar immunoscintigraphic cases and necessity of precise localization of inflammatory process - single photon emission computer tomography was performed. Final diagnosis - osteomyelitis was verified by bacteriological cultures and a long term follow up. Twenty two true positive cases, eight true negative cases, one false positive case, one false negative case were established. The sensitivity of the applied method for detection of osteomyelitis was 94 p.c., specificity 92 p.c., diagnostic accracy 93 p.c...

172/2523

Tytuł oryginału: Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit.
Autorzy: Pak Jonathan T., Green John T., Heifets Boris, Pak Michelle H., Woodruff-Pak Diana S.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR105-BR112, il., bibliogr. 27 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

króliki

płeć żeńska

Streszczenie angielskie: The cognition-enhancing drug, nefiracetam, is in Phase III clinical trials to treate memory impairment in Alzheimer's disease (AD). Nefiracetam ameliorates acquisition of delay eyeblink classical conditioning in older rabbits, a form of associative learning with striking behavioral and neurobiological similarities in rabbits and humans. In both species, delay eyeblink conditioning engages the septo-hippocampal cholinergic system and is disrupted when the cholinergic system is antagonized. Delay eyeblink classical conditioning is impaired in normal aging and severely disrupted in AD. To test further the efficacy of nefiracetam in an animal model that mimics some of the neurobiological and behavioral effects present in AD, we tested 56 older rabbits assigned to 7 treatment groups in the 750 ms delay eyeblink conditioning procedure. Older rabbits were injected with 1.5 mg/kg scopolamine to simulate disrutpion of the cholinergic system in AD. Three doses of nefiracetam (5, 10, or 15 mg/kg) were also injected in older rabbits receiving 1.5 mg/kg scopolamine. Control groups were treated with 1.5 mg/kg scopolamine + vehicle, wehicle alone, or explicitly unpaired presentations of conditioning stimuli and vehicle or 1.5 mg/kg scopolamine + 15 mg/kg nefiracetam. Rabbits injected with 1.5 mg/kg scopolamine alone were impaired, but a dose of 15 mg/kg nefiracetam reversed significantly the behavioral impairment. Nefiracetam had ameliorating effects on a task impaired in AD in an animal model of AD: older rabbits with cholinergic system antagonism.

173/2523

Tytuł oryginału: Percutaneous implantation of a biological valve in the aorta to treat aortic valve insufficiency - a sheep study.
Autorzy: Boudjemline Younes, Bonnet Damien, Sidi Daniel, Bonhoeffer Philipp
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR113-BR116, il., bibliogr. 14 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: Historically, the surgical implantation of a mechanical valve in the descending aorta permitted the reduction of regurgitant flow in chronic aortic insufficiency. Long term clinical results were excellent but with the development of the pump oxygenators, orthotopic valvar replacement has become the conventional treatment of aortic valve diseases. We wanted to reconsider the ectopic position in sheep using a new percutaneous technique. A biological valve harvested from a bovine jugular vein was sutured into a vascular stent. After the creation of a severe aortic insufficiency, the valved stent was percutaneously implanted according to standard stent placement techniques. Hemodynamic and angiographic evaluations were carried out during the procedure; finally, anatomic evaluation was performed. A severe aortic insufficiency was created in all animals (9/9). 3 had a single stent in the descending aorta and 3 had an addtional stent in the brachiocephalic trunk. A control group of 3 animals had no valve implantation. One sheep had an additional valve implant because one overdilated stent had become insufficient. Early evaluation of the implanted valve function confirmed the perfect competence of 9 out of 10 valved stents. However, for unknown reasons all the animals died within 24 hours after the procedure. Percutaneously implanted valves in the thoracic aorta of sheep with massive aortic insufficiency function well in the acute study. In comparison to previous surgical results, this technique might become an alternative to surgery in patients with chronic aortic insufficiency in whom perioperative risks are high.

174/2523

Tytuł oryginału: Serodiagnostic and immunoprophylactic potential of a 78kDa protein of Leishmania donovani of Indian origin.
Autorzy: Mukherjee Mandira, Bhattacharyya Anindita, Duttagupta Swadesh
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR117-BR122, il., tab., bibliogr. 35 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: The serodiagnosis of visceral leishmaniasis due to Leishmania donovani using crude parasite antigen is complicated in many endemic areas by cross-reactions with serum from humans infected with other protozoan diseases. The search for pure antigens avoiding such cross-reactions is in progress. Developing a vaccine against cutaneous leishmaniasis has been much more successful than against visceral leishmaniasis. Immunoprophylactic studies using various combinations of antigens and adjuvants are also in progress, and several strategies are in use, with varying degrees of success. Promastigotes of Leishmania donovani were used. The 78kDa protein was purified by a monoclonal antibody tagged GNBr sepharose CL-4B column. The presence of the protein in both stages of the parasite and in kala-azar patient serum was analyzed by western blotting. ELISA was used for serodiagnosis and isotype analysis of antibodies produced in immunized mice. Immunoprophylactic studies were carried out based on in vitro transformation of amastigotes to promastigotes. The 78 kDa membrane protein, present in both amastigote and promastigote forms of the parasite, was purified to homogeneity. The protein was found to have serodiagnostic potential to detect kala-azar. BALB/c mice immunized with 78kDa protein revealed reduction in spleen parasitemia. Isotype profiles of antibodies produced by immunized mice showed increased production of IgG2a and decreased IgG levels. Our results demonstrated, for the first time, the serodiagnostic and immunoprophylactic use of a pure membrane protein isolated from Leishmania donovani of Indian origin...

175/2523

Tytuł oryginału: Functional maps of the junctions between interglobular contacts and active sites in glycolytic enzymes - a comparative analysis of the biochemical and structural data.
Autorzy: Torshin Ivan Y.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR123-BR135, il., tab., bibliogr. 47 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: Oligomers and separate subunits of the glycolytic enzymes often have different catalytic properties. However, spectral data show an apparent lack of significant conformational changes during oligomerization. Since the conformation of an enzyme determines its catalytic properties, the structural mechanism(s) influencing the activity is of considerable interest. Analysis of the spatial structures of the junctions between interglobular contacts and binding sites may give a clue to the mechanism(s) of the activation. In this work, the problem was studied using available structural and biochemical data for the oligomeric enzymes of glycolysis. Computational analysis of the structures of the junctions has identified three structurally distinct types of junctions: 1. interglobular binding site (2 of 8 enzymes); 2. domain-domain stabilization (5 of 8); and 3. 'sequence overlap' or a local conformational change (all enzymes). Thus the catalytic activity may be influenced through the shifts of the modules of protein structure (types 1,2) and/or due to a slight change in the local structure (type 3). The more common junctions of types 2 and 3 are well conserved among eukaryotic enzymes, which suggests their biological importance. The results suggest that a profound and a complex change in conformation in subunits of an oligomeric enzyme may not be necessary for a significant change in the catalytic properties. The analysis maps the residues important for the junctions and thus for the link between the catalytic activity and the oligomeric state of the enzymes.

176/2523

Tytuł oryginału: Intracerebroventricular administration of bacterial lipopolysaccharide prevents the development of acute experimental pancreatitis in the rat.
Autorzy: Jaworek Jolanta, Bonior Joanna, Nawrot Katarzyna, Leja Anna, Sendur Ryszard, Stachura Jerzy, Pawlik Wiesław, Konturek Stanisław
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR136-BR143, il., tab., bibliogr. 46 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: Lipopolysaccharides (LPS) are responsible for septic shock but low doses of LPS reduce pancreatic damage produced by caerulein-induced pancreatitis (CIP) in rats. Leptin, produced by adipocytes attenuates the severity of CIP. The aim of this study was to evaluate the effect of intracerebroventricular (i.c.v) administration of LPS on CIP and plasma leptin level and to investigate the involvement of sensory nerves (SN) in the effects of LPS on CIP. CIP was produced by subcutaneous (s.c.) infusion of caerulein (25 ćg/kg) to conscious rats. SN were deactivated with capsaicin (100 mg/kg s.c.). LPS (0.2, 2, or 20 ćg/rat) were applied to the right cerebral ventricle 30 min prior to CIP. CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an antiinflammatory interleukin 10 (IL-10), (by 400 p.c., 1000 p.c., 700 p.c. and 50 p.c., respectively), confirmed by histological examination and accompanied by 40 p.c. reduction in pancreatic blood flow. Pretreatment of CIP rats with i.c.v. LPS resulted in significant reduction of CIP accompanied by dose-dependent increase in plasma levels of leptin and IL-10. Deactivation of SN, which by itself failed to affect CIP, completely reversed the beneficial effects of i.c.v. administration of LPS on CIP and reduced plasma leptin and IL-10 concentrations. Pretreatment with LPS given i.c.v. prevents the development of caerulein-induced pancreatitis through the activation of SN and though the release of leptin.

177/2523

Tytuł oryginału: Fibrinogen and smooth muscle cell detection in atherosclerotic plaques from stable and unstable angina - an immunohistochemical study.
Autorzy: Loukas Marios, Dąbrowski Marek, Wagner Teresa, Walczak Ewa, Witkowski Andrzej, Rużyłło Witold
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR144-BR148, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: This study presents a systematic analysis of atherothrombotic lesions taken by percutaneous atherectomy and post mortem examination from coronary arteries, in order to identify: a) the topographic occurrence of fibrinogen and smooth muscle cells (SMCs), b) their independent expression in stable and unstable plaques, and c) their co-expression, which can provide a better understanding of the involvement of fibrinogen and SMCs in the development and progression of atherosclerotic plaques. Material/Methods: 120 specimens from atherosclerotic lesions were collected, using directional coronary atherectomy; 40 additional specimens were collected from postmortem examinations. All specimens were stained by immunohistochemical methods with monoclonal and polyclonal antibodies (DAKO) for fibrinogen and SMCs. Results: Fibrinogen appeared to be a component of all stable and unstable coronary atherosclerotic plaques, with a significant predominance in unstable angina. No significant difference was observed between SMC-stained areas in stable and unstable angina; however, a significant difference exists in co-expression of SMCs and fibrinogen between unstable and stable angina. Interestingly, the total number of SMCs at the first stages of formation of unstable plaques is less than in stable plaques. However, in a number of advanced coronary atherosclerotic plaques associated with unstable angina, we observed an increasingly progressive inflammatory cell activity, in which SMC areas were sifnigicantly increased...

178/2523

Tytuł oryginału: Effects of acute hypoxemia/ischemia on EEG and evoked responses at normothermia and hypothermia in humans.
Autorzy: Stecker Mark M., Escherich Alison, Patterson Terry, Bavaria Joseph E., Cheung Albert T.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR223-CR228, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Hypothermia is used clinically to prevent neurologic injury but the degree of protection which it affords at various levels of the nervous system in humans is difficult to establish. Material/Methods: The temporal changes in EEG amplitude and somatosensory evoked potential (SEP) amplitudes in a patient experiencing acute normothermic hypoxemia, a patient experiencing acute circulatory arrest at moderate hypothermia and a collection of patients undergoing deep hypothermic circulatory arrest were analyzed to determine the rate at which changes occur during acute lack of oxygen delivery at various temperatures. Results: In each case, it was found that more rostrally geneated potentials disappeared more quickly than more peripheral potentials. All potentials decayed more slowly during acute normothermic hypoxemia than during circualtory arrest. During circulatory arrest at 14.4řC, the amplitude of the Erb's point, 13 and N18 potentials in th SEP took 5 times longer to drop to 50 p.c. of their value at the onset of ischemia than with circulatory arrest at 30.9řC. Conclusions: The longer times to disappearance of the SEP potentials during deep hypothermia compared to moderate hypotheramia was consistent with the predicted 3.5 - 6.5 fold reduction in metabolic activity at deep hypothermia compared to moderate hypothermia. The prolonged time to disappearance of the SEP during normothermic hypoxemia demonstrates that even with reduced oxygen delivery the continued delivery of metabolic substrate can be critical to neural function.

179/2523

Tytuł oryginału: Protocol for rapid sequence intubation in pediatric patients - a four-year study.
Autorzy: Marvez-Valls Eduardo, Houry Debra, Ernst Amy A., Weiss Steven J., Killeen James
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR229-CR234, tab., bibliogr. 9 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

pediatria

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Background: The purpose of the study was to evaluate a protocol for rapid sequence intubation (RSI) for pediatric patients in a Level 1 trauma center. Material/Methods: Retrospective review of prospectively gathered Continuing Quality Improvement (CQI) data at an inner city Level 1 trauma center with an emergency medicine residency program. Protocols for RSI were established prior toinitiating the study. All pediatric intubations at the center from February 1996 to February 2000 were included. Statistical analysis included descriptive statistics for categorical data and Chi-square for comparisons between groups. Results: Over the 4-year study period there were 83 pediatric intubations ranging in age from 18 months to 17 years; mean age 8.6. All had data collected at the time of intubation. There were 20 (24 p.c.) females and 62 (76 p.c.) males (p 0.001). Resons for intubation were related to trauma in 71 (86 p.c.) and medical reasons in 12 (14 p.c.) (p 0.001). Of the trauma intubations 7 (10 p.c.) were for gunshot wounds, 39 (55 p.c.) were secondary to MVCs, and the remainder (25; 35 p.c.) were from assaults, falls, and closed head injuries. The non-trauma intubations were for smoke inhalation, overdose, seizure, HIV related complications, eclapsia, and near drowning. Intubations were successful with one attempt in 65 (78 p.c.) cases. No surgical airways were necessary. Rocuronium was used in 4 cases. Protocol deviations did not lead to complications. Conclusions: This protocol based pediatric rapid sequence intubation method worked well in an EM residency program. More intubations were in males and more were necessary due to trauma in this group.

180/2523

Tytuł oryginału: Side clamp used during off-pump coronary artery bypass does not increase the risk of stroke.
Autorzy: Hirose Hitoshi, Amano Atsushi, Takahashi Akihito
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR235-CR240, tab., bibliogr. 13 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: The purpose of this study was to investigate whether the incidence of stroke after off-pump AC bypass was lower than that after on-pump AC bypass. Material/Methods: A prospective study was performed with consecutive patients who underwent isolated AC bypass in the Shin-Tokyo Hospital Group between July 1, 1996 and December 31, 2001 AC bypass was defined as coronary artery bypass requiring proximal anastomoses onto the ascending aorta. The patietns were divided into two groups, depending on the use of cardiopulmonary bypass: on-pump and off-pump groups. Perioperative data were prospectively collected and the risk factors for postoperative stroke were investigated. Resutls: Preoperative comorbidiites were more frequent in the off-pump group. The number of distal anastomoses was not significantly different but the number of proximal anastomoses was significantly greater in the on-pump group than in the off-pump group. The incidence of postoperative stroke was 0.3 p.c. in the off-pump group and 2.0 p.c. in teh on-pump group. Significant risk factors influencing the occurrence of postoperative stroke included: use of cardiopulmonary bypass, age over 75, peripheral vascular disease, saphenous vein use, and postoperative atrial fibrillation. Multivariate analysis demonstrated that the use of cardiopulmonary bypass, age over 75, and peripheral vascular disease were isolated predictors of postoperative stroke. Conclusions: The incidence of postoperative stroke was lower in the off-pump group than in the on-pump group, even though the side clamp was applied to the ascending aorta for aortocoronary bypass. The use of side clamping for off-pump AC bypass does not increase the risk of postoperative stroke.

181/2523

Tytuł oryginału: Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease.
Autorzy: Fernandez Hubert H., Lapane Kate L.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR241-CR246, tab., bibliogr. 63 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Little is konwn about predictors of mortality among Parkinson patients living in long term care. Material/Methods: We conducted a 3-year follow-up study on 15,237 PD residents aged 65 years and older using the Systematic Assessment in Geriatric drug use via Epidemiolgoy (SAGE) database. The SAGE database consists of the Minimum Data Set (MDS) data collected on over 400,000 nursing home residents in 5 U.S. states, including demographic characteristics, demntia severity, comorbidity and other clinical variables. Information on death was derived through linkage to Medicare files. Baseline characteristics were used to predict survival using univariate and multivariate Cox proportional hazard models. Results: The overall 3-year mortality rate was 50 p.c. Advanced age (relative rate (RR) 2.22; 95 p.c. confidence interval (CI) 1.99 - 2.47, for patients 85+ years), male gender (RR 1.73; 95 p.c. CI 1.60 - 1.87), severe functional (RR 1.81; 95 p.c. CI 1.53 - 2.13) and cognitive (RR 1.54; 95 p.c. CI 1.38 - 1.72) impairment, the presence of vision problems (RR 1.25; 95 p.c. CI 1.20 - 1.57), pressure ulcers (RR 1.25; 95 p.c. 1.14 - 1.37), and a diagnosis of congestive heart failure (RR 1.49; 95 p.c. CI 1.35 - 1.65), diabetes mellitus (RR 1.22; 95 p.c. 1.11 - 1.35) and pneumonia (RR 1.39; 95 p.c. CI 1.09 - 1.77) were independent predictors of death. The specific presence of aspiration pneumonia had the highest mortality risk ratio among all comorbidities (RR 1.58; CI 0.97 - 2.56). Africa-Americans and other minority groups were less likely to die relative to whith PD residents...

182/2523

Tytuł oryginału: Causes for early reintervention after thyroidectomy.
Autorzy: Hurtado-López Luis Mauricio, Zaldivar-Ramirez Felipe Rafael, Kuba Erich Basurto, Cejudo Abraham Pulido, Flores Jose Humberto Garza, Solis Oscar Muńoz, Castillo Carlos Campos
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR247-CR250, tab., bibliogr. 12 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: The purpose of our study was to ascertain the causes for early reintervention after thyroidectomy performed by a surgical team using a systematized surgical technique. Material/Methods: We analyzed 1131 patietns, 939 (83.1 p.c.) women and 192 (16.9 p.c.) men, average age 38.7 years (range 12 to 79). Of these patients, there were 675 hemithyroidectomies with isthmusectomy (59.74 p.c.), 189 subtotal thyroidectomies (16.71 p.c.), and 267 total thyoidectomies, alone or with regional lymphatic dissection at levels VI and VII (23.55 p.c.). Statistical analysis was performed by main tendency measures and chi square (chi-squared) for comparison of two independent samples; the dependent variable was the rate of early reintervention, while the independent variables included causes, time of presentation, hormonal functional state and extent of surgery. Results: Early reintervention was necessary in 11 cases (0.97 p.c.). 9 were due to hematoma (0.79 p.c.) resolved with drainage and hemostasis, and two (0.18 p.c.) due to acute respiratory failure (ARF) caused by laryngeal edema, resolved by tracheostomy. Analysis based on diagnosis, extent of surgery and functional state failed to reveal statistically significant differences. The maximum time presentation of complications was 6 hours. Conclusions: The most intense postoperative monitoring is necessary during the first six hours. The low frequency of early reintervention and the appearance of complications in less than 8 hours enable thyroid surgery to be performed on a short-stay basis with adequate safety margins.

