Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: TYTUŁ OBCOJĘZYCZNY
Liczba odnalezionych rekordów: 2523



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1/2523
- Gdańsk, , Via Medica 2002
Tytuł angielski: Images in psychiatry Poland
Opracowanie edytorskie: Bilikiewicz Adam (red.), Rybakowski Janusz (red.).
Źródło: - Gdańsk, Via Medica 2002, 212 s. : il., tab., bibliogr. [przy rozdz.], 24 cm.
Sygnatura GBL: 744,580

Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca historyczna
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XIX wieku
  • historia XX wieku
  • ludzie


    2/2523

    Tytuł oryginału: Are there any disturbances in vestibular organ of children and young adults with type I diabetes?
    Autorzy: Gawron W., Pośpiech L., Orendorz-Frączkowska K., Noczyńska A.
    Źródło: Diabetologia 2002: 45 (5) s.728-734, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 312,048

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Aims/hypothesis. The aim of the work was to evaluate the vestibular organ condition in children and young adults suffering from Type I (insulin-dependent) diabetes mellitus. Methods. The group examined consisted of 95 children and young adults aged from 6 to 28 years with Type I diabetes diagnosed. The diabetic group was divided into subgroups according to duration of the disease, compensation of the disease, and presence and character of hypoglycaemic incidents, and presence of diabetic complications. The control group consisted of 44 healthy children and young adults aged 6 to 28 years. After collecting detailed medical history in each case an electronystagmographic test was performed using the computed two-canal electronystagmographer. Results. Within the diabetic group 6 patients complained about vertigo and balance disorders. Spontaneous nystagmus occurred in 10 cases, positional one in 21 cases. Impaired optokinesis occurred in 36 cases and impaired eye tracking test in 33 cases. In caloric tests there was partial canal paresis in 4 cases and directional preponderance in 7 cases. Conclusion/interpretation. Metabolic disturbances present in Type I diabetes cause disturbances in different parts of vestibular organ but mostly in its central part. Comparing disturbances in the vestibular organ with clinical and biochemical parameters characterising diabetes, the range of vestibular organ impairment in diabetes mellitus type 1 seems to depend mainly on the presence and character of hypoglycaemic incidents and the duration of the disease and to some extent on the compensation of diabetes.


    3/2523

    Tytuł oryginału: Antiaggregatory activity of hypoglycaemic sulphonylureas.
    Autorzy: Siluk D., Kaliszan R., Haber P., Petrusewicz J., Brzozowski Z., Sut G.
    Źródło: Diabetologia 2002: 45 (7) s.1034-1037, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 312,048

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • in vitro

    Streszczenie angielskie: Aims/hypothesis. Vascular complications observed in diabetes are often related to altered platelet functions. The most widely used hypoglycaemic drugs for treating Type II (non-insulin-dependent) diabetes mellitus are sulphonylurea derivatives. The purposes of this study were to evaluate the inhibitory effects of hypoglycaemic agents on platelet aggregation, to measure their lipophilicity and identify their structural parameters which assess their antiaggregatory activity. Methods. An antiaggregatory test in vitro was carried out for 13 sulphonylurea derivatives. Aggregation of platelets, incubated with the agents at concentrations varying from 7.5 to 480 ćmol/l, was induced by 10 ćmol/l ADP. Drug lipophilicity parameter, log kw, was measured by gradient HPLC and the agents were subjected to molecular modelling. Results. The most pronounced inhibition of platelet aggregation was by glimepiride, gliclazide, gliquidone, glibenclamide and compound 2A. The IC25 values were 15.9, 18.6, 20.4, 28.5 and 34.7 ćmol/l, respectively. Quantitative structure-activity relationships indicate that antiaggregatory activity is mainly affected by electronic and not by lipophilic properties of the agents. Conclusion/interpretation. Glimepiride appeared to be a more potent ADP-induced platelet aggregation inhibitor in vitro than gliclazide. Antiaggregatory activity was shown for gliquidone and confirmed for glibenclamide. The QSAR analysis supports the hypothesis of a free radical mechanism of action of sulphonylurea derivatives previously suggested for gliclazide.


    4/2523

    Tytuł oryginału: History and present situation of Paediatric ENT Surgery in Poland and in other Central East European countries.
    Autorzy: Chmielik Mieczysław, Bielicka Anna, Ranocha Cezary, Chmielik Lechosław
    Źródło: New Med. 2002: 5 (2) s.46-48, tab., bibliogr. 5 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: One of the first paediatric ENT centres in the world was the research group managed by Jan Danielewicz in Warsaw. It was organised on the basis of progress clinics and paediatric ENT wards, and a programme of specialisation was established (1, 2). Almost simultaneously, in the sixties of the twentieth century, centres for paediatric ENT were established in Prague, Berne, Bratislava, Budapest, Bucharest and Sophia. In the nineteen-seventies these were in touch with the centre for paediatric ENT in Italy, which was the pioneer in this speciality in West Europe. The effect of this contact was the creation of the European Federation of Oto-Rhino-Laryngology Societies, and the International Federation of Oto-Rhino-Laryngological Societies (IFOS), and further dynamic progress in this specialisation.


    5/2523

    Tytuł oryginału: Tracheotomy in children - indications and complications.
    Autorzy: Zawadzka-Głos Lidia, Chmielik Mieczysław
    Źródło: New Med. 2002: 5 (2) s.49-52, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Tracheostomy is a life-saving procedure when pertbrmecl with an appropriate indication and surgical technique. There is a limited indication for tracheostomy procedures in paediatrie surgery. It is rarely applied to the paediatric patient because they can be kept intuhated for a longer period compared to adults. Indications for tracheostomy are prolonged intubation, subglotie stenosis, general body trauma, tracheomalasia, cervical tumour pressing the trachea and larynx, congenital diseases of the larynx, burn injuries of the trachea, and foreign body aspiration. In the last decade the number of cases with tracheotomy increased due to the development of new intensive care units, the use of mechanical ventilation, and the increasing number of patients needing prolonged ventilation support. Tracheotomy in children lias been associated with significant operative and post-operative complications. When long-term tracheotomy is needed, parent education, together with special equipment and environment may allow the return of the tracheotomised child to home in secure conditions.


    6/2523

    Tytuł oryginału: Nasal and sinus diseases in children - surgical treatment.
    Autorzy: Chmielik Mieczysław, Brożek Eliza
    Źródło: New Med. 2002: 5 (2) s.53-54, bibliogr. 10 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Plastic surgery of the lateral nasal wall in children has been performed in Warsaw Paediatric ENT Clinic since 1995. There have been 121 operations. They consisted of conservative reconstruction of congenital or acquired defects in this area. In most eases a decrease in the number of upper airways infections and permanent improvement of nasal patency was attained. None of the cases lias shown any inhibitory influence from these procedures on craniofacial development. The principles of accomplishing conservative plastic surgery of the nasal mucous membrane are defined.


    7/2523

    Tytuł oryginału: Laryngeal haemangioma in children.
    Autorzy: Chmielik Mieczysław, Zając Beata
    Źródło: New Med. 2002: 5 (2) s.55-57, bibliogr. 22 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Haemangiomas and vascular malformations located in the larynx are rare hut potentially life-threatening conditions, because they compromise the airway. The authors present the clinical symptoms and method of diagnostic evaluation of these lesions. Various techniques for the treatment oflaryngeal haemangioma are discussed, but no single approach has universal acceptance.


    8/2523

    Tytuł oryginału: Assessment of hearing in children in postoperative treatment of choanal atresia.
    Autorzy: Zawadzka-Głos Lidia, Bielicka Anna, Chmielik Mieczysław
    Źródło: New Med. 2002: 5 (2) s.58-60, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Choanal atresia is a congenital abnormality often coexisting with other developmental abnormalities. The treatment of choice his condition is surgical restoration of choanae patency using a transnasal or transpalatal operative approach. After ;ical treatment, separators are fixed for several weeks in the posterior choanae and nasopharynx. Surgical transpalatal rvention and extended retention of separators in the posterior choanae and nasopharynx may cause auditive tube unction and otitis media with effusion. The aim of this work was the estimation of the occurence of otitis media with sion in children under post-operative treatment after choanal atresia depending on the surgical approach applied. immary of the period 1959-2002 in the Department of Paediatric Otorhinolaryngology in Warsaw shows that 175 operations s performed because of choanal atresia. A group of 11 children operated on choanal atresia between 1996-2002 was nined. Acoustic impedance audiometry was performed in all children. Bilateral choanal atresia was recognised in 4 children, unilateral choanal atresia in 7 children. A tympanomctry curve type B was obtained in 4 children, but a tympanometry curve type A was found in 7. In the examined group we did not find a dependence between the type of operative approach in surgical treatment of choanal atresia and otitis media with effusion occurrence.


    9/2523

    Tytuł oryginału: Tonsil operations in children - indications and contradictions.
    Autorzy: Chmielik Mieczysław, Bielicka Anna, Brożek Eliza
    Źródło: New Med. 2002: 5 (2) s.61-63, bibliogr. 10 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Adenoidectomy, tonsillectomy and tonsillotomy were and still are the most common surgical procedures performed in Paediatric Otorhinolaryngology. The aim of this study is to justify the use of these methods in particular cases, and also specifying the complications that might occur in the postoperative period. The indications for the procedures are divided into definite and relative, while the complications are separated into two groups, early and late. The information given in the text is based on the experience of the Paediatric ENT Clinic of the Medical University of Warsaw, and the available literature.


    10/2523

    Tytuł oryginału: Laryngeal papillomatosis in children and their surgical treatment.
    Autorzy: Zawadzka-Głos Lidia, Chmielik Mieczysław, Bielicka Anna
    Źródło: New Med. 2002: 5 (2) s.64-66, bibliogr. 17 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Laryngeal papillomas in children constitute a disease of viral aetiology caused by Human Papilloma Virus. Even though the changes arc histologically benign, their exophytic growth may lead to a critical airway obstruction and the child's suffocation. Due to the tendency to recur, lack of causal treatment, and risk of malignancy the optimal method of treating this condition is still being sought. The study presents methods applied nowadays in the treatment of laryngeal papillomas; especially, it concentrates on a classical papillotomy and its main advantage: the diminished risk of scar formation leading to laryngeal stenosis and vocal fold injury with speech disorders.


    11/2523

    Tytuł oryginału: Vertigo and dizziness in children - diagnostic problems.
    Autorzy: Chmielik Jolanta, Chmielik Mieczysław, Zając Beata, Gabryszewska Anna, Szapłyko Waldemar
    Źródło: New Med. 2002: 5 (2) s.67-70, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The purpose of the study was to review clinical presentation, diagnostic methods, and conditions causing vertigo and dizziness in children. The authors report a retrospective review of 70 children diagnosed in the ENT Department or Outpatient Clinic in the Department of Paediatric Neurology. The differential diagnosis of dizziness and vertigo in children requires a multidisciplinary approach. Close co-operation between the otolaryngologist, paediatrician, neurologist and ophtalmologist allows the best chance of accurate diagnosis. From an analysis of the results, a diagnostic approach to the dizzy child is suggested, and the most frequent conditions causing vertigo in children are discussed.


    12/2523

    Tytuł oryginału: Ventilating tube insertion in the treatment of otitis media with effusion in children.
    Autorzy: Dębska Małgorzata, Bielicka Anna, Chmielik Mieczysław
    Źródło: New Med. 2002: 5 (2) s.71-72, bibliogr. 17 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The authors present methods of surgical treatment of otitis media with effusion in children. The advantages and complications of ventilating tube insertion are given particullar attention.


    13/2523

    Tytuł oryginału: Clinical aspects of ethmoiditis.
    Autorzy: Chmielik Mieczysław, Gabryszewska Anna
    Źródło: New Med. 2002: 5 (2) s.73-75, bibliogr. 12 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Ethmoiditis is a condition which any GP may meet in his practice. In this paper we describe the pathomechanisms which lea( to acute and prolonged sinusitis in children, the diagnostics, and prognosis. Particular attention is paid to complications which may be tragic in children. We also consider possible treatments and management when complications occur.


    14/2523

    Tytuł oryginału: Frontometaphyseal dysplasia in a 3 5/12 year-old girl and in the "unaffected mother".
    Autorzy: Marik Ivo, Kozlowski K.
    Źródło: New Med. 2002: 5 (2) s.76-79, il., bibliogr. 15 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • płeć żeńska

    Streszczenie angielskie: We report a girl with fromtometaphyseal dysplasia in whom the first phenotypic abnormality noted at the age of 3 months was metopic suture torus. At the end of the first year of life knock knee deformity and torsion of the legs was noted and this progressed in spite of orthotic treatment. The diagnosis of frontometaphyseal dysplasia was established at the age of 3 years 5 months. Family studies revealed that the mother, supposed to be normal was also affected. Previously unreported clinical manifestations and radiographic findings are documented to further delineate and expand the spectrum of the disorder.


    15/2523

    Tytuł oryginału: A new, distinctive from of spondylo-epi-metaphyseal dysplasia.
    Autorzy: Beighton P., Kozlowski K.
    Źródło: New Med. 2002: 5 (2) s.80-82, il., bibliogr. 5 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • płeć męska

    Streszczenie angielskie: Spondylo-epi-metaphyseal dysplasias are a group of complex disorders, most of which defy classification. We report a patient with distinctive radiographic features who presents a previously undescribed form of spondylo-epi-metaphyseal dysplasia.


    16/2523

    Tytuł oryginału: Hallucinations, illusions, and other visual disturbances in neurology.
    Autorzy: Brzecki Andrzej, Kobel-Buys Krystyna, Buys Guido
    Źródło: New Med. 2002: 5 (2) s.83-88, il., bibliogr. 57 poz.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The authors describe the visual pathway and especially the posterior part of the optic visual radiation and visual representation in the cuncus of the occipital cortex. Almost the entire visual tract is supplied by the posterior cerebral artery, except for central vision representation, which is supplied by a branch of the middle cerebral artery. Therefore, damage to the visual pathway of one hemisphere may cause hetcronymous hemianopsia or quadrantanopsia and, less frequently, visual hallucinations and illusions. Hallucinations and illusions may also occur - exempli gratia - in infectious encephalopathies, poisonings, sleep disorders and psychoses. In particular, stimulation of the temporal lobe by toxins or drugs having dopamincrgic, semtoninergic or adrenergic actions (frequently true or ,,false" neurotransmitters) may also cause them. Examples of paintings done by artist under the influence of some hallucinogens has been presented. Prosopgnosia and prosopagnosia have been discussed. Prosopagnosia may be caused by an injury the right hemisphere. Anosognosia of the left part of the body and the left visual field have to been also discussed. A case study of a patient with visual hallucinations and illusions of his own enormous extremities in the course of thrombosis of the posterior cerebral artery has been mentioned. Also, in connection with this theme, we discussed anosognosia of the left part of the body and left visual field spatial neglect, cortical blindness etc. and we mentioned border zone infarcts as a new problem of vascular diseases in elderly patients. ...


    17/2523

    Tytuł oryginału: Analihz pihdgotovki sihmejjnikh lihkarihv v dejakikh krajinakh svihtu ta problemi vprovadzhennja sihmejjnoji medicini v Ukrajinih.
    Tytuł angielski: Comparative characteristic of family medicine in some countries and the possibility of introduction them in Ukraine.
    Autorzy: Chopejj Ih. V.
    Źródło: New Med. 2002: 5 (1) s.3-9, bibliogr. 11 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the paper presented the various models of family medicine. There are done the conclusion about the adequate model for Ukraine in the transitive economic period.


    18/2523

    Tytuł oryginału: Dosvihd nadannja pervinnoji mediko-sanihtarnoji dopomogi khvorim na khronihchnih obstruktivnih zakhvorjuvannja legen, jajkih poterpihli vnasljidok ekologihchnoji katastrofi - povenih.
    Tytuł angielski: Experience of the primary medical and sanitary help render to patients with chronic obstructive pulmonary diseases, who were suffering from ecological disaster - flood.
    Autorzy: Rogach Ih. M., Lemko Ih. S., Melega-Zajac K. P., Melega O. O., Lemko O. Ih., Brich V. D., Ljakh V. V., Kihrejj K. Ja, Gabor M. L., Kazankevich V. P.
    Źródło: New Med. 2002: 5 (1) s.10-12, bibliogr. 6 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • pulmonologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: The peculiarities of chronic obstructive pulmonary diseases in patients who were suffering from flood were studied in dependence influence's nature of the ecological disaster factors. The ways and means of medical and sanitary help efficiency's increase were shown in account of nosology, disease's severity, nature of flood factors influence, period, which has passed after flood.


    19/2523

    Tytuł oryginału: Kontrol za efektivnihstju trivaloji antigihpertenzivnoji terapihji enalaprilom v praktichnihjj robotih sihmejjnogo lihkarja.
    Tytuł angielski: Checking the effcacy of prolonged antihypertention therapy with enalapril in practical woru of a family doctor.
    Autorzy: Nejjko Je. M., Orinchak M. A., Seredjuk N. M., Gorban Je. M., Vakaljuk Ih. P., Aleksandruk D. P., Jacishin R. Ih., Vihrstjuk N. G., Seredjuk V. N., Glushko N. L., Artemenko N. R., Lihbrik O. Ja., Cherkashina O. Je.
    Źródło: New Med. 2002: 5 (1) s.13-15, bibliogr. 6 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: 137 patients in the middle and older age with arterial hypertension (AH) of the P and Sh stage were observed. The speading of AH in different regions of Precarpathia in dependance from climatical - geografical and socioeconomical conditions was studied. It was stated that the indexes of the daily monitoring of blood preassure are informational prognostical criterial of AH running and also are the criteria of the effectivness of the antihypertensive therapy. The effectiveness of the long time use of the angiotensin-converting enzyme inhibitor of enalapri in different age groups of the patients was proved. The study of psychological condition of the patient with the help to the questioneer may serve as the criteria of valuing the effectiveness of healing and social rehabilitation of the AH patients. The recommendation for the family doctors concerning healing and the prevention of the complicates of the AH on the base of the researth results were worked out.


    20/2523

    Tytuł oryginału: Suchasnih programi monihtoringu zakhvorjuvan' organihv travlennja u prakticih lihkarja sihmejjnoji medicini.
    Tytuł angielski: The modern programs of the monitoring of alimentary tract's diseases in outpatient's practice of a general practitioner.
    Autorzy: Chernobrovijj V. M., Melashhenko S. G., Palihjj Ih. G., Pihvtorak N. A., Zajika S. V., Skripka A. A., Fedzhaga Ih. V., Kavka S. O., Kosenko S. V., Fostakovs'kijj D. S., Chernova Ih. V., Morozova O. Ih., Burka N. V., Kolihsnik S. P.
    Źródło: New Med. 2002: 5 (1) s.16-20, bibliogr. 9 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The article is devoted to the experience of treatment widespread alimentary tract's diseases in outpatient's practice by using methods of control gastrointestinal disorders: acid-related (hyperacidity, hypoacidity, gastroesofageal and duodenogastral reflux) and nonacid-related (contamination of microogranisms, vertebrogenic).


    21/2523

    Tytuł oryginału: Rol' sihmejjnoji medicini v optimihzacihij roboti po profihlakticih gostrikh porushen' mozkovogo krovoobihgu.
    Tytuł angielski: The role of family medicine in optimization of prevention of acute cerebral circulatory disturbans.
    Autorzy: Pulik O. R., Chopejj I. V., Pulik R. O.
    Źródło: New Med. 2002: 5 (1) s.21-23, bibliogr. 9 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In the article the various models of optimization of prevention of acute cerebral circulatory disturbances are presented. The significant role of the "patient's diary" has been shown.


    22/2523

    Tytuł oryginału: Ocihnka antigihpertenzivnoji dihji betaksolola (lokrenu) v gostrikh farmakodinamihchnikh testakh u khvorikh na arterihal'nu gihpertenzihju, shho perenesli ihnfarkt mihokarda (za danimi dobovogo monihtoruvannja arterihal'nogo tisku).
    Tytuł angielski: The studing of arterial blood pressure monitoring results under the influence of lokren revealed its significant antihypertensive efficacy both after the first 20 mg dose and after 2-weeks course of treatment.
    Autorzy: Vakaljuk I. P., Stasjuk L. B., Zvonar P. P., Lihbrik O. M.
    Źródło: New Med. 2002: 5 (1) s.24-27, il., bibliogr. 8 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The estimation of antihypertensive efficacy of lokren during the pharmonodynamic tests in patients with arterial hypertension, after acute myocardial infraction (by data of arterial blood pressure monitoring). While treating patients with 20 mg of Lokren the decreasing of systolic and diastolic arterial blood pressure variability and heart rate was observed.


    23/2523

    Tytuł oryginału: Analihz vrodzhenikh vad rozvitku plodu v oblasnomu centrih Zakarpattja ta jikh znachennja v prakticih sihmejjnogo lihkarja.
    Tytuł angielski: Some data of ultrasonic investigation of pregnant women and analysis of natal defects of fetus during the time period of 1993-1999 in the town of uzhgorod.
    Autorzy: Chopejj O. Ih., Slivka N. V., Chopejj K. Ih.
    Źródło: New Med. 2002: 5 (1) s.28-31, tab., bibliogr. 5 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • pediatria
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki

    Streszczenie angielskie: We studied the data of prenatal ultrasound diagnostics of abnormalities in fetus. Coincidence of prenatal and postnatal diagnoses was registered in 92 p.c. Structure and index of rate of abnormalities in fetus were compared with the data of monitoring in newborns. The differences have been analyzed.


    24/2523

    Tytuł oryginału: Optimihzacihja navchal'nogo procesu lihkarihv zagal'noji praktiki na ciklih "kardihologihja" shljakhom vikoristannja suchasnikh ihnformacihjjnikh tekhnologihjj.
    Autorzy: Glushko L. V., Fedorov S. V., Makovec'ka T. Ih., Ostrovs'kijj M. M., Berezovs'ka L. A.
    Źródło: New Med. 2002: 5 (1) s.32-33, bibliogr. 3 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The demands made to quality of training physicians to be are defined in the programs and directives of the Ministry of Public Health and Education of Ukraine. One of the factors directed to profound medical subjects studying is subsequent optimizing the training process, namely raising use of information technologies in teaching. This article gives facts and figures concerning forming postgraduate medical training of general practicioners in cardiology cycle using the modern information technologies.


    25/2523

    Tytuł oryginału: Rezultati vivchennja pokaznikihv pH slizovoji obolonki tovstoji kishki ta vikoristannja v klihnihchnihjj prakticih jikh zmihni pihd vplivom lihkuvannja.
    Tytuł angielski: PH-metry in the patients having irritable bowel syndrome and variable pH after treatment.
    Autorzy: Rusin Ih. S., Ihl'ko A. V., Ploskihna V. Ju., Kanchihjj V. M., Rihshko V. V.
    Źródło: New Med. 2002: 5 (1) s.34-35, tab., bibliogr. 4 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The methods and the results of transcolonoscopic pH-metria of the different parts of bowels, changes of this indices attached to diseases of this part of the gastrointestinal tract under influence of different complexes of treatment are being discussed in this publication.


    26/2523

    Tytuł oryginału: Docihl'nihst' vikoristannja al'ternativnikh metodihv lihkuvannja khvorikh kardihologihchnogo profihlju v prakticih sihmejjnogo lihkarja.
    Tytuł angielski: The expediency of alternative treatment methods used in a family doctor's practice.
    Autorzy: Shkoda-Ul'janova N. V., Dolgosh M. Ju., Panas S. V.
    Źródło: New Med. 2002: 5 (1) s.36-39, il., tab., bibliogr. 9 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Taking into consideration a significant number of the adverse effects, which appear after the treatment of the cardio - vascular diseases, namely: 1) tolerance; 2) cancellation syndrome; 3) paradoxical effect; it is suggested, as an alternative, to use angio - injeel, which could be applied both independently, as a monotherapy, and with other traditional remedies. The dosage, in this case, is decreased, contributing to the less number of cases of the aversive effects.


    27/2523

    Tytuł oryginału: Vivchennja ta mozhlivostih lihkuvannja gelihkobakterihozy v rodinakh khvorikh z urazhennjam gastrodyodenal'noji zoni.
    Tytuł angielski: Study and opportunity of helicobacteriosis treatment in families of the patients with gastroduodenal disorders.
    Autorzy: Kolesnik P. O., Chopejj Ih. V., Rubcova Je. Ih., Dolgosh M. Ju., Drozd S. Ih., Knishev V. Ih., Kharitonova Z. B., Kuz'mik V. M.
    Źródło: New Med. 2002: 5 (1) s.40-44, bibliogr. 12 poz., sum.
    Sygnatura GBL: 313,682

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The main theme of the article contains analysis of intrafamiliar clustering and transmission which is implicated as a major route for acquisition of Helicobacter pylori infection. The occurrence of digestive disorders in household members of the patients with chronic gastritis and duodenal ulcer disease families was observed by clinical and instrumental investigation. It proves the high risk of digestive disorders, associated with Helicobacter pylori, in the household members of the index patients. The results of the analysis prove the necessity of all-family eradication treatment in order to avoid reinfection, intrafamiliar clustering and transmission of Helicobacter pylori infection. It can also reduce the risk of digestive disorders, associated with Helicobacter pylori, in the household members of the index patients. The household members and the index patients treatment by the schedule list (which included omeprasole, augmentine, cyprofloxacine during 7 days) caused high eradication effect observed by invasive tests and was mostly alwaysaccompanied by changes in Ig G titres.


    28/2523
    2002
    Tytuł polski: Probabilistic causal models in medicine: application to diagnosis of liver disorders : praca doktorska
    Autorzy: Oniśko Agnieszka, Bobrowski Leon (promot.).; [Akademia Medyczna w Białymstoku]
    Źródło: 2002, [1], X, 140 k. : il., tab., bibliogr. 158 poz., sum., maszyn.
    Sygnatura GBL: 45/23902

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doktorska
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    29/2523

    Tytuł oryginału: Medical humanities in Central and Eastern Europe : the example of Poland
    Autorzy: Szawarski Zbigniew
    Źródło: W: Integration of medical humanities into the education of health care professionals - Vilnius, 2002 s.17-23 - Włączenie humanistyki medycznej do kształcenia personelu służby zdrowia Wilno 28-29.06. 2002 - Oddzielna numeracja stron tekstu litewskiego w odwrotnym kierunkuTytuł odwróconej odkładki także w jęz. litewskim
    Sygnatura GBL: 555,550

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    30/2523

    Tytuł oryginału: Assessment of long-term effects of exposure to toluene based on the analysis of selected behavioral responses with particular reference to the ability to trigger behavioral hypersensitivity in rats.
    Autorzy: Wiaderna Dorota, Tomas Tadeusz
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.239-245, il., bibliogr. 20 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Toluene is a major component of numerous commercial organic solvent formulations. It is often listed among the chemicals capable of producing the organic solvent syndrome and a neurobehavioral hypersensitivity condition. The hypersensitivity condition (continued long-term intensification of some behavioral reactions in response to pharmacological or environmental stressor) is usually associated with the increased tonus of the functional dopaminergic system. The aim of our current research was to determine whether, under conditions of inhalation exposure, toluene can produce long-term behavioral changes or modify the intensity of the behavioral response to apomorphine, a dopaminergic receptor agonist. In our experiment, male rats were exposed to 25, 100 and 250 ppm toluene for 4 weeks (5 days/week, 6h/day). The following behaviors were tested: finding water in a radial maze; open field motor activity; acquiring the conditional response of passive avoidance; sensitivity to a thermal pain stimulus (hot plate test) and changes in this sensitivity caused by stress; and acquiring the conditional response of two-directional active avoidance. The behavioral response to apomorphine, i.e. the increased spontaneous locomotor activity, was assessed on day 10 after the termination of the exposure in the rotary drum test. In the behavioral experiment, significant differences between groups were recorded only for hot plate test; in the 100 and 250 ppm rats, electric-shock-related anxiety response was stronger than in the control group. In the experiment using pharmacological provocation...


    31/2523

    Tytuł oryginału: Effects of occupational exposure to a mixture of solvents on the inner ear: a field study.
    Autorzy: Sułkowski Wiesław J., Kowalska Sylwia, Matyja Wojciech, Guzek Wojciech, Wesołowski Wiktor, Szymczak Wiesław, Kostrzewski Przemysław
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.247-256, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Some clinical and laboratory studies that industrial solvents such as toluene, styrene, xylene, trichloroethylene and carbon disulfide or their mixtures may affect the inner ear, although the mechanism of this process is still not well understood. The aim of this investigation was to assess the incidence of hearing and vestibular disorders (using modern audiological and vestibular tests) in 61 workers exposed to a mixture solvents at the production of paints and varnishes; the control group included 40 age-matched non-exposed subjects. Environmental and biological monitoring revealed that the most significant exposure can be attributed to the following mixture constituents: ethylbenzene, xylene and trimethylbenzene isomers such as pseudocumene, mesitylene and hemimellitene. Electronystagmographic examinations showed the symptoms of vestibular dysfunction, as well as the decreased duration, amplitude and slow phase angular velocity of induced nystagmus in 47.5 p.c. of the subjects exposed versus 5 p.c. of controls. This was accompanied by sensorineural high frequency hearing loss, identified by means of pure tone audiometry in 42 p.c. of those exposed versus 5 p.v. controls, and reduced amplitudes of transiently evoked and distoration-product otoacoustic emissions. The findings closely correspond with the rate total exposure to the solvent mixture. A possible mechanism responsible for ototoxicity of solvents is discussed.


    32/2523

    Tytuł oryginału: Hospitalizations among teachers in Denmark, 1981-1997.
    Autorzy: Hannerz Harald, Albertsen Karen, Tchsen Finn
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.257-266, il., tab., bibliogr. 61 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: ll systems and organs of the body were statistically significant lower among teachers compared with other economically active people of Denmark.

    Streszczenie angielskie: It is a common notion that teachers constitute a group at high risk of occupational stress, but the potential health consequences of the assumed high stress levels are still poorly illuminated. The aim of the present study was to investigate morbidity among Danish teachers. Cohorts of Danish teachers of primary, secondary and vocational schools, aged 20-59 years in 1981, 1986, 1991 and 1994, were formed to calculate age standardized hospitalization ratios (SHRs) and time trends (1981-1997) for a large variety of diagnostic aggregations. Statistically significantly low SHRs for the major disease categories: neoplasms, diseases of the nervous, circulatory, respiratory, digestive and musculoskeletal systems were found both for man and women. We also found significantly low SHRs for the aggregated diagnostic group "injury and poisoning" in men and for diseases of the nervous and sense organs in women. Age standardized hospitalization rates with respect to diseases observed in practically all systems and organs of the body were statistically significantly lower among teachers compared with other economically active people of Denmark.


    33/2523

    Tytuł oryginału: Mortality study of workers compensated for asbestosis in Poland, 1970-1997.
    Autorzy: Szeszenia-Dąbrowska Neonila, Wilczyńska Urszula, Szymczak Wiesław, Strzelecka Alicja
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.267-278, tab., bibliogr. 21 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to assess the risk of asbestos-related malignancies among persons with diagnosed asbestosis. The study covered a cohort composed of 907 men and 490 women afficted by asbestosis, diagnosed in 1970-1997. The follow-up of the cohort continued until 31 December 1999. In all, 421 deaths were registered and causes of death were retrieved for 93.3 p.c. of the deceased. A significantly increased mortality was observed both in the male (300 deaths; SMR = 127; 95 p.c. CI: 113-142) and female (121 deaths, SMR = 150; 95 p.c. CI: 124-179) cohorts. The elevated number of deaths in the male and female cohorts were noted mainly due to respiratory diseases (men: 42 deaths; SMR = 344; 95 p.c. CI: 248-465 women: 20 deaths, SMR = 789; 95 p.c. CI: 482-1219) malignant neoplasms (men: 91 deaths, SMR = 146; 95 p.c. CI: 118-179; women: 34 deaths, SMR = 159; 95 p.c. CI: 110-222), including lung cancer (men: 39 deaths, SMR = 168; 95 p.c. CI: 119-230; women: 13 deaths, SMR = 621; 95 p.c. CI: 331-1062) and pleural mesothelioma (men: 3 deaths, SMR = 2680; 95 p.c. CI: 553-7832; women: 3 deaths, SMR - 7207; 95 p.c. CI: 1031-14612). Taking into account a cumulative dose of fibres, it was found that a significantly increased mortality from lung cancer and pleural mesothelioma applied to persons exposed to a dose above 25 f-y/ml. The results indicate that persons with asbestosis are at higher risk of developing malignant neoplasms, especially lung cancer and mesothelioma.


    34/2523

    Tytuł oryginału: Lung function and surface electromyography of intercostal muscles in cement mill workers.
    Autorzy: Meo Sultan A., Azeem Muhammad A., Ghori Moinuddin G., Subhan Mirza M. F.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.279-287, tab., bibliogr. 48 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia
  • toksykologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Impairment of pulmonary function in cement mill workers has been previously reported without considering a variety of parameters that can help evaluate more thoroughly the effect of cement dust on the respiratory system. In addition, an integrated approach has not been considered to assert the involvement of respiratory muscles. Therefore, in the present study spirometry and surface electromyography (SEMG) of intercostal muscles were used for indicating pulmonary impairment. In this study, a group of 50, apparently healthy volunteers, male cement mill workers aged 20-60 years with exposure of 13 years on average, were randomly selected. They were matched with another group of 50 control healthy male subjects in terms of age, height, weight and socioeconomic status. Both groups met the standard exclusion criteria. Spirometry was performed on an electronic spirometer, while SEMG of intercostal muscles was performed by using a chart recorder. The results demonstrated statistically significant reduction in lung function parameters i.e., force vital capacity (FVC) (p 0.0005); force expiratory volume in first second (FEV1) (p 0.0005); peak expiratory flow (PEF) (p 0.005); and maximum voluntary ventilation (MVV) (p 0.0005) in cement mill workers, when compared with controls. However, the FEV1/FVC ratio was significantly higher (p 0.025) in cement mill workers. Similarly, the parameters obtained from SEMG of intercostal muscles, i.e. number of peaks (NPO) (p 0.0005); maximum peak amplitude (MPA) (p 0.0005); peak to peak amplitude (PPA) (p 0.0005)...


    35/2523

    Tytuł oryginału: Occupational exposure to organic dust associated with municipal waste collection and management.
    Autorzy: Krajewski Jan A., Tarkowski Stanisław, Cyprowski Marcin, Szarapińska-Kwaszewska Jadwiga, Dudkiewicz Bożena
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.289-301, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • mikrobiologia
  • toksykologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to assess the occupational exposure of workers employed in the municipal waste collection and management industry. Air samples were collected in the workers' breathing zone; two samples were collected parallely. The assessment concerned exposure to organic dust, endotoxins, bacteria and fungi. The questionnaire data showed that workers found themselves in good or very good health. They also regarded noise, dustiness, odor, physical effort and changeable atmospheric conditions as the most strenuous factors. The highest dust concentrations were observed on the sites of waste collection (mean, 7.7 mg/m3) and composting (mean, 4.6 mg/m3). Samples collected on the composting site contained the largest amount of endotoxins (mean concentration, 76 ng/m3). This was followed by sorting facility (61 ng/m3) and waste collection area (36 ng/m3). Gram-negative rods (primarily intestinal) were found in all samples collected at workposts, which justified the adoption of the air concentrations of endotoxins as a criterion for assessing their hygienic conditions. Taking MAC for total suspended dust (4.0 mg/m3) and the concentration of 10 ng/m3 for endotoxin as the criteria for the exposure evaluation, it must be considered that waste collectors and composting site workers are working in poor hygienic conditions. Workers employed at the most hazardous workposts did not use personal protective equipment (glasses, antirespirators), thus infringing a fundamental condition for limiting health hazards (Directive 2000/54/EC).


    36/2523

    Tytuł oryginału: Remarks on safety assessment, quality assurance, and diagnostic reference levels in medical X-ray imaging.
    Autorzy: Golnik Natalia, Ratajczyk-Dziewięcka Małgorzata, Maciejewski Krzysztof
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.15-22, bibliogr. 10 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The new Polish legislation (Atomic Law) and recent recommendations of international organizations require to pay more attention to control the risk associated with the operation of medical radiation sources. A comprehensive regulatory framework is necessary to ensure that a consistent approach is applied to all elements of the safety system. The paper shortly describes how safety assessment fits into the regulatory process and provides some information on the elements of a safety assessment. Complementary to the safety assessment, a program of quality assurance, QA, should be implemented to periodically check all aparameters which influence the patient dose and the image quality. The last part of the paper concern the implementation of diagnostic reference levels, recommended as a practical tool to mange radiation dose to patients in diagnostic radiology and nuclear medicine.


    37/2523

    Tytuł oryginału: On the acoustic phenomena produced by turbulence in the flowing blood.
    Autorzy: Góral-Wójcicka A., Borgieł W., Małota Z., Nawrat Z.
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.29-35, il., bibliogr. 12 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: A turbulent flow can be a source of sounds called "murmur" or "souffle", and can be a result of pathology in the blood vascular system. A model of acoustical effects, related to stenosis of the aorta, was created. Numerical calculations of pressure fluctuations in the environment of a simulated turbulent region were performed.


    38/2523

    Tytuł oryginału: Dosimetric verification of dose distributions calculated for Co-60 beams with individual compensation filters.
    Autorzy: Perczak Aneta, Kukołowicz Paweł, Bulski Wojciech
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.49-61, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The compensating filters used in radiotherapy modify dose distribution in the entire field of the radiation beam, no matter what is the shape of the surface of the body. The determination of the shape of the compensator in a given clinical siluation calls for the use of advanced software tools. Modern treatment planning systems provide necessary modules needed to calculate the shapes of the compensation filters. Reliable use of these systems requires verification of such calculations. In this study, in order to evaluate the accuracy of the calculations, the dose distributions for Co-60 beams modified by the compensators, calculated by the computer system TMS-Helax were verified by comparing them with the measured dose distributions.


    39/2523

    Tytuł oryginału: The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteins.
    Autorzy: Noordzij Jeroen G., Bruin-Versteeg Sandra de, Verkaik Nicole S., Vossen Jaak M. J. J., Groot Ronald de, Bernatowska Ewa, Langerak Anton W., Gent Dik C. van, Dongen Jacques J. M. van
    Źródło: Blood 2002: 100 (6) s.2145-2152, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 301,770

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The protein products of the recombination activating genes (RAG1 and RAG2) initiate the formation of immunoglobulin (lg) and T-cell receptors, whichare essential for B- and t-cell development, respectively. Mutations in the RAG genes result in severe combined immunodeficiency disease (SCID), generally characterized by the absence of mature B and T lymphocytes, but presence of natural killer (NK) cells. Biochemically, mutations in the RAG genes result either in nonfunctional proteins or in proteins with partial recombination activity. The mutated RAG genes of 9 patients from 7 families were analyzed for their recombination activity using extrachromosomal recombination substrates, rearrangment of endogenous Ig loci in RAG gene-transfected nonlymphoid cells, or the presence of Ig gene rearrangements in bone marrow (BM). Recombination activity was virtually absent in all 6 patients with mutations in the RAG core domains, but partial activity was present in the other 3 RAG-deficient patients, 2 of them having Omenn syndrome with oligocional T lymphocytes. Using 4-color flow cytometry, we could define the exact stage at which B-cell differentiation was arrested in the BM of 5 RAG-deficient SCID patients. In 4 of 5 patients, the absence of recombination activity was associated with a complete B-cell differentiation arrest at the transition from cytoplasmic (Cy) Igć- pre -B-I cells to Cylgć+ pre -B-II cells. However, the fifth patient showed low frequencies of precursor B cells with Cylgć and surface membrane IgM...


    40/2523

    Tytuł oryginału: Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-B-ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease.
    Autorzy: Szczepański Tomasz, Willemse Marja J., Brinkhof Bas, Wering Elisabeth R. van, Burg Mirjam van der, Dongen Jacques J. M. van
    Źródło: Blood 2002: 99 (7) s.2315-2323, il., tab., bibliogr. 47 poz.
    Sygnatura GBL: 301,770

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements are excellent patient-specific polymerase chain reaction (PCR) targets for detection of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL), but they might be unstable during the disease course. Therefore, we performed detailed molecular studies in 96 childhood precusor-B-ALL at diagnosis and at relapse (n = 91) or at presumably secondary acute myeloid leukemia (n = 5). Clonal Ig and TCR tatgets for MRD detection were identified in 94 patients, with 71 p.c. of these targets being preserved at relapse. The best stability was found for IGK-Kde rearrangements (90 p.c.), followed by TCRG (75 p.c.), IGH (64 p.c.), and incomplete TCRD rearrangements (63 p.c.). Combined Southern blot and PCR data for IGH, IGK-Kde, and TCRD genes showed significant differences in stability at relapse between monoclonal and oligoclonal rearrangements: 89 p.c. versus 40 p.c., respectively. In 38 p.c. of patients all MRD-PCR targets were preserved at relapse, and in 40 p.c. most of the targets (ň 50 p.c.) were preserved. In 22 p.c. of patients most targets (10 cases) or all targets (10 cases) were lost at relapse. The latter 10 cases included 4 patients with secondary acute myeloid leukemia with germiline Ig/TCR genes. In 5 other patients additional analyses proved the clonal relationship between both disease stages. Finally, in 1 patient all Ig/TCR gene rearrangements were completely different between diagnosis and relapse, which is suggestive of secondary ALL...


    41/2523

    Tytuł oryginału: Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome.
    Autorzy: Juszyczyński Przemysław, Kalinka Ewa, Bienvenu Jacques, Woszczek Grzegorz, Borowiec Maciej, Robak Tadeusz, Kowalski Marek, Lech-Maranda Ewa, Baseggio Lucile, Coiffier Bertrand, Salles Gilles, Warzocha Krzysztof
    Źródło: Blood 2002: 100 (8) s.3037-3040, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 301,770

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: at least 2 inherited factors involved in NHL outcome.

    Streszczenie angielskie: Tumor necrosis factor (TNF) production and non-Hodgkin lymphoma (NHL) outcome was found to be related to the TNF-308 polymorphism. To explore whether this could be linked to neighboring polymorphisms, we genotyped the TNF-376,-308,-238,-163, lymphotoxin alpha (LTŕ)+252, and HLA DRB1 alleles in 204 patients with NHL and 120 controls. TNF-308A was the only allele associated with higher TNF and its p55 and p75 receptors' levels (P=.009, P=.03, and P=.007) and lower complete remission rates (P=.006). Freedom from progession (FFP) and overall survival (OS) were shorter in patients with TNF-308A (P=.009 and P=.02), null HLA DRB1*02 allele (P=.007 and P.14) or both genetic markers (P=.004 and P.005). Multivariate analysis incorporating international. Prognostic index (IPI) identified TNF-308A (P .0001, relative risk (RR) = 1.63; P .0001, RR=1.51) and null HLA DRB1*02 alleles (P=.015, RR - 1.18; P .0001, RR = 1.25) as independent factors for FFP and OS. These results indicate the existence of least 2 inherited factors involved in NHL outcome. (Blood. 2002; 100 : 3037-3040).


    42/2523

    Tytuł oryginału: Modulation of the activity of calcium-activated neutral proteases (calpains) in chronic lymphocytic leukemia (B-CLL) cells.
    Autorzy: Witkowski Jacek M., Żmuda-Trzebiatowska Emilia, Świercz Jakub M., Cichorek Mirosława, Ciepluch Hanna, Lewandowski Krzysztof, Bryl Ewa, Hellmann Andrzej
    Źródło: Blood 2002: 100 (5) s.1802-1809, il., bibliogr. 57 poz.
    Sygnatura GBL: 301,770

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Decreased susceptibility to apoptosis and impaired proliferative control are throught to be responsible for prolonged life spain and accumulation of chronic lymphocytic leukaemia (B-CLL) cells. The acitivity of calpains (calcium-dependent, neutral proteases, active in the cells responding to signals inducing a rise of cytoplasmic (Ca++) is involed in the regulation of apoptosis of some cell types by interaction with caspase-3. This work verifies the hypothesis of the abnormal activity of calpains and its role in reduced apoptosis of the BCL cells. Casein zymography, reverse transcriptase-polymerase chain reaction, and Western blotting were used for identification and quantification of the activity and expression of calpains (calcium-dependent, neutral proteases, active in the cells responding to signals inducing a rise of cytoplamic (Ca++) is involved in the regulation of apoptosis of some cell types by interaction with caspase-3. This work verifies the hypothesis of the abnormal activity of calpains and its role in reduced apoptosis of the B-CLL cells. Casein zymography, reverse transcriptase-polymerase chain reaction, and Western blotting were used for identification and quantification of the activity and expression of calpains in B-CLL cells and purified B lymphocytes. The activity and expression of ć-calpain (requiring micromolar Ca++ for activation) are significantly higher in the leukemic than in nonmalignant cells. Conctrarily, the activity and expression of m-calpain (requiring milimolar Ca++) as well as the expression of calpastatin (an endogenous inhibitor of...


    43/2523

    Tytuł oryginału: Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia.
    Autorzy: Hoelzer Dieter, G”kbuget Nicola, Digel Werner, Faak Thomas, Kneba Michael, Reutzel Regina, Romejko-Jarosińska Joanna, Zwoliński Jacek, Walewski Jan
    Źródło: Blood 2002: 99 (12) s.4379-4395, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 301,770

    Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We treated 45 adult patients with T-lymphoblastic lymphoma (T-LBL) (age range 15-61 years) with 2 protocols designed for adult acute lymphoblastic leukemia (ALL). An encouraging cure rate of 90 p.c. was recently reported for T-LBL in children treated with a similar approach. In our study an 8-drug standard induction was administered over 8 weeks including prophylactic cranial (24 Gy) and mediastinal irradiation(24 Gy) followed by consolidation and reinduction therapy. AT diagnosis, 91 p.c. of the 45 patients showed a mediastinal tumor and 40 p.c. had pleural/pericardial effusions: 73 p.c. of the patients had stage III/IV disease. Ovarall 42 patients (93 p.c.) achieved a complete remission (CR), 2 patients (4 p.c.) achieved a partial remission, and 1 patient (2 p.c.) died during induction. In patients with stage I-III disease (n=18) the CR rate was 100 p.c. compared with 89 p.c. in stage IV (n=27). There were 15 patients who relapsed (36 p.c.) within 12-months. The majority of relapses (47 p.c.) occurred in the mediastinum (n=7) despite mediastinal irradiation with 24 Gy in 6 out of 7 patients. The estimates for overall survival, continuous CR, and disease-free survival at 7 years are 51 p.c., 65 p.c., and 62 p.c., respectively. Stage, age, lactate dehydrogenase and all other parameters had no influence on achievement of CR or outcome. This study demonstrates in a large cohort of patients with adult T-LBL that a high CR rate and a favourable outcome can be achieved with an ALL-type regimen. Mediastinal recurrence was the major obstacle and further improvement...


    44/2523

    Tytuł oryginału: Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.
    Autorzy: Nieborowska-Skorska Małgorzata, Hoser Grażyna, Kossev Plamen, Wasik Mariusz A., Skorski Tomasz
    Źródło: Blood 2002: 99 (12) s.4531-4539, il., bibliogr. 68 poz.
    Sygnatura GBL: 301,770

    Hasła klasyfikacyjne GBL:
  • onkologia
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: BCR/ABL oncogenic tyrosine kinase activates STAT5, which plays an important role in leukemogenesis. The downstream effectors of the BCR/ABL- STAT5 pathway remain poorly defined. We show here that expression of the antiapoptic protein A1, a member of the Bcl-2 family, and the serine/threonine kinase pim-1 are enhanced by CRB/ABL. This up-regulation requires activation of STAT5 by the signaling from SH3 + SH2 domains of the BCR/ABL. Enhanced expression of A1 and pim-1 played a key role in the BCR/ABL-mediated cell protection from apoptosis. In addition, pim-1 promoted proliferation of the BCR/ABL-transformed cells. Both A1 and pim-1 were required to induce interleukin 3-independent cell growth, inhibit activation of caspase 3, and stimulate cell cycle progression. Moreover, simultaneous up-regulation of both A1 and pim-1 was essential for in vitro transformation and in vivo leukemogenesis mediated by BCR/ABL. These data indicate that induction of A1 and pim-1 expression may play a critical role in the BCR/ABL - depenendent transformation.


    45/2523

    Tytuł oryginału: Early detection of COPD by high-risk population spirometric screening.
    Autorzy: Zieliński J.
    Źródło: Eur. Respir. Rev. 2002: 12 (86/87) s.287-288
    Sygnatura GBL: 313,671

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    46/2523

    Tytuł oryginału: Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
    Autorzy: Johnson Richard J., Herrera-Acosta Jaime, Schreiner George F., Rodriguez-Iturbe Bernardo
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[23-33], il., bibliogr. 94 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    47/2523

    Tytuł oryginału: The vascular endothelin system is not overactive in normotensive hemodialysis patients
    Autorzy: Bssemaker Eckhart, Passauer Jens, Reimann Doreen, Schulze Beate, Reichel Wolfgang, Gross Peter
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[59-67], il., tab., bibliogr. 30 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    48/2523

    Tytuł oryginału: Ageing and heart failure : the place of ACE inhibitors in heart failure with preserved systolic function
    Autorzy: Tendera M[ichał]
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[69-75], il., tab., bibliogr. 54 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.


    49/2523

    Tytuł oryginału: Chronic hypokalaemia of adults : Gitelman's syndrome is frequent but classical Bartter's syndrome is rare
    Autorzy: Gladziwa U., Schwarz R., Gitter A. H., Bijman J., Seyberth H., Beck F., Ritz E, Gross P[eter]
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[81-87], il., tab., bibliogr. 22 poz., sum. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    50/2523

    Tytuł oryginału: Chronic, diagnosis-resistant hypokalaemia
    Autorzy: Reimann Doreen, Gross Peter
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[89-93], il., tab., bibliogr. 30 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    51/2523

    Tytuł oryginału: Oral antihyperglycemic therapy for type 2 diabetes
    Autorzy: Inzucchi Silvio E.
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[127-139], il., tab., bibliogr. 154 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    52/2523

    Tytuł oryginału: Insulin therapy in type 2 diabetes
    Autorzy: Hollander Priscilla
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[141-146], il., tab., bibliogr. 36 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    53/2523

    Tytuł oryginału: Advances in the treatment of renal anaemia
    Autorzy: Locatelli Francesco
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[147-160], il. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    54/2523

    Tytuł oryginału: HMG-CoA reductase inhibitors are associated with reduced mortality in ESRD patients
    Autorzy: Seliger Stephen L., Weiss Noel S., Gillen Daniel L., Kestenbaum Bryan, Ball Adrianne, Sherrard Donald J., Stehman-Breen Catherine O.
    Źródło: W: 2 Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[171-178], il., tab., bibliogr. 31 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    55/2523

    Tytuł oryginału: Atherogenic lipoproteins in end-stage renal disease
    Autorzy: Shoji Tetsuo, Ishimura Eiji, Inaba Masaaki, Tabata Tsutomu, Nishizawa Yoshiki
    Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[179-182], il., bibliogr. 23 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    56/2523

    Tytuł oryginału: Tailoring the initial vascular access for dialysis patients
    Autorzy: Konner Klaus, Hulbert-Shearon Tempie E., Roys Erik C., Port Friedrich K.
    Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[235-244], il., tab., bibliogr. 28 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska


    57/2523

    Tytuł oryginału: Peritonitis in peritoneal dialysis
    Autorzy: Voinescu C. G., Khanna R.
    Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[245-260], tab., bibliogr. 94 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    58/2523

    Tytuł oryginału: The malnutrition, inflammation, and atherosclerosis (MIA) syndrome : the heart of the matter
    Autorzy: Pecoits-Filho Roberto, Lindholm Bengt, Stenvinkel Peter
    Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[283-286], il., bibliogr. 34 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    59/2523

    Tytuł oryginału: Principles and practice of renal transplantation
    Autorzy: Kahan Barry D., Ponticelli Claudio
    Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[303-321], il., tab. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    60/2523

    Tytuł oryginału: Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis
    Autorzy: Dreke Tilman B.
    Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[337-339], bibliogr. 23 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
    Sygnatura GBL: 802,649

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    61/2523

    Tytuł oryginału: Influence of intensive movement rehabilitation in scout camps on ventilatory parameters of the respiratory tract in children with mild idiopathic scoliosis from highly polluted areas.
    Tytuł polski: Wpływ intensywnego usprawniania ruchowego podczas obozu harcerskiego na czynność układu oddechowego u dzieci ze skoliozą idiopatyczną, pochodzących ze środowiska skażonego.
    Autorzy: Żaba Ryszard
    Źródło: Wiad. Lek. 2002: 55 supl. 1 cz. 2: Konferencja naukowa "Śląskie dni medycyny społecznej i zdrowia publicznego" s.1003-1008, tab., bibliogr. 19 poz., streszcz. - Konferencja naukowa pt. Śląskie dni medycyny społecznej i zdrowia publicznego Zabrze - Szczyrk 2002
    Sygnatura GBL: 301,774

    Hasła klasyfikacyjne GBL:
  • pediatria
  • pulmonologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Przebadano grupę 42 dzieci ze skoliozą idiopatyczną I stopnia wg Cobba (skrzywienie kręgosłupa poniżej 30 stopni) oraz grupę kontrolną 14 zdrowych dzieci biorących uddział w harcerskim obozie zdrowotnym (Obóz I), jak również przebadano grupę 19 dzieci ze skoliozą I stopnia, która po raz drugi uczestniczyła w harcerskim obozie rehabilitacyjnym (Obóz II). U wszystkich badanych dzieci, zarówno przed jak i po pobycie na 4 tygodniowym obozie rehabilitacyjnym oznaczono aparatem Vitalograph następujące wskaźniki wentylacyjne płuc: pojemność życiową płuc - FVC, maksymalną objętość wydechową jednosekundową - FEV1 oraz określono FEV1 proc. FVC. Porównując średnie wartości mierzonych wskaźników spirometrycznych płuc przed i po pobycie na pierwszym Obozie Rehabilitacyjnym, nie wykazano statystycznie znamiennych przyrostów. Równocześnie porównując mierzone wskaźniki wentylacyjne FVC i FEV1 po pobycie na drugim Obozie Rehabilitacyjnym, wykazano statystycznie znamienne ich przyrosty.

    Streszczenie angielskie: In 42 children with mild idiopathic scoliosis Iř (spinal curvature less than 30ř) and in the control - 14 healthy children (camp I) as well as in 19 children with idiopathic scoliosis spending time in a camp for the second time (camp II) ventilatory lung parameters: vital capacity - VC, maximal forced expiratory volume one sec. - FEV1 and FEV1 p.c. FVC were determined. Tests were carried out with use of Vitalograph before and after four-week rehabilitation camp. When the mean values of spirometric parameters were compared between the two groups of children (camp I) before and after the camp, statistically significant values were not observed. Simultaneously, in children staying in the camp second time around (camp II), when the mean values of spirometric parameters were correlated between the two camps as well as before and after the second camp, statistically significant increased values of parameters were observed. Leaving Silesia, an area with high air pollution is one of the major tasks of Scout Health Camps for children with idiopathic scoliosis.


    62/2523

    Tytuł oryginału: Inhibition of alkaline phosphatase activity of boar semen by pentoxifylline, caffeine, and theophylline.
    Autorzy: Głogowski Jan, Danforth Douglas R., Ciereszko Andrzej
    Źródło: J. Androl. 2002: 23 (6) s.783-792, il., bibliogr. s. 790-792
    Sygnatura GBL: 313,131

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Methyl xanthines have been used frequently as additives to sperm suspensions in order to improve sper characteristics. The mechanism of action on spermatozoa is generally assumed to be inhibition of sperm phospodiesterase activity, resulting in elevation of complementary adenosine monophosphate levels in spermatozoa. The present study was designed to examine the effect of methyl xanthines (pentoxifylline, caffeine, and theophylline) on another important enzyme system, alkaline phosphatase, in boar seminal plasma and spermatozoa. Inhibition of sperm alkaline phosphatase could be distinguished from that of seminal plasma by a paradoxical stimulation by pentoxifylline at lower pH values in spermatozoa. Among the three methyl xanthines, theophylline exhibited the most dramatic inhibition of alkaline phosphatase activity and substrate inhibition was observed with increasing concentrations. Each methyl xanthine had a different action on alkaline phosphatase activity at lower pH; theophylline showed the highest inhibition, caffeine inhibition was not related to pH, and pentoxifylline did not inhibit alkaline phosphatase of seminal plasma and, in fact, it stimulated its activity (or that of a phosphatase with lower pH optimum) in spermatozoa. These results indicate another possible mechanism of action of methyl xanthines on sperm and are in agreement with data indicating that methyl xanthines are not specific inhibitors of sperm phosphodiesterase, because clearly, they inhibit alkaline phosphatase activity as well.


    63/2523

    Tytuł oryginału: Bacterial infections - an early detection and cellular defense.
    Tytuł polski: Zakażenia bakteryjne - wczesna diagnostyka i odporność komórkowa.
    Autorzy: Maliński Tadeusz
    Źródło: Nowiny Lek. 2002: 71 supl. 1: Zakażenia szpitalne: postępy w diagnostyce, terapii i profilaktyce s.19-20, bibliogr. 6 poz. - 9 Zjazd Polskiego Towarzystwa Zakażeń Szpitalnych pt. Zakażenia szpitalne: postępy w diagnostyce, terapii i profilaktyce Poznań 25-27.09. 2002
    Sygnatura GBL: 310,004

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    64/2523

    Tytuł oryginału: 8th European Congress of Dentomaxillofacial Radiology : programme and abstracts
    Źródło: - [Cracow, b.w. 2002], 96 s., 21 cm. - 8 Europejski Kongres Radiologii Stomatologicznej i Szczękowo-Twarzowej Kraków 06-08.06. 2002
    Sygnatura GBL: 735,461

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • radiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    65/2523

    Tytuł oryginału: Immunosupression in liver transplantation for hepatic and biliary malignancy : the effect on tumor recurrence
    Autorzy: Pączek Leszek, Ołdakowska-Jedynak Urszula
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[23-27] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia
  • transplantologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    66/2523

    Tytuł oryginału: Sixteen-year experience with liver transplantation in hepatocarcinoma, and comparison with liver resection
    Autorzy: Gonzalez-Pinto Ignacio
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[28-29] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • transplantologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.


    67/2523

    Tytuł oryginału: Indications and results of liver resection and transplantation for HCC
    Autorzy: Jonas Sven, Neuhaus Peter
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[30-33] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • transplantologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    68/2523

    Tytuł oryginału: Liver resection and transplantation for primary liver tumors
    Autorzy: Farges Olivier
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[33-34] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • transplantologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.


    69/2523

    Tytuł oryginału: Liver resection for HCC : IKEM prague experience
    Autorzy: Ryska M., Belina F., Langer D.
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[35] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 45-64 r.ż.


    70/2523

    Tytuł oryginału: Liver transplantation in children with hepatic tumors
    Autorzy: Kaliciński Piotr
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[36-37] - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia
  • transplantologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.


    71/2523

    Tytuł oryginału: Surgical treatment of the patients with HCC : experience of the Department of General and Liver Surgery
    Autorzy: Krawczyk Marek
    Źródło: W: Postępy w chirurgii i transplantacji wątroby : [program, wykłady i streszczenia] - [Warszawa, 2002] s.[38-44], il., tab. - 3 Międzynarodowe Sympozjum pt. Postępy w chirurgii i transplantacji wątroby Warszawa 22-23.11. 2002
    Sygnatura GBL: 735,774

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    72/2523

    Tytuł oryginału: DOTS Expansion Plan to Stop TB in the WHO European Region 2002-2006
    Opracowanie edytorskie: Danzon Marc (przedm.).
    Źródło: - [Cophenhagen, World Health Organization 2002], V, 46 s. : il., tab., 30 cm.
    Sygnatura GBL: 291,084

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • choroby zakaźne

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    73/2523

    Tytuł oryginału: Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer.
    Autorzy: Jereczek-Fossa Barbara A., Jassem Jacek, Badzio Andrzej
    Źródło: Int. J. Radiat. Oncol. Biol. Phys. 2002: 52 (2) s.476-482, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 312,578

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Purpose: To evaluate the relationship between acute and late normal tissue reaction in 317 consecutive endometrial cancer patients treated with surgery and adjuvant radiotherapy (RT). Methods: The data of 317 patients (staging according to the International Federation of Gynecology and Obstetrics) treated with postoperative RT were analyzed. Both low-dose-rat brachytherapy and external beam RT were applied in 247 patients (78 p.c.); brachytherapy only in 49 (15 p.c.) and external beam irradiation only in 21 (7 p.c.). The median follow-up was 7.3 years (range 4-21). The European Organization for Research and Treatment of Cancer, Radiation Therapy Oncology Group system with elements of the late effects of normal tissue, sibjective, objective, management, analytic (LENT/SOMA) scale was used to score the RT reactions. The correlation between the occurrence and severity of acute and late bowel and bladder toxicity, as well as the relationship between the severity of acute effects and time to occurrence of late reactions, were assessed using linear and logistic regression analyses. Results: Of the 317 patients, 268 (85 p.c.) experienced acute RT reactions of any grade. Severe acute bowel reactions were observed in 15 patients (5 p.c.), urinary bladder complications in 1 patient (0.5 p.c.) cutaneous in 1 patient (0.5 p.c.), and vaginal in 1 patient (0.5 p.c.). Severe acute hematologic toxicity was seen in 3 patients (1 p.c.). A total of 158 patients (51 p.c.) experienced late RT reactions of any grade. Severe late bowel reactions were obsrved in 19 patients (6 p.c.), urinary bladder in 5 (2 p.c.), vaginal in 3 (1 p.c.), and bone in 10 (4 p.c.)...


    74/2523

    Tytuł oryginału: Detection of enterotoxigenic Clostridium perfringens with a duplex PCR.
    Autorzy: Augustynowicz E[wa], Gzyl A., Ślusarczyk J.
    Źródło: J. Med. Microbiol. 2002: 51 (2) s.169-172, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 305,350

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Two sets of primers sedigned to detect Clostridium perfringens phospholipase C (plc) and enterotoxin (cpe) genes in a single PCR reaction were applied to a collection of 64 predominantly food poisoning-related C. perfringens isolates. In-vitro enterotoxin synthesis was tested serologically after inducing sporulation. Of the 64 isolates, 26 were clearly enterotoxigenic: 16 were classified as potentially enterotoxigenic only as serological testing did not confirm enterotoxin production, Duplex PCR for diagnosis of enteroxigenic C. perfringens from vegetative cultures can be a useful tool as fresh isolates often sporulate poorly or not all, giving rise to the possibility of false negative results by serological analysis.


    75/2523

    Tytuł oryginału: Free radicals-mediated induction of oxidized DNA bases and DNA-protein cross-links by nickel chloride.
    Autorzy: Woźniak Katarzyna, Błasiak Janusz
    Źródło: Mutat. Res 2002: 514 (1/2) s.233-243, il., tab., bibliogr. 50 poz.
    Sygnatura GBL: 304,952

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • in vitro

    Streszczenie angielskie: Using the comet assay, we showed that nickel chloride at 250-1000 ćM induced DNA damage in human lymphocytes, measured as the change in comet tail moment, which increased with concentration up to 500 ćM and then decreased. Observed increase might follow from the induction of strand breaks or/and alkali-labile sites (ALS) by nickel, whereas decrease from its induction of DNA-DNA and/or DNA-protein cross-links. Proteinase K caused an increase in the tail moment, suggesting that nickel chloride at 1000 ćM might cross-link DNA with nuclear proteins. Lymphocytes exposed to NiCl2 and treated with enzymes recognizing oxidized and alkylate bases: endonuclease III (Endo III), formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (AlkA), dusplayed greated extent of DNA damege than those not treated with these enzymes, indicating the induction of oxidized and alkylated bases by nickel. The incubation of lymphocytes with spin traps, 5,5-dimethyl-pyrroline N-oxide (DMPO) and PBN decreased the extent of DNA damage which might follow from the production of free radicals by nickel. The pre-treatment with Vitamin C at 10 ćM and Vitamin E at 25 ćM decreased the tail moment of the cells exposed to CiCl2 at the concentrations of the metal causing strand breaks or/and ALS. The results obtained suggest that free radicals may be involved in the formation of strand breaks or/and ALS in DNA as well as DNA-protein cross-links induced by NiCl2. Nickel chloride can also alkulate DNA bases. Our results support thesis on multiple, free radicals-based genotoxicity pathways of nickel.


    76/2523

    Tytuł oryginału: Comparative studies of osteoblast and fibroblast type I collagen in a patient with osteogenesis imperfecta type IV.
    Autorzy: Galicka Anna, Wołczyński Sławomir, Gińdzieński Andrzej
    Źródło: J. Pathol. 2002: 196 (2) s.235-237, il., bibliogr. 16 poz.
    Sygnatura GBL: 302,048

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The expression of type I collagen has been compared in fibroblast and osteoblast cultures of a patient with moderately severe osteogenesis imperfecta (OI) type IV, with respect to control cells. Electrophoretic analysis of type I collagen showed that both OI osteoblasts and fibroblasts synthesized normal chains with delayed migration. However, the osteoblasts contained a higher proportion of abnormal chains than fibroblasts from the proband. Pulse-chase experiments showed that the trimers containing abnormal chains were cleared more rapidly from osteoblasts than fibroblasts. Moreover, the collagen secreted by OI osteoblests had thermal stability 1řC higher than collagen secreted by OI fibroblasts. These results suggest that the abnormal collagen in osteoblasts may be more resistant to intra- and extracellular degradation and my thus have better survival than in fibroblasts. This finding could have implications for understanding the clinical phenotype of OI.


    77/2523

    Tytuł oryginału: Potentiating antitumor effects of a combination therapy with lovastatin and butyrate in the Lewis lung carcinoma model in mice.
    Autorzy: Giermasz Adam, Makowski Marcin, Kozłowska Ewa, Nowis Dominika, Maj Małgorzata, Jalili Ahmad, Feleszko Wojciech, Wójcik Cezary, Dąbrowska Anna, Jakóbisiak Marek, Gołąb Jakub
    Źródło: Int. J. Cancer 2002: 97 (6) s.746-750, il., bibliogr. 32 poz.
    Sygnatura GBL: 305,029

    Hasła klasyfikacyjne GBL:
  • farmacja
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Lovastatin, the drug used for the treatment of hypercholesterolemia, has previously been reported to exert antitumor activity in experimental murine models. Byturate and butyric acid derivatives are well known to induce differentiation and apoptosis of tumour cells and also have recently gained acceptance as potentaial anticancer agents. In this study, we examined the antitumor effects of the combination of lovastatin and butyrate or its prodrug tributyrin in vitro and in vivo against a murine Lewis lung carcinoma (3LL). This combination therapy showed synergistic antitumor activity against 3LL cells in vitro. These effects were at least in part due to apoptosis induction that occurred after 12 hr of incubation with lovastatin and butyrate and was preceded by changes in cell cycle distribution of treated cells and expression of p21, p53 and cyclin D 1. Remarkably, a systemic treatment of syngeneic mice inoculated with 3LL cells with both drugs resulted in significant tumour growth retardation.


    78/2523

    Tytuł oryginału: Accuracy of transcranial color Doppler ultrasonography in the diagnosis of middle cerebral artery spasm determined by receiver operating characteristic analysis.
    Autorzy: Mariak Zenon, Krejza Jarosław, Świercz Mirosław, Kordecki Kazimierz, Lewko Janusz
    Źródło: J. Neurosurg. 2002: 96 (2) s.323-330, il., tab., bibliogr. 68 poz.
    Sygnatura GBL: 301,435

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Object. The value of transcranial Doppler ultrasonography for the detection of middle cerebral artery (MCA) spasm has been asserted. None of the published studies, however, has adequately scrutinized the overall diagnostic accuracy of this procedure. There are only sporadic reports concerning the utility of transcranial color Doppler (TCCD) ultrasonography, although this method has been proved to be more precise. In this study the authors attempted to estimate the performance of TCD ultrasonography in detecting MCA narrowing by using receiver operating characteristic (ROC) curve analysis, based on TCCD studies obtained in a relatively large, randomly selected population of patients. Methods. Transcranial color Doppler ultrasonography studies were obtained in 100 consecutive patients (54 men and 46 women ages 18-74 years, median age 50 years) routinely referred by neurosurgeons for intraarterial angiography. The M1 segment of the MCA was insonated using a 2.5-MHz probe via a temporal acoustic window, and angle-corrected flow velocities were obtained. Angiographically depicted vasospasm was graded as none, mild (ó 25 p.c. vessel caliber reduction), and moderate to severe ( 25 p.c. vessel caliber reduction). The effectiveness of TCCD ultrasonography in diagnosing MCA spasm was evaluated by calculating the areas under the ROC curves (Az). Of the 200 MCAs examined, 173 were successfully visualized with the aid of TCCD ultrasonography. Mild vasospasm was angiographically diagnosed in 15 arteries and moderate-to-severe vasospasm in 28...