183/2523

Tytuł oryginału: Characteristics and outcome among women and men transported by ambulance due to symptoms arousing suspicion of acute coronary syndrome.
Autorzy: Herlitz Johan, Starke Mia, Hansson Elisabeth, Ringvall Eva, Karlson Bjrn W., Waagstein Lisbeth
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR251-CR256, tab., bibliogr. 13 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: The purpose of this study was to describe the characteristics and outcome in relation to sex in consecutive patients who were transported by an ambulance due to symptoms arousing suspicion of acute coronary syndrome. Materia/Methods: Our reserach involved all patietns transported by ambulance over a 3-month period in the community of Gteborg due to such symptoms. The P-values were age adjusted. Results: Of the 930 transported patietns fulfilling the given criteria, 452 (49 p.c.) were of women. The women were older and had a lower incidence of previous acute myocardial infarction, angina pectoris, and current smoking. Women less frequently had a final diagnosis of acute coronary syndrome (22.3 p.c vs 36.6 p.c.; p 0.0001) or acute myocardial infarction (10.1 p.c. vs 17.9 p.c.; p 0.0001). However, the mortality rate during one year was the same in women (17.2 p.c.) and men (18.7 p.c.). Women were less frequently clammy on admission to the ambulance (17 p.c. vs 30 p.c.; p 0.0001) and less frequently showed signs of myocardial ischemia in ECG upon admission to the emergency department (26 p.c. vs 38 p.c.; p 0.001) compared to men. Among those patietns with an acute coronary syndrome, women more frequently complained of dyspnea than men (27 p.c. vs 12 p.c.; p = 0.018). Conclusion: Our study suggests that among ambulance transported patients with suspicion of acute coronary syndrome there are some differences between women and men in terms of their characteristics and underlying etiology, but not in terms of the risk of mortality.

184/2523

Tytuł oryginału: A multi-center open study to determine the effect of lamivudine on HBV DNA clearance and to assess the safety of the regimen in patietns with chronic hepatitis B infection.
Autorzy: Mazur Włodzimierz, Król Franciszek, Cianciara Janusz, Nazzal Khalil, Gładysz Andrzej, Juszczyk Jacek, Bolewska Beata, Adamek Jacek, Czajka Barbara, Świętek Katarzyna, Kryczka Wiesław, Gonciarz Zbigniew
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR257-CR262, il., tab., bibliogr. 19 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Patietns with on-going HBV viral replication often present with clinical features of active chronic hepatitis. Until the recent introduction of nucleoside analogues, interferon-alpha was the only approved drug for these patietns. One of the former drugs, lamivudine, has been shown in clinical trials in the US and Asia to effectively inhibit the viral polymerase of HBV. Our study was undertaken to assess the efficacy and safety of lamivudine therapy in Polish patietns with chronic hepatitis B. Material/Methods: Forty-five patients with chronic hepatitis B (HBeAg positive, anti-e negative, HBV-DNA positive by hybridization assay) were enrolled in the study. The patietns received 100 mg of lamivudine orally, once daily for 12 months. They returned for routine clinical and laboratory control every two weeks during the first months of treatment, and later at 3-month intervals whle receiving lamivudine. Results: At the end of treatment, serum HBeAg was not detected in 21 patients (48.8 p.c.), and anti-HBe appeared in the serum of 19 patients. 37.2 p.c. of the patietns in the study group showed sustained suppression of serum HBV DNA at the end of treatment. Lamivudine therapy was well tolerated, with the rate of occurrence of adverse events similar to that observed in other clincial studies. Conclusions: 12-month lamivudine therapy in this Polish population of patients with chronic hepatitis B induced a high rate of HBeAg seroconversion, accompaneid by reduction of HBV-DNA and the normalization of alanine aminotransferase activities.

185/2523

Tytuł oryginału: Level of antithrombin III, protein C, protein S and other selected parameters of coagulation and fibrinolysis in the blood of the patietns with recurrent deep venous thrombosis.
Autorzy: Świątkiewicz Andrzej, Jurkowski Piotr, Kotschy Maria, Ciecierski Marek, Jawień Arkadiusz
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR263-CR268, il., tab., bibliogr. 49 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Thrombophilia is caused mainly by disturbances of hemostasis involving excessive coagulation system activation, reduction of anticoagulation system (antithrombin III, protien C, protien S, RAPC) or fibrinolytic activity. Material/Methods: In 34 young patietns (aged 40 years) with recurrent deep venous thrombosis ( 2 incidents) the activity of antithrombin III, protien C, S, platelet count, adhesion and aggregation, APTT, stipven-kephalin, prothrombin time and INR were investigated. Fibrinogen, factor XIII, ELT, FDP, Ag t-PA levels, antigen concentration and PAI-1 activity were determined. Patietns with idiopathic DVT, after elimination of most important thromboembolism risk factors, were qualified for the study. DVT was confirmed in all patients by phlebography, plethysmography and ultrasonography. Results were compared with a group of 54 healthy controls. Results: In almost 50 p.c. of patients with recurrent DVT (15/34) decrease of at least one plasma coagluation inhibitor (AT III, PC, PS) level was observed. In the patient group (with AT III and/or PC and/or PS decrease) statistically significant reduction of kaolin-kephalin time in comparison with controls was observed (ŕ 0.01). Analysis of fibrinolysis system demosntrated significant factor XIII level decrease (to 58.3 p.c.), fibrinogen level increase, ELT prolongation, and fibrinogen and fibrin degradation product increase in comparison with controls. THe patients demonstrated 3-fold higher t-PA antigen level (13.1 ng/ml, ŕ 0.0001) and over 3-fold higher PAI-1 activity (26.7 AU/ml, ŕ 0.001) than healthy controls...

186/2523

Tytuł oryginału: Assessment of iron metabolism in children with chronic hepatitis B - prognostic factor in interferon alpha therapy.
Autorzy: Chrobot Andrzej, Chrobot Agnieszka Monika, Szaflarska-Szczepanik Anna
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR269-CR273, tab., bibliogr. 20 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

pediatria

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: The aim of the study was to assess iron metabolism in children with chronic hepatitis B and to establish whether it had any influence on the results of interferon alpha therapy. Material/Methods: The study was carried out in a group of 38 children aged from 2 to 16 years with chronic hepatitis B diagnosed according to serological, biochemical and histopathological criteria. All the patietns were treated according to the commonly adopted schedule: interferon alpha administered subcutaneously three times a week at 3 MIU doses for 20 weeks. During the therapy and one-year follow-up after its completion, biochemical liver function parameters, serological HBV markers, and iron and ferritin levels were monitored. Results: The therapy resulted in obtaining seroconversion in the HBe system in 9 patients (23.68 p.c.). Liver bioptates in that group of patients demonstrated more advanced changes due to inflammatory activity and fibrosis processes, significantly higher values of alanine aminotransferase, lower serum levels of iron and ferritin with more pronounced difference in ferritin levels, although the differences reached no statistical significance. Conclusions: No disturbances of iron metabolism were observed in children with chronic hepatitis B. In the group of patietns with detectable seroconversion in the Hbe system resulting from interferon alpha therapy, lower serum levels of iron and ferritin were observed. Reoutine determinations of serum iron and ferritin levels as a prognostic factor for positive response to interferon alpha seem to be of little use, especially in children, in whom no iron accumulation in liver tissue is observed in histopathological assessment of liver bioptates.

187/2523

Tytuł oryginału: Course of viral hepatitis B and combined B and C hepatitis in children treated for neoplastic diseases.
Autorzy: Kołtan Sylwia, Wysocki Mariusz, Kołtan Andrzej, Świątkiewicz Violetta, Styczyński Jan, Dębski Robert, Balcar-Boroń Anna
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR274-CR279, il., tab., bibliogr. 36 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Viral hepatitis C in children is milder than in adults. Patients with tumors, because of immune deficits, seem to be at risk of rapid liver disease progression. Little is known about the course of HCV and dual HBV-HCV infections in such patients. Material/Methods: The study assessed clinical courses of HCV and dual HBV-HCV infections in 249 children with tumors aged 1-18 years, divided into four groups: with HCV infection - 53, HBV-HCV infection - 53, HBV only - 33 and ifection-free - 110. Results: Hepatitis C was often chronic - in 83.3 p.c of patients with HCV and 77.3 p.c. of those with dual infection. Over 80 p.c. had no jaundice. Mean AIAT activity was the highest in the HCV group (149.2 ń 202.7 IU/l), lower in the dual infection group (123.3 ń 148.1 IU/l; p 0.02), and the lowest in HBV (92.7 152.9 IU/l. Transaminasemia course in patients with HCV and dual HBV-HCV infections was most frequently fluctuating (50.9 p.c. and 45.3 p.c., respectively). 52.8 p.c. of children with HCV demonstrated no advanced inflammatory lesions with invasion of the lamina limitans, no marked fibrosis, and minimum changes in descriptive classification. In 92.3 p.c. of children with dual infections, inflammatory activity was mild or mean, with no fibrosis in 61.5 p.c., and persistnet chronic inflammation predominant in descriptive classification (46.2 p.c.). Conclusions: HCV an HBV-HCV infections in children with neoplastic diseases tend to take chronic forms, but their clinical course is mild with signs of severeinflammatory activity or hepatitic strom aremodeling observed on histopathology.

188/2523

Tytuł oryginału: Total IgE levels and skin test results in children under three years of age with food hypersensitivity.
Autorzy: Malinowska Elżbieta, Kaczmarski Maciej, Wasilewska Jolanta
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR280-CR287, il., tab., bibliogr. 43 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: The most common tools of allergologic diagnostics are skin prick tests (SPT) and total serum IgE (IgE total) determinations. Material/Methods: The study was carried out in a group of 348 children aged 5 to 36 months. All the children underwent SPT using 12 food allergens and in 229 of them also 9 inhalant allergens were tested. Assessment of test positivity utilized relative criteria, i.e. the result was regarded as positive if a wheal with S surface area exceeding or equal to 0.25 of the surface area SO of a control wheal was formed. In this study group, 291 had IgE total levels determined. They were divided into the groups with elevated and normal IgE total levels on the basis of two standards, i.e. the standards recommended by the manufacturer of the test reagents used to determine IgE total (BioWhittaker) and the population standards. Resutls: Positive SPT results for food allergens were obtained in 15.8 p.c. of the examined children, for inhalant ones in 21.8 p.c. The factors taken into account in the analysis of impact on SPT results included age, sex, living place and the use diet. Elevated IgE total levels according to the manufacturer's standards were detected in 35.0 p.c., and according to the population standards in 67.0 p.c. of the examined children. The obtained positive test results were compared with elevated IgE total in the studied patients.Conclusions: 1. Feasibility of SPT at this age. 2. Determination of normal IgE total range in the group of children below three requires further studies.

189/2523

Tytuł oryginału: Salt iodination as a effective method of iodine supplementation.
Autorzy: Grzesiuk Wiesław, Kondracka Agnieszka, Słoń Milena, Wojda Marzena, Nauman Janusz
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR288-CR291, il., bibliogr. 18 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: In January 1997 a new approach to preventing iodine deficiency was introduced in Poland. The goal of the present study was to determine whether the mandatory iodization of kitchen salt (30 mg KI/kg) has had any impact on ioduria. Material/Methods: The study was performed on 29 healthy volunteers, aged 22-29 (average age 23.93 ń 1.14), examined in 1996 and retested after 36 months of iodine supplementation in 1999. Each person underwent a physical examination and thyroid ultrasonography. The iodine level was determined using morning urine samples. Results: For the duration of the study thyroid volume remained unchanged, ranging from 11.48 ń 3.89 ml in 1996 to 12.11 ń 3.85 ml in 1998. THe echostructure was normal in all subjects both in 1996 and in 1999. In 1996 the iodine concentration in urine (ICU) in the study group averaged 100.4 ń 41.5 ćg/L (range from 43.3 to 175.6 ćg/L). Seventeen persons had an iodine cncentration below 100 ćg/L. In 1999 the average ICU was 140.7 ń 78.87 ćg/L. Three subjects had a lower ICU in 1999 (53.93 ń 24.65 ćg/L) than in 1996 (104.1 ń 24.6 ćg/L). These persons claimed to have completely eliminated the use of added salt in their diet. Conclusion: We conclude that mandatory iodine supplementation method is sufficiently effective when salt is used in the diet. In the case of restrictions on salt consumption the use of preparations containing iodine should be recommended.

190/2523

Tytuł oryginału: Drug-induced liver damage - a three-year study of patients from one gastroenterological department.
Autorzy: Hartleb Marek, Biernat Łukasz, Kochel Anna
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR292-CR296, tab., bibliogr. 22 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Bakcground: The aim of our study was to analyze drug-induced liver disease over a 3-year period in one gastroenterological department. Material/Methods: International consensus standard definitions and criteria for assessing causality of adverse drug reactions were applied to all patients with abnormal hepatic test results. Results: Drugs were implicated in hepatic injury in 14 patietns (8 females) in whom causal relationship between drug and liver disease was definite or highly probable. The drugs responsible were amoxicillin with clavulanic acid (3 cases), fluvastatin and pravastatin (3 cases), antituberculous drugs (2 cases), estrogens, roxithromycin, asacol, satolol, enalapril and thiamazol. A total of 78.6 p.c. (11 cases) were classified as hepatocellular or mixed hepatitis, while cholestatic injury was found in 21.4 p.c. (3 cases). There were no lethal or severe (prothrombin 50 p.c.) hepatic drug reactions. In 13 patietns the course of liver disease after with drawal of the offensive drug was either acute or protracted, while in one patient there was chronic cholestasis ( 3 years) resulting from injury to interlobular bile ducts by amoxicllin with clavulanic acid. Conclusion: A thorough history of drug intake should be taken in all patients presenting with abnormal hepatic test results. Amoxicillin & clavulanic acid, cholesterol-lowering and antituberculin drugs were the most frequent hepatotoxic factors in our patients. In a majority of cases the liver injury was not severe, and resolved after prompt withdrawal of the responsible drug.

191/2523

Tytuł oryginału: Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma - a double-blind randomized placebo-controlled multicentre clinical trial.
Autorzy: Goldstein Marc F., Chervinsky Paul
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR297-CR304, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Background: Experimental studies have shown that doxofylline is endowed with a remarkable bronchodilator activity with less extra-respiratory effects than theophylline. This trail was designed to compare the efficacy and safety of doxofylline, theophylline, and placebo in patients with chronic reversible bronchial asthma. Material/Methods: Three hundred forty-six patietns were randomly assigned to a 12-week oral treatment with either doxofylline 400 mg t.i.d. (high dose), doxofylline 200 mg t.i.d. (low dose), theophylline 250 mg t.i.d. (active control) or placebo. Pulmonary function tests (PFTs) were performed biweekly. Patients kept records of peak flow meter (PFM) measurements, asthma attack rate and beta-2-agonist use (albuterol). Results: Changes in FEV1 2 hours after the administration of treatments versus baseline exhibited statistically significant differences between doxofylline 400 mg t.i.d. and placebo and between theophylline and placebo. Similar differences were monitored on the other variables (FVC, PFER, FEF25-75 p.c. Asthma attack rate and use of albuterol decreased remarkably with doxofylline 400 mg t.i.d. and theophylline. There were few statistically significant differences between doxofylline 200 mg t.i.d. and placebo. Significantly more patients had to interrupt treatment because of adverse events under theophylline than under doxofylline 400 mg t.i.d. (p=0.001). With doxofylline 400 mg t.i.d., the number of patietns treated to spare one dropout due to theophylline was 5. Conslusion: This study provides evidence that doxofylline 400 mg t.i.d. is an effective treatment for relieving airway obstruction and displays a better safety profile with respect to theophylline 250 mg t.i.d. with a favorable risk-to-benefit ratio.

192/2523

Tytuł oryginału: Comorbid disease profiles of adults with end-stage hip osteoarthritis.
Autorzy: Marks Ray, Allegrante John P.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR305-CR309, il., tab., bibliogr. 38 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli = 65 r.ż.

Streszczenie angielskie: Background: Although hip osteoarthritis is a common disabling condition, an incomplete understanding of all factors that contribute to hip osteoarthritis disability persists. The objective of the study was to improve our understanding of potentially preventable factors that might influence hip osteoarthritis disability by examining the prevalence and impact of selected comorbid factors potentially associated with the progression and severity of hip joint osteoarthritis among patietns with end-stage hip osteoarthritis. Material/Methods: The mdical records of 1,000 hip osteoarthritis surgical patients were assessed to specifically identify the presence or absence of comorbid conditions of the cardiac, vascular or respiratory systems. The assocaition between the patient's functional status before and after surgery, and the presence or absence of these comorbid conditions, was assessed. Results: Over 55 p.c. of the sample had at least one comorbid condition, such as hypertension or cardiac disease. After controlling for age, trauma, type of surgery and gender discrepancies, those with two or more comorbidities were found to have greater degrees of functional impairment before surgery, and lower post-operative functional status after surgery than those with no coexistent disease (P 0.05). Conclusion: Patietns with end-stage hip osteoarthritis exhibit a high prevalence of vascualr-related comorbidities. THe disability of patients with hip osteoarthritis is increased in the presence of two or more related comorbid conditions. These findings suggest a novel focus for primary, secondary and tertiary preventive strategies.

193/2523

Tytuł oryginału: Combination of pamidronate and thalidomide in the therapy of treatment-resistant multiple myeloma.
Autorzy: Ciepłuch Hanna, Baran Wojciech, Hellmann Andrzej
Źródło: Med. Sci. Monitor 2002: 8 (4) s.PI31-PI36, il., tab., bibliogr. 21 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

hematologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Background: Bisphosphonates inhibit the activity of osteoclasts and demonstrate antitumor effect, involving induction of plasmocyte apoptosis, blocking of angiogenesis, stimulation of Tçë lymphocytes and inhibition of metalloproteinases. Bisphosphonates combined with thalidomide, a drug possessing confirmed anti-myeloma activity, seem to have potential favorable effect in patietns with treatment-resistant multiple myeloma with advanced osteolytic lesions. Material/Methods: 13 patietns with treatment-resistant multiple myeloma with advanced osteolytic lesions received combined pamidronate and thalidomide therapy. All the patietns underwent detailed clinical and laboratory control once a month. Pamidronate was used at 90 mg iv dose administered at 4-week intervals, and thalidomide at doses escalated from 200 mg/d in the first week to 400 mg/d after 3 weeks of the therapy. The mean duration of treatment was 12 weeks with a range of 3 to 36 weeks. Results: 7 patietns (53 p.c.) receiving pamidronate and thalidomide therapy demonstrated good response involving at lesast 25 pc. reduction of monoclonal protein levels in comparison with baseline. All these patietns reported improvement of osteodynia symptoms, and 3 of them - thier complete regression. 70 p.c. patients experienced side effects (dizziness, constipation, somnolence, polyneuropathy) due to thalidomide administration. Conclusion: Good response to combined pamidroante and thalidomide therapy can be expected in at least 50 p.c. of patietns with treatment-resistant multiple myeloma with advanced osteolytic lesions.

194/2523

Tytuł oryginału: Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.
Autorzy: Rajtar Grażyna, Żółkowska Dorota, Kleinrok Zdzisław
Źródło: Med. Sci. Monitor 2002: 8 (4) s.PI37-PI44, il., tab., bibliogr. 40 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Background: Benzodiazepine binding sites distnict from the GABA-receptor-chloride-complex in the central nervous system have been recongized in many peripheral tissues, but their physiological role remains unexplained. Our study was undertaken to examine the effects of diazepam, clonazepam, and PK 11195, a peripheral benzodiazepine receptor antagonist, on the functional and biochemical responses of platelets and neutrophils stimulated by different physiological agonists. Material/Methods: The experiments were conducted on isolated washed rat platelets activated by arachidonic acid (AA), adenosine 5'-diphosphate (ADP), or thrombin and on isolated rat neutrophils activated by a chemotactic peptide, formyl methionyl leucyl phenylalanine (fMLP). Results: The results showed that neither diazepam nor clonazepam nor PK 11195 alone augmented the reponse of resting platelets or modified neutrophil reponse, but diazepam and clonazepam in a concentration-dependent manner inhibited thrombin, ADP or AA-stimulated platelet aggregation and the thrombin-induced increase in free intracellular Caý+. Both drugs also exerted an inhibitory effect on reactive oxygen species (ROS) produced by fMLP-stimulated neutrophils. However, diazepam was about 10 times more effective than clonazepam. PK11195 did not influence platelet and neutrophil function stimulated by agonists, but reversed the inhibitory action of both benzodiazepines on platelet activation and ROS production. Conclusions: The results indicated that invitro diazepam, and in a much smaller degree clonazepam, may down-regulate platelet activation and release of some proinflammatory mediators by stimulated neutrophils. These effects are probably exerted by a specific benzodiazepine binding sites.

195/2523

Tytuł oryginału: Rehabilitation outcome in a patient awakened from prolonged coma.
Autorzy: Talar Jan
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CS31-CS38, il., tab., bibliogr. 20 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Background: This article describes the rehabilitation of a patient recovering from a prolonged coma (defined as lasting longer than 4 weeks). The case is noteworthy because it exemplifies the possibilities and difficulties entailed in treating these patients, who are often regarded as too severely impaired to justify intensive rehabilitation efforts. Case report: The patietn is a 28-year old Polish male, unmarried, who suffered serious closed head injuries in an automobile accident in April of 1999. He was in a comatose state for more than two months, with a GCS score of 5. When admitted for rehabilitation he was bedriedden, wht global aphasia, agraphia, limb apraxia, and executive dysfunction. THe rehabilitation program developed for him is described in detail. Results: Over the course of rehabilitation, which began in December 1999 and continues to this writing, the patient has regained locomotion capabilities (though with impairments), and his speech has improved considerably. The apraxia has largely resolved, and he is able to write his name and copy words. he is now capable of performing many activities of daily living. Conclusions: A comprehensive program of rehabilitation characterized by a strategic, heurisitic approach is capable of achieving a good outcome even in very difficult cases, such as prolonged coma.

196/2523

Tytuł oryginału: Non-valvular isolated pulmonary artery vegetations.
Autorzy: Farsak Bora, Yilmaz Mustafa, c Mehmet, zkutlu Sheyla, Demircin Metin
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CS39-CS41, il., bibliogr. 9 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

niemowlęta

płeć męska

Streszczenie angielskie: Background: One of the serious potential complications of complex congenital heart defect (CHD) is bacterial endocarditis. Right sided endocarditis accounts for 5-10 p.c. of all cases of infective endocarditis, with the tricuspid valve more frequentlly affected than the pulmonary valve. Pulmonary artery involvement in bacterial endocarditis is very rare, but when it exists it is almost always associated with endocarditis of the pulmonary valve: isolated pulmonary artery vegetations have not previously been reported before. Case Report: A 6-year-old boy with atrial septal defect (ASD), ventricular septal defect (VSD), coarctation of the aorta (CA), persistent ductus arteriosus (PDA) and pulmonary hypertension, who had been operated for closure of PDA, correction of CA and pulmonary artery banding, was readmitted with bacterial endocarditis. In surgery, the VSD was closed with a Dacron patch using interrupted pledget buttressed sutures, and the ASD was closed using primary sutures. After debanding, while pulmonary arteriotomy was performed for patch angioplasty, we observed that the entire pulmonary artery trunk, right and left pulmnary artery branches, were filled with a solid mass, which was successfully treated by surgical excision. Conclusion: With ongoing improvements in diagnostic tools, especially in echocardiography, antibiotic therapy and surgery, CHD can now be treated successfully in early infancy or childhood.

197/2523

Tytuł oryginału: Dynamic magnetic resonance imaging in soft tissue tumors - assessment of the diagnostic value of tumor enhancement rate indices.
Autorzy: Tacikowska Małgorzata
Źródło: Med. Sci. Monitor 2002: 8 (4) s.MT53-MT57, tab., bibliogr. 18 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

pediatria

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

dorośli 45-64 r.ż.

Streszczenie angielskie: Background: Dynamic MRI is routinely used in the diagnosis of soft tissue tumors to supplement static imaging. The aim of our study was to assess the diagnostic value of dynamic MRI using the coefficient of total tumor enhancement expressed as per cent (tec p.c.) and the tumor enhancement rate coefficient expressed as per cent per minute (erc p.c./min), and to make a comparative analysis of the sensitivity and specificity of both parameters. Material/Methods: The material consisted of 45 patietns (30 sarcomas, 15 non-malignant lesions). The age of the pateitns was 16-64 years. The MRI was done using an Elscint 2T unit, applying gradient echo techniques. The coefficient of total contrast enhancement (tec p.c.) and the tissue enhancement rate (erc p.c./min) were calcuatated. The limit values were determined for dividing the tumors into sarcomas and non-malignant lesions. The sensitivity and specificity of MRI were calculated and compared using both indices. Results: Dynamic MRI with calculation of erc p.c./min and tec p.c. makes it possible to differentiate between sarcomas and non-malignant lesions. Conclusions: The erc p.c./min was a more sensitivie than tec p.c. differentiating parameter in the diagnosis of soft tissue tumors.

198/2523

Tytuł oryginału: A radical approach to cancer.
Autorzy: Das Undurti N.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.RA79-RA92, il., bibliogr. 173 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: Reactive oxygen species are known to be potentially dangerous, but are also needed for signal-transduction pathways. Tumor cells have relatively low amounts of superoxide dismutase (SOD), which quenches superoxide anion (o2) and as a result of a higher level of aerobic metabolism, higher concentrations of O2, compared to normal cells. But this may not be true of all tumor cells. Some tumor cells have relatively higher amounts of vitamin E, a potent antioxidant, and a higher level of anaerobic metabolism, resulting in a balance that is tilted more towards higher anti-oxidant capacity. In both instances of higher aerobic and anaerobic metabolism methods designed to augment free radical generation in tumor cells can cause their death. It is suggested that free radicals and lipid peroxides suppress the expression of Bcl-2, activate caspases and shorten telomere, and thus inducing apoptosis of tumor cells. Ionizing radiation, anthracyclines, bleomycin and cytokines produce free radicals and thus are useful as anti-cancer agents. But they also produce many side-effects. 2-methyoxyoestradiol and polyunsaturated fatty acids (PUFAs) inhibit SODs and cause an increase of O2 in tumor cells leading to their death. In addition, PUFAs (especially gamma-linolenic acid), 2-methoxyoestradiol and thalidomide may possess anti-angiogenic activity. This suggests that free radiocals can suppress angiogenesis. Limited clinical studies done with gamma-linolenic acid showed that it can regress human brain gliomas without any signficant side-effects. Thus, PUFAs, thalidomide and 2-methoxyoestradiol or their derivatives may offer a new radical approach to the treatment of cancer.

199/2523

Tytuł oryginału: Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats.
Autorzy: Mikołajczak Przemysław, Okulicz-Kozaryn Irena, Kamińska Ewa, Niedopad Lidia, Polańska Anna, Gębka Joanna
Źródło: Eur. J. Pharmacol. 2002: 444 (1/2) s.83-96, il., tab., bibliogr. s. 94-96
Sygnatura GBL: 312,088

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

szczury

Streszczenie angielskie: The aim of this study was to evaluate the effect of multiple acamprosate (500.0 mg/kg, p.o.) administration on short-term memory, using te social recognition test in rats. Ifenprodil (1.0 mg/kg, i.p.), arcaine (5.0 mg/kg, i.p.) and spermidine (20.0 mg/kg, i.p.) were chosen as polyamine ligands and their action or interaction with acamprosate was also studied. The doses used did not show any sedative activity, which was assessed by measuring locomotor activity and the hypnotic effect of ethanol. The findings suggest that acute acamprosate treatment did not impair short-term memory. Multiple acamprosate and a single spermidine or arcaine administration led to better performance in the memory test, whereas no significant difference was observed in ifenprodil-treated rats. Co-administratio of a single arcaine or spermidine dose with multiple acamprosate produced worse results. This means that the effect of repeated acamprosate administration can be changed by the co-administration of other polyamine ligands, so that care should be taken in interpreting.

200/2523

Tytuł oryginału: Repeated imipramine and electroconvulsive shock increase ŕ1A-adrenoceptor mRNA level in rat prefrontal cortex.
Autorzy: Nalepa Irena, Kreiner Grzegorz, Kowalska Marta, Sanak Marek, Zelek-Molik Agnieszka, Vetulani Jerzy
Źródło: Eur. J. Pharmacol. 2002: 444 (3) s.151-159, il., tab., bibliogr. s. 158-159
Sygnatura GBL: 312,088

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

szczury

Streszczenie angielskie: ŕ1-Adrenoceptors have been implicated in the mechanism of action of antidepressants, but their action on specific receptor subtypes was rarely reported. We compared now the action of two prototypic antidepressant treatments: repeated imipramine and electroconvulsive shock, on the expression of the ŕ1A - and ŕ1B -adrenoceptor mRNAs and on the receptor density in rats. The mRNA expression was assessed by Northern blot in the prefrontal cortex and the hippocampus, the receptor density was measured by [3H] prazosin binding in the total cerbral cortex and hippocampus. In the cortex, both treatments elevated the ŕ1A -adrenoceptor mRNA and the expression of receptor protein. The expression of ŕ1B -adrenoceptor mRNA remained unaffected. In contrast, in the hippocampus, the antidepressant treatments augmented the density of ŕ1A -adrenoceptor protein without changing the level of its mRNA expression there. The results suggest that the ŕ1A -adrenoceptor subtype is specifically involved in the mechanism of action of classical antidepressant treatments.

201/2523

Tytuł oryginału: Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer.
Autorzy: Przybyłowska K., Smolarczyk K., Kulig A., Romanowicz-Makowska H., Dziki A., Ulańska J., Pander B., Błasiak J.
Źródło: Cancer Lett. 2002: 181 (1) s.23-30, il., tab., bibliogr. 18 poz.
Sygnatura GBL: 306,023

Hasła klasyfikacyjne GBL:

immunologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: We analysed the distribution of genotypes of two polymorphisms in the urokinas-type plasminogen activator (uPA) gene: C - T substitution in exon 6 and T - C substitution in intron 7 in 52 subjects with colorectal cancer. Genotypes were determined in tumour tissue and distant mucosa samples by allele-specific polymerase chain reaction. The antigen levels of uPA in cancer tissue were higher than in distant mucosa as measrued by enzyme-linked immunosorbent assay. The level of uPA antigens in cancer samples with the C/C genotype of C - T polymorphism in exon 6 was higher than in samples with C/T and T/T genotypes. No differences in the level of uPA antigens between the alleles of the intron 7 T - C polymorphism were found. As uPA can be involved in cancer invasion and metastasis, C/C genotype in exon 6 of uPA gene can be further considered as being related to colorectal cancer progression.

202/2523

Tytuł oryginału: Hemodynamic performance after stented vs stentless aortic valve replacement.
Autorzy: Jasiński M. J., Hayton J., Kadziola Z., Woś S[tanisław], Sosnowski A. W.
Źródło: J. Cardiovasc. Surg. 2002: 43 (3) s.313-317, il., tab., bibliogr. 10 poz.
Sygnatura GBL: 311,845

Hasła klasyfikacyjne GBL:

transplantologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

dorośli = 65 r.ż.

płeć żeńska

Streszczenie angielskie: Background. Stentless bioprostheses are anticipated to cause improved hemodyanmics and increased longevity over stented bioprosthesis. We have compared echocardiographic analysis of stented bioprosthesis "Freestyle" with stented "Mosaic" bioprosthesis. Because of similar technology (0 pressure fixation, anticalcification) any differences may relate to stent. Methods. Twenty-eight patients undergoing AVR were randomly assigned to receive either stented or stentless. Echocardiograms, by means of M-mode and Doppler were performed early, 3-6 months and 1 year postoperatively. Results. The peak flow velocity was significantly lower in teh stentless group, especially 1 week and 6 months after surgery. Mean transvalvular gradient dropped significantly in stentless group and did not change in stented group. EOA did not change significantly in either of groups. AoV velocity time integral was increasing in stentless group. LV mass had fallen significantly in both groups but degree of mass reduction was comparable. Conclusions. There are marked improvements of stentless valves hemodynamics. However it is not necessary equal to higher degree of LV mass reduction during 1 year follow-up.

203/2523

Tytuł oryginału: Substance P content in the cerebrospinal fluid and fluid perfusing cerebral ventricles during elicitation and inhibition of trigemino-hypoglossal reflex in rats.
Autorzy: Zubrzycka Maria, Janecka Anna
Źródło: Brain Res. 2002: 941 (1/2) s.29-33, il., bibliogr. 47 poz.
Sygnatura GBL: 312,085

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: The aim of this study was to establish whether tooth pulp and periaqueductal central gray (PAG) stimulation affects the release of substance P (SP) into the fluid perfusing the cerebral ventricles in rats. The content of substance P in the cerebrospinal fluid and fluid perfusing cerebral ventricles was determined during incisor pulp stimulation with electrical impulses inducing nociceptive trigeminohypoglossal reflex and then during inhibition of the reflex by stimulation of PAG. Perfusion of the cerebral ventricles was carried out using artificial cerebrospinal fluid (aCSF). SP-like immunoreactivity (SP-LI) was determined in the samples by radioimmunoassay. Samples were collected in four groups: first group - cerebrospinal fluid (CSF); second group - aCSF perfusates without stimulation; third group-aCSF perfusates during incisor pulp stimulation; fourth group-aCSF perfusates during incisor pulp stimulation and simultaneous inhibition of trigemino-hpoglossal reflex by PAG stimulation. It was shown that incisor pulp stimulation led to the increased release of SP-LI into the fluid perfusing cerebral ventricles. Stimulation of PAG reduced the release of SP-LI into the cerebro-ventricular system to the values obtained before the tooth pulp stimulation. The results indicate that PAG significantly inhibits the release of SP-LI into the rat cerebral ventricular system and may be involved in the inhibition of trigemino-hypoglossal reflex.

204/2523

Tytuł oryginału: The beginnings of urology in Kraków: on the 70th anniversary of the founding of the Clinic of Urology.
Autorzy: Dobrowolski Z. F., Swolkien J., Dobrowolska B., Lipczyński W., Jaszczyński J.
Źródło: Br. J. Urol. 2002: 89 (6) s.596-598, bibliogr. 4 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

Typ dokumentu:

praca historyczna

tytuł obcojęzyczny

Wskaźnik treści:

205/2523

Tytuł oryginału: Survival in patients with rare subtypes of renal cell carcinoma.
Autorzy: Grabowski M[arek], Huzarski T., Lubiński J., Sikorski A[ndrzej]
Źródło: Br. J. Urol. 2002: 89 (6) s.599-600, tab., bibliogr. 14 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Objective. To evaluate the survival of patietns with rare malignant histological subtypes of renal cancer. Pateitns and methods. The Heidelberg classification of renal cell carcinoma (RCC) divides tumours into clear cell carcinoma (CCC), papillary cancer (PC), chromophobic cancer (ChC) and collecting duct carcinoma (CDC). Sarcomatoid tumours are in a different subgroup treated as a final stage of histological progression. Between 1990 and 1997, 319 nephrectomies were undertaken because of RCC in 317 patients. In 42 patietns (13 p.c.) the patholgoical findings showed other than CCC; in 13 PC was confirmed histolgoically, in nine ChC, in 11 a mixed type of CCC and sarcomatoid type, in seven a sarcomatoid tumour and in four, CDC. Results. One patietn of the 13 with PC and two of the nine with ChC died. The worst prognosis was in those with CDC, CCC-sarcomatoid and sarcomatoid tumours, as all these patietns died. Conclusion. The histopathological differentiation of RCC into subtypes gives additional useful prognostic information.