    79/2523

    Tytuł oryginału: Expression of FasL gene in T cells of renal allograft recipients.
    Autorzy: Kasprzycka Monika, Kłodos Konrad, Nowaczyk Maria, Wyzgał Janusz, Podobińska Iwona, Durlik Magdalena, Górski Andrzej
    Źródło: Immunol. Lett. 2002: 80 (1) s.9-13, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 312,663

    Hasła klasyfikacyjne GBL:
  • genetyka
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: FasL molecule expressed on activated T cells induces apoptosis in Fas-expressing cells. It is possible that apoptosis induced by FasL is involved in the process of allograft destruction brought about by infiltrating T cells. The aim of our study was to evaluate expression of FasL gene in peripheral blood T cells of renal allograft recipients (RAR). We have studied 25 patients: 16 with uneventful stable course (RAR-S) and nine during biopsy proven chronic rejection (RAR-CH). The relative expression of FasL mRNA compared with that of á-actin was established by semi-quantitive RT-PCR. We have found that FasL gene expression was significantly increased in T cells of RAR-CH compared to RAR-S (P 0.01). Our results suggest that T cells expression of FasL gene is increased during chronic rejection. Therefore, this phenomenon may pay a role in allograft injury associated with that process. Further studies are needed to unravel possible clinical consequences of observed differences in T cell expression of FasL.


    80/2523

    Tytuł oryginału: Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women.
    Autorzy: Rachoń D., Myśliwska J., Suchecka-Rachoń K., Więckiewicz J.
    Źródło: J. Endocrinol. 2002: 172 (2) s.387-395, il., tab., bibliogr. s. 393-395
    Sygnatura GBL: 310,833

    Hasła klasyfikacyjne GBL:
  • immunologia
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Various hormones can influence the expression of interleukin-6 (IL-6) and oestrogens are the most extensively studied. There is, however, controversy about the nature of the IL-6 secreted by human cells and its regulation by 17á-oestradiol. The aim of this work was to clarify whether oestrogen deprivation after menopause may contribute to an enhanced IL-6 production by peripheral blood mononuclear cells (PBMC) in postmenopausal women. Twenty-two healthy postmenopausal women, age range 45-63 years with clinical symptoms of oestrogen deficiency were enrolled in the study. The control group consisted of 16 healthy young women, age range 22-31 years, with regular menses and who were not taking oral contraceptives. Levels of IL-6 in the sera and PBMC culture supernatants were measured by the biological B9 cell-proliferation assay and expression of the IL-6 gene in non-stiulated PBMC was detected by RT-PCR. The effect of 17á-oestradiol on spontaneous IL-6 production by the PBMC of postmenopausal women was also studied in vitro and in vivo. Seventeen out of the twenty-two postmenopausal women were given hormonal replacement therapy of 50 ćg 17á-oestradiol/day transdermally and the spontaneous production of IL-6 by the PBMC was analysed after 6 and 12 months of treatment. The postmenopausal women had significantly higher serum levels of IL-6 than the young controls. The spontaneous production of IL-6 by non-stimulated PBMC into the culture supernatants was also significantly higher in the postmenopausal women compared with the young...


    81/2523

    Tytuł oryginału: Myocardial perfusion correlates with improvement of systolic function of the left ventricle after CABG. Dobutamine echocardiography and Tc-99m-MIBI SPECT study.
    Autorzy: Paluszkiewicz L., Kwinecki P., Jemielity M., Dyszkiewicz W[ojciech], Cieśliński A., Szyszko A.
    Źródło: Eur. J. Cardiothorac. Surg. 2002: 21 (1) s.32-35, tab., bibliogr. 20 poz. - 14 Doroczne Spotkanie Europejskiego Towarzystwa Chirurgii Klatki Piersiowej i Serca Frankfurt 07-11.10. 2000
    Sygnatura GBL: 312,899

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: The aim of the study was to assess the effect of surgical revascularization [coronary artery bypass grafting (CABG)] on systolic function and perfusion of the left ventricle using dobutamine echocardiography (DE) and Tc-99m-MIBI SPECT (SPECT). Methods: There were 32 patients mean age 52.2 ń 7.2 years in whom DE and SPECT were performed before and 3-4 months after CABG using standard protocols. Wall motion score index (WMSI) and perfusion index (PI) were calculated. Results: Significant improvement of WMSI at rest (1.44 ń 0.46 vs 1.33 ń 0.41; P = 0.03) as well as after maximal dose of dobutamine (1.49 ń 0.42 vs 1.30 ń 0.44; P = 0.02) was observed after CABG as compared to preoparative examination. Similar relation was observed during SPECT study. Perfusion index diminished significantly after revascularization during rest acquisition (2.19 ń 0.71 vs 1.93 ń 0.70; P = 0.0008) and after Dipirydamole administration (2.73 ń 0.73 vs 2.20 ń 0.69; P = 0.0001) as compared to preoperative examination. We found correlation between PI and WMSI at rest before CABG (R = 0.46; P = 0.01). PI after Dipirydamole and WMSI after maximal dose of Dobutamine before CABG (R = 0.37; P = 0.04), PI and WMSI at rest CABG (R = 0.39; P = 0.03), PI after Dipirydamole and WMSI after dobutamine after CABG (R = 0.38; P = 0.03). Conclusions: Surgical revascularization significantly improves both perfusion and contractility. Increased perfusion after CABG correlates with improvement of systolic function of the left ventricle.


    82/2523

    Tytuł oryginału: A new type of mixed anhydride and its applications to the synthesis of 7-substituted 8-chloro-5,5-dioxoimidazo[1,2-b][1,4,2]benzodithiazines with in vitro antitumor activity.
    Autorzy: Brzozowski Zdzisław, Sączewski Franciszek
    Źródło: J. Med. Chem. 2002: 45 (2) s.430-437, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 312,133

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: A new series of 8-chloro-5,5-dioximidazo[1,2-b][1,4,2]benzodithiazine derivatives 8-25 with heteroaryloxycarbonyl or heteroarylcarbamoyl substituents at position 7 have been synthesized as potential antitumor agents. In this procedure a novel type of mixed anhydride 7 was prepared from 8-chloro-5,5-dioxoimidazo[1,2-b][1,4,2]benzodithiazine-7-carboxylic acid 6 and methanesulfonyl chloride, which in turn was condensed either with heteroarylamines or heteroarylhydroxy compounds. All the compounds prepared were screened at the National Cancer Institute (NCI) for their activities against a panel of 60 tumor cell lines, and relationships between structure and antitumor activity in vitro are discussed. The amides 8, 10, 12, 13, 21, and ester 25 were inactive, whereas the other compounds exhibited rather moderate activity against one or more human tumor cell lines. The prominent compound with remarkable activity (log GI50 -8) and selectivity for the leukemia HL-60(TB) cell line was 2-methyl-8quinolyl 8-chloro-5,5-dioximidazo[1,2-b][1,4,2]benzodithiazine-7-carboxylate 24.


    83/2523

    Tytuł oryginału: Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups.
    Autorzy: Gasowski Jerzy, Fagard Robert H., Staessen Jan A., Grodzicki Tomasz, Pocock Stuart, Boutitie Florent, Gueyffier Francois, Boissel Jean-Pierre
    Źródło: J. Hypertens. 2002: 20 (1) s.145-151, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,132

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective. Although cirrent guidelines rest exclusively on the measurement of systolic and diastolic blood pressures, the arterial pressure wave is more precisely described as consisting of a pulsatile (pulse pressure) and a steady (mean pressure) component. This study explored the independent roles of pulse pressure and mean pressure as predictors of mortality in a wide range of patients with hypertension. Design and methods. This meta-analysis, based on individual patient data, has combined results from the control groups of seven randomized clinical trials conducted in patients with systolo-diastolic or isolated systolic hypertension. The relative hazard rates associated with pulse pressure and mean pressure were calculated using Cox's proportional hazard regression models with stratification for the seven trials and with adjustment for sex, age, smoking and the other pressure. Results. A 10 mmHg wider pulse pressure at baseline, which corresponds to approximately one-half of its standard deviation, was independently associated with an increase in risk by 6 p.c. for total mortality (P = 0.001), 7 p.c. for cardiovascular mortality (P = 0.01), and 7 p.c. for fatal coronary accidents (P = 0.03). The corresponding increase in risk of fatal stroke was similar (+ 6 p.c., P = 0.27) but there were too few strokes to reach statistical significance. In similar analyses, mean pressure was not identified as an independent predictor of these outcomes. Significant interactions of pulse pressure or mean pressure with age suggested that the prognostic power of pulse pressuer for fatal stroke was more important at higher age (P = 0.04), whereas the prognostic power of mean pressure for coronary mortality was greatest in the young (P = 0.01)...


    84/2523

    Tytuł oryginału: Inhibition of N-methyl-D-aspartic acid-nitric oxide synthase in rat hippocampal slices by ethanol. Evidence for the involvement of tetrahydrobiopterin but not lipid peroxidation.
    Autorzy: Czapski Grzegorz A., Sun Grace Y., Strosznajder Joanna B.
    Źródło: J. Biomed. Sci. 2002: 9 (1) s.3-9, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,488

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The ionotropic glutamatergic receptor system, especially the subtype mediated by N-methyl-D-aspartic acid (NMDA), is known to exhibit special sensitivity to the effect of ethanol. This is due partly to the ability of ethanol to modulate the production of nitric oxide through the NMDA-nitric oxide synthase (NOS) pathway. In this study, we examined the effects of ethanol on basal and NMDA-stimulated NOS activity in rat hippocampal slices by measuring the conversion of [**14C]-arginine into [**14C]-citrulline in an incubation system containing the necessary cofactors. Stimulation of hippocampal slices with NMDA (100 ćM) enhanced NOS activity by 43 p.c. (n = 12). Although ethanol did not alter NOS activity when added to the incubation system during NMDA stimulation, it dose-dependently inhibited NMDA-NOS activity when added to the slices during the 90-min preincubation period. Further assay of NOS activity with brain cytosolic fraction indicated an inhibitory effect of ethanol (200 mM) when the assay was carried out in the absence of exogenous tetrahydrobiopterin (BH4), a redox-active cofactor for NOS. Incubation of brain homogenates resulted in a time-dependent increase in the levels of lipid peroxidation products, but ethanol did not further enhance these products. Taken together, these results providence evidence for the role of BH4 but not oxidative stress in the inhibitory effect of ethanol on NMDA-NOS activity in rat hippocampal slices.


    85/2523

    Tytuł oryginału: Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and Leishmaniasis.
    Autorzy: Zhang Peng, Nicholson Diarmuid E., Bujnicki Janusz M., Su Xinzhuan, Brendle James J., Ferdig Michael, Kyle Dennis E., Milhous Wilbur K., Chiang Peter K.
    Źródło: J. Biomed. Sci. 2002: 9 (1) s.34-40, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,488

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Methionine aminopeptidase 2(MetAP2) is responsible for the hydrolysis of the initiator methionine molecule from the majority of newly synthesized proteins. We have cloned the MetAP2 gene from the malaria parasite Plasmodium falciparum (PfMetAP2; GenBank accession number AF348320). The cloned PfMetAP2 has no intron, consists of 1,544 bp and encodes a protein of 354 amino acids with a molecular mass of 40,537 D and an overall base composition of 72.54 p.c. A + T. PfMetAP2 has 40 p.c. sequence identity with human MetAP2 and 45 p.c. identity with yeast MetAP2, and is located in chromosome 14 of P. falciparum. The three-dimensional structure of PfMetAP2 has been modeled based on the crystal structure of human MetAP2, and several amino acid side chains protruding into the binding pocket that differ between the plasmodial and human enzyme have been identified. The specific MetAP2 inhibitors, fumagilin and TNP-470, potently blocked in vitro growth of P. falciparum and Leishmania donovani, with IC50 values similar to the prototype drugs. Furthermore, in the case of P. falciparum, the chloroquine-resistant strains are equally susceptible to these two compounds.


    86/2523

    Tytuł oryginału: Intrapartum cardiotocography and fetal pulse oximetry in assessing fetal hypoxia.
    Autorzy: Leszczyńska-Gorzelak B., Poniedziałek-Czajkowska E., Oleszczuk J.
    Źródło: Int. J. Gynecol. Obstet. 2002: 76 (1) s.9-14, tab., bibliogr. 20 poz.
    Sygnatura GBL: 312,925

    Hasła klasyfikacyjne GBL:
  • pediatria
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Objectives: A retrospective analysis of short-term variability (STV), a cardiotocography (CTG) parameter, in relation to fetal blood saturation values (FSpO2) obtained by fetal pulse oximetry. Methods: The study included 26 healthy pregnant women monitored continuously during delivery with both cardiotocography and fetal pulse oximetry. Results: Lower FSpO2 values were observed in the group showing STV levels ó 6.0 ms in the 1st stage of labor (44.7 ń 3.46 p.c. vs. 49.2 ń 1.8 p.c.), but this result was not statistically significant. In the 2nd stage of labor, FSpO2 values in the group with STV levels ó 6.0 ms were significantly lower than those with STV levels 6.0 ms (34.4 ń 2.9 p.c. vs. 43 ń 7.2 p.c.; P 0.001). A positive correlation was found between STV levels ó 6.0 ms and mean FSpO2 values in the 2nd stage of labor. Conclusions: 1. A significant relationship was observed between short-term variability in the cardiotocographic records and fetal blood saturation levels in the 2nd stage of labor. 2. Fetal pulse oximetry can be valuable in assessing fetal wellbeing, especially when CTG records are abnormal.


    87/2523

    Tytuł oryginału: Apoptosis in the first trimester human placenta: the role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodelling.
    Autorzy: Jerzak Małgorzata, Bischof Paul
    Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 100 (2) s.138-142, il., bibliogr. 56 poz.
    Sygnatura GBL: 305,582

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Apoptosis has been proposed as a mechanism maintaining immune privilege. Expression of Fas ligand (FasL) by the human trophoblast has been recently accepted as a mechanism providing protection against the lytic action of activated decidual immune cells expressing Fas receptor (FasR). Therefore, the purpose of this review was determine the role of apoptosis in early pregnancy maintenance according to the latest literature. We used Medline literature search. The data suggest that apoptosis may serve as a previously unsuspected mechanism that induces tolerance of the foetal allograft against maternal immune system. Apoptosis of activated maternal immune cells occurs in the human decidua mainly through Fas-FasL or receptor for TNF-related apoptosis-inducing ligand (TRAIL-R)-TNF-related apoptosis-inducing ligand (TRAIL) signalling. This might be a defence mechanism against rejection of the foetal allograft by the maternal immune system. In addition, in this review contribution of programmed cell death to placental cell turnover and remodelling during first trimester of pregnancy is also discussed.


    88/2523

    Tytuł oryginału: Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of low molecular weight heparin. Gynecological ward retrospective analysis.
    Autorzy: Cyrkowicz Andrzej
    Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 100 (2) s.223-226, tab., bibliogr. 20 poz.
    Sygnatura GBL: 305,582

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Objectives: To compare the frequency of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing gynecological operations without low molecular weight heparin (LMWH) prophylaxis and those receiving such prophylaxis. Design: Retrospective, hospital record-based study. Material and methods: About 1785 consecutive patients without LMWH prophylaxis and 1871 ones treated with nadroparin (Fraxiparine) 7500 ICU s.c. 2 h before the operation and repeated daily for 5-7 days or until the patient was fully mobile. DVT was diagnosed on the basis of clinical symptoms and ultrasound examination, and PE clinical symptoms, gasometric data, electrocardiography and chest X-ray. Results: Among the patients without prophylaxis, four cases of PE occurred (0.22 p.c.), two fatal (0.11 p.c.), 13 cases of proximal DVT (0.72 p.c.) and 41 distal DVT complications (2.3 p.c.). In LMWH, group 3 proximal DVT (0.16 p.c.) and 18 distal DVT (0.96 p.c.) developed but there were no clinically expressed pulmonary embolism. According to the Fisher's exact test, the difference between the complications in the analyzed groups is significant P 0.05. Conclusions: The perioperative applying of LMWH to prevent DVT in the patients operated on gynecologically is effective.


    89/2523

    Tytuł oryginału: Immunopharmacological potential of selective phosphodiesterase inhibition.[P.] 1: Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-ŕ) biosynthesis in alveolar epithelial cells.
    Autorzy: Haddad John J., Land Stephen C., Tarnow-Mordi William O., Zembala Marek, Kowalczyk Danuta, Lauterbach Ryszard
    Źródło: J. Pharmacol. Exp. Ther. 2002: 300 (2) s.559-566, il., bibliogr. s. 565-566
    Sygnatura GBL: 310,547

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: In an attempt to elaborate in vitro on a therapeutic strategy that countracts an inflammatory signal, we previously reported a novel immunopharmacological potential of glutathione, an antioxidant thiol, in regulating inflammatory cytokines. In the present study, we investigated the hypothesis that selective regulation of phosphodiesterases (PDEs), a family of enzymes that controls intracellular cAMP/cGMP degradation, differentially regulates proinflammatory cytokines. Selective PDE1 inhibition (8-methoxymethyl-3-isobutyl-1-methylxanthine) blockaded lipopolysaccharide-endotoxin (LPS)-mediated biosynthesis of interleukin (IL)-6, but this pathway had no inhibitory effect on tumor necrosis factor-ŕ (TNF-ŕ). Furthermore, inhibition of PDE3 (amrinone) abolished the effect of LPS on IL-6, but attenuated TNF-ŕ production. Reversible competitive inhibition of PDE4 (rolipram) exhibited a potent inhibitory effect on IL-6 and a dual, biphasic (excitatory/inhibitory) effect on TNF-ŕ secretion. Blockading PDE5 (4-[3',4'-(methylenediox)benzyl]amino-6-methoxyquinazoline) showed a high potency in reducing IL-6 production, but in a manner similar to the inhibition of PDE4, exhibited a biphasic effect on TNF-ŕ biosynthesis. Simultaneous inhibition of PDE5, 6 and 9 (zaprinast), purported to specifically elevate intracellular cGMP, reduced, in a doseindependent manner, IL-6 and TNF-ŕ biosynthesis. Finally, nonselective inhibition of PDE by pentoxyfylline suppressed LPS-mediated secretion of IL-6 and TNF-ŕ. The involvement of specific PDE isoenzymes in differentially regulating LPS-mediated inflammatory cytokine biosynthesis indicates a novel approach to unravel the potential therapeutic targets that these isozymes constitute during the progression of inflammation within the respiratory epithelium.


    90/2523

    Tytuł oryginału: Immunopharmacological potential of selective phosphodiesterase inhibition. [P.] 2: Evidence for the involvement of an inhibitory-kB/nuclear factor-kB-sensitive pathway in alveolar epithelial cells.
    Autorzy: Haddad John J., Land Stephen C., Tarnow-Mordi William O., Zembala Marek, Kowalczyk Danuta, Lauterbach Ryszard
    Źródło: J. Pharmacol. Exp. Ther. 2002: 300 (2) s.567-576, il., tab., bibliogr. s. 575-576
    Sygnatura GBL: 310,547

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: In this report we investigated the immunopharmacological role of selective and nonselective phosphodiesterase (PDE) inhibition in regulating the inhibitory-kB (IkB-ŕ)/nuclear factor-kB (NF-kB) signally transduction pathway. In fetal alveolar type II epithelial cells, PDE blockade at the level of the diverging cAMP/cGMP pathways differentially regulated the phosphorylation and degradation of IkB-ŕ, the major cytosolic inhibitor of NF-kB. Whereas selective inhibition of PDEs 1, 3, and 4, by the action of 8-methoxymethyl-3-isobutyl-1-methylxanthine, amrinone, and rolipram, respectively, exhibited a tendency to augment the translocation of NF-kB1 (p50), RelA (p65), RelB (p68), and c-Rel (p75), selective blockade of PDE 5, 6, and 9, by the action of 4-[3',4'=(methylenedioxy)benzyl]amino)-6-methoxyquinazoline and zaprinast, attenuated lipopolysaccharide-endotoxin (LPS)-mediated NF-kB translocation. Pentoxifilline, a nonspecific PDE inhibitor, reversed the excitatory effect of LPS on NF-kB subunit nuclear localization, in a dosedependent manner. Furthermore, analysis of NF-kB activation under the same conditions revealed a biphasic effect mediated by LPS. PDEs 1, 3, and 4 inhibition was associated with upregulating NF-kB transcriptional activity. In contrast, blockading the activity of PDEs 5, 6, and 9 negatively attenuated LPS-mediated NF-kB activation, similar to the effect of 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione (pentoxifulline). These results indicate that selective and nonselective interference with the control of the dynamic equilibrium of cyclic nucleotides via PDE isoenzyme regulation represents an immunoregulatory mechanism that requires the differential, biphasic targeting of the IkB-ŕ/NF-kB pathway.


    91/2523

    Tytuł oryginału: Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis.
    Autorzy: Szamatowicz J., Laudański P., Tomaszewska I.
    Źródło: Hum. Reprod. 2002: 17 (2) s.284-288, il., tab., bibliogr. s. 287-288
    Sygnatura GBL: 313,265

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: Matrix metalloproteinases (MMPs) are a family of endopeptidases which play a role in the degradation and turnover of extracellular matrix proteins. Their action is regulated by specific tissue inhibitors called tissue inhibitors of metalloproteinases (TIMPs). Methods: We measured the concentrations of total and active MMP-9 in peritoneal fluid of infertile women with mild or moderate endometriosis (n = 22) and compared them with those in a control group of infertile patients (n = 21). Results: We found that the mean (ń SD) total concentrations of MMP-9 in the peritoneal fluid of patients with endometriosis was 6.2 ń 1.8 ng/ml, in comparison with 2.9 ń 2.6 ng/ml in the control group (P = 0.001). Concenrations of active MMP-9 did not differ significantly between the groups. The concentrations of TIMP-1, after logarithmic transformation, were significantly lower (P = 0.017) in endometriotic peritoneal fluids than in peritoneal fluid of control women, 1.02 ń 0.21 ng/ml and 1.16 ń 0.18 ng/ml respectively. No correlation between stage of disease, steroid hormone concentration, MMP-9 (total and active) and TIMP-1 was found. Conclusions: These results suggest that a disturbed equilibrium exists between MMP-9 and TIMP-1 in peritoneal fluid of women with endometriosis. This may play an important role in the pathogenesis of the disease.


    92/2523

    Tytuł oryginału: HA 1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Caý+ -mediated apoptosis through a protein kinase A-independent mechanism.
    Autorzy: Matuszyk Janusz, Cebrat Małgorzata, Kalas Wojciech, Strzadała Leon
    Źródło: Int. Immunopharmacol. 2002: 2 (4) s.435-442, il., bibliogr. 20 poz.
    Sygnatura GBL: 313,577

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Our revious reports showed that thymic lymphomas arising in TCR transgenic mice are resistant to Caý+ -mediated apoptosis. Here we show that induction of apoptosis in thymic lymphomas involves a process that is cAMP-mediated and which depends on the activation of protein kinase A (PKA) despite the lower level of PKA type I in these lymphomas compared to thymocytes. Further, we show that treatment of the lymphomas with HA1004, a serine/threonine protein kinase inhibitor, restores their susceptibility to ionomycin-induced apoptosis. Results indicate that HA1004-induced restoration of sensitivity to ionomycin proceeds through a PKA-independent mechanism. Moreover, activation of PKA instead of its inhibition induces apoptosis of lymphoma cells.


    93/2523

    Tytuł oryginału: Lactoferrin immunomodulation of DTH response in mice.
    Autorzy: Actor Jeffrey K., Hwang Shen-An, Olsen Margaret, Zimecki Michał, Hunter jr Robert L., Kruzel Marian L.
    Źródło: Int. Immunopharmacol. 2002: 2 (4) s.475-486, il., tab., bibliogr. 51 poz.
    Sygnatura GBL: 313,577

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Improved nontoxic adjuvants, especially adjuvants capable of inducing cell-mediated immunity (CMI), are needed for research in immunology and for development of human and veterinary vaccines. Bovine Lactoferrin, an effector molecule shown to directly participate in host defense, was assessed at various concentrations as an adjuvant component for induction of DTH responses to sheep red blood cells (SRBC). Subcutaneous immunization with Lactoferrin enhanced delayed type hypersensitivity (DTH) in CBA mice in a dose-dependent fashion; DTH responses were most significantly increased when sensitization was accomplished using Lactoferrin at 50 ćg/dose and 250 ćg/dose. Furthermore, Lactoferrin admixed with suboptimal dose of SRBC enhanced DTH responses by over 17-fold. Peritoneal cells collected from mice intraperitoneally injected with a 100 ćg/dose of Lactoferrin demonstrated modest, but significant, production of TNF-ŕ, IL-12 and MIP-1ŕ, when cultured in vitro, compared to saline-injected controls. J774A.1 murine macrophages stimulated with Lactoferrin resulted in increased TNF-ŕ protein production, and upregulated IL-12 and IL-15 mRNA. Levels of message for chemokins MIP-1ŕ and MIP-2 were also increased in a dose-dependent way. Taken together, these results indicate that Lactoferrin as an adjuvant may stimulate macrophages to generate a local environment likely to push immune responses towards development and maintenance of CMI.


    94/2523

    Tytuł oryginału: Nitric oxide and convulsions in 4-aminopyridine-treated mice.
    Autorzy: Tutka Piotr, Młynarczyk Małgorzata, Żółkowska Dorota, Kleinrok Zdzisław, Wielosz Marian, Czuczwar Stanisław J.
    Źródło: Eur. J. Pharmacol. 2002: 437 (1/2) s.47-53, il., tab., bibliogr. s. 52-53
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: We studied whether N**G-nitro-L-arginine (NNA), an inhibitor of nitric oxide (NO) synthase as well as L-arginine and molsidomine, two agents elevating NO, influenced convulsions caused by 4-aminopyridine, a K+ channel blocker in mice. NNA, in a dose known to decrease level of NO (40 mg kg -**1), enhanced the susceptibility to intraperitoneal (i.p.) and intracerebroventricular (i,c,v,) 4-aminopyride. L-arginine (500 mg kg -**1) and molsidomine (20 mg kg -**1) alone did not influence 4-aminopyridine-induced seizure activity. Surprisingly, the proconvulsant effect of NNA upon clonic and tonic seizures was potentiated by molsidomine (20 mg kg -**1). No influence of L-arginine on the proconvulsant effect of NNA was found. Taking into account the proconvulsant effect of NNA, an involvement of NO-mediated events in the mechanism of convulsive activity of 4-aminopyridine might by postulated, However, the ineffectiveness of L-arginine and molsidomine to suppress the convulsive activity of 4-aminopyridine as well as a paradoxical potentiation of the proconvulsant effect of NNA by molsidomine seem to exclude the impact of NO pathway on 4-aminopyridine-induced convulsions in mice. Our data suggest that the proconvulsant effect of NNA in this seizure model is caused by other, not related to NO, mechanisms.


    95/2523

    Tytuł oryginału: Decortication in chronic pleural empyema - effect on lung function.
    Autorzy: Rzyman Witold, Skokowski Jan, Romanowicz Grzegorz, Lass Piotr, Dziadziuszko Rafał
    Źródło: Eur. J. Cardiothorac. Surg. 2002: 21 (3) s.502-507, il., bibliogr. 24 poz.
    Sygnatura GBL: 312,899

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: The aim of the present study is to evaluate the lung function before and after the lung decortication in patients with chronic pleural empyema (CPE).Methods: Twenty-six patients with diagnosis of CPE were evaluated in a prospective manner by lung perfusion scintigraphy, blood gas analysis and spirometry before and 35 weeks (ń 17) after the lung decortication. Results: Preoperative scintigraphy showed reduction of lung perfusion on the affected side to 24.5 p.c. (ń 12.6 p.c.) in 11 right side empyemas (predicted value 55 p.c.) and to 18 p.c. (ń 8 p.c.) in 15 left side empyemas (predicted value 45 p.c.). The postoperative measurements showed improvement in perfusion to 45.2 p.c. (ń 7.7 p.c.) in patients with right side empyema and 34.1 p.c. (ń 8.5 p.c.) with the left side affection. The preoperative vital capacity (VC) was reduced to 62.3 p.c. (ń 13.8 p.c.) of the predicted value and forced expiratory volume in 1 s (FEV1) to 50 p.c. (ń 15.5 p.c.) of the predicted value. Postoperatively, slight improvement was achieved to 79.8 p.c. (ń 12.9 p.c.) for VC and 69.2 p.c. (ń 12.7 p.c.) for FEV1. Blood gas analysis showed decreased value in majority of the patients before operation and significant improvement in postoperative evaluation: Conclusion: Perfusion and spirometry improves significantly in patients with CPE after the lung decortication but function of the affected lung remains impaired. There was no influence of the age, gender, side of the disease, bacteriology or duration of the empyema before operation on lung function.


    96/2523

    Tytuł oryginału: 2- Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice.
    Autorzy: Borowicz Kinga K., Łuszczki Jarogniew, Czuczwar Stanisław J.
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (2) s.173-179, il., tab., bibliogr. [28] poz.
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: 2-Chloroadenosine (0.25 - 1 mg/kg) significantly raised the threshold for electroconvulsions in mice. This preferential adenosine A1 receptor agonist (at 0.125 mg/kg) significantly potentiated the protective activity of carbamazepine against maximal electroshock-induced seizures in mice. 2-Chloroadenosine (1 mg/kg) showed also anticonvulsive efficacy against pentylenetetrazol-evoked seizures, raising the CD50 vale for pentylenetetrazol from 77.2 to 93.7 mg/kg. The drug (at 0.5 mg/kg) significantly enhanced the protective action of clonazepam in this test, decreasing its ED50 value from 0.033 to 0.011 mg/kg. Moreover, aminophylline, a non-selective adenosine receptor antagonist (5 mg/kg), and 8-cyclopentyl-1,3-dimethylxanthine (8-CPX), a selective A1, adenosine receptor antagonist (5 mg/kg) reversed the 2-chloroadenosine (0.125 mg/kg)-induced enhancement of the protective activity of carbamazepine and clonazepam. 2-Chloroadenosine administered alone or combined with antiepileptic drugs, caused neither motor nor long-term memory impairment. Finally, the adenosine A1 agonist did not change the free plasma concentration of antiepileptic, so a pharmacokinetic factor is not probable. Summing up, 2-chloroadenosine potentiated the protective activity of both carbamazepine and clonazepam, which seems to be associated with the enhancement of purinergic transmission mediated through adenosine A1 receptors.


    97/2523

    Tytuł oryginału: The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. P. 1: Reduction of cytostatic effects of quinacrine mustard by caffeine.
    Autorzy: Kapuściński Jan, Ardelt Barbara, Piosik Jacek, Zdunek Małgorzata, Darzynkiewicz Zbigniew
    Źródło: Biochem. Pharmacol. 2002: 63 (4) s.625-634, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 304,395

    Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Recently, accumulated statistical data indicate the protective effect of caffeine consumption against several types of cancer diseases. There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations is based on biological activation of such carcinogens by cytochromes that are also known for metabolism of caffeine. However, there is also numerous data indicating reverse effect on cytotoxicity of anticancer drugs that inhibit the action of topoisomerase I (e.g. Camptothecin or Topotecan) and topoisomerase II inhibitors (e.g. Doxorubicin, Mitoxantrone or mAMSA). In this work we tested the hypothesis that the caffeine protective effect is the result of sequestering of aromatic mutagens by formation of stacking (ă - ă) complex. As the models for the study we have chosen two well-known mutagens, that do not require metabolic activation: quinacrine mustard (QM, aromatic, heterocyclic nitrogen mustard) and mechlorethamine (NM2, aliphatic nitrogen mustard). The flow cytometry study of these agents' action on the cell cycle of HL-60 cells indicated that caffeine prevents the cytotoxic action of QM, but not that of NM2. The formations of stacking complexes of QM with caffeine were confirmed by light absorption, calorimetric measurements and by molecular modeling calculation. Using the statistical thermodynamics calculations we calculated the "neighborhood" association constant (KAC = 59 ń 2 M**-1) and enthalpy change (DeltaH**0' = -116 cal mol**-1); the favorable entropy change of complex formation (DeltaS**0' = 7.72 cal mol**-1 K**-1, ...


    98/2523

    Tytuł oryginału: The modulation by xanthines of the DNA-damaging effect of polycyclic aromatic agents. P. 2: The stacking complexes of caffeine with doxorubicin and mitoxantrone.
    Autorzy: Piosik Jacek, Zdunek Małgorzata, Kapuściński Jan
    Źródło: Biochem. Pharmacol. 2002: 63 (4) s.635-646, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 304,395

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Recently accumulated statistical data indicate the protective effects of caffeine consumption against several types of cancer diseases. There are also reports, about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations of this phenomenon is based on biological activation of such carcinogens by cytochromes that are also known for metabolism of caffeine. In the accompanying paper [Kapuścinski et al., this issue] we provide evidence (flow cytometry and the cell cycle analysis) that the cytostatic effects of caffeine (CAF) on two DNA alkylating agents, which do not require the biological activation, depend on their ability to form stacking (ă - ă) complex. In this study, we use physicochemical techniques (computer aided light absorption and microcalorimetry), and molecular modeling to examine previously published qualitative data. This is published both by our and other group's data, indicates that CAF is able to modify the cytotoxic and/or cytostatic action of the two well known antitumor drugs doxorubicin (DOX) and mitoxantrone (MIT). To obtain the quantitative results from the experimental data we used the statistical-thermodynamical model of mixed aggregation, to find the association constants KAC of the CAF-drug interaction (128 ń 10 and 356 ń 21 M**-1 for DOX-CAF and MIT-CAF complex formation, respectively). In addition, the favorable enthalpy change of CAF-MIT (DeltaH = -11.3 kcal/mol) was measured by microcalorimetry titration. The molecular modeling (semi-empirical and force field method)...


    99/2523

    Tytuł oryginału: Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias.
    Autorzy: Konopka Bożena, Paszko Zygmunt, Janiec-Jankowska Aneta, Goluda Marian
    Źródło: Cancer Lett. 2002: 178 (1) s.43-51, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 306,023

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometrial carcinomas. In 45.8 p.c. (27/59) of carcinomas, 36 somatic mutations were detected in PTEN gene. In seven carcinomas, two mutations and in one carcinoma there mutations coexisted simultaneously. Moreover in 33.3 p.c. (2/6) of hyperplasia cases mutations were shown. Most identified mutations (57.9 p.c.) were present in exons 5 and 8, less frequently in exons 2 (15.8 p.c.) and 7 (13.2 p.c.) and they were least frequent in exons 1 and 3 (5.3 p.c. each). No mutations were found in exons 4, 6 and 9. Of all identified mutations, 73.7 p.c. of these resulting in truncated protein were present due to deletions, insertions and nonsense mutations. Missense mutations accounted for 13.2 p.c. of mutations and they were present only in exon 5. One point mutation (2.5 p.c.) was in intronic splice site. The remaining 10.5 p.c.of mutations were neutral polymorphisms. No statistically significant correlation were found between the frequency of PTEN gene mutations and the clinical stage of endometrial carcinomas. However, evident statistically significant, reverse correlation were observed between the frequency of mutations and the grade of morphological differentation of the diseases (Xý = 7.2393, ŕ = 0.0071). In conclusion, our data support the view that PTEN gene mutations are frequent events involved in development of endometrial carcinomas in women.


    100/2523

    Tytuł oryginału: Accuracy of linear endoscopic ultrasonography in the evaluation of patients with suspected common bile duct stones.
    Autorzy: Kohut M., Nowakowska-Duława E., Marek T., Kaczor R., Nowak A.
    Źródło: Endoscopy 2002: 34 (4) s.299-303, tab., bibliogr. 28 poz.
    Sygnatura GBL: 305,439

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background and study aims: Endoscopic ultrasonography (EUS) with radial scanning is an efficient diagnostic tool where there is suspicion of common bile duct (CBD) stones. Little is known about the use of linear EUS in this condition. The aim of this study was to evaluate the diagnostic efficiency of linear EUS in a large group of patients suspected to have bile duct stones, using endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy and exploration of the CBD using a Dormia basket, or surgical choledochotomy with choledochoscopy, as diagnostic "gold standards". Patients and methods: 134 patients with clinical suspecion of CBD stones were included in the study and prospectively evaluated, using EUS, and ERCP with endoscopic sphincteroctomy (127 patients), or choledochotomy with choledochoscopy where ERCP was unsuccessful (seven patients). EUS was done before ERCP using an echo endoscope (Pentax FG 32 UA; 5 - 7.5 MHz) and Hitachi EUB 405 ultrasound machine. ERCP was done using the TFJ 100 or TJ 20 Olympus duodenoscope. ERCP was carried out within a mean of 2 days after EUS. The longest time between EUS and ERCP was 3 days. The examiners were binded to the results of the other method used. Results: CBD stones were found in 91 (68 p.c.) patients at ERCP with ES or at surgery. The correct diagnosis was established by EUS in 85 patients. The remaining 43 patients without CBD stones were correctly diagnosed in 41 cases by means of EUS, giving an accuracy of 94 p.c., specificity of 93 p.c., a positive predictive value of 98 p.c., a negative predictive value of 87 p.c., and a Youden's index of 98 p.c....


    101/2523

    Tytuł oryginału: The respriation of mitochondria from human skeletal muscle coupled to ATP synthesis is not impaired in pH 6.45 medium but is depressed at pH 7.8.
    Tytuł polski: Oddychanie mitochondriów mięśnia szkieletowego człowieka skojarzone z syntezą ATP - bez zmian w środowisku o pH 6,45, hamowanie w pH 7,8.
    Autorzy: Popinigis Jerzy, Antosiewicz Jędrzej, Crimi Massimo, Kaczor Jan Jacek, Bargossi Alberto Mario, Mercuri Mario, Gruca Zbigniew, Lenaz Giorgio
    Źródło: Med. Sport. 2002: 18 (1) s.11-24, il., tab., bibliogr. 40 poz., streszcz.
    Sygnatura GBL: 313,155

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Cel pracy: W czasie pierwszych kilku sekund wysiłku fizycznego w wyniku działania enzymu kinazy kreatynowej, wnętrze komórki mięśniowej ulega alkalizacji - wg Conetta nawet do pH 7,8. W wyniku kontynuacji wysiłku i powstawania kwasu mlekowego dochodzi następnie do zakwaszenia cytosolu, a obniżenie pH do wartości 6,45 doprowadza do zatrzymania glikolizy. Celem niniejszej pracy było zbadanie jak zmiany pH środowiska z wartości 7,0 do 6,45 i z 7,0 do 7,8 będą wpływały na aktywność oddechową mitochondriów otrzymanych z mięśnia szkieletowego człowieka. Materiały i metody: mitochondria izolowano z mięśni szkieletowych pochodzących z zabiegów operacyjnych typu amputacji dokonywanych ze wskazań lekarskich. Pomiaru zużycia tlenu przez mitochondria dokonywano za pomocą klasycznej elektrody tlenowej Clarka. Stosowano środowiska o pH 7,0 lub 6,45, lub 7,8. Substratami były: glutaminian z jabłczanem, pirogronian z jabłczanem oraz mleczan z NAD. Wyniki: w przypadku oddychania wysoko sprzężonego z syntezą ATP krótka ekspozycja mitochondriów do warunków pH 6.45 nei zmieniała ich aktywności oddechowej. Wyjątkiem było utlenianie mlecznu z NAD, które ulegało zahamowaniu. Mitochondria, których oddychanie było słabiej skojarzone z syntezą ATP, nieznacznie zmniejszały zużycie tlenu w pH 6.45. Natomiast 50 proc. hamowania obserwowano w pH 6.45 w mitochondriach z uszkodzoną strukturą. Hamowanie oddychania obserwowano w pH 7.8, nawet w mitochondriach dobrze skojarzonych. Obniżenie pH z 7,0 ...

    Streszczenie angielskie: Aim of the study: during the first seconds of exercise due to creatine kinase reaction the interior of the muscle cell becomes alkaline, and according to Connett reaches pH 7.8 When exercise continues, the cytosol - due to formation of lactic acid - becomes acidic and glycolysis stops when pH reaches value of 6.45. The aim of our research was to investigate how changes of the pH of the medium from 7,0 to 6.45 or from 7.0 to 7.8 would affect the respiratory activity of mitochondria from human skeletal muscle. Materials and methods: mitochondria were isolated from post amputationem muscles of patients undergoing surgery. Oxygen uptake was measured with the classical Clark type oxygen electorde in pH 7.0, pH 6.45 and pH 7.8 media. Glutamate + malate, or pyruvate + malate, or NAD + lactate were used as respiratory substrates. Results: The respiration that was tightly coupled to ATP synthesis was found not impaired by short exposure to medium with pH 6.45. Exception was lactate (+ NAD) oxidation, which was arrested at this pH. Slight inhibition of respiration at pH 6.45 was noted in loose-coupled mitochondria, but almost 50 p.c. inhibition was seen at pH 6.45 in disrupted mitochondria. The coupled respiration of mitochondria was found inhibited at pH 7.8. Lowering of pH from 7.0 to 6.0 did not affect the activity of complex IV of respiratory chain, but complex I was under these conditions inhibited 39 p.c. and complex III 53 p.c. Activity of complex IV was inhibited 36 ...


    102/2523

    Tytuł oryginału: The search for optimal treatment in relapsed and refractory acute myeloid leukemia.
    Autorzy: Robak Tadeusz, Wrzesień-Kuś Agata
    Źródło: Leuk. Lymphoma 2002: 43 (2) s.281-291, tab., bibliogr. 116 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Despite the significant progress in the treatment of AML during the last 5-10 years, 20-40 p.c. of patients still do not achieve remission with standard induction therapy. In addition, 50-70 p.c. of patients in CR are likely to relapse. A major limitation of successful AML therapy is intrinsic or acquired drug resistance. Several pharmacological inhibitors of mechanisms inducing chemoresistance in leukemic cells have been investigated. New cytotoxic drugs, agents with novel mechanisms of action, and new treatment strategies are currently being investigated. The management of refractory or relapsed AML patients is reviewed in this study.


    103/2523

    Tytuł oryginału: In vitro drug resistance profiles of adult acute lymphoblastic leukemia: possible explanation for difference in outcome to similar therapeutic regimens.
    Autorzy: Styczyński Jan, Wysocki Mariusz
    Źródło: Leuk. Lymphoma 2002: 43 (2) s.301-307, il., tab., bibliogr. 79 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • pediatria
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Age has important prognostic impact in acute lymphoblastic leukemia (ALL). Adults with ALL have a worse prognosis compared to children. This may be due to different, unfavorable biology, poor treatment tolerance, drug resistance, higher expression of drug resistance related proteins. The lymphoblasts from adult ALL show an increased in vitro resistance to cytotoxic drugs, including prednisolone, dexamethasone, cytosine arabinoside, daunorubicin, L-asparaginase and methotrexate. Glucocorticoid resistance may be a fundamental difference between children, adolescents and adults with ALL, which may underlie different biological aspects and also explain the difference in prognosis. It seems that in vitro resistance to prednisolone with respect to the age might be a continuous variable in ALL patients, except infants. The greater the age, the higher the in vitro resistance to prednisolone. This may be due to induction of various defense mechanisms, such as an activation of P-glycoprotien, which develops throughout the life and protect the human against xenobiotics. Among a number of various drug resistance mechanisms, only several weak differences between adults and children with ALL have been reported including higher P-glycoprotein expression, lower methotrexate polyglutamate accumulation and possibly more often p53 gene mutations in adults. Intrinsic resistance, induction of drug resistance proteins expression during chemotherapy and co-existence of various mechanisms are common phenomena in adult ALL. It seems that age itself, more than drug resitance profile, reflects factors which have direct effect on chemotherapy response in adult ALL.


    104/2523

    Tytuł oryginału: G-CSF administered in time-sequenced setting during remission induction and consolidation therapy of adult acute lymphoblastic leukemia has beneficial influence on early recovery and possibly improves long-term outcome: a randomized multicenter study.
    Autorzy: Hołowiecki Jerzy, Giebel Sebastian, Krzemień Sławomira, Krawczyk-Kuliś Małgorzata, Jagoda Krystyna, Kopera Małgorzata, Hołowiecka Beata, Grosicki Sebastian, Hellmann Andrzej, Dmoszyńska Anna, Paluszewska Monika, Robak Tadeusz, Konopka Lech, Maj Stanisław, Wojnar Jerzy, Wojciechowska Maria, Skotnicki Aleksander, Baran Wojciech, Cioch Maria
    Źródło: Leuk. Lymphoma 2002: 43 (2) s.315-325, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Sixty-four untreated adult acute lymphoblastic leukemia (ALL) patients were randomized to receive chemotherapy alone, n = 31 or chemotherapy and granulocyte colony stimulating factor (G-CSF), n = 33. During induction patients received G-CSF for 5 days between four weekly Epirubicin + Vcradministrations, starting 36 h after each application and finishing 48 h before the next one with the intention to possibly generate a cell cycle dependent protection of normal hematopoietic progenitors and to stimulate granulopoiesis. The complete remission (CR) rate equaled 94 p.c. in the G-CSF group and 87 p.c in controls. Patients who received G-CSF, if compared to the controls, had shorter granulocytopenia during induction and consolidation, displayed a lower infection rate, completed the induction-consolidation quicker and stayed shorter in hospital during induction, p 0.001 - 0.04. Follow-up at 2 years revealed a rather higher probability of survival (59 vs. 27 p.c., p = 0.04) and a lower relapse rate (32 vs. 60 p.c.) in G-CSF arm than in controls. The beneficial influence of G-CSF administered in time-sequenced fashion on survival needs further confirmation.


    105/2523

    Tytuł oryginału: Fludaraibine therapy in Waldenstr”m's macroglobulinemia patients treated previously with 2-chlorodeoxyadenosine.
    Autorzy: Lewandowski Krzysztof, Halaburda Kazimierz, Hellmann Andrzej
    Źródło: Leuk. Lymphoma 2002: 43 (2) s.361-363, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Six patients with Waldenstr”m's Macroglobulinemia (WM) resistant to previous 2-chlorodeoxyadenosine (2-CdA) therapy were treated with fludarabine. Both initial and subsequent therapy was administered according to the most widely used protocols. The median number of 2-CdA cycles given to the patients was 3.7 (range 2-5), while fludarabine was 1.7 (range 1-2). As a result partial remission was achieved in two patients and stabilization of the disease in the remaining four in spite of the inadequate response or progressive disease after 2-CdA therapy. Median monoclonal IgM concentration fell from 29.4 (range 11.6-37.1) to 16.4 g/l (range 3.8-29.1). At the same time hemoglobin concentration increased from median 114 (range 89-129) to 122 g/l (range 97-133). Side effects consisted of neutropenia (three patients) and thrombocytopenia (two patients). Two patients are alive with progression of the disease noted after 12 and 21 months of observation. One patients died as the result of cardiac disease, two other died of infection 5 and 16 months after cessation of therapy in the course of disease progression. The remaining patient was lost to follow-up after 10 months of observation with continuous stabilization. Our observation suggest that in WM patients resistant to 2-CdA, stabilization of the disease or even remission can be obtained with fludarabine.


    106/2523

    Tytuł oryginału: Production of proangiogenic cytokines during thalidomide treatment of multiple myeloma.
    Autorzy: Dmoszyńska Anna, Bojarska-Junak Agnieszka, Domański Damian, Roliński Jacek, Hus Marek, Soroka-Wojtaszko Maria
    Źródło: Leuk. Lymphoma 2002: 43 (2) s.401-406, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Recently a growing number of studies have suggested the efficacy of thalidomide (THAL) in the treatment of relapsed or resistant multiple myeloma. Some of these studies indicate that the thalidomide antimyeloma effect is associated with decreased vessel density. Here we first present our experience with THAL treatment and then focus on the determination of the role of proangiogenic cytokines during THAL therapy. Thirty relapsing or resistant multiple myeloma (MM) patients were treated with THAL at a median dose of 400 mg/daily. Eighteen responded to THAL therapy and 12 were resistant or intolerant to THAL. We determined the plasma level of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) as the main biological parameters associated with tumour angiogenesis. In addition I1-6 and TNFŕ levels were also assayed. Assessment of peripheral blood (PB) and bone marrow (BM) cytokine levels were done before and during THAL treatment at weeks 4 and 8 of therapy. In the responder group VEGF, bFGF I1-6 and TNFŕ concentrations were significantly decreased after four weeks of therapy both in PB and BM. In the non-responder group no significant changes in bFGF and VEGF levels were observed. However, a significant increase in IL-6 and TNF concentrations was evident. We conclude that the significant decrease of VEGF, bFGF, I1-6 and TNFŕ concentrations reflected response to THAL therapy. Also it seems that VEGF is a better marker of response to treatment than bFGF.


    107/2523

    Tytuł oryginału: Influence of the alpha-1-adrenergic receptor blocker doxazosin on exercise-induced hyperkalemia in hemodialysis patients.
    Autorzy: Nowicki Michał, Waluś Tomasz, Kokot Franciszek
    Źródło: Kidney Blood Press. Res. 2002: 25 (1) s.55-60, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,314

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background/Aim: Hyperkalemic responses to both physical exercise and ŕ-adreenergic stimulation are enhanced in patients with terminal renal failure. ŕ-Adrenergic blockade was found to protect against hyperkalemia during vigorous exercise in healthy men. The aim of the study was to examine the effects of the ŕ-adrenergic blocker doxazosin on exercise-induced hyperkalemia in hemodialysis patients. Methods: In a randomized, placebo-controlled, crossover design study, 15 anuric, chronic hemodialysis patietns were included. Doxazosin or placebo was given in a random order for 4 days before exercise. At the end of each phase of the study, a 30-min treadmill exercise test with a constant workload of 2 metabolic equivalents was performed followed by a 30-min recovery period. Results: The patients achieved 64 ń 3 and 62 ń 3 p.c. of maximal heart rate during the exercise test on doxazosin and placebo, respectively. The baseline plasma concentration of potassium was similar both on active treatment and on placebo (5.1 ń 0.2 mmol/l on doxazosin and 4.9 ń 0.1 mmol/l on placebo). The serum potassium concentration increased significantly and to a similar extent during the tests. The mean rates of potassium increment during exercise were 8.4 ń 1.5 ćmol/l/min on doxazosin and 6.9 ń 1.3 ćmol/l/min on placebo. During the recovery period, the serum potassium concentration significantly decreased in both arms of the study. There were no significant changes in plasma sodium, calcium, and phosphate levels during the tests. Hydrogen ion concentration in blood, serum insulin and glucose, and plasma aldosterone and renin activity were similar before the exercise tests...


    108/2523

    Tytuł oryginału: Characterization of histamine H2-like receptors in duck cerebral cortical membranes by [3H]tiotidine binding.
    Autorzy: Zawilska Jolanta, Zalewska-Kaszubska Jadwiga, Przybysz Marzena, Nowak Jerzy Z.
    Źródło: Neurosci. Lett. 2002: 319 (3) s.149-152, il., bibliogr. 18 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • ptaki
  • in vitro

    Streszczenie angielskie: A selective (according to mammalian criteria) histamine (HA) H2-receptor radioligand ([3H]TIOT) was used to characterize HA receptors in duck cerebral cortex by an in vitro binding technique. The specific binding of [3H]TIOT to duck cerebral cortical membranes was found to be rapid, stable, saturable, reversible, and of high affinity. Saturation analysis resulted in a linear Scatchard plot suggesting binding to a single class of receptor binding sites with high affinity (Kd = 19.5 nM) and high capacity (Bmax - 356 fmol/mg protein). Competition studies showed the following relative rank order of potency of various HA receptor ligands to inhibit the [3H]TIOT binding: antagonists, tiotidine rantidine izolantidine ň cimetidine mepyramine thioperamide; agonists, HA ň 4-methylHA 2-methylHA dimaprit Rŕ-methylIHA. The biphasic nature of the displacement curve for HA and the effect of 5'-guanylimidodiphosphate indicate with [3H]TIOT represent either avian-specific H2-like HA receptors or a novel subtype of HA receptors, coupled to a signalling athway other than the adenylyl cyclase/cyclic adenosine monophosphate one.


    109/2523

    Tytuł oryginału: New stereocontrolled synthesis and biological evaluation of 5-(1'-Hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as potential cytotoxic agents.
    Autorzy: Janecki Tomasz, Błaszczyk Edyta, Studzian Kazimierz, Różalski Marek, Krajewska Urszula, Janecka Anna
    Źródło: J. Med. Chem. 2002: 45 (5) s.1142-1145, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 312,133

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: A series of 3-methylidenetetrahydro-2-furanones 7 bearing various hydroxyalkyl substituents in position 5 were synthesized using novel diastereo- and enantioselective methodology. In vitro cytotoxicity data demonstrated that all prepared compounds were active against L-1210 and HL-60 tissue culture cells with 7e being the most potent (IC50 = 6.9 ćM). Also an increase in activity with an increase in lipophilicity of the substituents in the order H , alkyl phenyl was observed.


    110/2523

    Tytuł oryginału: Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma.
    Autorzy: Kamiya Yuji, Puzianowska-Kuźnicka Monika, McPhie Peter, Nauman Janusz, Cheng Sheue-yann, Nauman Alicja
    Źródło: Carcinogenesis 2002: 23 (1) s.25-33, il., tab., bibliogr. 59 poz.
    Sygnatura GBL: 312,779

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Thyroid hormone (T3) regulates proliferation and differentiation of cells, via its nuclear receptors (TRs). These processes have been shown to be abnormally regulated during carcinogenesis. We have previously found aberrant expression of TRŕ and TRá mRNAs in renal clear cell carcinoma (RCCC), suggesting possible involvement of TRs in the carcinogenesis of RCCC. To understand the molecular actions of TRs in RCCC, cDNAs for TRá1 and TRŕ1 were cloned from 22 RCCC tissues and 20 surrounding normal tissues. Mutations were found in seven TRá1 and three TRŕ1 cDNAs. Two TRá1 cDNAs had a single mutation, while five TRá1 and three TRŕ1 had two or three mutations. Most of the mutations were localized in the hormone-binding domain. Using the TRs prepared by in vitro transcription/translation, we found that these mutations led to a loss of T3 binding activity and/or impairment in binding to thyroid hormone response elements (TREs). Furthermore, nuclear extracts from RCCC tissues also exhibited impairment in binding to TREs. These results indicate that the normal functions of TRs in RCCC tissues were impaired. Together with the aberrant expression patterns, these mutated TRs could contribute to the carcinogenesis of RCCC.


    111/2523

    Tytuł oryginału: Ludwik Hirszfeld as I remember him [1884-1954].
    Autorzy: Skurska Zofia
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.5-8
    Sygnatura GBL: 304,223

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Hirszfeld
  • Ludwik 1844-1954


    112/2523

    Tytuł oryginału: Remembering Professor Ludwik Hirszfeld [1884-1954].
    Autorzy: Benendo-Kapuścińska Bogusława
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.9-11, il.
    Sygnatura GBL: 304,223

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Hirszfeld
  • Ludwik 1884-1954


    113/2523

    Tytuł oryginału: Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal, ... and get ready to face autoimmunity.
    Autorzy: Tirapu Inigo, Mazzolini Guillermo, Rodriguez-Calvillo Mercedes, Arina Ainhoa, Palencia Belen, Gabari Izaskun, Malero Ignacio
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.13-18, bibliogr. 62 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Cellular immune responses can destory cancer cells, achieving the cure of experimental malignancies. An exapanding wealth of knowledge on the molecular basis of how to prime and amplify a T cell response has fueled a number of strategies successful at treating estabilished tumors (rather than merely preventing tumor grafting). The most efficacious approaches operate at different stages, including: 1) priming the immune response using tumor antigen-expressing dendritic cells or tumor cells transfected with genes that render them immunogenic, 2) sustaining and amplifying immunity using agonistic monoclonal antibodies against costimulatory molecules or immune-potentiating cytokines, and 3) eliminating mechanisms that self-regulate the strenght of the immune response, such as inhibitory receptors or regulatory T cells. A rational combination of such approaches holds great hope for cumulative and synergistic effects, but there is also evidence that they can open the flood-gates for unwanted inflammatory reactions. The next decade can be envisioned as the time when the first reproducibly efficacious combination regimes for cancer immunotherapy will become available and videly used in the clinic, as clinicians learn the best strategies and try to harness their potentially damaging effects.


    114/2523

    Tytuł oryginału: Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies.
    Autorzy: Sadowski-Debbing Kenneth, Coy Johannes F., Mier Walter, Hug Hubert, Los Marek
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.19-34, il., tab., bibliogr. 113 poz.
    Sygnatura GBL: 304,223

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is carefully controlled by a philogenetically conserved death program, which is indispensable for the homeostasis and development of higher organisms. Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. In vitro studies have demonstrated the requirement of caspase activity for both the triggering phase as well as the execution of apoptosis, thus providing a molecular base for the fine-tuning of this process by pharmacological agents. The precise roles of the individual caspases in vivo and their functional relation to each other have been best demonstrated in genitically modified animals. The generation of single caspase-deficient mice have confirmed most of the data obtained in vitro and exposed some new aspects previously undetected in teh cell culture system. Interestingly, inactivation of many caspases revealed not only their expected participation in apoptotic as well as in the maturation of cytokines, but also provided hints about the role of at least some caspases in cell differentiation and stimulatory responses. In this review we will discuss what these studies have unveiled about the role of individual caspases in development, apoptosis, and inflammation, with particular focus on their role beyond the apoptotic process.


    115/2523

    Tytuł oryginału: The role of the innate and adaptive immune responses in Acanthamoeba keratitis.
    Autorzy: Niederkorn Jerry Y.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.53-59, bibliogr. 49 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • okulistyka
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Infections of the corneal surface are an important cause of blindness. Protozoal, viral, bacterial, and helminthic infections of the cornea account for up to 9 milion cases of corneal blindness. Free-living amoebae of the genus Acanthamoeba produce a progressive infection of the cornea called Acanthamoeba keratitis. Disease is usually transmitted by Acanthamoeba trophozoites bound to soft contact lenses. Infection of the cornea is initiated when the parasite binds to the corneal epithelial surface. Recrudescence can occur and suggests that the adaptive immune response is not aroused by corneal Acanthamoeba infections. Systemic immunization with Acanthamoeba antigens elicits robust Th1 cell-mediated immunity and serum IgG antibody, yet fails to prevent the development of Acanthamoeba keratitis. However, immunization via mucosal surfaces induces anti-Acanthamoeba IgA antibodies in the tears and provides solid protection against the development of Acanthamoeba keratitis. Unlike other immune effector mechanisms that rely on cytolysis, inflammation, release of toxic molecules, or the induction of host cell death, the adaptive immune apparatus prevents Acanthamoeba infections of the cornea by simply preventing the attachment of the parasite to the epithelial surface. The beauty of this mechanisms lies in its exquisite simplicity and efficacy.


    116/2523

    Tytuł oryginału: Thermal glycation of proteins by D-glucose and D-fructose.
    Autorzy: Kańska Urszula, Boratyński Janusz
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.61-66, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 304,223

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The dry thermal glycation method was used to conjugate D-glucose and D-fructose with bovine serum albumin. Reactions were conducted at 50-104řC for 30 min. Depending on temperature, different levels of substitution were achieved. In the case of D-glucose, average substitution levels of up to 53 mol glucose/mol bovine serum albumin were obtained. D-fructose turned out to be less reactive than D-glucose. The pH of the reaction mixture was also found to affect the efficacy of the glycation reaction. The levels of substitution were estimated using matrix-assisted laser desorption/ionisation time -of-flight mass spectrometry and SDS-polyacrylamide gel electrophoresis. Glycated molecules, and a process of glycation itself are implicated in diabetes complications. Hypothetically bovine spongiform encephelopathy (BSE) was also derived from glycation.


    117/2523

    Tytuł oryginału: Glycoforms of six serum glycoproteins in a patient with congenital disorder of glycosylation type I.
    Autorzy: Ferens-Sieczkowska Mirosława, Zwierz Krzysztof, Midro Alina, Kątnik-Prastowska Iwona
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.67-73, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć żeńska

    Streszczenie angielskie: In this paper the occurrence and relative content of defectively glycosylated serum glycoforms in transferrin (Tf), ŕ1-acid glycoprotein (AGP), haptoglobin (Hp), ŕ1-antitripsin (ŕ1-AT), ŕ2-macroglobulin (ŕ2-MG) and ceruloplasmin (Cpl) in the serum of a patient with congenital disorder of glycosylation type I are reported. Blood samples were taken when the patient was 14 years old and then after a one-year interval. The patterns of glycoforms in both samples were compared. In 4 out of 6 examined glycoproteins, glycoforms lacking one and two oligosaccharide chains occurred. "Underglycosylated" glycoforms of ŕ2-MG and Cpl were not clearly detectable. Tf was shown to be affected with this defect to a higher extent than other glycoproteins, containing only 30 p.c. properly glycosylated molecules and also as much as 30 p.c. of the molecules lacking two glycan units. In Hp and ŕ1-AT the proportions of properly and defectively glycosylated forms were similar. This properly glycosylated form comprised 47 p.c. of the Hp and 51-55 p.c. of the ŕ1-AT molecules. As in AGP and Tf, about 30 p.c. the of molecules lacked one glycan unit. Twenty-one percent of the Hp molecules were devoid of two glycans, and this amount slightly increased in the course of the year. In ŕ1-AT, 19 and 17 p.c. of the molecules lacked two glycans in both samples, respectively. Only in AGP we did find a substantial difference between the two blood samples. In the course of the year, the amount of the form lacking 2-chains decreases from 12 to 3 p.c., resulting in a simultaneous icrease in the forms lacking...


    118/2523

    Tytuł oryginału: Comparison of leukocyte populations from bronchoalveolar lavage and induced sputum in the evaluation of cellular composition and nitric oxide production in patients with bronchial asthma.
    Autorzy: Bieńkowska-Haba Małgorzata, Cembrzyńska-Nowak Monika, Liebhart Jerzy, Dobek Rafał, Liebhart Ewa, Siemieniec Iwona, Panaszek Bernard, Obojski Andrzej, Małolepszy Józef
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.75-82, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Bronchoalveolar lavage (BAL) or induced sputum (IS) techniques may provide lukocytes for the evaluation of airway inflammatory response in bronchial asthma. The aim of the present study was to compare features of leukocyte populations obtained by the two diffrent methods regarding the cell types and their activity in patients with bronchial asthma. The nitric oxide (NO) level released from the cells was measured as a marker of their activity. Pulmonary leukocytes were obtained from the BAL and IS of 11 asthmatic patients in stable condition at the time of the study. The BAL and IS leukocyte populations varied in cell count and NO production. Macrophages were the predominant leukocyte population in BAL (median (ME) = 83.0 p.c., range 67.9 - 88.4 p.c.), whereas sputum sediments were found to consist mainly of neutrophils (Me = 55.7 p.c., range 29.0 - 64.9 p.c.). The IS leukocytes released much more NO (p = 0.0022) than the BAL leukocytes released much more NO (p=0.0022) than the BAL leukocytes. In spite of these quantitative differences, a similar pattern of NO production was observed in BAL and in IS cells. Both BAL and IS leukocyte populations producted almost the same amounts of NO before and after lipopolysaccharide stimulation (p=0.9063, p= 0.4801, respectively). Furthermore, a slight positive correlation Spearman's rank (Rs)=0.5578, p=0.0594) was noticed between the neutrophil percentages and NO levels produced by BAL cells, whereas in IS a statistically significant correlation between the percentage of neutrophils and the levels of NO (Rs=0.6643, p=0.0184) was observed...


    119/2523

    Tytuł oryginału: The adipose tissue - a novel endocrine organ of interest to the nephrologist.
    Autorzy: Więcek Andrzej, Kokot Franciszek, Chudek Jerzy, Adamczak Marcin
    Źródło: Nephrol. Dial. Transplant. 2002: 17 (2) s.191-195, il., bibliogr. 39 poz.
    Sygnatura GBL: 312,872

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • nefrologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    120/2523

    Tytuł oryginału: Efficacy of the new long-acting formulation of lanreotide (Lanreotide Autogel) in the management of acromegaly.
    Autorzy: Caron Ph., Beckers A., Cullen D. R., Goth M. I., Gutt B., Laurberg P., Pico A. M., Valimaki M., Zgliczyński W.
    Źródło: J. Clin. Endocrinol. Metab. 2002: 87 (1) s.99-104, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 310,620

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this study was to evaluate the efficacy and safety of this new ong-acting formulation in a large population of acromegalic patients previously responsive to lanreotide 30 mg, im (substained release microparticle formulation). Lanreotide Autogel was administered by deep sc injection every 28 d to 107 patients (54 males and 53 females; mean age, 54 ń 1.2 yr). All patients had been treated with lanreotide (30 mg) for at least 3 months before study entry and had a mean GH level less than 10 ng/ml after at least 4 subsequent im injections every 14 d (48 p.c.), 10 d (32 p.c.), or 7 d (20 p.c.). Treatment was switched from lanreotide 30 mg injected every 14, 10, or 7 d to 60, 90, or 120 mg lanreotide Autogel, respectively, every 28 d. After three fixed dose injections of lanreotide Autogel, mean lanreotide levels were similar to those obtained at steady state with lanreotide 30 mg. During lanreotide Autogel treatment, the control of acromegalic symptoms was comparable with that previoulsy achived during lanreotide 30 mg treatment. After 3 injections of lanreotide Autogel, mean GH (2.87 ń 0.22 ng/ml) and IGF-I (317 ń 15 ng/ml) values were comparable with those recorded at the end of lanreotide 30 mg treatment (GH, 2.82 ń 0.19 ng/ml; IGF-I, 323 ń 16 ng/ml). GH levels below 2.5 ng/ml and age-/sex-normalized IGF-I were achived in 33 p.c. and 39 p.c. of patients during lanreotide 30 mg and lanreotide Autogel treatment, respectively...


    121/2523

    Tytuł oryginału: Surgical view of the treatment of patients with hepatoblastoma. Results from the First Prospective Trial of the International Society of Pediatric Oncology Liver Tumor Study Group (SIOPEL-1).
    Autorzy: Schnater J. Marco, Aronson Dani‰l C., Plaschkes Jack, Perilongo Giorgio, Brown Julia, Otte Jean-Bernard, Brugieres Laurences, Czauderna Piotr, MacKinlay Gordon, Vos Anton
    Źródło: Cancer 2002: 94 (4) s.1111-1120, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 311,015

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background. Surgical resection is the cornerstone of treatment for patients with hepatoblastoma (HB). The Society of Pediatric Oncology Liver Tumor Study Group launched its first prospective trial (SIOPEL-1) with the intention to treat all patients with preoperative chemotherapy and delayed surgical resection. The objective of this article was to assess the assumed surgical advantages of primary chemotherapy. Methods. Between 1990 and 1994, 154 patients age 16 years with HB were registered on SIOPEL-1. The pretreatment extent of disease was assessed, and, after undergoing biopsy, patients were treated with cisplatin 80 mg/mý intravenously over 24 hours and doxorubicin 60 mg/mý intravenously over 48 hours by continuous infusion (PLADO). Generally, tumors were resected after four of a total of six courses of PLADO. Results. One hundred twenty eight patients underwent surgical resection (13 patients underwent primary surgery, and 115 patients underwent delayed surgery after PLADO). A pretreatment surgical biopsy was performed in 96 of 128 patients (75 p.c.). Biopsy complications occurred in 7 of 96 patients (7 p.c.). Twenty-two patients showed pulmonary metastases at the time of diagnosis, and 7 patients underwent thoracotomy. Operative morbidity and mortality were 18 p.c. and 5 p.c., respectively. Complete macroscopic surgical resection was achieved in 106 patients (92 p.c.), including 6 patients who underwent orthotopic liver transplantation. The actuarial 5-year event free survival (EFS) rate for all 154 patients in the study was 66 p.c., and the overall survival (OS) rate was (75 p.c.)...


    122/2523

    Tytuł oryginału: Elevated soluble intercellular adhesion molecule-1 levels in obesity: relationship to insulin resistance and tumor necrosis factor-ŕ system activity.
    Autorzy: Strączkowski Marek, Lewczuk Piotr, Dzienis-Strączkowska Stella, Kowalska Irina, Stępień Agnieszka, Kinalska Ida
    Źródło: Metabolism 2002: 51 (1) s.75-78, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 303,583

    Hasła klasyfikacyjne GBL:
  • immunologia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Intercellular adhesion molecule-1 (ICAM-1) is 1 of the possible factors linking obesity and diabetes with cardiovascular disease, however, the mechanism of the increase in ICAM-1 concentration in obesity remains unclear. Therefore, the aim of the present study was to assess plasma soluble ICAM-1 (sICAM-1) levels on obese subjects with normal glucose tolerance and to evaluate whether those levels may be related to insulin resistance and tumor necrosis factor-ŕ (TNFŕ) system activity. The study was performed in 8 lean and 15 obese subjects. Anthropometric and biochemical parameters were measured, and insulin sensitivity was evaluated using the euglycemic hyperinsulinemic clamp technique (insulin infusion, 50 mU x kg**-1 x h**-1). Obese subjects were markedly more hyperinsulinemic and insulin resistant and had higher plasma soluble TNF receptor 2 (sTNFR2) and sICAM-1 levels. sICAM-1 was related positively to body mass index (BMI), waist-to-hip ratio (WHR), percent of body fat, glycated hemoglobin (HbA1c), plasma insulin and triglycerides (TG), TNFŕ, and sTNFR2 and negatively to insulin sensitivity. Multiple regression analysis showed that only sTNFR2 and insulin sensitivity were independent predictors of sICAM-1 concentrations and were responsible for 66 p.c. of sICAM-1 variability. We conclude that an increase in plasma sICAM-1 concentration in obesity is related to TNFŕ system activation and insulin resistance.


    123/2523

    Tytuł oryginału: Enhanced T cells interactions with extracellular matrix proteins in infertile women with endometriosis.
    Autorzy: Jerzak Małgorzata, Baranowski Włodzimierz, Rechberger Tomasz, Górski Andrzej
    Źródło: Immunol. Lett. 2002: 81 (1) s.65-70, il., tab., bibliogr. 53 poz.
    Sygnatura GBL: 312,663

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Essential features of endometriosis involve interactions with extracellular matrix (ECM). Recent data emphasize the important role of ECM proteins in the regulation of T cell function. The aim of this study was to determine activated T cell adhesion to ECM proteins in infertile women with endometriosis. Nine women with endometriosis diagnosed by laparoscopy according to the Revised American Fertility Society classification and ten normal healthy women with a previous successful pregnancy outcome were studied. We investigated phorbol acetate myristate (PMA) or phytohemaglutinin (PHA) activated peripheral blood T cell adhesion to the following proteins of ECM: collagen IV (C-IV), elastin (E) and fibronectin (Fn). In addition, CD4, CD8, CD29, CD45RO exspression on peripheral CD3+ T cells were studied using flow cytometry. We determine that PHA-activated T cell adhesion to C-IV and Fn are significantly higher in infertile women with endometriosis when compared to normal healthy women (P 0.05). No significant differences were noted in T cell's surface antigens expression between study groups. Our data suggest the existence of disturbed T cell-ECM interactions in infertile women with endometriosis. Further studies are needed to determine the role of these abnormalities in the pathogenesis of endometriosis.


    124/2523

    Tytuł oryginału: Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris.
    Autorzy: Cisło Maria, Hałasa Jolanta, Wąsik Feliks, Nockowski Piotr, Prussak Magdalena, Mańczak Maria, Kuśnierczyk Piotr
    Źródło: Immunol. Lett. 2002: 80 (3) s.145-149, tab., bibliogr. 58 poz.
    Sygnatura GBL: 312,663

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Psoriasis vulgaris is a multifactorial disease; the strongest association was established with the HLA complex. The actual disease-predisposing gene(s) has not been identified yet, but several genes from this region were examined in addition to HLA-C and -B. However, HLA-linked complement component polymorphic genes were not extensively studied. Therefore, we typed 67 psoriatic patients for alleles of the HLA-linked complement components BF, C4A and C4B. Alleles of C3, encoded on another chromosome, were established in parallel as a negative control. Frequencies in patients were compared with thise in unrelated healthy controls, 100 individuals for C4A and C4B, 890 for BF and 4719 for C3. We found no association of BF alleles with disease, similarly to C3. Among C4 alleles, C4B*3 was present in 13,4 p.c. of patients as compared with 1 p.c. of controls (OR, 15.36; 95 p.c. CI, 1.897 - 124.42; P = 0.0009), and C4A*6 was present in 19.4 p.c. of patients versus 7 p.c. of controls (OR, 3.20; 95 p.c. CI, 1.202 - 8.508; P = 0.0155). The high frequency of C4B*3 in psoriatics has not been described so far. These results suggest a contribution of C4 genes themselves or a closely linked gene to the susceptibility to psoriasis.


    125/2523

    Tytuł oryginału: Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart.
    Autorzy: Kurzelewski Michał, Czarnowska Elżbieta, Beręsewicz Andrzej
    Źródło: Eur. J. Pharmacol. 2002: 434 (1/2) s.95-107, il., tab., bibliogr. s. 105-107
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie

    Streszczenie angielskie: This study addressed the hypothesis that endothelin promotes neutrophil accumulation in ischemic/reperfused myocardium, not only via its direct effect on neutrophils, but also because it mediates post-ischemic endothelial injury. Langendorff-perfussed guinea-pig hearts were subjected to 30 min ischemia/35 min reperfusion, and infusion of neutrophils between 15 and 25 min of reperfusion. The infusion of the endothelin ETA/ETB receptor antagonist, tezosentan, the endothelin ETA receptor antagonist, BQ 123 [cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-], and superoxide dismutase was terminated at reperfusions, 5 min before the start of the neutrophil infusion, to avoid the contact of the drugs with neutrophils. Coronary flow responses to acetylcholine and nitroprusside were used as measures of endothelium-dependent and -independent vascular function, respectively. Neutrophil adhesion and endothelium glycocalyx ultrastructure were assessed in histological preparations. Ischemia/reperfusion resulted in a 54 p.c.-impaired acetylcholine response, endothelium glycocalyx disruption, and enhanced neutrophil adhesion (21.6 p.c. of microvessels contained neutrophils vs. 2.6 p.c. in sham group), the latter prevented by a selectin blocker, sulfatide, 20 ćg/ml. These alterations were completely prevented by 0.5 and 5 nM, but not 0.05 nM, tezosentan, and were greatly attenuated by BQ 123, 1 and 10 nM. The glycocalyx-protective effect of these interventions preceded their effect on neutrophil adhesion. Superoxide dismutase, 150 IU/ml, reported before by us to protect post-ischemic endothelium glycocalyx, here prevented the post-ischemic endothelial dysfunction and neutrophil adhesion...


    126/2523

    Tytuł oryginału: Successful use of activated recombinant factor VII to control bleeding abnormalities in a patient with a left ventricular assist device.
    Autorzy: Ziętkiewicz Mirosław, Garlicki Mirosław, Domagała Jerzy, Wierzbicki Karol, Drwiła Rafał, Pfitzner Roman, Dziatkowiak Antoni
    Źródło: J. Thorac. Cardiovasc. Surg. 2002: 123 (2) s.384-385, bibliogr. 5 poz.
    Sygnatura GBL: 310,230

    Hasła klasyfikacyjne GBL:
  • hematologia
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • komunikat
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska


    127/2523

    Tytuł oryginału: N-acetyltransferase 2 polymorphism in sporadic Parkinson's disease in a Polish population.
    Autorzy: Białecka Monika, Gawrońska-Szklarz Barbara, Droździk Marek, Honczarenko Krystyna, Stankiewicz Jan
    Źródło: Eur. J. Clin. Pharmacol. 2002: 57 (12) s.857-862, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 312,148

    Hasła klasyfikacyjne GBL:
  • genetyka
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Objective: A genetic background of Parkinson's disease has been suggested, including genes implicated in xenobiotic metabolism. So far, many candidate genes responsible for the occurrence of the disease have been enumerated. This study was carried out to determine the presence of N-acetyltransferase 2 polymorphism in Parkinson's disease patients in a Polish population. Methods: Fifty-four patients with diagnosed sporadic Parkinson's disease and 81 healthy individuals were enrolled into the study. The N-acetyltransferase 2 alleles (*4, *5, *6 and *7) were identified using polymerase chain reaction-restriction fragment length polymorphism methods with DNA extracted from peripheral blood. Results: A preponderance of slow acetylators in patients with Parkinson's disease was demonstrated. Among 54 subjects with parkinsonism, 64.8 p.c. were homozygous for two mutated alleles responsible for the slow-acetylator phenotype. In the control group, a predominance of fast acetylators was noted. Subjects homozygous and heterozygous with genotypes determining fast acetylation constituting 53 p.c. of subjects, whereas 47 p.c. were slow acetylators. Comparison of the two groups of the study, i.e. Parkinson's disease and healthy individuals, revealed a statistically significant predominance of slow acetylators in Parkinson's disease patients (P 0.05). The risk of Parkinson's disease development was more than two times greater in slow acetylators than healthy subjects. The frequency of point mutations was similar both in patients with Parkinson's disease and the healthy cotrols. Conclusion: Slow-acetylation genotype may be an important factor of individual susceptibility to Parkinson's disease.


    128/2523

    Tytuł oryginału: Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in different histological variants of rheumatoid synovitis.
    Autorzy: Klimiuk P. A., Sierakowski S[tanisław], Latosiewicz R[obert], Cylwik B[ohdan], Skowroński J[an], Chwiecko J.
    Źródło: Rheumatology 2002: 41 (1) s.78-87, il., tab., bibliogr. 50 poz.
    Sygnatura GBL: 303,271

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective. Rheumatoid synovitis is characterized by an invasive and tissue-destructive infiltrate of lymphocytes, macrophages and synoviocytes. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) produced by these cells are important in the remodelling of the articular tissue in rheumatoid arthritis (RA). The aim of this study was to explore whether the serum concentrations of MMPs and their inhibitors were correlated with the histological appearance of the disease. Methods. Tissue and serum samples were obtained from 37 patients with clinically active RA and 30 with osteoarthritis (OA). Morphological analysis allowed the division of RA synovial specimens into two distinct types. In 22 samples only diffuse infiltrates of mononuclear cells without further microanatomical organization were found. In 15 specimens we observed lymphocytic conglomerates with germinal centre-like structures. Serum concentrations of interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), gelatinase B (MMP-9), TIMP-1 and TIMP-2 were measured with an ELISA technique. Results. Unique serum profiles of MMPs and TIMPs were identified in each of the two histological types of RA synovitis. The serum concentrations of MMP-1, MMP-3 and MMP-9 were higher in RA patients than in OA patients used as a control group (P 0.001 for all comparisons). These three MMPs dominated in the serum of RA patients with follicular synovitis compared with those diffuse synovitis (P 0.05, P 0.01 and P 0.001 respectively)...


    129/2523

    Tytuł oryginału: GLP-1 as a satiety fctor in children with eating disorders.
    Autorzy: Tomasik P. J., Sztefko K., Malek A.
    Źródło: Horm. Metab. Res. 2002: 34 (2) s.77-80, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 312,226

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć żeńska

    Streszczenie angielskie: GLP-1, with its insulinotropic properties and direct action on satiety center in the brain, may be the main hormone regulating the amount of ingested food. In this study, GLP-1 secretion was investigated in age-matched adolescent girls (14 ń 2 years): 13 with anorexia nervosa (BMI 14.8 ń 1.4 kg/mý), 13 with simple obesity (BMI 33.0 ń 3.3 kg/mý) and 10 healthy girls as a control group (BMI 21.6 ń 0.7 kg/mý). Each girl was subjected to OGTT and standard meal tests after a 12h overnight fast. Blood samples were collected before and 15, 30, 60, and 120 min after the stimulation. The mean fasted GLP-1 levels in simple obesity group (1.6 ń 0.3 pmol/l) and in anorexia nervosa group (1.7 ń 0.3 pmol/l) were significantly lower than those in the control group (2.6 ń 0.4 pmol) (p 0.05) in both cases). The highest peak concentration of GLP-1 was observed in the control group after both stimuli. In each group, the mean integrated GLP-1 outputs were almost twice as high after OGTT than after the test meal (p 0.001 in each case). In our opinion, low secretion of GLP-1 in girls with simple obesity may seriously and negatively influence the course of this disease. On the other hand, low GLP-1 levels in girls with anorexia nervosa are beneficial and promote appetite.


    130/2523

    Tytuł oryginału: Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin.
    Autorzy: Kalinowski Leszek, Dobrucki Lawrence W., Brovkovych Viktor, Maliński Tadeusz
    Źródło: Circulation 2002: 105 (8) s.933-938, il., bibliogr. 17 poz.
    Sygnatura GBL: 311,033

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Although statins preserve endothelial function by reducing serum cholesterol levels, it has been suggested they may also stimulate nitric oxide (NO) synthase in endothelium with concurrent increase in superoxide (O2-) generation, leading to impairment of NO activity. Therefore, measurements of biologically active NO and O2 - in endothelium after exposure to the HMG-CoA reductase inhibitor cerivastatin were undertaken to evaluate its potential effect on NO biological activity. Methods and Results - Highly sensitive electrochemical NO and O2 - microsensors were placed near the surface of a single human umbilical vein endothelial cell, and the kinetics of NO and O2 - release were recorded in vitro. Cerivastatin demonstrated a time-dependent effect on NO release in endothelial cels. The initial release (approximately the first 3 minutes) was concentration-dependent (0.01 to 10 ćmol/L) and was similar to that observed for typical NO synthase agonists calcium ionophore or acetylcholine. Cerivastatin stimulated NO release at a favorable rate and scavenged O2-, which led to the preservation of the active concentration of NO. The sustained effect (after ÷ 6 hours) of cerivastatin on endothelium was associated with an ÷ 35 p.c. increase in NO release as compared with the initial effect. In contrast to the initial effect, the sustained effect of cerivastatin was shown at concenrations ÷ 100-fold lower and was dependent on inhibition of endothelial HMG-CoA reductase. Conclusions - These data provide direct evidence to prove that in the presence of cerivastatin, the NOS system in endothelium operates with high efficiency toward increasing NO activity by activation of NO release and by concurrent inactivation of O2-.


    131/2523

    Tytuł oryginału: Juvenile idiopathic arthritis (JIA) is primarily associated with HLA-DR8 but not DQ4 on the DR8-DQ4 haplotype.
    Autorzy: Smerdel A., Ploski R., Flato B., Musiej-Nowakowska E., Thorsby E., Forre O.
    Źródło: Ann. Rheum. Dis. 2002: 61 (4) s.354-357, tab., bibliogr. 17 poz.
    Sygnatura GBL: 310,264

    Hasła klasyfikacyjne GBL:
  • immunologia
  • reumatologia
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Juvenile idiopathic arthritis (JIA) is strongly associated with the DR8-DQ4 haplotype. The genes encoding DR8 and DQ4 are in strong linkage disequilibrium (LD) and oocur together on the same HLA haplotype in almost all patients and controls. Because of the strong LD it is not clear whether DR8, DQ4, or both, are primarily associated with JIA. Objective: To unveil the primary association of JIA - that is, with DR8 or DQ4. Methods: DRB1, DQA1, and DQB1 alleles of 585 Norwegian and 47 Polish unrelated patients with JIA (categorised as pauciarticular and rheumatoid factor negative polyarticular JIA), and of 3155 Norwegian and 158 Polish unrelated controls, were typed using a polymerase chain reaction or oligonucleotide hybridisation and sequence-specific primers method. Results: Several haplotypes which encoded DR8 (that is, carried DRB1*08) and which did not encode DQ4 (that is, did not carry DQA1*0401) were found. Such haplotypes were found in three Norwegian patients and two controls (p = 0.029). In the Polish population such haplotypes were found among four patients with JIA and two controls (p = 0.025). No haplotypes which carried DQA1*0401 and DQB1*0402 in the absence of DRB1*08 were found, either among patients with JIA (Polish and Norwegian) or among the controls (Polish). Conclusion: On the DR8-DQ4 haplotype the DRB1*08 allele is primarily associated with JIA.


    132/2523

    Tytuł oryginału: Estrogen inhibits systemic T cell expression of TNF-ŕ and recruitment of TNF-ŕ+ T cells and macrophages into the CNS of mice developing experimental encephalomyelitis.
    Autorzy: Ito Atsushi, Buenafe Abigail C., Matejuk Agata, Zamora Alex, Silverman Marc, Dwyer Jami, Vandenbark Arthur A., Offner Halina
    Źródło: Clin. Immunol. 2002: 102 (3) s.275-282, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 305,911

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Estrogen treatment has been found to have suppressive activity in several models of autoimmunity. To investigate the mechanism of 17á-estradiol (E2) suppression of experimental autoimmune encephalomyelitis, we evaluated E2 effects on TNF-ŕ experssion in the central nervous system (CNS) and spleen of C57BL/6 mice immunized with MOG 35-55/CFA. Kinetic analysis demonstrated that E2 treatment drastically decreased the recruitment of total inflammatory cells as well as TNF-ŕ+ macrophages and T cell into the CNS at disease onset. In contrast, E2 had only moderate effects on the erlatively high constitutive TNF-ŕ expression by resident CNS microglial cells. E2 treatment also had profound inhibitory effects on expression of TNF-ŕ by splenic CD4+ T cells, including those responsive to MOG 35-55 peptide. We propose that the mechanism of E2 protection may involve both systemic inhibition of TNF-ŕ expression and local (CNS) ercruitment of inflammatory cels, with modest effects on TNF-ŕ expression by resident CNS microglial cells.


    133/2523

    Tytuł oryginału: Extent of, and factors associated with, delay to hospital presentation in patients with acute coronary disease (the GRACE registry).
    Autorzy: Goldberg Robert J., Steg Philippe Gabriel, Sadiq Immad, Granger Christopher B., Jackson Elizabeth A., Budaj Andrzej, Brieger David, Avezum Alvaro, Goodman Shaun
    Źródło: Am. J. Cardiol. 2002: 89 (7) s.791-796, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 304,619

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Our primary study aim was to examine extent of, and factors associated with, delay in seeking medical care in a large multinational registry of patients with acute myocardial infarction (AMI) and unstable angina pectoris. A secondary goal was to examine the relation between duration of prehospital delay and receipt and timing of coronary reperfusion strategies. Investigators from 14 countries are participating in the Global Registry of Acute Coronary Events (GRACE) project. The study sample consisted of 3,693 patients with ST-segment elevation AMI, 2,935 with non-ST-segment elevation AMI, and 3,954 patients with unstable angina hospitalized between 1999 and 2001. The average and median delay times were longest in patients with non-ST-segment elevation AMI (6.1 and 3.0 hours, respectively) followed by patients with unstable angina (5.6 and 3.0 hours) and those with ST-segment elevation AMI (4.7 and 2.3 hours). Approximately 41 p.c. of patients with ST-segment elevation AMI presented to the 94 study hospitals within 2 hours of the onset of acute coronary symptoms; the compared with approximately one third of patients with non-ST-segment elevation AMI and unstable angina. Several demographic and clinical characteristics were associated with prehospital delay. In patients with ST-segment elevation AMI, duration of prehospital delay was inversely related to the receipt of thrombolytic therapy, but was inconsistently related to the use pf percutaneous coronary interventions. The results of this study demonstrate that a large proportion of patients continue to exhibit prolonged delay in seeking medical care after the onset of acute coronary symptoms and remain in need of targeted educational efforts to reduce extent of delay.


    134/2523

    Tytuł oryginału: Fine-needle aspiration biopsy of the thyroid in an area of endemic goitre: influence of restored sufficient iodine supplementation on the clinical significance of cytological results.
    Autorzy: Słowińska-Klencka Dorota, Klencki Mariusz, Sporny Stanisław, Lewiński Andrzej
    Źródło: Eur. J. Endocrinol. 2002: 146 (1) s.19-26, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 301,344

    Hasła klasyfikacyjne GBL:
  • pediatria
  • endokrynologia
  • farmacja
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective: The iodine status of the population of Poland has markedly improved over the past years. The aims of this paper were: (i) to examine the diagnostic, value of fine-needle aspiration biopsy (FNAB) of the thyroid in goitre endemic regions (in conditions of improved iodine supply), and (ii) to find whether the changes in iodine supply have already influenced the clinical interpretation of cytological results. Methods: Cytological diagnoses, based on 3782 aspirates, obtained from 3572 patients during the years 1985-1999, were verified by reference to the results of postoperative examinations. The relative occurrences of selected cytological results in 1992-1999 were also compared (patients not subjected to surgery were included). Results: We have found that the frequenty of neoplastic lesions significantly decreased throughout the examined period (P 0.02). The ratio of the follicular carcinoma frequency increased from 1.7 during 1992-1993 up to 8.0 during 1998-1999 (P 0.05). The frequency of cytologically diagnosed chronic thyroiditis increased from 1.5 p.c. in 1992 to 5.7 p.c. in 1999 (P 0.001); the percentage of cytological diagnosis of 'follicular neoplasm' decreased during the same time (P 0.001). The risk of malignancy significantly lowered in the cytological diagnoses of 'follicular neoplasm' from 15 p.c. during 1985-1993 to 6 p.c. during 1996-1999 (P 0.05). Conclusions: The diagnostic value of FNAM during the period without proper iodine prophylaxis did not differ significantly from that during the last examined period. However, the changes in iodine supply have markedly and promptly affected the clinical significance of particular cytological results.


    135/2523

    Tytuł oryginału: Angiogenesis of endocrine gland tumours - new molecular targets in diagnostics and therapy.
    Autorzy: Stępień H. M., Kołomecki K., Pasieka Z., Komorowski J., Stępień T., Kuzdak K.
    Źródło: Eur. J. Endocrinol. 2002: 146 (2) s.143-151, tab., bibliogr. 96 poz.
    Sygnatura GBL: 301,344

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Angiogenesis in one of the key stages in the development of neoplastic tumours, in which a small group of mutated cells transforms into a large malignant tumour metastasising to the neighbouring tissues and organs. The studies on the significance of neoangiogenesis in the progression of endocrine gland neoplasms have recently become one of the most rapidly evolving branches of molecular endocrinology. The induction of angiogenesis has been demonstrated to result from the imbalance between positive and negative factors which control this process. Our paper presents the results of current studies on the role of factors such as molecular markers of angiogenesis (e.g. vascular endothelial growth factor and basic fibroblast growth factor), metalloproteinases (which regulate the decomposition of the extracellular matrix) and their inhibitors, and adhesive molecules (e.g. soluble vascular cellular adhesion molecule-1 and soluble intracelular adhesion lecule-1) in the pathogenesis and diagnostics of endocrine gland tumours in humans. Also, we discuss new therapeutic strategies for inhibiting the growth of neoplasms by blocking the formation of blood vessels using angiogenesis antagonists, which inhibit various stages of angiogenesis. More and more data are being accumulated suggesting that these preparations could, in the near future, be used in the pharmacotherapy of some endocrine gland neoplasms.


    136/2523

    Tytuł oryginału: O**6-Alkylguanine-DNA-alkyltransferase activity in peripheral leukocytes, smoking and risk of lung cancer.
    Autorzy: Boffetta Paolo, Nyberg Fredrik, Mukeria Anush, Benhamou Simone, Constantinescu Vali, Batura-Gabryel Halina, Brske-Hohlfeld Irene, Schmid Giovanni, Simonato Lorenzo, Pelkonen P„ivi, Hall Janet
    Źródło: Cancer Lett. 2002: 180 (1) s.33-39, tab., bibliogr. 25 poz.
    Sygnatura GBL: 306,023

    Hasła klasyfikacyjne GBL:
  • genetyka
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.

    Streszczenie angielskie: The level of activity of O**6-alkalguanine-DNA-alkytransferase (AGT), a DNA repair enzyme, in blood lymphocytes may be a marker of susceptibility to lung cancer. We measured the AGT activity level, expressed as plomes of repaired bases/mg protein, in leukocytes of 153 lung cancer cases (of whom 80 were never smokers) and 106 controls (76 never smokers) enrolled in eight centres from seven countries. Subjects were interviewed with respect to active smoking and exposure to environmental tobacco smoke (ETS). Among never smokers, the odds ratios (ORs) of lung cancer were 1.3 (95 p.c. confidence interval 0.5-3.9), 1.5 (0.6-4.1) and 1.4 (0.5-3.8) in quartiles of decreasing AGT activity level, as compared to the upper quartile (P value of test for linear trend 0.6). Corresponding ORs among smokers were 3.4 (0.9-13), 2.0 (0.5-8.3) and 0.4 (0.1-1.6) (P value of test for linear trend 0.4). No interaction was suggested between AGT activity level and either cumulative smoking or exposure to ETS. Reduced AGT activity was not clearly associated with increased lung cancer risk in either smokers or non-smokers. However, the small size of our study argues for a prudent interpretation of our results.


    137/2523

    Tytuł oryginału: Contrast echocardiography and medical economics: looking into the crystal ball.
    Autorzy: Distante A., Dankowski R., Mincarone P., Leo C. G., Gianicolo E., Voci P., Morales M. A., Rovai D.
    Źródło: Eur. Heart J. 2002: 4 supl. C s.C39-C47, tab., bibliogr. 78 poz.
    Sygnatura GBL: 306,213

    Hasła klasyfikacyjne GBL:
  • ekonomika
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The past decade has witnessed the development of contrast echocardiography. This technique has demonstrated clinical utility in some applications and extremely promising results have been reported for others, although there are still several obstacles to its acceptance by regulatory authorities and routine users. In addition, the eficacy and cost-effectiveness must be proven against 'gold standard' techniques, which in several cases are just accepted standards. Furthermore, the competition is quite strong both between new techniques and with established ones, and all of the imaging modalities need to find their most appropriate role within this comples environment.


    138/2523

    Tytuł oryginału: Plasma fibrinogen and troponin I in acute coronary syndrome and stable angina.
    Autorzy: Gil Maciej, Zarębiński Maciej, Adamus Jerzy
    Źródło: Int. J. Cardiol. 2002: 83 (1) s.43-46, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We aimed to determine whether there is a stratification among patients with different stages of coronary artery disease with respect to plasma fibrinogen levels, and to assess diagnostic value of plasma fibrinogen in comparison to troponin I in patients with acute coronary syndrome. Fifty-one consecutive patients presenting to our department with acute coronary syndrome within the last 24 h and 52 patients with stable angina with no episode of unstable disease within the last month were analysed. Forty-nine patients with acute coronary syndrome in which both troponin I and fibrinogen levels were prsent were further evaluated. Blood was collected on admission for routine laboratory tests. Statistical analysis was done using Student's t-test, Pearson correlation and chi-square test, P 0.05 being considered statistically significant. Plasma fibrinogen levels (g/l) were significantly higher in patients presenting with unstable than with stable angina (3.87 ń 1.2 vs. 3.26 ń 0.65 P = 0.002). We have found significant correlation between fibrinogen and troponin I levels in coexist and correlate. These results seem to confirm the role of this acute phase protein in the pathophysiology of acute coronary syndrome.


    139/2523

    Tytuł oryginału: Anthrapyridones, a novel group of antitumour non-cross resistant anthraquinone analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells.
    Autorzy: Tarasiuk J., Stefańska B., Plodzich I., Tkaczyk-Gobis K., Seksek O., Martelli S., Garnier-Suillerot A., Borowski E.
    Źródło: Br. J. Pharmacol. 2002: 135 (6) s.1513-1523, il., tab., bibliogr. s. 1522-1523
    Sygnatura GBL: 301,182

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: 1. Multidrug resistance (MDR) to antitumour agents, structurally dissimilar and having different intracellular targets, is the major problem in cancer therapy. MDR phenomenon is associated with the presence of membrane proteins which belong to the ATP-binding cassette family transporters responsible for the active drug efflux leading to the decreased intracellular accumulation. 2. The search of new compounds able to overcome MDR is of prime importance. 3. recently we have synthesized a new family of anthrapyridone compounds. The series contained derivatives modified with appropriate hydrophobic or hydrophylic substituents at the side chain. 4. The interaction of these derivatives with erythroleukina K562 sensitive and K562/DOX resistant (overexpressing P-glycoprotein) cell lines has been examined. The study was performed using a spectrofluorometric method which allows to continuously follow the uptake and efflux of fluorescent molecules by living cells. 5. It was demonstrated that the increase in the lipophilicity of anthrapyridones favoured the very fast cellular uptake exceeding the rate of P-gp dependent efflux out of the cell. For these derivatives, very high accumulation (the same for sensitive and resistant cells) was observed and the in vitro biological data confirmed that these compounds exhibited comparable cytotoxic activity towards sensitive and P-gp resistant cell line. In contrast, anthrapyridones modified with hydrophylic substituents exhibited relatively low kinetics of cellular uptake...


    140/2523

    Tytuł oryginału: Carvedilol does not modulate moderate exercise-induced hyperkalemia in hemodialysis patients.
    Autorzy: Nowicki M., Szewczyk-Seifert G., Klimek D., Kokot F[ranciszek]
    Źródło: Clin. Nephrol. 2002: 57 (5) s.352-358, il., tab., bibliogr. s. 357-358
    Sygnatura GBL: 312,466

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background and aim: Non-selective á-adrenergic blockers may cause yperkalemia in patients with end-stage renal failure. In contrast, ŕ-adrenergic blockade has been found to decrease the hyperkalemic effect of physical exercise in healthy subjects, although we were unable to confirm this effect in hemodialysis patients. In a crossover design, we studied the effect of carvedilol, a non-selective á-adrenergic blocker with an additional ŕ1-blocking activity, on exercise-induced hyperkalemia in 17 anuric hemodialysis patients. Methods: All subjects were hiven either carvedilol (25 mg/day) or placebo for 2 weeks in a random order with a 2-week wash-out period. At the end of each treatment period they underwent a 30-minute exercise test on a bicycle ergometer with a fixed load of 20 W. Results: The treatment with carvedilol caused a significant decrease in blood pressure. Serum potassium before exercise tests was similar (5.37 ń 0.2 and 5.24 ń 0.2 mmol/l on carvedilol and placebo, respectively; mean ń SE). During the exercise, serum postassium oncreased significantly (p 0.001 in both tests) and subsequently decreased during 30 minutes of recovery (p 0.05). The mean rate of potassium increment during the exercise was similar (23.3 ń 3.3 ćmol/min on carvedilol and 20.0 ń 3.6 ćmol/l/min on placebo). during recovery, the mean rate of potassium decrement was 5.0 ń 3.0 ćmol/l/min and 6.7 ń 2.7 ćmol/l/min, respectively. Serum sodium, ionized calcium, insulin and plasma renin activity were similar before the exercise tests and did not change during the exercise. Conclusion: Carvedilol does not enhance the hyperkalemic effect of moderate physical exercise in anuric hemodialysis patients.


    141/2523

    Tytuł oryginału: Expression of intercellular adhesion molecule-1 on the surface of peripheral blood and decidual lymhocytes of women with pregnancy-induced hypertension.
    Autorzy: Wilczyński Jacek R., Banasik Małgorzata, Tchórzewski Henryk, Głowacka Ewa, Malinowski Andrzej, Szpakowski Marian, Lewkowicz Przemysław, Wieczorek Artur, Zeman Krzysztof, Wilczyński Jan
    Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 102 (1) s.15-20, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 305,582

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • in vitro

    Streszczenie angielskie: Objective: If overexpression of intercelular adhesion molecule-1 (CD54) on lymphocytes exists it could have important implications for the pathophysiology of pregnancy-induced hypertension (PIH). Study design: CD54 "in vitro" expression (described as (p.c.) of CD54 + cells and CD54 mean fluorescence intensity, MFI) on the peripheral blood and decidual lymphocytes of pregnant with preeclampsia (PE) (n = 16), transient hypertension (TH) (n = 12), and controls (n = 9). Results: The percent (p.c.) of CD54 + peripheral blood lymphocytes, CD54 MFI on them and CD54 MFI on decidual lymphocytes were increased especially in PE. During PE the (p.c.) of CD54 decidual lymphocytes correlated negatively with platelet count. In TH the positive correlation between the blood pressure and the (p.c.) of CD54 peripheral blood lymphocytes as well as CD54 MFI on decidual lymphocytes were found. Conclusions: (1) PIH, especially PE, is accompanied by overexpression of intercellular adhesion molecule-1 (ICAM-1) on peripheral blood and decidual lymphocytes studied "in vitro", (2) Some of the parameters studied seem to correlate with clinical markers of PIH intensity but this fact needs further investigations using larger subject groups.


    142/2523

    Tytuł oryginału: A multicentre randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time.
    Autorzy: Hliniak A., Gwiazdowska B., Szutkowski Z., Kraszewska E., Kukolowicz P., Jarząbski A., Sochacka B., Mazurkiewicz M., Paprota K., Oliskiewicz W., Zadrożna O., Milecki P., Kubiak M., Czopkiewicz L., Jagas M., Góźdź S., Wieczorek A., Woytowicz A., Cisowska B., Magdziarz H., Nowakowski S., Kośniewski W., Laskosz I., Serafin A., Gradoń E.
    Źródło: Radiother. Oncol. 2002: 62 (1) s.1-10, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 312,846

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background and purpose: To compare in a phase III study the loco-regional control, disease-free survival and overall survival induced by an accelerated regimen (AF) as compared with conventional regimen (CF) and to analyze the early and late post-radiation morbidity in both arms. Materials and methods: Patietns with ó 75, WHO 0-1, suitable for a radical course of radiotherapy T1-T3, NO, MO, stage of glottic and supraglottic laryngeal cancer were randomized to either CF: 66Gy given in 33 fractions over 45 days or AF: 66Gy given in 33 fractions over 38 days (2 fractions every Thrusday). A total of 395 patients were included from 05.1995 to 12.1998. Results. Early toxicity: At the end of radiotherapy patietns treated with AF complained for more severe reactions than patients treated with CF. In 8 weeks after treatment completion patients treated with AF complained only for more severe pain on swallowing (P = 0.027). In 4 months after treatment completion all types of toxicity except for skin teleangiectasia (P = 0.001) were similar in the two groups. Locoregional control: comparison between CF and AF showed no difference in terms of loco-regional control (P = 0.37). Conclusions: The improvement in AF in terms of loco-regional control is estimated to be 3-5 p.c. in comparison with conventional regimen and is not significant. The intensity of reactions after 4 months was similar in both arms, what suggests the possibility of further shortening of the overall time by few days or enhancing the total dose within the limits of acceptable morbidity.


    143/2523

    Tytuł oryginału: The pathomechanism of posttraumatic edema of lower limbs. [P.] 1: The effect of extravasated blood, bone marrow cells, and bacterial colonization on tissues, lymphatics and lymph nodes.
    Autorzy: Szczęsny Grzegorz, Olszewski Waldemar L.
    Źródło: J. Trauma 2002: 52 (2) s.315-322, il., bibliogr. 31 poz.
    Sygnatura GBL: 305,046

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • psy
  • in vitro

    Streszczenie angielskie: Bacground: The mechanical injury of soft tissues and bones of lower extremities is frequently followed by long-lasting edema at the site of trauma and distally. The pathomechanisms of this complication remains unclear. Venous thrombosis and interruption of lymphatics are considered to be the main etiologic factors. We propose a concept that protracted healing of injured tissues and bones with involvement of the regional lymphatic system (lymphatics and nodes) is responsible for persistence of edema. The events affecting the first (scavenging) phase of healing of traumatized tissues, such as hematoma, translocation of bone marrow cells to soft tissues, and colonization by microorganisms, and in particular their effects on lymphatics and lymph nodes, were studied. Methods: Mongrel dogs weighing 15-20 kg were. Fresh blood or bone marrow cell (BMC) suspension was injected subcutaneously or intralymphatically into the paw. Strains of saprophyte bacteria residing on the skin surface were cultured and injected intradermally. Oilcontrast lymphography was performed before and after injections to evaluate the changes in lymphatics and nodes. Biopsy samples of paw skin, subcutaneous tissue, and regional lymph nodes (LN) were taken. The responsiveness of LN lymphocytes was studied in autologous mixed cultures with peripheral blood lymphocytes (PBL), BMC, and cultured bacteria. Results: The PBL from subcutaneously injected blood were evacuated by the lymphatic route at a rate of 1-3 proc./6 hr. There was no thrombosis of lymphatic vessels or obstruction of LN sinusoids...


    144/2523

    Tytuł oryginału: Long-term changes in calbindin D28K immunoreactivity in the rat hippocampus after cardiac arrest.
    Autorzy: Sadowski Marcin, Lazarewicz Jerzy W., Jakubowska-Sadowska Katarzyna, Wiśniewski Henryk M., Mossakowski Mirosław J., Brown W. Ted
    Źródło: Neurosci. Lett. 2002: 321 (1/2) s.90-94, il., bibliogr. 20 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Calbindin D28K (CB) expression was analyzed in the rat hippocampus following 10-min-cardiac arrest-induced ischemia within a year after reperfusion. In rats examined 3 days after ischemia, CB immunoreactivity disappeared completely from CA1 pyramidal neurons and from most CA2 pyramids. In the stratum granulosum of the dentate gyrus, mossy fibers, and hippocampal interneurons, CB immunoreactively was preserved, although staining was somewhat paler than that in control rats. A similar pattern of CB immunoreactively was found in rats sacrificed 14 days and 1 month after cardiac arrest. From the 14th postischemic day, neuronal loss in the stratum pyramidale of CA1 but not in that of CA2 became apparent. The reappearance of CB immunoreactivity in CA1 and CA2 pyramidal neurons was noticed 6 months after ischemia, and the pattern was identical to that observed in animals sacrificed 12 months after the octus. The prolonged loss and delayed reappearance of CB immunoreactivity in the hippocampus demonstrate that ischemia may induce long-term disturbances of protein expression, which may in turn result in impairment of hippocampal functioning.


    145/2523

    Tytuł oryginału: Induction of oxidative DNA damage by carcinogenic metals.
    Autorzy: Bal Wojciech, Kasprzak Kazimierz S.
    Źródło: Toxicol. Lett. 2002: 127 (1/3) s.55-62, bibliogr. s. 60-62
    Sygnatura GBL: 306,158

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also include Co, Cu, Fe and Pt. A range of molecular mechanisms was proposed for these metals, reflecting their diverse chemical properties. The oxidative concept in metal carcinogenesis proposes that some complexes of the above metals (Co, Cr, Cu, Fe, Ni) formed in vivo undergo redox cycling, yielding reactive oxygen species and/or high valence metal ions which oxidize DNA. Some of the products of oxidative DNA damage, including 8-oxoguanine and strand breaks, induce mutations, which may lead to neoplastic transformation. The establishment of metal-binding modes in the cell nucleus and of their reactivity is crucial for the understanding of molecular events in metal carcinogenesis. We have proposed the binding sites for Ni(II) and Cu(II) in core histones (H3, H2A) and sperm protamines (HP2) and, using molecular models, provided evidence for the generation of promutagenic oxidative DNA damage by the bound metals.


    146/2523

    Tytuł oryginału: Recent advances in understanding of the molecular basis of anhidrotic ectodermal dysplasia: discovery of a ligand, ectodysplasin A and its two receptors.
    Autorzy: Wiśniewski Sławomir A., Kobielak Agnieszka, Trzeciak Wisław H., Kobielak Krzysztof
    Źródło: J. Appl. Genet. 2002: 43 (1) s.97-107, il., tab., bibliogr. (42) poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Recent developments of the investigations on the molecular basis of anhidrotic ectodermal dysplasia are reviewed. Identification of the major product of the EDA gene (ectodysplasin A), a protein belonging to a group of TNF ligands, and molecular cloning of the cDNA, encoding its receptor (EDAR), a member of the RNF receptor family, are presented. The role of an alternative EDA receptor, localised on the X chromosome (XEDAR) in the development control of the differentiation of skin appendages, is discussed. Recent findings ave elucidated the cause of the autosomal forms of EDA, both dominant and recessive, and indicated an important role of a signal transduction pathway involving a protein product of the NEMO gene and the transcription factor NFkB in the differentiation of skin appendages.


    147/2523

    Tytuł oryginału: Transition C2718T in the AR gene, resulting in generation of a termination codon and truncated form of the androgen receptor, causes complete androgen insensitivity syndrome.
    Autorzy: Ignacak Monika, Niedziela Marek, Trzeciak Wiesław H.
    Źródło: J. Appl. Genet. 2002: 43 (1) s.109-114, il., tab., bibliogr. (14) poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • pediatria
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The action of testosterone and 5ŕ-dihydrotestosterone are essentail to the development of the male phenotype. Patients with karyotype 46,XY, resistant to these hormones, exhibit a wide spectrum of phenotypes: from phenotypic female, through a range of incomplete masculinization, to under-virilized, infertile man. Theses disturbances are caused by mutations in the androgen receptor gene (AR). We studied a 46,XY fenotypic female with typical symptoms of Complete Androgen Insensitivity Syndrome (CAIS). Multiple temperature single-stranded confirmation polymorphism (MSSCP) an sequence analysis of exon 6 of the AR gene in a patient revealed a C2718T transistion causing R786X mutation in the loop between helices VII and VIII of the LBD of the androgen receptor. The R786X mutation has been described in a patient with CAIS only once and no such mutations have been described in Eastern Europe.


    148/2523

    Tytuł oryginału: Trisomy 8 mosaicism syndrome.
    Autorzy: Wiśniewska Marzena, Mazurek Małgorzata
    Źródło: J. Appl. Genet. 2002: 43 (1) s.115-118, il., bibliogr. (7) poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: Authors present the case of a 15-year-old boy assessed for Marfan syndrome for many years. The child was treated because of skeletal defects, mild mental deficiency and dysmorphic features of face. Chromosomal analysis showed a trisomy 8 mosaicism.


    149/2523

    Tytuł oryginału: Mirosław J. Mossakowski in memoriam [1929-2001].
    Autorzy: Albrecht Jan
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.I-II, il.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Mossakowski
  • Mirosław Jan 1929-2001


    150/2523

    Tytuł oryginału: Proteolysis of endomorphin-1 by brain synaptic membrane-associated peptidases.
    Autorzy: Wu Liming, Chen Junhui, Zhong Dulai, Lin Chentao, Wang Xingchang
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.1-5, il., bibliogr. [15] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The biotransformation of endomorphin-1 (EM-1) by brain synaptic membranes has ben studied. Peptide fragments of EM-1 that were formed during incubation with membrane preparations in vitro were isolated by High-performance liquid chromatography (HPLC) and characterized using determination of amono acid composition. At pH 7.4, two degradation products, EM-1(1-3) and EM-1(1-2), were identified. EM-1 was degraded 77.5 p.c. at 30 min incubation with synaptic membranes. The time course of the experiments and the effect of carboxypeptidase inhibitor (CPI) demonstrated that the proteolysis reaction involves the participation of carboxypeptidase activity.


    151/2523

    Tytuł oryginału: The time course of the last contractions during incompletely fused tetani of motor units in rat skeletal muscle.
    Autorzy: Celichowski Jan, Bichler Edyta
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.7-17, il., tab., bibliogr. [42] poz.
    Sygnatura GBL: 302,090

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The time course of the contraction and the relaxation of individual contractions during incompletely fused tetani of motor units were analyzed. Investigations were performed on fast fatigable (FF), fast resistant (FR) and slow (S) motor units of the rat medial gastrocnemius muscle. Stimulation of a motor unit with a series of nine trains of stimuli at a frequency from 10 to 150 Hz was used and tetani fused to a variable degree were recorded. For fast motor units the procedure was repeated twice and observations were made on potentiated tetani in the second series of stimulation. For each tetanus, the amplitude of the tension increase, the peak amplitude of the contraction, the contraction time and the half-relaxation time were measured in the last contraction of the tension recording. It was observed in all three types of motor units that the last contraction was prolonged in parallel with the increase of fusion of a tetanus. In this contraction, the contraction time slightly decreased whereas the half-relaxation time strongly prolonged. The prolongation of the half-relaxation time was the strongest in tetani of slow units. Moreover, for the last contraction in a tetanus, the rate of changes in tension were studied. The rate of increase in tension during the contraction decreased in parallel with the increase of fusion of a teatanus, whereas the maximal rate of the tension decrease during the relaxation was found in tetani with fusion indices of 0.79, 0.98 and 0.95 for FF, FR and S motor units, respectively. Changes in the time course of contractions in tetani to a variable degree can shed light on processes of summation of contractions in unfused tetani at the level of individual motor units.


    152/2523

    Tytuł oryginału: Superior laryngeal nerve section abolishes capsaicin evoked chemoreflex in anaesthetized rats.
    Autorzy: Kaczyńska Katarzyna, Szereda-Przestaszewska Małgorzata
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.19-24, il., bibliogr. [21] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • farmacja
  • pulmonologia
  • neurologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Respiratory effect of an intravenous injection of capsicin were investigated in nine vagotomized and subsequently laryngeally deafferentated, urethane- and chloralose- anaesthetized and spontaneously breathing rats. Bolus injection of capsaicin (5 ćg/kg) into the right femoral vein induced an expiratory apnoea of 4.23 ń 0.63 s duration (mean ń SEM). In post-apnoeic breathing, tidal volume increased by 14 p.c. from the control level (P 0.05) in all nine rats treated by vagotomy. Section of the superior laryngeal nerves (SLNs) precluded the occurrence of apnoea. Results of this study indicate that in vagotomized rats sensory input from the larynx constitute an important pathway to the nodose ganglia endowed with capsaicin receptors.


    153/2523

    Tytuł oryginału: Effects of social rearing conditions on conditioned suppression in rats.
    Autorzy: Walasek Grażyna, Węsierska Małgorzata, Werka Tomasz
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.25-31, il., bibliogr. [34] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: mwenty-two rats were reared in standard conditions during the first two months of their life. Then the animals were divided into two groups exposed to different rearing conditions. Twelve animals (Group SO) were housed socially, six animals per cage, and for three weeks they were subjected to sensory stimulation in an enriched environment. The other ten subjects were kept individually (Group IN); one rat per mesh cage, in conditions of relatively impoverished sensory stimulation. In both groups the training of the conditioned emotional response (CER) was performed when animals were three months old. In contrast to IN subjects, the rats subjected to permanent social contacts and reared in the enriched environment (Group SO) revealed almost equally low instrumental response rates in trials with the conditioned stimulus (CS) paired with nociceptive foot-shock (US), and in period when no CS and/or US were applied. The results suggested that early exposure to an enriched environment caused a later decrease of the animals' capability to differentiate between the aversive CS and cues of the experimental context. This cognitive impairment was probably a secondary efffect of fear generalized to the entire experimental situation.


    154/2523

    Tytuł oryginału: Perception of facial affect in chronic schizophrenia and right brain damage.
    Autorzy: Kucharska-Pietura Katarzyna, Klimkowski Marceli
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.33-43, il., tab., bibliogr. [52] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: This study was designed to compare the performance of 50 chronic schizophrenics (CS) to that of 30 right brain-damaged patients (R), and 50 healthy controls (N) on several facial perception measures: Emotion Labelling and Recognition, and the Benton Facial Recognition Test. CSs were diagnosed according to DSM-IV criteria and their psychiatric state was assessed using the PANSS scale. All subjects were right handed. Their cognitive state was assessed using the MMSE. Subjects rated their current mood on a visual analogue scale. The results showed that the CSn and Rs were significantly impaired compared to Ns for the emotional tasks but did not differ from each other. Moreover, the patient groups were significantly less accurate in recognising emotionally neutral facial stimuli. Each subject group had more difficulty processing negative relative to positive affect. The deficit in schizophrenia was found to be stable, which may reflect a trait-like, rather than a state-dependent, characteristic. Moreover, some support is provided for the notion that facial affect perception in chronic schizophrenia is associated with right hemisphere dysfunction.


    155/2523

    Tytuł oryginału: Hypoxic damage of the cerebellum in 7-day-old rats. Ultrastructural and histochemical study.
    Autorzy: Dąmbska Maria, Gajkowska Barbara
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.45-49, il., bibliogr. [15] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The damaging influence of hypoxia on the cerebellum in immature rats, which is still discussed, was investigated. Using material obtained in a modified Levine model for combined hypoxic-ischemic damage in 7-day-old rats, we examined changes in cerebellum submitted to hypoxia only. The results demonstrated classic features of hypoxic nervous tissue damage and calcium accumulation in mitochondria and endoplasmic reticulum. This was investigated using electron microscopy combined with the oxalate-pyroantimonate method. We propose that Caý+ increases in endoplasmic reticulum and mitochondrial Caý+ pools may be involved in damage-mediated mechanisms. These results support a role of calcium as a mechanism of cerebellar cell loss after this form of injury.


    156/2523

    Tytuł oryginału: Centrally applied vasopressin prevents posthemorrhagic hypotension in WKY rats.
    Autorzy: Ufnal Marcin, Żera Tymoteusz
    Źródło: Acta Neurobiol. Exp. 2002: 62 (1) s.51, il.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • kardiologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    157/2523

    Tytuł oryginału: Serum concentrations of markers of type I collagen metabolism in women taking monophasic oral contraceptives.
    Autorzy: Rechberger Tomasz, Baranowski Włodzimierz, Bogusiewicz Michał, Postawski Krzysztof, Jakimiuk Artur J., Tomaszewski Jacek, Kulik-Rechberger Beata, Jakowicki Jerzy A.
    Źródło: Ginekol. Pol. 2002: 73 (2) s.81-86, il., tab., bibliogr. 21 poz., streszcz.
    Sygnatura GBL: 301,184

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Karboksyterminalny propeptyd kolagenu typu I (PICP-carboxy-terminal propeptide of type I procollagen) i stabilizowany pirydynoliną karoboksyterminalny telopeptyd kolagenu typu I (ICTP - cross-linked carboxy-terminal telopeptide of type I collagen) są markerami odpowiednio rozpadu i synetzy kolagenu typu I. Ich stężenia w surowicy krwi odzwierciedlają tempo przemian tego białka w organizmie. Oznaczono stężenia PICP i ICTP w surowicy kobiet przyjmujących doustne środki antykoncepcyjne zawierające 20 ćg etinylestradiolu i 150 ćg desogestrelu (Mercilon) lub 30 ćg etinylestradiolu i 150ćg desogestrelu (Marvelon) przez 6 miesięcy. Stwierdzono znamiennie niższe średnie stężenie PICP po 3 miesiącach przyjmowania preparatu zawierającego 20 ćg etinylestradiolu i 150 ćg desogestrelu, które jednak po 6 miesiącach nie różniło się istotnie od wartości poczatkowej. U kobiet przyjmujących preparat zawierający 30 ćg etinylestradiolu i 150 ćg desogestrelu nie zaobserwowano znaczących zmian stężenia PICP. Średnie stężenia ICTP nie uległy istotnym zmianom w obu grupach. Wyniki wskazują na przemijające zmniejszenie syntezy kolagenu typu I u kobiet przyjmujących środki antykoncepcyjne zawierające 20 ćg etinylestradiolu. Żaden z obu badanych preparatów nie wpływa znacząco na degradację kolagenu typu I w organizmie kobiet podczas pierwszych sześciu miesięcy przyjmowania.

    Streszczenie angielskie: Objectives: To investigate serum concentrations of the carboxy-terminal of type I procollagen (PICP) and cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), reflecting the rate of synthesis and degradation of the parent collagen respectively, in women using monophasic oral contraceptives. Study design: PICP and ICTP were estimated in 60 women taking 20 ćg of ethinyl estradiol (EE) + 150 ćg of desogestrel (DSG) or 30 ćg of EE + 150 ćg DSG over six months. Results: Mean PICP concentration decreased in women receiving 20 ćg of EE + 150 ćg of DSG after three cycles of administration. However, after six months this value returned to a leel comparable to the initial one. In women taking 30 ćg of EE + 150 ćg of DSG the mean concentrations of PICP did not change significantly throughout the period studied. None of the oral contraceptives noticeably influenced the concentrations of ICTP. Conclusion: Investigated oral contraceptives do not significantly affect the metabolism of type I collagen, however a transient decrease in its biosynthesis may be expected during the use of formulations containing 20 ćg of EE.


    158/2523

    Tytuł oryginału: Evaluation of the antisperm antibodies in infertile couples afflicted with a cervical factor.
    Autorzy: Rogoza Andrzej, Łukaszuk Krzysztof, Mielcarek Piotr
    Źródło: Ginekol. Pol. 2002: 73 (2) s.87-92, il., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 301,184

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Dokonano oceny metod stosowanych w wykrywaniu przeciwciał przeciwplemnikowych w diagnostyce niepłodności immunologicznej. Materiał stanowiło 38 par leczonych w II Klinice Położnictwa i Ginekologii AMG z powodu podejrzenia niepłodności immunologicznej. Na podstawie przeprowadzonych badań stwierdzono małą przydatność diagnostyczną lateksowego testu aglutynacji. Jako podstawową metodę wykrywania przeciwciał przeciwplemnikowych proponujemy metodę Western blottingu.

    Streszczenie angielskie: Objectives: The purpose of this study was to evaluate methods used for antisperm antibodies detection in infertility. Methods: The studied cohort comprised 38 infertile couples with a distinct cervical factor. Presence of antisperm antibodies and their levels in circulation were evaluated in sera samples of both partners and also in the cervical mucus and semen with the Latex Agglutination test. Western Blotting was applied as an additional method in antibody detection. We also assessed: the number of sexual partners, potentially allergizing sexual behaviour and other potentially sensitising factors. Results: The positive antisperm antibodies were detected merely twice and only in one case there was evidence of insemination-impeding antisperm humoral response. The Western Blotting method enabled us to obtain a reaction to a range of sperm proteins which reaction to a range of sperm protein which reacted with antibodies both in serum and in seminal plasma. Conclucions: Determination of infertility on immunological grounds on the basis of a single determinant on sperm presents little diagnostic value. In our view, the combination of patient's clinical status with immune-system response to a spectrum of sperm antigens provides means of infertility evaluation. We propose Western Blotting as an useful technique for detection of antisperm antibodies.


    159/2523

    Tytuł oryginału: Novye struktury 0-cpecificheskikh polisakharidov bakterijj roda Proteus. 2: Polisakharidy, soderzhashhie O-acetilnye gruppy.
    Tytuł angielski: New structures of the O-specific polysaccharides of Proteus. [P.] 2: Polysaccharides containing O-acetyl groups.
    Autorzy: Kondakova A. N., Toukach F. V., Senchenkova S. N., Arbatsky N. P., Shashkov A. S., Knirel Y. Ju., Zych K., Torzewska A., Rożalski A., Kołodziejska K., Sidorczyk Z.
    Źródło: Biokhimija 2002: 67 (2) s.240-252, il., tab., bibliogr. 36 poz., sum.

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Structures of five new O-specific polysaccharides of the lipopolysaccharides of bacteria Proteus were established. Four of them, Proteus penneri 4 (072), Proteus vulgaris 63/57 (037), Proteus mirabilis TG 277 (069), and Proteus penneri 20 (017), contain O-acetyl groups in non-stoichiometric quantities, and the polysaccharide of P. penneri 1 st structuraly related to that of P. penneri 4. The structures were elucidated using NMR spectroscopy, including one-dimensional 1H nd 13C NMR, two-dimensional 1H, 1H correlation (COSY, TOCSY), 1H, 13C heteronuclear multiple-quantum coherence (HMQC) and multiple-bond correlation spectroscopy, as well as nuclear Overhauser effect spectroscopy (NOESY or ROESY), along with chemical methods. The structural data obtained are useful as the chemical basis for the creation of the classification scheme for Proteus strains.


    160/2523

    Tytuł oryginału: Novye struktury O-specificheskikh polisakharidov bakterijj roda Proteus. 1: Fosfatsoderzhashhie polisakharidy.
    Tytuł angielski: New structures of the O-specific polysacchardies of Proteus. [P.] 1: Phosphate-containing polysaccharides.
    Autorzy: Toukach F. V., Kondakova A. N., Arbatsky N. P., Senchenkova S. N., Shashkov A. S., Knirel Y. A., Zych K., Rożalski A., Sidorczyk Z.
    Źródło: Biokhimija 2002: 67 (2) s.318-331, il., tab., bibliogr. 23 poz., sum.

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: The O-specific polysaccharide chains (O-antigens) of the lipopolysacchardides of five Proteus strains, P. vulgaris 017, P. mirabilis 016 and 033, and P. penneri 31 and 103, were found to contain phosphate groups that link the non-sugar components, namely, ethanolamine and ribitol. From them, the polysaccharides of P. mirabilis 016 and P. penneri 103 include ribitol phosphate in the main chain and thus resemble ribitol teichoic acids of Gram-positive bacteria. The structures of the polysaccharides were elucidated using NMR spectroscopy, including two-dimensional 1H, 1H correlation spectroscopy (COSY and TOCSY), nuclear Overhauser effect spectroscopy (NOESY or ROESY), and H-detected 1H, 13C, and 1H, 31P heteronuclear multiple-quantum coherence (HMQC), along with chemical methods. The structures determined are unique among the bacterial polysaccharides and, together with data obtained earlier, represent the chemical basic for classification of Proteus strains. Based on structural similarities of the O-specific polysaccharides and serological relationships between the O-antigens, we propose to add P. penneri strain 31 to serogroup 019 and to extend serogroup 017 by including P. penneri strain 16.


    161/2523

    Tytuł oryginału: Further studies on the anti-oxidative effect of putrescine in sodium nitrite-treated rats.
    Tytuł polski: Dalsze badania nad antyoksydacyjnym wpływem putrescyny u szczurów zatruwanych azotynem sodowym.
    Autorzy: Grudziński Ireneusz P., Frankiewicz-Jóźko Anna
    Źródło: Rocz. Państ. Zakł. Hig. 2002: 53 (1) s.11-17, il., bibliogr. 30 poz., streszcz.
    Sygnatura GBL: 301,906

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Badano antyoksydacyjne właściwości putrescyny (10 mg/kg m.c./dzień) u szczurów zatruwanych per os azotynem sodowym (10 mg NaNO2/kg m.c./dzień) przez okres 14 dni. Putrescynę podawano per os w 3-4 godz. po podaniu azotynu i/lub 0,9 p.c. NaCl (kontrola) przez okres 7 dni (dzień 7-14). Azotyn sodowy zwiększył poziom substancji reagujących z kwasem tiobarbiturowym (TBARS) w błonie śluzowej jelita cienkiego i wątrobie, nie wpływając na zmiany tego parametru we krwi szczurów. Nie wykazano, aby u zwierząt zatruwanych azotynem dochodziło do zmian zarówno stanu antyoksydacyjnego surowicy (TAS) oraz aktywności dysmutazy ponadtlenkowej (SOD) we krwi, wątrobie czy błonie śluzowej jelita cienkiego. Podawanie szczurom putrescyny zmniejszyło poziom TBARS w badanych tkankach przy zwiększonym poziomie TAS w surowicy. Putrescyna znacząco obniżyła aktywność SOD w wątrobie i krwi i nie zmnieniając aktywności tego enzymu w jelicie cienkim. Rezultaty badań sugerują, że podawanie putrescyny per os szczurom może prowadzić do obniżenia peroksydacji lipidowej indukowanej azotynem sodowym.

    Streszczenie angielskie: Studies were carried out to elucidate the anti-oxidative effect(s) of putrescine (10 mg/kg b.w./day) in rats treated per os with either sodium nitrite (10 mg/kg b.w./day) or normal saline (control) for 14 days. The putrescine was given to rats for 7 days only (days 7-14) and it was introduced 3-4 hrs after nitrite or saline dosage. Sodium nitrite increased thiobarbituric acid reactive substances (TBARS) in rat small intestinal mucosa and liver, and the agent did not have any effect on the total anti-oxidant status (TAS) and lipid peroxidation of rat blood. Nitrite did not also change the activity of superoxide dismutase (SOD) in the small intestinal mucosa, liver and blood, as well. Pretreatment of nitrite-treated rats with putrescine decreased TBARS and increased TAS in animals. Putrescine decreased SOD activity in the blood and liver of nitrite- and/or saline-treated rats, however, the agent did not affect the SOD enzyme in the small intestinal mucosa. Results suggest that putrescine dosed to nitrite-treated rats possesses some anti-oxidative properties.


    162/2523

    Tytuł oryginału: A pilot study on the histochemical evaluation of Na/K-ATPase and succinate dehydrogenase in rat intestinal villi.
    Tytuł polski: Badania pilotowe nad histochemiczną oceną ATPazy-Na/K oraz dehydrogenazy bursztynianowej w kosmkach jelita cienkiego szczura.
    Autorzy: Grudziński Ireneusz P.
    Źródło: Rocz. Państ. Zakł. Hig. 2002: 53 (1) s.19-26, il., bibliogr. 31 poz., streszcz.
    Sygnatura GBL: 301,906

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Badano wpływ zatrucia azotynem sodowym na aktywność ATPazy-Na/K oraz dehydrogenazy bursztynianowej (SDH) w błonie śluzowej jelita cienkiego szczurów. Zwierzęta otrzymywały per os wodny roztwór azotynu sodowego (10 mg NaNO2/kg m.c.) i/lub 0,9 proc. roztwór chlorku sodowego (kontrola) przez okres 3 i 12 tygodni. Histoenzymatyczna analiza wykazała azotynowe obniżenie aktywności ATPazy-Na/K oraz SDH w kosmkach jelitowych ze szczególnym nasileniem wpływu azotynu w 12 tygodniu zatrucia zwierząt.

    Streszczenie angielskie: Effects of poisoning with sodium nitrite on Na/K-ATPase and succinate dehydrogenase (SDH) activity were examined in the small intestine mucosa of male Wistar rats. The animals were treated per os with either an aqueous solution of sodium nitrite (10 mg NaNO2/kg b.w.) or normal saline (control) daily for 3 or 12 weeks. Histochemical analyses show that sodium nitrite decreased Na/K-ATPase and SDH in rat intestinal villi, and the nitrite side effect(s) was mainly observed in animals treated for 12 weeks.


    163/2523

    Tytuł oryginału: CD45 in memory and disease.
    Autorzy: Tchilian Elma Z., Beverley Peter C. L.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.85-93, il., bibliogr. 72 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: CD45 (the leukocyte common antigen) is known to function as a tyrosine phosphatase in leukocyte signaling. Biochemical studies indicate that CD45 is involved in the regulation both of T cell receptor-associated kinases and Janus kinases that transmit signals from cytokine receptors. However, the function of the different isoforms of CD45 generated by complex alternative splicing, and indeed the role of the whole extracellular domain of the molecule, remain mysterious. Analysis of CD45 knock-outs and of trangenic mice expressing single CD45 isoforms, as well as the disease associations of human polymorphisms, is providing new insights into CD45 function. Accumulating data from these genetic and biochemical studies promises to elucidate the role of high and low molecular weight isoforms of CD45 in the function of naive and memory T lymphocytes.


    164/2523

    Tytuł oryginału: Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.
    Autorzy: Bottini Nunzio, Bottini Egidio, Gloria-Bottini Fulvia, Mustelin Tomas
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.95-104, tab., bibliogr., 80 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: A major challenge in the post-genomic era is to identify the physiological functions of genes and elucidate the molecular basis for human disease. Genetic polymorphisms offer a convenient avenue for these efforts by providing evidence for the involvement of a given gene in human pathophysiology. Here we review the current evidence linking the low-molecular weight protein tyrosine phosphatase (LMPTP) to several common diseases, including allergy, asthma, obesity, myocardial hypertrophy, and Alzheimer's disease. Based on the known effects of the genetic polymorphisms on the alternative mRNA splicing and enzyme levels of LMPTP, we discuss the possible molecular mechanisms of LMPTP ivolvement in these diseases.


    165/2523

    Tytuł oryginału: Archivum Immunologiae et Therapiae Experimentalis!
    Tytuł angielski: Significance of tumor-cell receptors in human cancer.
    Autorzy: Żeromski Jan
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.105-110, il., bibliogr. 48 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • onkologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Every tumor cell is equipped with an array of biologically active surface molecules, and several of these function as receptors for various ligands. They include MHC, or in the case of humans, HLA antigens, cytokine receptors, cell-adhesion molecules, growth factor receptors, Fas/Fas-ligand molecules and others. Their expressions are a subject to alternations, usually to the advantage of tumor growth and spread. Some appear on tumor cells de novo, having no counterparts on the respective normal cells. Detailed knowledge about the expression of tumor-cell receptors and their genotypes, in particular of cancerous ones, may provide information essential for the creation of tools for specific tumor immunotherapy.


    166/2523

    Tytuł oryginału: Potential for immune reconstitution through G-CSF treatment of HIV patients.
    Autorzy: Aulock Sonja von, Hartung Thomas
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.111-120, il., bibliogr. 90 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • farmacja
  • aIDS
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: New treatment strategies for HIV/AIDS are very successful in reducing viral load. However, reconstitution of the immune system takes about one year and may be insufficient or remain incomplete. During this time the patient remains prone to opportunistic infections as a result of the complex immune dysfunction caused by the virus. Recombinant granulocyte colony-stimulating factor (G-CSF) has diverse immunomodulatory properties which may be beneficial in aiding immune reconstitution.


    167/2523

    Tytuł oryginału: GM-CSF regulation in eosinophils.
    Autorzy: Esnault St‚phane, Malter James S.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.121-130, bibliogr. 113 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizingits coding mRNA.


    168/2523

    Tytuł oryginału: Immunomodulation of macrophages by pathogenic Yersinia species.
    Autorzy: Ruckdeschel Klaus
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.131-137, il., bibliogr. 37 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The interaction between macrophages and bacterial pathogens plays a crucial role in the pathogenesis of infectious diseases. Pathogenic species of the Gram-negative bacterium Yersinia deploy complex strategies to disarm macrophages and to disrupt their response to infection. For this purpose, Yersinia sp. engage a type III protein secretion system that mediates the polarized translocation of Yersinia virulence factors, the so-called Yops (Yersinia outer proteins), into the host cell cytoplasm. There, the Yops act on different cellular levels to neutralize a sequence of programmed phagocyte effector functions. Yersiniae initially impair the phagocytic machinery and block the generation of th ebacterial oxidative burst. Furthermore, yersiniae uncouple an array of fine-tuned signals of innate immunity, which leads to suppression of macro\hage TNF-ŕ production and to macrophage apoptosis. The impairment of cellular functions results in a scenario by which Yersinia efficiently resists the attack of the macrophage and finally kills the macrophage by activating its intrinsic cell suicide mechanism. This review highlights the aspects of Yersinia-macrophage interaction that determine the fate of the infected cell.


    169/2523

    Tytuł oryginału: Effect of IL-18 on IL-1á and sIL-1RII production.
    Autorzy: Jabłońska Ewa, Iżycka Aneta, Wawrusiewicz Natalia
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.139-141, il., bibliogr. 7 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study we investigated the effect of interleukin 18 (IL-18) on th e production of IL-1ánd soluble IL-1 receptor II (sIL-1RII) by human neutrophils. The results obtained indicate that recombinant human IL-18 (rhIL-18) induces IL-1á and, to a lesser extent, sIL-1RII production by human neutrophil isolated from peripheral blood. However, this effect was less important than lipopolysaccharide (LPS) stimulation. Additionally, our observations suggest that IL-18 can induce priming of neutrophils for IL-1á and, to a lesser extent, sIL-1RII production by LPS-stimulated cells. The ability of IL-18 to serve as an effective modulator for IL-1áand its regulatory protein may have sigificance in the inflammatory and immune reactions mediated by IL-1á.


    170/2523

    Tytuł oryginału: A study of thyroglobulin concentration in the thyroid and serum of patients with different thyroid disorders.
    Autorzy: Czarnywojtek Agata, Krysińska Iwona, Łącka Katarzyna, Stawny Bolesław, Rólski Michał, Jarząb Barbara, Włoch Jan, Gembicki Maciej
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.143-148, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • pediatria
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Knowledge concerning the structure and quality of thyroglobulin (tg) has great significance for the better understanding of the pathogenesis of different thyroid diseases. The localization of the Tg gene and studies of its structure by molecular biological techniques make possible precise investigations of its expression. The aim of our study was to evaluate Tg content in the thyroids and Tg concentrations in the serum of 108 patients suffering from beenign or malignant thyroid disorders. The method of investigation was isolating total protein from thyroid tissues obtained during surgery and determining Tg content in the thyroid extracts and Tg concentrations in serum The Tg concentrations in serum and in thyroid protein extracts were evaluated by fluoroimmunometric assay. Statisctical analysis was carried out with the help of the computing programmes.