206/2523

Tytuł oryginału: Assessing the vascular-stromal coefficient in patients with benign prostatic hyperplasia or prostate cancer using transrectal ultrasonography and power Doppler analysis.
Autorzy: Dobrowolski Z., Jaszczyński J., Drewniak T., Habrat W.
Źródło: Br. J. Urol. 2002: 89 (6) s.601-603, il., tab., bibliogr. 10 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Objectives. To assess a coefficient of theprotatic blood supply in patietns with prostate cancer or benign prostatic hyperplasia (BPH), and thus improve the diagnostic and prognostic variables needed to evaluate patients with prostate cancer. Patietns and methods. The vascular-stromal coefficient was defined as the ratio of the blood vessel surface area and the surface area of the prostate, using power Doppler functions and transrectal ultrasonography. The index was calcualted for the plane of the prostatic surface from the apex to the widest points of the peripheral zone, and for the plane across the highest density of blood vessels in the transition zone. A micobubble contrast agent was used to intensify the acoustic signals from prostatic vessels. The images were reconstructed in three dimensions. In all, 61 patietns with BPH and 32 with confirmed prostate cancer were examined, and compared with a control group of young men. Results. In the horizontal plane crossing the apex of the prostate, the vascular-stromal coefficient was 0.0054 for the controls, 0.0072 for BPH and 0.0067 for cancer. At the level of the highest density of blood vessels the respective values were 0.0083, 0.038 and 0.029. The respective values for the first plane after using the contrast agent were 0.025, 0.092 and 0.0365, and in the second level 0.04, 0.15 and 0.14. Conclusion. The vascular-stromal coefficient measured at both levels was higher in patietns with BPH than in those with cancer or than in the controls. The prostatic vascular system can be computer-reconstructed in three dimensions, allowing an evaluation of asymmetry and other vascular abnormalities...

207/2523

Tytuł oryginału: Correlations among prostatic-specific antigen, Gleason score, staging and grading in patients after radical prostatectomy.
Autorzy: Szymanowski J., Dudek P., Ratajski J., Wysocki M.
Źródło: Br. J. Urol. 2002: 89 (6) s.612-613, tab., bibliogr. 6 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

chirurgia

Typ dokumentu:

praca kliniczna

Wskaźnik treści:

dorośli = 65 r.ż.

płeć męska

Streszczenie angielskie: Objectives. To evaluate the correlation between Gleason grade, T stage, tumour grade and preoperative prostatespecific antigen (PSA) level ( or 20 ng/mL) in patietns after radical prostatectomy (RP). Patietns and methods. The serum total PSA level was measured 3 months before surgery in 87 patients who then undrewent RP between 1994 and 2000; the tumour specimens were staged and graded. Results. There were 57 (66 p.c.) patietns with a PSA level of 20 ng/mL; in this group only four (7 p.c.) patients had a Gleason grade of 7 and eight (14 p.c.) had G3 tumours. Thirty (34 p.c.) patients had a PSA level of 20 ng/mL; in this group only two (7 p.c.) patietns had a Gleason grade of 7 and 26 (87 p.c.) had G1 and G2 tumours. Conclusions. These results confirm our previous observations that the PSA level cannot be use as the only factor to indicate RP in patients with prostate cancer, but further evaluation on more patietns is needed.

208/2523

Tytuł oryginału: Vascular angiographic asymmetry on three-dimensional transrectal power Doppler ultrasonography in patients with organ-confined prostate cancer.
Autorzy: Dobrowolski Z. F., Jaszczyński J., Drewniak T., Habrat W., Kusionowicz J.
Źródło: Br. J. Urol. 2002: 89 (6) s.614-615, bibliogr. 7 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Objective. To assess whether organ-confined prostate cancer not detected on routine transrectal ultrasonography (TRUS) can be detected using threedimensional (3-D) power Doppler methods. Patients and methods. A preliminary trial of the use of TRUS with 3-D power Doppler image reconstruction was conducted in 116 patients being evaluated for lower urinary tract symptoms. Using a microbubble enhancing agent, a adequate horizontal plane allowed the simultaneous visualization and assessment of the symmetry of echogenicity and vascularization of the peripheral area of both prostate lobes, which is not possible in standard TRUS. The peripheral zone vascular asymmetry in the horizontal plane was also assessed retrospectively n those patients with pT2a,b prostate carcinoma. Results. Stage pT2a,b prostate carcinoma was confirmed in 26 patients; in this group, two independent investigators confirmed the vascular asymmetry between the left and right peripheral zone, in the horizontal plane, in 22 patients, giving a sensitivity of 85 p.c. Conclusions. Vascular asymmetry allows guided biopsy in lesions that are invisible using standard TRUS. Microbubble agents are an effective method of increasing the acoustic signals from small vessels of the prostate.

209/2523

Tytuł oryginału: Evaluation of the influence of systemic neoadjuvant chemotherapy on the survival of patietns treated for invasive bladder cancer.
Autorzy: Kolaczyk W., Dembowski J[anusz], Lorenz J[erzy], Dudek K.
Źródło: Br. J. Urol. 2002: 89 (6) s.616-619, il., bibliogr. 13 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

farmacja

Typ dokumentu:

praca kliniczna

Wskaźnik treści:

dorośli 45-64 r.ż.

Streszczenie angielskie: Objective. To assess the influence of neoadjuvant systemic chemotherapy using a modified methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) scheme in patietns with invasive bladder cancer. Patients and methods. Two groups of patients were reviewed retrospectively: group 1 included 51 who received chemotherapy before cystectomy and group 2 included 62 who were treated only with surgery. The mean (range) duration of follow-up was 3.2 (0.25 - 10.25) years. The patients in group 1 were divided into two subgroups: those with tumour confined to the bladder (T1, T2 and T3a) and the remaining patients with tumour beyond the bladder (T3b, T4a,b). The chemotherapy was administered as routine MVAC, except vinblastine and methotrexate were given at 15 and 22 days during the cycle. A mean of three cycles were administered. Results. The 5-year survival rate in group 1 and 2 was 66 p.c. and 58 p.c., respectively (P 0.3); after 8 years of follow-up the survival rates were 58 p.c. and 33 p.c., respectively, and significantly different (P 0.01). Conclusion. Systemic chemotherapy using the modified MVAC scheme in patients subsequently undergoing radical cystectomy improved the survival rate after 8 years of follow-up.

210/2523

Tytuł oryginału: Treatment of high-risk superficial bladder cancer with maintenance bacille Calmette-Gurin therapy: preliminary results.
Autorzy: Kołodziej A., Dembowski J[anusz], Zdrojowy R[omuald], Woźniak P., Lorenz J[erzy]
Źródło: Br. J. Urol. 2002: 89 (6) s.620-622, tab., bibliogr. 6 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

immunologia

Typ dokumentu:

praca kliniczna

Wskaźnik treści:

ludzie

Streszczenie angielskie: Objective. To evaluate, in a prospective study, the effects and results of maintenance therapy with bacille Calmette-Gurin (BCG) in treating patietns with high-risk superficial bladder cancer. Patients and methods. In all, 155 patietns were enrolled in a randomized study of transurethral resection alone (53) or combined with intravesical BCG (102) as a treatmetn for superficial bladder cancer. BCG was administered for six consecutive weeks followed by three weekly instillations in months 3, 6, 12, 18, 24, 30 and 36 after resection. Recurrence, progression, prognostic factors and side-effects were assessed and analysed. Results. After a median (range) followup of 23 (6-42) months, 83 of the 102 patietns treated with BCG (81 p.c.) were disease-free, compared with 24 of the 53 treated with resection alone (45 p.c.). There was also a significant difference in tumour progression and time to progression between the trial arms. The disease progressed in eight patients (8 p.c.) treated with BCG and in 12 (23 p.c.) of those treated by resection alone. Independent risk factors for progression were DNA ploidy status and stage. Only the completion of treatment was predictive of outcome (risk of recurrence) for patietns treated with BCG. Conclusion. Maintenance BCG therapy was better than resection alone in reducing the incidence of recurrence and progression in patietns with high-risk superficial bladder cancer.

211/2523

Tytuł oryginału: Superficial bladder cancer T1G3: the choice of treatment.
Autorzy: Borkowski A[ndrzej]
Źródło: Br. J. Urol. 2002: 89 (6) s.623-627, tab., bibliogr. 41 poz.
Sygnatura GBL: 300,816

Hasła klasyfikacyjne GBL:

urologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

212/2523

Tytuł oryginału: Multivariate inference in clinical trials - tests with model choice, confidence regions.
Autorzy: Luter J., Kropf S.
Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.5-16, il., tab., bibliogr. 16 poz.
Sygnatura GBL: 306,224

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: In the paper, the formerly introduced spherical multivariate tests are coupled with procedures for selecting the relevant variables. These procedures work in such a way that a non-relevant set of variables is chosen with the probability of significance ŕ, at most. Furthermore, a new method of the calculation of linear principal-component scores is presented, which is based only on the within-sample covariances and yields, nevertheless, a level-ŕ test in each case. This method enables us to determine novel multivariate confidence regions of the unknown mean vector. The statistical procedures are demonstrated by a neurological example.

213/2523

Tytuł oryginału: Grade exploratory methods applied to some medical data sets.
Autorzy: Pleszczyńska Elżbieta, Szczęsny Wiesław
Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.17-30, il., tab., bibliogr. 16 poz.
Sygnatura GBL: 306,224

Hasła klasyfikacyjne GBL:

psychiatria i psychologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Two sets of medical categorical data are analysed by means of grade exploratory methods, based on one fundamental procedure called the grade correspondence analysis (GCA). A special attention is put on visualization. The paper is a contribution to discussion concerning visualization of categorical data, which is going on in contemporary statistical literature.

214/2523

Tytuł oryginału: On the generalised affinity coefficient for complex data.
Autorzy: Bacelar-Nicolau Helena
Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.31-42, il., tab., bibliogr. 26 poz.
Sygnatura GBL: 306,224

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: This paper concerns the affinity coefficient and extensions for measuring the similarity between data units in classification, when we are dealing with large and complex databases. More precisely we refer to the extended weighted affinity coefficient and its role in hierarchical classification, when we are dealing with a generalised data table where the cells can contain a set of values, describing a probability distribution, a histogram (frequency distribution), or integer frequencies, for instance, instead one single value. Here we study the case of frequency distributions, since in our approach the other cases appear to be derived as a generalisation (integer frequencies, real data, for instance) or else as a particular case (binary data, ordinal data) of this one. Either the weighted affinity or the probablistic associated coefficients can be extended, in the clustering viewpoint, to hierarchical (and non-hierarchical) aggregation criteria and aggregation adaptive (parametric) families. An application to a real case is presented.

215/2523

Tytuł oryginału: Clinical databases orginating in electronic patients records.
Autorzy: Zvarova Jana
Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.43-60, il., bibliogr. 16 poz.
Sygnatura GBL: 306,224

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The paper is focusing on new technologies to standardize electronic documentation in Czech healthcare environment. Various approaches for collecting and stroing biomedical information using new information technologies are considered with respect to all legislative and standarization norms in the Czech Republic. Development of new approaches is based on experience gethered in the European 14C-TripleC project. New approaches for implementation of European ideas in the Czech healthcare environment are given. The focus on Czech healthcare, cultural and socio-economic factors in development of electronic healthcare record is presented. Special features of electronic healthcare record to serve in telematic applications for exploring electronic medical guidelines and medical decision support systems are discussed.

216/2523

Tytuł oryginału: Computer support of detecting risk of cardiovascular diseases.
Autorzy: Franek Petr, Tomeckova Marie, Zvarova Jana
Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.61-68, il., tab., bibliogr. 9 poz.
Sygnatura GBL: 306,224

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The paper is focusing on analysis of data collected in twenty years lasting longitudinal study of 1417 middle-aged men living in the second district of Prague. Examination of methods that can support estimation of the risk of cardiovascular disease development in time is done. These methods examined were neural networks, discriminant analysis and logistic regression. The final comparison was done according to percentage of correct decicions and using ROC curves.

217/2523

Tytuł oryginału: Physical and mathematical model of human hip joint load.
Autorzy: Włodarski Jerzy, Szmigiel Andrzej, Żołtyński Krystian, Kaczmarek Jan
Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.95-102, il., bibliogr. 12 poz.
Sygnatura GBL: 306,224

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: Analysing human gait cyclogram and reactions of the foundation, kinematics and dynamics of loads realised on a test stand were tried to be brought closer to real object. To reconstruct hip joint load digram, basic loads resulting from physiology of movement were isolated. Physical model conditioned on gait cyclogram is designed to describe physical load of human hip joint and may be presented in the form of characteristic "double peak". Mathematical model of human hip joint load approximates with good accuracy time serious of five harmonics. This model has been adapted for the realisation of the design for a test stand - human hip joint simulator enabling to perform static and dynamic testing of an artificial hip joint.

218/2523

Tytuł oryginału: Vasopressinergic innervation of the pig pineal gland.
Autorzy: Przybylska-Gornowicz Barbara, Lewczuk Bogdan, Moller Morten
Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.3-8, il., bibliogr. 30 poz.
Sygnatura GBL: 304,846

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

Świnie

płeć żeńska

Streszczenie angielskie: An immunohistochemical study of the pineal gland of the domestic pig was carried out using the antisera raised against vasopressin (VP). The pineal glands were taken from the newborn, 21-day- and 7-month old female pigs. The pig pineal glands is moderately innervated by VP-immunoreactive nerve fibers. They run from the habenular commissure into the connective tissue septa and further into the pineal parenchyma. In the subependymal tissue as well as in the connective tissue septa, the fibres are smooth or with small varicosities and in the parenchyma with large ones. The obtained results point to extrapineal and extraepithalamic source of the fibres. The density of VP-immunoreactive fibers in the pineal gland of 7-month old pigs is higher than in the younger animals.

219/2523

Tytuł oryginału: Influence of 4-day long treatment with vasoactive intestinal peptide on ultrastructure and function of the rat pinealocytes in organ culture.
Autorzy: Nowicki Marcin, Lewczuk Bogdan, Przybylska-Gornowicz Barbara
Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.9-16, il., bibliogr. 35 poz.
Sygnatura GBL: 304,846

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: Vasoactive intestinal peptide (VIP) is one neuropeptides involved in the regulation of the pineal gland function. The acute treatment of rat pinealocytes with VIP caused in their biochemical parameters. The present study concerns the effects of the chronic treatment with VIP on ultrastructure and function of the rat pinealocytes in organ culture. The pineals of adult male rats were assigned to one of three groups and placed in organ culture for four consecutive days. The pineals of the first group were incubated in the control medium, the pineals of the second group - 12 hrs in control medium and 12 hrs in medium with 1 ćM VIP (between 20.00 and 8.00) during each day, the pineals of the third group - 24 hrs per day in medium with 1 ćM VIP. The melatonin concentration was measured using RIA and activity of enzymes using radiochemical methods. Point count method was used in quantitative ultrastructural analysis. Both modes of chronic treatment with VIP increased significantly the level of melatonin secretion during four days of the culture and the content of this hormone in the pineal explants at the end of the experiment. Treatment with the neuropeptide for 12 hrs and 24 hrs per day elevated also the activity of arylalkylamine N-acetyltransferase and hydroxyindole=O-methyltransferase. On the other hand. VIP had no effect on the activity of arylamine-N-acetyltransferase. VIP increased the relative volume of rough endoplasmic reticulum. Golgi apparatus and mitochondria and did not influence the relative volume of lysosomes and lipid droplets as well as the numerical...

220/2523

Tytuł oryginału: Noradrenergic and peptidergic innervation of the mammary gland in the immature pig.
Autorzy: Franke-Radowiecka Amelia, Kaleczyc Jerzy, Klimczuk Magdalena, Łakomy Mirosław
Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.17-25, il., tab., bibliogr. 41 poz.
Sygnatura GBL: 304,846

Hasła klasyfikacyjne GBL:

ginekologia i położnictwo

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

Świnie

płeć żeńska

Streszczenie angielskie: The presence and pattern of coexistence of some biologically active substances in nerve fibres supplying the mammary gland in the immature pig were studied using immunohistochemical methods. The substances studied included: protein gene product 9.5 (PGP), tyrosine hydroxylase (TH), somatostatin (SOM), neuropeptide Y (NPY), galanin (GAL), calcitonin gene-related peptide (CGRP) and substance P (SP). The mammary gland was found to be richly supplied by PGP-immunoreactive (PGP-IR) nerve fibres that surrounded blood vessels, bundles of smooth muscle cells and lactiferous ducts. The vast majority of these nerves also displayed immunoreactivity to TH. Immunoreactivity to SOM was observed in a moderate number of nerve fibres which were associated with smooth muscles of the nipple and blood vessels. Immunoreactivity to NPY occurred in many nerve fibres associated with blood vessela and in single nerves supplying smooth muscle cells. Solitary GAL-IR axons supplied mostly blood vessels. Many CGRP-IR nerve fibres were associated with both blood vessels and smooth muscles. SP-IR nerve fibres richly supplied blood vessels only. The colocalization study revealed that SOM, NPY and GAL partly colocalized with TH in nerve fibres supplying the porcine mammary gland.

221/2523

Tytuł oryginału: Immunohistochemical localization of the somatostatin receptor subtype 2A in the rat adrenal gland.
Autorzy: Pisarek Hanna, Pawlikowski Marek
Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.27-30, il., bibliogr. 15 poz.
Sygnatura GBL: 304,846

Hasła klasyfikacyjne GBL:

endokrynologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie angielskie: The immunohistochemical localization of the somatostatin receptor subtype sst2A was investigated in the rat adrenal gland using SS-800 polyclonal antibody. The ss2A immunopositivity was found in all adrenocortical zones and in adrenal medulla, the reaction being slightly more intense in zona glomerulosa and medulla. The administration of the potent agonist of sst2 receptors - octreotide - resulted in the enhancement of the immunopositivity in zone glomerulosa and medulla, whereas chronic exposure of the rats to diethylstilbestrol led to enhancement of the immunopositivity in zone glomerulosa and in the external part of zona fasciculata.