    171/2523

    Tytuł oryginału: Single photon emission tomography in radioimmune imaging of diabetic foot infection.
    Autorzy: Bohchelian H. A., Klisarova A. D., Koeva L. A.
    Źródło: Diabetol. Pol. 2002: 9 (1) s.39-44, il., tab., bibliogr. 24 poz., sum.
    Sygnatura GBL: 313,197

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of our study was to evaluate the clinical efficacy of single photon emission computer tompgraphy (SPECT) in combination with planar radioimmune and methylene-diphosphonate (MDP) - scintigraphic imaging of diabetic foot infection. The study group comprised 32 patients with type 1 and type 2 diabetes mellitus. All patients had diabetic foot ulceration with possible infection. All patients underwent clinical, bacteriological, X-ray and radioisotopic examination. Biochemical and instrumental investigation was carried out to estimate the degree of glycaemic control and available chronic diabetic complications. X-ray examination included radiographs centered on the foot lesion. All patients underwent bone scintigraphy with 370 MBq Technetium-99m-MDP (Tc-99m-MDP) three hours after injection in 3 projections (AP; LAO; RAO). Radioimmune planar imaging was performed by immunoscintigraphy with Tc-99m conjugated with monoclonal antigranulocyte antibody (MAB) BW 250/183. Immunoscintigraphy was performed 4 and 24 hours after administration of 740 MBq Tc-99m-MAB BW 250/183. In positive planar immunoscintigraphic cases and necessity of precise localization of inflammatory process - single photon emission computer tomography was performed. Final diagnosis - osteomyelitis was verified by bacteriological cultures and a long term follow up. Twenty two true positive cases, eight true negative cases, one false positive case, one false negative case were established. The sensitivity of the applied method for detection of osteomyelitis was 94 p.c., specificity 92 p.c., diagnostic accracy 93 p.c...


    172/2523

    Tytuł oryginału: Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit.
    Autorzy: Pak Jonathan T., Green John T., Heifets Boris, Pak Michelle H., Woodruff-Pak Diana S.
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR105-BR112, il., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • płeć żeńska

    Streszczenie angielskie: The cognition-enhancing drug, nefiracetam, is in Phase III clinical trials to treate memory impairment in Alzheimer's disease (AD). Nefiracetam ameliorates acquisition of delay eyeblink classical conditioning in older rabbits, a form of associative learning with striking behavioral and neurobiological similarities in rabbits and humans. In both species, delay eyeblink conditioning engages the septo-hippocampal cholinergic system and is disrupted when the cholinergic system is antagonized. Delay eyeblink classical conditioning is impaired in normal aging and severely disrupted in AD. To test further the efficacy of nefiracetam in an animal model that mimics some of the neurobiological and behavioral effects present in AD, we tested 56 older rabbits assigned to 7 treatment groups in the 750 ms delay eyeblink conditioning procedure. Older rabbits were injected with 1.5 mg/kg scopolamine to simulate disrutpion of the cholinergic system in AD. Three doses of nefiracetam (5, 10, or 15 mg/kg) were also injected in older rabbits receiving 1.5 mg/kg scopolamine. Control groups were treated with 1.5 mg/kg scopolamine + vehicle, wehicle alone, or explicitly unpaired presentations of conditioning stimuli and vehicle or 1.5 mg/kg scopolamine + 15 mg/kg nefiracetam. Rabbits injected with 1.5 mg/kg scopolamine alone were impaired, but a dose of 15 mg/kg nefiracetam reversed significantly the behavioral impairment. Nefiracetam had ameliorating effects on a task impaired in AD in an animal model of AD: older rabbits with cholinergic system antagonism.


    173/2523

    Tytuł oryginału: Percutaneous implantation of a biological valve in the aorta to treat aortic valve insufficiency - a sheep study.
    Autorzy: Boudjemline Younes, Bonnet Damien, Sidi Daniel, Bonhoeffer Philipp
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR113-BR116, il., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • chirurgia
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Historically, the surgical implantation of a mechanical valve in the descending aorta permitted the reduction of regurgitant flow in chronic aortic insufficiency. Long term clinical results were excellent but with the development of the pump oxygenators, orthotopic valvar replacement has become the conventional treatment of aortic valve diseases. We wanted to reconsider the ectopic position in sheep using a new percutaneous technique. A biological valve harvested from a bovine jugular vein was sutured into a vascular stent. After the creation of a severe aortic insufficiency, the valved stent was percutaneously implanted according to standard stent placement techniques. Hemodynamic and angiographic evaluations were carried out during the procedure; finally, anatomic evaluation was performed. A severe aortic insufficiency was created in all animals (9/9). 3 had a single stent in the descending aorta and 3 had an addtional stent in the brachiocephalic trunk. A control group of 3 animals had no valve implantation. One sheep had an additional valve implant because one overdilated stent had become insufficient. Early evaluation of the implanted valve function confirmed the perfect competence of 9 out of 10 valved stents. However, for unknown reasons all the animals died within 24 hours after the procedure. Percutaneously implanted valves in the thoracic aorta of sheep with massive aortic insufficiency function well in the acute study. In comparison to previous surgical results, this technique might become an alternative to surgery in patients with chronic aortic insufficiency in whom perioperative risks are high.


    174/2523

    Tytuł oryginału: Serodiagnostic and immunoprophylactic potential of a 78kDa protein of Leishmania donovani of Indian origin.
    Autorzy: Mukherjee Mandira, Bhattacharyya Anindita, Duttagupta Swadesh
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR117-BR122, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The serodiagnosis of visceral leishmaniasis due to Leishmania donovani using crude parasite antigen is complicated in many endemic areas by cross-reactions with serum from humans infected with other protozoan diseases. The search for pure antigens avoiding such cross-reactions is in progress. Developing a vaccine against cutaneous leishmaniasis has been much more successful than against visceral leishmaniasis. Immunoprophylactic studies using various combinations of antigens and adjuvants are also in progress, and several strategies are in use, with varying degrees of success. Promastigotes of Leishmania donovani were used. The 78kDa protein was purified by a monoclonal antibody tagged GNBr sepharose CL-4B column. The presence of the protein in both stages of the parasite and in kala-azar patient serum was analyzed by western blotting. ELISA was used for serodiagnosis and isotype analysis of antibodies produced in immunized mice. Immunoprophylactic studies were carried out based on in vitro transformation of amastigotes to promastigotes. The 78 kDa membrane protein, present in both amastigote and promastigote forms of the parasite, was purified to homogeneity. The protein was found to have serodiagnostic potential to detect kala-azar. BALB/c mice immunized with 78kDa protein revealed reduction in spleen parasitemia. Isotype profiles of antibodies produced by immunized mice showed increased production of IgG2a and decreased IgG levels. Our results demonstrated, for the first time, the serodiagnostic and immunoprophylactic use of a pure membrane protein isolated from Leishmania donovani of Indian origin...


    175/2523

    Tytuł oryginału: Functional maps of the junctions between interglobular contacts and active sites in glycolytic enzymes - a comparative analysis of the biochemical and structural data.
    Autorzy: Torshin Ivan Y.
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR123-BR135, il., tab., bibliogr. 47 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Oligomers and separate subunits of the glycolytic enzymes often have different catalytic properties. However, spectral data show an apparent lack of significant conformational changes during oligomerization. Since the conformation of an enzyme determines its catalytic properties, the structural mechanism(s) influencing the activity is of considerable interest. Analysis of the spatial structures of the junctions between interglobular contacts and binding sites may give a clue to the mechanism(s) of the activation. In this work, the problem was studied using available structural and biochemical data for the oligomeric enzymes of glycolysis. Computational analysis of the structures of the junctions has identified three structurally distinct types of junctions: 1. interglobular binding site (2 of 8 enzymes); 2. domain-domain stabilization (5 of 8); and 3. 'sequence overlap' or a local conformational change (all enzymes). Thus the catalytic activity may be influenced through the shifts of the modules of protein structure (types 1,2) and/or due to a slight change in the local structure (type 3). The more common junctions of types 2 and 3 are well conserved among eukaryotic enzymes, which suggests their biological importance. The results suggest that a profound and a complex change in conformation in subunits of an oligomeric enzyme may not be necessary for a significant change in the catalytic properties. The analysis maps the residues important for the junctions and thus for the link between the catalytic activity and the oligomeric state of the enzymes.


    176/2523

    Tytuł oryginału: Intracerebroventricular administration of bacterial lipopolysaccharide prevents the development of acute experimental pancreatitis in the rat.
    Autorzy: Jaworek Jolanta, Bonior Joanna, Nawrot Katarzyna, Leja Anna, Sendur Ryszard, Stachura Jerzy, Pawlik Wiesław, Konturek Stanisław
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR136-BR143, il., tab., bibliogr. 46 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Lipopolysaccharides (LPS) are responsible for septic shock but low doses of LPS reduce pancreatic damage produced by caerulein-induced pancreatitis (CIP) in rats. Leptin, produced by adipocytes attenuates the severity of CIP. The aim of this study was to evaluate the effect of intracerebroventricular (i.c.v) administration of LPS on CIP and plasma leptin level and to investigate the involvement of sensory nerves (SN) in the effects of LPS on CIP. CIP was produced by subcutaneous (s.c.) infusion of caerulein (25 ćg/kg) to conscious rats. SN were deactivated with capsaicin (100 mg/kg s.c.). LPS (0.2, 2, or 20 ćg/rat) were applied to the right cerebral ventricle 30 min prior to CIP. CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an antiinflammatory interleukin 10 (IL-10), (by 400 p.c., 1000 p.c., 700 p.c. and 50 p.c., respectively), confirmed by histological examination and accompanied by 40 p.c. reduction in pancreatic blood flow. Pretreatment of CIP rats with i.c.v. LPS resulted in significant reduction of CIP accompanied by dose-dependent increase in plasma levels of leptin and IL-10. Deactivation of SN, which by itself failed to affect CIP, completely reversed the beneficial effects of i.c.v. administration of LPS on CIP and reduced plasma leptin and IL-10 concentrations. Pretreatment with LPS given i.c.v. prevents the development of caerulein-induced pancreatitis through the activation of SN and though the release of leptin.


    177/2523

    Tytuł oryginału: Fibrinogen and smooth muscle cell detection in atherosclerotic plaques from stable and unstable angina - an immunohistochemical study.
    Autorzy: Loukas Marios, Dąbrowski Marek, Wagner Teresa, Walczak Ewa, Witkowski Andrzej, Rużyłło Witold
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR144-BR148, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: This study presents a systematic analysis of atherothrombotic lesions taken by percutaneous atherectomy and post mortem examination from coronary arteries, in order to identify: a) the topographic occurrence of fibrinogen and smooth muscle cells (SMCs), b) their independent expression in stable and unstable plaques, and c) their co-expression, which can provide a better understanding of the involvement of fibrinogen and SMCs in the development and progression of atherosclerotic plaques. Material/Methods: 120 specimens from atherosclerotic lesions were collected, using directional coronary atherectomy; 40 additional specimens were collected from postmortem examinations. All specimens were stained by immunohistochemical methods with monoclonal and polyclonal antibodies (DAKO) for fibrinogen and SMCs. Results: Fibrinogen appeared to be a component of all stable and unstable coronary atherosclerotic plaques, with a significant predominance in unstable angina. No significant difference was observed between SMC-stained areas in stable and unstable angina; however, a significant difference exists in co-expression of SMCs and fibrinogen between unstable and stable angina. Interestingly, the total number of SMCs at the first stages of formation of unstable plaques is less than in stable plaques. However, in a number of advanced coronary atherosclerotic plaques associated with unstable angina, we observed an increasingly progressive inflammatory cell activity, in which SMC areas were sifnigicantly increased...


    178/2523

    Tytuł oryginału: Effects of acute hypoxemia/ischemia on EEG and evoked responses at normothermia and hypothermia in humans.
    Autorzy: Stecker Mark M., Escherich Alison, Patterson Terry, Bavaria Joseph E., Cheung Albert T.
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR223-CR228, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hypothermia is used clinically to prevent neurologic injury but the degree of protection which it affords at various levels of the nervous system in humans is difficult to establish. Material/Methods: The temporal changes in EEG amplitude and somatosensory evoked potential (SEP) amplitudes in a patient experiencing acute normothermic hypoxemia, a patient experiencing acute circulatory arrest at moderate hypothermia and a collection of patients undergoing deep hypothermic circulatory arrest were analyzed to determine the rate at which changes occur during acute lack of oxygen delivery at various temperatures. Results: In each case, it was found that more rostrally geneated potentials disappeared more quickly than more peripheral potentials. All potentials decayed more slowly during acute normothermic hypoxemia than during circualtory arrest. During circulatory arrest at 14.4řC, the amplitude of the Erb's point, 13 and N18 potentials in th SEP took 5 times longer to drop to 50 p.c. of their value at the onset of ischemia than with circulatory arrest at 30.9řC. Conclusions: The longer times to disappearance of the SEP potentials during deep hypothermia compared to moderate hypotheramia was consistent with the predicted 3.5 - 6.5 fold reduction in metabolic activity at deep hypothermia compared to moderate hypothermia. The prolonged time to disappearance of the SEP during normothermic hypoxemia demonstrates that even with reduced oxygen delivery the continued delivery of metabolic substrate can be critical to neural function.


    179/2523

    Tytuł oryginału: Protocol for rapid sequence intubation in pediatric patients - a four-year study.
    Autorzy: Marvez-Valls Eduardo, Houry Debra, Ernst Amy A., Weiss Steven J., Killeen James
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR229-CR234, tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The purpose of the study was to evaluate a protocol for rapid sequence intubation (RSI) for pediatric patients in a Level 1 trauma center. Material/Methods: Retrospective review of prospectively gathered Continuing Quality Improvement (CQI) data at an inner city Level 1 trauma center with an emergency medicine residency program. Protocols for RSI were established prior toinitiating the study. All pediatric intubations at the center from February 1996 to February 2000 were included. Statistical analysis included descriptive statistics for categorical data and Chi-square for comparisons between groups. Results: Over the 4-year study period there were 83 pediatric intubations ranging in age from 18 months to 17 years; mean age 8.6. All had data collected at the time of intubation. There were 20 (24 p.c.) females and 62 (76 p.c.) males (p 0.001). Resons for intubation were related to trauma in 71 (86 p.c.) and medical reasons in 12 (14 p.c.) (p 0.001). Of the trauma intubations 7 (10 p.c.) were for gunshot wounds, 39 (55 p.c.) were secondary to MVCs, and the remainder (25; 35 p.c.) were from assaults, falls, and closed head injuries. The non-trauma intubations were for smoke inhalation, overdose, seizure, HIV related complications, eclapsia, and near drowning. Intubations were successful with one attempt in 65 (78 p.c.) cases. No surgical airways were necessary. Rocuronium was used in 4 cases. Protocol deviations did not lead to complications. Conclusions: This protocol based pediatric rapid sequence intubation method worked well in an EM residency program. More intubations were in males and more were necessary due to trauma in this group.


    180/2523

    Tytuł oryginału: Side clamp used during off-pump coronary artery bypass does not increase the risk of stroke.
    Autorzy: Hirose Hitoshi, Amano Atsushi, Takahashi Akihito
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR235-CR240, tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of this study was to investigate whether the incidence of stroke after off-pump AC bypass was lower than that after on-pump AC bypass. Material/Methods: A prospective study was performed with consecutive patients who underwent isolated AC bypass in the Shin-Tokyo Hospital Group between July 1, 1996 and December 31, 2001 AC bypass was defined as coronary artery bypass requiring proximal anastomoses onto the ascending aorta. The patietns were divided into two groups, depending on the use of cardiopulmonary bypass: on-pump and off-pump groups. Perioperative data were prospectively collected and the risk factors for postoperative stroke were investigated. Resutls: Preoperative comorbidiites were more frequent in the off-pump group. The number of distal anastomoses was not significantly different but the number of proximal anastomoses was significantly greater in the on-pump group than in the off-pump group. The incidence of postoperative stroke was 0.3 p.c. in the off-pump group and 2.0 p.c. in teh on-pump group. Significant risk factors influencing the occurrence of postoperative stroke included: use of cardiopulmonary bypass, age over 75, peripheral vascular disease, saphenous vein use, and postoperative atrial fibrillation. Multivariate analysis demonstrated that the use of cardiopulmonary bypass, age over 75, and peripheral vascular disease were isolated predictors of postoperative stroke. Conclusions: The incidence of postoperative stroke was lower in the off-pump group than in the on-pump group, even though the side clamp was applied to the ascending aorta for aortocoronary bypass. The use of side clamping for off-pump AC bypass does not increase the risk of postoperative stroke.


    181/2523

    Tytuł oryginału: Predictors of mortality among nursing home residents with a diagnosis of Parkinson's disease.
    Autorzy: Fernandez Hubert H., Lapane Kate L.
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR241-CR246, tab., bibliogr. 63 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Little is konwn about predictors of mortality among Parkinson patients living in long term care. Material/Methods: We conducted a 3-year follow-up study on 15,237 PD residents aged 65 years and older using the Systematic Assessment in Geriatric drug use via Epidemiolgoy (SAGE) database. The SAGE database consists of the Minimum Data Set (MDS) data collected on over 400,000 nursing home residents in 5 U.S. states, including demographic characteristics, demntia severity, comorbidity and other clinical variables. Information on death was derived through linkage to Medicare files. Baseline characteristics were used to predict survival using univariate and multivariate Cox proportional hazard models. Results: The overall 3-year mortality rate was 50 p.c. Advanced age (relative rate (RR) 2.22; 95 p.c. confidence interval (CI) 1.99 - 2.47, for patients 85+ years), male gender (RR 1.73; 95 p.c. CI 1.60 - 1.87), severe functional (RR 1.81; 95 p.c. CI 1.53 - 2.13) and cognitive (RR 1.54; 95 p.c. CI 1.38 - 1.72) impairment, the presence of vision problems (RR 1.25; 95 p.c. CI 1.20 - 1.57), pressure ulcers (RR 1.25; 95 p.c. 1.14 - 1.37), and a diagnosis of congestive heart failure (RR 1.49; 95 p.c. CI 1.35 - 1.65), diabetes mellitus (RR 1.22; 95 p.c. 1.11 - 1.35) and pneumonia (RR 1.39; 95 p.c. CI 1.09 - 1.77) were independent predictors of death. The specific presence of aspiration pneumonia had the highest mortality risk ratio among all comorbidities (RR 1.58; CI 0.97 - 2.56). Africa-Americans and other minority groups were less likely to die relative to whith PD residents...


    182/2523

    Tytuł oryginału: Causes for early reintervention after thyroidectomy.
    Autorzy: Hurtado-López Luis Mauricio, Zaldivar-Ramirez Felipe Rafael, Kuba Erich Basurto, Cejudo Abraham Pulido, Flores Jose Humberto Garza, Solis Oscar Muńoz, Castillo Carlos Campos
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR247-CR250, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our study was to ascertain the causes for early reintervention after thyroidectomy performed by a surgical team using a systematized surgical technique. Material/Methods: We analyzed 1131 patietns, 939 (83.1 p.c.) women and 192 (16.9 p.c.) men, average age 38.7 years (range 12 to 79). Of these patients, there were 675 hemithyroidectomies with isthmusectomy (59.74 p.c.), 189 subtotal thyroidectomies (16.71 p.c.), and 267 total thyoidectomies, alone or with regional lymphatic dissection at levels VI and VII (23.55 p.c.). Statistical analysis was performed by main tendency measures and chi square (chi-squared) for comparison of two independent samples; the dependent variable was the rate of early reintervention, while the independent variables included causes, time of presentation, hormonal functional state and extent of surgery. Results: Early reintervention was necessary in 11 cases (0.97 p.c.). 9 were due to hematoma (0.79 p.c.) resolved with drainage and hemostasis, and two (0.18 p.c.) due to acute respiratory failure (ARF) caused by laryngeal edema, resolved by tracheostomy. Analysis based on diagnosis, extent of surgery and functional state failed to reveal statistically significant differences. The maximum time presentation of complications was 6 hours. Conclusions: The most intense postoperative monitoring is necessary during the first six hours. The low frequency of early reintervention and the appearance of complications in less than 8 hours enable thyroid surgery to be performed on a short-stay basis with adequate safety margins.


    183/2523

    Tytuł oryginału: Characteristics and outcome among women and men transported by ambulance due to symptoms arousing suspicion of acute coronary syndrome.
    Autorzy: Herlitz Johan, Starke Mia, Hansson Elisabeth, Ringvall Eva, Karlson Bj”rn W., Waagstein Lisbeth
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR251-CR256, tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of this study was to describe the characteristics and outcome in relation to sex in consecutive patients who were transported by an ambulance due to symptoms arousing suspicion of acute coronary syndrome. Materia/Methods: Our reserach involved all patietns transported by ambulance over a 3-month period in the community of G”teborg due to such symptoms. The P-values were age adjusted. Results: Of the 930 transported patietns fulfilling the given criteria, 452 (49 p.c.) were of women. The women were older and had a lower incidence of previous acute myocardial infarction, angina pectoris, and current smoking. Women less frequently had a final diagnosis of acute coronary syndrome (22.3 p.c vs 36.6 p.c.; p 0.0001) or acute myocardial infarction (10.1 p.c. vs 17.9 p.c.; p 0.0001). However, the mortality rate during one year was the same in women (17.2 p.c.) and men (18.7 p.c.). Women were less frequently clammy on admission to the ambulance (17 p.c. vs 30 p.c.; p 0.0001) and less frequently showed signs of myocardial ischemia in ECG upon admission to the emergency department (26 p.c. vs 38 p.c.; p 0.001) compared to men. Among those patietns with an acute coronary syndrome, women more frequently complained of dyspnea than men (27 p.c. vs 12 p.c.; p = 0.018). Conclusion: Our study suggests that among ambulance transported patients with suspicion of acute coronary syndrome there are some differences between women and men in terms of their characteristics and underlying etiology, but not in terms of the risk of mortality.


    184/2523

    Tytuł oryginału: A multi-center open study to determine the effect of lamivudine on HBV DNA clearance and to assess the safety of the regimen in patietns with chronic hepatitis B infection.
    Autorzy: Mazur Włodzimierz, Król Franciszek, Cianciara Janusz, Nazzal Khalil, Gładysz Andrzej, Juszczyk Jacek, Bolewska Beata, Adamek Jacek, Czajka Barbara, Świętek Katarzyna, Kryczka Wiesław, Gonciarz Zbigniew
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR257-CR262, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Patietns with on-going HBV viral replication often present with clinical features of active chronic hepatitis. Until the recent introduction of nucleoside analogues, interferon-alpha was the only approved drug for these patietns. One of the former drugs, lamivudine, has been shown in clinical trials in the US and Asia to effectively inhibit the viral polymerase of HBV. Our study was undertaken to assess the efficacy and safety of lamivudine therapy in Polish patietns with chronic hepatitis B. Material/Methods: Forty-five patients with chronic hepatitis B (HBeAg positive, anti-e negative, HBV-DNA positive by hybridization assay) were enrolled in the study. The patietns received 100 mg of lamivudine orally, once daily for 12 months. They returned for routine clinical and laboratory control every two weeks during the first months of treatment, and later at 3-month intervals whle receiving lamivudine. Results: At the end of treatment, serum HBeAg was not detected in 21 patients (48.8 p.c.), and anti-HBe appeared in the serum of 19 patients. 37.2 p.c. of the patietns in the study group showed sustained suppression of serum HBV DNA at the end of treatment. Lamivudine therapy was well tolerated, with the rate of occurrence of adverse events similar to that observed in other clincial studies. Conclusions: 12-month lamivudine therapy in this Polish population of patients with chronic hepatitis B induced a high rate of HBeAg seroconversion, accompaneid by reduction of HBV-DNA and the normalization of alanine aminotransferase activities.


    185/2523

    Tytuł oryginału: Level of antithrombin III, protein C, protein S and other selected parameters of coagulation and fibrinolysis in the blood of the patietns with recurrent deep venous thrombosis.
    Autorzy: Świątkiewicz Andrzej, Jurkowski Piotr, Kotschy Maria, Ciecierski Marek, Jawień Arkadiusz
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR263-CR268, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Thrombophilia is caused mainly by disturbances of hemostasis involving excessive coagulation system activation, reduction of anticoagulation system (antithrombin III, protien C, protien S, RAPC) or fibrinolytic activity. Material/Methods: In 34 young patietns (aged 40 years) with recurrent deep venous thrombosis ( 2 incidents) the activity of antithrombin III, protien C, S, platelet count, adhesion and aggregation, APTT, stipven-kephalin, prothrombin time and INR were investigated. Fibrinogen, factor XIII, ELT, FDP, Ag t-PA levels, antigen concentration and PAI-1 activity were determined. Patietns with idiopathic DVT, after elimination of most important thromboembolism risk factors, were qualified for the study. DVT was confirmed in all patients by phlebography, plethysmography and ultrasonography. Results were compared with a group of 54 healthy controls. Results: In almost 50 p.c. of patients with recurrent DVT (15/34) decrease of at least one plasma coagluation inhibitor (AT III, PC, PS) level was observed. In the patient group (with AT III and/or PC and/or PS decrease) statistically significant reduction of kaolin-kephalin time in comparison with controls was observed (ŕ 0.01). Analysis of fibrinolysis system demosntrated significant factor XIII level decrease (to 58.3 p.c.), fibrinogen level increase, ELT prolongation, and fibrinogen and fibrin degradation product increase in comparison with controls. THe patients demonstrated 3-fold higher t-PA antigen level (13.1 ng/ml, ŕ 0.0001) and over 3-fold higher PAI-1 activity (26.7 AU/ml, ŕ 0.001) than healthy controls...


    186/2523

    Tytuł oryginału: Assessment of iron metabolism in children with chronic hepatitis B - prognostic factor in interferon alpha therapy.
    Autorzy: Chrobot Andrzej, Chrobot Agnieszka Monika, Szaflarska-Szczepanik Anna
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR269-CR273, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to assess iron metabolism in children with chronic hepatitis B and to establish whether it had any influence on the results of interferon alpha therapy. Material/Methods: The study was carried out in a group of 38 children aged from 2 to 16 years with chronic hepatitis B diagnosed according to serological, biochemical and histopathological criteria. All the patietns were treated according to the commonly adopted schedule: interferon alpha administered subcutaneously three times a week at 3 MIU doses for 20 weeks. During the therapy and one-year follow-up after its completion, biochemical liver function parameters, serological HBV markers, and iron and ferritin levels were monitored. Results: The therapy resulted in obtaining seroconversion in the HBe system in 9 patients (23.68 p.c.). Liver bioptates in that group of patients demonstrated more advanced changes due to inflammatory activity and fibrosis processes, significantly higher values of alanine aminotransferase, lower serum levels of iron and ferritin with more pronounced difference in ferritin levels, although the differences reached no statistical significance. Conclusions: No disturbances of iron metabolism were observed in children with chronic hepatitis B. In the group of patietns with detectable seroconversion in the Hbe system resulting from interferon alpha therapy, lower serum levels of iron and ferritin were observed. Reoutine determinations of serum iron and ferritin levels as a prognostic factor for positive response to interferon alpha seem to be of little use, especially in children, in whom no iron accumulation in liver tissue is observed in histopathological assessment of liver bioptates.


    187/2523

    Tytuł oryginału: Course of viral hepatitis B and combined B and C hepatitis in children treated for neoplastic diseases.
    Autorzy: Kołtan Sylwia, Wysocki Mariusz, Kołtan Andrzej, Świątkiewicz Violetta, Styczyński Jan, Dębski Robert, Balcar-Boroń Anna
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR274-CR279, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • toksykologia
  • mikrobiologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Viral hepatitis C in children is milder than in adults. Patients with tumors, because of immune deficits, seem to be at risk of rapid liver disease progression. Little is known about the course of HCV and dual HBV-HCV infections in such patients. Material/Methods: The study assessed clinical courses of HCV and dual HBV-HCV infections in 249 children with tumors aged 1-18 years, divided into four groups: with HCV infection - 53, HBV-HCV infection - 53, HBV only - 33 and ifection-free - 110. Results: Hepatitis C was often chronic - in 83.3 p.c of patients with HCV and 77.3 p.c. of those with dual infection. Over 80 p.c. had no jaundice. Mean AIAT activity was the highest in the HCV group (149.2 ń 202.7 IU/l), lower in the dual infection group (123.3 ń 148.1 IU/l; p 0.02), and the lowest in HBV (92.7 152.9 IU/l. Transaminasemia course in patients with HCV and dual HBV-HCV infections was most frequently fluctuating (50.9 p.c. and 45.3 p.c., respectively). 52.8 p.c. of children with HCV demonstrated no advanced inflammatory lesions with invasion of the lamina limitans, no marked fibrosis, and minimum changes in descriptive classification. In 92.3 p.c. of children with dual infections, inflammatory activity was mild or mean, with no fibrosis in 61.5 p.c., and persistnet chronic inflammation predominant in descriptive classification (46.2 p.c.). Conclusions: HCV an HBV-HCV infections in children with neoplastic diseases tend to take chronic forms, but their clinical course is mild with signs of severeinflammatory activity or hepatitic strom aremodeling observed on histopathology.


    188/2523

    Tytuł oryginału: Total IgE levels and skin test results in children under three years of age with food hypersensitivity.
    Autorzy: Malinowska Elżbieta, Kaczmarski Maciej, Wasilewska Jolanta
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR280-CR287, il., tab., bibliogr. 43 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The most common tools of allergologic diagnostics are skin prick tests (SPT) and total serum IgE (IgE total) determinations. Material/Methods: The study was carried out in a group of 348 children aged 5 to 36 months. All the children underwent SPT using 12 food allergens and in 229 of them also 9 inhalant allergens were tested. Assessment of test positivity utilized relative criteria, i.e. the result was regarded as positive if a wheal with S surface area exceeding or equal to 0.25 of the surface area SO of a control wheal was formed. In this study group, 291 had IgE total levels determined. They were divided into the groups with elevated and normal IgE total levels on the basis of two standards, i.e. the standards recommended by the manufacturer of the test reagents used to determine IgE total (BioWhittaker) and the population standards. Resutls: Positive SPT results for food allergens were obtained in 15.8 p.c. of the examined children, for inhalant ones in 21.8 p.c. The factors taken into account in the analysis of impact on SPT results included age, sex, living place and the use diet. Elevated IgE total levels according to the manufacturer's standards were detected in 35.0 p.c., and according to the population standards in 67.0 p.c. of the examined children. The obtained positive test results were compared with elevated IgE total in the studied patients.Conclusions: 1. Feasibility of SPT at this age. 2. Determination of normal IgE total range in the group of children below three requires further studies.


    189/2523

    Tytuł oryginału: Salt iodination as a effective method of iodine supplementation.
    Autorzy: Grzesiuk Wiesław, Kondracka Agnieszka, Słoń Milena, Wojda Marzena, Nauman Janusz
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR288-CR291, il., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In January 1997 a new approach to preventing iodine deficiency was introduced in Poland. The goal of the present study was to determine whether the mandatory iodization of kitchen salt (30 mg KI/kg) has had any impact on ioduria. Material/Methods: The study was performed on 29 healthy volunteers, aged 22-29 (average age 23.93 ń 1.14), examined in 1996 and retested after 36 months of iodine supplementation in 1999. Each person underwent a physical examination and thyroid ultrasonography. The iodine level was determined using morning urine samples. Results: For the duration of the study thyroid volume remained unchanged, ranging from 11.48 ń 3.89 ml in 1996 to 12.11 ń 3.85 ml in 1998. THe echostructure was normal in all subjects both in 1996 and in 1999. In 1996 the iodine concentration in urine (ICU) in the study group averaged 100.4 ń 41.5 ćg/L (range from 43.3 to 175.6 ćg/L). Seventeen persons had an iodine cncentration below 100 ćg/L. In 1999 the average ICU was 140.7 ń 78.87 ćg/L. Three subjects had a lower ICU in 1999 (53.93 ń 24.65 ćg/L) than in 1996 (104.1 ń 24.6 ćg/L). These persons claimed to have completely eliminated the use of added salt in their diet. Conclusion: We conclude that mandatory iodine supplementation method is sufficiently effective when salt is used in the diet. In the case of restrictions on salt consumption the use of preparations containing iodine should be recommended.


    190/2523

    Tytuł oryginału: Drug-induced liver damage - a three-year study of patients from one gastroenterological department.
    Autorzy: Hartleb Marek, Biernat Łukasz, Kochel Anna
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR292-CR296, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bakcground: The aim of our study was to analyze drug-induced liver disease over a 3-year period in one gastroenterological department. Material/Methods: International consensus standard definitions and criteria for assessing causality of adverse drug reactions were applied to all patients with abnormal hepatic test results. Results: Drugs were implicated in hepatic injury in 14 patietns (8 females) in whom causal relationship between drug and liver disease was definite or highly probable. The drugs responsible were amoxicillin with clavulanic acid (3 cases), fluvastatin and pravastatin (3 cases), antituberculous drugs (2 cases), estrogens, roxithromycin, asacol, satolol, enalapril and thiamazol. A total of 78.6 p.c. (11 cases) were classified as hepatocellular or mixed hepatitis, while cholestatic injury was found in 21.4 p.c. (3 cases). There were no lethal or severe (prothrombin 50 p.c.) hepatic drug reactions. In 13 patietns the course of liver disease after with drawal of the offensive drug was either acute or protracted, while in one patient there was chronic cholestasis ( 3 years) resulting from injury to interlobular bile ducts by amoxicllin with clavulanic acid. Conclusion: A thorough history of drug intake should be taken in all patients presenting with abnormal hepatic test results. Amoxicillin & clavulanic acid, cholesterol-lowering and antituberculin drugs were the most frequent hepatotoxic factors in our patients. In a majority of cases the liver injury was not severe, and resolved after prompt withdrawal of the responsible drug.


    191/2523

    Tytuł oryginału: Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma - a double-blind randomized placebo-controlled multicentre clinical trial.
    Autorzy: Goldstein Marc F., Chervinsky Paul
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR297-CR304, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Experimental studies have shown that doxofylline is endowed with a remarkable bronchodilator activity with less extra-respiratory effects than theophylline. This trail was designed to compare the efficacy and safety of doxofylline, theophylline, and placebo in patients with chronic reversible bronchial asthma. Material/Methods: Three hundred forty-six patietns were randomly assigned to a 12-week oral treatment with either doxofylline 400 mg t.i.d. (high dose), doxofylline 200 mg t.i.d. (low dose), theophylline 250 mg t.i.d. (active control) or placebo. Pulmonary function tests (PFTs) were performed biweekly. Patients kept records of peak flow meter (PFM) measurements, asthma attack rate and beta-2-agonist use (albuterol). Results: Changes in FEV1 2 hours after the administration of treatments versus baseline exhibited statistically significant differences between doxofylline 400 mg t.i.d. and placebo and between theophylline and placebo. Similar differences were monitored on the other variables (FVC, PFER, FEF25-75 p.c. Asthma attack rate and use of albuterol decreased remarkably with doxofylline 400 mg t.i.d. and theophylline. There were few statistically significant differences between doxofylline 200 mg t.i.d. and placebo. Significantly more patients had to interrupt treatment because of adverse events under theophylline than under doxofylline 400 mg t.i.d. (p=0.001). With doxofylline 400 mg t.i.d., the number of patietns treated to spare one dropout due to theophylline was 5. Conslusion: This study provides evidence that doxofylline 400 mg t.i.d. is an effective treatment for relieving airway obstruction and displays a better safety profile with respect to theophylline 250 mg t.i.d. with a favorable risk-to-benefit ratio.


    192/2523

    Tytuł oryginału: Comorbid disease profiles of adults with end-stage hip osteoarthritis.
    Autorzy: Marks Ray, Allegrante John P.
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR305-CR309, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Although hip osteoarthritis is a common disabling condition, an incomplete understanding of all factors that contribute to hip osteoarthritis disability persists. The objective of the study was to improve our understanding of potentially preventable factors that might influence hip osteoarthritis disability by examining the prevalence and impact of selected comorbid factors potentially associated with the progression and severity of hip joint osteoarthritis among patietns with end-stage hip osteoarthritis. Material/Methods: The mdical records of 1,000 hip osteoarthritis surgical patients were assessed to specifically identify the presence or absence of comorbid conditions of the cardiac, vascular or respiratory systems. The assocaition between the patient's functional status before and after surgery, and the presence or absence of these comorbid conditions, was assessed. Results: Over 55 p.c. of the sample had at least one comorbid condition, such as hypertension or cardiac disease. After controlling for age, trauma, type of surgery and gender discrepancies, those with two or more comorbidities were found to have greater degrees of functional impairment before surgery, and lower post-operative functional status after surgery than those with no coexistent disease (P 0.05). Conclusion: Patietns with end-stage hip osteoarthritis exhibit a high prevalence of vascualr-related comorbidities. THe disability of patients with hip osteoarthritis is increased in the presence of two or more related comorbid conditions. These findings suggest a novel focus for primary, secondary and tertiary preventive strategies.


    193/2523

    Tytuł oryginału: Combination of pamidronate and thalidomide in the therapy of treatment-resistant multiple myeloma.
    Autorzy: Ciepłuch Hanna, Baran Wojciech, Hellmann Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.PI31-PI36, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • toksykologia
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Bisphosphonates inhibit the activity of osteoclasts and demonstrate antitumor effect, involving induction of plasmocyte apoptosis, blocking of angiogenesis, stimulation of Tçë lymphocytes and inhibition of metalloproteinases. Bisphosphonates combined with thalidomide, a drug possessing confirmed anti-myeloma activity, seem to have potential favorable effect in patietns with treatment-resistant multiple myeloma with advanced osteolytic lesions. Material/Methods: 13 patietns with treatment-resistant multiple myeloma with advanced osteolytic lesions received combined pamidronate and thalidomide therapy. All the patietns underwent detailed clinical and laboratory control once a month. Pamidronate was used at 90 mg iv dose administered at 4-week intervals, and thalidomide at doses escalated from 200 mg/d in the first week to 400 mg/d after 3 weeks of the therapy. The mean duration of treatment was 12 weeks with a range of 3 to 36 weeks. Results: 7 patietns (53 p.c.) receiving pamidronate and thalidomide therapy demonstrated good response involving at lesast 25 pc. reduction of monoclonal protein levels in comparison with baseline. All these patietns reported improvement of osteodynia symptoms, and 3 of them - thier complete regression. 70 p.c. patients experienced side effects (dizziness, constipation, somnolence, polyneuropathy) due to thalidomide administration. Conclusion: Good response to combined pamidroante and thalidomide therapy can be expected in at least 50 p.c. of patietns with treatment-resistant multiple myeloma with advanced osteolytic lesions.


    194/2523

    Tytuł oryginału: Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.
    Autorzy: Rajtar Grażyna, Żółkowska Dorota, Kleinrok Zdzisław
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.PI37-PI44, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Benzodiazepine binding sites distnict from the GABA-receptor-chloride-complex in the central nervous system have been recongized in many peripheral tissues, but their physiological role remains unexplained. Our study was undertaken to examine the effects of diazepam, clonazepam, and PK 11195, a peripheral benzodiazepine receptor antagonist, on the functional and biochemical responses of platelets and neutrophils stimulated by different physiological agonists. Material/Methods: The experiments were conducted on isolated washed rat platelets activated by arachidonic acid (AA), adenosine 5'-diphosphate (ADP), or thrombin and on isolated rat neutrophils activated by a chemotactic peptide, formyl methionyl leucyl phenylalanine (fMLP). Results: The results showed that neither diazepam nor clonazepam nor PK 11195 alone augmented the reponse of resting platelets or modified neutrophil reponse, but diazepam and clonazepam in a concentration-dependent manner inhibited thrombin, ADP or AA-stimulated platelet aggregation and the thrombin-induced increase in free intracellular Caý+. Both drugs also exerted an inhibitory effect on reactive oxygen species (ROS) produced by fMLP-stimulated neutrophils. However, diazepam was about 10 times more effective than clonazepam. PK11195 did not influence platelet and neutrophil function stimulated by agonists, but reversed the inhibitory action of both benzodiazepines on platelet activation and ROS production. Conclusions: The results indicated that invitro diazepam, and in a much smaller degree clonazepam, may down-regulate platelet activation and release of some proinflammatory mediators by stimulated neutrophils. These effects are probably exerted by a specific benzodiazepine binding sites.


    195/2523

    Tytuł oryginału: Rehabilitation outcome in a patient awakened from prolonged coma.
    Autorzy: Talar Jan
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CS31-CS38, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: This article describes the rehabilitation of a patient recovering from a prolonged coma (defined as lasting longer than 4 weeks). The case is noteworthy because it exemplifies the possibilities and difficulties entailed in treating these patients, who are often regarded as too severely impaired to justify intensive rehabilitation efforts. Case report: The patietn is a 28-year old Polish male, unmarried, who suffered serious closed head injuries in an automobile accident in April of 1999. He was in a comatose state for more than two months, with a GCS score of 5. When admitted for rehabilitation he was bedriedden, wht global aphasia, agraphia, limb apraxia, and executive dysfunction. THe rehabilitation program developed for him is described in detail. Results: Over the course of rehabilitation, which began in December 1999 and continues to this writing, the patient has regained locomotion capabilities (though with impairments), and his speech has improved considerably. The apraxia has largely resolved, and he is able to write his name and copy words. he is now capable of performing many activities of daily living. Conclusions: A comprehensive program of rehabilitation characterized by a strategic, heurisitic approach is capable of achieving a good outcome even in very difficult cases, such as prolonged coma.


    196/2523

    Tytuł oryginału: Non-valvular isolated pulmonary artery vegetations.
    Autorzy: Farsak Bora, Yilmaz Mustafa, ™c Mehmet, ™zkutlu Sheyla, Demircin Metin
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.CS39-CS41, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • płeć męska

    Streszczenie angielskie: Background: One of the serious potential complications of complex congenital heart defect (CHD) is bacterial endocarditis. Right sided endocarditis accounts for 5-10 p.c. of all cases of infective endocarditis, with the tricuspid valve more frequentlly affected than the pulmonary valve. Pulmonary artery involvement in bacterial endocarditis is very rare, but when it exists it is almost always associated with endocarditis of the pulmonary valve: isolated pulmonary artery vegetations have not previously been reported before. Case Report: A 6-year-old boy with atrial septal defect (ASD), ventricular septal defect (VSD), coarctation of the aorta (CA), persistent ductus arteriosus (PDA) and pulmonary hypertension, who had been operated for closure of PDA, correction of CA and pulmonary artery banding, was readmitted with bacterial endocarditis. In surgery, the VSD was closed with a Dacron patch using interrupted pledget buttressed sutures, and the ASD was closed using primary sutures. After debanding, while pulmonary arteriotomy was performed for patch angioplasty, we observed that the entire pulmonary artery trunk, right and left pulmnary artery branches, were filled with a solid mass, which was successfully treated by surgical excision. Conclusion: With ongoing improvements in diagnostic tools, especially in echocardiography, antibiotic therapy and surgery, CHD can now be treated successfully in early infancy or childhood.


    197/2523

    Tytuł oryginału: Dynamic magnetic resonance imaging in soft tissue tumors - assessment of the diagnostic value of tumor enhancement rate indices.
    Autorzy: Tacikowska Małgorzata
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.MT53-MT57, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: Dynamic MRI is routinely used in the diagnosis of soft tissue tumors to supplement static imaging. The aim of our study was to assess the diagnostic value of dynamic MRI using the coefficient of total tumor enhancement expressed as per cent (tec p.c.) and the tumor enhancement rate coefficient expressed as per cent per minute (erc p.c./min), and to make a comparative analysis of the sensitivity and specificity of both parameters. Material/Methods: The material consisted of 45 patietns (30 sarcomas, 15 non-malignant lesions). The age of the pateitns was 16-64 years. The MRI was done using an Elscint 2T unit, applying gradient echo techniques. The coefficient of total contrast enhancement (tec p.c.) and the tissue enhancement rate (erc p.c./min) were calcuatated. The limit values were determined for dividing the tumors into sarcomas and non-malignant lesions. The sensitivity and specificity of MRI were calculated and compared using both indices. Results: Dynamic MRI with calculation of erc p.c./min and tec p.c. makes it possible to differentiate between sarcomas and non-malignant lesions. Conclusions: The erc p.c./min was a more sensitivie than tec p.c. differentiating parameter in the diagnosis of soft tissue tumors.


    198/2523

    Tytuł oryginału: A radical approach to cancer.
    Autorzy: Das Undurti N.
    Źródło: Med. Sci. Monitor 2002: 8 (4) s.RA79-RA92, il., bibliogr. 173 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Reactive oxygen species are known to be potentially dangerous, but are also needed for signal-transduction pathways. Tumor cells have relatively low amounts of superoxide dismutase (SOD), which quenches superoxide anion (o2) and as a result of a higher level of aerobic metabolism, higher concentrations of O2, compared to normal cells. But this may not be true of all tumor cells. Some tumor cells have relatively higher amounts of vitamin E, a potent antioxidant, and a higher level of anaerobic metabolism, resulting in a balance that is tilted more towards higher anti-oxidant capacity. In both instances of higher aerobic and anaerobic metabolism methods designed to augment free radical generation in tumor cells can cause their death. It is suggested that free radicals and lipid peroxides suppress the expression of Bcl-2, activate caspases and shorten telomere, and thus inducing apoptosis of tumor cells. Ionizing radiation, anthracyclines, bleomycin and cytokines produce free radicals and thus are useful as anti-cancer agents. But they also produce many side-effects. 2-methyoxyoestradiol and polyunsaturated fatty acids (PUFAs) inhibit SODs and cause an increase of O2 in tumor cells leading to their death. In addition, PUFAs (especially gamma-linolenic acid), 2-methoxyoestradiol and thalidomide may possess anti-angiogenic activity. This suggests that free radiocals can suppress angiogenesis. Limited clinical studies done with gamma-linolenic acid showed that it can regress human brain gliomas without any signficant side-effects. Thus, PUFAs, thalidomide and 2-methoxyoestradiol or their derivatives may offer a new radical approach to the treatment of cancer.


    199/2523

    Tytuł oryginału: Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats.
    Autorzy: Mikołajczak Przemysław, Okulicz-Kozaryn Irena, Kamińska Ewa, Niedopad Lidia, Polańska Anna, Gębka Joanna
    Źródło: Eur. J. Pharmacol. 2002: 444 (1/2) s.83-96, il., tab., bibliogr. s. 94-96
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The aim of this study was to evaluate the effect of multiple acamprosate (500.0 mg/kg, p.o.) administration on short-term memory, using te social recognition test in rats. Ifenprodil (1.0 mg/kg, i.p.), arcaine (5.0 mg/kg, i.p.) and spermidine (20.0 mg/kg, i.p.) were chosen as polyamine ligands and their action or interaction with acamprosate was also studied. The doses used did not show any sedative activity, which was assessed by measuring locomotor activity and the hypnotic effect of ethanol. The findings suggest that acute acamprosate treatment did not impair short-term memory. Multiple acamprosate and a single spermidine or arcaine administration led to better performance in the memory test, whereas no significant difference was observed in ifenprodil-treated rats. Co-administratio of a single arcaine or spermidine dose with multiple acamprosate produced worse results. This means that the effect of repeated acamprosate administration can be changed by the co-administration of other polyamine ligands, so that care should be taken in interpreting.


    200/2523

    Tytuł oryginału: Repeated imipramine and electroconvulsive shock increase ŕ1A-adrenoceptor mRNA level in rat prefrontal cortex.
    Autorzy: Nalepa Irena, Kreiner Grzegorz, Kowalska Marta, Sanak Marek, Zelek-Molik Agnieszka, Vetulani Jerzy
    Źródło: Eur. J. Pharmacol. 2002: 444 (3) s.151-159, il., tab., bibliogr. s. 158-159
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: ŕ1-Adrenoceptors have been implicated in the mechanism of action of antidepressants, but their action on specific receptor subtypes was rarely reported. We compared now the action of two prototypic antidepressant treatments: repeated imipramine and electroconvulsive shock, on the expression of the ŕ1A - and ŕ1B -adrenoceptor mRNAs and on the receptor density in rats. The mRNA expression was assessed by Northern blot in the prefrontal cortex and the hippocampus, the receptor density was measured by [3H] prazosin binding in the total cerbral cortex and hippocampus. In the cortex, both treatments elevated the ŕ1A -adrenoceptor mRNA and the expression of receptor protein. The expression of ŕ1B -adrenoceptor mRNA remained unaffected. In contrast, in the hippocampus, the antidepressant treatments augmented the density of ŕ1A -adrenoceptor protein without changing the level of its mRNA expression there. The results suggest that the ŕ1A -adrenoceptor subtype is specifically involved in the mechanism of action of classical antidepressant treatments.


    201/2523

    Tytuł oryginału: Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer.
    Autorzy: Przybyłowska K., Smolarczyk K., Kulig A., Romanowicz-Makowska H., Dziki A., Ulańska J., Pander B., Błasiak J.
    Źródło: Cancer Lett. 2002: 181 (1) s.23-30, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 306,023

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia
  • genetyka
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We analysed the distribution of genotypes of two polymorphisms in the urokinas-type plasminogen activator (uPA) gene: C - T substitution in exon 6 and T - C substitution in intron 7 in 52 subjects with colorectal cancer. Genotypes were determined in tumour tissue and distant mucosa samples by allele-specific polymerase chain reaction. The antigen levels of uPA in cancer tissue were higher than in distant mucosa as measrued by enzyme-linked immunosorbent assay. The level of uPA antigens in cancer samples with the C/C genotype of C - T polymorphism in exon 6 was higher than in samples with C/T and T/T genotypes. No differences in the level of uPA antigens between the alleles of the intron 7 T - C polymorphism were found. As uPA can be involved in cancer invasion and metastasis, C/C genotype in exon 6 of uPA gene can be further considered as being related to colorectal cancer progression.


    202/2523

    Tytuł oryginału: Hemodynamic performance after stented vs stentless aortic valve replacement.
    Autorzy: Jasiński M. J., Hayton J., Kadziola Z., Woś S[tanisław], Sosnowski A. W.
    Źródło: J. Cardiovasc. Surg. 2002: 43 (3) s.313-317, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 311,845

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background. Stentless bioprostheses are anticipated to cause improved hemodyanmics and increased longevity over stented bioprosthesis. We have compared echocardiographic analysis of stented bioprosthesis "Freestyle" with stented "Mosaic" bioprosthesis. Because of similar technology (0 pressure fixation, anticalcification) any differences may relate to stent. Methods. Twenty-eight patients undergoing AVR were randomly assigned to receive either stented or stentless. Echocardiograms, by means of M-mode and Doppler were performed early, 3-6 months and 1 year postoperatively. Results. The peak flow velocity was significantly lower in teh stentless group, especially 1 week and 6 months after surgery. Mean transvalvular gradient dropped significantly in stentless group and did not change in stented group. EOA did not change significantly in either of groups. AoV velocity time integral was increasing in stentless group. LV mass had fallen significantly in both groups but degree of mass reduction was comparable. Conclusions. There are marked improvements of stentless valves hemodynamics. However it is not necessary equal to higher degree of LV mass reduction during 1 year follow-up.


    203/2523

    Tytuł oryginału: Substance P content in the cerebrospinal fluid and fluid perfusing cerebral ventricles during elicitation and inhibition of trigemino-hypoglossal reflex in rats.
    Autorzy: Zubrzycka Maria, Janecka Anna
    Źródło: Brain Res. 2002: 941 (1/2) s.29-33, il., bibliogr. 47 poz.
    Sygnatura GBL: 312,085

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The aim of this study was to establish whether tooth pulp and periaqueductal central gray (PAG) stimulation affects the release of substance P (SP) into the fluid perfusing the cerebral ventricles in rats. The content of substance P in the cerebrospinal fluid and fluid perfusing cerebral ventricles was determined during incisor pulp stimulation with electrical impulses inducing nociceptive trigeminohypoglossal reflex and then during inhibition of the reflex by stimulation of PAG. Perfusion of the cerebral ventricles was carried out using artificial cerebrospinal fluid (aCSF). SP-like immunoreactivity (SP-LI) was determined in the samples by radioimmunoassay. Samples were collected in four groups: first group - cerebrospinal fluid (CSF); second group - aCSF perfusates without stimulation; third group-aCSF perfusates during incisor pulp stimulation; fourth group-aCSF perfusates during incisor pulp stimulation and simultaneous inhibition of trigemino-hpoglossal reflex by PAG stimulation. It was shown that incisor pulp stimulation led to the increased release of SP-LI into the fluid perfusing cerebral ventricles. Stimulation of PAG reduced the release of SP-LI into the cerebro-ventricular system to the values obtained before the tooth pulp stimulation. The results indicate that PAG significantly inhibits the release of SP-LI into the rat cerebral ventricular system and may be involved in the inhibition of trigemino-hypoglossal reflex.


    204/2523

    Tytuł oryginału: The beginnings of urology in Kraków: on the 70th anniversary of the founding of the Clinic of Urology.
    Autorzy: Dobrowolski Z. F., Swolkien J., Dobrowolska B., Lipczyński W., Jaszczyński J.
    Źródło: Br. J. Urol. 2002: 89 (6) s.596-598, bibliogr. 4 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca historyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • historia nowożytna
  • historia XIX wieku
  • historia XX wieku


    205/2523

    Tytuł oryginału: Survival in patients with rare subtypes of renal cell carcinoma.
    Autorzy: Grabowski M[arek], Huzarski T., Lubiński J., Sikorski A[ndrzej]
    Źródło: Br. J. Urol. 2002: 89 (6) s.599-600, tab., bibliogr. 14 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective. To evaluate the survival of patietns with rare malignant histological subtypes of renal cancer. Pateitns and methods. The Heidelberg classification of renal cell carcinoma (RCC) divides tumours into clear cell carcinoma (CCC), papillary cancer (PC), chromophobic cancer (ChC) and collecting duct carcinoma (CDC). Sarcomatoid tumours are in a different subgroup treated as a final stage of histological progression. Between 1990 and 1997, 319 nephrectomies were undertaken because of RCC in 317 patients. In 42 patietns (13 p.c.) the patholgoical findings showed other than CCC; in 13 PC was confirmed histolgoically, in nine ChC, in 11 a mixed type of CCC and sarcomatoid type, in seven a sarcomatoid tumour and in four, CDC. Results. One patietn of the 13 with PC and two of the nine with ChC died. The worst prognosis was in those with CDC, CCC-sarcomatoid and sarcomatoid tumours, as all these patietns died. Conclusion. The histopathological differentiation of RCC into subtypes gives additional useful prognostic information.


    206/2523

    Tytuł oryginału: Assessing the vascular-stromal coefficient in patients with benign prostatic hyperplasia or prostate cancer using transrectal ultrasonography and power Doppler analysis.
    Autorzy: Dobrowolski Z., Jaszczyński J., Drewniak T., Habrat W.
    Źródło: Br. J. Urol. 2002: 89 (6) s.601-603, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Objectives. To assess a coefficient of theprotatic blood supply in patietns with prostate cancer or benign prostatic hyperplasia (BPH), and thus improve the diagnostic and prognostic variables needed to evaluate patients with prostate cancer. Patietns and methods. The vascular-stromal coefficient was defined as the ratio of the blood vessel surface area and the surface area of the prostate, using power Doppler functions and transrectal ultrasonography. The index was calcualted for the plane of the prostatic surface from the apex to the widest points of the peripheral zone, and for the plane across the highest density of blood vessels in the transition zone. A micobubble contrast agent was used to intensify the acoustic signals from prostatic vessels. The images were reconstructed in three dimensions. In all, 61 patietns with BPH and 32 with confirmed prostate cancer were examined, and compared with a control group of young men. Results. In the horizontal plane crossing the apex of the prostate, the vascular-stromal coefficient was 0.0054 for the controls, 0.0072 for BPH and 0.0067 for cancer. At the level of the highest density of blood vessels the respective values were 0.0083, 0.038 and 0.029. The respective values for the first plane after using the contrast agent were 0.025, 0.092 and 0.0365, and in the second level 0.04, 0.15 and 0.14. Conclusion. The vascular-stromal coefficient measured at both levels was higher in patietns with BPH than in those with cancer or than in the controls. The prostatic vascular system can be computer-reconstructed in three dimensions, allowing an evaluation of asymmetry and other vascular abnormalities...


    207/2523

    Tytuł oryginału: Correlations among prostatic-specific antigen, Gleason score, staging and grading in patients after radical prostatectomy.
    Autorzy: Szymanowski J., Dudek P., Ratajski J., Wysocki M.
    Źródło: Br. J. Urol. 2002: 89 (6) s.612-613, tab., bibliogr. 6 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Objectives. To evaluate the correlation between Gleason grade, T stage, tumour grade and preoperative prostatespecific antigen (PSA) level ( or 20 ng/mL) in patietns after radical prostatectomy (RP). Patietns and methods. The serum total PSA level was measured 3 months before surgery in 87 patients who then undrewent RP between 1994 and 2000; the tumour specimens were staged and graded. Results. There were 57 (66 p.c.) patietns with a PSA level of 20 ng/mL; in this group only four (7 p.c.) patients had a Gleason grade of 7 and eight (14 p.c.) had G3 tumours. Thirty (34 p.c.) patients had a PSA level of 20 ng/mL; in this group only two (7 p.c.) patietns had a Gleason grade of 7 and 26 (87 p.c.) had G1 and G2 tumours. Conclusions. These results confirm our previous observations that the PSA level cannot be use as the only factor to indicate RP in patients with prostate cancer, but further evaluation on more patietns is needed.


    208/2523

    Tytuł oryginału: Vascular angiographic asymmetry on three-dimensional transrectal power Doppler ultrasonography in patients with organ-confined prostate cancer.
    Autorzy: Dobrowolski Z. F., Jaszczyński J., Drewniak T., Habrat W., Kusionowicz J.
    Źródło: Br. J. Urol. 2002: 89 (6) s.614-615, bibliogr. 7 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Objective. To assess whether organ-confined prostate cancer not detected on routine transrectal ultrasonography (TRUS) can be detected using threedimensional (3-D) power Doppler methods. Patients and methods. A preliminary trial of the use of TRUS with 3-D power Doppler image reconstruction was conducted in 116 patients being evaluated for lower urinary tract symptoms. Using a microbubble enhancing agent, a adequate horizontal plane allowed the simultaneous visualization and assessment of the symmetry of echogenicity and vascularization of the peripheral area of both prostate lobes, which is not possible in standard TRUS. The peripheral zone vascular asymmetry in the horizontal plane was also assessed retrospectively n those patients with pT2a,b prostate carcinoma. Results. Stage pT2a,b prostate carcinoma was confirmed in 26 patients; in this group, two independent investigators confirmed the vascular asymmetry between the left and right peripheral zone, in the horizontal plane, in 22 patients, giving a sensitivity of 85 p.c. Conclusions. Vascular asymmetry allows guided biopsy in lesions that are invisible using standard TRUS. Microbubble agents are an effective method of increasing the acoustic signals from small vessels of the prostate.


    209/2523

    Tytuł oryginału: Evaluation of the influence of systemic neoadjuvant chemotherapy on the survival of patietns treated for invasive bladder cancer.
    Autorzy: Kolaczyk W., Dembowski J[anusz], Lorenz J[erzy], Dudek K.
    Źródło: Br. J. Urol. 2002: 89 (6) s.616-619, il., bibliogr. 13 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Objective. To assess the influence of neoadjuvant systemic chemotherapy using a modified methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) scheme in patietns with invasive bladder cancer. Patients and methods. Two groups of patients were reviewed retrospectively: group 1 included 51 who received chemotherapy before cystectomy and group 2 included 62 who were treated only with surgery. The mean (range) duration of follow-up was 3.2 (0.25 - 10.25) years. The patients in group 1 were divided into two subgroups: those with tumour confined to the bladder (T1, T2 and T3a) and the remaining patients with tumour beyond the bladder (T3b, T4a,b). The chemotherapy was administered as routine MVAC, except vinblastine and methotrexate were given at 15 and 22 days during the cycle. A mean of three cycles were administered. Results. The 5-year survival rate in group 1 and 2 was 66 p.c. and 58 p.c., respectively (P 0.3); after 8 years of follow-up the survival rates were 58 p.c. and 33 p.c., respectively, and significantly different (P 0.01). Conclusion. Systemic chemotherapy using the modified MVAC scheme in patients subsequently undergoing radical cystectomy improved the survival rate after 8 years of follow-up.


    210/2523

    Tytuł oryginału: Treatment of high-risk superficial bladder cancer with maintenance bacille Calmette-Gu‚rin therapy: preliminary results.
    Autorzy: Kołodziej A., Dembowski J[anusz], Zdrojowy R[omuald], Woźniak P., Lorenz J[erzy]
    Źródło: Br. J. Urol. 2002: 89 (6) s.620-622, tab., bibliogr. 6 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia
  • toksykologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective. To evaluate, in a prospective study, the effects and results of maintenance therapy with bacille Calmette-Gu‚rin (BCG) in treating patietns with high-risk superficial bladder cancer. Patients and methods. In all, 155 patietns were enrolled in a randomized study of transurethral resection alone (53) or combined with intravesical BCG (102) as a treatmetn for superficial bladder cancer. BCG was administered for six consecutive weeks followed by three weekly instillations in months 3, 6, 12, 18, 24, 30 and 36 after resection. Recurrence, progression, prognostic factors and side-effects were assessed and analysed. Results. After a median (range) followup of 23 (6-42) months, 83 of the 102 patietns treated with BCG (81 p.c.) were disease-free, compared with 24 of the 53 treated with resection alone (45 p.c.). There was also a significant difference in tumour progression and time to progression between the trial arms. The disease progressed in eight patients (8 p.c.) treated with BCG and in 12 (23 p.c.) of those treated by resection alone. Independent risk factors for progression were DNA ploidy status and stage. Only the completion of treatment was predictive of outcome (risk of recurrence) for patietns treated with BCG. Conclusion. Maintenance BCG therapy was better than resection alone in reducing the incidence of recurrence and progression in patietns with high-risk superficial bladder cancer.


    211/2523

    Tytuł oryginału: Superficial bladder cancer T1G3: the choice of treatment.
    Autorzy: Borkowski A[ndrzej]
    Źródło: Br. J. Urol. 2002: 89 (6) s.623-627, tab., bibliogr. 41 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie


    212/2523

    Tytuł oryginału: Multivariate inference in clinical trials - tests with model choice, confidence regions.
    Autorzy: L„uter J., Kropf S.
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.5-16, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the paper, the formerly introduced spherical multivariate tests are coupled with procedures for selecting the relevant variables. These procedures work in such a way that a non-relevant set of variables is chosen with the probability of significance ŕ, at most. Furthermore, a new method of the calculation of linear principal-component scores is presented, which is based only on the within-sample covariances and yields, nevertheless, a level-ŕ test in each case. This method enables us to determine novel multivariate confidence regions of the unknown mean vector. The statistical procedures are demonstrated by a neurological example.


    213/2523

    Tytuł oryginału: Grade exploratory methods applied to some medical data sets.
    Autorzy: Pleszczyńska Elżbieta, Szczęsny Wiesław
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.17-30, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Two sets of medical categorical data are analysed by means of grade exploratory methods, based on one fundamental procedure called the grade correspondence analysis (GCA). A special attention is put on visualization. The paper is a contribution to discussion concerning visualization of categorical data, which is going on in contemporary statistical literature.


    214/2523

    Tytuł oryginału: On the generalised affinity coefficient for complex data.
    Autorzy: Bacelar-Nicolau Helena
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.31-42, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: This paper concerns the affinity coefficient and extensions for measuring the similarity between data units in classification, when we are dealing with large and complex databases. More precisely we refer to the extended weighted affinity coefficient and its role in hierarchical classification, when we are dealing with a generalised data table where the cells can contain a set of values, describing a probability distribution, a histogram (frequency distribution), or integer frequencies, for instance, instead one single value. Here we study the case of frequency distributions, since in our approach the other cases appear to be derived as a generalisation (integer frequencies, real data, for instance) or else as a particular case (binary data, ordinal data) of this one. Either the weighted affinity or the probablistic associated coefficients can be extended, in the clustering viewpoint, to hierarchical (and non-hierarchical) aggregation criteria and aggregation adaptive (parametric) families. An application to a real case is presented.


    215/2523

    Tytuł oryginału: Clinical databases orginating in electronic patients records.
    Autorzy: Zvarova Jana
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.43-60, il., bibliogr. 16 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: The paper is focusing on new technologies to standardize electronic documentation in Czech healthcare environment. Various approaches for collecting and stroing biomedical information using new information technologies are considered with respect to all legislative and standarization norms in the Czech Republic. Development of new approaches is based on experience gethered in the European 14C-TripleC project. New approaches for implementation of European ideas in the Czech healthcare environment are given. The focus on Czech healthcare, cultural and socio-economic factors in development of electronic healthcare record is presented. Special features of electronic healthcare record to serve in telematic applications for exploring electronic medical guidelines and medical decision support systems are discussed.


    216/2523

    Tytuł oryginału: Computer support of detecting risk of cardiovascular diseases.
    Autorzy: Franek Petr, Tomeckova Marie, Zvarova Jana
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.61-68, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The paper is focusing on analysis of data collected in twenty years lasting longitudinal study of 1417 middle-aged men living in the second district of Prague. Examination of methods that can support estimation of the risk of cardiovascular disease development in time is done. These methods examined were neural networks, discriminant analysis and logistic regression. The final comparison was done according to percentage of correct decicions and using ROC curves.


    217/2523

    Tytuł oryginału: Physical and mathematical model of human hip joint load.
    Autorzy: Włodarski Jerzy, Szmigiel Andrzej, Żołtyński Krystian, Kaczmarek Jan
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (1) s.95-102, il., bibliogr. 12 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Analysing human gait cyclogram and reactions of the foundation, kinematics and dynamics of loads realised on a test stand were tried to be brought closer to real object. To reconstruct hip joint load digram, basic loads resulting from physiology of movement were isolated. Physical model conditioned on gait cyclogram is designed to describe physical load of human hip joint and may be presented in the form of characteristic "double peak". Mathematical model of human hip joint load approximates with good accuracy time serious of five harmonics. This model has been adapted for the realisation of the design for a test stand - human hip joint simulator enabling to perform static and dynamic testing of an artificial hip joint.


    218/2523

    Tytuł oryginału: Vasopressinergic innervation of the pig pineal gland.
    Autorzy: Przybylska-Gornowicz Barbara, Lewczuk Bogdan, Moller Morten
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.3-8, il., bibliogr. 30 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie
  • płeć żeńska

    Streszczenie angielskie: An immunohistochemical study of the pineal gland of the domestic pig was carried out using the antisera raised against vasopressin (VP). The pineal glands were taken from the newborn, 21-day- and 7-month old female pigs. The pig pineal glands is moderately innervated by VP-immunoreactive nerve fibers. They run from the habenular commissure into the connective tissue septa and further into the pineal parenchyma. In the subependymal tissue as well as in the connective tissue septa, the fibres are smooth or with small varicosities and in the parenchyma with large ones. The obtained results point to extrapineal and extraepithalamic source of the fibres. The density of VP-immunoreactive fibers in the pineal gland of 7-month old pigs is higher than in the younger animals.


    219/2523

    Tytuł oryginału: Influence of 4-day long treatment with vasoactive intestinal peptide on ultrastructure and function of the rat pinealocytes in organ culture.
    Autorzy: Nowicki Marcin, Lewczuk Bogdan, Przybylska-Gornowicz Barbara
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.9-16, il., bibliogr. 35 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Vasoactive intestinal peptide (VIP) is one neuropeptides involved in the regulation of the pineal gland function. The acute treatment of rat pinealocytes with VIP caused in their biochemical parameters. The present study concerns the effects of the chronic treatment with VIP on ultrastructure and function of the rat pinealocytes in organ culture. The pineals of adult male rats were assigned to one of three groups and placed in organ culture for four consecutive days. The pineals of the first group were incubated in the control medium, the pineals of the second group - 12 hrs in control medium and 12 hrs in medium with 1 ćM VIP (between 20.00 and 8.00) during each day, the pineals of the third group - 24 hrs per day in medium with 1 ćM VIP. The melatonin concentration was measured using RIA and activity of enzymes using radiochemical methods. Point count method was used in quantitative ultrastructural analysis. Both modes of chronic treatment with VIP increased significantly the level of melatonin secretion during four days of the culture and the content of this hormone in the pineal explants at the end of the experiment. Treatment with the neuropeptide for 12 hrs and 24 hrs per day elevated also the activity of arylalkylamine N-acetyltransferase and hydroxyindole=O-methyltransferase. On the other hand. VIP had no effect on the activity of arylamine-N-acetyltransferase. VIP increased the relative volume of rough endoplasmic reticulum. Golgi apparatus and mitochondria and did not influence the relative volume of lysosomes and lipid droplets as well as the numerical...


    220/2523

    Tytuł oryginału: Noradrenergic and peptidergic innervation of the mammary gland in the immature pig.
    Autorzy: Franke-Radowiecka Amelia, Kaleczyc Jerzy, Klimczuk Magdalena, Łakomy Mirosław
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.17-25, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie
  • płeć żeńska

    Streszczenie angielskie: The presence and pattern of coexistence of some biologically active substances in nerve fibres supplying the mammary gland in the immature pig were studied using immunohistochemical methods. The substances studied included: protein gene product 9.5 (PGP), tyrosine hydroxylase (TH), somatostatin (SOM), neuropeptide Y (NPY), galanin (GAL), calcitonin gene-related peptide (CGRP) and substance P (SP). The mammary gland was found to be richly supplied by PGP-immunoreactive (PGP-IR) nerve fibres that surrounded blood vessels, bundles of smooth muscle cells and lactiferous ducts. The vast majority of these nerves also displayed immunoreactivity to TH. Immunoreactivity to SOM was observed in a moderate number of nerve fibres which were associated with smooth muscles of the nipple and blood vessels. Immunoreactivity to NPY occurred in many nerve fibres associated with blood vessela and in single nerves supplying smooth muscle cells. Solitary GAL-IR axons supplied mostly blood vessels. Many CGRP-IR nerve fibres were associated with both blood vessels and smooth muscles. SP-IR nerve fibres richly supplied blood vessels only. The colocalization study revealed that SOM, NPY and GAL partly colocalized with TH in nerve fibres supplying the porcine mammary gland.


    221/2523

    Tytuł oryginału: Immunohistochemical localization of the somatostatin receptor subtype 2A in the rat adrenal gland.
    Autorzy: Pisarek Hanna, Pawlikowski Marek
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.27-30, il., bibliogr. 15 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The immunohistochemical localization of the somatostatin receptor subtype sst2A was investigated in the rat adrenal gland using SS-800 polyclonal antibody. The ss2A immunopositivity was found in all adrenocortical zones and in adrenal medulla, the reaction being slightly more intense in zona glomerulosa and medulla. The administration of the potent agonist of sst2 receptors - octreotide - resulted in the enhancement of the immunopositivity in zone glomerulosa and medulla, whereas chronic exposure of the rats to diethylstilbestrol led to enhancement of the immunopositivity in zone glomerulosa and in the external part of zona fasciculata.


    222/2523

    Tytuł oryginału: The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells.
    Autorzy: Jakubowicz-Gil Joanna, Paduch Roman, Gawron Antoni, Kandefer-Szerszeń Martyna
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.31-35, il., bibliogr. 36 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Heat shock protein 27 (Hsp27) belongs to the group of proteins called molecular chaperones protecting normal and tumour cells against many stressors such as hyperthermia, several commonly used chemotherapeutics as well as other apoptotic stimuli. Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions. Our results indicate that Hsp27 expression is drug- and cell-type specific and depends on the culture model as well. HeLa, Hep-2 and HSF cell cultured in 3D model appeared to be more resistant to stimulatory or inhibitory effects of the applied drugs than cells cultured in 2D model. Only A549 cells cultured in 3D culture model appeared to be more susceptible and reacted to drugs and heat treatment with increased Hsp27 expression.


    223/2523

    Tytuł oryginału: Immunohistochemical assay of p53, cyclin D1, c-erbB2, EGFr and Ki-67 proteins in HPV-positive and HPV-negative cervical cancers.
    Autorzy: Kędzia Witold, Schmidt Marcin, Frankowski Andrzej, Spaczyński Marek
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (1) s.37-41, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: The purpose of the present study was to analyse clinical correlation between HPV type 16 and 18 infection, expression of p53, cyclin D1, Ki-67, c-erbB2 and EGFr gene products in cervical cancer cells as well as their nuclear ploidy. The morphological parameters evaluated, such as differentiation of carcinomas, vascular invasion, ploidy and expression of oncogenic proteins, indicate the increased biological malignancy of HPV 16/18-positive carcinomas. The majority of them were poorly differentiated revealed significantly higher frequence of vascular invasion (p 0.05), were more frequently aneuploid and showd overexpression of cyclin D1. The comparison of the data obtained with the mortality rate of the patients suggests that the overexpression of EGFr and moderate expression of Ki-67 seem to be unfavorable prognostic factors, regardless of the presence of HPV 16/18.


    224/2523

    Tytuł oryginału: Molecular basis of the pathogenicity of Proteus bacteria.
    Tytuł polski: Molekularne podstawy chorobotwórczości bakterii z rodzaju Proteus.
    Autorzy: Różalski Antoni
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.3-18, il., tab., bibliogr. 75 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie polskie: Bakterie Gram-ujemne z rodzaju Proteus, zaliczane do rodziny Enterobacteriaceae, są patogenami warunkowo-chorobotwórczymi, powodującymi m.in. zakażenia ran i układu moczowego (zakażenia dróg moczowych - urinary tract infections - UTI). Te ostatnie przebiegają z powikłaniami w postaci ostrego lub przewlekłego odmiedniczkowego zapalenia nerek i powstawania kamieni moczowych w pęcherzu i nerkach. Bakterie Proteus sp. są mikroorganizmami dimorficznymi, rosnąc na podłożu płynnym, stanowią krótkie pałeczki, tzw. komórki pływające, o długości 1 - 2 ćm, peritrychalnie urzęsione z 6 - 10 rzęskami na komórce. Po przeniesieniu na podłoże stałe komórki te różnicują się do długich form, wielkości 20 - 80 ćm, tzw. swarmer cells, z wieloma nukleoidami, nieprzedzielonymi przegrodami, ze zwiększoną nawet 500 razy liczbą rzęsek. Obie odmienne morfologicznie formy komórek Proteus, krótkie pałeczki i "swarmery" odgrywają rolę w chorobotwórczości, te ostatnie zwłaszcza w zakażeniach wstępujących, częściej powodowanych przez Proteus sp. Dotychczas zidentyfikowano następujące właściwości i czynniki chorobotwórczości tych bakterii: zjawisko rozpełzliwego wzrostu, fimbrie i glikokaliks odpowiedzialne za przyleganie, rzęski, właściwości inwazyjne, ureazę, deaminazy aminokwasów, proteazy, hemolizyny, polisacharyd powierzchniowy (CPS) i lipopolisacharyd (LPS, endotoksyna). Dyskutowane są ich genetyczna determinacja, podstawy molekularne i rola w chorobotwórczości Proteus sp.

    Streszczenie angielskie: Gram-negative bacteria of the genus Proteus from the family Enterobacteriaceae are opportunistic pathogens, which cause mainly wounds and urinary tract infections (UTI), the latter leading to severe complications, such as acute or chronic pyelonephrithis and formation of bladder and kidney stones. Proteus are dimorphic bacteria. When grown in a liquid medium, they are motile, peritrichously flagellated short rods, referred to as swimmer cells 1.0 to 2.0 ćm in length, with 6 - 10 flagella per cell. When transferred to a solid medium, Proteus short bacilli differentiate to swarmer cells, which are multinucleated, nonseptated cells 20 - 80 ćm in length containing even 500 fold more flagella. Both, short rods and long swarmer cells, are important in the pathogenesis of bacteria, the latter being particularly important in ascending UTI, which are more common for Proteus strains. Virulence factors and properties of Proteus sp. mediating infectious process are swarming phenomenon, adherence due to the fimbriae or glycocalyx, flagell, invasiveness, urease, amino acids deaminases, proteases, hemolysins, capsular polysaccharide (CPS), and lipopolysaccharide (LPS, endotoxin). The genetic determination, molecular basis, and the pathophysiological role of these factors in the infections caused by Proteus sp., are discussed.


    225/2523

    Tytuł oryginału: Late results of a phase-I trial for immunotherpay of pancreatic cancer.
    Tytuł polski: Późne wyniki pierwszej fazy badań nad immunoterapią raka trzustki.
    Autorzy: Waleczek Helfried, Lukenheimer Holger, Gerhards Roswitha, Werchau Hermann, Kozuschek Waldemar
    Opracowanie edytorskie: Knast Witold (koment.).
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.19-24, il., bibliogr. 25 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wprowadzenie. Na powierzchni komórek raka znajdują się antygeny swoiste dla rodzaju guza. W terapii nowotworu mogą więc znależć zastosowanie reakcje immunologiczne podobne do tych, jakie występują podczas procesu odrzucania przeszczepu. Wyniki leczenia raka trzustki są złe, nawet w przypadkach resekcji radykalnej. Terapia immunologiczna stanowi szansę na poprawę tych złych warunków. Cel pracy. Celem pracy była odpowiedź na pytanie, czy indywidualna odpowiedź immunologiczna może zostać pobudzona przez szczepionkę z zastosowaniem inaktywowancyh komórek raka zakażonych wirusem choroby Newcastle (NDV) pochodzących z autologicznych kultur komórek raka. Przedstawiono efekty kliniczne pierwszej fazy badań. Omówono również najnowsze piśmiennictwo poświecone badaniom z tej dziedziny (od 1995 r.). Materiał i metoda. Dziewięciu pacjentów zostało poddanych pełnej immunizacji po radykalnych operacjach z powodu raka trzustki wykonanych w latach 1992 - 1995. Hodowle komórkowe były prowadzone indywidualnie, jako kultury autologiczne, zostały zakażone NDV i inaktywowane odpowiednio do swej chemowrażliwości. Po zakończeniu pełnego szczepienia pacjentów miejsca odczynu skórnego na niezmodyfikowany materiał autologiczny guza wycinano i poddano badaniom immunohistochemicznym. Badania objęły okres do 2001 r. Wyniki. U wszystkich pacjentów stwierdzono indukcję lub wzmożenie nadwrażliwości typu późnego na autologiczny materiał guza. Reakcji tej nie odnotowano w stosunku do nieswoistych ...

    Streszczenie angielskie: Background. Carcinoma cells present tumorspecific antigens on their cell surfaces. Thus immunological reactions similar to transplant rejections may be induced and used in tumor therapy. Results of therapy for cancer of the pancreas are still very poor even after complete resection. Immunological approaches may improve patients outcome. Objectives. The aim of the study was to determine whether an individual immunological response could be induced by vaccination with Newcastle Disease Virus (NDV) infected inactivated cancer cells from autologous tumor cell cultures. Clinical effects of a phase I trial were recorded. New insights since 1995 are discussed. Material and methods. 9 patients could be immunized completely after curative resection fo adenocarcinomas of the pancreas between 1992 and 1995. Tumors were grown individually as autologous cell cultures, NDV infected and inactivated according to their chemosensitivity. After complete vaccination patients reaction sites to unmodified autologous tumor material were resected and tested by immunohistochemistry. Clinical outcome up to 2001 was recorded. Results. All patients showed induction or inhancement of delayed type hypersensitivity to autologous tumor amterial but not to unspecific markers. No patient showed vaccination site skin metastasis development. No hepatic metastasis occurred in the vaccination group. 7 of these patients died due to local (retroperitoneal) tumor growth. 2 patients have no recurrent tumor ...


    226/2523

    Tytuł oryginału: GSTT1 and GSTM1 polymorphism in patients with the carcinoma laryngis.
    Tytuł polski: Polimorfizm genów GSTT1 i GSTM1 u pacjentów chorych na raka krtani.
    Autorzy: Schlade-Bartusiak Kamilla, Zych Monika, Kręcicki Tomasz, Sąsiadek Maria
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.25-27, tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. W etiologii dużą rolę odgrywają czynniki środowiskowe (głównie palenie papierosów i spożywanie alkoholu), ale jedynie u około 10 - 15 proc. palaczy występuje ten typ nowotworu. Zdeterminowana genetycznie podatność na powstawanie HNSCC może zależeć od aktywności metabolicznej enzymów detoksyfikujących karcinogeny obecne w dymie tytoniowym. Jedną z grup takich enzymów jest wielogenowa rodzina transferaz S-glutation. Geny GSTT1 i GSTM1 charakteryzują się polimorfizmem, który można wykryć, jeśli delecji ulegają obie kopie genu. Cel pracy. Celem pracy było zbadanie częstości delecji genów GSTT1 i GSTM1 u pacjentów z HNSCC w porównaniu z populacją kontrolną. Materiał i metody. Polimorfizm genów GSTT1 i GSTM1 badano technika PCR u 40 pacjentów chorych na raka krtani i u 77 osób z grupy kontrolnej. Wyniki. Nie stwierdzono znaczącej statystycznie różnicy między częstością delecji badanych genów u pacjentów z HNSCC w porównaniu z grupą kontrolną. Wnioski. Otrzymane wyniki sugerują brak wpływu delecji badanych genów na częstość występowania HNSCC.

    Streszczenie angielskie: Background. Environmental factors (mainly cigarette smoking and alcohol consumption) play an important role in eatiology of head and neck squamous cell carcinoma (HNSCC), but only about 10 - 15 p.c. of heavy smokers develop this type of cancer. Genetically determined susceptibility to HNSCC may depend on the metabolic activity of enzymes that detoxify carcinogens present in tobacco smoke. One group of these enzymes is a multigene family of glutathione S-transferases. The GSTT1 and GSTM1 genes are known to be polymorphic. Polymorphic forms resulting from gene deletion are characterized by the lack of a detectable gene and are called null genotypes. Objectives. The aim of the present study was to investigate the frequency of GSTT1 and GSTM1 null genotypes in HNSCC patients in comparison to a control population. Material and methods. The PCR-based analysis of GSTT1 and GSTM1 polymorphism was done in the group of 40 cancer patients and 77 healthy controls. Results. Our results show no statistically significant difference in the distribution of GSTM1 and GSTT1 genotypes between the tested groups. Conclusions. The results are in agreement with the studies of other authors suggesting no involvement of the GSTM1 or GSTT1 null genotypes in the risk of HNSCC.


    227/2523

    Tytuł oryginału: Principal component analysis of patient variables as an objective method of treatment evaluation in adolescent idiopathic scoliosis.
    Tytuł polski: Analiza składników głównych jako obiektywny sposób oceny leczenia skoliozy idiopatycznej.
    Autorzy: Buciński Adam, Kowalski Ireneusz M., Zarzycki Daniel, Bączek Tomasz, Nasal Antoni, Kaliszan Roman
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (1) s.61-68, il., tab., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wprowadzenie. Analiza składników głównych (PCA - principal component analysis) została wykorzystana do oceny strategii terapeutycznej leczenia skoliozy idiopatycznej. Analiza PCA została przeprowadzona na dużym zbiorze wskaźników klinicznych. Metoda pozwoliła na ocenę złożonych zależności między zmiennymi charakteryzującymi pacjentów, chorobę i postępowanie terapeutyczne. Materiał i metody. Studia przeprowadzono na grupie 294 pacjentów, których charakteryzowały 137 zmienne. Wszystkich pacjentów poddano standardowej procedurze rehabilitacyjnej, przy czym 180 z nich było dodatkowo leczonych metodą elektrostymulacji LESS (lateral electrical surface stimulation). Macierz 137 zmiennych x 294 przypadki została poddana analizie składników głównych za pomocą programu Statistica (StatSoft Inc., Tulsa, OK, USA). Wyniki. Wyekstrahowane trzy składniki główne, PC1, PC2 i PC3 opisały 13 proc. całkowitej zmienności próby. Wyraźne zróżnicowanie położeń punktów w przestrzeni wyznaczonej przez trzy pierwsze składniki główne interpretowano w kategoriach podobieństw (różnic) między przypadkami. Wnioski. Wykazano, że postępowanie terapeutyczne włączające elektrostymulację LESS pozytywnie wpływa na leczenie skoliozy idiopatycznej.

    Streszczenie angielskie: Background. An advanced multivariate data processing method, principal component analysis (PCA), was demonstrated to provide an objective evaluation of treatmetn strategy by making use of large collections of routine clinical parameters of adolescent idiopathic scoliosis patients. The method allowed for detection of complex systematic relationships between diverse patient, disease and treatment variables. Material and methods. Two hundred ninety four patients with adolescent idiopathic scoliosis were the subject of the study for whose one hundred thirty seven disease and treatment variables were determined. It was revealed by PCA that a lateral electrical surface stimulation (LESS) treatment positively affected the outcome of adolescent idiopathic scoliosis. A matrix of 294 x 137 data points was analyzed by PCA employing a commercially available statistical softwar and a personal computer. All the 294 patients underwent standard rehabilitation procedure and 180 of them were subjected additionally to LESS treatment. Results. Three principal components, PC1, PC2 and PC3, were extracted which accounted cumulatively for 13 p.c. of the variance of the data analyzed. An apparent clustering of the variables and a clear cut clustering of the patients were observed, which have been interpreted in terms of similarity (dissimilarity) of the variables and of the patients. Principal component analysis has been recommended as a new promising altlernative to classical regression analysis of multivariable clinical data. By means of PCA practically useful systematic information may be extracted from large sets of data otherwise hardly interpretable in comphrehensive physical terms...


    228/2523

    Tytuł oryginału: Remnants of respiratory peaks in heart rate variability spectrum of an adult man with tachypnea and bradycardia.
    Tytuł polski: Pozostałości pików oddechowych w widmie zmienności rytmu serca dorosłego człowieka z szybkim rytmem oddechowym i wolnym rytmem serca.
    Autorzy: Sacha Jerzy, Grzeszczak Władysław
    Źródło: Folia Cardiol. 2002: 9 (1) s.67-74, il., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 313,196

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie polskie: Analiza zmienności rytmu serca (HRV) w dziedzinie częstotliwości jest użytecznym narzędziem do badania fluktuacji rytmu zatokowego powodowanych przez autonomiczny układ nerwowy. Jednakże, nie jest jasne, jaka jest górna granica częstotliwości, która może być analizowana w widmie HRV. Materiał i metody: Badamy widma HRV dorosłego ochotnika z szybkim rytmem oddechowym, gdy jego rytm jest zwalniany bądź przyspieszany. Stosując szybką tranformatę Fouriera (FFT), analizujemy serie odstępów między uderzeniami serca w dziedzinie częstotliwość. Przeprowadzamy również komputerowe symulacje mierzonych sygnałów i porównujemy otrzymane z widmiami ochotnika. Wyniki: Jeżeli częstość oddechów przekracza połowę średniej częstości uderzeń serca, w widmie HRV są obecne dwa piki reprezentujące ten sam sygnał oddechowy. Jeden z pików jest wynikiem zjawiska aliasingu, natomiast drugi jest pozostałością prawdziwego piku oddechowego, jako efekt właściwości symetrii FFT. Żaden z nich nie przynosi rzetelnej, ilościowej informacji o fali oddechowej w widmie HRV. Wnioski: Górna granica częstotliwości w widmie HRV jest zdeterminowana przez połowę średniej częstotliwości serca. Przed obliczaniem widma należy więc określic górny możliwy do analizy limit częstotliwości, by uniknąć sytuacji, w której analizowane zakresy lokalizują się poza tą granicą. Sytuacja jest taka wielce prawdopodobna w przypadku, gdy pacjent wykazuje wolną akcję serca.

    Streszczenie angielskie: Introduction: Heart rate variability (HRV) analysis in frequency domain is a useful tool to investigate fluctuations of the sinus rhythm caused by the nervous system. However, it is not clear what the upper limit of the frequency where the HRV spectrum is reliable is. Material and methods: We investigated HRV spectra of an adult man with high respiratory rate when his heartbeat rate was slowed down or accelerated. We applied Fast Fiurier Transform (FFT) to analyse the discrete event series in the frequency domain. We also performed numerical simulations of measured signals and compared the resulting spectra with those of the man. Results: It the respiration rate exceeds half of the average heartbeat rate, two peaks corresponding to the same respiratory signal can be found in the spectrum. One of them results from the aliasing phenomenon but the other is a remnant of the true respiratory peak whose origin lies in the symmetry properties of FFT. None of the peaks brings reliable, quantitative information about the respiration wave in the HRV spectrum. Conclusion: The upper frequency limit in a hRV spectrum is determined by half of the average heartbeat frequency. Consequently, one should check if any considered fluctuation lies within this frequency range, otherwise there is no reliable information about the fluctuation in the HRV spectrum. Such a situation is likely to occur when a patient exhibits slow heart rate.


    229/2523

    Tytuł oryginału: Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum.
    Autorzy: Błaszkowska Joanna
    Źródło: Wiad. Parazytol. 2002: 48 (1) s.55-64, il., tab., bibliogr. [33] poz.
    Sygnatura GBL: 303,658

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • zarodki
  • ptaki

    Streszczenie angielskie: It has been found that trypsin and ŕ-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn chicken embryos. Mortality rate for the chicken embryos on day 15 of incubation was 45.0 ń 3.5 p.c. after injection of trypsin inhibitor and 44.0 ń 3.5 p.c. after adminstration ŕ-chymotrypsin inhibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformationsd was foundf after administration of ŕ-chymotrypsin inhibitor. The most commonly occurring abnormality was schistocelia (21.4 ń 3.88 p.c.). Growth malformations were not found in the control groups. The trypsin and ŕ-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on ther development of the chicken embryo.


    230/2523

    Tytuł oryginału: Sprawozdanie z II Międzynarodowej Konferencji "A Sound fundation through early amplification", Chicago 6-10.XI.2001.
    Autorzy: Obrębowski Andrzej
    Źródło: Otolaryngol. Pol. 2002: 56 (2) s.275-276 - 2 Międzynarodowa Konferencja pt. Wczesna amplifikacja dżwięku Chicago 08-10.11. 2001
    Sygnatura GBL: 313,466

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • sprawozdanie
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    231/2523

    Tytuł oryginału: Hypoxic-ischemic encephalopathy: pathophysiology and implications for therapy.
    Tytuł polski: Encefalopatia niedotlenieniowo-niedokrwienna u noworodków.
    Autorzy: Sunshine Philip
    Źródło: Prz. Lek. 2002: 59 supl. 1: Międzynarodowa konferencja "Postępy w neonatologii" s.6-9, bibliogr. 37 poz., streszcz. - Międzynarodowa konferencja pt. Postępy w neonatologii Kraków 18-20.04. 2002
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie polskie: Encefalopatia niedotlenieniowo-niedokrwienna u noworodków wciąż jest ważnym problemem medycznym z uwagi na dużą śmiertelność, a także występujące u przeżywających niemowląt następstwa neurologiczne i upośledzenie intelektualne. Oprócz początkowej ostrej martwicy neuronów, wtórne ich uszkodzenie spowodowane reperfuzją dokonuje się przez 6 do 72 godzin od pierwotnego urazu. Wtórna niedomoga energetyczna komórek, rozpad błon komórkowych, dokomórkowy napływ jonów wapnia, produkcja cytokin oraz oksydacja przekaźnikowych aminokwasów - wszystko to przyczynia się do przyspieszonej i wzmożonej apoptozy neuronów. Nowe metody leczenia, takie jak stosowanie inhibitorów wolnych rodników tlenowych oraz utrzymywanie przez pierwsze 72 godziny życia łagodnej lub umiarkowanej hipotermii ogólnoustrojowej lub wybiórczej hipotermii głowy są obiecującymi środkami pomocniczymi w postępowaniu z noworodkami z encefalopatią niedotlenieniowo-niedokrwienną.

    Streszczenie angielskie: Hypoxic-ischemic encephalopathy continues to be a major problem in perinatal medicine because of the high mortality rate and neurological and intellectual imparment in the surviving infants. In addition to the acute necrotic damage that occurs in the neurons initially, reperfusion injury and secondary neuronal damage continue for 6 to 72 hours after the initial insult. Secondary cellular energy failure, membrane breakdown, cellular influx of calcium ions, elaboration of cytokines, and oxidation of excitory amino acids all contribute to enhanced apoptosis of the neurons. Newer forms of therapy including the use of oxygen-free radical inhibitors and mild to moderate cerebral or systemic hypothermia for 72 hours following the asphyxial period are promised adjuncts as follow-up approaches to the affected newborns.


    232/2523

    Tytuł oryginału: Status report: inhaled nitric oxide in persistent pulmonary hypertension/hypoxic respiratory failure of neonate.
    Tytuł polski: Zastosowanie tlenku azotu w leczeniu zespołu zaburzeń oddychania oraz przetrwałego nadciśnienia płucnego noworodków.
    Autorzy: Cook Larry N.
    Źródło: Prz. Lek. 2002: 59 supl. 1: Międzynarodowa konferencja "Postępy w neonatologii" s.10-13, bibliogr. 50 poz., streszcz. - Międzynarodowa konferencja pt. Postępy w neonatologii Kraków 18-20.04. 2002
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie polskie: Przetrwałe nadciśnienie płucne noworodków (PPHN) może być obserwowane w przebiegu różnych zaburzeń, w tym m. in. u dzieci z ciężką zamartwicą, zespołem aspiracji smółki, posocznicą wywołaną przez paciorkowce grupy B lub też u chorych z wadami wrodzonymi jak np. wrodzoną przepukliną przeponową. W pierwszej części omówiono stosowanie standardowych metod leczenia jak również użyteczność podawania surfaktantu i wentylacji wysokimi częstotliwościami u noworodków z PPHN. Następnie przedstawiono zasadę działania wziewnego tlenku azotu (iNO) oraz oceniono wyniki badń klinicznych na temat skuteczności tlenku azotu u noworodków z PPHN. Omówiono nowe kierunki badawcze, w tym stosowanie iNO u wcześniaków z zespołem zaburzeń oddychania oraz możliwości wykorzystanmia iNO w profilaktyce przewlekłej choroby płuc u wcześniaków. Przedstawiono aktualne zalecenia na temat dawkowania iNO u noworodków oraz aktualnie opublikowane wytyczne Amerykańskiej Adakemii Pediatrii na temat stosowania iNO u noworodków. W ostatniej części dokonano przeglądu dostępnych badań klinicznych oceniających odległe wuniki leczenia iNO u noworodków.

    Streszczenie angielskie: Presistent pulmonary hypertension is seen in association with a number of diseases and conditions in the newborn including perinatal asphyxia, meconium aspiration syndrome, Group B strep sepsis, and certain surgical conditions such as congenital diaphragmatic hernia. The conventional therapy of persistent pulmonary hypertension is discussed as well as the adjunctive role of surfactant replacement therapy and high frequency ventilation. The mechanisms of action of inhaled nitric oxides as a selective pulmonary vasodolator is explained. Human neonatal clinical experience is chronicled from the original studies of Roberts in 1992 and Kinsella in 1993. A review of three large prospective randomized trials of nitric oxides is presented as well as a summary of new areas of investigation including the use of nitric oxide in pre-term infants and the use of nitric oxide in the prevention of chronic disease. Current dosing recomendations are presented as well as guidelines recently published from the American Academy of Pediatrics. A review of follow up literature in relationship to patients receiving inhaled nitric oxides is also summarized.


    233/2523

    Tytuł oryginału: T type 1/type 2 subsets balance in B-cell chronic lymphocytic leukemia - the three-color flow cytometry analysis.
    Autorzy: Podhorecka Monika, Dmoszyńska Anna, Roliński Jacek, Wąsik Ewa
    Źródło: Leuk. Res. 2002: 26 (7) s.657-660, il., bibliogr. 8 poz.
    Sygnatura GBL: 306,151

    Hasła klasyfikacyjne GBL:
  • immunologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The impairments in immune cell functions as well as changes in cytokine network are the cause of malignant cell accumulation and secondary immune deficiencies in B-cell chronic limphocytic leukemia (B-CLL). To broaden the knowledge of immune system in B-CLL we tried to evaluate the Th1/Th2 and Tc2 balance in B-CLL patients in comparison with healthy individuals and changes of this pattern during disease progression. The three-color flow cytometry technique was used to analyze IL-4 and IFNç expression in peripheral blood CD3+CD4+ and CD3+CD8+ cells. The results indicate the dominance of T type 1 cells and T-cell-mediated immunity in B-CLL patients that is however shifted towards T type 2 during disease progression.


    234/2523

    Tytuł oryginału: Morphine attenuates pain and prevents inflammation in experimental peritonitis.
    Autorzy: Płytycz Barbara, Natorska Joanna
    Źródło: Trends Immunol. 2002: 23 (7) s.345-346, il., bibliogr. 13 poz.
    Sygnatura GBL: 312,774

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy


    235/2523

    Tytuł oryginału: Primenenie mediastinoskopii w diagnostike khirurgicheskikh zabolevanij organov grudnoj polosti.
    Tytuł angielski: Application of mediastinoscopy in diagnosis of surgical diseases of the thoracic cavity organs.
    Autorzy: Pieluchowski S. W.
    Źródło: Klin. Khir. 2002 (1) s.58-59, bibliogr. 5 poz.
    Sygnatura GBL: 303,753

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • komunikat
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    236/2523

    Tytuł oryginału: Oslozhnenija posle operacij s primeneniem videotorakoskopii i ikh lechenie.
    Tytuł angielski: Complications after operation with videothoracoscopy application and their treatment.
    Autorzy: Pieluchowski S. W., Piwkowskij C., Kasprzak P.
    Źródło: Klin. Khir. 2002 (2) s.30-31, bibliogr. 6 poz., sum.
    Sygnatura GBL: 303,753

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Of 4715 patient, who were present in 1995-2000 yrs in the clinic, in 708 (15 p.c.) operation, using videothoracoscopy method, was performed. In 539 (76.1 p.c.) of patietns the method was applied for diagnosis and in 169 (23.9 p.c.) - for treatment. After the operation 365 patients were observed, complications have occurred in 14, including the early - in 10 (2.7 p.c.) and the late - in 4 (1.1 p.c.). All the patients have survived.


    237/2523

    Tytuł oryginału: Analysis of Ixodes ricinus (L.) tick burdens in a resident passerine bird community in the Mazurian Lake region (Northeastern Poland).
    Autorzy: Gryczyńska Alicja, Barkowska Miłosława, Siemiątkowski Marek
    Źródło: Acta Parasitol. 2002: 47 (1) s.51-57, il., tab., bibliogr. [32] poz.
    Sygnatura GBL: 303,018

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The abundance of birds and their tick parasites were estimated in a residential avian community located in the Mazurian Lake region (NE Poland). A total of 1624 passerine birds (representing 45 species) were captured, of which 25 p.c. were infested with at least one tick. All the ticks belonged to the species Ixodes ricinus. The highest tick infestation prevalence ( 50 p.c.) were recorded for dunnock (Prunella modularis), tree pipit (Anthus trivialis), hawfinch (Coccothraustes coccothraustes) and blackbird (Turdus merula). Changes in tick infestation prevalence of passerine birds are seasonal. June and September were the two months in which tick infestation rates were the highest. The percentage of birds that were tick carriers was significantly greater in mixed coniferous forest than in alder swamp forest (respectively 32 p.c and 20 p.c. of birds were infested with ticks).


    238/2523

    Tytuł oryginału: Experimental Chagas'disease: the protection induced by immunization with Trypanosoma rangeli is associated with down-regulation of IL-6, TNF-ŕ and IL-10 synthesis.
    Autorzy: Cervetta Liliana, Moretti Edgardo, Basso Beatriz
    Źródło: Acta Parasitol. 2002: 47 (1) s.73-78, il., bibliogr. [36] poz.
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In an experimental model developed in our laboratory, BALB/c mice were protected against Trypanosoma cruzi infection by immunization with T. rangeli, a parasite closely related to T. cruzi but not pathogenic for man. Immunized mice developed low parasitemia and high survival rates when challenged with T. cruzi. In the present work, we study the patterns of systemic production of interleukin (IL-6), tumor necrosis factor alfa (TNF-ŕ), interferon gamma (IFN-ç), IL-2, IL-4 and IL-10 during the acute phase of T. cruzi infection in mice previously immunized with T. rangeli with respect with respect to only infected mice. The results showed a concentration of IL-6, TNF-ŕ and il-10 significantly lower in immunized mice than in only infected ones. The production of IFN-ç, a cytokine involved in resistance, was preserved in vaccinated mice. Finally, both groups of animals showed IL-2 and IL-4 serum levels similar to those observed in uninfected mice. As in other experimental or human infections, in this model, the pattern of systemic production of cytokines can be associated with the outcome of infection.


    239/2523

    Tytuł oryginału: A new automatized fluorometric assay for anti-Leishmania drug screening.
    Autorzy: Le Pape Patrice, Pagniez Fabrice, Abdala Hiam
    Źródło: Acta Parasitol. 2002: 47 (1) s.79-81, il., tab., bibliogr. [11] poz.
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: The therapeutic armentarium against leishmaniasis is very restricted, using mainly up to now drugs showing several side effects and resistance. Consequently, there is a real need to find new compounds as alternatives for the treatment of leishmaniasis. However, most of the classic antileishmanial primary screening assays are not suitable for measuring the cytotoxicity of large number of drug candidates because of the manipulation required. we have established a new assay that incorporate a fluorometric growth indicator based on the detection of a metabolic activity in culture medium after the chemical reduction of alamar Blue by cells. This antileishmanial test was evaluated on amphotericin B. meglumine antimoniate, allopurinol, ketoconazole and edelfosine. The results reported show the advantages of this fluorochrome on the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) for Leishmania cytotoxicity measurement. Moreover, this study is the first report of the use of alamar Blue flurogenic assay for activity assessment of potential antileishmanial drugs against promastigotes.


    240/2523

    Tytuł oryginału: Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock.
    Autorzy: Luchowska Elżbieta, Luchowski Piotr, Wielosz Marian, Kleinrok Zdzisław, Czuczwar Stanisław J., Urbańska Ewa M.
    Źródło: Pharmacol. Biochem. Behav. 2002: 71 (1/2) s.223-231, il., tab., bibliogr. [40] poz.
    Sygnatura GBL: 312,498

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The anticoconvulsive potential of classical antiepileptics co-administered with á-adrenergic receptor antagonists against generalized tonic-clonic seizures was evaluated in the model of maximal electroshock (MES)-induced convulsions. Propranolol, acebutolol, metoprolol and atenolol were tested in the doses not affecting the electroconvulsive threshold. Propranolol and metoprolol lowered the ED50 of valproate and diazepam. Acebutolol reduced valproate's but not diazepam's ED50 value. In contrast, hydrophilic atenolol, not penetrating via blood-brain barrier, affected neither the action of valproate nor diazepam. None of the studied drugs changed the protective activity of carbamazepine and phenytoin against MES. á-blokers per se did not alter the motor performance of mice. Moreover, propranolol and metoprolol did not influence diazepam-evoked impairment of locomotor activity. The free plasma and brain levels of antiepileptic drugs were not affected by á-blokers. In conclusion, the use of certain á-adrenoceptor antagonists, such as propranolol and metroprolol, might improve the antiepileptic potential of valproate and diazepam.


    241/2523

    Tytuł oryginału: Sarcal nerve modulation for fecal incontinence. Functional results and assessment of the quality of life.
    Tytuł polski: Pobudzenie nerwów krzyżowych w leczeniu nietrzymania stolca. Ocena wyników czynnościowych i jakości życia.
    Autorzy: Ganio E[nzo], Luc Realis A., Ratto C., Doglietto G. B., Masin A., Dodi G., Altomare D. F., Memeo V., Rippeti V., Arullani A., Falletto E., Gaetini , Scarpino O., Saba V., Infantino A., La Manna S., Ferulano , Villani R.
    Źródło: Proktologia 2002: 3 (2) s.121-126, il., bibliogr. 13 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Bezpośrednia stymulacja nerwu sromowego w sytuacji morfologicznie nieuszkodzonych zwieraczy odbytu stanowi atrakcyjną możliwość leczenia nietrzymania stolca, pozwalającą wykorzystać istniejący aparat zwieraczowy. Oceniano metodę bezpośredniej stymulacji korzeni krzyżowych pod kątem wykonalności, bezpieczeństwa, skuteczności i jej wpływu na jakość życia pacjentów. Badaniem objęto 116 pacjentów z nietrzymaniem stolca stałego i płynnego przynajmniej raz w tygodniu przez co najmniej 2 tygodnie, nie reagujących na leczenie konwencjonalne. W znieczuleniu miejscowym wprowadzono igłę do nakłucia lędźwiowego, którą następnie zastępowano czasowym przewodem stymulatora. Stymulacja nerwów powodowała ściśle określoną reakcję ruchową w zakresie krocza, zwieraczy, a także ruch nogi. U pacjentów poddanych stymulacji zaobserwowano poprawę funkcji zwieraczy, ze zmniejszeniem się liczby epizodów nietrzymania średnio z 11 do 3. Wśród 36 osób zakwalifikowanych do implantacji stymulatora na stałe liczba epizodów nietrzymania zmniejszyła się średnio z 15 do 3,3 w okresie 14 dni. Manometria anorektalna nie wykazała statystycznie znamiennych różnic. Uzyskano także poprawę w zakresie drobnych epizodów nietrzymania (popuszczanie gazu albo brudzenie bielizny), ze zmniejszeniem się ich liczby z 41,6 do 4,2. Wyniki tego badania dowodzą, że w wybranych przypadkach neuromodulacja krzyżowa stanowi nową i skuteczną metodę leczenia nietrzymania stolca. Po zastosowaniu symulatora stwierdzono również statystycznie znamienną korelację między poprawą wskaźników zdrowia psychicznego i somatycznego oraz poprawę stanu czynnościowego zwieraczy.

    Streszczenie angielskie: Direct stimulation of the pudendal nerve in a morphologically intact anal sphincter is an attractive treatment option as it allows use of the anatomical existing sphincters. Method of direct stimulation of the sacral roots was evaluated according to feasibility, safety, effectiveness and its impact on the patient's quality of life. The study included 116 patients with incontinence to solid and liquid stool once a week for at least 2 preceding weeks, which did not respond to conventional treatments. A spinal needle was inserted under the local anesthesia or temporary stimulator lead was used to replace it. Stimulation of nerves resulted in specific motor responses of the perineum and sphincters along with movement of the leg. Among the patients who underwent perineal nerve evaluation, an improvement was observed in continence, with a decrease in the number of incontinent episodes from mean of 11 to 3 episodes. Of 36 who were selected for definitive implant incontinence episodes decreased from 15 to 3.3 per 14 days. Anorectal manometry did not show any statistical difference. Improvement in the episodes of minor incontinence (to gas and soliting) was also seen with reduction from 41.6 episodes to 4.2. The study demonstrates that sacral neuromodulation in selected patients represents a new and effective tool in treatment. There was also a significant correlation between the mental and physical health indices and continence status after the implant.


    242/2523

    Tytuł oryginału: Combined parasacral and perineal approach in the surgical treatment of the anal incontinence.
    Tytuł polski: Skojarzone dojście kroczowe i okołokrzyżowe w leczeniu chirurgicznym nietrzymania stolca.
    Autorzy: Korcek J., Bakos E., Klobusicky P.
    Źródło: Proktologia 2002: 3 (2) s.127-132, il., tab., bibliogr. 14 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • chirurgia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Na podstawie własnych doświadczeń anatomicznych i klinicznych, a także doświadczeń związanych z leczeniem chirurgicznym nietrzymania stolca o różnej etiologii autorzy wykazali skuteczność i praktyczną przydatność skojarzonego dojścia przykrzyżowo-kroczowego (CPAPP) w chirurgicznym leczeniu nietrzymania stolca. Autorzy przeprowadzili powtarzane pomiary końcowej latencji ruchowej nerwu sromowego (PN TML) u 23 pacjentów z wydłużeniem latencji przed zabiegiem. Po operacji u 82,6 proc. pacjentów uzyskano prawidłowe wyniki PN TML, co korelowało z pełną sprawnością zwieracza.

    Streszczenie angielskie: In accordance with their own anatomic and clinical experiences as well as the experiences from the surgical therapy of various kinds of anal incontinence, the authors prove the expedience and effectiveness of the combined parasacral and perineal approach (CPAPP) in the surgical therapy of the anal incontinence. Authors performed a repetitive measuring the pudendal nerve terminal motor latency (PN TML) in the group of 23 patients with the pre-operative prolonged PN TML. 82.6 p.c. of the patients had postoperatively the normal values PN TML and this was in the correlation with the full continence.


    243/2523

    Tytuł oryginału: Pilonidal diseases: a review.
    Tytuł polski: Torbiel włosowata kości ogonowej. Przegląd.
    Autorzy: Casula G., Zorcolo L., Capra F., Scintu F.
    Źródło: Proktologia 2002: 3 (2) s.133-139, tab., bibliogr. 80 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Zatoka włosowata jest to ślepo zakończony przewód, o ścianach zbudowanych z ziarniny, zakończony jamą zawierającą włosy i złuszczony nabłonek. Może ona powodować znaczne kłopoty głównie u osób młodych, zarówno w skutek dyskomfortu, jak i straconego czasu pracy. Proponowano wiele różnych sposobów leczenia zatoki włosowatej, jednak większość z nich obarczona jest znacznym odsetkiem nawrotów. Są to różne metody - od prostego przyżegania, przez wstrzyknięcie fenolu, do złożonych zabiegów plastycznych. Największe prawdopodobieństwo powodzenia mają zabiegi chirurgiczne omijające linię środkową. Metoda Bascoma jest najprostszym sposobem uzyskania rany głównej poza linią środkową. Technika ta jest prosta i nadaje się do stosowania w warunkach "chirurgii jednego dnia" w znieczuleniu miejscowym. Daje też korzystne wyniki pod względem szybkiego powrotu do pracy i niewielkiego odsetka nawrotów. Autorzy uważają metodę Bascoma za metodę z wyboru w początkowym leczeniu objawowej zatoki włosowej. Asymetryczne wycięcie z pierwotnym zamknięciem skóry (zabieg Karidakiego) również stanowi korzystną alternatywę. Może być przeprowadzony w znieczuleniu miejscowym, jednak wiąże się z nieco większym odsetkiem powikłań i jest technicznie trudniejszy, ale ryzyko nawrotu jest tu mniejsze. Bardziej definitywna metoda, np. plastyka Z, jest zalecana u pacjentów z nawracającą i nie gojącą się raną w linii środkowej lub z nawracającą zatoką włosowatą.

    Streszczenie angielskie: Pilonidal sinus is blind-end track lined with granulation tissue, which leads to a cavity containing hairs and skin debris. It is a considerable source of problems in young patients both in terms of discomfort and time of work. Many procedures have been proposed for its management but most of them carry substantial persistence/recurrence rates. Treatments vary from simple cauterization with fenol injection to complex plastic procedures. Surgical procedures avoiding a wound in the midline are most likely to succeed. Bascom's technique is the simplest method to keep the main wound away from the midline. The technique is simple and suitable for one-day surgery in local anasthesia. It also gives favorable results in terms of return to work and rate of recurrence. Authors consider Bacom's technique the procedure of choice in the initial treatment of symptomatic pilonidal disease. Asymmetric excision with primary closure (Karidaki's procedure) is also an attractive option. It can performed under local anasthesia, has a little higher complication rate and is more complex, however is characterized by a lower risk of reccurence. More definitive treatments such as Z-plasty is probably the best choice in patients with persistently unhealed midline wound or recurrent pilonidal sinus.


    244/2523

    Tytuł oryginału: Local excision of rectal cancer.
    Tytuł polski: Miejscowe wycięcie raka odbytnicy.
    Autorzy: Rosa G., Lolli P., Piccinelli D., Bonomo S., Brugnettini F.
    Źródło: Proktologia 2002: 3 (2) s.140-142, bibliogr. 9 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Miejscowa resekcja jest możliwa jedynie u ok. 5 proc. pacjentów z rakiem odbytnicy, mimo widocznego ostatnio wzrostu zaintresowania tą metodą związanego z rozwojem nowych technik operacyjnych (m.in. TEM), rozszerzających możliwości działania chirurga i umożliwiających operowanie guzów zlokalizowanych nawet ponad 10 cm od brzegu odbytu. Kluczową sprawą pozostaje właściwe określenie wskazań, co z kolei determinuje wybór rodzaju operacji. Wskazania do miejscowej resekcji guza to: średnica guza nie przekraczająca 3 cm, guz egzofityczny (wyrasta do światła kanału odbytu), brak owrzodzeń, guz nie jest nieruchomy względem otoczenia, o niskiej złośliwości, zlokalizowany do 8 cm od brzegu odbytu (przy zastosowaniu metody tradycyjnej) albo do 12 cm na ścianie tylnej i do 15 cm na ścianie bocznej (przy zastosowaniu techniki TEM). Autorzy przeprowadzili 60 zabiegów miejscowej resekcji, z których 41 było zabiegiem definitywnym i dającym pełne wyleczenie. Pacjentów poddano ścisłej obserwacji przez 18 miesięcy, wykonując badania proktologiczne, proktoskopię, ultrasonografię transonalną oraz, w razie potrzeby, badania CT i MRI, a także rutynowe badania hematologiczne stosowane w onkologii. Dobre wyniki leczenia zależą od prawidłowego wyboru pacjentów z nowotworem w stadium T1, należących do grupy niskiego ryzyka.

    Streszczenie angielskie: Local excision remains a limited practice concerning only 5 p.c. of rectal cancers despite the fact that it has been given a new attention with new instruments (TEM) to extended the range of action allowing to reach neoplasms located over 10 cm from anus. The main issue remains correct indications, which determines the operation. Elective indications for local excision include: diameter of the tumor less than 3 cm, tumor has to be exofitic, non-ulcerated, non-fixed, low malignancy, located up to 8 cm from anus in case of traditional and up to 12 cm on the posterior, 15 on the lateral by TEM techniques. Authors performed 60 local excisions. 41 of them were considered definitive and curative. Close follow up for 18 months include proctologic examination, proctoscopy, transanal ultrasound, CT, MRI if necessary, hematological oncological routine. Good results depend on rigorous selection of patients with T1 at lower risk.


    245/2523

    Tytuł oryginału: Ambulatory surgery - what we can be done on a one day surgery basis in proctology?
    Tytuł polski: Chirurgia jednego dnia - jakie zabiegi mogą być wykonywane z zakresu proktologii?
    Autorzy: Kosorok Pavle, Pokrajac Tatjana
    Źródło: Proktologia 2002: 3 (2) s.143-147, il., bibliogr. 16 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wstęp: W naszej instytucji nabyliśmy wiele doświadczeń w dziedzinie proktologii. Siedem lat temu wprowadziliśmy do naszej praktyki "chirurgię jednego dnia" i uzyskaliśmy bardzo dobre wyniki leczenia praktycznie u wszystkich pacjentów wymagających chirurgicznego leczenia chorób proktologicznych. Materiał, metoda i wyniki: W tym okresie do leczenia chirurgicznego zakwalifikowano 6126 spośród 41913 pacjentów leczonych ambulatoryjnie . W grupie tej było 23,1 proc. pacjentów operowanych z powodu krwiaka okołoodbytowego. Uzyskaliśmy też pewne doświadczenia w zakresie drobnych zabiegów w okolicy odbytu (usunięcie wyrośli skórnych u 17,0 proc. pacjentów, wycięcie brodawek u 5,3 proc. pacjentów); pacjenci z chorobą hemoroidalną, operowani klasyczną metodą Milligana-Morgana (10,46 proc.) albo nową metodą PPH wg Longo (1,9 proc.). Leczono też 11,7 proc. pacjentów z przetoką okołoodbytniczą, stosując fistulotomię lub wycięcie przetoki, oraz 10,9 proc. pacjentów z drobnymi problemami chirurgicznymi (operacje włókniaków, torbieli naskórzastych, brodawek, ganglionów, tłuszczaków itp.). Usunęliśmy polipy odbytu i odbytnicy u 7,6 proc. pacjentów, torbiele przywłośne u 6,1 proc., leczyliśmy także 1,3 proc. pacjentów z ropniem odbytu. Wykonaliśmy beznapięciową plastykę przepukliny pachwinowej u 4,5 proc. pacjentów., a także korekcji stomii u 0,14 proc. pacjentów. Wnioski: W naszym doświadczeniu operacje w warunkach "chirurgii jednego dnia" stanowią właściwy sposób leczenia wielu ...

    Streszczenie angielskie: Introduction: In our institution we've had a lot of experience in proctology. Seven years ago we introduced one day surgery in our practice and had really good results in treating practically all patients who needed proctologic surgery. Material, methods and results: During this period of time 6,126 out of 41,913 outpatient cases were chosen for surgery. Among them, 23.1 p.c. were patients with operations of perinal haematomas. We had some experiences with minor anal surgery (excisions of skin tags in 17.0 p.c. patients, excisions of papillas in 5.3 p.c. patients); patients with haemorrhoids, operated classically on Milligan-Morgan procedure (10.46 p.c.) or by the new PPH - Longo procedure (1.9 p.c.). We also treated 11.7 p.c. patients with fistulas - either with fistulotomy or excision of fistulae - and 10.9 p.c. patients with minor surgery (operations of fibromas, verrucas, ganglions, lipomas, etc.). We made excisions of anorectal polyps in 7.6 p.c. patients, excisions of pilonidal cysts in 6.1 p.c. patients and treated 1.3 p.c. patients with anal abscesses. We made tension free operations of groin hernias in 4.5 p.c. patients and corrections of stomas in 0.14 p.c. patients. Conclusions: We have experienced ambulatory surgery (i.e. day surgery hospital) as an appropriate choice for treating the patients with proctologic pathology. However, it used to be the practice to treat all these patients in hospitals, where they occupied occupied bed facilities that could be ...


    246/2523

    Tytuł oryginału: New modalities in the treatment of haemorrhoids.
    Tytuł polski: Nowe metody leczenia choroby hemoroidalnej.
    Autorzy: Bielecki Krzysztof
    Źródło: Proktologia 2002: 3 (2) s.149-151, 153-154, tab., bibliogr. 15 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy omówiono leczenie choroby hemoroidalnej ze szczególnym uwzględnieniem nowych metod. Przedstawiono technikę i wyniki leczenia. Dokładnie omówiono wskazania i wyniki po stosowaniu staplerowej hemoroidektomii w odmianach Longo i Stram. Najbardziej rekomendowaną przez autora jest Doppler-duided haemorrhoidal artery ligation, która wydaje się być najmniej bolesną techniką leczenia.

    Streszczenie angielskie: In this paper various treatment options of haemorrhoidal disease are discussed, with special emphasis on new methods. Particular techniques and treatment results are presented. Indications and results of stapled haemorrhoidectomy by the Longo and the STRAM methods are discussed in detail. The author recomends the Doppler-guided haemorrhoidal artery ligation, which appears as the least traumatic and painful treatment technique.


    247/2523

    Tytuł oryginału: Indications and possibilities of semi-invasive treatment of hemorrhoids.
    Tytuł polski: Wskazania i możliwości półinwazyjnego leczenia choroby hemoroidalnej.
    Autorzy: Skricka Tomas, Vedra Pavel
    Źródło: Proktologia 2002: 3 (2) s.155, 157-161, il., bibliogr. 17 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Prawie 70 proc. osób dorosłych po 30. roku życia cierpi z powodu hemoroidów, mając objawy takie, jak krwawienie, ból i miejscowy odczyn zapalny. W tradycyjnym ujęciu nasilenie choroby określa się wg 4-stopniowej skali, zależnie od zakresu wypadania żylaków odbytu. W pierwszym etapie stosuje się leczenie farmakologiczne, ukierunkowane na zwalczanie krwawienia, bólu i podrażnienia, a także likwidację stanu zapalnego. Zaleca się miejscowe stosowanie środków antyseptycznych i antybiotyków, aby uniknąć miejscowego zakażenia. Metody półinwazyjne obejmują skleroterapię, krioterapię, fotokoagulację i podwiązanie gumowymi taśmami. W przypadku niewielkich hemoroidów, powodujących głównie krwawienie bez wypadania śluzówki, leczeniem z wyboru jest skleroterapia. Obecnie praktycznie zaprzestano wykonywania zabiegów krioterapii z uwagi na dużą bolesność i krwawienie. W przypadku hemoroidów pierwszego stopnia godną polecenia metodą jest fotokoagulacja. Zakładanie podwiązek gumowych pozwala uzyskać wyniki równie dobre jak przy zastosowaniu metod tradycyjnych, jednak zaletą podwiązek jest możliwość stosowania ich w warunkach ambulatoryjnych bez znieczulenia miejscowego. Metoda uważana jest za najlepszy i najbezpieczniejszy półinwazyjny sposób leczenia hemoroidów, nie tylko w przypadku choroby w drugim stopniu zaawansowania. Kombinacja diety, dbałości o prawidłowe wypróżnienia, farmakoterapię i leczeniapółinwazyjnego pozwala uzyskać dobre wyniki u ponad 90 proc. pacjentów.

    Streszczenie angielskie: Almost 70 p.c. of adult population over 30 suffer from haemorrhoids with symptoms of bledding, pain and inflammation. Traditional grading divides into four degrees depending on the extent of prolaps. First choice of treatment is drug therapy, which has to include therapy of bleeding, pain and irritation as well as anti-inflammatory. The use of antiseptics and antibiotics should be used by preference to guard against local infection. Semi-invasive therapy includes sclerotherapy, cryotherapy, fotocoagulation and rubber-band ligation. The sclerotherapy is the first line of treatment in minor degree heamorrhoids particularly those causing bleeding without mucosal prolapse. Cryotherapy is practically abandoned on the ground of pain and profuse discharge. Photocoagulation is good and sufficient method of treatment in the first-degree haemorrhoids. Rubberband ligation enables to achieve results as valid as those of traditional methods in the treatment of haemorrhoids with the advantage of employing it in out-patient development with no need for local anasthesia. It is considered to be the best and most safe semi-invasive method of treatment not only of the second-degree haemorrhoids. Combination of diet, improvement of emptying, pharmacotherapy and semi-invasive treatment can treat more that 90 p.c. patients successfully.


    248/2523

    Tytuł oryginału: Rectal cancer - functional outcome and quality of life.
    Tytuł polski: Rak odbytnicy - czynnościowe wyniki leczenia i jakość życia.
    Autorzy: Szczepkowski Marek
    Źródło: Proktologia 2002: 3 (2) s.162-174, tab., bibliogr. 25 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy było przedstawienie jakości życia pacjentów po operacjach z powodu raka odbytnicy. Przedstawiono analizę porównawczą pacjentów po brzuszno-kroczowej amputacji odbytnicy i chorych po przedniej niskiej resekcji z zachowaniem zwieraczy. W ocenie jakości życia chorych brano pod uwagę następujące elementy: a) funkcjonowanie organizmu i ogólny stan zdrowia (physical functioning); b) stan psychologiczny (psychologic functioning); c) sfera socjalna (praca zawodowa, relacje z osobami bliskimi - rodzina, znajomi, model wypoczynku i rozrywki) (social functioning); d) życie intymne (sexual functioning). W obu grupach pacjentów, zarówno po brzuszno-kroczowym odjęciu odbytnicy, jak i po przedniej niskiej resekcji odbytnicy, występuje znaczące obniżenie jakości ich życia. Pomimo że ogólny stan zdrowia pacjentów w obu grupach w większości przypadków jest dobry (u ponad 60 proc.), nieregularne wypróżnienia i biegunka występują często. Pacjenci ze stomią częściej zgłaszają problemy związane z niekontrolowanym oddawaniem gazów i problemy urologiczne, z kolei chorzy z zachowanymi zwieraczami skarżą się na zaparcia. Pacjenci ze stomią znacznie częściej skarżą się na depresję, poczucie osamotnienia, a nawet rozpaczy z powodu złej samooceny i poczucia niekorzystnej zmiany wyglądu własnego ciała. Poczucie to występuje zwłaszcza u młodych pacjentów, częściej u kobiet. Rak jelita grubego wywołuje zaburzenia socjalne, takie jak niechęć do podjęcia aktywności zawodowej po operacji, ...

    Streszczenie angielskie: The aim of this paper is to present the quality of life of patients operated on for rectal cancer. A comparative analysis of patients after abdominoperineal resection vs. patients after low anterior resection with preservation of sphincters is presented. When assessing the quality of life of patients, the following issues were considered; a) function of the whole organism and general condition (physical functioning); b) psychological well-being (psychological functioning); c) professional activity, relations with relatives and friends, leisure activities (social functioning); d) intimate relations (sexual functioning). In both groups of patients, both after abdominoperineal resection and after low anterior resection, a significant deterioration in the quality of life was noted. In spite of a good general health condition in the majority of cases (over 60 p.c. in both groups), frequent are irregular stools and diarrhoea. Stoma patients complain about uncontrolled passing of gas and urologic problems, while patients with preserved sphincter complain about constipation. Stoma patients significantly more often suffer depression loneliness and even despair due to low self-esteem and feeling of unfavourable change in body appearance. This feeling is present more often in younger patients and in women. Rectal cancer may cause social dysfunction, like reluctance to resume professional activity after surgery, limitation of socialcontacts, change of model of rest and leisure ...


    249/2523

    Tytuł oryginału: Current treatment of metastatic colorectal cancer.
    Tytuł polski: Aktualne sposoby leczenia nawrotów raka jelita grubego.
    Autorzy: Carrato Alfredo
    Źródło: Proktologia 2002: 3 (2) s.175-178, tab., bibliogr. 17 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Uważa się, że u ok. 50 proc. pacjentów ze świeżo rozpoznanym rakiem jelita grubego (CRC) dojdzie do powstania przerzutów, a 5-letnia przeżywalność wynosi 50 - 60 proc. Dla poprawy przeżywalności pacjentów z zaawansowanym rakiem jelita grubego konieczne jest wdrożenie paliatywnej chemioterapii i leczenia skojarzonego. Dawniej podstawą leczenia CRC w fazie przerzutów był 5-fluorouracyl (5-FU), najpierw w monoterapii, a następnie w połączeniu z innymi cytostatykami wg odpowiednich schematów. Ostatnio zastosowano połączenie 5-FU z bardziej aktywnymi nowymi preparatami. Jednym z nich jest irinotekan (inhibitor topoizomerazy), który może indukować odpowiedź terapeutyczną nawet w przypadkach odpornych na 5-FU. Oksaliplatyna (związek platyny) w połączeniu z 5-FU wydłuża czas przeżycia bez progresji, jednak bez istotnego wydłużenia mediany całkowitego czasu przeżycia. Analiza genetyczna, mająca na celu określenie molekularnych czynników rokowniczych, powinna pomóc w zdefiniowaniu grup pacjentów, którzy najbardziej skorzystaliby z określonej metody leczenia. W osiągnięciu tego celu może pomóc zindywidualizowana chemioterapia, prowadzona w oparciu o indywidualne cechy konkretnego pacjenta. Połączenie chemioterapii i immunoterapii, zastosowanie inhibitorów metaloproteinaz, czynników blokujących angiogenezę, czynników blokujących transdukcję sygnałów i terapia genowa pozostają na razie we wczesnej fazie badań, ale stanowią logiczne kierunki dalszego rozwoju metod leczenia.

    Streszczenie angielskie: 50 p.c. of newly diagnosed patients with colorectal cancer progress to metastatic disease with a 5-year survival of 50 - 60 p.c. There is need palliative chemotherapy in advanced CRS as well as adjuvant treatment to improve survival. In the past 5-fluorouracil has been the mainstream in metastatic CRC, initially as a monotherapy and then in conjunction with other agents in regimens. More recently 5-FU have been combined with active newer agents. One of them is irinotecan (topoisomerase inhibitor) which is capable of inducing response in-patients resistant to 5-FU. Oxaliplatin (platinum compound) in combination with 5-FU improved progression free survival without a significant increase in median survival time. Genetic analyses to help identify molecular prognostic factors should define more precisely which group of patients will benefit from a specific therapy. Customized chemotherapy based on each patient's individual features can help to attain thil goal. Combinations of chemotherapy with immunotherapy, metalloprotease inhibitors treatment, antiangiogenic agents, signal transduction inhibitors and gene therapy are early trials and are logical steps for future clinical development.


    250/2523

    Tytuł oryginału: Therapeutic approach of anal cancer.
    Tytuł polski: Metody leczenia raka odbytu.
    Autorzy: Karaitianos I. G., Maraghoudakis E. N.
    Źródło: Proktologia 2002: 3 (2) s.179-182, tab., bibliogr. 20 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Rak odbytu występuje rzadko. Nazwa ta odnosi się do najczęstszego nowotworu złośliwego okolicy odbytu - raka kolczystokomórkowego. Jest to jedyny nowotwór złośliwy przewodu pokarmowego, gdzie możliwe jest wyleczenie bez radykalnej operacji. Rak odbytu jest w większości przypadków chorobą miejscową, przerzuty odległe w chwili rozpoznania stwierdza się u mniej niż 10 proc. pacjentów. Nowotwory odbytu klasyfikuje się tak jak nowotwory skóry, w oparciu o system TNM. W leczeniu dąży się do miejscowego i regionalnego opanowania nowotworu, w miarę możliwości przy zachowaniu funkcji zwieraczy. Dostępne metody leczenia obejmują: leczenie chirurgiczne, radioterapię i skojarzoną radio- i chemioterapię. Resekcja brzuszno-kroczowa, będąca postępowaniem z wyboru w przypadku raków zlokalizowanych poniżej linii grzebieniastej, w coraz większym stopniu jest zastępowana przez radioterapię, dającą taką samą przeżywalność. Radioterapia jako monoterapia daje 5-letnią przeżywalność u powyżej 70 proc. Jeszcze korzystniejsze jest połączenie radio- i chemioterapii. Schematy leczenia obejmują podanie 5-fluorouracylu z mitomycyną albo z cisplatyną. Miejscowe wycięcie niewielkich nowotworów z 1-cm marginesem, nawet z objęciem części aparatu zwieraczowego, pozwala uzyskać 5-letnią przeżywalność u powyżej 80 proc. Resekcja brzuszno-kroczowa jest stosowana w przypadku braku skuteczności chemioterapii i w przypadku wznowy miejscowej.

    Streszczenie angielskie: Carcinoma of an anus is an uncommon disease, which refers to the commonest anal malignancy - squamous cell carcinoma. It remains the only carcinoma of GI tract curable without the need for definitive surgery. Anal cancer is predominantly a locoregional disease with fewer than 10 p.c. of patients having distant metastases at presentation. Tumors of anal margin are classified with skin tumors which is based on TNM stating. Treatment objectives include local and regional control over the tumor and maintenance of sphincter function when possible. The methods of treatment include surgery, radiotherapy and combined radio-chemotherapy. Abdominoperineal resection as a treatment of cancers located below dentate line is as a first intention treatment has been mostly replaced by radiotherapy with the same survival rate. Radiation treatment alone may lead to a 5-year survival rate in excess of 70 p.c. Combination of radio- and chemotherapy is even more beneficial. Treatment protocols involve administration of 5-fluorouracil with mitomycin or even better with cisplatine. Local excision of small carcinomas demonstrates over 80 p.c. 5-year survival rate obtained with 1 cm clear margin which may include part of sphincter apparatus. Abdominoperineal resection is reserved as salvage therapy fort he failure of prior chemotherapy and in local recurrences.


    251/2523

    Tytuł oryginału: Surgical achievements in Crohn's disease.
    Tytuł polski: Wyniki leczenia chirurgicznego choroby Crohna.
    Autorzy: Delaini G. G., Marinello P., Nifosi F., Carrara B.
    Źródło: Proktologia 2002: 3 (2) s.183-184, bibliogr. 6 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Postęp w dziedzinie chirurgicznego leczenia choroby Crohna dotyczy głównie rozwoju technik umożliwiających oszczędzenie jelita, zmniejszenie urazu operacyjnego i zachowanie zwieracza odbytu. Plastyka miejsca zwężenia (strikturoplastyka) wskazana jest w przypadku zmian miejscowych, zwężeń mnogich na długich odcinkach jelita, u pacjentów po przebytych resekcjach, w przypadku nawrotu zwężenia w miejscu zespolenia krętniczo-okrężniczego oraz w przypadku zwężenia dwunastnicy. Strikturoplastyka pozwala uniknąć mnogich, rozległych resekcji i późniejszego wystąpienia "zespołu krótkiego jelita". Stosowane techniki obejmują metody Heineckego-Mikulicza, Finneya oraz izoperystaltyczną strikturoplastykę bok-do-boku. U niektórych pacjentów z chorobą Crohna możliwe jest wykonanie zespolenia zbiornika krętniczego z odbytem. Zabiegi laparoskopowe szybko zyskują popularność w chirurgicznym leczeniu choroby Crohna, a ich zalety to dobry wynik kosmetyczny, szybki powrót do zdrowia, krótki czas hospitalizacji, rzadkie występowanie powikłań i mniejsze ogólne koszty leczenia. Mniejszy jest też uraz operacyjny i mniejsze ryzyko powstania zrostów.

    Streszczenie angielskie: New surgical achievements are especially related to bowel-sparing techniques, to reduction of surgical trauma and preservation of anal sphincter. Stricturoplasty is indicated in skin lesions, multiple strictures sited in long segments, in-patients with previous resection, recurrence of ileocolic anastomotic strictures, strictures of the duodenum. Stricturoplasty avaids multiple, broad resections and possible short bowel syndrome. Techniques employed include Heinecke-Mikulicz, Finney or side-to side isoperistaltic stricturoplasty. Ileal pouch anal anastomosis is feasible in selected patients with Crohn's disease. Laparoscopic procedures are diffusing rapidly in surgery for Crohn's disease, with good cosmetic results, faster recovery, shorter hospital stay, fewer complications and lower costs. Trauma is reduced and possibility to create adhesions is also reduced.


    252/2523

    Tytuł oryginału: Anal fistula.
    Tytuł polski: Przetoka okołoodbytnicza.
    Autorzy: Rosa G., Lolli P., Vicenzi L., Bottura D., Castellini C.
    Źródło: Proktologia 2002: 3 (2) s.185-187, tab., bibliogr. 8 poz., streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Chirurgiczne leczenie przetok odbytu oparte jest na identyfikacji głównego kanału przetoki i jej wtórnych odgałęzień. Konfigurację przetoki można określić poprzez znalezienie jej ujść - zewnętrznego i wewnętrznego - oraz przebiegu samego kanału. Absolutnie przeciwwskazane jest nacinanie zwieracza odbytu, jeśli nie została jednoznacznie określona konfiguracja przetoki. Autorzy przeprowadzili 751 operacji przetoki odbytu. Wśród nich było 64 proc. przypadków wysokiego odejścia odgałęzień wtórnych, co znacznie utrudniało leczenie. U 85 proc. pacjentów kanał przetoki przechodził przez zwieracze. Najczęściej wykonywanym zabiegiem była fistulotomia i fistulektomia, jeśli przetoka nie obejmowała aparatu zwieraczowego. Przecięcie zwieracza było odraczane poprzez założenie setonu u 51 proc. spośród 436 przypadków przetok przezwieraczowych. Autorzy nie stosują techniki przesunięcia płata. Przed zabiegiem u wszystkich pacjentów przeprowadza się badania manometryczne w celu określenia zakresu nacięcia zwieracza. Po zabiegu odsetek nawrotów wynosił 4,2 p.c., a nietrzymanie stolca występowało u 0.98 proc. pacjentów.

    Streszczenie angielskie: Surgical approach to anal fistulas has to be based on identification of main track and secondary extension. Track features come from identification of primary and secondary fistula opening and traject. It absolutely forbidden to cut sphincter when clear tract identification is lacking. Authors performed 751 fistula operations. Among them 64 p.c. had secondary high tracks, which makres the treatment more difficult. 85 p.c. patients had a fistula passingthough sphincters. The most performed operation was fistulatomy and fistulectomy if the fistula did not involve the sphincters. The sphincter cutting was delayed with seton in 51 p.c. of 436 transsphincteric fistulas. Authors do not practice advancement flap techniques. All patient are evaluated manometrically before the procedure to determine the extend of sphincter cut. Reported recurrence rate was 4.2 p.c. and incontinence in 0.98 p.c. of patients.


    253/2523

    Tytuł oryginału: Anual fissure - pathophysiology and management.
    Tytuł polski: Szczelina odbytu - patofizjologia i postępowanie.
    Autorzy: Pfeifer Johann
    Źródło: Proktologia 2002: 3 (2) s.188-189, streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Etiologia szczeliny odbytu pozostaje nieznana, jednak za najbardziej prawdopodobne przyjmuje się skojarzone działanie urazu, niedokrwienia i wady anatomicznej. W ostatnich dziesięcioleciach standardowym postępowaniem stała się sfinkterotomia boczne, z odsetkiem powikłań nie przekraczającym 5 proc. Leczenie zachowawcze polega na miejscowym stosowaniu toksyny botulinowej, blokerów kanału wapniowego i substancji uwalniających tlenek azotu. Zasada leczenia zachowawczego jest taka sama jak w przypadku leczenia chirurgicznego - zmniejszenie napięcia, ciśnienia i bólu w obrębie odbytu celem przyspieszenia gojenia. Sfinkterotomia chemiczna z zastosowaniem tlenku azotu stanowi korzystną alternatywę obarczoną niewielkim ryzykiem efektów niepożądanych i może być uznana za metodę z wyboru w leczeniu pacjentów ze szczeliną odbytu.

    Streszczenie angielskie: Etiology of anal fissure is not known, however trauma with ischemia in combination with the anatomical structure is the most likely one. In the last decader standard therapy is lateral sphineterotomy with less than 5 p.c. of complication rates. Conservative management involves botulinum toxin, calcium channel blocker or NO-donor substances topical application. The idea behind the conservative treatment is identical to radical approach - to diminish anal pressure and pain in odrer to speed up the healing. Chemical sphincterotomywith NO is a viable option with small side effects and can be considered the procedure of choice for patients with anal fissures.