222/2523

Tytuł oryginału: The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells.
Autorzy: Jakubowicz-Gil Joanna, Paduch Roman, Gawron Antoni, Kandefer-Szerszeń Martyna
Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.31-35, il., bibliogr. 36 poz.
Sygnatura GBL: 304,846

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Heat shock protein 27 (Hsp27) belongs to the group of proteins called molecular chaperones protecting normal and tumour cells against many stressors such as hyperthermia, several commonly used chemotherapeutics as well as other apoptotic stimuli. Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions. Our results indicate that Hsp27 expression is drug- and cell-type specific and depends on the culture model as well. HeLa, Hep-2 and HSF cell cultured in 3D model appeared to be more resistant to stimulatory or inhibitory effects of the applied drugs than cells cultured in 2D model. Only A549 cells cultured in 3D culture model appeared to be more susceptible and reacted to drugs and heat treatment with increased Hsp27 expression.

223/2523

Tytuł oryginału: Immunohistochemical assay of p53, cyclin D1, c-erbB2, EGFr and Ki-67 proteins in HPV-positive and HPV-negative cervical cancers.
Autorzy: Kędzia Witold, Schmidt Marcin, Frankowski Andrzej, Spaczyński Marek
Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.37-41, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 304,846

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The purpose of the present study was to analyse clinical correlation between HPV type 16 and 18 infection, expression of p53, cyclin D1, Ki-67, c-erbB2 and EGFr gene products in cervical cancer cells as well as their nuclear ploidy. The morphological parameters evaluated, such as differentiation of carcinomas, vascular invasion, ploidy and expression of oncogenic proteins, indicate the increased biological malignancy of HPV 16/18-positive carcinomas. The majority of them were poorly differentiated revealed significantly higher frequence of vascular invasion (p 0.05), were more frequently aneuploid and showd overexpression of cyclin D1. The comparison of the data obtained with the mortality rate of the patients suggests that the overexpression of EGFr and moderate expression of Ki-67 seem to be unfavorable prognostic factors, regardless of the presence of HPV 16/18.

224/2523

Tytuł oryginału: Molecular basis of the pathogenicity of Proteus bacteria.
Tytuł polski: Molekularne podstawy chorobotwórczości bakterii z rodzaju Proteus.
Autorzy: Różalski Antoni
Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.3-18, il., tab., bibliogr. 75 poz., streszcz.
Sygnatura GBL: 313,451

Hasła klasyfikacyjne GBL:

urologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie polskie: Bakterie Gram-ujemne z rodzaju Proteus, zaliczane do rodziny Enterobacteriaceae, są patogenami warunkowo-chorobotwórczymi, powodującymi m.in. zakażenia ran i układu moczowego (zakażenia dróg moczowych - urinary tract infections - UTI). Te ostatnie przebiegają z powikłaniami w postaci ostrego lub przewlekłego odmiedniczkowego zapalenia nerek i powstawania kamieni moczowych w pęcherzu i nerkach. Bakterie Proteus sp. są mikroorganizmami dimorficznymi, rosnąc na podłożu płynnym, stanowią krótkie pałeczki, tzw. komórki pływające, o długości 1 - 2 ćm, peritrychalnie urzęsione z 6 - 10 rzęskami na komórce. Po przeniesieniu na podłoże stałe komórki te różnicują się do długich form, wielkości 20 - 80 ćm, tzw. swarmer cells, z wieloma nukleoidami, nieprzedzielonymi przegrodami, ze zwiększoną nawet 500 razy liczbą rzęsek. Obie odmienne morfologicznie formy komórek Proteus, krótkie pałeczki i "swarmery" odgrywają rolę w chorobotwórczości, te ostatnie zwłaszcza w zakażeniach wstępujących, częściej powodowanych przez Proteus sp. Dotychczas zidentyfikowano następujące właściwości i czynniki chorobotwórczości tych bakterii: zjawisko rozpełzliwego wzrostu, fimbrie i glikokaliks odpowiedzialne za przyleganie, rzęski, właściwości inwazyjne, ureazę, deaminazy aminokwasów, proteazy, hemolizyny, polisacharyd powierzchniowy (CPS) i lipopolisacharyd (LPS, endotoksyna). Dyskutowane są ich genetyczna determinacja, podstawy molekularne i rola w chorobotwórczości Proteus sp.

Streszczenie angielskie: Gram-negative bacteria of the genus Proteus from the family Enterobacteriaceae are opportunistic pathogens, which cause mainly wounds and urinary tract infections (UTI), the latter leading to severe complications, such as acute or chronic pyelonephrithis and formation of bladder and kidney stones. Proteus are dimorphic bacteria. When grown in a liquid medium, they are motile, peritrichously flagellated short rods, referred to as swimmer cells 1.0 to 2.0 ćm in length, with 6 - 10 flagella per cell. When transferred to a solid medium, Proteus short bacilli differentiate to swarmer cells, which are multinucleated, nonseptated cells 20 - 80 ćm in length containing even 500 fold more flagella. Both, short rods and long swarmer cells, are important in the pathogenesis of bacteria, the latter being particularly important in ascending UTI, which are more common for Proteus strains. Virulence factors and properties of Proteus sp. mediating infectious process are swarming phenomenon, adherence due to the fimbriae or glycocalyx, flagell, invasiveness, urease, amino acids deaminases, proteases, hemolysins, capsular polysaccharide (CPS), and lipopolysaccharide (LPS, endotoxin). The genetic determination, molecular basis, and the pathophysiological role of these factors in the infections caused by Proteus sp., are discussed.

225/2523

Tytuł oryginału: Late results of a phase-I trial for immunotherpay of pancreatic cancer.
Tytuł polski: Późne wyniki pierwszej fazy badań nad immunoterapią raka trzustki.
Autorzy: Waleczek Helfried, Lukenheimer Holger, Gerhards Roswitha, Werchau Hermann, Kozuschek Waldemar
Opracowanie edytorskie: Knast Witold (koment.).
Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.19-24, il., bibliogr. 25 poz., streszcz.
Sygnatura GBL: 313,451

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Wprowadzenie. Na powierzchni komórek raka znajdują się antygeny swoiste dla rodzaju guza. W terapii nowotworu mogą więc znależć zastosowanie reakcje immunologiczne podobne do tych, jakie występują podczas procesu odrzucania przeszczepu. Wyniki leczenia raka trzustki są złe, nawet w przypadkach resekcji radykalnej. Terapia immunologiczna stanowi szansę na poprawę tych złych warunków. Cel pracy. Celem pracy była odpowiedź na pytanie, czy indywidualna odpowiedź immunologiczna może zostać pobudzona przez szczepionkę z zastosowaniem inaktywowancyh komórek raka zakażonych wirusem choroby Newcastle (NDV) pochodzących z autologicznych kultur komórek raka. Przedstawiono efekty kliniczne pierwszej fazy badań. Omówono również najnowsze piśmiennictwo poświecone badaniom z tej dziedziny (od 1995 r.). Materiał i metoda. Dziewięciu pacjentów zostało poddanych pełnej immunizacji po radykalnych operacjach z powodu raka trzustki wykonanych w latach 1992 - 1995. Hodowle komórkowe były prowadzone indywidualnie, jako kultury autologiczne, zostały zakażone NDV i inaktywowane odpowiednio do swej chemowrażliwości. Po zakończeniu pełnego szczepienia pacjentów miejsca odczynu skórnego na niezmodyfikowany materiał autologiczny guza wycinano i poddano badaniom immunohistochemicznym. Badania objęły okres do 2001 r. Wyniki. U wszystkich pacjentów stwierdzono indukcję lub wzmożenie nadwrażliwości typu późnego na autologiczny materiał guza. Reakcji tej nie odnotowano w stosunku do nieswoistych ...

Streszczenie angielskie: Background. Carcinoma cells present tumorspecific antigens on their cell surfaces. Thus immunological reactions similar to transplant rejections may be induced and used in tumor therapy. Results of therapy for cancer of the pancreas are still very poor even after complete resection. Immunological approaches may improve patients outcome. Objectives. The aim of the study was to determine whether an individual immunological response could be induced by vaccination with Newcastle Disease Virus (NDV) infected inactivated cancer cells from autologous tumor cell cultures. Clinical effects of a phase I trial were recorded. New insights since 1995 are discussed. Material and methods. 9 patients could be immunized completely after curative resection fo adenocarcinomas of the pancreas between 1992 and 1995. Tumors were grown individually as autologous cell cultures, NDV infected and inactivated according to their chemosensitivity. After complete vaccination patients reaction sites to unmodified autologous tumor material were resected and tested by immunohistochemistry. Clinical outcome up to 2001 was recorded. Results. All patients showed induction or inhancement of delayed type hypersensitivity to autologous tumor amterial but not to unspecific markers. No patient showed vaccination site skin metastasis development. No hepatic metastasis occurred in the vaccination group. 7 of these patients died due to local (retroperitoneal) tumor growth. 2 patients have no recurrent tumor ...

226/2523

Tytuł oryginału: GSTT1 and GSTM1 polymorphism in patients with the carcinoma laryngis.
Tytuł polski: Polimorfizm genów GSTT1 i GSTM1 u pacjentów chorych na raka krtani.
Autorzy: Schlade-Bartusiak Kamilla, Zych Monika, Kręcicki Tomasz, Sąsiadek Maria
Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.25-27, tab., bibliogr. 14 poz., streszcz.
Sygnatura GBL: 313,451

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: Wprowadzenie. W etiologii dużą rolę odgrywają czynniki środowiskowe (głównie palenie papierosów i spożywanie alkoholu), ale jedynie u około 10 - 15 proc. palaczy występuje ten typ nowotworu. Zdeterminowana genetycznie podatność na powstawanie HNSCC może zależeć od aktywności metabolicznej enzymów detoksyfikujących karcinogeny obecne w dymie tytoniowym. Jedną z grup takich enzymów jest wielogenowa rodzina transferaz S-glutation. Geny GSTT1 i GSTM1 charakteryzują się polimorfizmem, który można wykryć, jeśli delecji ulegają obie kopie genu. Cel pracy. Celem pracy było zbadanie częstości delecji genów GSTT1 i GSTM1 u pacjentów z HNSCC w porównaniu z populacją kontrolną. Materiał i metody. Polimorfizm genów GSTT1 i GSTM1 badano technika PCR u 40 pacjentów chorych na raka krtani i u 77 osób z grupy kontrolnej. Wyniki. Nie stwierdzono znaczącej statystycznie różnicy między częstością delecji badanych genów u pacjentów z HNSCC w porównaniu z grupą kontrolną. Wnioski. Otrzymane wyniki sugerują brak wpływu delecji badanych genów na częstość występowania HNSCC.

Streszczenie angielskie: Background. Environmental factors (mainly cigarette smoking and alcohol consumption) play an important role in eatiology of head and neck squamous cell carcinoma (HNSCC), but only about 10 - 15 p.c. of heavy smokers develop this type of cancer. Genetically determined susceptibility to HNSCC may depend on the metabolic activity of enzymes that detoxify carcinogens present in tobacco smoke. One group of these enzymes is a multigene family of glutathione S-transferases. The GSTT1 and GSTM1 genes are known to be polymorphic. Polymorphic forms resulting from gene deletion are characterized by the lack of a detectable gene and are called null genotypes. Objectives. The aim of the present study was to investigate the frequency of GSTT1 and GSTM1 null genotypes in HNSCC patients in comparison to a control population. Material and methods. The PCR-based analysis of GSTT1 and GSTM1 polymorphism was done in the group of 40 cancer patients and 77 healthy controls. Results. Our results show no statistically significant difference in the distribution of GSTM1 and GSTT1 genotypes between the tested groups. Conclusions. The results are in agreement with the studies of other authors suggesting no involvement of the GSTM1 or GSTT1 null genotypes in the risk of HNSCC.

227/2523

Tytuł oryginału: Principal component analysis of patient variables as an objective method of treatment evaluation in adolescent idiopathic scoliosis.
Tytuł polski: Analiza składników głównych jako obiektywny sposób oceny leczenia skoliozy idiopatycznej.
Autorzy: Buciński Adam, Kowalski Ireneusz M., Zarzycki Daniel, Bączek Tomasz, Nasal Antoni, Kaliszan Roman
Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.61-68, il., tab., bibliogr. 16 poz., streszcz.
Sygnatura GBL: 313,451

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Wprowadzenie. Analiza składników głównych (PCA - principal component analysis) została wykorzystana do oceny strategii terapeutycznej leczenia skoliozy idiopatycznej. Analiza PCA została przeprowadzona na dużym zbiorze wskaźników klinicznych. Metoda pozwoliła na ocenę złożonych zależności między zmiennymi charakteryzującymi pacjentów, chorobę i postępowanie terapeutyczne. Materiał i metody. Studia przeprowadzono na grupie 294 pacjentów, których charakteryzowały 137 zmienne. Wszystkich pacjentów poddano standardowej procedurze rehabilitacyjnej, przy czym 180 z nich było dodatkowo leczonych metodą elektrostymulacji LESS (lateral electrical surface stimulation). Macierz 137 zmiennych x 294 przypadki została poddana analizie składników głównych za pomocą programu Statistica (StatSoft Inc., Tulsa, OK, USA). Wyniki. Wyekstrahowane trzy składniki główne, PC1, PC2 i PC3 opisały 13 proc. całkowitej zmienności próby. Wyraźne zróżnicowanie położeń punktów w przestrzeni wyznaczonej przez trzy pierwsze składniki główne interpretowano w kategoriach podobieństw (różnic) między przypadkami. Wnioski. Wykazano, że postępowanie terapeutyczne włączające elektrostymulację LESS pozytywnie wpływa na leczenie skoliozy idiopatycznej.

Streszczenie angielskie: Background. An advanced multivariate data processing method, principal component analysis (PCA), was demonstrated to provide an objective evaluation of treatmetn strategy by making use of large collections of routine clinical parameters of adolescent idiopathic scoliosis patients. The method allowed for detection of complex systematic relationships between diverse patient, disease and treatment variables. Material and methods. Two hundred ninety four patients with adolescent idiopathic scoliosis were the subject of the study for whose one hundred thirty seven disease and treatment variables were determined. It was revealed by PCA that a lateral electrical surface stimulation (LESS) treatment positively affected the outcome of adolescent idiopathic scoliosis. A matrix of 294 x 137 data points was analyzed by PCA employing a commercially available statistical softwar and a personal computer. All the 294 patients underwent standard rehabilitation procedure and 180 of them were subjected additionally to LESS treatment. Results. Three principal components, PC1, PC2 and PC3, were extracted which accounted cumulatively for 13 p.c. of the variance of the data analyzed. An apparent clustering of the variables and a clear cut clustering of the patients were observed, which have been interpreted in terms of similarity (dissimilarity) of the variables and of the patients. Principal component analysis has been recommended as a new promising altlernative to classical regression analysis of multivariable clinical data. By means of PCA practically useful systematic information may be extracted from large sets of data otherwise hardly interpretable in comphrehensive physical terms...

228/2523

Tytuł oryginału: Remnants of respiratory peaks in heart rate variability spectrum of an adult man with tachypnea and bradycardia.
Tytuł polski: Pozostałości pików oddechowych w widmie zmienności rytmu serca dorosłego człowieka z szybkim rytmem oddechowym i wolnym rytmem serca.
Autorzy: Sacha Jerzy, Grzeszczak Władysław
Źródło: Folia Cardiol. 2002: 9 (1) s.67-74, il., bibliogr. 9 poz., streszcz.
Sygnatura GBL: 313,196

Hasła klasyfikacyjne GBL:

kardiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć męska

Streszczenie polskie: Analiza zmienności rytmu serca (HRV) w dziedzinie częstotliwości jest użytecznym narzędziem do badania fluktuacji rytmu zatokowego powodowanych przez autonomiczny układ nerwowy. Jednakże, nie jest jasne, jaka jest górna granica częstotliwości, która może być analizowana w widmie HRV. Materiał i metody: Badamy widma HRV dorosłego ochotnika z szybkim rytmem oddechowym, gdy jego rytm jest zwalniany bądź przyspieszany. Stosując szybką tranformatę Fouriera (FFT), analizujemy serie odstępów między uderzeniami serca w dziedzinie częstotliwość. Przeprowadzamy również komputerowe symulacje mierzonych sygnałów i porównujemy otrzymane z widmiami ochotnika. Wyniki: Jeżeli częstość oddechów przekracza połowę średniej częstości uderzeń serca, w widmie HRV są obecne dwa piki reprezentujące ten sam sygnał oddechowy. Jeden z pików jest wynikiem zjawiska aliasingu, natomiast drugi jest pozostałością prawdziwego piku oddechowego, jako efekt właściwości symetrii FFT. Żaden z nich nie przynosi rzetelnej, ilościowej informacji o fali oddechowej w widmie HRV. Wnioski: Górna granica częstotliwości w widmie HRV jest zdeterminowana przez połowę średniej częstotliwości serca. Przed obliczaniem widma należy więc określic górny możliwy do analizy limit częstotliwości, by uniknąć sytuacji, w której analizowane zakresy lokalizują się poza tą granicą. Sytuacja jest taka wielce prawdopodobna w przypadku, gdy pacjent wykazuje wolną akcję serca.

Streszczenie angielskie: Introduction: Heart rate variability (HRV) analysis in frequency domain is a useful tool to investigate fluctuations of the sinus rhythm caused by the nervous system. However, it is not clear what the upper limit of the frequency where the HRV spectrum is reliable is. Material and methods: We investigated HRV spectra of an adult man with high respiratory rate when his heartbeat rate was slowed down or accelerated. We applied Fast Fiurier Transform (FFT) to analyse the discrete event series in the frequency domain. We also performed numerical simulations of measured signals and compared the resulting spectra with those of the man. Results: It the respiration rate exceeds half of the average heartbeat rate, two peaks corresponding to the same respiratory signal can be found in the spectrum. One of them results from the aliasing phenomenon but the other is a remnant of the true respiratory peak whose origin lies in the symmetry properties of FFT. None of the peaks brings reliable, quantitative information about the respiration wave in the HRV spectrum. Conclusion: The upper frequency limit in a hRV spectrum is determined by half of the average heartbeat frequency. Consequently, one should check if any considered fluctuation lies within this frequency range, otherwise there is no reliable information about the fluctuation in the HRV spectrum. Such a situation is likely to occur when a patient exhibits slow heart rate.