    254/2523

    Tytuł oryginału: Surgery for incontinence. Role of artificial sphincter.
    Tytuł polski: Chirurgiczne leczenie nietrzymania stolca. Zastosowanie sztucznego zwieracza odbytu.
    Autorzy: Pfeifer Johann
    Źródło: Proktologia 2002: 3 (2) s.190-191, streszcz., rez.
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Uważa się, że ok. 1,5 proc. osób w populacji ogólnej cierpi z powodu nietrzymania stolca, a brudzenie bielizny występuje u ok. 5 proc. U pacjentów z nasilonym i nieodwracalnym nietrzymaniem stolca możliwości leczenia chirurgicznego są ograniczone. Poza operacjami polegającymi na przemieszczeniu mięśni duże nadzieje wiąże się z implantacjami sztucznego zwieracza (artifical bowel sphincter, ABS). Jest to urządzenie zbudowane z mocnego elastomeru silikonowego, wypełnione płynem i składające się z mankietu, pompy i balonu regulującego ciśnienie. Odsetek powikłań jest niewielki, a głównym problemem są zakażenia. Chirurgiczne leczenie nietrzymania stolca musi być zindywidualizowane i dostosowane do konkretnej sytuacji klinicznej. Duże nadzieje budzi zastosowanie systemu ABS, pod warunkiem, że uda się uniknąć zakażeń.

    Streszczenie angielskie: It is said that up to 1.5 p.c. of population suffer from fecal incontinence, with soiling rate up to 5 p.c. For patients with severe irreparable fecal incontinence the surgical options are limited. Besides muscle transfer operations implantation of artificial bowel sphincter is a promising technique. It consist of fluid-filled, solid silicone elastomer device built of: cuff, pump and pressure regulating ballon. The complication rates seem to be very low with predominant factor of infection. Surgical treatment of fecal incontinence must be tailored to individual patient although ABS system is a promising device if infection can be avoided.


    255/2523

    Tytuł oryginału: 7th Central Congress of Coloproctology and Viscerosynthesis Italian - Baltic Week, June 2-4, 2002, Kaunas, Lithuania. Abstracts, [programme].
    Źródło: Proktologia 2002: 3 (2) s.192-223, tab. - 7 Środkowoeuropejski Kongres Koloproktologii i Wiscerosyntezy - tydzień włosko - bałtycki Kaunas 02-04.06. 2002
    Sygnatura GBL: 313,572

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • streszczenie


    256/2523

    Tytuł oryginału: Implication of immunological abnormalities after adenotonsillotomy.
    Autorzy: Zielnik-Jurkiewicz Beata, Jurkiewicz Dariusz
    Źródło: Int. J. Pediatr. Otorhinolaryngol. 2002: 64 (2) s.127-132, tab., bibliogr. 20 poz.
    Sygnatura GBL: 306,189

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The adenoids and tonsils are thought to be essential parts of the system protecting organism against pathogens invading the upper respiratory tracts. Human adenoids and tonsils are known to be immunologically reactive lymphoid organs, which manifest specific antibodies and B and T cells activity in response to variety of antigens carrying out the functions of humoral and cellular immunity. The purpose of the study was to observe the changes in systemic immunity in children with hypertrophy of adenoids and tonsils treated in Department of Laryngology, Children's Hospital in Warsaw in period 1994-1999. The study comprised 80 patients (33 girls and 47 boys, aged from 3 to 14 years, mean age 6.8 years) with diagnosed hypertropphy of adenoids and tonsils. The diagnosis of hypertrophy of adenoids and tonsils was based on characteristic history and laryngological examination. All patients were scheduled for adenotonsillotomy. The control group comprised 40 people (14 girls and 26 boys, aged from 3 to 15 years, mean age 7.6 years) without hstory of the recurrent upper tract infections. In all patients we carried out following examinations: serum levels of immunoglobulins A, G, M (humoral immunity); percentage of T lymphocytes (CD3); percentage of T helper (CD4) and T cytotoxic (CD8) lymphocytes (cellular immunity) and delayed cutaneous hypersensitivity - Multitest CMI (cell mediated immunity). Our study demonstrate that in children with hypertrophy of adenoids and tonsils exist changes in the immunological parameters...


    257/2523

    Tytuł oryginału: Raccoon dog (Nyctereutes procyonoides) - the new host of Echinococcus multilocularis in Poland.
    Autorzy: Machnicka-Rowińska Barbara, Rocki Bogusław, Dziemian Ewa, Kołodziej-Sobocińska Marta
    Źródło: Wiad. Parazytol. 2002: 48 (1) s.65-68, tab., bibliogr. [14] poz.
    Sygnatura GBL: 303,658

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The alimentary canals of 9 species of domesticated or wild animals were examined for the presence of E. multilocularis. The tapeworm was found in 9 red foxes (Vulpes vulpes) out of 155 examined (5.8 p.c.) and in 2 raccoon dogs (Nyctereutes procyonoides) of 25 examined (8.0 p.c.). Our studies proved that in Poland the raccoon dog can also be infected with E. multilocularis.


    258/2523

    Tytuł oryginału: Early toxicity of combined treatment in localised and locally advanced prostate cancer: hormone therapy with conformal radiotherapy.
    Autorzy: Milecki Piotr, Stryczyńska Grażyna, Stachowski Tomasz, Kwias Zbigniew
    Źródło: Urol. Pol. 2002: 55 (2) s.48-52, bibliogr. 28 poz., streszcz.
    Sygnatura GBL: 304,054

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • onkologia
  • radiologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie polskie: Cel. Celem pracy była ocena wczesnej toksyczności skojarzonego leczenia (hormonoterapi + radioterapia konformalna 3D [3 d-CRT) u chorych z rakiem gruczołu krokowego. Materiał i metody. W okresie od kwietna 1999 roku do grudnia 2000 roku w Wielkopolskim Centrum Onkologii w Poznaniu 42 chorych z rakiem gruczołu krokowego (T1-T3N0M0) zostało leczeniu poddanych radioterapią konformalną 3D w skojarzeniu z hormonoterapią. Analizowana grupa chorych obejmowała następujące stopnie zaawansowania klinicznego: T1 = 4 chorych, T2 = 11 chorych, T3 = 27 chorych. U żadnego z poddanych analizie nie stwierdzono obecności przerzutów odległych. U wszystkich chorych przed rozpoczęciem leczenia napromienianiem, oraz w jego trakcie, zastosowano leczenie hormonalne, składające się z agonisty LHRH lub obustronnej orchidektomii w skojarzeniu z flutamidem. Leczenie napromienianiem prowadzono przy zastosowaniu fotonów 15 MV w dziennej dawce 1,8 Gy do średniej dawki całkowitej 71,7 Gy (67,8 - 72 Gy). Ostry odczyn popromienny był oceniany według klasyfikacji zaproponowanej przez Radiation Therapy Oncology Group (RTOG). Wyniki. Wszyscy chorzy ukończyli cały cykl napromieniania bez konieczności wprowadzania dodatkowych przerw z powodu nasilenia objawów ubocznych terapii. Do najczęstszych objawów ubocznych prowadzonego leczenia hormonalnego w analizowanej grupie zaliczono: "uderzenia gorąca", poty, powiększenie gruczołów piersiowych, uczucie dyskomfortu w jamie brzusznej. Wszystkie powyższe ...

    Streszczenie angielskie: Purpose: to evaluate acute toxicity of combined treatment (androgen ablation and 3D conformal radiotherapy [3D-CRT] in patients with localised and locally advanced cancer of the prostate. Materials and methods. Between April 1999 and December 2000, at the Wielkopolskie Cancer Centre in Poznan, 42 patients with prostate cancer (T1-T3 N0 M0) were treated with 3 D conformal radiation therapy and hormone therapy. Patients representeda localised disease (1 = 4 patients, T2 = 11 patients) and locally advanced disease (T3 = 27 patients). No patients had clinically detectable distant metastases. Neo-adjuvant androgen ablation therapy (LH-RH agonists or bilaeral orchidectomy and flutamide) was given to all patients. Radiotherapy was performed using 15 MV photons in the daily fraction of 1.8 Gy to the total median dose of 71.7 Gy (range, 67.8 to 72 Gy). Acute toxicities were evaluted according to the Radiation Therapy Oncology Group (RTOG) morbidity scoring scale. Results. All patients completed the entire course of radiotherapy and were assessable for evaluation of acute toxicities. The most common side effects of androgen ablation were "hot flushes", gynaecomastia, and slight discomfort in the abdomen, although these were of mild intensity. The main problems during irradiation and for a few weeks after the completion of radiotherapy were related to: - genito-urinary tract (rgency, nocturia, dysuria). Toxicities were as follow: grade 0 and 1: 80 p.c. of patients and grade 2: ...


    259/2523

    Tytuł oryginału: Expression of mRNA for cytokines (TNF-ŕ and IL-1ŕ) in human cytomegalovirus (HCMV) and hepatitis B virus (HBV) infections.
    Autorzy: Kasprzak A[ldona], Zabel M[aciej], Wysocki J., SeidelSurdyk-Zasada [Jolanta] J[oanna], Filipiak B[arbara]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.63-68, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • immunologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: The study was aimed at detecting cellular sources of transcripts for two cytokines, TNF-ŕ and IL-1ŕ in infection with human cytomegalovirus (HCMV) or hepatitis B virus (HBV). The studies were performed on paraffin sections of organs (liver, pancreas, spleen, lungs) obtained upon autopsy from a child decreased due to acute inborn HCMV infectio on paraffin secions of liver biopsy, obtained from a child with HCMV-induced chronic hepatitis, and of liver biopsies obtained from children with chronic type B hepatitis (n = 13). The classical in situ hybridization was applied with digoxygenin-labeled probes and amplification by the ImmunoMax technique. In HCMV infection, the most pronounced expression of mRNA for TNF-ŕ and II-1ŕ was detected in pancreatic islets (mainly in á cells) and, then, in a decreasing sequence, in liver (in macrophages and sinusoidal endothelial cells) and in lungs (in alveolar macrophages). No expression of the two cytokines was detected in the sinusoidal endothelial cells) and in lungs (in alveolar macrophages). No expression of the two cytokines was detected in the spleen. In HBV infection, weak expression of TNF-ŕ in the liver were observed, mainly in sinusoidal endothelial cells and in mcrophages as well as in hepatocytes. These results were confirmed by immunocytochemical experiments.


    260/2523

    Tytuł oryginału: Ontogeny of the expression of some catecholamine synthesising enzymes in the female porcine preoptic area.
    Autorzy: Sienkiewicz Waldemar
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.69-76, il., tab., bibliogr. 60 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • zarodki
  • Świnie

    Streszczenie angielskie: Ontogeny of the catecholaminergic system of the preoptic area (PA) was studied in various animal species including mice, rats, cats and lower vertebrates. Until now, there has been no data about development of catecholaminergic structures in the porcine PA. To study this problem, hypothalami from six groups of animals were collected. Three groups of foetuses (70, 84 and 112 days old) and three groups of female pigs (1 day, 10 weeks and 7 - 8 months old) were used. Nerve structures immunoreactive for the studied substances: tyrosine hydroxylase (TH), dopamine á-hydroxylase (DáH) and phenylethanoloamine-N-metylthransfrease (PNMT) were observed in different periods. In PA, TH-IR (immunoreactive) structures appeared before 70th day of foetal life, DáH-IR between 70th and 84th day of foetal live and PNMT-IR only in 10-week old and adult animals. In the PA of 70-day old foetuses, single smooth and varicose nerve fibres immunoreactive only to TH were found. In PA of 84-day old foetuses, additionally, single nerve cell bodies immunoreactive to TH were shown and some of them also contained immunoreactivity to DáH. In Pa of 1-day old piglets, moderate numbers of nerve fibres immunoreactive to TH and only single TH/DáH-IR nerve terminals were observed. TH-IR nerve cell bodies were also moderate in number and many of them contained simultaneously immunoreactivity to DáH. In PA of 10-week old pigs, a moderate number of immunopositive nerve fibres was observed. They contained mainly TH, but part of them stained also for TH/DáH. Only very few nerve fibres containing exclusively DáH were found...


    261/2523

    Tytuł oryginału: Proceedings of the conference "Flow cytometry and quantitative microscopy in medical diagnostics", May 21-22, 2001, Poznań, Poland.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.99-116, il., tab., bibliogr. [przy artyk.] - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    262/2523

    Tytuł oryginału: Decreased density of the CCR5 receptor on the surface of CD4+ lymphocytes and monocytes/macrophages is associated with the CCR5-59653T transition in the promoter region.
    Autorzy: Lewandowska M., Jagodziński P. P., Trzeciak W[iesław] H.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.101-102, il., bibliogr. 7 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We compared the denistity of the CCRS receptor on the surface of CD4+ lymphocytes and monocytes/macrophages ot the homozygote (CCR5-59653C) and the heterozygote (CCR5-59653T), bearing CCR-2-64V alleles. Flow cytometric analysis revealed lower density of the CCR5 receptor on the surface of CD4+ lymphocytes and monocytes/macrophages of the heterozygote than in the same cells of the homozygote. Our observation might explain slower replication of HIV and the delay in progression to AIDS in the individuals beraing CCR5-59653T transition.


    263/2523

    Tytuł oryginału: Reactivity of alveolar macrophages in lung cancer patients and healthy subjects: surface ICAM-1 after INF-ç stimulation in vitro.
    Autorzy: Hoser G., Grubek-Jaworska H., Droszcz P., Domagała-Kulawik J., Dąbrowska M., Chazan R.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.103-104, il., tab., bibliogr. 6 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The linearity of ICAM-1 expression on alveolar macrophages (AM) before and after INF-ç stimulation in healthy and lung cancaer subjects were compared. AM were collected by bronchoalveolar lavage and incubated with/without INF-ç according to standard procedures. The harvested calls were analyzed by flow cytometry using mooclonal antibodies against leucocytes and macrophages. Only viable cells were analyzed. Stimulation with INF-ç revealed two AM subpopulations of similar size differentiated in the intensity of ICAM-1 expression. They were not distinctly marked in every studied case. our preliminary results did not confirm the previously reported decreasing reactivity of AMs after INF-ç stimulation in lung cancer patients.


    264/2523

    Tytuł oryginału: DNA ploidy assessment method applied to primary breast carcinoma FNA biopsies.
    Autorzy: Czuba A., Lange D., Chmielik E., Wołoszyńska K., Wojciechowska E., Śnietura M., Liszka J.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.105-106, il., tab., bibliogr. 5 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The goal of our study was to assess suitability of FNA biopsy material as a source of samples (cell suspension) for DNA ploidy assessment in neoplastic tumors using flow cytometry. DNA ploidy is an established prognostic factor in many types of cancers. Aneuploid breast tumors are characterized by increased aggressiveness which manifests itself through rapid local progression and metastatic spread. Investigated specimens were breast cancer FNA biopsy cell susupensions. Measurements were performed using flow cytometry. Material studied comprised 143 cases analyzed in 1999-2000. We found in this group 101 carinoma cases with aneuploid typ and 42 cases of primary breast carcinoma with diploid type of cell cycle. Immunocytochemical assessment of estrogen receptor and progesterone receptor status was performed in group of 105 cases DNA ploidy was compared to receptor status of the invetigated cells. DNA aneuploidy correlated wtih weak or no reaction for the presence of estrogen and progesterone receptors. Our study demonstrates the suitability of DNA ploidy assessment method applied to cytological material from FNA biopsies.


    265/2523

    Tytuł oryginału: Fluorescence in situ hybridization (FISH) - application in research and diagnostics.
    Autorzy: Budny B., Kanik M., Latos-Bieleńska A[nna]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.107-108, il., bibliogr 10 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • niemowlęta
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The methods of molecular cytogenetics, in particular fluorescence in situ hybridization (FISH), are widely applied in cytogenetics for identification of numerical and structural chromosomal abnormalities, which are difficult to detect by routine cytogenetic techniques. Due to many advantages, FISH is used in research (gene mapping, gene expression studies, interspecies chromosome homology), and clinical diagnostics (chromosomal aberrations analysis in pre- and postnatal diagnostics, onclology). The techniques of in situ hybridization (ISH) are often employed in addition to classical banding techniques, in case where binding pattern is not reliable. This paper focusts on particular clinical examples, wher FISh was successfully used to identify structural and numerical chromosomal aberrations.


    266/2523

    Tytuł oryginału: The influence of photodynamic reaction on R2C cells.
    Autorzy: Wołuń-Cholewa M[aria], Warchoł J[erzy] B.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.109-110, il., bibliogr. 10 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Photodynamic therapy (PDT) represents a theapeutic approach in which photosensitised neoplastic cells undergo destruction under effect of light. In this study we have attempted to define effects of photochemotherapy R2C cells, sensitised with protoporphyrin IX (PpIX) and to find out whethe inhibition of gene expression by cycloheximide affects development of lesions in the cells. The photosensitised necrotic lesions was followed in the cells, using the fluorescent staining with propidium iodide and Hoechst 33342. The expresiments demonstrated that PpIX and light, acting in parallel, induce development of apoptotic and necrotic lesions in R2C cells. Intensity of the lesions correlated with concentration of the applied photosensitiser and with duration of light exposure. Using cycloheximide, we also inhibited protein expression in cells photosensitised with protoporphyrin before they were exposed to light. In the latter case, development of apoptosis was clearly intensified which might be explained by inhibition of antiapoptotic protein synthesis in the cells.


    267/2523

    Tytuł oryginału: Plasma membrane translocation of phosphatidylserine in human spermatozoa.
    Autorzy: Kotwicka M[ałgorzata], Jendraszak M., Warchoł J[erzy] B.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.111-112, il., bibliogr. 11 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The purpose of the study was to examine the phosphatidylserine translocation in human spermatozoa membrane during capacitation. Material consisted of human semen from normozoospermc men. Spermatozoa were stained with fluorescein-labelled annexin V. The presence and distribution of annexin V binding sites were analysed using the fluorescence micoroscope. Within first 60 min after ejaculation, 5 - 39 proc. viable annexin V-positive spermatozoa were detected. The annexin V binding sites were found mainl in the midpiece. After 4 to 8 h of incubation of spermatozoa in capacitation medium (BMI), the number of cells positively stained with annexin V increased. After capacitation, the localisations of phosphatidylserine was changed and the annexin V binding sites were found also in the acrosomal region but never in the equatorial area. The process of the phosphatidylserine translocation observed during our experiments may reflect changes of the plasma membrane occurring during capacitation or, less likely, apoptosis of spermatozoa.


    268/2523

    Tytuł oryginału: The influence of storage time upon the real thickness of the histological brain sections.
    Autorzy: Dziewiątkowski J[erzy], Spodnik J[anusz] H., Wójcik S., Spodnik E., Moryś J[anusz]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.113-114, il., bibliogr. 15 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The aim of the study was to assess the effect of storage time on the actual thickness of the histological sectons. The study was performed on 5 brains of adult Wistar rats. The most rapid changes occur at the beginning of the storage process, after about one month the dynamics of changes decreases, but still the thickness of the sections diminishes. It is suggested that quantitative analyses should be performed in similar period of time and the critical care should be taken not only of the chemicals and procedures used, but also of the control of environmental factors.


    269/2523

    Tytuł oryginału: Relation between the age of specimen and the shrinkage of brain frozen sections.
    Autorzy: Dziewiątkowski J[erzy], Wójcik S., Spodnik J[anusz] H., Spodnik E., Kowiański P[rzemysław, Moryś J[anusz]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.115-116, il., bibliogr. 13 poz. - Konferencja pt. Cytometria przepływowa i ilościowa, mikroskopia w diagnostyce medycznej Poznań 21-22.05. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: The aim of the study was to assess the effect of age of the animal upon the real thickness of the frozen sections. The study was performed on 19 rabbit brains. The thickness of the frozen sections regardless of their staining is age-dependent. The relation is proportional during the period from 7 to 180 postnatal day and characterizes both immunohistochemical as well as cresyl violet-stained sections; moreover, changes of the section thickness proceed parallely. It is suggeted that especially for some stereological parameters all required procedures should be standardized to achieve comparable and unbiasedly itnerprtable results.


    270/2523

    Tytuł oryginału: Proceedings of the 37th Symposium of the Polish Histochemical and Cytochemical Society, September 2-5, 2001, Cracow, Poland.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.117-234, il., tab., bibliogr. [przy artyk.] - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Polskie Towarzystwo Histochemików i Cytochemików


    271/2523

    Tytuł oryginału: Advances in immunocytochemistry.
    Autorzy: Noorden Susan Van
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.121-124, il., bibliogr. 20 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Recent advances in immunohisto/cytochemical methods have been directed towards new fluorescent labaels, and to increasing sensitivity and improving methods for multiple immunostaining. The newestfluorescent dyes come in many colours, are much mosre stable than fluorescein isothiocyanate and give brighter fluorescence. The greatest impact on sensitivity comes from heat-induced antigen retreival on paraffin sections. Biotinylasted tyramide can also increase enormously the amount of label on a preparation. The immunogold method with silver enhancement has been improved by nanogold, which is smaller than colloidal gold, attracts more silfer and increases the sensitivity even further. The difficulties of multiple labelling with two or more primary antibodies raised in the same species due to cross-binding between reagents have largely been overcome. There are new methods of blocking spare reactive sites on the first reaction by strong heat, e. g. from microwaving in buffer. Alternatively, one of the antibodis can be directrly biotinylated very easily with a new commercially available kit.


    272/2523

    Tytuł oryginału: Comparison of tchniques permitting to detect apoptosis in situ.
    Autorzy: Drąg-Zalesińska M[ałgorzata], Wysocka T[eresa], Dumańska M[ałgorzata], Jagoda E[wa], Zabel M[aciej]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.125-126, il., tab., bibliogr. 4 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Several morphological and biochemical techniques are inuse for identification of apoptotic and necrotic cells ina studied cell population. It is essential to define not only the type of cell death but also to identify the apoptotic process itself, which represents a multistage, active processes, requiring activation of a molecular event cascade. In the present study, we have examined and discussed effectiveness of the selected techniques detecting apoptosis in hymphocytes exposed to incubation at an elevated temperature. The appraisal involved detection of caspase-3 active form, detection of Bel-2, TUnel reaction, the comet assay and electrophoresis of DNA.


    273/2523

    Tytuł oryginału: Folia Histochemica et Cytobiologica
    Tytuł angielski: Correlation of histopathological and biochemical appraisal of anthracyclin-induced myocardium damage.
    Autorzy: Dzięgiel P[iotr], Surowiak P., Zabel M[aciej]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.127-128, il., bibliogr. 8 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • kardiologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Treatment of various tumor types with anthracyclin cytostatic drugs (DNR - daunorubicin and DOX - coxorubicin) is limited by their highe cardiotoxicity. This study was aimed at examining effectiveness of histopathological appraisal of myocardial cell injury induced by the cytostatic drugs and evaluated according to Bilingham and by MTS methods as compared to results of parallel biochemical assessment of lipid peroxidation indices (MDA - malonyldialdehyde, 4-HDA - 4-hydroxyalkenes). The experiments were performed on rats intoxicated with DNR or DOX in an acute manner (1 x 10 mg/kg body weight, i.v.) or a subchronic manner (3 x 3 mg/kg body weight i.v.). Significant positive correlations were demonstrated between results of histological and biochemical appraisal in rats intoxicated in the acute manner with DNR (r = 0.91), intoxicated in the subchronic manner with DNR (r = 0.90) and in rats intoxicated in the acute or subchronic manner with DOX (r = 0.91, r = 0.77, respectively). The obtained results have confirmed the free radical mechanism of cardiomyocyte injury induced by anthracyclines and the applied techniques of evaluating the destruction may be used independently of each other.


    274/2523

    Tytuł oryginału: Value of PCR technique in detection of Helicobacter pylori in paraffin-embedded material.
    Autorzy: Ciesielska U[rszula], Jagoda E[wa], Marciniak Z[ofia]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.129-130, il., tab., bibliogr. 6 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Methods which permit effective detection of Helicobacter pylori are based on endoscopic sampling of gastric mucosa followed by a direct or indirect demonstration of Helicobacter pylori bacilli, e.g. searching for specific proteins or gene fragments. PCR technique represents one ot techniques employed for diagnosing the biopsies. The present study was aimed at examining how effective is the detection of Helicobacter pylori in paraffin-embedded material by PCR technique using primers for the Ure C gene fragment. The material for studies involved gastric biopsies, routinely fixed in formalin and embedded in paraffin. In order to perfirm PCR, DNA was isolated and purified, subjected to amplification with the use of starters for the Ure C gene fragment. The performed experiments have confirmed suitability of PCR technique for detection of Helicobacter pylori.


    275/2523

    Tytuł oryginału: The dynamics of morphological changes in the pyloric endocrine cells of rats with uremia.
    Autorzy: Kasacka I[rena], Azzadin A[rsalen], Malla H.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.177-178, il., bibliogr. 14 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • gastroenterologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • płeć męska

    Streszczenie angielskie: Disturbances in renal homeostatic function lead to changes in endocrine cell secretory activity. The aim of this study was the histomorphological estimation of dependence of gastric APUD system cell morphology and function on the time after subtotal nephrectomy in Wistar rats. Fragments of gastric pylorus were collected 1, 2, 4, and 6 weeks after nephrectomy. Paraffin sections were stained with H+E and by silver impregnation. Immunohistochemical reactions with the use of specific antibodies against calcitonin gene-related peptide (CGRP), synaptophysin (SPh), somatostatin (ST), and neuron-specific enolase (NSE) were also performed. Immunoreactivity of the examined substances in the pyloric mucosa in the first week after nephrectomy was lowr than in the control group. However, in the following time intervals, endocrine cells showd stronger immunostaining in comparison with the control rats. The results suggest that chronic renal failure can modulate secretory activity of APUD system cells.


    276/2523

    Tytuł oryginału: Sequential translocation of tyrosine kinases Lyn and Syk to the activated Fcç receptors during phagocytosis.
    Autorzy: Strzelecka-Kiliszek A., Sobota A.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.131-132, il., bibliogr. 13 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Tyrosine phosphorylation of numerous proteins is one of the earliest events detectable during Fcç receptor-mediated phagocytosis. We demonstrate that IgG-coated particles associated with the surface of macrophages are enriched with numerous rytosine-phosphorylated proteins. During particle internalization the proteins are still associated with particles but their phosphorylation is reduced. Lyn kinase is phosphorylated both at particle binding and internalization steps. The phosphorylated Syk kinase is the major kinase associated with engulfed particles. Immunofluorescent studies confirm spatial and temporal distribution of Lyn and Syk kinases at different stages of phagocytosis. Our data indicate that ligation of Fcç receptors activites Lyn followed by Syk kinase and in the results multimolecular complex of the kinases and several accompanying tyrosine phosphorylated proteins with Fcç receptors is organized leading to local reorganization of actin-based skeleton and particle uptake.


    277/2523

    Tytuł oryginału: Efficiency of lipofection of adherent cells is limited by apoptosis.
    Autorzy: Bednarek I., Czajka M., Wilczok T.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.133-134, il., bibliogr. 10 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Stability of gene expression and transffection efficiency plays the main role in the application of gene transfere method. In somatic cell gene delivery, expression of the gene product is limite by the function of the cell to which it is delivered. In te present study analyzing the lipofected adherent cells, we have shown that lower level of transgene: á-galctosidase activite at later time period correlated with decrease in cell viability, which was shown to be due to apoptosis. Apoptosis following DNA uptake occurred only when DNA was present during lipofection.


    278/2523

    Tytuł oryginału: Effects of the combination of a proteasome inhibitor (PSI) and an inhibitor of ubiquitin-ligases (Leu-Ala) on the ultrastructure of human leukemic U937 cells.
    Autorzy: Biały Ł. P., Ziemba H[alina], Pleban E., Wójcik C[ezary]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.135-136, il., bibliogr. 14 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We have used the dipeptide Leu-Ala in an attempt to prevent the formation of ubiquitin-protein conjugates in U937 cells by inhibition of cellular E3 enzymes (ubiquitin ligases). Proteasome inhibitors induce the formation of perinuclear of ubiquitinated proteins and proteasomes (aggresomes) in the area of the proteolytic center of the cell. Leu-Ala did not prevent the formation of those aggregates under the action of PSI (peptidyl aldehyde, selective inhibitor of the chyotrypsin-like activity of teh proteasome), however it induced an accumulation of lipid droplets in treated cells, suggesting a previously unknown involvement of Leu-Ala in lipid metabolism. We conclude, that either Leu-Ala is not able to completely inhibit the cellular E3 enzymes or some of those enzymes are insensitive to this dipeptide, allowing therefore the build-up of ubiquitin-conjugates in the proteolytic centre of the cell.


    279/2523

    Tytuł oryginału: The effect of quercetin on the expression of heat shock proteins and apoptosis induction in monkey kidney cell line GMK.
    Autorzy: Jakubowicz-Gil J., Rzymowska J., Paduch R., Gawron A.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.137-138, il., tab., bibliogr. 10 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • małpy
  • in vitro

    Streszczenie angielskie: The present study was designed to investigate whether quercetin, a very common flavonoid widely distributed in many plants, can induce apoptosis in monkey kidney cells (GMK). Involvement of the expression of heat shock proteins Hsp72, Hsp3, Hsp27 and the significance of cell culture model in this process were also examined. The studies have shown that quercetin alone and in combination with the heat shock can induce apoptosis and necrosis in vitro in the sutided cells, but the percentagae of affected cells did not exceed 3.9 p.c. In the same experimental conditions, the expression of Hsp73, Hsp72 and Hsp27 increased in cells cultured in two-dimensional systm and decreased in three-dimensional model. This indicates that strong inhibition of heat shock proteins in GMK cells is not correlated with an adequate increase in the sensitivity of cells to undergo apoptosis. It also shows that the sensitivity of cells, manifested by Hsp expression and apoptosis induction, depends on the culture model and culture conditions.


    280/2523

    Tytuł oryginału: The expression of PDGF, its receptors and capillary morphometry in the developing lung: quantitative studies.
    Autorzy: Marszałek A[ndrzej], Biczysko W[iesława], Wąsowicz M[arcin], Daa T., Yokoyama S.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.139-140, il., bibliogr. 11 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • zarodki

    Streszczenie angielskie: The aim of the present study was the evaluation of the expression levels of PDGF-A and B, and PDGFR-ŕ, and changes of apillary cross-sectional areas during terminal vascular network formation in the developing lung. Pathogen-free fetuses and newborn Wistar rats were used. Lungs were processed for frozen sections used for immunohistochemical staining and parallel tissue specimens were prepared for transmission electron microscopy. The expression levels of PDGF-A and B, and PDGRR-ŕ were obtained using quantitative image anlysis. Additionally, the morphometry of capillary cross-sectional area was performed. We found that the expression levels of the studied antigens fluctuated, and the highest values were found in 2-day old fetuses (p 0.0001). Although there were no significant differences of the area of "a single" capillary, the area of the endothelium decreased significantly in perinatal period (p 0.0001). We conclude that the statistically significant changes of the studied antigens' expression as well as the of capillary cross-sectional area occur in the perinatal period.


    281/2523

    Tytuł oryginału: A search for colocalization of mGlu1a receptors with CRF or NPY in the rat brain amygdala.
    Autorzy: Śmiałowska M., Wierońska J. M., Wędzony K.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.153-154, il., bibliogr. 11 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Excitatory neurotransmitter glutamate, as well as corticoliberin (CRF) and neuropeptide Y (NPY) play an important roel in fear and anxiety. Among the brain structures engaged in these effects the important one is amygdala. In the present study, a single and double immunohistochemical staining techniques were used in order to visualize CRF, NPY and metabotropic glutamate receptors (mGluR1a) in rat amygdala. MGluR1a belongs to class of postsynaptic excitatory receptors and has a preferable somatic localization. CRF and NPY were localized using rababit polyclonal antibodies, and mGluR1a using a mouse monoclonal one. Then, ABC-peroxidase and DAB or benzidine were used. Upon single immunostaining, NPY and CRF were found in some nerve cell bodies and fibres in the amygdala. The immunoreactivity of mGluR1a was observed in some nerve cells, processes and fibres, especially on the border between the central and the basolateral nuclei and ventrally to that region. Double staining revealed mGlR1a-IR on some CRF- and NPY-immunoreactive nerve cell bodies and processes. The obtained results indicate that mGlu1a receptors may control at least some NPY and CRF neurons in the amygdala.


    282/2523

    Tytuł oryginału: The influence of interleukin-1 and interleukin-6 on expression of proteins involved in steroidogenesis in Leydig cells and on their apoptosis or necrosis in vitro.
    Autorzy: Sawiński P[iotr], Łukaszyk A[ndrzej]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.159-160, il., tab., bibliogr. 8 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia
  • urologia
  • endokrynologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: This paper presents a study on the expression of proteins involved in steroidogenesis in rat Leydig cells: StAR protein and aromatase, in relation to the age of animals and to the influence of interleukin-1 and interleukin-6. In addition, their effect on apoptotis and damage of Leydig cells was investigated. Leydig cells were isolated rom rats at certain age intervals and exposed to different concentrations of the above-mentioned cytokines. Next, total RNA was isolated from Leydig cells and RT-PCR with primers specific for rat StAR protein and aromatase was performed. The products were analysed by agarose gel electrophoresis. Leydig cells were also stained with propidium iodide and Hoechst 33342 to estimate the percentage of apoptotic or necrotic or necrotic cells.The results seem to confirm the role of interleukins in the control of expression of enzymes and regulatory factors involved in steroidogenesis in rat Leydig cells, and in the regulation of their apoptosis and necrosis. The effect of the studied interleukins on Leydig cells is exerted during development and after adolescence.


    283/2523

    Tytuł oryginału: Immunohistochemical localization of androgen receptors in testicular cells of mice with mosaic mutation.
    Autorzy: Kowal M., Kotula-Balak M., Styrna J., Bilińska B.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.161-162, il., bibliogr. 16 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Mice with mosaic mutation could be one of the models of human Menkes disease, which is associated with abnormal cooper metaolism. The aim of the present study was to localize androgen receptors (ARs) in the testes by means of immunohistochemistry. AR expression was observed in the nuclei of all somatic cells such as Leydig cells. Sertoli cells, and peitubular cells in sections from testes of control and mosaic mutant males. In the latter, very strong immunoreactivity for ARas well as higher levels of steroid hormones in homogenates were noticed in comparison to control mice. No positive immuoreaction for ARs was seen in control sections incubated without the primary antibody.


    284/2523

    Tytuł oryginału: Germ cells with nuclear DNA fragmentation related to apoptotic cells in rat testis in experimental hyperprolactinemia induced by metoclopramide.
    Autorzy: Laszczyńska M[aria], Słuczanowska-Głąbowska S[ylwia], Piasecka M[ałgorzata], Skowron J[oanna], Dębińska-Szymańska T.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.163-164, il., tab., bibliogr. 9 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The cells with nuclear DNA fragmentation related to apoptosis were detected by TUNEL technique in the seminiferous epithelium of control rats and of rats with experimental hyperprolactinemia induced by metoclopramide. The percentage of convoluted tubules with apoptotic cells and the number of apoptotic cells (predominantly spermatogonia and spermatocytes) was increased in the experimental group. The results indicated stage-specific germ cell apoptosis. In the experimental group, apoptotic cells were most evident at early (I-IX), middle (VII-VIII) and late (XII-XIV) stages of teh seminiferous epithelium cycle, as revealed by light and electron microscopy. We suggest that a decreased concentration of testosterone and an increased concentration of prolactin could disturb spermatogenesis and contribute to the intensive apoptosis of germ cell in rats with hyperprolactinemia. sertoli cells which have receptors for testosterone and prolactin and play an important role in spermatogenesis and in the initiation of apoptosis in seminiferous epithelium, could mediate such an influence of both hormones.


    285/2523

    Tytuł oryginału: New method of quantitative analysis of seminiferous epithelium in male guinea pigs.
    Autorzy: Surmacki P[iotr], Panasiuk J.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.165-166, tab., bibliogr. 3 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie
  • płeć męska

    Streszczenie angielskie: The aim of the study was the comparison of a newly developed method of quantitative analysis of the seminiferous epithelium (S) cells with the traditional method based on stage classification according to Clermont. In 4000 sections of seminiferous tubules the following parameters have been evaluated: in procedure I - the frequency of cells at the particular stages of the SE cycle, in procedure II - the frequency of particular cell types forming SE. In the two procedures, 17726 and 14670 cells were assessed, respecatively. In both procedures, the mean values of the studied cells per animal (I - 886.3 ń 15.4; II - 733.5 ń 93.9) and the distribution of the particular types of cells were similar. The new method of quantitative analysis is less laborious and cheaper. It may be applied instead of the method used so far.


    286/2523

    Tytuł oryginału: Temperature dependent hysteresis-like changes of motility parameters in hyman spermatozoa.
    Autorzy: Warchoł W[ojciech], Kotwicka M[ałgorzata]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.167-168, il., bibliogr. 5 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: We studied the imapct of temperture changes on selected parameters of normozoospermic spermatozoa motility. The examinations were carried out in the temperature range of 11řC to 21řC both during cooling and heating. We found that a phenomenon of hysteresis, i.e. alternate means of changes in velocity straight linear and lateral head displacement was obtained both at cooling and at heating. This phenomenon was not found for other parameters examined.


    287/2523

    Tytuł oryginału: Proteasome localization and ultrastructure of spermatozoa from patients with varicocele - immunoelectron microscopic study.
    Autorzy: Ziemba H[alina], Biały Ł. P., Frącki S[tanisław], Bablok L[eszek], Wójcik C[ezary]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.169-170, il., bibliogr. 16 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • in vitro

    Streszczenie angielskie: Localization of proteasomes in spermatozoa from patients with varicocele-associated sterility was studied by means of immunolabeling with the MPC21 monoclonal antibody detecting the C3 subunit of the 20S proteasome. The reaction was visualized for electron microscopy using the secondary Nano-Gold-coupled antibody with Gold-Enhancement in pre-embeding technique. We found that semen samples from varicocele patients contained a large amount of abnormal spermatozoa characterized by the presence of dispersed chromatin and large residual bodies (cytoplasmic droplets) as well as spermatids at various stages of spermiogenesis. In normal spermatozoa, the immunolabeling was found in the acrosome, postacrosomal regions, nuclear vacuoles, in the neck and in the middle-piece as well as in the residual bodies, while chromatin remained unlabeled. In varicocele spermatozoa, the immunolabeling was also associated with chromatin and large residual bodies (cytoplasmic droplets). In contrast to normal, mature spermatozoa, the chromatin of the cells at earlier stages of spermiogenesis was strongly immunolabeled. The association of proteasomes with sperm chromatin and large residual bodies can be the sign of abnormality and distrubances in spermatogenesis associated wtih varicoc\ele.


    288/2523

    Tytuł oryginału: Stages of the rat thymic medulla development in foetal period.
    Autorzy: Brelińska R[enata], Ostalska D[anuta], Kaczmarek E[lżbieta], Kowalska K[atarzyna]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.171-172, il., bibliogr. 6 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • zarodki

    Streszczenie angielskie: Development of thymic medulla was examined on consecutive gestational days (GD) in Wistar rats. Medullary thymic epithelial cells (TEC) were identified by immunocytochemical localisation of neuronspecific enolase (NSE). Organisation of thymic medullary architecture was determined by interaction of thymocytes with NSE-positive TEC, that led to formation of lymphoepithelial complexes (GD 19), in which the cells exhibited proliferative activity or traits of apoptosis. The studies indicated that differentiation events and organisation of thymic medulla require stagae-specific interactions between TEC and thymocytes.


    289/2523

    Tytuł oryginału: Age-related changes in rat thymic epithelial cells.
    Autorzy: Brelińska R[enata], Jaroszewicz A., Kowalska K[atarzyna]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.173-174, il., bibliogr. 10 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: We investigated age-related changes in immunocytochemical localisation of cytokeratin 16 (CK 16) in thymuses of female Wistar rats at various stages of adult life (months 1, 3, 6, 12). Within the 1 st month of life, distribution of CK typical for individual subsets of thymic epithelial cells (TEC) was observed. The most numerous CK16+ TEC were observed in the outer region of medulla, in the outer cells of Hasall's corpuscles and in the superficial epithelial layr neighbouring the connective tissue of the capsule, septa and vessels of the thymus. In the 3rd month of life, increased intensity of CK16 reaction in superficial TEC was accompanied by increased numbers of CK6+ TEC in the outer region of the medulla. Age-related alterations in the distribution of the studied markers were evident beginning from the 6rh month of life and involved increased expression of CK16 in the superficial layer of TEC, which at the interface with the septa formed startifed epithelium. In parallel, decreased numbers of CK16+ TEC distribution of a similar type developed in 12-month old rats and they probably relfected altered functions of some TEC populations and decreased or increased biological activity of other TEC populations.


    290/2523

    Tytuł oryginału: Lympho-epithelial interactions in rat thymus during pregnancy.
    Autorzy: Brelińska R[enata], Kowalska K[atarzyna], Paczkowska A., Jaroszewski J[an]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.175-176, il., bibliogr. 8 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Alterations in the thymic epithelial cell activity were analysed during pregnancy and lactation in Wistar rats by examining the presence and in situ distribution of lymphoepithelial complexes formed by thymic nurse cells (TNC). TNC were identified in paraffin sections by their exprssion of MHC class II antigens, CD54 molecule and a neuromarker, protein gene product 9.5 (PGP9.5). On the first days of pregnancy (gestational days, GD) the numbr of PGP9.5+ TNC was found to decrease abruptly. On GD14, a transient increase was noted in the number of PGP9.5+, MHC+, CD54+ TNC. Another increase was observed in the course of lactation, when the weight of the thymus reached the lowest values. While the increase in TNC numbers during lactation may be linked to the process of reconstruction of teh thymic lymphoid population, the augmented activity of lymphoepithelial interactions on GD14 may be associated with thymic engagement in pregnancy-induced immune processes.


    291/2523

    Tytuł oryginału: The dynamics of morphological changes in the pyloric endocrine cells of rats with uremia.
    Autorzy: Kasacka I[rena], Azzadin A[rsalan], Malla H.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.177-178, il., bibliogr. 14 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • płeć męska

    Streszczenie angielskie: Disturbances in renal homeostatic function lead to changes in endorine cell secretory activity. The aim of this study was the histomorphological estimation of dependence of gastric APUD system cell morphology and function on the time after subtotal nephrectomy in Wistar rats. Fragments of gastric pylorus were collected 1, 2, 4, and 6 weeks after nephrectomy. Paraffin sections were stained with H + E and by silver impregnation. Immunohistochemical reactions with the use of specific antibodies against calcitonin gene-related peptide (CGRP), synaptophysin (SPh), somatostatin (ST), and neuron-specific enolase (NSE) were also perforemd. Immunoreactivity of the examined substances in the pyloric mucosa in the first week after nephrectomy was lower than in the control group. However, in the following time intervals, endocrine cells showed stonger immunostaining in comparison with the control rats. The results suggest that chronic renal failure can modulate secretory activity of APUD system cells.


    292/2523

    Tytuł oryginału: Preliminary evaluation of pancreatic islets in rats with experimental uremia and after thyroparathyroidectomy.
    Autorzy: Kasacka I[rena], Azzadin A[rsalan], Sawicki B[ogusław]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.179-180, il., bibliogr. 13 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • gastroenterologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Hormonal disorders are the permanent symptoms of renal failure. They concern all known hormones and can be due to quantitative changes of the secretory activity and disturbances of endocrine cell functions. The aim of this study was to establish whether experimental thyroparathyroidectomy in uremic animals causes detectable histomorphological changes in endocrine cells of pancreatic islets. Thyroparathyroidectomy was performed in rats 30 days after nephrectomy. Fragments of pancreatic tissue were collected 14 days after the operation. Paraffin sections were stained with H + E and by silver salt impregnation. Immunohistochemical reactions were conducted using antibodies against calcitonin gene-related peptide (CGRP), synaptophysin (SPh), somatostatin (ST), neuron-specific enolase (NSE), and chromogranin (CgA). It was shown that endocrine cells of pancreatic islets in thyroparathyroidectomized rats show intensified immunoreactivity to SPh and ST as compared to the control group of animals. Immunocytochemical reactions for NSE, CgA, and CGRP were negative.


    293/2523

    Tytuł oryginału: Thyroid C cells in male and female rats with chronic renal failure.
    Autorzy: Kasacka I[rena], Azzadin A[rsalan], Malla H.
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.181-182, il., bibliogr. 14 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The kidneys are responsible for iodine and of thyroid hormone biodegradation. The aim of this study was the histomorphological and immunohistochemical evaluation of the influence of sex on parafollicular thyroid C cells in rats chronic renal failure. The experiment included 40 Wistar rats after subtotal nephrectomy, after sham operation, and without any surgical procedure. Two weeks after nephrectomy, fragments of thyroids were collected from the examined animals. Paraffin sections were stained with H + E and by silver impregnation. Calcitonin (CT), synaptophysin (SPh), somatostatin (ST), and neuron-specific enolase (NSE) were detected immunohistochemically in C cells. In rats with experimental uremia, immunostaining for the examined substances increased significantly in comparison to the controls. We also observed higher number of C cells with a stronger reaction in the group of males, compared to the female rats.


    294/2523

    Tytuł oryginału: Ultrasound and biochemical evaluation of liver regeneration process after resections for primary and metastatic tumors.
    Autorzy: Kulig Jan, Nowak Wojciech, Popiela Tadeusz, Sobocki Jacek, Zarębski Bartosz
    Źródło: Hepatogastroenterology 2002: 49 (44) s.349-353, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 304,355

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: background/Aims: The liver regeneration process after resective procedures is an important clinical problem especially in view of the growing population of patients requiring liver transplantations or undergoing resective procedures as well as those with toxic or viral liver injures. The aim of the study was to analyze liver regeneration potential using ultrasound examination, and liver function biochemical tests in the patients after liver resections. Methodology: Twenty-one patients with primary or metastatic liver cancer were included in the study (17 males, 4 females, mean age: 59.8, SD 10:3). The patients were undergoing gastrointestinal tract primary tumor resections with extended lymphandenectomy and liver metastatic tumor excisions. Liver volume was measured postoperatively in the follow-up ultrasound examinations and biochemical tests were performed before and after the procedure. Liver function and activity of p-450 cytochrome was tested with IRIS 13C stable isotope breath analyzer. Results: The mean time of follow-up was 12.6 months (SD 7.8) during which volume of liver increased on average in the first five months to 105.7, 112.1, 125.7, 131.2, and 138.4 p.c. of the immediate postoperative value. Biochemical parameters returned to normal after 2-3 weeks. Four patients in whom liver failed to regenerate died due to cancer spread in the mean time of 6.5 months. Conclusions: Liver has tremendous regeneration potential. In spite of this fact, extended hepatectomies affect largely the functionaln status of residual parenchyma which may lead to a fatal outcome.


    295/2523

    Tytuł oryginału: Chemokine growth-regulated-ŕ: a possible role in the pathogenesis of endometriosis.
    Autorzy: Szamatowicz J[acek], Laudański P., Tomaszewska I., Szamatowicz M[arian]
    Źródło: Gynecol. Endocrinol. 2002: 16 (2) s.137-141, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,072

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Endometriosis is a common disease in women at reproductive age. We investigated the concentration of neutrophil-activating factor (growth-regulated gene-ŕ, GRO-ŕ) (a member of the chemokine family), in peritoneal fluid of infertile women with or without endometriosis. Peritoneal fluid was obtained laparoscopically from 22 women with and 21 without visible endometriotic lesions. GRO-ŕ concentration was measured by the use of an ELISA kit. Median concentration of GRO-ŕ was 87.65 ń 56.19 pg/ml in the study group and 60.72 ń 11.98 pg/ml in the control group. The distribution of data differed from normal, therefore logarithmic transformation of data was performed. Concentration of GRO-ŕ was significantly higher in the peritoneal fluid of women with endometriosis when compared with controls (p = 0.05). No correlation between concentration of GRO-ŕ, stage of endometriosis, duration of infertility or sex steroid hormone levels was found. The study shows that GRO-ŕ may play a role in the pathogenesis of endometriosis, possibly by chemoattraction and activation of neutrophils present in higher numbers in the peritoneal fluid of women with endometriosis. It is also feasible that the angiogenic properties of GRO-ŕ might prompt the progression of endometriotic lesions.


    296/2523

    Tytuł oryginału: Clinical, electrophysiological and immunological remissions after thymectomy in myasthenia gravis.
    Autorzy: Kostera-Pruszczyk A[nna], Emeryk-Szajewska B., Świtalska J., Strugalska-Cynowska H., Rowińska-Marcińska K[atarzyna], Nowak-Michalska T., Szyluk B.
    Źródło: Clin. Neurophysiol. 2002: 113 (4) s.615-619, il., tab., bibliogr. s. 618-619
    Sygnatura GBL: 311,330

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objectives: Approximately 50 p.c. of patients treated with thymectomy have a chance for symptom-free life. However, immunological and neurophysiological abnormalities may be detected in patients with clinical remission. Although improvement usually parallels decrease in acetylcholine receptor antibody (AChRAb) levels and jitter values, there is a question what factors influence immunological and electrophysiological remission in a population of myasthenia gravis (MG) patients. Methods: We analyzed retrospectively clinical data of 32 MG patients operated for generalized MG, followed-up at our department for 17.2 (4-31) years. They were in clinical remission for 12.8 (2-25) years. All of them had single fiber electromyography (SFEMG) of extensor digitorum communis muscle (EDC) muscle and estimation of AChRAb level at the end of follow-up. Their age at onset of MG was 17 years (6-48) and at thymectomy 19 (6.4-58) years. Tensilon test was positive in 30, repetitive nerve stimulation in 29 cases. Results: Clinical remission was reached on average 4.2 years after thymectomy. SFEMG jitter value normalized in 60 p.c. of cases, AChRAb were negative only in 34 p.c. of patients. Jitter values correlated with AChRAb levels (P = 0.006,, r = 0.5) but were not related to clinical factors. Only time to thymectomy correlated with time from thymectomy to clinical remission (P = 0.001, r = 0.5). Conclusions: Clinical remission is not always accompanied by normalization of SFEMG and AChRAb. Although normalization of neuromuscular transmission in patients with remission of MG is individual, short duration of MG before thymectomy increases the chance of early remission.


    297/2523

    Tytuł oryginału: Asymmetry of frameshift mutagenesis during leading and lagging-strand replication in Escherichia coli.
    Autorzy: Gaweł Damian, Jończyk Piotr, Białoskórska Małgorzata, Schaaper Roel M., Fijałkowska Iwona J.
    Źródło: Mutat. Res 2002: 501 (1/2) s.129-136, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 304,952

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Mutations in DNA, including frameshifts, may arise during DNA replication as a result of mistakes made by the DNA polymerase in copying the DNA template strands. In our efforts to better understand the factors that contribute to the accuracy of DNA replication, we have investigated whether frameshift mutations on the Escherichia coli chromosome occur differentially within the leading and lagging-strands of replication. The experimental system involves measurement of the reversion frequency for several defined lac frameshift alleles in pairs of strains in which the lac target is oriented in the two possible directions relative to the origin of chromosomal replication. Within these pairs any defined lac sequence will be subject to leading-strand replication in one orientation and to lagging-strand replication in the other. Fidelity differences between the two modes of replication can be observed as a differential lac reversion between the two strains. Our results, obtained with a series of lac alleles in a mismatch-repair-defective background, indicate that for at least some of the alleles there is indeed a difference in the fidelity of replication between the two modes of replication.


    298/2523

    Tytuł oryginału: Decreased apoptosis and distinct profile of infiltrating cells in the nasal polyps of patients with aspirin hypersensitivity.
    Autorzy: Kowalski M. L., Grzegorczyk J., Pawliczak R., Kornatowski T., Wagrowska-Danilewicz M., Danilewicz M.
    Źródło: Allergy 2002: 57 (6) s.493-500, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 302,302

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • immunologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Patients with aspirin-hypersensitive rhinosinusitis/asthma suffer from a severe form of hyperplastic rhinosinusitis with recurrent polyposis. We aimed to assess the presence of apoptotic cells in nasal polyps from aspirin-hypersensitive (AH) and aspirin-tolerant (AT) patients with rginosinusitis as related to the characteristis of local inflammation. Methods: Nasal polyps obtained from 16 AH patients and 36 AT patients (17 atopic and 19 nonatopic) were stained for eosinophils and metachromatic cells, and in parallel immunocytochemistry was performed to detect CD45RO+, HLA-DR+, CD8+ and CD68+ positive cells. Apoptotic cells were detected by a nick-end labelling technique, TUNEL. Results: The density of apoptotic cells in AH polyps (5.5 + 1.5 cells/mmý) was significantly lower as compared to both atopic (18.7 + 3.8 cells/mmý; P 0.02;) and nonatopic (21.3 + 5.2 cells/mmý; P 0.01) AT polyps. The number of eosinophils, mast cells, and CD45RO+ cells weer significantly increased in AH compared to AT polyps () 0.001), and the density of HLA-DR+ cells in AH patients was higher than in nonatopic (P 0.02), but not in atopic AT patients. While in AH patients the duration of rhinosinusitis correlated inversely with the number of apoptotic cells (r = - 0.67; P 0.04), in contrast, in AT atopic patients the duration of rhinosinusitis showed positive correlation with apoptosis (r = 0.89; P 0.003). Conclusions: We conclude, that decreased apoptosis of inflammatory cells in nasal polyps from ASA-hypersensitive patients, reflects a distinct mechanism of local inflammation and may be related to persistence and severity of the disease in these patients.


    299/2523

    Tytuł oryginału: Eotaxin but not MCP - 3 induces eosinophil influx into nasal fluid in allergic patients.
    Autorzy: Górski P., Wittczak T., Walusiak J., Pałczyński C., Ruta U., Kuna P., Alam R.
    Źródło: Allergy 2002: 57 (6) s.519-528, il., bibliogr. 36 poz.
    Sygnatura GBL: 302,302

    Hasła klasyfikacyjne GBL:
  • immunologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacground: Eotaxin and MCP-3 (CC chemokines), owing to their preferential action on eosinophils, seem to be the very importance in the patophysiology of allergic rhinitis and asthma. The purpose of this study was to examine the effect of intranasally administered eotaxin and MCP-3 after specific allergen priming on the influx of inflammatory cells and their soluble mediators into the nasal mucosa. Methods: Eotaxin and MCP-3 have been applied intranasally at the increasing doses of 1, 5 and 10 ćg to allergic patients after priming. The 'nasal pool' technique was used. The cell count and biochemical parameters in nasal lavage were evaluated before 30 min, and 4 and 24 h after the challenge with chemokines. Results: Both eotaxin and MCP-3 induced the increase in clinical 'score' lasting till 24 h. Eosinophil influx into nasal mucosa after provocation with eotaxin was also obsrved. The challenge with MCP-3 did not induce any significant changes in nasal lavage fluid. Conclusions: Eotaxin is likely to play an important role in the pathogenesis of allergic conditions in humans. MCP-3 did not induce inflammatory cell influx into nasal mucosa. The role of this chemokine in the pathogenesis of allergic inflammation is difficult to assess and requires further research.


    300/2523

    Tytuł oryginału: Oral cavity as a potential source of gastric reinfection by Helicobacter pylori.
    Autorzy: Karczewska Elżbieta, Konturek Joanna E., Konturek Peter C., Cześnikiewicz Marta, Sito Edward, Bielański Władysław, Kwiecień Nina, Obtułowicz Wojciech, Ziemniak Witold, Majka Jolanta, Hahn Eckhart G., Konturek Stanisław J.
    Źródło: Dig. Dis. Sci. 2002: 47 (5) s.978-986, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 310,037

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Helicobacter pylori (Hp) is a common pathogen colonizing the a gastric mucosa, but some reports indicated that it may also be found in the oral cavity, which could serve as a reservoir of the bacteria and a source of gastric reinfection. Accordingly, we aimed to study whether the oral cavity, particularly gingival pockets, are colonized by Hp and whether it could be the source of gastric reinfection. We studied 329 patients with dyspeptic symptoms (257 with chronic gastritis, 15 with gastric ulcer. and 57 with duodenal ulcer). The [**13C]urea breath test (UBT), gastroscopy, and Hp culture from gastric biopsies were carried out, and material was collected from the oral cavity (gingival pocket) for bacteriological culture and genomic DNA studies. The serum was obtained for anti-Hp IgG and anti-CagA assays and saliva for anti-Hp IgA determination using the ELISA technique. bacteria in material from gingival pockets and biopsies from the corpus and antrum of stomach of 30 DU patients before and after Hp eradication were also examined by PCR technique, using primers specific for 16S rNA. All Hp-positive patients (276) were subjected to one week of triple therapy (omeprazole 2 x 20 mg twice a day, clarithromycin 2 = 500 mg twice a day, and metronidazole 2 x 500 mg twice a day). The measurements descrived above were then repeated at four weeks and six months. Bacterkilogical culture showed the prsence of Hp in the material from oral cavity in about 50 p.c. of patients, whereas UBT, used as a gold standard, revealed gastric Hp infection in about 84 p.c. of these patients...


    301/2523

    Tytuł oryginału: Functionally impaired TR mutants are present in thyroid papillary cancer.
    Autorzy: Puzianowska-Kuźnicka Monika, Krystyniak Agnieszka, Madej Agnieszka, Cheng Sheue-Yann, Nauman Janusz
    Źródło: J. Clin. Endocrinol. Metab. 2002: 87 (3) s.1120-1128, il., tab., bibliogr. 52 poz.
    Sygnatura GBL: 310,620

    Hasła klasyfikacyjne GBL:
  • genetyka
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: TRs are transcription factors that regulate cell proliferation, differentiation, and apoptosis. They are cellular homologs of the transcriptionally inactive viral oncogene v-erbA. We tested the hypothesis that the functions of TRs could be impaired in cancer tissues as a result of aberrant expression and/or somatic mutations. As a model system, we selected human thyroid papillary cancer, in which the most common abnormalities, RET/papillary thyroid cancer rearrangements (fusion of RET kinase domain to the activating domains of other genes), were found in 40-45 p.c. of cases. We found that the mean expression levels of TRá mRNA and TRŕ mRNA were significantly lower, whereas the protein levels of TRá1 and TRŕ1 were in cancer tissues than in healthy thyroid. Sequencing of TRá1 and TRŕ1 cDNAs, cloned from 16 papillary cancers, revealed that mutations affected receptor amino acid sequences in 93.75 p.c. and 62.5 p.c. of cases, respectively. In contrast, no mutations were found in healthy thyroid controls, and only 11.11 p.c. and 22.22 p.c. of thyroid adenomas had such TRá1 or TRŕ1 mutations, respectively. The majority of the mutated TRs lost their trans-activation function and exhibited dominant negative activity. These findings suggest a possible role for mutated thyroid hormone receptors in the tumorigenesis of human papillary thyroid carcinoma.


    302/2523

    Tytuł oryginału: Microtubule associated protein (Tau) gene variability in patients with frontotemporal dementia.
    Autorzy: Kowalska Anna, Takahashi Keikichi, Kozubski Wojciech, Tabira Takeshi
    Źródło: Folia Neuropathol. 2002: 40 (1) s.1-5, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • genetyka
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Frontotemporal dementia represents up to 10 p.c. of all dementias and is, next to Alzheimer's disease and Lewy body disease, the third most common cause of degenerative dementia. The term "frontotemporal dementia" covers a range of conditions, icluding Pick's diseases, frontal lobe degenration and dementia associated with motor neurone disease. Neuropathologically FTD is characterised by atrophy of the frontal and temporal lobes of the cerebral cortex, often with additional subcortical changes. Both familial and more frequently sporadic forms of FTD can be recognised. Recently, mutations in the microtubule-associated protein (tau) gene have been found in families with frontotemporal dementia and parkinsonism linked to chromoseme 17 (FTDP-17). The identification of mutations in the tau gene indicates that the protein plays a central role in the process of neurodegeneration. Epidemiology of frontotemporal dementias in Poland remains still unknown. A prevalence of tau mutations among Polish patients has not been established yet. Here, we report results of a mutational analysis of the tau gene among FTD patients. No pathogenic mutation was found in the analysed sample. The study confirmed that the frequency of tau mutations is very low and depends strongly on the clinical criteria used to select patients. Mutations in the tau gene account only for a small number of FTD cases with a clear autosomal dominant pattern of disease inheritance. Therefore there should exist additional genetic and non-genetic factors contributing to the pathogenesis of both familial (linked and non-linked to chromosome 17) and sporadic forms of FTD.


    303/2523

    Tytuł oryginału: The effect of thymus ubiquitin complex on neuropathological changes within the brain of pregnant rabbits with experimental model of antiphospholipid syndrome.
    Autorzy: Nowacki Przemysław, Ossowicka-Stępińska Jadwiga, Ronin-Walknowska Elżbieta
    Źródło: Folia Neuropathol. 2002: 40 (1) s.7-11, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • ciąża

    Streszczenie angielskie: The present study was designed to assess the impact of thymus ubiquitin complex (TUC) on morphological changes within the central nervous system (CNS) in pregnant rabbits with experimental antiphospholipid syndrome (APS). We also compared the intensity of neuropathological appearance and serological markers of the APS treated with the TUC. Post-mortem neuropathological investigations were done in 47 female New Zealand rabbits. The material was divided into 4 groups: Group I - 23 pregnant animals with APS; Group II - 7 pregnant rabbits with APS, treated with TUC; Group III - 7 pregnant rabbits without APS, treated with TUC; Group IV (the control one) - 10 pregnant animals without APS, intreated with TUC. The APS was induced by subcutaneous injections of cardiolipin. There were two main abnormalities within the CNS of pregnant rabbits, which could be a result of the APS: the thrombo-necrotic foci of nervous tissue, and perivascular or meningeal inflammatory infiltrates. It turned out that TUC application reduced the morphological abnormalities, but it did not eliminate them entirely. The number of cases with thrombo-necrotic changes was reduced by approximately 18 p.c., while perivascular infiltrates by 36 p.c. respectively. The TUC application did not influence the meningeal infiltration. The platelet count significantly increase (p 0.001), the activated partial thromboplastin time shortened (p 0.001), and the number of immunised animals, demonstrating positive immunofluorescence test, significantly decreased after the TUC administration...


    304/2523

    Tytuł oryginału: N-methyl-d-aspartate receptor-mediated processing of á-amyloid precursor protein in rat hippocampal slices: in vitro - superfusion study.
    Autorzy: Gordon-Krajcer Wanda, Salińska Elżbieta, Łazarewicz Jerzy W.
    Źródło: Folia Neuropathol. 2002: 40 (1) s.13-17, il., bibliogr. 26 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • in vitro

    Streszczenie angielskie: Abnormal proteolytic degradation of the á amyloid precursor protein (á-APP) may result in accumulation of potentially neurotix á amyloid (áA). The role of various receptors in the regulation of á-APP processing has been suggested. This study aimed to determine how NMDA receptors and Caý+ ions regulate proteolysis of á-APP in rat hippocampus in vitro. Adult rat hippocampal slices were superfused with NMDA-containing media, and immunoreactivity of soluble á-APP derivatives was detected in dialysates. Application of 100 ćM and 250 ćM NMDA for 20 min in Caý+-containing medium induced dose-dependent release of amino-terminal á-APP derivatives, and a fragment of Aá sequence, whereas carboxy-terminal fragments of á-APP were only slighty detected. This indicates activation of á-APP processing, and release of its soluble cleavage products. This effect was inhibited by NMDA receptor antagonist 1 ćM MK-801 and 100 ćM CPP in Caý+-free medium, thus indicating that NMDA receptors and calcium ions mediate proteolytic non-amyloidogenic degradation of the á-APP.


    305/2523

    Tytuł oryginału: Early infantile form of spinal muscular atrophy (Werdnig-Hoffmann disease) with prolonged survival.
    Autorzy: Borkowska Janina, Rudnik-Schoneborn Sabine, Hausmanowa-Petrusewicz Irena, Zerres Klaus
    Źródło: Folia Neuropathol. 2002: 40 (1) s.19-26, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: According to several previously used classifiaction systems, spinal muscular atrophy (SMA) type I has been characterised by an early onset ( 6 months), severe course (patients are never able to sit without support) and fatal prognosis (death before 2-4 years). We report 36 out of 349 SMA type I patients (10 p.c.) who had an onset before 6 months and never learnt to sit but sirvived at least beyond their fifth birthday, in spite of total immobility and frequent respiratory infections. These data support a classification avoiding age at death as a criterion. In the subgroup of type I with prolonged survival, there was no difference in life span between those individuals who had an onset of disease at birth or before and those with symptoms starting after 3 months. Life span may be related to the ability to withstand repeated respiratory insult, as several of the sibships with children affected by similar neuromuscular compromise showed discordant ages at death. "Chronic" SMA I and SMA II may represent overlapping phenotypes as our index patients with SMA I had a sib with SMA.


    306/2523

    Tytuł oryginału: Suicide muscle cell programme-apoptosis. Ultrastructural study.
    Autorzy: Fidziańska Anna
    Źródło: Folia Neuropathol. 2002: 40 (1) s.27-32, il., bibliogr. 20 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: To establish the ultrastructural criteria of suicide muscle cell programme-apoptosis we investigated the muscle biopsies of acute fatal spinal muscular atrophy (SMA) infants with gene survival motor neurone (SMN) exon 7 deletion. The muscle cell apoptosis was characterised by precisely sequential morphology of both cell nucleus and sarcoplasm. The most characteristic feature was the aggregation of nuclear chromatin initially into peripherally located ring and later into uniformly dense, dark masses. Accompanying features included sarcoplasmic condensation cell shrinking and fragmentation into multiple bodies. The coexistence of muscle cells at different stages of apoptosis in the same tissue section was the most prominent and specific features of suicide muscle cell progarmme. The appearance of an identical sequence of ultrastructural changes in muscle as observed in other tissues suggesrs that a unique mechanism is involved in genetically programmed cell death.


    307/2523

    Tytuł oryginału: CT angiography in the diagnosis of spontaneous extracerebral vertebral artery dissection.
    Autorzy: Pniewski Jarosław, Woźniak Radosław, Chodakowska-Żebrowska Małgorzata, Sikorska Jolanta, Walecki Jerzy
    Źródło: Folia Neuropathol. 2002: 40 (1) s.33-37, il., bibliogr. 20 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Spontaneous vertebral artery dissection is an underrecognised cause of cerebral ischaemia, most often seen in young adult patients. For this diagnosis cerebral angiography is the most sensitive and specific method. We describe a 30-year0old, male, with cerebrallar stroke, in whom spontaneous vertebrak artery dissection was diagnosed. Our diagnosis was confirmed by cerebral angiography and CT angiography. In our case anticoagulation (in acute phase) was introduced subcutaneously and later continued orally. The outcome was very good with complete remission. CT angiography seems to be a promising non-invasuve method for the diagnosis of vertevral artery dissection. The prognosis in the patient with this diagnosis is relatively good (if managed properly), but the disease must always be treated as serious and life-threatening.


    308/2523

    Tytuł oryginału: Early occurring neuronal migration and maturation disorders.
    Autorzy: Dąmbska Maria
    Źródło: Folia Neuropathol. 2002: 40 (1) s.39-42, il., bibliogr. 6 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • płeć męska

    Streszczenie angielskie: This case report presents severe malformations of the central nervous system as a result of a pathological process occurring very early during development. Abnormal maturation and migration of neuroblasts were seen in all cerebral structures. Such changes are most often genetically determined, but in our case the analysis of their aetiology was not available.


    309/2523

    Tytuł oryginału: In memory of Professor Hanna Jędrzejowska [1930-2001].
    Autorzy: Dąmbska Maria
    Źródło: Folia Neuropathol. 2002: 40 (1) s.43-44, il. 2002
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Jędrzejowska
  • Hanna 1930-2001


    310/2523

    Tytuł oryginału: In memory of Professor Mirosław Mossakowski [1929-2001].
    Autorzy: Dąmbska Maria
    Źródło: Folia Neuropathol. 2002: 40 (1) s.45-46, il.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Mossakowski
  • Mirosław 1929-2001


    311/2523

    Tytuł oryginału: Salvage hemipelvis radiotherapy with fertility preservation in an adolescent with recurrent vulvar carcinoma.
    Autorzy: Serkies Krystyna, Wysocka Barbara, Emerich Janusz, Hrabowska Maria, Jassem Jacek
    Źródło: Gynecol. Oncol. 2002: 85 (2) s.381-383, bibliogr. 10 poz.
    Sygnatura GBL: 305,822

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background. To preserve fertility, hemi-pelvis irradiation was chosen for locoregional groin recurrence of vulvar cancer in an adolescent. Case. A case of squamous cell vulvar carcinoma in uncommonly young patient is presented. First surgical management (local excision of T1N0M0 tumor of the right labia minora) was performed at the age of 16.5 years. Further therapy included wide local resection of recurrent local lesion, two subsequent ipsilateral groin dissections of nodal metastases (with extranodal spread at the first instance), and ipsilateral pelvic lymphadenectomy. The patient was administered external beam irradiation of 45 Gy to the hemipelvis followed by 10.8 Gy boost to the right inguinal region. After 6.5 years from the completion of radiotherapy the patients is free of disease. She managed to conceive but the labor was premature and the infant died in its 7th week pf life. Conclusion. In this case salvage hemi-pelvic irradiation for groin metastases of vulvar cancer has proved to be an effective treatment, allowing preservation of hormonal and obstetric functions. Partial post-irradiation damage of the uterus might have caused premature labor. Thus, special obstetric care is advisable in such situations.