229/2523

Tytuł oryginału: Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum.
Autorzy: Błaszkowska Joanna
Źródło: Wiad. Parazytol. 2002: 48 (1) s.55-64, il., tab., bibliogr. [33] poz.
Sygnatura GBL: 303,658

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zarodki

ptaki

Streszczenie angielskie: It has been found that trypsin and ŕ-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn chicken embryos. Mortality rate for the chicken embryos on day 15 of incubation was 45.0 ń 3.5 p.c. after injection of trypsin inhibitor and 44.0 ń 3.5 p.c. after adminstration ŕ-chymotrypsin inhibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformationsd was foundf after administration of ŕ-chymotrypsin inhibitor. The most commonly occurring abnormality was schistocelia (21.4 ń 3.88 p.c.). Growth malformations were not found in the control groups. The trypsin and ŕ-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on ther development of the chicken embryo.

230/2523

Tytuł oryginału: Sprawozdanie z II Międzynarodowej Konferencji "A Sound fundation through early amplification", Chicago 6-10.XI.2001.
Autorzy: Obrębowski Andrzej
Źródło: Otolaryngol. Pol. 2002: 56 (2) s.275-276 - 2 Międzynarodowa Konferencja pt. Wczesna amplifikacja dżwięku Chicago 08-10.11. 2001
Sygnatura GBL: 313,466

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

sprawozdanie

tytuł obcojęzyczny

Wskaźnik treści:

231/2523

Tytuł oryginału: Hypoxic-ischemic encephalopathy: pathophysiology and implications for therapy.
Tytuł polski: Encefalopatia niedotlenieniowo-niedokrwienna u noworodków.
Autorzy: Sunshine Philip
Źródło: Prz. Lek. 2002: 59 supl. 1: Międzynarodowa konferencja "Postępy w neonatologii" s.6-9, bibliogr. 37 poz., streszcz. - Międzynarodowa konferencja pt. Postępy w neonatologii Kraków 18-20.04. 2002
Sygnatura GBL: 310,563

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

noworodki

Streszczenie polskie: Encefalopatia niedotlenieniowo-niedokrwienna u noworodków wciąż jest ważnym problemem medycznym z uwagi na dużą śmiertelność, a także występujące u przeżywających niemowląt następstwa neurologiczne i upośledzenie intelektualne. Oprócz początkowej ostrej martwicy neuronów, wtórne ich uszkodzenie spowodowane reperfuzją dokonuje się przez 6 do 72 godzin od pierwotnego urazu. Wtórna niedomoga energetyczna komórek, rozpad błon komórkowych, dokomórkowy napływ jonów wapnia, produkcja cytokin oraz oksydacja przekaźnikowych aminokwasów - wszystko to przyczynia się do przyspieszonej i wzmożonej apoptozy neuronów. Nowe metody leczenia, takie jak stosowanie inhibitorów wolnych rodników tlenowych oraz utrzymywanie przez pierwsze 72 godziny życia łagodnej lub umiarkowanej hipotermii ogólnoustrojowej lub wybiórczej hipotermii głowy są obiecującymi środkami pomocniczymi w postępowaniu z noworodkami z encefalopatią niedotlenieniowo-niedokrwienną.

Streszczenie angielskie: Hypoxic-ischemic encephalopathy continues to be a major problem in perinatal medicine because of the high mortality rate and neurological and intellectual imparment in the surviving infants. In addition to the acute necrotic damage that occurs in the neurons initially, reperfusion injury and secondary neuronal damage continue for 6 to 72 hours after the initial insult. Secondary cellular energy failure, membrane breakdown, cellular influx of calcium ions, elaboration of cytokines, and oxidation of excitory amino acids all contribute to enhanced apoptosis of the neurons. Newer forms of therapy including the use of oxygen-free radical inhibitors and mild to moderate cerebral or systemic hypothermia for 72 hours following the asphyxial period are promised adjuncts as follow-up approaches to the affected newborns.

232/2523

Tytuł oryginału: Status report: inhaled nitric oxide in persistent pulmonary hypertension/hypoxic respiratory failure of neonate.
Tytuł polski: Zastosowanie tlenku azotu w leczeniu zespołu zaburzeń oddychania oraz przetrwałego nadciśnienia płucnego noworodków.
Autorzy: Cook Larry N.
Źródło: Prz. Lek. 2002: 59 supl. 1: Międzynarodowa konferencja "Postępy w neonatologii" s.10-13, bibliogr. 50 poz., streszcz. - Międzynarodowa konferencja pt. Postępy w neonatologii Kraków 18-20.04. 2002
Sygnatura GBL: 310,563

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

noworodki

Streszczenie polskie: Przetrwałe nadciśnienie płucne noworodków (PPHN) może być obserwowane w przebiegu różnych zaburzeń, w tym m. in. u dzieci z ciężką zamartwicą, zespołem aspiracji smółki, posocznicą wywołaną przez paciorkowce grupy B lub też u chorych z wadami wrodzonymi jak np. wrodzoną przepukliną przeponową. W pierwszej części omówiono stosowanie standardowych metod leczenia jak również użyteczność podawania surfaktantu i wentylacji wysokimi częstotliwościami u noworodków z PPHN. Następnie przedstawiono zasadę działania wziewnego tlenku azotu (iNO) oraz oceniono wyniki badń klinicznych na temat skuteczności tlenku azotu u noworodków z PPHN. Omówiono nowe kierunki badawcze, w tym stosowanie iNO u wcześniaków z zespołem zaburzeń oddychania oraz możliwości wykorzystanmia iNO w profilaktyce przewlekłej choroby płuc u wcześniaków. Przedstawiono aktualne zalecenia na temat dawkowania iNO u noworodków oraz aktualnie opublikowane wytyczne Amerykańskiej Adakemii Pediatrii na temat stosowania iNO u noworodków. W ostatniej części dokonano przeglądu dostępnych badań klinicznych oceniających odległe wuniki leczenia iNO u noworodków.

Streszczenie angielskie: Presistent pulmonary hypertension is seen in association with a number of diseases and conditions in the newborn including perinatal asphyxia, meconium aspiration syndrome, Group B strep sepsis, and certain surgical conditions such as congenital diaphragmatic hernia. The conventional therapy of persistent pulmonary hypertension is discussed as well as the adjunctive role of surfactant replacement therapy and high frequency ventilation. The mechanisms of action of inhaled nitric oxides as a selective pulmonary vasodolator is explained. Human neonatal clinical experience is chronicled from the original studies of Roberts in 1992 and Kinsella in 1993. A review of three large prospective randomized trials of nitric oxides is presented as well as a summary of new areas of investigation including the use of nitric oxide in pre-term infants and the use of nitric oxide in the prevention of chronic disease. Current dosing recomendations are presented as well as guidelines recently published from the American Academy of Pediatrics. A review of follow up literature in relationship to patients receiving inhaled nitric oxides is also summarized.

233/2523

Tytuł oryginału: T type 1/type 2 subsets balance in B-cell chronic lymphocytic leukemia - the three-color flow cytometry analysis.
Autorzy: Podhorecka Monika, Dmoszyńska Anna, Roliński Jacek, Wąsik Ewa
Źródło: Leuk. Res. 2002: 26 (7) s.657-660, il., bibliogr. 8 poz.
Sygnatura GBL: 306,151

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie angielskie: The impairments in immune cell functions as well as changes in cytokine network are the cause of malignant cell accumulation and secondary immune deficiencies in B-cell chronic limphocytic leukemia (B-CLL). To broaden the knowledge of immune system in B-CLL we tried to evaluate the Th1/Th2 and Tc2 balance in B-CLL patients in comparison with healthy individuals and changes of this pattern during disease progression. The three-color flow cytometry technique was used to analyze IL-4 and IFNç expression in peripheral blood CD3+CD4+ and CD3+CD8+ cells. The results indicate the dominance of T type 1 cells and T-cell-mediated immunity in B-CLL patients that is however shifted towards T type 2 during disease progression.

234/2523

Tytuł oryginału: Morphine attenuates pain and prevents inflammation in experimental peritonitis.
Autorzy: Płytycz Barbara, Natorska Joanna
Źródło: Trends Immunol. 2002: 23 (7) s.345-346, il., bibliogr. 13 poz.
Sygnatura GBL: 312,774

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

235/2523

Tytuł oryginału: Primenenie mediastinoskopii w diagnostike khirurgicheskikh zabolevanij organov grudnoj polosti.
Tytuł angielski: Application of mediastinoscopy in diagnosis of surgical diseases of the thoracic cavity organs.
Autorzy: Pieluchowski S. W.
Źródło: Klin. Khir. 2002 (1) s.58-59, bibliogr. 5 poz.
Sygnatura GBL: 303,753

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

236/2523

Tytuł oryginału: Oslozhnenija posle operacij s primeneniem videotorakoskopii i ikh lechenie.
Tytuł angielski: Complications after operation with videothoracoscopy application and their treatment.
Autorzy: Pieluchowski S. W., Piwkowskij C., Kasprzak P.
Źródło: Klin. Khir. 2002 (2) s.30-31, bibliogr. 6 poz., sum.
Sygnatura GBL: 303,753

Hasła klasyfikacyjne GBL:

pulmonologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: Of 4715 patient, who were present in 1995-2000 yrs in the clinic, in 708 (15 p.c.) operation, using videothoracoscopy method, was performed. In 539 (76.1 p.c.) of patietns the method was applied for diagnosis and in 169 (23.9 p.c.) - for treatment. After the operation 365 patients were observed, complications have occurred in 14, including the early - in 10 (2.7 p.c.) and the late - in 4 (1.1 p.c.). All the patients have survived.

237/2523

Tytuł oryginału: Analysis of Ixodes ricinus (L.) tick burdens in a resident passerine bird community in the Mazurian Lake region (Northeastern Poland).
Autorzy: Gryczyńska Alicja, Barkowska Miłosława, Siemiątkowski Marek
Źródło: Acta Parasitol. 2002: 47 (1) s.51-57, il., tab., bibliogr. [32] poz.
Sygnatura GBL: 303,018

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: The abundance of birds and their tick parasites were estimated in a residential avian community located in the Mazurian Lake region (NE Poland). A total of 1624 passerine birds (representing 45 species) were captured, of which 25 p.c. were infested with at least one tick. All the ticks belonged to the species Ixodes ricinus. The highest tick infestation prevalence ( 50 p.c.) were recorded for dunnock (Prunella modularis), tree pipit (Anthus trivialis), hawfinch (Coccothraustes coccothraustes) and blackbird (Turdus merula). Changes in tick infestation prevalence of passerine birds are seasonal. June and September were the two months in which tick infestation rates were the highest. The percentage of birds that were tick carriers was significantly greater in mixed coniferous forest than in alder swamp forest (respectively 32 p.c and 20 p.c. of birds were infested with ticks).

238/2523

Tytuł oryginału: Experimental Chagas'disease: the protection induced by immunization with Trypanosoma rangeli is associated with down-regulation of IL-6, TNF-ŕ and IL-10 synthesis.
Autorzy: Cervetta Liliana, Moretti Edgardo, Basso Beatriz
Źródło: Acta Parasitol. 2002: 47 (1) s.73-78, il., bibliogr. [36] poz.
Sygnatura GBL: 303,018

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: In an experimental model developed in our laboratory, BALB/c mice were protected against Trypanosoma cruzi infection by immunization with T. rangeli, a parasite closely related to T. cruzi but not pathogenic for man. Immunized mice developed low parasitemia and high survival rates when challenged with T. cruzi. In the present work, we study the patterns of systemic production of interleukin (IL-6), tumor necrosis factor alfa (TNF-ŕ), interferon gamma (IFN-ç), IL-2, IL-4 and IL-10 during the acute phase of T. cruzi infection in mice previously immunized with T. rangeli with respect with respect to only infected mice. The results showed a concentration of IL-6, TNF-ŕ and il-10 significantly lower in immunized mice than in only infected ones. The production of IFN-ç, a cytokine involved in resistance, was preserved in vaccinated mice. Finally, both groups of animals showed IL-2 and IL-4 serum levels similar to those observed in uninfected mice. As in other experimental or human infections, in this model, the pattern of systemic production of cytokines can be associated with the outcome of infection.

239/2523

Tytuł oryginału: A new automatized fluorometric assay for anti-Leishmania drug screening.
Autorzy: Le Pape Patrice, Pagniez Fabrice, Abdala Hiam
Źródło: Acta Parasitol. 2002: 47 (1) s.79-81, il., tab., bibliogr. [11] poz.
Sygnatura GBL: 303,018

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

tytuł obcojęzyczny

Streszczenie angielskie: The therapeutic armentarium against leishmaniasis is very restricted, using mainly up to now drugs showing several side effects and resistance. Consequently, there is a real need to find new compounds as alternatives for the treatment of leishmaniasis. However, most of the classic antileishmanial primary screening assays are not suitable for measuring the cytotoxicity of large number of drug candidates because of the manipulation required. we have established a new assay that incorporate a fluorometric growth indicator based on the detection of a metabolic activity in culture medium after the chemical reduction of alamar Blue by cells. This antileishmanial test was evaluated on amphotericin B. meglumine antimoniate, allopurinol, ketoconazole and edelfosine. The results reported show the advantages of this fluorochrome on the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) for Leishmania cytotoxicity measurement. Moreover, this study is the first report of the use of alamar Blue flurogenic assay for activity assessment of potential antileishmanial drugs against promastigotes.

240/2523

Tytuł oryginału: Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock.
Autorzy: Luchowska Elżbieta, Luchowski Piotr, Wielosz Marian, Kleinrok Zdzisław, Czuczwar Stanisław J., Urbańska Ewa M.
Źródło: Pharmacol. Biochem. Behav. 2002: 71 (1/2) s.223-231, il., tab., bibliogr. [40] poz.
Sygnatura GBL: 312,498

Hasła klasyfikacyjne GBL:

farmacja

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

myszy

Streszczenie angielskie: The anticoconvulsive potential of classical antiepileptics co-administered with á-adrenergic receptor antagonists against generalized tonic-clonic seizures was evaluated in the model of maximal electroshock (MES)-induced convulsions. Propranolol, acebutolol, metoprolol and atenolol were tested in the doses not affecting the electroconvulsive threshold. Propranolol and metoprolol lowered the ED50 of valproate and diazepam. Acebutolol reduced valproate's but not diazepam's ED50 value. In contrast, hydrophilic atenolol, not penetrating via blood-brain barrier, affected neither the action of valproate nor diazepam. None of the studied drugs changed the protective activity of carbamazepine and phenytoin against MES. á-blokers per se did not alter the motor performance of mice. Moreover, propranolol and metoprolol did not influence diazepam-evoked impairment of locomotor activity. The free plasma and brain levels of antiepileptic drugs were not affected by á-blokers. In conclusion, the use of certain á-adrenoceptor antagonists, such as propranolol and metroprolol, might improve the antiepileptic potential of valproate and diazepam.

241/2523

Tytuł oryginału: Sarcal nerve modulation for fecal incontinence. Functional results and assessment of the quality of life.
Tytuł polski: Pobudzenie nerwów krzyżowych w leczeniu nietrzymania stolca. Ocena wyników czynnościowych i jakości życia.
Autorzy: Ganio E[nzo], Luc Realis A., Ratto C., Doglietto G. B., Masin A., Dodi G., Altomare D. F., Memeo V., Rippeti V., Arullani A., Falletto E., Gaetini , Scarpino O., Saba V., Infantino A., La Manna S., Ferulano , Villani R.
Źródło: Proktologia 2002: 3 (2) s.121-126, il., bibliogr. 13 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Bezpośrednia stymulacja nerwu sromowego w sytuacji morfologicznie nieuszkodzonych zwieraczy odbytu stanowi atrakcyjną możliwość leczenia nietrzymania stolca, pozwalającą wykorzystać istniejący aparat zwieraczowy. Oceniano metodę bezpośredniej stymulacji korzeni krzyżowych pod kątem wykonalności, bezpieczeństwa, skuteczności i jej wpływu na jakość życia pacjentów. Badaniem objęto 116 pacjentów z nietrzymaniem stolca stałego i płynnego przynajmniej raz w tygodniu przez co najmniej 2 tygodnie, nie reagujących na leczenie konwencjonalne. W znieczuleniu miejscowym wprowadzono igłę do nakłucia lędźwiowego, którą następnie zastępowano czasowym przewodem stymulatora. Stymulacja nerwów powodowała ściśle określoną reakcję ruchową w zakresie krocza, zwieraczy, a także ruch nogi. U pacjentów poddanych stymulacji zaobserwowano poprawę funkcji zwieraczy, ze zmniejszeniem się liczby epizodów nietrzymania średnio z 11 do 3. Wśród 36 osób zakwalifikowanych do implantacji stymulatora na stałe liczba epizodów nietrzymania zmniejszyła się średnio z 15 do 3,3 w okresie 14 dni. Manometria anorektalna nie wykazała statystycznie znamiennych różnic. Uzyskano także poprawę w zakresie drobnych epizodów nietrzymania (popuszczanie gazu albo brudzenie bielizny), ze zmniejszeniem się ich liczby z 41,6 do 4,2. Wyniki tego badania dowodzą, że w wybranych przypadkach neuromodulacja krzyżowa stanowi nową i skuteczną metodę leczenia nietrzymania stolca. Po zastosowaniu symulatora stwierdzono również statystycznie znamienną korelację między poprawą wskaźników zdrowia psychicznego i somatycznego oraz poprawę stanu czynnościowego zwieraczy.

Streszczenie angielskie: Direct stimulation of the pudendal nerve in a morphologically intact anal sphincter is an attractive treatment option as it allows use of the anatomical existing sphincters. Method of direct stimulation of the sacral roots was evaluated according to feasibility, safety, effectiveness and its impact on the patient's quality of life. The study included 116 patients with incontinence to solid and liquid stool once a week for at least 2 preceding weeks, which did not respond to conventional treatments. A spinal needle was inserted under the local anesthesia or temporary stimulator lead was used to replace it. Stimulation of nerves resulted in specific motor responses of the perineum and sphincters along with movement of the leg. Among the patients who underwent perineal nerve evaluation, an improvement was observed in continence, with a decrease in the number of incontinent episodes from mean of 11 to 3 episodes. Of 36 who were selected for definitive implant incontinence episodes decreased from 15 to 3.3 per 14 days. Anorectal manometry did not show any statistical difference. Improvement in the episodes of minor incontinence (to gas and soliting) was also seen with reduction from 41.6 episodes to 4.2. The study demonstrates that sacral neuromodulation in selected patients represents a new and effective tool in treatment. There was also a significant correlation between the mental and physical health indices and continence status after the implant.