    312/2523

    Tytuł oryginału: Expression of the multidrug resistance-associated protein (mrp) gene in chronic lymphocytic leukemia.
    Autorzy: Juszczyński Przemysław, Niewiarowski Wojciech, Krykowski Euzebiusz, Robak Tadeusz, Warzocha Krzysztof
    Źródło: Leuk. Lymphoma 2002: 43 (1) s.153-158, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In order to define more accurately the role of multidrug resistance (MDR)-related protein (mrp) gene in chronic lymphocytic leukemia (CLL), we addressed the question of its expression pattern in isolated peripheral blood B lymphocytes in seven healthy donors and 28 patients with CLL, with respect to some laboratory and clinical parameters of the disease. For this purpose, we used a semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR), based on the coamplification of an internal standard not homologous to the DNA target to quantify the mrp transcription level in each studied sample. We report that the level of constitutive mrp gene's expression in peripheral blood lymphocytes is higher in CLL patients than in healthy controls. We found increased mrp gene expression levels in patients with higher white blood cells (WBC) and lymphocytes' counts as well as in more advanced disease stages according to Rai or Binet scale. Finally, mrp gene's expression was higher in patients with progressive CLL, especially in cases refractory to chemotherapy salvage. The results of the present study suggest that expression of mrp gene might be relevant in the pathogenesis of the MDR phenotype in CLL.


    313/2523

    Tytuł oryginału: The role of nucleoside analogues in the treatment of chronic lymphocytic leukemia-lessons learned from prospective randomized trials.
    Autorzy: Robak Tadeusz
    Źródło: Leuk. Lymphoma 2002: 43 (3) s.537-548, il., tab., bibliogr. 78 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The newer purine nucleoside analogues (PNA), fludarabine (FAMP) and cladribine (2-chlorodeox-yadenosine, 2-CdA) have been synthesized recently and introduced into the treatment of chronic lymphocytic leukemia (CLL). The results of large phase II studies indicate that FAMP and 2-CdA are similarly active in CLL. Unfortunately, no prospective randomized study comparing the results of the treatment of CLL patients with FAMP and 2-CdA has been published so far. Significantly higher overall response (OR) and complete remission (CR) in patients treated initially with PNA than with chlorambucil or cyclophosphamide based combination regimens has been recently confirmed in five prospective multicentre randomized trials. These studies have also shown longer response duration in patients treated with PAN than with conventional chemotherapy. Overall survival progression free and events free survival were similar in patients treated with ONA and with chlorambucil or other alkylating agent based regimens. However, the majority of randomized trials were designed as cross studies and most patients, treated with conventional chemotherapy were given PNA when refractory or in early relapse, which may influence the survival time. The results of a randomized study have shown a higher incidence of neutropenia and infections in patients treated with PNA than with chlorambucil. However, the frequency of autoimmune hemolytic anemia, pure red cell aplasia, secondary neoplasms and Richter's syndrome seems to be similar in patients treated with PNA and standard alkylating agents based chemotherapy...


    314/2523

    Tytuł oryginału: Intercalation of imidazoacridinones to DNA and its relevance to cytotoxic and antitumor activity.
    Autorzy: Dzięgielewski Jarosław, Ślusarski Bartłomiej, Konitz Antoni, Składanowski Andrzej, Konopa Jerzy
    Źródło: Biochem. Pharmacol. 2002: 63 (9) s.1653-1662, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 304,395

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Imidazoacridinones (IA) are a class of antitumor agents which includes C-1311, an interesting drug in clinical trials. This study investigated the mechanism of IA binding to DNA for a series of 13 analogs that differ in their cytotoxic potency. Using C-1311 as a model compound, crystallographic, spectroscopic and biochemical techniques were employed to characterize drug-DNA interactions. X-ray crystallographic analysis revealed a planar structure of imidazoacridinone core that is capable of intercalative DNA bibding. Accordingly, C-1311 binding to DNA followede "classical" pattern observed for intercalation, as proved by tha DNA topoisomerase I - unwinding experiments, with relatively weak binding affinity (Ki = 1.2 x 10**5 M-1), and the binding site size of 2.4 bp. Other IA also bound to DNA with the binding affinity in the range of 10**5 M-1 and binding site size of 2-3 bp, suggesting a prevalence of the intercalative mechanism, similar to C-1311. Considerable DNA binding affinity was displayed by all highly cytotoxic derivatives. However, none of the analyzed drug-DNA binding parameters was significantly correlated with IA biological activities such as cell growth. DNA and RNA synthesis inhibition, or tumor growth inhibition, which suggests that the IA ability to non-covalently bind to DNA is not crucial for their biological activity. These results show that the ability to intercalate into DNA is a prominent attribute of IA, although factors other intercalative binding seem to be required for the biological activities of IA drugs.


    315/2523

    Tytuł oryginału: Inhibition of gluconeogenesis by vanadium and metformin in kidney-cortex tubules isolated from control and diabetic rabbits.
    Autorzy: Kiersztan Anna, Modzelewska Aleksandra, Jarzyna Robert, Jagielska Elżbieta, Bryła Jadwiga
    Źródło: Biochem. Pharmacol. 2002: 63 (7) s.1371-1382, il., tab., bibliogr. 75 poz.
    Sygnatura GBL: 304,395

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Effect of vanadyl acetylacetonate (VAc) and metformin on gluconeogenesis has been studied in isolated hepatocytes and kidney-cortex tubules of rabbit. Glucose formation from alanine + glycerol + octanoate, pyruvate or dihydroxyacetone was inhibited by 50-80 p.c. by 100 ćM VAc or 500 ćM metformin in renal tubules of control and alloxan-diabetic animals, while the inhibitory action of these compounds in hepatocytes was less pronounced (by about 20-30 p.c.). In contrast to VAc, metaformin increased the rate of lactate formation by about 2-fold in renal tubules incubatet with alanine + glycerol + octanoate. In view of VAc-induced changes in intracellular gluconeogenic intermediates and gluconeogenic enzyme activities, it is likely taht this compound may decrease fluxes through pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and glucose-6-phosphatase. In contrast to VAc, metformin-induced decrease in renal gluconeogenesis may result from a decline of cytosolic oxaloacetate level and consequently PEPCK activity. Following 6 days of VAc administration (1.275 mg V kg-1 body weight daily) the blood glucose level in alloxan-diabetic rabbits was normalised while blood glucose changes in control animals were not observed. On the contrary, in diabetic animals treated for 6 days with metformin (200 mg kg-1 body weight day -1) a high blood glucose level was maintained. Unfortunately, VAc-treated control and diabetic rabbits exhibited elevated serum urea and creatinine levels. In VAc-treated animals vanadium was accumulated in kidney=cortex up to 7.6 ń 0.6 ćg V g-1 dry weight. In view of a potential vanadium nephrotoxicity...


    316/2523

    Tytuł oryginału: Components of the IFN-ç signaling pathway in tumorigenesis.
    Autorzy: Blanck George
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.151-158, il., bibliogr. 78 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Many features of the interferon ç (IFN-ç) signaling pathway would suggest that it is anti-tumorigenic. The IFN-ç signaling pathway leads to apoptosis and to the expression of immune function proteins that could cooperate with T cells in the destruction of tumor. Various lines of experimental approach have, in general, supported the hypothesis that the IFN-ç signaling pathway is anti-tumorigenic. However, data also indicate that the idea that the IFN-ç signaling pathway is exclusively anti-tumorigenic is too simplastic. Also, to date, very ;ittle of the knowledge regarding the anti-tumor effects of the IFN-ç pathway has been useful in the prognosis or therapy of cancer. This review summarize the current state of knowledge regarding the IFN-ç signaling pathway in tumorigenesis, with an emphasis on MHC class II induction in tumor cells and the induction of apoptosis in tumor cells. The review also indicates some future areas of investigation that offer hope for applying this knowledge in reducing cancer nortality.


    317/2523

    Tytuł oryginału: Modulation of pulmonary innate immunity during bacterial infection - animal studies.
    Autorzy: Schultz Marcus J., Poll Tom van der
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.159-167, il., tab., bibliogr. 68 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Both the increasing number of immunocompromised patients susceptible to pneumonia and the development of bacterial resistance are sgnificant problems related to the treatment of pneumonia. The primary outcome of treatment for pneumonia is to tip tha balance a successful host response. An ideal approach would be a combination of immunomodulayion and conventional antimicrobial therapy. It is of increasing imoprtance to understand the components of innate immunity, before immunomodulatory therapy can be applied to patients. Much of our knowledge of the role of alveolar macrophages, cytokines and chemokines in the pathogenesis of pneumonia is derived from animal studies on experimental pneumonia. This article summarizes current information on the role of an alveolar macrophage (AM) and AM-derived mediators in host defense against pneumonia.


    318/2523

    Tytuł oryginału: CD28 costimulatory molecule - expression, structure and function.
    Autorzy: Boćko Dorota, Kosmaczewska Agata, Ciszak Lidia, Teodorowska Renata, Frydecka Irena
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.169-177, il., bibliogr. 94 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: T cell activation is a key in triggering an antigen specific immune response of the organism. The process is induced primarily by the signal generated by direct interaction of a T cell receptor with an antigen bound to the major histocompatibile complex on an antigen-presenting cell (APC). Although the signal is critical in exciting immune response, an additional, costimulating signal is required. The major second signal is generated by interaction of the CD28 molecule expressed on most T lymphocytes with its natural ligands CD80 and CD86 located on APCs. The signal excited by CD28 triggering involves multiple second-messenger cascades, leading to the activation of transcription factors and finally results in cell proliferation, cytokine production, and the generation of effector functions. The importance of CD28-delivered costimulatory signals was proven in experiments with CD28-deficient mice. T cells from these mice exhibited an impaired pattern of cytokine secretion and defects in T cell-dependent antibody production. Certain forms of immunopathology might result from the aberrant regulation of CD28 expression.


    319/2523

    Tytuł oryginału: Mast cells and inflammation.
    Autorzy: Stassen Michael, Hltner Lothar, Mller Christian, Schmitt Edgar
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.179-185, bibliogr. 52 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Mast cells have long been recognized as potent producers of a large panel of biologically highly active mediators such as biogenic amines, arachidonic acid metabolites, cytokines and chemokines, but most of their biological functions have been elusive speculative. By taking advantage of mast cell-deficient mice, the role of mast cells in a variety of experimental settings can now studied in detail and such approaches have dramatically altered and enlarged our knowledge about mast cell biology and function. Herein we will focus on the role of mast cells in inflammatory reactions of diverse origin, such as delaved type hypersensitivity, atopy, immune complex-mediated inflammation and innate immune responses. From the current standpoint, there is no doubt that the most outstanding and beneficial feature of mast cells is their recently discovered ability to induce a life-saving inflammatory response rapidly upon encountering microbes and microbial constituents. Nevertheless, the picture is also emerging that mast cells are deeply involved in the induction and maintenance of a variety of severe allergic and autoimmune diseases. However, a deeper understanding of their activation and immune-modulatory capacity might open a new window for the development of curative strategies.


    320/2523

    Tytuł oryginału: The role of dendritic cells in neurodegenerative diseases.
    Autorzy: Iribarren Pablo, Cui You-Hong, Le Yingying, Wang Ji Ming
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.187-196, il., bibliogr. 92 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) involved in the induction of adaptive immune responses. The presence of DCs in the central nervous system (CNS) and the active participation of the immune system in a variety of neurodegenerative diseases have been demonstrated. This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states.


    321/2523

    Tytuł oryginału: Active vaccination after allogeneic bone marrow cell transplantation: a new option in the immunotherapy of cancer?
    Autorzy: Z”ller Margot, Matzku Siegfried
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.197-224, bibliogr. 456 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The concept of immunotherapy of cancer was evoked more than a century ago by W. Coley. Yet it is only recently that the state of knowledge allows for molecularly defined therapeutic approaches and much effort will still be required to place immunotherapy beside of surgery, chemotherapy and radiation as a fourth option. In this review, we will focus chiefly on two aspects: active therapeutic vaccination, because it is our belief that this approach will provide a major breakthrough, and the potential efficacy of combining active vaccination with allogenic bone marrow cell transplantation. It was recently established in clinical trials that allogenic bone marrow cell transplantation does not require myeloablative conditioning. Non-myeloabaltive conditioning which avoids the high toxicity of the conventional approach, it is only kind which allows the recruitment of elderly patients and patients in poor health. Concerning active vaccination protocols, we will address the questions 1) what the targets (i.e. the Antigens) of immunotherapeutic approaches could be; 2) how to achieve an optimal confrontation of the immune system with these tumor-associated antigens; and 3) which response elements are needed for raising a therapeutically successful immune reaction against these antigens. Many question remain to be answered in the field of allogeneic bone marrow transplantation after non-myelablative conditioning to optimize the therapeutic setting for this, most likely, very powerfull tool of cancer therapy. We will briefy summarize current considerations to improve engraftment...


    322/2523

    Tytuł oryginału: A two step procedure to fractionate mouse testicular macrophages with different cytokine profiles.
    Autorzy: Bryniarski Krzysztof, Szewczyk Katarzyna, Ptak Maria, Bobek Małgorzata, Ptak Włodzimierz
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.225-229, tab., bibliogr. 15 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • urologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Cells isolated enzymatically from the interstitial tissue of mouse male gonads are composed of macrophages, Leydig cells, and myofibroblasts. They can be separated on density gradients, either by sedimentation (Ficoll) or flotation (Percoll) into several fractions according to the different buoyant densities of the different cells in the mixture. Macrophages (FcçR+, esterase+) present in cell mixtures can by highly enriched (to 95 p.c. purity) in a single step by rosetting with opsonized erythrocytes followed by sedimentation on Lymphoprep. Separate fractions of highly purified (over 95 p.c.) macrophages obtained by the successive use of density gradients and rosetting differ significantly in the production of cytokines, e.g. cells from fractions at lower density produce little IL-6, cells from fractions at higher density are poor producers TNF-ŕ, while testicular macrophages (TMf) in intermediate fractions produce significant amounts of both cytokines. These differences may suggest that particlar subpopulations of testicular macrophages play different biological roles in the testis.


    323/2523

    Tytuł oryginału: Testing for aspirin hypersensitivity.
    Autorzy: Bochenek G., Niżankowska E[wa], Szczeklik A[ndrzej]
    Źródło: Allergy 2002: 57 (7) s.562-565, bibliogr. 33 poz.
    Sygnatura GBL: 302,302

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • immunologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    324/2523

    Tytuł oryginału: Influence of vitamins C and E on cytotoxic activity of adriamycin in chosen cell cultures.
    Autorzy: Woźniak Grażyna, Anuszewska Elżbieta L.
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.31-35, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Influence of different concentratioons of ascorbic acid (vitamin C) and dl-ŕ-tocopherol acetate (vitamin E) on in vitro cytotoxic adriamycin activity, in: embryonic human fibroblasts (CLV102), human melanoma cells (ME18) and adriamycin-resistant subline cells (ME18/R), was studied. IC50 value for each compound (compound concentration in the culture medium, for which 50 p.c. of cells survive) was determined. Cells' survival after the used agent was examined with trypan blue test. The relationship between different concentrations of vitamin C and toxicity of adiamycin, used at appropriate IC50 concentrations, was expressed for all the examined cells as their survival decrease, being in direct proportion to the concentration increase of this vitamin in the medium. In the case influence of vitamin E on adriamycin, the protective effect of this vitamin was observed in the concentration range: from 5 to 300 ćg/ml (p ó 0,0001), as an increase of the examined cell survival for ME18, ME18/R as well as for CLV102, comparing to the control (p = 0.05) without this vitamin. Paralelly, a statistically significant survival decrease was observed, if the concentration of vitamin E in the culture medium exceeded 500 ćg/ml. Received results showed different, in defined concentration range, effects of the vitamin C or vitamin E activity for adriamycin cytotoxicity. These effects were similar for all the examined cells.


    325/2523

    Tytuł oryginału: Synthesis of new N-substituted cyclic imides with expected anxiolytic activity. [P.] 21: Derivatives of 1,4-dibromo-dibenzo[e.h]bicyclo-[2.2.2]octane-2,3-dicarboximide.
    Autorzy: Kossakowski Jerzy, Krawiecka Mariola, Perliński Mirosław
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.37-43, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The preparation is described of a number of new-N-substituted derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide with potential anxiolytic activity.


    326/2523

    Tytuł oryginału: Investigation of interaction of promethazine with cyclodextrins.
    Autorzy: Lutka Anna
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.45-51, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The effect of á-CD and its substituted derivatives (DM-á-CD and HP-á-CD) on the solubility and photostability of promethazine was investigated in solution and in the solid state. The soluble complexes of protonated (pH = 6.8) and basic (pH = 10.8) forms of promethazine with CDs were studied using the spectral method. The influence of pH and CD complexation on photostability of PM in solution was followed. It was found that the photochemical decomposition of promethazine (PM) alone and in the presence of CD procedes according to the first order reaction. It was also established that as well the presence of CD procedes according to the first order reaction. It was also established that as well the presence of CD as the acidic medium of reaction increased the photostability of PM in solution. Formation of solid inclusion complexes of PM with CDs was evaluated using FT IR, 13C NMR and DCS methods. The results obtained indicate that independently of the complexation method in the solid state (kneading or heating), the presence of CD decreases the solubility of PM; the reason may be that phenothiazine ring of PM did not enter into the cavity of á-CD and its derivatives.


    327/2523

    Tytuł oryginału: Flavonoid compounds from Pyrus communis L. flowers.
    Autorzy: Rychlińska Izabela, Gudej Jan
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.53-56, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Five flavonoid glycosides: kaempferol 3-0-á-D-glucopyranoside (IV), isorhamnetin 3-0-á-D-glucopyranoside (V), isorhamnetin 3-0-á-D-(6'-0-ŕ-L-rhamnopyranosyl)-glucopyranoside (VIII), 8-methoxykaempferol 3-0-á-D-(2'-0-ŕ-D-glucopyranosyl)-glucopyranoside (VI), 8-methoxykaempferol 3-0-á-D-(2'-0-ŕ-L-rhamnopyranosyl)-glucopyranoside (VII) and chlorogenic acid (IX) were isolated from the flowers naturally growing Pyrus communis L. They were identified by chemical and spectroscopic methods.


    328/2523

    Tytuł oryginału: Flavonoids in the leaves with stems of some species of the Aquilegia L. genus.
    Autorzy: Bylka Wiesława
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.57-60, tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Methanolic extracts from the leaves with stems of seven species of Aquilegia L. genus (A. hybrida Scott-Eliot, A. olympica BOISS., A. flabellata SIEB et ZUCC., A. alpina L. atrata W.D.J. KOCH, A.vitoleili L., A. caerulea JAMES) were subjected to co-chromatography with the extract and the flavonoids obtained from A. vulgaris L. Moreover, the content of 4'-methoxyapigenin 6-C-glucoside (isocytisoside) was determined spectrophotometrically in these species after chromatographic separation.


    329/2523

    Tytuł oryginału: Optimization of the separation of some Chelidonium maius L. alkaloids by reversed phase high-performance liquid chromatography using cyanopropyl bonded stationary phase.
    Autorzy: Petruczynik Anna, Gadzikowska Maria, Waksmundzka-Hajnos Monika
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.61-64, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The high-performance liquid chromatographic method using two stationary phases: RP-18 and cyanopropyl silica for the analysis of some alkaloids in Chelidonium maius L. extracts is performed. The extract was chromatographed using a mobile phase composed of an organic modiffer (acetonitrile, methanol, tetrahydrofuran or 1,4-dixan), phosphate buffer and sodium octadecylsulfate or di(2-ethyl hexyl) orthophosphoric acid (HDEHP) as ion-pairing reagents. The influence of the different kind of stationary phase and organic modifiers on retention has been compared. In order to improve the selectivity of separation and peak shape, gradient elution was applied.


    330/2523

    Tytuł oryginału: Effect of desogestrel on blood-lipid in relation to its biological activities.
    Autorzy: Saha Achintya, Roy Kunal, De Kakali, Sengupta Chandana
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.65-69, tab., bibliogr. 35 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Desogestrel (DG), a 19-nor progestin, is widely used in replacement therapy as a contraceptive steroidal hormone. Considering the importance of its partition coefficient parameter (log P = 5.68), a significant contributor to its action mechanism, interactions of the drug with blood-lipids, had been investigated using phospholipid binding, fatty acid composition and peroxidation phenomena as the parameters under investigation to explain its pharmacodynamic behavior. From the present investigation, it was observed that lipid loss after incubation of whole blood with DG (80 ng/ml, effective contraceptive concentration in blood) for varying periods of time was accompanied with significant changes in fatty acid composition, which may be ascribed to binding affinity of DG with lipid constituens in blood that may have a role in the mediation of its therapeutic effect. Lipid peroxidation induction potential of DG has been quantitatively measured in the context of its toxicity. The results reveal that DG caused significant extent of lipid peroxidation. Ascorbic acid, an antioxidant, at equvalent human dose of 250 mg could significantly reduce DG-induced lipid peroxidation.


    331/2523

    Tytuł oryginału: Influence of captopril and enalapril on some central effects of ethanol.
    Autorzy: Czarnecka Elżbieta, Pietrzak Bogusława
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.71-75, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The influence of captopril and enalapril on acute toxicity of ethanol, ethanol-induced hypothermia, ethanol sleeping time has been investigated in mice. Moreover, the combined effect of captopril and enalapril on spontaneous locomotor activity in mice has been examined. The captopril (5 and 20 mg/kg) and enalapril (5 and 20 mg/kg) were injected intraperitoneally i.p. The drugs were given as single or repeated doses for 10 days. It has been shown that the captopril and enalapril administered in single doses decreases, but chronic administration increase acute toxicity of ethanol. Captopril and enalapril in single doses enhanced, but chronic administration inhibits hypothermic effect of ethanol. Captopril and enalapril reduces ethanol sleeping time. Captopril and enalapril administered for 10 days and enalapril in a single dose 20 mg/kg decreases ethanol induced hyperactivity.


    332/2523

    Tytuł oryginału: Synthesis and tumoricidal activity evaluation of new morin and quercetin sulfonic derivatives.
    Autorzy: Król Wojciech, Dworniczak Szymon, Pietsz Grażyna, Czuba Zenon P., Kunicka Mariola, Kopacz Maria, Nowak Dorota
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.77-79, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 301,378

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • szczury
  • in vitro

    Streszczenie angielskie: Flavonoids are a group of naturally occuring compounds with interesting medical properties, such as antiinflammatory, antiallergic, antibacterial and antitumor activities. In our experiments we were trying to examine the tumoricidal activity of newely synthesized derivatives of two flavonoids: 3,5,7,2',4' - pentahydroxyflavone (morin) and 3,5,7,3',4' - pentahydroxyflavone (quercetin). The derivatives were: natrium salt of morin-5'-sulfonic acid (NaMSA), natrium salt of quercetin-5'-sulfonic acid (NaQSA), complex of Mg2+ with quercetin-5'-sulfonic acid (QSA), complex of iron (II) with QSA. The antitumor activity of these agents was tested in vitro on two cell lines: L1210 - murine lymphocytic leukaemia and P-815 - murine mastocytoma. Our experiments showed that sulfonic derivatives of these two flavonoids were less potent than the original agents in their cytostatic and cytotoxic activities. However, their solubility in water was grweater than that of the original agents and higher cilture medium concentration of these derivatives was obtained. The results indicate that the ability of flavonoids to act tumoricidally is reciprocally correlated with their lipophilicity.


    333/2523

    Tytuł oryginału: The immunophenotype of patients with recurrent pregnancy loss.
    Autorzy: Darmochwał-Kolarz Dorota, Leszczyńska-Gorzelak Bożena, Roliński Jacek, Oleszczuk Jan
    Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 103 (1) s.53-57, tab., bibliogr. 17 poz.
    Sygnatura GBL: 305,582

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Objective: The aim of the study was to estimate the alterations in the phenotype of lymphocytes of women with unexplained pregnancy failures in comparison with healthy women. Materials and methods: Fourten women with unexplained habitual miscarriages and 18 healthy, fertile women with the history of successful pregnancies were included in the study. The lymphocytes were isolated from peripheral blood and stained with monoclonal antibodies. The expression of selected surface molecules was estimated using the flow cytometric method. Results: We found that the percentage of T CD4+ lymphocytes, CD3-16/56+ cells, and T CD8+11b- cells was significantly higher in patients with recurrent pregnancy loss in comparison with healthy women. The peercentage of B-1 CD19+5+ lymphocytes was also significantly higher in women with unexplained habitual miscarriages in comparison with healthy women. Furthermore, we found higher expression of CD25 molecule on T CD3+ and T CD4+ lymphocytes in the study group, when compared to controls. Moreover, the percentages of B CD19+ and T suppressor CD8+11b+ lymphocytes were lower in women with pregnancy failures in comparison with the control group. The percentage of T CD3+ lymphocytes and T CD8+ cells did not differ in both studied groups. Similarly, the expression of CD25 antigen and HLA-DR molecule on T CD8+ did not differ in the study group, when compared to controls. Concvlusion: Our results can suggest that immunological alterations may be involved in the etiopathogenesis of unexplained recurrent pregnancy loss.


    334/2523

    Tytuł oryginału: Direct antimicrobial properties of substance P.
    Autorzy: Kowalska Katarzyna, Carr Daniel B., Lipkowski Andrzej W.
    Źródło: Life Sci. 2002: 71 (7) s.747-750, il., tab., buibliogr. 14 poz.
    Sygnatura GBL: 304,948

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: The structural similarity between substance P (SP, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Gly-Leu-Met-NH2) and Arg/Pro rich bactericidal peptides suggests a possible direct effect of SP on invasive microbes. We now present evidence that substance P possesses direct antimicrobial activity, highest against S. aureus. A substance P antagonist allso possess such activity but while less potent than substance P agonist S. aureus, is more potent than substance P against C. albicans. Our data also show that the endogenous peptides bradykinin and neurotensin, that also play role in modulation of the host-defense system in situ, have antimicrobial properties but are less potent than substance P.


    335/2523

    Tytuł oryginału: New renin inhibitors with pseudodipeptidic units in P1-P1' and P2'-P3' positions.
    Autorzy: Paruszewski Ryszard, Jaworski Paweł, Winiecka Iwona, Tautt Jadwiga, Dudkiewicz Jadwiga
    Źródło: Chem. Pharm. Bull. (Tokyo) 2002: 50 (6) s.850-853, tab., bibliogr. 21 poz.
    Sygnatura GBL: 304,601

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A series of four new potential renin inhibitors has been synthesized. The structure of the compounds was designed in such a way as to produce agents resistant to enzymatic degradation, metabolically stable, possibly potent and with improved oral absorption. All positions of the 8-13 fragment of the human angiotensinogen were occupied by unnatural units (two unnatural amino acids in position P3 and P2 and two pseudodipeptides in positions P1-P1, and P2-P3,). Both N- and C-terminal functions of the inhibitors were blocked with tert-Boc and ethyl ester groups. Their hydrophobicity evaluated as a log P value, calculated by a computer method, was 6.57 and 6.08 respectively. All peptides were obtained by the carbodiimide method in solution and purified by chromatography on the SiO2 column. Their resistance to enzymatic degradation was assayed by determination of stability against chymotrypsin activity. The potency was measured in vitro by a spectrofluorimetric method (assay of Leu-Val-Tyr-Ser released from the N-acetyltreadecapeptide substrate by renin in the presence of the inhibitor). All inhibitors were stable to chymotrypsin. Their IC50 (M/I) values were: 9.6 x 10**-4 (12), 1.6 x 10**-5 (17), 1.0 X 10**-5 (22) and 1.0 x 10**-5 (23) respectively.


    336/2523

    Tytuł oryginału: Myocardial ischemia possibly mediated by cysteinyl leukotrienes.
    Autorzy: Szczeklik Andrew, Niżankowska Ewa, Mastalerz Lucyna, Bochenek Grażyna
    Źródło: J. Allergy Clin. Immunol. 2002: 109 (3) s.572-573, tab., bibliogr. 8 poz.
    Sygnatura GBL: 301,408

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • list i notatka
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska


    337/2523

    Tytuł oryginału: PRESTO (a mammoth trial that could have been prevented), HPS and REMATCH.
    Autorzy: Doehner Wolfram, Ponikowski Piotr, Anker Stefan D.
    Źródło: Int. J. Cardiol. 2002: 83 (2) s.99-102, bibliogr. 17 poz. - 74 Doroczne Spotkanie Towarzystwa Chorób Serca Anaheim 11. 2001
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    338/2523

    Tytuł oryginału: Myocardial ischemia and autonomic activity in dippers and non-dippers with coronary artery disease: assessment of normotensive and hypertensive patients.
    Autorzy: Kurpesa Małgorzata, Trzos Ewa, Drożdż Jarosław, Bednarkiewicz Zbigniew, Krzemińska-Pakuła Maria
    Źródło: Int. J. Cardiol. 2002: 83 (2) s.133-142, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 305,693

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: The aim of this study was to assess the relations between the circadian variations of blood pressure (BP) and the pattern of ischemia and autonomic activity in normotensive and hypertensive patients with coronary artery disease (CAD). Patients and methods: On the basis of the results of ambulatory BP monitoring, 115 patients with stable CAD were divided into Group 1 (with arterial hypertension) and Group 2 (normotensives). Groups were subdivided into dippers and non-dippers. Holter monitoring was performed to assess the occurrence and circadian pattern of ischemic episodes. Time domain and frequency domain HRV analyses were performed to evaluate the autonomic activity. Results: The total number of ischemic episodes was similar in dippers and non-dippers. Non-dippers had a greater number of silent episodes and a different circadian pattern of ischemia with more night episodes. Among the time-domain HRV parametres, only SDNN was similar in dippers and non-dippers. Non-dippers had lower pNN50 and rMSSD - the parameters expressing parasympathetic activity. Differences between diurnal and nocturnal results of spectral HRV analysis were observed in dipper patients only. They presented an elevation of HF power and a decline of LF power at night. All differences between dippers and non-dippers were of similar significance in both hypertensives and normotensives. Conclusions: A lack of a nocturnal fall in BP is present in normotensive and hypertensive patients with CAD. Non-dippers with CAD had silent and nightime ischemia more often. They also had an abnormal pattern of autonomic activity with higher sympathetic and lower parasympathetic modulation.


    339/2523

    Tytuł oryginału: Serum levels of selected adhesion molecules in patients with coronary artery disease.
    Autorzy: Mizia-Stec Katarzyna, Zahorska-Markiewicz Barbara, Mandecki Tadeusz, Janowska Joanna, Szulc Andrzej, Jastrzębska-Maj Ewa
    Źródło: Int. J. Cardiol. 2002: 83 (2) s.143-150, tab., bibliogr. 32 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Adhesion molecules have been suggested as mediators of atherosclerotic inflammatory process. They may contribute to the pathogenesis of stable and unstable angina. Methods: The study group consisted of 59 patients with coronary artery disease: 27 patients with stable exertional angina (group A), 32 patients with unstable angina (group B). 20 healthy persons acted as controls (group C). Serum levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1), Vascular Cell Adhesion Molecule 1 (sVCAM-1), sE-selectin, sP-selectin were measured both before and after the treadmill ECG stress test in groups A and C. In group B the measurements were carried out at 6, 24, and 48 hours following an episode of chest pain. Results: There were no differences between the baseline serum levels of adhesion molecules as determined in groups A and C. In patients with stable angina, the post-exercise concentrations of sE-selectin were significantly higher (68.8 ń 29 ng/ml) in comparison to both baseline- (38.7 ń 15 ng/ml), and group C-values (pre-exercise: 35.1 ń 16; post-exercise: 49.9 ń 15 ng/ml). In unstable patients, serum sP-selectin (190.1 ń 99 ng/ml) and sVCAM-1 levels (1359 ń 299 ng/ml) were higher when compared to those found in groups A (142.3 ń 24; 962 ń352 ng/ml, respectively) and C (136.4 ń 33; 851 ń 168 ng/ml, respectively). Conclusions: Serum levels of soluble adhesion molecules in patients with stable angina are comparable to those of healthy persons. Stress test-induced increase of sE-selectin concentration may reflect endothelial response to exercise. Unstable angina is characterized by significant elevation of sP-selectin and sVCAM-1 serum levels which seems to be related to enhanced platelets and leukocytes activation.


    340/2523

    Tytuł oryginału: Atrial natriuretic peptide level after cardioversion of chronic atrial fibrillation.
    Autorzy: Wozakowska-Kapłon Beata, Opolski Grzegorz
    Źródło: Int. J. Cardiol. 2002: 83 (2) s.159-165, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Heart endocrine studies concerning patients with chronic atrial fibrillation (AF) have become increasingly important. Atrial natriuretic peptide (ANP) is released from atrial myocytes. The increased level of ANP in patients with AF is probably caused by the hemodynamic effect of the arrhythmia. The aim of this study was to explore plasma ANP levels in patients with chronic AF and to describe plasma ANP concentration changes following sinus rhythm (SR) restoration. The study group was comprised of 42 patients, aged between 43 and 76 years with chronic ASF (more than 1 month) and a relatively controlled ventricular response (85.8 ń 11.3 beats/min). Plasma ANP levels were measured before and 24 h after AF cardioversion. The control group comprised of 11 subjects. All had normal SR without history of AF and were compatible in age, sex and concomitant diseases with the examined group. ANP level values were expressed as mean ń standard deviation. The mean plasma ANP level in the AF group was significantly higher than in the control group (59.5 ń 16.6 vs. 34.3 ń 10.2 pg/ml, P 0,001). Electrical or pharmacological cardioversion was performed in 42 patients. SR was succesfully restored in 35 patients. Plasma ANP concentrations decreased significantly from baseline values (from 59.4 ń 16.6 to 31.4 ń 15.0 pg/ml, P 0.001) 24 h after cardioversion in the successful group, while they remained unchanged (60.2 ń 10.7 to 59.4 ń 10.4 pg/ml, NS) in patients with an unsuccessful cardioversion. Conclusion: The mean concentration of ANP in patients with chronic AF was nearly two-times higher than in the control group with sinus rhythm. Conversion to SR was associated with a significant decrease and normalization in plasma ANP concentrations.


    341/2523

    Tytuł oryginału: Inhibitory effect of acetylsalicylic acid on metalloproteinase activity in human lung adenocarcinoma at different stages of differentiation.
    Autorzy: Karna Ewa, Pałka Jerzy A.
    Źródło: Eur. J. Pharmacol. 2002: 443 (1/3) s.1-6, il., tab., bibliogr. s. 5-6
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The mechanism underlying the anticancer effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is not clear. We adressed the question whether the alterations in collagen content in lung adenocarcinomas reported in previous studies result from dysregulation of gelationylytic activity and whether the activity is altered by acetylsalicylic acid in vitro. Human lung adenocarcinomas were divided into three groups: well-differentiated (G1), moderately differentiated (G2) and poorly differentiated (G3) tumors. Each group was compared with normal lung tissue with respect to tissue collagean and collagen degradation product content (hydroxyproline assay), gelatinolytic activity (zymography) and the expression of matrix metalloproteinases, MMP-2 and MMP-9 (Western immunoblot). Moreover, in the studied tissues, the effect of acetylsalicylic acaid on gelatinolytic activity was measured. The lung adenocarcinoma G1 had a similar collagen content as normal lung tissue but increased amounts of collagen degradation products and free hydroxyproline. These phenomena were accompanied by a marked increase in gelatinolytic activity (NMP-2 and MMP-9) in the G1 tumor. In adenocarcinoma G2, the free hydroxyproline content and gelatinolytic activity were increased, while the collagen and collagen degradation product contents were not markedly altered, compared to control. In contrast, adenocarcinoma G3 had an increased tissue collagen content (by about 60 p.c.), decreased percentage of collagen degradation products and similar gelatinolytic activity, compared to normal lung. Acetylsalicylic acid...


    342/2523

    Tytuł oryginału: Imipramine but not 5-HT1A receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT1A and 5-HT4 receptors.
    Autorzy: Zahorodna Agnieszka, Tokarski Krzysztof, Bijak Maria
    Źródło: Eur. J. Pharmacol. 2002: 443 (1/3) s.51-57, il., bibliogr. s. 56-57
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: It has been reported that the treatment with a tricyclic antidepressant imipramine induces an increase in the sensitivity of 5-HT1A receptors and a decrease in the sensitivity of 5-HT4 receptors in the rat hippocampus. 5-HT1A receptor agonists and neuroleptics also affect 5-HT1A receptors in different brain areas; therefore, it was of interest to compare their effects on hippocampal 5-HT receptors with the influence of the well-established antidepressant imipramine. We studied the effects of repeated treatment with imipramine, the 5-HT1A receptor agonists 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone, and the neuroleptics haloperidol and clozapine on the sensitivity of rat hippocampal CA1 neurons to 5-HT1A - and 5-HT4 receptor activation. Imipramine was administered for 21 days (10 mg/kg p.o., twice daily), 8-OH-DPAT for 7 days (1 mg/kg s.c., twice daily) and buspirone for 21 days (5 mg/kg s.c., twice daily). The rats received haloperidol (1 mg/kg) and clozapine (30 mg/kg) for 6 weeks in drinking water. Hippocampal slices were prepared 2 days after the last treatment with imipramien, 8-OH-DPAT or buspirone, and 5 days after the last treatment with the neuroleptics. Using an extracelllar in vitro recording, we studied changes in the amplitude of stimulation-evoked population spikes, induced by 5-HT, 8-OH-DPAT and the 5-HT4 receptor agonist zacopride. Activation of 5-HT1A receptors decreased, while activation of 5-HT4 receptors increased the amplitude of population spikes. Imipramine significatly enhanced the inhibitory effects of 5-HT and 8-OH-DPAT, and attenuated...


    343/2523

    Tytuł oryginału: Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism.
    Autorzy: Kowalska Irina, Strączkowski Marek, Szelachowska Małgorzata, Kinalska Ida, Prokop Jolanta, Bachórzewska-Gajewska Hanna, Stępień Agnieszka
    Źródło: Metabolism 2002: 51 (6) s.733-736, tab., bibliogr. 22 poz.
    Sygnatura GBL: 303,583

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie angielskie: It is hypothesized that adhesion molecules could be an early predictor of coronary artery diseases. Therefore we investigated the relationship between the concentrations of soluble forms of adhesion molecules and disturbances of glucose metabololism in 78 men referred for coronary angiography but with no previous history of diabetes. The group consisted of 78 men (mean age, 47.6 ń 7.0 years; mean body mass index [BMI], 28.4 ń 3.24 with the symptoms of angina pectoris and positive exercise test. All subjects were given a standard oral glucose tolerance test (OGTT) with glucose and insulin estimations. Fasting plasma concentrations of the soluble (s) forms of E-selectin, intercelular adhesion cell molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and HbA1c were also measured. According to the OGTT, 10.2 p.c. of the patients (n = 8) fulfilled the criteria for type 2 diabetes mellitus and 44.9 p.c. (n = 35) for impaired glucose tolerance (IGT). The highest concentrations of sE-selectin were observed in patients with type 2 diabetes mellitus and were significantly higher in comparison to the group with normal glucose tolerance and IGT. The concentration of sVCAM-1 increased with the progression of disturbances of glucose metabolism and remained the highest in type 2 diabetic patients. sICAM-1 concentration was not significantly different. sE-selectin concentration correlated significantly with fasting glucose (r = 0.23, P = .041), postload glucose (r = 0.39, P = .001), and postload...


    344/2523

    Tytuł oryginału: Increased rate of cholesterologenesis - a possible cause of hypercholesterolemia in experimental chronic renal failure in rats.
    Autorzy: Szołkiewicz M[arek], Sucajtys E., Chmielewski M., Wołyniec W., Rutkowski P., Bogusławski W., Świerczyński J., Rutkowski B[olesław]
    Źródło: Horm. Metab. Res. 2002: 34 (5) s.234-237, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 312,226

    Hasła klasyfikacyjne GBL:
  • genetyka
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Hipercholesterolemia plays an important role in the lipid abnormalities in chronic renal failure (CRF). It is thourght to contribute to both a progression of renal failure and atherosclerosis. Despite intensive research, the etiopathogenesis of hypercholesterolemia in CRF patients is still obscure. The present sudy was designed to evaluate the possible role of cholsterol overproduction in the development of hypercholesterolemia associated with experimental CRF. We found that plasma total cholesterol and cholesterol distributed in VLDL, LDL and HDL concentrations were significantly enhanced in CRF rats. Simultaneously, the rate of liver cholesterol biosynthesis in vivo (measured by determining the incorporation of tritium from tritiated water intraperiotoneally injected into cholesterol), liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and liver HMG-CoA reductase mRNA presence were elevated. Significant increases in activity of liver malic enzyme, glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase NADPH-producing enzyme (required for cholesterol synthesis) have also been observed in CRF rats. In conclusion, the increased rate of liver cholesterol biosynthesis due to increase of HMG-CoA reductase and NADPH-producing enzyme gene expression could be one of the possible causes of hypercholesterolemia in CRF animals.


    345/2523

    Tytuł oryginału: Knockdown of spinal opioid receptors by antisense targeting á-arrestin reduces morphine tolerance and allodynia in rat.
    Autorzy: Przewłocka Barbara, Sieja Agnieszka, Starowicz Katarzyna, Maj Marcin, Bilecki Wiktor, Przewłocki Ryszard
    Źródło: Neurosci. Lett. 2002: 325 (2) s.107-110, il., bibliogr. 13 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The development of morphine tolerance and sciatic nerve injury-induced allodynia after functional knockdown of spinal opioid receptors using antisense oligonucleotides targetin á-arrestin was investigated. Ineffectiveness of morphine in neuropathic pain suggests an implication of the same mechanism in these two processes. The development of morphine tolerance (10 ćg intrathecally (i.th.), every 12 h) was significantly inhibited in rats, which received i.th. á-arrestin antisenses (2 nM). Acute and chronic (6 days) i.th. administration of antisenses antagonized the allodynia in the rat model of neuropathic pain. Our results demonstrated that i.th. administration of á-arrestin antisenses delayed development of tolerance to morphine and nerve injury-induced cold allodynia, which suggest that both of the investigated phenomena may be mediated by a similar mechanism, e.g. receptor desensitization. Moreover, the antisense oligonucleotides targeting á-arrestin may constitute a new approach to the therapy of neuropathic pain.


    346/2523

    Tytuł oryginału: Applications of derivative UV spectrophotometry for the determinations of cetirizine dihydrochloride in pharmaceutical preparations.
    Autorzy: Drozd Joanna, Hopkała Hanna, Misztal Genowefa, Paw Beata
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.3-7, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A method for the determination of cetirizine dihydrochloride in pharmaceuticals by first-, second-, third- and fourth- order derivative spectrophotometry is described, using "peak" (P-P), and "peak - zero" (P-0) measurements. The calibration curves are linear within the concentration range of 7.5 - 22.5 ćg ml-1 for cetrizine dihydrochloride. The procedure is simple, rapid and the results are reliable.


    347/2523

    Tytuł oryginału: Determination of active substances in antiallergic and antiphlogistic multicomponent preparations by high performance liquid chromatography (HPLC).
    Autorzy: Białecka Wanda, Kulik Anna, Kaniewska Teresa
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.9-14, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of the present study was elaboration of an HPLC method enabling the identification and deterrmination of the content of selected compounds occurring in multicomponent preparations applied in allergic and non-allergic diseases of upper respiratory tracts. These compounds include: buzepide methyl iodide, clocinizine dihydrochloride, phenylpropanolamine hydrochloride, pseudophedrine sulfate and dexbrompheniramine maleate. The elaborated HPLC method shows that a good separation of the mentioned compounds is feasible. The regression analysis has demonstrated lineary of the method in concentration range suitable for the intended experiments. The determination of the compounds in pharmaceutical preparation and the statistical evaluation of the results indicate that both selectivity and precision of the method are good.


    348/2523

    Tytuł oryginału: Determination of the active ingredient loperamide hydrochloride in pharmaceutical caplets by high performance thin layer chromatography with ultraviolet absorption densitometry of fluorescence quenched zones.
    Autorzy: Ruddy Daniel A., Sherma Joseph
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.15-18, tab., bibliogr. 11 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A gantitative method using silica gel HPTLC plates with fluorescent indicator, automated sample application, and automated UV absorption densitometry of the fluorescence quenching zones was developed and validated for determination of loperamide hydrochloride in anti-diarrheal medications. Samples of three brands of caplets assayed within 96.0 - 105 p.c. of the 2 mg label value. Repeatability was 3.3 p.c., 1.6 p.c. and 2.8 p.c. (RSD) for replicate analyses (n = 6) of three tablets. The errors of a blank-spike and standard analyses performed to evaluate accuracy were 2.00 p.c. and 2.02 p.c., respectively. The method is suitable application in a drug manufacturing quality control or regulatory analysis laboratory.


    349/2523

    Tytuł oryginału: The stability of oxymetazoline hydrochloride in aqueous solution.
    Autorzy: Stanisz Beata
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.19-23, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The kinetics of the hydrolysis reaction of oxymetazoline hydrochloride in aqueous solution at three temperaturtes (343 K, 353 K, 363 K), over the pH-range 0.5 - 12.5 and ionic strenght 0.5 has been investgated. The changes of concentration of oxymetazoline hydrochloride were followed by the HPLC method with UV detection. In the pH range from 0.45 to 12.50, the hydrolysis of oxymetazoline consist of hydrolysis of oxymetazoline molecules catalyzed by hydrogen ions, spontaneous hydrolysis of the dissociated and undissociated oxymetazoline molecules. A minimal rate of the hydrolysis oxymetazoline was observed to occur in the pH range from 2.0 to 5.0. Thermodynamic parameters of the reaction: energy, entropy and enthalpy of activation and the frequency factor for the specific rate constans were determined.


    350/2523

    Tytuł oryginału: Kinetics of talampicillin decomposition in solutions.
    Autorzy: Pawełczyk Ewaryst, Płotkowiak Zyta, Helska Maria
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.25-29, tab., bibliogr. 9 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Talampicillin stability in aqueous solutions was studied in a broad range of pH values using as medium solutions of hydrochloric acid (pH 0.4 - 1.8), phosphate buffers (pH 2.05 - 3.13 and 6.03 - 8.04), acetate buffer (pH 3.87-5.28) and borate buffer (pH 8.90 - 9.10) as well as sodium hydroxide solution (pH 11.48). For the determination of talampicilin concentration changes in kinetic studies, two methods were used: iodometric and spectrophotometric in UV(lambdamax = 254.5 nm). The catalytic velocity constans (kh+, kx, ko) were established, the log k-pH profile (35řC) was found, thermodynamic parameters were calculated of the hydrolisis reaction of the á-lactam bond (kH+: EA=67.9 kJ mol**-1, Delta S"= -92.4 JK**-1 mol-1, Delta G"=92.6 kJ mol**-1; kx:EA = 31.8 kJ mol**-1, Delta S" = 347.1 JK**-1 mol**-1, Delta G" =131.1 kJ mol**-1...


    351/2523

    Tytuł oryginału: A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody.
    Autorzy: Wojewódzka Maria, Buraczewska Iwona, Kruszewski Marcin
    Źródło: Mutat. Res 2002: 518 (1) s.9-20, il., bibliogr. 43 poz.
    Sygnatura GBL: 304,952

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Comet assay under neutral conditions allows the detection of DNA double-strand breaks (DSB), considered to be the biologically relevant radiation-induced lesion. In this report, we describe modifications of the neutral comet method, which simplify and facilitate its use for estimation of DNA DSB in X-irradiation mammalian cells in centure. The analysis carried out according to this protocol takes less time than those most often applied. Also, the use of lysis at 50ř C is avoided; this is important in view of the presence of heat-labile sites in the chromatin of irradiated cells, recently reported by Rydberg [Radiation-induced heat-labile sites that convert into DNA double-strtand breaks, Radsaiation Research 153 (2000) 805-812]. The comets have well-defined, sharp limits, suitable for image analysis. The chromatin of the hydrogen peroxide-treated or UV-C-irradiated cell remains condensed similarly to that of the control cells. We checked the neutral comets for the presence of single-stranded DNA by means of a specific antibody. The results point to a satisfactory sensitivity of the modified neutral comet assay and its specificity for DSB. The minimum detection level of the modified neutral comet assay is about 5 Gy.


    352/2523

    Tytuł oryginału: Countrywide spread of CTX-M-3 extended-spectrum á-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland.
    Autorzy: Baraniak Anna, Fiett Janusz, Sulikowska Agnieszka, Hryniewicz Waleria, Gniadkowski Marek
    Źródło: Antimicrob. Agents Chemother. 2002: 46 (1) s.151-159, tab., bibliogr. 42 poz.
    Sygnatura GBL: 305,849

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Eighty-four clinical isolates of the family Enterobacteriaceae from 1998 to 2000 in 15 hospitals in 10 polish cites, were analyzed. All the isolates produced á-lactamases with pIs of 8.4 and 5.4, and the pI 8.4 enzymes were demonstrated to hydrolyze cefotaxime but not ceftazidime in the in vitro bioassay. PCR analysis and DNA sequencing have revealed that in all cases the pI 8.4 á-lactamase was probably the CTX-M-3 extended-spectrum á-lactamase (ESBL) variant, which was originally identified in 1996 in Praski Hospital in Warsaw. In the majority of isolates, blaCTX-M-3 genes resided large conjugative plasmids with similar fingerprints, which, in the contex of the high degree of diversity of the randomly amplified polymorphic DNA types of the isolates, suggest that horizontal transfer of plasmids was likely the main mechanism of CTX-M-3 spread. The dissemination of plasmids was probably preceded by the center-to-center transmission of several strains, as indicated by the identification by pulsed-field gel electrophoresis of closely related or possibly related Klebsiella pneumoniae, Eschrichia coli, and Citrobacter freundii isolates in five different hospitals. CTX-M-3-producing organisms revealed a very high degree of diversity in á-lactam resistance levels and patterns. This was attributed to several factors, such as the production of other á-lactamases including additional ESBLs, possible quantitative variations in CTX-M-3 expression, segregation of AmpC derepressed mutants, and permeability alterations.


    353/2523

    Tytuł oryginału: A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICAM-1) in children with asthma.
    Autorzy: Stelmach Iwona, Jerzyńska Joanna, Kuna Piotr
    Źródło: J. Allergy Clin. Immunol. 2002: 109 (2) s.257-263, il., tab., bibliogr. 43 poz.
    Sygnatura GBL: 301,408

    Hasła klasyfikacyjne GBL:
  • pediatria
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Background: Anti-inflammatory properties of leukotriene modifiers and their on bronchial hyperresponsiveness have npt been studied in children with asthma. Objective: The primary objective of this study was to determine the changes in serum levels of inflammatory mediators, clinical efficacy, and bronchial hyperresponsiveness after treatment with montelukast. Methods: In this double-blind, randomized, placebo-controlled trial, 39 children with mild-to-moderate atopic asthma were randomly allocated to receive montelukast or placebo or 6 weeks. Main outcome measures were changes in serum concentrations of soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICAM-1); peripheral blood eosinophil count; and eosinophilic cationic protein (ECP). Asthma severity score, FEV1, and bronchial hyperreactivity (BHR) for histamine were secondary end points. Results: Compared to placebo, serum concentrations of IL-4 sICAM-1, and ECP and eosinophil blood counts significantly decreased after 6 weeks of treatment with montelukast. Montelukast significantly improved asthma control and FEV1. Montelukast resulted in within-group significant decrease in levels of serum sIL-2R (611 vs 483 pg/mL), IL-4 (0.123 vs 0.102 pg/mL), sICAM-1 (280 vs 244 ng/mL), and ECP (74 vs 59 ćg/mL) and in eosinophil blood counts (349 vs 310 cells/mm3). Mean FEV1 value changed from 85 p.c. of predicted to 95 p.c. (P .001) and for histamine (PC20H) from 2.8 mg/L to 3.8 mg/mL (P .001) after treatment with montelukast...


    354/2523

    Tytuł oryginału: Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism.
    Autorzy: Feleszko Wojciech, Młynarczuk Izabela, Olszewska Dominika, Jalili Ahmad, Grzela Tomasz, Lasek Witold, Hoser Grażyna, Korczak-Kowalska Grażyna, Jakóbisiak Marek
    Źródło: Int. J. Cancer 2002: 100 (1) s.111-118, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 305,029

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Lovastatin, a drug successfully used in the clinic to prevent and to treat coronary heart disease, has recently been reported to decrease the incidence of melanoma in lovastatintreated patients. Lovastatin has also been proved to potentiate antitumor effects of both cisplatin and TNF-ŕ in murine melanoma models. Recently, an augmented therapeutic effect of lovastatin and doxorubicin has been reported in 3 tumor models in mice. In our preliminary study lovastatin caused retardation of melanoma growth in mice treated with doxorubicin (Feleszko et al. J. Nati Cancer Inst 1998;90:247-8). In the present report, we supplement our preliminary observations and demonstrate in 2 murine and 2 human melanoma cell lines that lovastatin effectively potentiates the cytostatic/cytotoxic activity of doxorubicin in vitro via an augmentation of apoptosis (estimated with PARP-cleavage assay, annexin V assay and TUNEL). The combined antiproliferative activity of lovastatin and doxorubicin was evaluated using the combination index (CI) method of Chou and Talalay, revealing synergistic interactions in melanoma cells exposed to lovastatin and doxorubicin. In BI6FI0 murine melanoma model in vivo, we have demonstrate significantly increased sensitivity to the combined treatment with both lovastatin (5 mg/kg for 14 days) and doxorubicin (4 x I mg/kg) as compared with either agent acting alone. Lovastatin treatment resulted also in significant reduction of the number of experimental metastasis in doxorubicin-treated mice The results of our studies suggest that lovastatin may enhance the effectiveness of chemotherapeutic agents in the treatment of malignant melanomas.


    355/2523

    Tytuł oryginału: Adsorption characteristics of human plasma fibronectin in relationship to cell adhesion.
    Autorzy: Kowalczyńska Hanna M., Nowak-Wyrzykowska Małgorzata, Dobkowski Jacek, Kołos Robert, Kamiński Jarosław, Makowska-Cynka Alicja, Marciniak Ewa
    Źródło: J. Biomed. Mater. Res. 2002: 61 (2) s.260-269, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 305,818

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Adsorption of human plasma fibronectin (FN) on nonsulfonated and sulfonated polymer surfaces was studied, by using a polyclonal antiserum to FN and the ELISA method. ELISA signal was recorded as a function of FN concentration in solutions. The concentration dependence of FN binding shows the saturation effect in the range 5-10 ćg/mL. ELISA data are discussed in the terms of a self-assembled monolayer and different conformations of the FN molecule. The early adhesion of L1210 cells to polymer surfaces after prior adsorption of FN on these surfaces was studied under static conditions. In the case of FN adsorbed on sulfonated surfaces, the relative number of adhering cells increased with the increase of the interfacial surface tension (i.e., the cell adhesion depends on the surface density of sulfonic groups). However, in the case of FN adsorbed on nonsulfonated surfaces, the relative number of adhering cells was low and independent on the interfacial surface tension. The ŕ5á1-integrin blocking by a monoclonal antibody resulted on sulfonated polymer surfaces. This indicates that cell adhesion to FN adsorbed on these surfaces is mostly mediated by the ŕ5á1-integrin. In contrast, in the case of FN adsorbed on nonsulfonated surfaces the cell adhesion was not inhibited by the ŕ5á1-integrin blocking.


    356/2523

    Tytuł oryginału: Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam.
    Autorzy: Maciejak Piotr, Krząścik Paweł, Członkowska Agnieszka I., Szyndler Janusz, Bidziński Andrzej, Walkowiak Jerzy, Kostowski Wojciech, Plaznik Adam
    Źródło: Pharmacol. Biochem. Behav. 2002: 72 (4) s.987-991, il., tab., bibliogr. [11] poz.
    Sygnatura GBL: 312,498

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The effects of allopregnanolone and midazolam, given intracerebroventricularly, on the behavioral and biochemical effects of picrotoxin, were examined in a model of neurotoxin-induced seizures, in mice. After acute injections, midazolam (ED50 = 39.8 nmol) and allopregnanolone (ED50 = 11.0 nmol) produced similar and dose-dependent protection against picrotoxin-induced seizures. Picrotoxin given intraperitoneally at the ED85 dose decreased significantly the concentration of serotonin (5-HT), dopamine (DA), homovanilic acid (HVA) and 3,4-dihydroxyindolacetic acid (DOPAC), in the mouse striatum and the frontal cortex, in the period of time immediately preceding the onset of seizures. A single injection of allopregnanolone more potently, in comparison to midazolam, antagonized the biochemical action of picrotoxin, abolishing its effects on DA, HVA and 5-HT concentration, in the mouse striatum and the frontal cortex. These results for the first time provide a direct argument for an involvement of central dopaminergic and serotonergic systems in the seizure development. The present data add also to the accumulating evidence suggesting a favorable pharmacological profile for some neurosteroids currently considered to have a future role in the management of epilepsy.


    357/2523

    Tytuł oryginału: The influence of luteinizing hormone-releasing hormone analog on serum leptin and body composition in women with solitary uterine myoma.
    Autorzy: Nowicki Michał, Adamkiewicz Grażyna, Bryc Władysław, Kokot Franciszek
    Źródło: Am. J. Obstet. Gynecol. 2002: 186 (3) s.340-344, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 300,265

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Objective: The purpose of this study was to examine the influence of luteinizing hormone-releasing hormone analog goserelin on serum leptin and body composition in women with solitary uterine myoma. Study design: Fifteen women who were regularly menstruating and not obese were included. In all subjects, serum concentrations of leptin, insulin, testosterone, progesterone, and estradiol and body mass index and waist-to-hip ratio were measured before and after 4, 8, and 12 weeks of treatment with goserelin (3.6 mg every 4 weeks). Fat mass and lean body mass were measured by dual energy radiographic densitometry at baseline and after 12 weeks of therapy. Data were analyzed by multiple way analysis of variance and both simple and multiple regression. Results: The treatment caused a significant regression of myoma. Body weight, fat, ane lean mass were unchanged. No changes in plasma leptin (even after correction for fat mass) were noted during the treatment. Plasma estradiol decreased below castrate levels. Plasma progesterone decreased significantly, and testosterone tended to decline during the study. At baseline a highly significant positive correlation was found between serum leptin and fat mass. In a multiple regression analysis, neither the change in fat mass nor any of the hormonal parameters explained the significant portion of variance of plasma leptin during the treatment. Conclusion: Pharmacologic gonadectomy does not influence plasma leptin concentrations in women if body fat mass is unchanged.


    358/2523

    Tytuł oryginału: Journal of Pharmacy and Pharmacology
    Tytuł polski: Pharmacological properties and SAR of new 1,4-disubstituted piperazine derivatives with hypnotic-sedative activity.
    Autorzy: Chilmonczyk Zdzisław, Mazgajska Maria, Iskra-Jopa Joanna, Chojnacka-Wójcik Ewa, Tatarczyńska Ewa, Kłodzińska Aleksandra, Nowak Jerzy Z.
    Źródło: J. Pharm. Pharmacol. 2002: 54 (5) s.689-698, il., tab., bibliogr. s. 696-698
    Sygnatura GBL: 300,961

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Preparation, pharmacological properties and structure-activity relationships of new pyrimidylpiperazine derivatives, exhibiting sedative and hypnotic activity in mice, are reported. The hypnotic activity of the compounds was comparable with that of zopiclone (the known hypnotic-sedative agent), their interaction with ethanol, however, being much lower. The obtained results suggested that zopiclone and pyrimidylpiperazines 2, 4 and 5 exerted their pharmacological activity through a different mechanism - zopiclone through the interaction with benzodiazepine receptors and compounds 2, 4 and 5 through an unidentified molecular target. The pharmacological properties of compound 3 could be the result of a mixed mechanism of action, combining the properties of zopiclone and those of compounds 2, 4 and 5. A common feature of zopiclone and compounds 2 and 3 was that, after their systemic administration, independently of mechanism of action, together with the hypnotic effect a reduction of the 5-HT turnover in the mouse brain was observed. Minimum structural requirements for the hypnotic activity were formulated. Structural considerations have shown that removing the ŕ-carbonyl group did not influence the drug's ability to inhibit the locomotor activity. However, it did influence its ability to disturb motor coordination or abolish the righting reflex within non-lethal doses.


    359/2523

    Tytuł oryginału: Is diminished pubocervical fascia collagen content a risk factor for failure of surgical management of genuine stress urinary incontinence in women?
    Autorzy: Skorupski Paweł, Rechberger Tomasz, Postawski Krzysztof, Woessner jr J. Frederick, Jakowicki Jerzy A.
    Źródło: Eur. J. Obstet. Gynecol. Reprod. Biol. 2002: 102 (2) s.195-198, tab., bibliogr. 19 poz.
    Sygnatura GBL: 305,582

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Objective: The assessment of relationship between pubocervical collagen content and clinical results of surgical treatment of genuine stress urinary incontinence (GSUI) in women. Methods: Twenty-four women treated for genuine stress urinary inontinence were included into the study. All women underwent the same surgical procedure. The samples of pubocervical fasia were taken at the time of surgery. The contents of acid soluble, pepsin soluble, insoluble fraction of collagen, total collagen and collagen crosslinks were measured. The study of pubocervical fascia collagen metabolism included also estimation of collagen activity. At follow-up done 5 years following surgery, 20 patients reported symptoms of GSUI (study group). Four women were still without symptoms of urine leakage (control group). The biochemical parameters of pubocervical fascia did not show, statistically significant differences between cimpared groups. Conclusions: The pubocervical fascia collagen metabolism does not have impact on the results of anti-incontinence surgery.


    360/2523

    Tytuł oryginału: Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population.
    Autorzy: Malecki Maciej T., Moczulski Dariusz K., Klupa Tomasz, Wanic Krzysztof, Cyganek Katarzyna, Frey Jakub, Sieradzki Jacek
    Źródło: Eur. J. Endocrinol. 2002: 146 (5) s.695-699, tab., bibliogr. 19 poz.
    Sygnatura GBL: 301,344

    Hasła klasyfikacyjne GBL:
  • genetyka
  • endokrynologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: The polymorphisms of two genes have recently been associated with complex forms of type 2 diabetes mellitus (T2DM): calpain 10 and peroxisome proliferator-actvated receptor-ç (PPARç). Calpain 10 is a member of a large family of intracellular protease. It was shown in Mexican-Americans and other populations that variants of three single nucleotide polymorphisms (SNPs), -43, -19, and -63, of this ubiquitously expressed protein influence susceptibility to T2DM. However, substantial differences were shown between ethnic groups in at risk alleles and haplotypes as well as in their attributable risk. Thus, it is important to determine the role of calpain 10 in various populations. Aim: To examine the role of calpain 10 SNPs -43, -19, and -63 in genetic susceptibility to T2DM in a Polish population. Methods: Overall, 377 individuals were examined: 229 T2DM patients and 148 control individuals. The groups were genotyped for calpain 10 SNP-43, SNP-19, and SNP-63. SNP-19 was examined by electrophoresis of the PCR product on agarose gel by size, while the restriction fragment length polymorphism (RFLP) method was used for the two other markers. Difference in allele, genotype, haplotype, and haplotype combination distribution between the groups were examined by Xý test. Results: Distributions of alleles, genotypes, and haplotypes at three loci defined by examined SNPs were not significantly different between the groups. However, the homozygote combination of 121 haplotype was more prevalent in the T2DM group than in the controls (17.9 p.c. vs 10.1 p.c., P = 0.039)...


    361/2523

    Tytuł oryginału: Prognostic value of low-dose dobutamine echocardiography in patients with idiopathic dilated cardiomyopathy.
    Autorzy: Drożdż Jarosław, Krzemińska-Pakuła Maria, Plewka Michał, Ciesielczyk Michał, Kasprzak Jarosław D.
    Źródło: Chest 2002: 121 (4) s.1216-1222, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 300,494

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Study objectives: Dobutamine echocardiography is widely used for the evaluation of myocardial contractile reserve. The purpose of the study was to determine the prognostic value of low-dose dobutamine echocardiography in patients with idiopathic dilated cardiomyopathy (IDCM). Patients: The study group consisted of 77 consecutive patients with recently diagnosed IDCM (mean [ń SD] age, 49 ń 9 years; men, 82 p.c.) and left ventricular (LV) ejection fractions of 40 p.c. Interventions: Two-dimensional and Doppler echocardiographic variables were measured before and after the infusion of dobutamine at the rate of 10 ćg/kg/min for 5 min. Measurements and results: During a mean follow-up period of 63 ń 7 months (range, 49 to 75 months) 30 patients (39 p.c.) died and five patients (6 p.c.) underwent successful heart transplantations. Using multivariate regression analysis, the only significant factors related to fatal outcome or the need for cardiac transpantation were the following: (1) LV end-systolic volume of 150 mL after low-dose dobutamine infusion (odds ratio [OR], 2.2; confidence interval [CI], 1.2 to 4.1; p = 0.011); (2) no decrease of LV end-diastolic volume after dobutamine infusion (OR, 1.9; CI, 1.1 to 3.4; p = 0.031); (3) atrial fibrillation (OR, 2.7; CI, 1.4 to 5.3; p = 0.003); and (4) male gender (OR, 2.6; CI, 1.2 to 5.5; p = 0.017). A scoring system was proposed with one point assigned for each of the above-mentioned factors. The mortality rates for total scores of 0, 1, 2, 3, and 4 were 0 p.c., 19 p.c., 48 p.c., 83 p.c., and 100 p.c., respectively. Conclusion: The response of the LV to low-dose dobutamine infusion adds clinically valuable prognostic information to the evaluation of the patient with IDCM.


    362/2523

    Tytuł oryginału: Stimulatory effects of pituitary adenylate cyclase-activating polypeptide on inositol phosphates accumulation in avian cerebral cortex and hypothalamus.
    Autorzy: Nowak Jerzy Z., Pigulowska Aleksandra, Kuba Katarzyna, Zawilska Jolanta B.
    Źródło: Neurosci. Lett. 2002: 323 (3) s.179-182, il., bibliogr. 22 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • ptaki

    Streszczenie angielskie: This study has demonstrated that the short and long form of the pituitary adenylate cyclase-activating polypeptide (PACAP), i.e. PACAP27 and PACAP38, moderately but significantly, and in a concenration (0.5-5 ćM)-dependent manner, stimulated inositol phosphates (IPs) accumulation in myo-[3H]inositol-prelabeled cerebral cortical and hypothalamal slices of chick and duck, and in slices of rat cerebral cortex; both peptides had no effect on IPs formation in rat hypothalamus. Vasoactive intestinal peptide (VIP; 0.5-5 ćM) weakly enhanced IPs accumulation in chick hypothalamus, had no significant action in chick cerebral cortex (in fact there was a tendency to attenuate the IPs response in this tissue), and slighty, but significantly, inhibite the IPs accumulation in rat cerebral cortex. VIP showed no activity in rat hypothalamus. It is cincluded that tha stimulatory action of PACAP on phosphoinositide metabolism in avian cerebral cortex, similar to rat cerebral cortex, is mediated via phospholipase C-linked PAC1 type receptors. In chick hypothalamus, however, there may be a component of VPAC type receptors stimulating IPs formation.


    363/2523

    Tytuł oryginału: Long-term therapy with recombinant human erythropoietin decreases percentage of CD152+ lymphocytes in primary glomerulonephritis haemodialysis patients.
    Autorzy: Trzonkowski Piotr, Myśliwska Jolanta, Dębska-Ślizień Alicja, Bryl Ewa, Rachoń Dominik, Myśliwski Andrzej, Rutkowski Bolesław
    Źródło: Nephrol. Dial. Transplant. 2002: 17 (6) s.1070-1080, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 312,872

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Bacground. Recombinant human erythropoietin (rHuEpo) may affect the human immune system. The aim of the study was to examine changes in CD4+ and CD8+ T-cell subpopulations, the expression of the inhibitory molecule, CD152 on T lymphocytes and the levels of interleukins (IL), 2, 6, 10, 12 and tumour necrosis factor ŕ )TNFŕ) in primary glomerulonephritis chronic haemodialysis (HD) patients before and under rHuEpo treatment. Methods. Expression of T-cell surface molecules was measured in 14 HD patients ex vivo by flow cytometry of lymphocytes sampled from peripheral blood and in viutro using whole blood cell cultures stimulated either with phytohaemagglutinin (PHA) or with physiological as well as non-physiological does or rHuEpo. The concenrations of the cytokines were measured in the supernatans from non-or PHA-stimulated cultures using bioassays (IL2, IL6, TNFŕ) or ELISA test (IL10, IL12). Results. Compared with findings before the start of rHuEpotherapy the CD4+/CD8+ ratio increased after 1 year of follow-up, whereas the percentage of CD152+ peripheral blood lymphocytes decreased. The increase of the CD4+/CD8+ rtio was dependent on a decrease of the percentage of CD8+ cells. The decrease of CD152+ population affected mainly CD8+ CD152+ cells. All these effects became apparent after 6 months of rHuEpo treatment. In vitro stimulation of whole blood cultures revealed that the addition of PHA up-regulated the percentage of CD152+ lymphocytes, while physiological concentrations of rHuEpo decreased the percentage of CD8+ 152+ T cells...


    364/2523

    Tytuł oryginału: Carp erythrocyte lipids as a potential target for the toxic action of zinc ions.
    Autorzy: Gabryelak Teresa, Akahori Anna, Przybylska Maria, Jóźwiak Zofia, Brichon Gerard
    Źródło: Toxicol. Lett. 2002: 132 (1) s.57-64, il., tab., bibliogr. s. 63-64
    Sygnatura GBL: 306,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The effects of zinc on the lipid components of carp erythrocytes (Cyprinus carpio L.) were studied on red blood cells exposed to ZnSO4 (0.01 - 1 mM) for 20 h. The temperatures of the incubation medium were 5 and 20řC for carp collected in winter and summer, respectively. It was observed that increase in the concentration of metal ions in the medium led to significant changes in the content of the main phospholipid classes. Zinc induced the reduction of phosphatidylcholine as well as the increase in the content of phosphatidylserine and phosphatidylinositol. A marked increase in the levels of malondialdehyde and conjugated dienes was also found both in the cells and the incubation medium. Moreover, elevated Zn concentrations caused alterations in the erythrocyte plasma membrane fluidity, estimated by measuring the fluorescence of 1-[4-trimethylaminophenyl]-6-phenyl-1,3,5-hexatriene and 12-[9-anthroyloxy]stearic acid, located on the surface and in the hydrophobic regions of the lipid bilayer. This study in vitro confirmed that higher concentrations of zinc ions induce marked changes in the composition and structure of membrane lipids in carp erythrocytes.


    365/2523

    Tytuł oryginału: Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system.
    Autorzy: Widy-Tyszkiewicz Ewa, Piechal Agnieszka, Gajkowska Barbara, Śmiałek Mieczysław
    Źródło: Toxicol. Lett. 2002: 131 (3) s.203-214, il., tab., bibliogr. s. 213-214
    Sygnatura GBL: 306,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning task. Locomotor disturbances were not the cause of the observed effects. Ultrastructural observations showed neuropathological changes in hippocampus subfields and prefrontal cortex with swelling of synapses, astrocytes and astrocytic processes around the vessels in the cerebral cortex neuropil. Severity of the observed changes in glial-neuronal unit was in correlation with the extent of learning impairment. A direct injury of Schwann cells with the secondary myoclasis was noted in the sciatic nerve. Our results indicate that acute treatment with sodium tellurite results in impairment of learning and spatial memory.


    366/2523

    Tytuł oryginału: Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production.
    Autorzy: Tada Hiroyuki, Sugawara Shunji, Nemoto Eiji, Takahashi Nobuhiro, Imamura Takahisa, Potempa Jan, Travis James, Shimauchi Hidetoshi, Takada Haruhiko
    Źródło: Infect. Immun. 2002: 70 (6) s.3304-3307, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 305,564

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.


    367/2523

    Tytuł oryginału: Fold-recognition analysis predicts that the Tag protein family shares a common domain with the helix-hairpin-helix DNA glycosylases.
    Autorzy: Bujnicki Janusz M., Rychlewski Leszek
    Źródło: DNA Repair 2002: 1 (5) s.391-395, il., bibliogr. 30 poz.
    Sygnatura GBL: 304,952

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: The Escherichia coli protein Tag is traditionally regarded as an archetype of one of four classes of N-alkylpurine DNA glycosylases. However, its structure and phylogenetic relationship to other glycosylases emains a mystery. Fold-recognition and sequence profile analyses suggest that Tag shares the catalytic domain with helix-hairpin-helix (HhH) glycosylases such as MutY, AlkA and EndoIII, but its N- and C-termini together form a unique His2Cys2 cluster. The findings presented in this paper provide insight into sequence-structure-function relationships in the Tag family and should aid in a more precise definition of the common core of the HhH superfamily of glycosylases involved in DNA repair.


    368/2523

    Tytuł oryginału: International Journal of Cardiology
    Tytuł angielski: Verapamil improves the pacing-induced vasodilatation in symptomatic patients with hypertrophic cardiomyopathy.
    Autorzy: Dimitrow Paweł Petkow, Krzanowski Marek, Grodecki Janusz, Małecka Barbara, Lelakowski Jacek, Kawecka-Jaszcz Kalina, Szczeklik Andrzej, Dubiel Jacek S.
    Źródło: Int. J. Cardiol. 2002: 83 (3) s.239-247, tab., bibliogr. 52 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The purpose of the study was to assess the effect of varapamil on the response of diastolic coronary flow velocity and coronary vascular resistance to pacing in symptomatic patients with hypertrophic cardiomyopathy. In 14 patients with hypertrophic cardiomyopathy, the coronary flow velocity was detected in the left anterior descending coronary artery using transthoracic Doppler echocardiography. The peak diastolic coronary flow velocity and coronary and coronary vascular resistance was measured at baseline and during pacing. Changes of these parameters induced by the pacing (expressed as the percentage of baseline values) were compared on varapamil treatment and after verapamil withdrawal. The same measurements were obtained in ten control subjects. The results show that, in hypertrophic cardiomyopathy patients, increase in coronary flow velocity during pacing was significantly higher on than off varapamil therapy (64.8 ń 32.5 vs. 41.1 ń 21.3 p.c., P 0.05). In control subjects, pacing-induced increase in coronary flow velocity was comparable to changes in coronary flow velocity in hypertrophic cardiomyopathy patients receiving verapamil (80.2 ń 18.4 vs. 64.8 ń 32.5 p.c., P 0.05). After verapamil withdrawal in hypertrophic cardiomyopathy patients, coronary flow velocity increase during pacing was significantly lower than in control subjects (41.1 ń 21.3 vs. 80.2 ń 18.4 p.c., P 0.05). During pacing the coronary vascular resistance decreased more on verapamil than after drug withdrawal (-34.7 ń 11.7 vs. -24.6 ń 12.9 p.c., P 0.05). In control subjects the coronary...


    369/2523

    Tytuł oryginału: Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats.
    Autorzy: Borowicz Kinga K., Kleinrok Zdzisław, Czuczwar Stanisław J.
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (3) s.225-233, il., tab., bibliogr. s. 232-233
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: There is evidence that some calcium (Ca2+) channel inhibitors enhance the protective activity of antiepileptic drugs. Since clinical trials have not provided consistent data on this issue, the objective of this study was to evaluate the interaction of a dihydropyridine, niguldipine, with conventional antiepileptics in amygdala-kindled rats. Niguldipine (at 7.5 but not at 5 mg/kg) displayed a significant anticonvulsant effect, as regards seizure and afterdisharge durations in amygdala-kindled convulsions in rats, a model of complex partial seizures. No protective effect was observed when niguldipine (5 mg/kg) was combined with antiepileptics at subeffective doses, i.e. valproate (75 mg/kg), diphenylhydantoin (40 mg/kg), or clonazepam (0.003 mg/kg). Unexpectedly, the combined treatment of niguldipine (5 mg/kg) with carbamazepine (20 mg/kg) or phenobarbital (20 mg/kg) resulted in a proconvulsive action. BAY k-8644 (an L-type Ca2+ channel activator) did not modify the protective activity of niguldipine (7.5 mg/kg) or the opposite action of this dihydropyridine (5 mg/kg) in combinations with carbamazepine or phenobarbital. A pharmacokinetic interaction is not probable since niguldipine did not affect the free plasma levels of the antiepileptics. These data indicate that the opposite actions of niguldipine alone or combined with carbamazepine (or phenobarbital) were not associated with Ca2+ channel blockade. The present results may argue against the use of niguldipine as an adjuvant antiepileptic or for cardiovascular reasons in patients with complex partial seizures.


    370/2523

    Tytuł oryginału: Toxicology Letters
    Tytuł angielski: Peripheral blood lymphocytes and selected serum interleukins in workers operating X-ray equipment.
    Autorzy: Hrycek Antoni, Czernecka-Micińska Aleksandra, Kłuciński Piotr, Badowski Roman
    Źródło: Toxicol. Lett. 2002: 132 (2) s.101-107, tab., bibliogr. s. 106-107
    Sygnatura GBL: 306,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • radiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: The objective of these studies was to determine the effect of low X-ray doses on peripheral blood lymphocytes in the workers operating X-ray equipment. In 30 workers and 18 persons who constituted the control group the absolute number of peripheral blood lymphocytes, the number of T CD4+ and T CD8+ lymphocytes, the ratio CD4+/CD8+ and the concentration of serum interleukins (IL-2, IL-4, IL-6) were tested. Subgroups with respect to sex and employment period were selected. A significant increase in IL-2 concentration in workers as compared to controls was observed and significantly decreased IL-4 level in operating X-ray equipment was revealed. The lowest levels of IL-4 were noted in the women subgroup. A high positive, statistically significant correlations between the number of lymphocytes and the concentration of IL-2 and the level of IL-4 were observed. Moreover, our studies revealed that lymphocyte number and interleukin concentrations in serum of X-ray operators do not depend on the assumed ranges of the length of employment period.


    371/2523

    Tytuł oryginału: Left ventricular true aneurysm without coronary artery occlusion - a case study.
    Tytuł polski: Tętniak prawdziwy lewej komory serca bez zmian w naczyniach wieńcowych - opis przypadku.
    Autorzy: Sadowski Jerzy, Wierzbicki Karol, Wójcik Sławomir, Wróbel Krzysztof
    Źródło: Prz. Lek. 2002: 59 (3) s.190-192, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie polskie: Wstęp: Tętniak prawdziwy lewej komory serca jest zdefiniowany jako wyodrębniona struktura w obrębie lewej komory serca, w której mięsień serca został zastąpiony tkanką włóknistą, z typową dyskinezą w czasie skurczu. Pełnościenny zawał serca z zamknięciem tętnicy zstępującej przedniej jest najczęstszą przyczyną powstania tętniaka prawdziwego lewej komory serca. Opis przypadku: 51 letni mężczyzna po zawale ściany dolno-bocznej przed 6 laty, został przyjęty w październiku 2001 roku do oddziału intensywnej terapii w Szpitalu Rejonowym z powodu epizodu zatrzymania krążenia w mechanizmie migotania komór w przebiegu powtórnego zawału ściany dolno-bocznej. Po opuszczeniu szpitala pacjent nie powrócił do pracy, odczuwał zmęczenie i duszność przy wysiłku. Wykonana rok później koronarografia (wcześniej chory nie wyrażał zgody na diagnostykę inwazyjną) ujawniła preawidłowy obraz naczyń wieńcowych z recesywną prawą tętnicą wieńcową. Lewa tętnica wieńcowa była szeroka z prawidłowym przepływem kontrastu. W wentrykulografii stwierdzono duży dyskinetyczny tętniak prawdziwy lewej komory serca w okolicy koniuszka wypełniony przyścienną skrzepliną. Frakcja wyrzutowa lewej komory wynosiła 30 proc. Chory został zakwalifikowany do aneurysmectomii. Śródoperacyjnie stwierdzono duży tętniak (8 cm) okolicy oniuszka, z którego usunięto świeżą skrzeplinę o wadze 9 g. Wykonano aneurysectomię metodą Stoneye'a. W badaniu histopatologicznym wycinka ściany tętniaka stwierdzono typowe włóknienie bez ...

    Streszczenie angielskie: Background: Left ventricular true aneurysm is described as distinct area of the left ventricular wall with systolic dyskinesia where typical myocardial structure is replaced with fibrous tissue. Transmural infarction following occlusion of left anterior descending coronary artery is the most common cause of formation of the left ventricular aneurysm. Case report: A 51-year old white male, with the history of inferolateral wall myocardial infaction 6 years ago was admitted to the emergency department at the local hospital last year because of sudden cardiac arrest due to ventricullar fibrillation in the course of inferolated myocardial infarction. Later on the patient did not come back to work, felt very weak and had dyspnea on mild exertion. Coronary angiogram performed one year later (the patient refused coronary angiography examination at the time of myocardial infarction) showed normal coronary arteries with a recessive right coronary artery. The left coronary artery was wide with normal contrast flow. Ventriculography showed large, true dyskinetic aneurysm with mural thrombus in the apical segment of the left ventricular wall. Left ventricular ejection fraction was 30 p.c. Patient was qualified for the aneurysmectomy. A large dyskinetic aneurysm (8 cm) of the apical and anterolateral segment of the left ventricular wall was detected intraoperatively. A fresh thrombus weighing 9 g was evacuated from the inside of the aneurysm. Stoney's aneurysmectomy was ...


    372/2523

    Tytuł oryginału: Melanin potentiates gentamicin-induced inhibition of collagen biosynthesis in human skin fibroblasts.
    Autorzy: Wrześniok Dorota, Buszman Ewa, Karna Ewa, Nawrat Piotr, Pałka Jerzy
    Źródło: Eur. J. Pharmacol. 2002: 446 (1/3) s.7-13, il., bibliogr. s. 12-13
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: One of the recognized side effects of gentamicin is ototoxicity. The mechanism underlying the organ specificity of this side effect of gentamicin has not been fully established. In view of the fact that a number of pharmacologic agents are known to from complexes with melanin and melanin is an abundant constituent of the inner ear tissues, we determined whether gentamicin interacts with melanin and how this process affects the biosynthesis of collagen in cultured human skin fibroblasts. Our results indicate that gentamicin forms comples with melanin. The amount of gentamicin bound to melanin increases with increasing of initial drug concentration. The Scatchard plot analysis of drug binding to melanin showed that at least two classes of independent binding sites are implicated in gentamicin-melanin complex formation: one class with an association constant K1 ~ 4 x 10**3 M**-1, and the second class with an association constant K2 ~ 3 x 10**2 M**-1. The number of total binding sites (n1 + n2) was calculated as about 1.36 ćmol gentamicin per 1 mg melanin. We have suggested that prolidase, an enzyme involved in collagen metabolism, may be one of the targets for gentamicin-induced inhibition of collagen biosynthesis. We found that gentamycin-induced inhibition of prolidase activity (IC50 ~ 100 ćM) and collagen biosynthesis (IC50 ~ 100 ćM). At this concentration of gentamicin, DNA biosynthesis in human skin fibroblasts was inhibited only by about 30 p.c. Melanin at 100 ćg/ml produced about 25 p.c. inhibition of DNA synthesis and about 30 p.c. inhibition of prolidase activity, ...


    373/2523

    Tytuł oryginału: Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives.
    Autorzy: Alibert Sandrine, Santelli-Rouvier Christiane, Pradines Bruno, Houdoin Carole, Parzy Daniel, Karolak-Wojciechowska Janina, Barbe Jacques
    Źródło: J. Med. Chem. 2002: 45 (15) s.3195-3209, il.,tab., bibliogr. 47 poz.
    Sygnatura GBL: 312,133

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca doświadczalna

    Streszczenie angielskie: To suggest a mechanism of action for drugs capable to reverse the chloroquine resistance, a new set of 9,10-dihydro-9,10-ethano and ethenoanthracene derivatives was synthesized and compounds were tested with the aim to assess their effect on chloroquine susceptibility in Plasmodium falciparum resistant strains. With respect to this, reversal of resistance and change in drug accumulation were compared. Structure - activity relationship and molecular modeling studies made it possible to define a pharmacophoric moiety for reversal agents and to propose a putative model of interaction with some selected amino acids.


    374/2523

    Tytuł oryginału: Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus.
    Autorzy: Pawlak Robert, Skrzypiec Anna, Sulkowski Stanisław, Buczko Włodzimierz
    Źródło: Neurosci. Lett. 2002: 327 (2) s.83-86, il., bibliogr. 19 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Chronic ethanol abuse leads to degenerative changes in the hippocampus, which may result in subsequent cognitive impairment. Since the hippocampus retains the ability to produce neurons throught adulthood, in the present study we examined if ethanol-induced neuronal loss could be counterbalanced by cell proliferation in mouse dentate gyrus (DG). A total of 14 days of ethanol administration resulted in marked increase in cells positive for TdT-mediated dUTP nick-end labeling in all hippocampal regions studied, indicating that neurons die throughout the hippocampus by apoptotic mechanism. However, cresyl violet staining revealed approximately 20 p.c. neuronal loss following ethanol administration in CA1 and CA2 fields (P 0.01 and P 0.05, respectively), but not in DG. At the same time ethanol caused 2-fold increase in the number of proliferating cells in subgranular zone of DG. Thus, long-term ethanol intoxication causes permanent damage to CA1 and CA2, but not to DG which can be counterbalanced by ongoing neurogenesis.


    375/2523

    Tytuł oryginału: Immune reconstitution after haematopoietic cell transplantation in children: immunophenotype analysis with regard to factors affecting the speed of recovery.
    Autorzy: Kalwak Krzysztof, Gorczyńska Ewa, Toporski Jacek, Turkiewicz Dominik, Słociak Małgorzata, Ussowicz Marek, Latos-Grażyńska Elżbieta, Król Marzena, Bogusławska-Jaworska Janina, Chybicka Alicja
    Źródło: Br. J. Haematol. 2002: 118 (1) s.74-89, il., tab., bibliogr. s. 87-89
    Sygnatura GBL: 303,964

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • transplantologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Immune reconstitution was studied prospectively in 66 children who underwent 77 haematopoietic cell transplantations (HCT): 46 autologous HCTs in 39 patients and 31 allogeneic HCTs in 27 patients. We studied the dynamic analysis of immune recovery with regard to potential factors affecting its speed, including age, type of HCT, diagnosis, graft-versus-host disease (GvHD) and cytomegalovirus (CMV) infection reactivation. Absolute counts of different lymphocyte subsets and immunoglobulin serum levels were determined in peripheral blood of patients on d -7 and +16, and then at various intervals up to 24 months post transplant. Common patterns of immune recovery after both allogeneic and autologous HCT were identified: (I) CD4+CD45RO+ peripheral T-cell expansion on d +16; (II) inverted CD4+:CD8+ ratio from D+30 onwards; (III) rapid natural killer (NK) cell (CD16 ń CD56+) count normalization. We observed prolonged T-cell lymphopenia (CD3+, CD3+CD4+, CD4+CD45RA+) until 24 months after autologous HCT, whereas in the allogeneic setting CD3+CD4+ cells, including naive CD45RA+ cells, returned to normal values at 9 months post transplant. Age 10 years and coexistence of GvHD and CMV reactivation were associated with a substantial delay in T- (CD4+, including CD45RA+) and B-cell recovery after allogeneic HCT. Multidrug GvHD prophylaxis resulted in impaired T-(CD4+, CD4+CD45RA+) and B-cell reconstitution only in the early phase after allogeneic HCT (up to 4 months). Our results demonstrated that T-cell recovery was severely impaired in children after autologous HCT...


    376/2523

    Tytuł oryginału: Correlation of blood lymphocyte CTLA-4 (CD152) induction in Hodgkin's disease with proliferative activity, interleukin 2 and interferon-gamma production.
    Autorzy: Kosmaczewksa Agata, Frydecka Irena, Boćko Dorota, Ciszak Lidia, Teodorowska Renata
    Źródło: Br. J. Haematol. 2002: 118 (1) s.202-209, il., tab., bibliogr. s. 207-209
    Sygnatura GBL: 303,964

    Hasła klasyfikacyjne GBL:
  • immunologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Expression of the downregulatory CTLA-4 molecule was determined on unstimulated and anti-CD3+ recombinant interleukin 2 (rIL-2)-stimulated peripheral blood T cells in Hodgkin's disease (HD) and correlated with the T-cells' proliferative activity, IL-2 and interferon (IFN)-gamma production. There was a negligible percentage of CTLA-4+/CD3+ cells before culture. The mean percentage of CTLA-4+/CD3+ lymphocytes increased gradually, peaked after 72 h of stimulation and returned to basal values after 96 h of stimulation. The mean proportion of CTLA-4+/CD3+ cells from untreated patietns was significantly higer after 24, 48 and 72 h of stimulation comppared with controls. The mean percentage of CTLA-4+/CD3+ cells from patietns in clinical remission (CR) was lower than that of untreated patients, but remained significantly higher compared with controls. Lymphocytes from untreated HD patients showed impaired proliferative activity, IL-2 and IFN-gamma production compared with controls. The proliferative activity of the lymphocytes, IL-2 and IFN-gamma production remained significantly lower in CR compared with controls. The proportion of CTLA-4+/CD3+ cells negatively correlated with proliferative activity, IL-2 and IFN-gamma production in HD patients and controls. However, some untreated patients as well as patients in CR with normal mean fluorescence intensity values of CTLA-4 showed unimpaired T-cell function tests. Our study provides the first evidence of an increased expression of downregulatory CTLA-4 molecule on stimulated T-cells in HD, which could be one of the mechanisms of immune deficiency in this disease.


    377/2523

    Tytuł oryginału: Photoreactivity of aged human RPE melanosomes: a comparison with lipofuscin.
    Autorzy: Różanowska Małgorzata, Korytowski Witold, Różanowski Bartosz, Skumatz Christine, Boulton Mike E., Burke Janice M., Sarna Tadeusz
    Źródło: Invest. Ophthalmol. Vis. Sci. 2002: 43 (7) s.2088-2096, il., bibliogr. 57 poz.
    Sygnatura GBL: 311,976

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Purpose. To determine whether aging is accompanied by changes in aerobic photoreactivity of retinal pigment epithelial (RPE) melanosomes isolated from human donors of different ages, and to compare the photoreactivity of aged melanosomes with that of RPE lipofuscin. Methods. Human RPE pigment granules were isolated from RPE cells pooled into groups according to the age of the donors. Photoreactivity was determined by blue-light-induced oxygen uptake and photogeneration of reactive oxygen species. Short-lived radical intermediates were detected by spintrapping, hydrogen peroxide by an oxidase electrode, singlet oxygen by cholesterol assay, and lipid hydroperoxides by iodometric assay. Results. Blue-light photoexcitation of melanosomes resulted in age-related increases in both oxygen uptake and the accumulation of superoxide anion spin adducts. The efficiencies of these processes, however, were still significantly lower than that induced by photoexcited lipofuscin. During irradiation of melanosomes, a substantial amount of oxygen was converted into hydrogen peroxide, whereas for lipofuscin, hydrogen peroxide accounted for not more than 3 p.c. of oxygen consumed. In contrast to lipofuscin, photoexcited melanosomes did not substantially increase the rate of oxidative reactions in the presence of polyunsaturated lipids of albumin. However, oxygen uptake was significantly elevated in the presence of ascorbate. Thus, the rate of photo-induced oxygen uptake in samples containing both ascorbate and melanosomes approached that observed in lipofuscin samples...


    378/2523

    Tytuł oryginału: Human papillomavirus and oncogenesis: critical evaluation of recent findings.
    Autorzy: Majewski Sławomir, Jabłonska Stefania
    Źródło: Int. J. Dermatol. 2002: 41 (6) s.319-320, bibliogr. 16 poz.
    Sygnatura GBL: 305,645

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie


    379/2523

    Tytuł oryginału: Association of asthma and total IgE levels with human leucocyte antigen-DR in patients with grass allergy.
    Autorzy: Woszczek G[rzeogrz], Kowalski M[arek] L., Borowiec M[aciej]
    Źródło: Eur. Respir. J. 2002: 20 (1) s.79-85, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 312,824

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Exposure to grass pollens during the pollen season, reveals in sensitive patients symptoms of allergic rhinitis, conjunctivitis and/or bronchial asthma. It is not well understood why, in some patients, only symptoms of rhinits occur while in others similar exposure causes symptoms of asthma and rhinitis. An association study is reported here, where the possible contribution of human leucocyte antigen (HLA)-DR gene polymorphisms to differential phenotypic expression of symptoms in patients with grass-pollen allergy was determined. HLA-DR genotyping was performed by the polymerase chain reaction with the sequence-specific primers method in 82 patients with symptoms of seasonal allergic rhinitis and/or bronchial asthma and 52 healthy nonatopic control subjects. A significant association was found between HLA-DRB1*02, B5* haploytpe and asthma phenotype in patients with grass-pollen allergy when compared to patients with rhinitis only. Significantly higher total serum immunoglobulin E levels were observed in patients with HLA-DRB1*01 alleles in comparison to patients without these alleles. The data in this study suggest that human leucocyte antigen-DR locus, or other genes in linkage disequilibrium, may play an important role in asthma phenotype expression in patients with grass-pollen allergy as well as in determining total immunoglobulin E levels in these patients.


    380/2523

    Tytuł oryginału: Penicillin-binding proteins of Listeria monocytogenes - a re-evaluation.
    Autorzy: Korsak Dorota, Zawadzka Joanna J., Siwińska Maria E., Markiewicz Zdzisław
    Źródło: Acta Microbiol. Pol. 2002: 51 (1) s.5-12, il., tab., bibliogr. [23] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Intact Listeria monocytogenes cells or membranes isolated from them were treated with [3H]penicillin to allow identification of the penicillin binding proteins (PBPs) located in the cytoplasmic membrane. In the former case the PBPs were released from the cells following disruption of the cell wall murein with Listeria monocytogenes bacteriophage lysin. The procedure described by Dougherty et al. (1996) for Escherichia coli, with some modifications, was used to evaluate the Mrs of the individual PBPs and allowed direct quantitation of their copy number.


    381/2523

    Tytuł oryginału: Diagnostic methods for detection of respiratory RNA viruses.
    Autorzy: Filipowicz Elżbieta
    Źródło: Acta Microbiol. Pol. 2002: 51 (1) s.13-21, il., bibliogr. [32] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: This article is a comprehensive description of diagnostic methods for detection of RNA respiratory viruses - respiratory syncytial virus RSV, influenza A and B viruses, parainfluenza 1, 2 and 3 viruses, coronaviruses and rhinoviruses - from cell culture to molecular biology methods. Both patients and medical personnel appear to be at risk of viral infection, specially during the winter season. Moreover, many health care units lack viral diagnostic facilities: therefore, it is essential for medical personnel to have an understanding of the etiology, mechanisms of transmission and of all disposable today diagnostic methods of RNA respiratory viruses. Patients at greatest risk of acquring nosocomial viral respiratory disease are children, patients with immunodeficiency and patients treated in intensive care.


    382/2523

    Tytuł oryginału: Autoaggregation, hydrophobic, and hydrophylic properties of Moraxella catarrhalis strains.
    Autorzy: Janicka Grażyna, Mikucka Agnieszka, Sękowska Alicja, Zwierzchlewski Tomasz, Wróblewski Marcin
    Źródło: Acta Microbiol. Pol. 2002: 51 (1) s.23-30, il., bibliogr. [27] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • in vitro

    Streszczenie angielskie: The hydrophobicity of the bacterial cell surface was evaluated via the salt aggregation test (SAT) in 58 strains (19 from the lower and 39 from the upper respiratory tracts) of Moraxella catarrhalis in hospitalized patients aged 25 to 65. Based on the SAT results, the strains were divided into three groups: autoaggregating (highly hydrophobic), hydrophobic, and hydrophilic. At a temperature of 37řC, the autoaggregating, hydrophobic or hydrophilic properties did not depend on the choice of a medium, whereas at 22řC the investigated properties did (p 0.0001). Taking into account the origin of the strains (lower vs. upper respiratory tract), it was found that: in the strains cultivated in liquid medium, both highly hydrophobic, hydrophobic and hydrophilic surfaces were present with a comparative frequency, independent of the strain isolated site and cultivation conditions; strains with highly hydrophobic and hydrophobic surfaces, but only those cultivated on solid media at 22řC, were much more often isolated from sputum rather than from nose and throat swabs, whereas a ststistically significant incidence of hydrophilic strains was found in samples from the uppeer rather than lower respiratory tract.


    383/2523

    Tytuł oryginału: A comparison of four susceptibility tests on Yersinia enterocolitica strains isolated from human and animal material.
    Autorzy: Woźniak-Kosek Agnieszka, Kawiak Jerzy
    Źródło: Acta Microbiol. Pol. 2002: 51 (1) s.31-37, il., tab., bibliogr. [14] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • in vitro

    Streszczenie angielskie: The results of antibiotic sensitivity tests are presented for 20 strains of Yersinia enterocolitica from human and animal material as well as for one commercial standard strain. Results obtained with four different methods of assays were compared. One of the methods used was flow cytometric Minimum Inhibitory Concentration (MIC) assay (FC-MIC). Results of all four tests were strains in the clinical surrounding are discussed.


    384/2523

    Tytuł oryginału: Evaluation of antiviral activity of different origin compounds by flow cytometry.
    Autorzy: Siennicka Joanna, Trzcińska Agnieszka, Kańtoch Mirosław
    Źródło: Acta Microbiol. Pol. 2002: 51 (1) s.79-83, il., bibliogr. [18] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Against many viral diseases caused for example by HSV, EBV, CMV, HIV, RSV, HCV for which vaccines are not available, chemiotherapeutics seem to have the principal significance. High progress in development of new antiviral compounds is observed. In addition to synthetic compounds a large number of naturally occuring substances have been shown to posses antiviral activity. One of such substances is tannic acid. In this study comparison of antiviral activity of tannic acid, acyclovir (ACV) and ganciclovir (GCV) against cytomegalovirus (CMV) is presented. The MRC5 cells infected with CMV and treated with different compounds were analyzed by flow cytometry and cythopatic effect inhibition test for inhibition of virus replication and by MTT assay for cytotoxity. It has been shown that tannic acid has antiviral activity against cytomegalovirus and that expression of virus antigens measured as median fluoroscence intensity (MFI) by flow cytometry can be used for evaluation of virus replication.


    385/2523

    Tytuł oryginału: Hepatic steatosis in patietns with hyperlipoproteinaemia - correlations between histological finding and lipid profile determined by ultracentrifugation.
    Tytuł polski: Stłuszczenie wątroby u osób z HLP - korelacja obrazu histopatologicznego i profilu lipidowego określanego za pomocą ultrawirowania.
    Autorzy: Tacikowski Tadeusz, Dzieniszewski Jan, Ciok Janusz, Nowicka Grażyna
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (2) s.155-161, tab., bibliogr. 41 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. W ostatnim okresie coraz częściej analizuje się problem stłuszczenia wątroby, wywołanego czynnikami innymi niż alkohol lub zakażenie wirusowe. Najczęściej dotyczy to stłuszczenia wątroby na skutek otyłości, cukrzycy i hiperlipoproteinemii (HLP). Choroba stłuszczeniowa wątroby (fatty liver disease) ma swój naturalny przebieg i można ją podzielić na cztery stadia: I - proste stłuszczenie, II - stłuszczenie z zapaleniem, III - stłuszczenie z wrotnym włóknieniem, IV - stłuszczeniowa marskość wątroby. Cel pracy. Ustalenie zależności między zaawansowaniem stłuszczenia wątroby w badaniu histopatologicznym punktatu wątroby a stężeniami cholesterolu i trójglicerydów w surowicy w poszczególnych frakcjach lipoprotein ocenianych za pomocą ultrawirowania. Materiał i metoda. Zbadano prospektywnie 30 chorych z różnymi typami HLP, u których w badaniu histopatologicznym stwierdzono cechy stłuszczenia wątroby. Stopień zaawansowania choroby stłuszczeniowej wątroby określano według podanej wcześniej klasyfikacji histopatologicznej. Z analizy wykluczono przypadki chorych, u których stwierdzano markery wirusowego uszkodzenia wątroby HBV i HCV oraz chorych pijących alkohol w ilości większej niż 200 g/miesiąc ( w przeliczeniu na czysty alkhol). Wyniki. W analizowanej grupie chorych 11 pacjentów miało proste stłuszczenie wątroby (36,7 proc.), 10 (33,3 proc.) stłuszczenie z zapaleniem, a 9 (30 proc.) stłuszczenie z wrotnym włóknieniem. Średnie stężenie TG stwierdzono w I typie ...

    Streszczenie angielskie: Background. In recent years the problem is ever more frequently analysed of hepatic steatosis caused by factors other than alcoholism or viral infection, mainly in obesity, diabetes mellitus and hyperlipoprotienaemia (HLP). Fatty liver disease has its natural history which can be divided into four stages: I - steatosis, simple fatty liver, II - steatosis with hepatitis or fatty liver hepatitis, or fatty liver hepatitis, III - fatty liver with portal fibrosis, IV - fatty cirrhosis. Objectives. Finding of correlations between advanced hepatic steatosis found in histological examination of liver biopsy specimen and serum concentrations of cholesterol and triglycerides in various lipoprotein fractions obtained by ultracentrifugation. Material and method. Thirty patietns with various HLP types were studied prospectively after finding in them hepatic steatosis in histological examination. The degree of hepatic steatosis was determined according to histopathological classification presented earlier. Cases with presence of virus hepatophaty markers HBV and HCV, and patietns with a history of alcohol drinking in amounts above 200 g of pure alcohol monthly were excluded from the study. Results. In the studied group 11 patietns had simple fatty liver (36.7 p.c.), ten had fatty liver hepatitis (33.3 p.c.) and mine had fatty liver with portal fibrosis (30 p.c.). The mean TG concentration found in type I of histological lesions (simple fatty liver) was 221.0 mg/100 mL, and it was ...


    386/2523

    Tytuł oryginału: Lipid peroxidation of cellular membranes following photodynamic therapy with photosensitizers: sulfoxaporphyrin, dithiaporphyrin and hematoporphyrin derivative.
    Tytuł polski: Peroksydacja lipidów błon komórkowych w następstwie terapii fotodynamicznej z użyciem fotouczulaczy: sulfoksaporfiryny, ditiaporfiryny oraz pochodnej hematoporfiryny.
    Autorzy: Ziółkowski Piotr, Symonowicz Krzysztof, Bronowicz Andrzej, Osiecka Beata J., Chmielewski Piotr, Latos-Grażyński Lechosław, Dzięgiel Piotr
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (2) s.181-186, il., tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie polskie: Wprowadzenie. Fotodynamiczna terapia (PDT) jest znaną metodą leczenia nowotworów złośliwych obejmującą stosowanie fotouczulaczy oraz światła o odpowiedniej długości fali. Mechanizmy działania PDT nie są całkowicie wyjaśnione, szczególnie gdy stosuje się nowe związki. Cel pracy. Celem pracy było sprawdzenie, czy nowe fotouczulacze w warunkach PDT mogą uszkadzać błony komórkowe i tym samym przyczyniać się do śmierci komórkowej. Materiał i metody. Sulfoksaporfiryna (OXA) i ditiaporfiryna (DTP) były podawane w iniekcjach dootrzewnowych myszom BALB/c uprzednio zaszczepionym mięsakiem włóknistym, BFS1. Stosowano dawki 2,5, 5,0 oraz 7,5 mg/kg w 0,9 p.c. Na Cl, a po upływie 24 godzin nowotwory naświetlano światłem o całkowitej dawce równej 50 lub 100J/cmý i długości fali wynoszącej 670 nm (OXA), 695 nm (DTP) oraz 627 nm (HpD). Po 30 minutach oraz po 6 i 48 godzinach myszy uśmiercano, pobierano nowotowory i poddawano je oznaczeniom w kierunku peroksydacji lipidów (LP). LP mierzono spektrofotometrycznie z użyciem zestawów dla malonylodialdehydu (MDA) i 4-hydroksyalkenów (4HNA). Wartości LP podawano w ćM. MDA+44HNA na gram tkanki. Wyniki. Stężenie LP dla poszczególnych fotouczulaczy nie różniło się znacząco i było zależne od stosowanej dawki fotodynamicznej. Najwyższe stężenia LP występowały po 6 godzinach od naświetlenia dawką 100 J/cmý (dawki fotodynamicznej. Najwyższe stężenia LP występowały po 6 godzinach od naświetlenia dawką 100 J/cmý (dawka preparatu - 7,5 mg/kg). W ...

    Streszczenie angielskie: Background. Photodynamic therapy (PDT) is known method of anticancer treatment involving application of photosensitizer and subsequent irradiation with light of appropriate wavelength. Mechanisms of PDT action are not completely elucidated, especially when new photosensitizers are applied. Objectives. Aim of study was checking whether new compounds in terms of PDT impair cellular membranes, theus facilitating cell death. Material and methods. Sulfoxaporphyrin (OXA) and dithiaporphyrin (DTP) were injected intraperitoneally to BALB/c mice transplanted with fibrosarcoma BFS1 in doses 2.5, 5.0, 7.5 mg/kg in 0.9 p.c. NaCl. After 24 hours tumors were irradiated at total doses 50 or 100 J/sq cm and wavelength 670 nm (OXA), 695 nm (DTP) and 627 nm (HpD). Following 30 minutes, 6 and 48 hours observation mice were sacrified, tumors excised, and processed for lipid peroxidation (LP). LP was spectrophotometrically measured using kits for malonyldialdehyde (MDA) and 4-hydroxyalkenes (4HNA). LP was given in ćM MDA+4 HNA/g of tissues. Results. Level of LP for particular photosensitizer did not very significantly. LP showed to be photodynamic dose-dependent (photosensitizer x light doses). The highest levels of LP occurred after 6 hours from light application at 100 J/sq cm (compound dose was 7.5 mg/kg). In such conditions, OXA-PDT resulted in 998. 15, DTP-PDT in 899.04 and HpD-PDT in 1137.36 ćM/g, whereas in controls it did not exceed 73.0 ćM/g. At lates time point (48 hrs) these ...


    387/2523

    Tytuł oryginału: Artificial peritoneum for the treatment of fecal/barium peritonitis - an expreimental study.
    Tytuł polski: Sztuczna otrzewna w leczeniu kałowo-barowego zapalenia otrzewnej - badania doświadczalne.
    Autorzy: Kielan Wojciech, Kozianka Juergen, Grzebieniak Zygmunt
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (2) s.193-199, il., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie polskie: Cel pracy. Celem pracy było zbadanie na modelu doświadczalnym zapalenia otrzewnej u świń, czy i w jaki sposób proces zapalny w jamie otrzewnej rozprzestrzenia się przez część przeponową otrzewnej ściennej i czy czynność resorpcyjną części przeponowej otrzewnej ściennej można zmniejszyć w sposób sztuczny, pokrywająć ją przyjętą do badań gąbką HYPOL - sztuczną otrzewną. Materiał i metody. Do doświadczenia użyto 19 świń, które podzielono na dwie grupy. 4 Świnie były grupą kontrolną (dwie z zapaleniem otrzewnej bez zakładania sztucznej otrzewnej oraz dwie z założoną sztuczną otrzewną, ale bez wywołanego zapalenia otrzewnej). 15 świń miało śródoperacyjnie wywołane kałowo-barowe zapalenie otrzewnej oraz założoną gąbkę HYPOL - sztuczną otrzewną pod kopułę przepony. Po śmierci świń sztuczna otrzewna oraz przepona były badane w mikroskopie elektronowym. Wyniki. Dwie świenie, które miały założoną sztuczną otrzewną bez wywołanego zapalenia otrzewnej, przeżyły operację bez powikłań. Zwierzęta, które miały wywołane zapalenie otrzewnej bez założenia sztucznej otrzewnej zmarły do 4 godzin po zabiegu. Świnie, ktróe miały wywołane zapalenie otrzewnej i założoną sztuczną otrzewną pod kopułą przepony przeżyły 6-16 godzin po operacji i czas ten był istotnie dłuższy niż u zwierząt bez założonej sztucznej otrzewnej. Gdy przepona nie była pokryta sztuczną otrzewną, dochodziło do całkowitego zniszczenia otrzewnej ściennej przepony z przechodzeniem kryształów siarczanu baru przez przeponę. W ...

    Streszczenie angielskie: Objectives. The study was intended to evaluate the pattern of spreading of intraabdominal sepsis through the diaphragm and to find out whether implantation of a polyurethane HYPOL sponge as an artificial peritoneum can reduce the spread of sepsis. Material and methods. In the experiment 19 swine were used in two groups: 4 as controls (2 with peritonitis without artificial peritoneum, two with artificial peritoeum but without peritonitis) and 15 animals that had fecal/barium peritonitis induced, and HYPOL sponge implanted under the diaphragm. When they died, the sponge and peritoneum were examined in scanning electron microscopy. Results. The swine that had artificial peritoneum implanted without peritonitis recovered normally. The animals that had peritonitis without implanting artificial peritoneum died within 4 hours. With peritonitis and diaphragmal peritoneum protected with HYPOL sponge, the time of survival was significantly longer. Where the artificial peritoneum was not used, diaphragmal peritoneum underwent complete destruction and barium sulfate crystals migrated through the diaphragm. With peritoenum protected with the HYPOL sponge, the mesothelium was preserved and migration of barium reduced. Conclusions. The evaluated artificial peritoenum, HPOL sponge, provides protection to the diaphragmal peritoneum in fecal/barium peritonitis. It acts as a mechanical fllter interfering with resortption and spread of the infection in peritonitis. HYPOL sponge might ...


    388/2523

    Tytuł oryginału: Adrenal gland myelolipoma - report of two cases.
    Tytuł polski: Mielolipoma nadnerczy - opis dwóch przypadków.
    Autorzy: Bronowicz Andrzej, Woźniak Zdzisław Michał, Ziółkowski Piotr, Sawicz-Birkowska Krystyna, Tarnawa Robert
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (2) s.263-265, il., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Przedstawiono dwa przypadki chorych z guzami typu mielolipoma zlokalizowanymi w nadnerczach. U jednego z pacjentów zmiana była jednostronna, u drugiego występowała w obu nadnerczach. Prawidłowe rozpoznanie tego rzadkiego guza zostało postawione po usunięciu chirurgicznym. Przedoperacyjna diagnostyka tego typu zmian jest trudna i prowadzi często do mylnych rozpoznań.

    Streszczenie angielskie: We report on adrenal gland myelolipoma: one uni- and second, bilateral. This very uncommon tumor was correctly diagnosed after surgical treatment. Preoperative, it always presents problems, thus often leading to misdiagnosis.


    389/2523

    Tytuł oryginału: The hobnail cell metaplasia of endosalpinx.
    Tytuł polski: Metaplazja hufnalowata w jajowodzie.
    Autorzy: Rabczyński Jerzy, Woźniak Zdzisław Michał, Ziółkowski Piotr, Hałoń Agnieszka
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (2) s.273-275, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie polskie: Komórki przybierające kształt gwoździ służących do mocowania podków do końskich kopyt stanowią element osobliwego obrazu spotykanego głównie w obrębie wyściółki nabłonkowej kobiecych narządów rodnych. Komórki hufnalowate są typowe dla wywodzących się z międzynercza raków jasnokomórkowych szyjki macicy, trzonu macicy i jajnika. Autorzy opisali rzadkie przypadki metaplazji hufnalowatej w jajowodzie w przebiegu pierwotnego raka surowiczego oraz przewlekłego zapalenia tego narządu.

    Streszczenie angielskie: The epithelial cells expressing nails with horse-shoe appearance are elements of various pathological disorders of female genital tracts. The hobnail type cells are very common for cervical, endometrial and ovarian clear cells carcinomas derived from mesonephros. Similar appearance is demonstrated in some nonneoplastic disorders of endometrium and endosalpinx. Rare case of hobnail cell metaplasia of endosalpinx in primary serous cell carcinoma and salpingitis has been described.


    390/2523

    Tytuł oryginału: Changes in BRCA1 gene in patients with familial breast cancer in the Warsaw region of Poland.
    Tytuł polski: Zmiany w genie BRCA1 u chorych na rodzinnego raka sutka, leczonych w Centrum Onkologii w Warszawie.
    Autorzy: Paszko Zygmunt, Skasko Elżbieta, Wiśniewska Alicja, Konopka Bożena, Kluska Anna, Jagielska Agnieszka, Wieczorek Ewa, Janiec-Jankowska Aneta, Niwińska Anna, Pieńkowski Tadeusz, Mazur Słwomir
    Źródło: Nowotwory 2002: 52 (2) s.97-103, il., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Spośród przeszło 500 kobiet chorych na raka sutka, leczonych w Centrum Onkologii w Warszawie, wyselekcjonowano 52 probantki, które były obarczone rodzinnym występowaniem kilku raków sutka i innych nowotworów. Materiałem badawczym było DNA, izolowane z leukocytów krwi obwodowej. Procedurą PCR-SSCP posługiwaliśmy się w celu poszukiwania mutacji we wszystkich kodujących białko eksonach genu BRCA1. Fragmenty podejrzane o obecność muatcji poddawano sekwencjonowaniu. U 36 probantek w genie BRCA1 wykryto 11 rodzajów zmian w eksonach i 5 rodzajów zmian w intronach. U 19 (36,5 proc.) probantek nie wykryto w genie BRCA1 żadnych zmian. Wśród zmian eksonowych trzy z nich powszechnie uznawane są za mutacje patogenne: 5382insC (3 rodziny; 6 przypadków), T300G (2 probantki), 3819del5 (1 probantka). Spośród zmian intronowych zmiana IVS6 + 28 (C - A) podejrzewana jest przez nas o patogenne właściwości, gdyż umiejscowiona jest w obszarze intronu, który bierze udział w składaniu eksonów. Występowała ona u trzech sióstr (dwie chore i jedna zdrowa). Pozostałych 8 zmian, wykrytych w eksonach 11, 13 i 16 (A1186G, C2201T T2430C, C2731T, A3232G, A3668G, T4427C, A4956G), to polimorfizmy. Jedna z nich - A1186G występowała jako zmiana heterozygotyczna częściej u chorych na raka sutka (18,8 proc.), niż u kobiet zdrowych (4 proc.). Wśród badanych chorych zaobserwowaliśmy w eksonach genu BRCA1 częste nagromadzanie się u tej samej chorej kilku (3-6) polimorfizmów. Dwie heterozygotyczne zmiany (T300G i A1186G), znalezione w DNA z krwi dwóch nie spokrewnionych chorych, utraciło swą heterozygotyczność w DNA izolowanym z guza.

    Streszczenie angielskie: 52 patient-probands with a family history of breast cancer and other tumours were selected from among 500 breast cancer patietns trated at the Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology. We studied DNA isolated from peripheral blood. The PCR-SSCP procedure was used for seeking mutations in all protein coding exons of the BRCA1 gene. Fragments suspected of mutation presence were subjected to sequencing. In 36 probands of the BRCA1 gene 11 types of changes were found in exons and 5 types in introns. In 19 (36.5 p.c.) probands no changes were detected within the BRCA1 gene. Among exon changes 3 were ones generally regarded as pathogenic mutations: 5382insC (3 families; 6 cases), T300G (2 probands), 3819delGTAAA (1 proband). Among intron changes we suspect the IVS6 +28 (C - mA) change to be pathogenic, since it is present in intron area participating in exons splicing. It was found in three sisters (two had breast cancer, one was healthy). The remaining 8 changes were disclosed in exons 11, 13 and 16 (A1186G, C2201T, T2430C, C2731T, A3232G, A3668G, T4427C, A4956G) and regarded as polymorphisms. One of them, A1186G, was, as a heterozygotic change, more frequent in breast cancer cases (18.8 p.c.) than in healthy women (4 p.c.). We observed frequent presence of several types of polymorhisms (3-6) in BRCA1 gene exons. Two heterozygotic changes (T300G and A1186G) inthe blood DNA of two unrelated patients lost their heterozygosity in tumour DNA.


    391/2523

    Tytuł oryginału: Survival and pattern of failure after postoperative radiation therapy for medulloblastoma in adult patients.
    Tytuł polski: Ocena wyników i przyczyn niepowodzeń pooperacyjnego napromieniania dorosłych chorych na rdzeniaka płodowego.
    Autorzy: Żółciak Agnieszka, Kępka Lucyna, Fijuth Jacek, Leszczyk Czesława
    Źródło: Nowotwory 2002: 52 (2) s.104-109, il., tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Cel. Ocena wyników pooperacyjnej radioterapii 27 dorosłych chorych na rdzeniaka płodowego (modulloblastoma). Materiał i metoda. Poddano analizie 27 choorych na rdzeniaka płodowego, leczonych napromienianiem w II Zakładzie Teleradioterapii Centrum Onkologii im. M. Skłodowskiej-Curie, w latach 1984-2000. Dwudziestu sześciu chorych napromieniono na oś móżgowo-rdzeniową (mediana - 33,6 Gy), podwyższając dawkę na tylny dół czaszki do 55 Gy. Jeden chory był napromieniony paliatywnie na móżg. Chorym nie podawano chemioterapii jako pierwotnego leczenia. Przeprowadzono analizę niepowodzeń leczenia, przeżycia całkowitego, przeżycia bez nawrotu choroby i przeżycia po wznowie (PPW). Oceny czynników rokowniczych dokonano w analizie jednowymiarowej, włączając wiek, stan ogólny, stan neurologiczny, zakres resekcji, lokalizację guza (robak versus półkula móżdżku), obecność desmoplazji i obecność zastawki w komorze mózgu. Do analizy nie włączono stopnia zaawansowania ze względu na brak wykonywania wszystkich obowiązujących badań wyjściowych (rezonans rdzenia kręgowego i punkcja lędźwiowa). Wyniki. Przeżycie 5- i 10-letnie wyniosło odpowiednio 55 oraz 44 proc. Prawdopodobnieństwo 5- i 10-letniego przeżycia bez nawrotu choroby wynosiło odpowiednio 44 i 31 proc. Wiek okazał się jedynym istotnym czynnikiem prognostycznym w analizie jednowymiarowej. Pięcioletnie przeżycie całkowite dla chorych w wieku poniżej 30 lat wynosiło 40 proc., a dla chorych w wieku 30 i więcej lat 90 proc. (p = ...

    Streszczenie angielskie: Aim. To present the results of postopeorative radiotherapy in 27 adult patients with medulloblastoma and to design future management strategies. Material and methods. 27 patients with medulloblastoma were treated between 1984 and 2000, of whom 26 received craniospinal irradiation (median 33.6 Gy) with a boost to the posterior fossa (55 Gy). No patient received chemotherapy at primary treatment. Pattern of failure, overall survival (OS), disease free survival (DFS) and survival after recurrence (SAR) were analysed. Age, tumour location, desmoplasia in histology examination, extent of resection, shunt presence, performance and neurologic status were included in a univariate analysis in order to assess possible factors influencing overall survival. The disease stage was disregarded because of insufficient initial staging. Results. Actuarial 5- and 10- year OS rates were 55 p.c. and 44 p.c., respectively. Actuarial 5- and 10- year DFS rates were 44 p.c. and 31 p.c. respectively. In univariate analysis age was the only significant prognostic factor for OS. For patients less than 30 years of age 5-year OS rate was 40 p.c., for elders - 90 p.c., p = 0.004. A tendency to improve OS was observed with better performance and neurologic status, and location in the cerebellar hemisphere, whilst the presence of shunt and gross total resection worsened OS without statistical significance. Tumour recurred in 17 (63 p.c.) patietns. Ten relapses (59 p.c.) occurred within the first 2 ...


    392/2523

    Tytuł oryginału: Radiotherapy outcomes in laryngeal cancer - a retrospective study.
    Tytuł polski: Wyniki radioterapii chorych na raka krtani - analiza retrospektywna.
    Autorzy: Hliniak Andrzej, Michalski Wojciech, Szutkowski Zbigniew, Jarząbski Andrzej, Laskus Zofia, Frenkiel Zofia, Osmólski Antoni, Rolski Wojciech
    Źródło: Nowotwory 2002: 52 (2) s.111-117, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy jest analiza wyników radykalnej radioterapii chorych na raka krtani w zależności od typowych czynników klinicznych takich jak: wiek, płeć, stopień zaawansowania choroby, stopień histopatologicznego zróżnicowania, stopień sprawności chorego, lokalizacja nowotworu, poziom hemoglobiny we krwi oraz zbadanie znaczenia potencjalnych czynników rokujących takich jak: intensywność palenia papierosów oraz występowanie choroby wieńcowej i stanów pogruźliczych w płucach. Analizowano retrospektywnie informację o 372 chorych leczonych w latach 1989-1995 samodzielnie i radykalnie promieniami w Zakładzie Teleradioterapii II Centrum Onkologii - Instytutu w Warszawie. Charakterystyka materiału: 88 proc. mężczyzn, 12 proc. kobiet, wiek: 29-82 lat, zaawansowanie: T1-20 proc., T2-34 proc., T3 - 30 proc., T4 - 16 proc., przerzuty do węzłów chłonnych: 27 proc. Całkowitą odpowiedź na leczenie (CR) uzyskano w 71 proc. przypadków. Wyleczenia miejscowe po 2 latach wynoszą 52 proc. (T1-T2 - 64 proc., T3-T4 - 40 porc.). Wczesne reakcje : ból w przełykaniu, zlewne zapalenie błony śluzowej i złuszczanie wilgotne odnotowano odpowiednio w 69 proc., 48 proc. i 41 proc. przypadków. Ciężkie powikłania późne stwierdzono u 19 pacjentów. Stwierdzono istotny wpływ stopnia zaawansowania klinicznego T i N oraz stopnia sprawności na ryzyko zgonu. Pacjenci w późnym stopniu zaawansowania (T3 - T4) mieli dwukrotnie wyższe ryzyko zgonu od pacjentów we wczesnym stopniu zaawansowania (T1 - T2). Ryzyko ...

    Streszczenie angielskie: Study aim. To analyze the importance of pre-treatment factors (age, sex, T, N, histological differentiation, site, Hb level, performance status) and to investigate the influence of cigarette smoking and pulmonary and cardiac diseases on treatment oucomes in laryngeal cancer patients. Material and methods. From the year 1989 until May 1995 372 consecutive patietns with cancer of the larynx were radically irradiated at the 2nd Telradiotherapy Department of The Maria Skłodowska-Curie Memorial Cnacer Centre and Institute of Oncology in Warsaw (MSCMCC). Pt. characteristics - 88 p.c. men; 12 p.c. women, age: 29-82 years, stages: T1 - 20 p.c., T2 - 34 p.c., T3 - 30 p.c., T4 - 16 p.c., lymph node metastases: 27 p.c. Results. Complete response to treatment (CR) - 71 p.c. of cases. Loco-regional control after 2 years 52 p.c. (T1-T2 - 64 p.c., T3-T4 - 40 p.c.). Early reactions: pain on swallowing confluent mucositis and most skin reaction in 69 p.c., 48 p.c. and 41 p.c. of cases, respectively. Serious late complications - 19 patietns. In a majority of these cases several forms of serious damage were observed. Patietns with advanced disease (T3 - T4) present a two times higher death risk as compared to patienys in earlier stages of the disease (T1-T2). Patients with cervical node metastases also present a two times higher death risk as compared to NO cases. Patients with performance status 1 or more had a respectively three or four times hither death risk than patients with ...


    393/2523

    Tytuł oryginału: Clinical profile and outcome of patietns with cardiac myxomas treated surgically. A 20-yera experience with long-term follow-up.
    Tytuł polski: Przebieg kliniczny i wyniki leczenia chirurgicznego u chorych ze śluzakami serca - 20 lat doświadczeń.
    Autorzy: Jemielity Marek, Perek Bartłomiej, Katarzyński Sławomir, Misterski Marcin, Dyszkiewicz Wojciech
    Źródło: Nowotwory 2002: 52 (2) s.118-122, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp. Pierwotne nowotwory serca należą do rzadkości. Pośród nich łagodne śluzaki są najczęstszymi pierwotnymi guza serca. Celem pracy było przedstawienie charakterystyki klinicznej i ocena odległych wyników leczenia chorych operowanych z powodu śluzaków serca. Chorzy i metoda. Od 1981 r. do 2000 r. operaowano 21 chorych (12 kobiet i 9 mężczyzn), w wieku od 21 do 74 lat (średnio 43,9 ń 14,5 lat). Przed operacją chorych poddano badaniu fizykalnemu, wykonano badanie EKG, zdjęcie radiologiczne klatki piersiowej, echokardiografię (M + 2D) i koronografię (u chorych powyżej 40 lat). Wszystkich operowano ze sternotomii pośrodkowej w umiarkowanej hipotermii (26-28řC), z użyciem krążenia pozaustrojowego. Podczas ostatniej obserwacji odległej oceniano stan kliniczny i ponownie wykonano echokardiografię (M + 2D). Wyniki. Przed operacją u 19 chorych (90,5 proc.) stwierdzono objawy typowe dla zwężenia lewego ujścia żylnego. Sześciu spośród nich (28,6 proc.) znajdowało się W II klasie wydolności według Nowojorskiego Towarzystwa Kardiologicznego (NYKA), 8 chorych (38,1 proc.) w klasie III i 5 (23,8 proc.) w klasie IV. Epizody zatorowe przed operacją obserwowano u 6 chorych (28,6 proc.). Dziesięciu chorych (47,6 proc.) prezentowało niespecyficzne objawy ogólne, w tym przewlekłe gorączki i znaczną utratę masy ciała. Dwóch chorych (9,5 proc.) było bezobjawowych przed opracją. We wszystkich przypadkach ostateczne rozpoznanie stawiano na podstawie badania echokardiograficznego. Śluzaki ...

    Streszczenie angielskie: Introduction. Primary neoplasms of the heart are very rare, benign cardiac myxomas being the most common. The aim of this study was to present the clincial profile and long-term outcome of patietns (pts) who underwent surgical resection of cardiac myxoma. Material and methods. Between 1981 and 2000, 21 pts (12 female and 9 male), mean age 43.9 ń 14.5 years (range: 21-74 yrs) underwent surgery for cardiac myxoma. Before surgery we performed physical examination, ECG, chest X-ray, echocardiography (M + 2D) and coronary artery angiography (in patietns over 40 years of age). All pts were operated by median sternotomy in moderate hypotheramia (26-28řC) with the use of cardiopulmonary bypass. At the end of the follow clincial examination and echocardiography (M + 2D) were performed. Results. Before operation 19 pts (90.5 p.c.) presented with cardiac signs related to mitral orifice obstruction. Six of them (28.6 p.c.) were NYHA class II, 8 (38.1 p.c.) - class III and 5 (23.8 p.c.) - calss IV. Events of embolism occurred in 6 pts (28.6 p.c.). Ten pts (47.6 p.c.) had nonspecific systemic or constitutional symptoms, including permanent fever and significant weight loss. Two pts (9.5 p.c.) were asymptomatic, diagnosis being established accdentally. In all cases definite diagnosis was made by echocardiography. The myxomas were located in the left atrium in 18 pts (85.7 p.c.), in the right atrium in 2 pts (9.6 p.c.) and in the right ventricle in one pt (4.7 p.c.). One pt (4.7 ...


    394/2523

    Tytuł oryginału: 3- mercaptopyruvate sulfurtransferase and rhodanese activities in human myometrium and leiomyomas of the uterus.
    Tytuł polski: Aktywność transferazy siarkowej 3-merkaptopirogronianu i rodanazy w mięśniu i mięśniaku macicy ludzkiej.
    Autorzy: Frendo Julian, Wróbel Maria, Wąs Kazimierz
    Źródło: Nowotwory 2002: 52 (2) s.123-125, il., tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie polskie: Transferaza siarkowa 3-merkaptopirogronianu (EC 2.8.1.2) i rodanaza (transferaza siarkowa tiosiraczan: cyjanek, EC 2.8.1.1) uczestniczą w procesie desulfuracji L-cysteiny, prowadzącym do tworzenia związków zawierających metaboilcznie aktywną zredukowaną siarkę, tak zwaną siarkę suflanową, mającą wpływ na proliferację komórek nowotworowych. W przypadku niektórych tkanek nowotworowych obserwowano znacznie obniżoną aktywność transferazy siarkowej 3-merkaptopirogronianu i rodanazy,jak również śladową ilość siarki sulfanowej. Podjęto badania porównawcze aktywności obydwu enzymów w tkance mięśniaka ludzkiego oraz mięśnia macicy, z którego się rozwinął. Oznaczenia wykonywano natychmiast po otrzymaniu tkanek, uzyskanych w trakcie zabiegu chirurgicznego usuwania nowotworu. Niespodziewanie stwierdzono, że aktynwność obydwu badanych enzymów jest wyższa w mięśniaku, w porównaniu do tkanki niezmienionej nowotworowo, co można tłumaczyć tym, że jest to nowotwór łagodny.

    Streszczenie angielskie: Background. 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) and rhodanese (thiosulfate: cyanide sulfurtransferase, EC 2.8.1.1) participate in L-cysteine desulfuration - the main source of metabolically active sulfane sulfur atoms, which possibly influence the proliferation of malignant cells. It has been demonstrated that 3-mercaptopyruvate sulfurtransferase and rhodanese activity can decrease in some transplanted neoplsms. Aim. To examine tumour tissue of the human uterus and to investigate the myometrium from which the growth developed. Methods. The activity of 3-mercaptopyruvate sulfurtrnasferase and rhodanese was assayed in myometrium and leiomyoma samples immediately after hysterectomies. Results. The activities of two sulfurtransferases are higher in the leiomyoma than in the myometrium. Conclusion. An increase in the activity of both sulfurtransferases in leiomyomas of the uterus is surprising in light of present day understanding of sulfur compound metabolism in neoplasms, and may be due to the fact that leiomyoma is a benign neoplasm.


    395/2523

    Tytuł oryginału: The usefulness of magnetic resonance imaging (MRI) in cervical carcinoma assessment a preliminary report.
    Tytuł polski: Wartość diagnostyczna rezonansu magnetycznego (MR) w ocenie raka szyjki macicy - doniesienia wstępne.
    Autorzy: Tacikowska Małgorzata, Grzesiakowska Urszula, Tacikowski Tadeusz, Sobiczewski Piotr
    Źródło: Nowotwory 2002: 52 (2) s.126-129, bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Cel. Zadaniem diagnostyki obrazowej nie jest wykrywanie raka szyjki macicy, lecz ocena stopnia zaawansowania. Celem pracy było: 1)porównanie badania MR z wynikami histopatologicznymi uzyskanymi po operacji, w ocenie wymiarów raka szyjki macicy; 2) analiza czułości i specyficzności badania MR w ocenie naciekania przymacicza; 3) ustalenie czułości i specyficzności badania MR w ocenie naciekania pochwy i macicy; 4) ocena przydatności badania w wykrywaniu przerzutów do węzłów chłonnych. Materiał i metoda. Materiał stanowiły badania MR miednicy, wykonane aparatem 2T firmy Elscint, u 15 chorych na raka szyjki macicy. Wiek chorych od 37 do 73 lat. Wszystkie chore były operowane w okresie nie dłuższym niż 30 dni od badania MR. Podczas badania MR wykonywano następujące sekwencje: przed podaniem środka kontrastowego (Gd DTPA) SE T1 w projekcji poprzecznej, po podaniu gadolimu SE T1 w projekcjach: poprzecznej, czołowej i strzałkowej, FSE T2 w projekcjach: poprzecznej, czołowej i strzałkowej. Wyniki. W ocenie wymiarów raka szyjki macicy badanie MR odznacza się wysoką zgodnością (p = 0.9389) z wynikami pooperacyjnego badania histopatologicznego. W ocenie naciekania przymacicza czułość i specyficznośc badania MR wynoszą odpowiednio: 75 proc. i 100 proc. W ocenie naciekania pochwy i trzonu macicy czułość i specyficzność badania MR wynoszą odpowiednio: 100 proc. i 85 proc. oraz 100 proc.i 100 proc. Badanie MR jest mało czułą (67 proc.), lecz wysoce specyficzną (100 proc.) metodą ...

    Streszczenie angielskie: Aim. The aim of diagnostic is not so much the detection of cervical carcinoma, but the evaluation of its stage. In view of this the aim of this study included: 1) comparison of MR results with the results of histological examinations after operations with reference to the dimensions of cervical carcinoma; 2) assessment of the sensitivity and specificity of MRI in the evaluation of parametrium infiltration; 3) analysis of the sensitivity and specificity of MRI in the evaluation of infiltration of the vagina and uterus; 4) assessment of the usefulness of theis method in the detection of metastases to lymph nodes. Material and method. The material consisted of pelvic MRI, obtained with 2T Elscint unit in 15 patietns with cervical carcinoma, aged 37 to 73 years. All patietns underwent surgical treatment within 30 days after MR. During the MR examination the following sequences were performed: SE (spin echo) T1 (longitudinal relaxation time) in axial projection before administration of gadolinium (Gd-DTPA); SE T1 in axial, frontal and sagittal projections after contrast injection and FSE (fast spin echo) T2 (transversal relaxation time) in axial, frontal and sagittal projections. Results. 1) in the assessment of cervical carcinoma dimensions MRI results are highly concordant with the results of postoperative histological examination (p = 0.9389); 2) in the assessment of parametrium infiltration sensitivity and specificity of MRI are 75 p.c. and 10 p.c. respectively; 3) in ...


    396/2523

    Tytuł oryginału: Seventieth anniversary of the opening of the Radium Institute in Warsaw.
    Autorzy: Towpik Edward, Sobieszczak-Marciniak Małgorzata, Mould Richard F.
    Źródło: Nowotwory 2002: 52 (2) s.130-143, il.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa


    397/2523

    Tytuł oryginału: Application of high-performance size exclusion chromatography to the determination of erythropoietin in pharmaceutical preparations.
    Autorzy: Dudkiewicz-Wilczyńska Jadwiga, Snycerski Andrzej, Tautt Jadwiga
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.83-86, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: High performance size exclusion chromatography with fluorimetric detection for the determination of erythropoietin in pharmaceutical preparations has been developed. The applied chromatographic system has been enabled a quick estimation of the identity and contents of the studied compound. The method was validated and showed good validation data in terms of lineary, precision and repeatability. The validated method was successfully applied to the determination of erythropoietin content in commercially available preparations.


    398/2523

    Tytuł oryginału: Application of topological indexes for evaluation of the TLC separation of selected essential oil components.
    Autorzy: Pyka Alina, Bober Katarzyna, Gurak Danuta, Niestroj Anna
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.87-91, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The selected essential oil components (menthol, (+)borneol, geraniol, linalool, carvone, camphor, (IR)-(-)fenchone) were separated by adsorption thin-layer chromatography using benzene as mobile phase. Investigated terpenes were characterized by selected topological indexes based on the adjacency and distance matrix. From among all the topological indexes counted only Si(o) index (the sum of the distance between the oxygen atom and the remaining atoms in graph) as well as cluster Randić indexes (4lambdac, and 4 lambdacv) allow for estimation of the chromatograms obtained. With the fact mentioned above, there exists the possibikity of prediction of relative situation on a chromatogram of the terpens investigated. For the rest of topological indexes that possibility was not stated.


    399/2523

    Tytuł oryginału: Determination of the content of vitamin K, in complex vitamin preparations by the HPLC method.
    Autorzy: Kłaczkow Gabriela, Anuszewska Elżbieta L.
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.93-97, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the present study we tried to use HPLC method to determine the vitamin K1 content in complex vitamin preparation. The reverse phases technique was applied and measurements were made at the wavelenght 248 nm. On the base of statistical analysis we can note that conditions for HPLC method used in our work gave us precise and accuirate results.


    400/2523

    Tytuł oryginału: Pharmaceutical availability of betamethasone dipropionate and gentamicin sulfate from cream and ointment.
    Autorzy: Dyderski Stanisław, Grześkowiak Edmund, Szałek Edyta, Mrzygłód Agnieszka
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.99-103, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Kinetics of drug release from both compared preparations occuring as a cream and ointment, was in vitro studied. A reversed-phase HPLC method was developed for the determination of betamethasone dipropionate in lipophylic bases. Analyses were performed using a PLRP column with a mobile phase of methanol-acetonitrile-water and ultraviolet detection at lambda = 254 nm. The calibration curve was constructed for concentration 1.0 - 50.0 ćg/ml. The method is simple, accurate and precise. For the determination of gentamicin sulfate the FPIA method