242/2523

Tytuł oryginału: Combined parasacral and perineal approach in the surgical treatment of the anal incontinence.
Tytuł polski: Skojarzone dojście kroczowe i okołokrzyżowe w leczeniu chirurgicznym nietrzymania stolca.
Autorzy: Korcek J., Bakos E., Klobusicky P.
Źródło: Proktologia 2002: 3 (2) s.127-132, il., tab., bibliogr. 14 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

chirurgia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie polskie: Na podstawie własnych doświadczeń anatomicznych i klinicznych, a także doświadczeń związanych z leczeniem chirurgicznym nietrzymania stolca o różnej etiologii autorzy wykazali skuteczność i praktyczną przydatność skojarzonego dojścia przykrzyżowo-kroczowego (CPAPP) w chirurgicznym leczeniu nietrzymania stolca. Autorzy przeprowadzili powtarzane pomiary końcowej latencji ruchowej nerwu sromowego (PN TML) u 23 pacjentów z wydłużeniem latencji przed zabiegiem. Po operacji u 82,6 proc. pacjentów uzyskano prawidłowe wyniki PN TML, co korelowało z pełną sprawnością zwieracza.

Streszczenie angielskie: In accordance with their own anatomic and clinical experiences as well as the experiences from the surgical therapy of various kinds of anal incontinence, the authors prove the expedience and effectiveness of the combined parasacral and perineal approach (CPAPP) in the surgical therapy of the anal incontinence. Authors performed a repetitive measuring the pudendal nerve terminal motor latency (PN TML) in the group of 23 patients with the pre-operative prolonged PN TML. 82.6 p.c. of the patients had postoperatively the normal values PN TML and this was in the correlation with the full continence.

243/2523

Tytuł oryginału: Pilonidal diseases: a review.
Tytuł polski: Torbiel włosowata kości ogonowej. Przegląd.
Autorzy: Casula G., Zorcolo L., Capra F., Scintu F.
Źródło: Proktologia 2002: 3 (2) s.133-139, tab., bibliogr. 80 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

traumatologia i ortopedia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Zatoka włosowata jest to ślepo zakończony przewód, o ścianach zbudowanych z ziarniny, zakończony jamą zawierającą włosy i złuszczony nabłonek. Może ona powodować znaczne kłopoty głównie u osób młodych, zarówno w skutek dyskomfortu, jak i straconego czasu pracy. Proponowano wiele różnych sposobów leczenia zatoki włosowatej, jednak większość z nich obarczona jest znacznym odsetkiem nawrotów. Są to różne metody - od prostego przyżegania, przez wstrzyknięcie fenolu, do złożonych zabiegów plastycznych. Największe prawdopodobieństwo powodzenia mają zabiegi chirurgiczne omijające linię środkową. Metoda Bascoma jest najprostszym sposobem uzyskania rany głównej poza linią środkową. Technika ta jest prosta i nadaje się do stosowania w warunkach "chirurgii jednego dnia" w znieczuleniu miejscowym. Daje też korzystne wyniki pod względem szybkiego powrotu do pracy i niewielkiego odsetka nawrotów. Autorzy uważają metodę Bascoma za metodę z wyboru w początkowym leczeniu objawowej zatoki włosowej. Asymetryczne wycięcie z pierwotnym zamknięciem skóry (zabieg Karidakiego) również stanowi korzystną alternatywę. Może być przeprowadzony w znieczuleniu miejscowym, jednak wiąże się z nieco większym odsetkiem powikłań i jest technicznie trudniejszy, ale ryzyko nawrotu jest tu mniejsze. Bardziej definitywna metoda, np. plastyka Z, jest zalecana u pacjentów z nawracającą i nie gojącą się raną w linii środkowej lub z nawracającą zatoką włosowatą.

Streszczenie angielskie: Pilonidal sinus is blind-end track lined with granulation tissue, which leads to a cavity containing hairs and skin debris. It is a considerable source of problems in young patients both in terms of discomfort and time of work. Many procedures have been proposed for its management but most of them carry substantial persistence/recurrence rates. Treatments vary from simple cauterization with fenol injection to complex plastic procedures. Surgical procedures avoiding a wound in the midline are most likely to succeed. Bascom's technique is the simplest method to keep the main wound away from the midline. The technique is simple and suitable for one-day surgery in local anasthesia. It also gives favorable results in terms of return to work and rate of recurrence. Authors consider Bacom's technique the procedure of choice in the initial treatment of symptomatic pilonidal disease. Asymmetric excision with primary closure (Karidaki's procedure) is also an attractive option. It can performed under local anasthesia, has a little higher complication rate and is more complex, however is characterized by a lower risk of reccurence. More definitive treatments such as Z-plasty is probably the best choice in patients with persistently unhealed midline wound or recurrent pilonidal sinus.

244/2523

Tytuł oryginału: Local excision of rectal cancer.
Tytuł polski: Miejscowe wycięcie raka odbytnicy.
Autorzy: Rosa G., Lolli P., Piccinelli D., Bonomo S., Brugnettini F.
Źródło: Proktologia 2002: 3 (2) s.140-142, bibliogr. 9 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Miejscowa resekcja jest możliwa jedynie u ok. 5 proc. pacjentów z rakiem odbytnicy, mimo widocznego ostatnio wzrostu zaintresowania tą metodą związanego z rozwojem nowych technik operacyjnych (m.in. TEM), rozszerzających możliwości działania chirurga i umożliwiających operowanie guzów zlokalizowanych nawet ponad 10 cm od brzegu odbytu. Kluczową sprawą pozostaje właściwe określenie wskazań, co z kolei determinuje wybór rodzaju operacji. Wskazania do miejscowej resekcji guza to: średnica guza nie przekraczająca 3 cm, guz egzofityczny (wyrasta do światła kanału odbytu), brak owrzodzeń, guz nie jest nieruchomy względem otoczenia, o niskiej złośliwości, zlokalizowany do 8 cm od brzegu odbytu (przy zastosowaniu metody tradycyjnej) albo do 12 cm na ścianie tylnej i do 15 cm na ścianie bocznej (przy zastosowaniu techniki TEM). Autorzy przeprowadzili 60 zabiegów miejscowej resekcji, z których 41 było zabiegiem definitywnym i dającym pełne wyleczenie. Pacjentów poddano ścisłej obserwacji przez 18 miesięcy, wykonując badania proktologiczne, proktoskopię, ultrasonografię transonalną oraz, w razie potrzeby, badania CT i MRI, a także rutynowe badania hematologiczne stosowane w onkologii. Dobre wyniki leczenia zależą od prawidłowego wyboru pacjentów z nowotworem w stadium T1, należących do grupy niskiego ryzyka.

Streszczenie angielskie: Local excision remains a limited practice concerning only 5 p.c. of rectal cancers despite the fact that it has been given a new attention with new instruments (TEM) to extended the range of action allowing to reach neoplasms located over 10 cm from anus. The main issue remains correct indications, which determines the operation. Elective indications for local excision include: diameter of the tumor less than 3 cm, tumor has to be exofitic, non-ulcerated, non-fixed, low malignancy, located up to 8 cm from anus in case of traditional and up to 12 cm on the posterior, 15 on the lateral by TEM techniques. Authors performed 60 local excisions. 41 of them were considered definitive and curative. Close follow up for 18 months include proctologic examination, proctoscopy, transanal ultrasound, CT, MRI if necessary, hematological oncological routine. Good results depend on rigorous selection of patients with T1 at lower risk.

245/2523

Tytuł oryginału: Ambulatory surgery - what we can be done on a one day surgery basis in proctology?
Tytuł polski: Chirurgia jednego dnia - jakie zabiegi mogą być wykonywane z zakresu proktologii?
Autorzy: Kosorok Pavle, Pokrajac Tatjana
Źródło: Proktologia 2002: 3 (2) s.143-147, il., bibliogr. 16 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Wstęp: W naszej instytucji nabyliśmy wiele doświadczeń w dziedzinie proktologii. Siedem lat temu wprowadziliśmy do naszej praktyki "chirurgię jednego dnia" i uzyskaliśmy bardzo dobre wyniki leczenia praktycznie u wszystkich pacjentów wymagających chirurgicznego leczenia chorób proktologicznych. Materiał, metoda i wyniki: W tym okresie do leczenia chirurgicznego zakwalifikowano 6126 spośród 41913 pacjentów leczonych ambulatoryjnie . W grupie tej było 23,1 proc. pacjentów operowanych z powodu krwiaka okołoodbytowego. Uzyskaliśmy też pewne doświadczenia w zakresie drobnych zabiegów w okolicy odbytu (usunięcie wyrośli skórnych u 17,0 proc. pacjentów, wycięcie brodawek u 5,3 proc. pacjentów); pacjenci z chorobą hemoroidalną, operowani klasyczną metodą Milligana-Morgana (10,46 proc.) albo nową metodą PPH wg Longo (1,9 proc.). Leczono też 11,7 proc. pacjentów z przetoką okołoodbytniczą, stosując fistulotomię lub wycięcie przetoki, oraz 10,9 proc. pacjentów z drobnymi problemami chirurgicznymi (operacje włókniaków, torbieli naskórzastych, brodawek, ganglionów, tłuszczaków itp.). Usunęliśmy polipy odbytu i odbytnicy u 7,6 proc. pacjentów, torbiele przywłośne u 6,1 proc., leczyliśmy także 1,3 proc. pacjentów z ropniem odbytu. Wykonaliśmy beznapięciową plastykę przepukliny pachwinowej u 4,5 proc. pacjentów., a także korekcji stomii u 0,14 proc. pacjentów. Wnioski: W naszym doświadczeniu operacje w warunkach "chirurgii jednego dnia" stanowią właściwy sposób leczenia wielu ...

Streszczenie angielskie: Introduction: In our institution we've had a lot of experience in proctology. Seven years ago we introduced one day surgery in our practice and had really good results in treating practically all patients who needed proctologic surgery. Material, methods and results: During this period of time 6,126 out of 41,913 outpatient cases were chosen for surgery. Among them, 23.1 p.c. were patients with operations of perinal haematomas. We had some experiences with minor anal surgery (excisions of skin tags in 17.0 p.c. patients, excisions of papillas in 5.3 p.c. patients); patients with haemorrhoids, operated classically on Milligan-Morgan procedure (10.46 p.c.) or by the new PPH - Longo procedure (1.9 p.c.). We also treated 11.7 p.c. patients with fistulas - either with fistulotomy or excision of fistulae - and 10.9 p.c. patients with minor surgery (operations of fibromas, verrucas, ganglions, lipomas, etc.). We made excisions of anorectal polyps in 7.6 p.c. patients, excisions of pilonidal cysts in 6.1 p.c. patients and treated 1.3 p.c. patients with anal abscesses. We made tension free operations of groin hernias in 4.5 p.c. patients and corrections of stomas in 0.14 p.c. patients. Conclusions: We have experienced ambulatory surgery (i.e. day surgery hospital) as an appropriate choice for treating the patients with proctologic pathology. However, it used to be the practice to treat all these patients in hospitals, where they occupied occupied bed facilities that could be ...

246/2523

Tytuł oryginału: New modalities in the treatment of haemorrhoids.
Tytuł polski: Nowe metody leczenia choroby hemoroidalnej.
Autorzy: Bielecki Krzysztof
Źródło: Proktologia 2002: 3 (2) s.149-151, 153-154, tab., bibliogr. 15 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: W pracy omówiono leczenie choroby hemoroidalnej ze szczególnym uwzględnieniem nowych metod. Przedstawiono technikę i wyniki leczenia. Dokładnie omówiono wskazania i wyniki po stosowaniu staplerowej hemoroidektomii w odmianach Longo i Stram. Najbardziej rekomendowaną przez autora jest Doppler-duided haemorrhoidal artery ligation, która wydaje się być najmniej bolesną techniką leczenia.

Streszczenie angielskie: In this paper various treatment options of haemorrhoidal disease are discussed, with special emphasis on new methods. Particular techniques and treatment results are presented. Indications and results of stapled haemorrhoidectomy by the Longo and the STRAM methods are discussed in detail. The author recomends the Doppler-guided haemorrhoidal artery ligation, which appears as the least traumatic and painful treatment technique.

247/2523

Tytuł oryginału: Indications and possibilities of semi-invasive treatment of hemorrhoids.
Tytuł polski: Wskazania i możliwości półinwazyjnego leczenia choroby hemoroidalnej.
Autorzy: Skricka Tomas, Vedra Pavel
Źródło: Proktologia 2002: 3 (2) s.155, 157-161, il., bibliogr. 17 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Prawie 70 proc. osób dorosłych po 30. roku życia cierpi z powodu hemoroidów, mając objawy takie, jak krwawienie, ból i miejscowy odczyn zapalny. W tradycyjnym ujęciu nasilenie choroby określa się wg 4-stopniowej skali, zależnie od zakresu wypadania żylaków odbytu. W pierwszym etapie stosuje się leczenie farmakologiczne, ukierunkowane na zwalczanie krwawienia, bólu i podrażnienia, a także likwidację stanu zapalnego. Zaleca się miejscowe stosowanie środków antyseptycznych i antybiotyków, aby uniknąć miejscowego zakażenia. Metody półinwazyjne obejmują skleroterapię, krioterapię, fotokoagulację i podwiązanie gumowymi taśmami. W przypadku niewielkich hemoroidów, powodujących głównie krwawienie bez wypadania śluzówki, leczeniem z wyboru jest skleroterapia. Obecnie praktycznie zaprzestano wykonywania zabiegów krioterapii z uwagi na dużą bolesność i krwawienie. W przypadku hemoroidów pierwszego stopnia godną polecenia metodą jest fotokoagulacja. Zakładanie podwiązek gumowych pozwala uzyskać wyniki równie dobre jak przy zastosowaniu metod tradycyjnych, jednak zaletą podwiązek jest możliwość stosowania ich w warunkach ambulatoryjnych bez znieczulenia miejscowego. Metoda uważana jest za najlepszy i najbezpieczniejszy półinwazyjny sposób leczenia hemoroidów, nie tylko w przypadku choroby w drugim stopniu zaawansowania. Kombinacja diety, dbałości o prawidłowe wypróżnienia, farmakoterapię i leczeniapółinwazyjnego pozwala uzyskać dobre wyniki u ponad 90 proc. pacjentów.

Streszczenie angielskie: Almost 70 p.c. of adult population over 30 suffer from haemorrhoids with symptoms of bledding, pain and inflammation. Traditional grading divides into four degrees depending on the extent of prolaps. First choice of treatment is drug therapy, which has to include therapy of bleeding, pain and irritation as well as anti-inflammatory. The use of antiseptics and antibiotics should be used by preference to guard against local infection. Semi-invasive therapy includes sclerotherapy, cryotherapy, fotocoagulation and rubber-band ligation. The sclerotherapy is the first line of treatment in minor degree heamorrhoids particularly those causing bleeding without mucosal prolapse. Cryotherapy is practically abandoned on the ground of pain and profuse discharge. Photocoagulation is good and sufficient method of treatment in the first-degree haemorrhoids. Rubberband ligation enables to achieve results as valid as those of traditional methods in the treatment of haemorrhoids with the advantage of employing it in out-patient development with no need for local anasthesia. It is considered to be the best and most safe semi-invasive method of treatment not only of the second-degree haemorrhoids. Combination of diet, improvement of emptying, pharmacotherapy and semi-invasive treatment can treat more that 90 p.c. patients successfully.

248/2523

Tytuł oryginału: Rectal cancer - functional outcome and quality of life.
Tytuł polski: Rak odbytnicy - czynnościowe wyniki leczenia i jakość życia.
Autorzy: Szczepkowski Marek
Źródło: Proktologia 2002: 3 (2) s.162-174, tab., bibliogr. 25 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

onkologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Celem pracy było przedstawienie jakości życia pacjentów po operacjach z powodu raka odbytnicy. Przedstawiono analizę porównawczą pacjentów po brzuszno-kroczowej amputacji odbytnicy i chorych po przedniej niskiej resekcji z zachowaniem zwieraczy. W ocenie jakości życia chorych brano pod uwagę następujące elementy: a) funkcjonowanie organizmu i ogólny stan zdrowia (physical functioning); b) stan psychologiczny (psychologic functioning); c) sfera socjalna (praca zawodowa, relacje z osobami bliskimi - rodzina, znajomi, model wypoczynku i rozrywki) (social functioning); d) życie intymne (sexual functioning). W obu grupach pacjentów, zarówno po brzuszno-kroczowym odjęciu odbytnicy, jak i po przedniej niskiej resekcji odbytnicy, występuje znaczące obniżenie jakości ich życia. Pomimo że ogólny stan zdrowia pacjentów w obu grupach w większości przypadków jest dobry (u ponad 60 proc.), nieregularne wypróżnienia i biegunka występują często. Pacjenci ze stomią częściej zgłaszają problemy związane z niekontrolowanym oddawaniem gazów i problemy urologiczne, z kolei chorzy z zachowanymi zwieraczami skarżą się na zaparcia. Pacjenci ze stomią znacznie częściej skarżą się na depresję, poczucie osamotnienia, a nawet rozpaczy z powodu złej samooceny i poczucia niekorzystnej zmiany wyglądu własnego ciała. Poczucie to występuje zwłaszcza u młodych pacjentów, częściej u kobiet. Rak jelita grubego wywołuje zaburzenia socjalne, takie jak niechęć do podjęcia aktywności zawodowej po operacji, ...

Streszczenie angielskie: The aim of this paper is to present the quality of life of patients operated on for rectal cancer. A comparative analysis of patients after abdominoperineal resection vs. patients after low anterior resection with preservation of sphincters is presented. When assessing the quality of life of patients, the following issues were considered; a) function of the whole organism and general condition (physical functioning); b) psychological well-being (psychological functioning); c) professional activity, relations with relatives and friends, leisure activities (social functioning); d) intimate relations (sexual functioning). In both groups of patients, both after abdominoperineal resection and after low anterior resection, a significant deterioration in the quality of life was noted. In spite of a good general health condition in the majority of cases (over 60 p.c. in both groups), frequent are irregular stools and diarrhoea. Stoma patients complain about uncontrolled passing of gas and urologic problems, while patients with preserved sphincter complain about constipation. Stoma patients significantly more often suffer depression loneliness and even despair due to low self-esteem and feeling of unfavourable change in body appearance. This feeling is present more often in younger patients and in women. Rectal cancer may cause social dysfunction, like reluctance to resume professional activity after surgery, limitation of socialcontacts, change of model of rest and leisure ...

249/2523

Tytuł oryginału: Current treatment of metastatic colorectal cancer.
Tytuł polski: Aktualne sposoby leczenia nawrotów raka jelita grubego.
Autorzy: Carrato Alfredo
Źródło: Proktologia 2002: 3 (2) s.175-178, tab., bibliogr. 17 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Uważa się, że u ok. 50 proc. pacjentów ze świeżo rozpoznanym rakiem jelita grubego (CRC) dojdzie do powstania przerzutów, a 5-letnia przeżywalność wynosi 50 - 60 proc. Dla poprawy przeżywalności pacjentów z zaawansowanym rakiem jelita grubego konieczne jest wdrożenie paliatywnej chemioterapii i leczenia skojarzonego. Dawniej podstawą leczenia CRC w fazie przerzutów był 5-fluorouracyl (5-FU), najpierw w monoterapii, a następnie w połączeniu z innymi cytostatykami wg odpowiednich schematów. Ostatnio zastosowano połączenie 5-FU z bardziej aktywnymi nowymi preparatami. Jednym z nich jest irinotekan (inhibitor topoizomerazy), który może indukować odpowiedź terapeutyczną nawet w przypadkach odpornych na 5-FU. Oksaliplatyna (związek platyny) w połączeniu z 5-FU wydłuża czas przeżycia bez progresji, jednak bez istotnego wydłużenia mediany całkowitego czasu przeżycia. Analiza genetyczna, mająca na celu określenie molekularnych czynników rokowniczych, powinna pomóc w zdefiniowaniu grup pacjentów, którzy najbardziej skorzystaliby z określonej metody leczenia. W osiągnięciu tego celu może pomóc zindywidualizowana chemioterapia, prowadzona w oparciu o indywidualne cechy konkretnego pacjenta. Połączenie chemioterapii i immunoterapii, zastosowanie inhibitorów metaloproteinaz, czynników blokujących angiogenezę, czynników blokujących transdukcję sygnałów i terapia genowa pozostają na razie we wczesnej fazie badań, ale stanowią logiczne kierunki dalszego rozwoju metod leczenia.

Streszczenie angielskie: 50 p.c. of newly diagnosed patients with colorectal cancer progress to metastatic disease with a 5-year survival of 50 - 60 p.c. There is need palliative chemotherapy in advanced CRS as well as adjuvant treatment to improve survival. In the past 5-fluorouracil has been the mainstream in metastatic CRC, initially as a monotherapy and then in conjunction with other agents in regimens. More recently 5-FU have been combined with active newer agents. One of them is irinotecan (topoisomerase inhibitor) which is capable of inducing response in-patients resistant to 5-FU. Oxaliplatin (platinum compound) in combination with 5-FU improved progression free survival without a significant increase in median survival time. Genetic analyses to help identify molecular prognostic factors should define more precisely which group of patients will benefit from a specific therapy. Customized chemotherapy based on each patient's individual features can help to attain thil goal. Combinations of chemotherapy with immunotherapy, metalloprotease inhibitors treatment, antiangiogenic agents, signal transduction inhibitors and gene therapy are early trials and are logical steps for future clinical development.

250/2523

Tytuł oryginału: Therapeutic approach of anal cancer.
Tytuł polski: Metody leczenia raka odbytu.
Autorzy: Karaitianos I. G., Maraghoudakis E. N.
Źródło: Proktologia 2002: 3 (2) s.179-182, tab., bibliogr. 20 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Rak odbytu występuje rzadko. Nazwa ta odnosi się do najczęstszego nowotworu złośliwego okolicy odbytu - raka kolczystokomórkowego. Jest to jedyny nowotwór złośliwy przewodu pokarmowego, gdzie możliwe jest wyleczenie bez radykalnej operacji. Rak odbytu jest w większości przypadków chorobą miejscową, przerzuty odległe w chwili rozpoznania stwierdza się u mniej niż 10 proc. pacjentów. Nowotwory odbytu klasyfikuje się tak jak nowotwory skóry, w oparciu o system TNM. W leczeniu dąży się do miejscowego i regionalnego opanowania nowotworu, w miarę możliwości przy zachowaniu funkcji zwieraczy. Dostępne metody leczenia obejmują: leczenie chirurgiczne, radioterapię i skojarzoną radio- i chemioterapię. Resekcja brzuszno-kroczowa, będąca postępowaniem z wyboru w przypadku raków zlokalizowanych poniżej linii grzebieniastej, w coraz większym stopniu jest zastępowana przez radioterapię, dającą taką samą przeżywalność. Radioterapia jako monoterapia daje 5-letnią przeżywalność u powyżej 70 proc. Jeszcze korzystniejsze jest połączenie radio- i chemioterapii. Schematy leczenia obejmują podanie 5-fluorouracylu z mitomycyną albo z cisplatyną. Miejscowe wycięcie niewielkich nowotworów z 1-cm marginesem, nawet z objęciem części aparatu zwieraczowego, pozwala uzyskać 5-letnią przeżywalność u powyżej 80 proc. Resekcja brzuszno-kroczowa jest stosowana w przypadku braku skuteczności chemioterapii i w przypadku wznowy miejscowej.

Streszczenie angielskie: Carcinoma of an anus is an uncommon disease, which refers to the commonest anal malignancy - squamous cell carcinoma. It remains the only carcinoma of GI tract curable without the need for definitive surgery. Anal cancer is predominantly a locoregional disease with fewer than 10 p.c. of patients having distant metastases at presentation. Tumors of anal margin are classified with skin tumors which is based on TNM stating. Treatment objectives include local and regional control over the tumor and maintenance of sphincter function when possible. The methods of treatment include surgery, radiotherapy and combined radio-chemotherapy. Abdominoperineal resection as a treatment of cancers located below dentate line is as a first intention treatment has been mostly replaced by radiotherapy with the same survival rate. Radiation treatment alone may lead to a 5-year survival rate in excess of 70 p.c. Combination of radio- and chemotherapy is even more beneficial. Treatment protocols involve administration of 5-fluorouracil with mitomycin or even better with cisplatine. Local excision of small carcinomas demonstrates over 80 p.c. 5-year survival rate obtained with 1 cm clear margin which may include part of sphincter apparatus. Abdominoperineal resection is reserved as salvage therapy fort he failure of prior chemotherapy and in local recurrences.

251/2523

Tytuł oryginału: Surgical achievements in Crohn's disease.
Tytuł polski: Wyniki leczenia chirurgicznego choroby Crohna.
Autorzy: Delaini G. G., Marinello P., Nifosi F., Carrara B.
Źródło: Proktologia 2002: 3 (2) s.183-184, bibliogr. 6 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Postęp w dziedzinie chirurgicznego leczenia choroby Crohna dotyczy głównie rozwoju technik umożliwiających oszczędzenie jelita, zmniejszenie urazu operacyjnego i zachowanie zwieracza odbytu. Plastyka miejsca zwężenia (strikturoplastyka) wskazana jest w przypadku zmian miejscowych, zwężeń mnogich na długich odcinkach jelita, u pacjentów po przebytych resekcjach, w przypadku nawrotu zwężenia w miejscu zespolenia krętniczo-okrężniczego oraz w przypadku zwężenia dwunastnicy. Strikturoplastyka pozwala uniknąć mnogich, rozległych resekcji i późniejszego wystąpienia "zespołu krótkiego jelita". Stosowane techniki obejmują metody Heineckego-Mikulicza, Finneya oraz izoperystaltyczną strikturoplastykę bok-do-boku. U niektórych pacjentów z chorobą Crohna możliwe jest wykonanie zespolenia zbiornika krętniczego z odbytem. Zabiegi laparoskopowe szybko zyskują popularność w chirurgicznym leczeniu choroby Crohna, a ich zalety to dobry wynik kosmetyczny, szybki powrót do zdrowia, krótki czas hospitalizacji, rzadkie występowanie powikłań i mniejsze ogólne koszty leczenia. Mniejszy jest też uraz operacyjny i mniejsze ryzyko powstania zrostów.

Streszczenie angielskie: New surgical achievements are especially related to bowel-sparing techniques, to reduction of surgical trauma and preservation of anal sphincter. Stricturoplasty is indicated in skin lesions, multiple strictures sited in long segments, in-patients with previous resection, recurrence of ileocolic anastomotic strictures, strictures of the duodenum. Stricturoplasty avaids multiple, broad resections and possible short bowel syndrome. Techniques employed include Heinecke-Mikulicz, Finney or side-to side isoperistaltic stricturoplasty. Ileal pouch anal anastomosis is feasible in selected patients with Crohn's disease. Laparoscopic procedures are diffusing rapidly in surgery for Crohn's disease, with good cosmetic results, faster recovery, shorter hospital stay, fewer complications and lower costs. Trauma is reduced and possibility to create adhesions is also reduced.

252/2523

Tytuł oryginału: Anal fistula.
Tytuł polski: Przetoka okołoodbytnicza.
Autorzy: Rosa G., Lolli P., Vicenzi L., Bottura D., Castellini C.
Źródło: Proktologia 2002: 3 (2) s.185-187, tab., bibliogr. 8 poz., streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

ludzie

Streszczenie polskie: Chirurgiczne leczenie przetok odbytu oparte jest na identyfikacji głównego kanału przetoki i jej wtórnych odgałęzień. Konfigurację przetoki można określić poprzez znalezienie jej ujść - zewnętrznego i wewnętrznego - oraz przebiegu samego kanału. Absolutnie przeciwwskazane jest nacinanie zwieracza odbytu, jeśli nie została jednoznacznie określona konfiguracja przetoki. Autorzy przeprowadzili 751 operacji przetoki odbytu. Wśród nich było 64 proc. przypadków wysokiego odejścia odgałęzień wtórnych, co znacznie utrudniało leczenie. U 85 proc. pacjentów kanał przetoki przechodził przez zwieracze. Najczęściej wykonywanym zabiegiem była fistulotomia i fistulektomia, jeśli przetoka nie obejmowała aparatu zwieraczowego. Przecięcie zwieracza było odraczane poprzez założenie setonu u 51 proc. spośród 436 przypadków przetok przezwieraczowych. Autorzy nie stosują techniki przesunięcia płata. Przed zabiegiem u wszystkich pacjentów przeprowadza się badania manometryczne w celu określenia zakresu nacięcia zwieracza. Po zabiegu odsetek nawrotów wynosił 4,2 p.c., a nietrzymanie stolca występowało u 0.98 proc. pacjentów.

Streszczenie angielskie: Surgical approach to anal fistulas has to be based on identification of main track and secondary extension. Track features come from identification of primary and secondary fistula opening and traject. It absolutely forbidden to cut sphincter when clear tract identification is lacking. Authors performed 751 fistula operations. Among them 64 p.c. had secondary high tracks, which makres the treatment more difficult. 85 p.c. patients had a fistula passingthough sphincters. The most performed operation was fistulatomy and fistulectomy if the fistula did not involve the sphincters. The sphincter cutting was delayed with seton in 51 p.c. of 436 transsphincteric fistulas. Authors do not practice advancement flap techniques. All patient are evaluated manometrically before the procedure to determine the extend of sphincter cut. Reported recurrence rate was 4.2 p.c. and incontinence in 0.98 p.c. of patients.

253/2523

Tytuł oryginału: Anual fissure - pathophysiology and management.
Tytuł polski: Szczelina odbytu - patofizjologia i postępowanie.
Autorzy: Pfeifer Johann
Źródło: Proktologia 2002: 3 (2) s.188-189, streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

praca kliniczna

Wskaźnik treści:

ludzie

Streszczenie polskie: Etiologia szczeliny odbytu pozostaje nieznana, jednak za najbardziej prawdopodobne przyjmuje się skojarzone działanie urazu, niedokrwienia i wady anatomicznej. W ostatnich dziesięcioleciach standardowym postępowaniem stała się sfinkterotomia boczne, z odsetkiem powikłań nie przekraczającym 5 proc. Leczenie zachowawcze polega na miejscowym stosowaniu toksyny botulinowej, blokerów kanału wapniowego i substancji uwalniających tlenek azotu. Zasada leczenia zachowawczego jest taka sama jak w przypadku leczenia chirurgicznego - zmniejszenie napięcia, ciśnienia i bólu w obrębie odbytu celem przyspieszenia gojenia. Sfinkterotomia chemiczna z zastosowaniem tlenku azotu stanowi korzystną alternatywę obarczoną niewielkim ryzykiem efektów niepożądanych i może być uznana za metodę z wyboru w leczeniu pacjentów ze szczeliną odbytu.

Streszczenie angielskie: Etiology of anal fissure is not known, however trauma with ischemia in combination with the anatomical structure is the most likely one. In the last decader standard therapy is lateral sphineterotomy with less than 5 p.c. of complication rates. Conservative management involves botulinum toxin, calcium channel blocker or NO-donor substances topical application. The idea behind the conservative treatment is identical to radical approach - to diminish anal pressure and pain in odrer to speed up the healing. Chemical sphincterotomywith NO is a viable option with small side effects and can be considered the procedure of choice for patients with anal fissures.

254/2523

Tytuł oryginału: Surgery for incontinence. Role of artificial sphincter.
Tytuł polski: Chirurgiczne leczenie nietrzymania stolca. Zastosowanie sztucznego zwieracza odbytu.
Autorzy: Pfeifer Johann
Źródło: Proktologia 2002: 3 (2) s.190-191, streszcz., rez.
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

praca przeglądowa

Wskaźnik treści:

ludzie

Streszczenie polskie: Uważa się, że ok. 1,5 proc. osób w populacji ogólnej cierpi z powodu nietrzymania stolca, a brudzenie bielizny występuje u ok. 5 proc. U pacjentów z nasilonym i nieodwracalnym nietrzymaniem stolca możliwości leczenia chirurgicznego są ograniczone. Poza operacjami polegającymi na przemieszczeniu mięśni duże nadzieje wiąże się z implantacjami sztucznego zwieracza (artifical bowel sphincter, ABS). Jest to urządzenie zbudowane z mocnego elastomeru silikonowego, wypełnione płynem i składające się z mankietu, pompy i balonu regulującego ciśnienie. Odsetek powikłań jest niewielki, a głównym problemem są zakażenia. Chirurgiczne leczenie nietrzymania stolca musi być zindywidualizowane i dostosowane do konkretnej sytuacji klinicznej. Duże nadzieje budzi zastosowanie systemu ABS, pod warunkiem, że uda się uniknąć zakażeń.

Streszczenie angielskie: It is said that up to 1.5 p.c. of population suffer from fecal incontinence, with soiling rate up to 5 p.c. For patients with severe irreparable fecal incontinence the surgical options are limited. Besides muscle transfer operations implantation of artificial bowel sphincter is a promising technique. It consist of fluid-filled, solid silicone elastomer device built of: cuff, pump and pressure regulating ballon. The complication rates seem to be very low with predominant factor of infection. Surgical treatment of fecal incontinence must be tailored to individual patient although ABS system is a promising device if infection can be avoided.

255/2523

Tytuł oryginału: 7th Central Congress of Coloproctology and Viscerosynthesis Italian - Baltic Week, June 2-4, 2002, Kaunas, Lithuania. Abstracts, [programme].
Źródło: Proktologia 2002: 3 (2) s.192-223, tab. - 7 Środkowoeuropejski Kongres Koloproktologii i Wiscerosyntezy - tydzień włosko - bałtycki Kaunas 02-04.06. 2002
Sygnatura GBL: 313,572

Hasła klasyfikacyjne GBL:

gastroenterologia

Typ dokumentu:

streszczenie

256/2523

Tytuł oryginału: Implication of immunological abnormalities after adenotonsillotomy.
Autorzy: Zielnik-Jurkiewicz Beata, Jurkiewicz Dariusz
Źródło: Int. J. Pediatr. Otorhinolaryngol. 2002: 64 (2) s.127-132, tab., bibliogr. 20 poz.
Sygnatura GBL: 306,189

Hasła klasyfikacyjne GBL:

otorynolaryngologia

Typ dokumentu:

praca opublikowana za granicą

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The adenoids and tonsils are thought to be essential parts of the system protecting organism against pathogens invading the upper respiratory tracts. Human adenoids and tonsils are known to be immunologically reactive lymphoid organs, which manifest specific antibodies and B and T cells activity in response to variety of antigens carrying out the functions of humoral and cellular immunity. The purpose of the study was to observe the changes in systemic immunity in children with hypertrophy of adenoids and tonsils treated in Department of Laryngology, Children's Hospital in Warsaw in period 1994-1999. The study comprised 80 patients (33 girls and 47 boys, aged from 3 to 14 years, mean age 6.8 years) with diagnosed hypertropphy of adenoids and tonsils. The diagnosis of hypertrophy of adenoids and tonsils was based on characteristic history and laryngological examination. All patients were scheduled for adenotonsillotomy. The control group comprised 40 people (14 girls and 26 boys, aged from 3 to 15 years, mean age 7.6 years) without hstory of the recurrent upper tract infections. In all patients we carried out following examinations: serum levels of immunoglobulins A, G, M (humoral immunity); percentage of T lymphocytes (CD3); percentage of T helper (CD4) and T cytotoxic (CD8) lymphocytes (cellular immunity) and delayed cutaneous hypersensitivity - Multitest CMI (cell mediated immunity). Our study demonstrate that in children with hypertrophy of adenoids and tonsils exist changes in the immunological parameters...

257/2523

Tytuł oryginału: Raccoon dog (Nyctereutes procyonoides) - the new host of Echinococcus multilocularis in Poland.
Autorzy: Machnicka-Rowińska Barbara, Rocki Bogusław, Dziemian Ewa, Kołodziej-Sobocińska Marta
Źródło: Wiad. Parazytol. 2002: 48 (1) s.65-68, tab., bibliogr. [14] poz.
Sygnatura GBL: 303,658

Hasła klasyfikacyjne GBL:

mikrobiologia

Typ dokumentu: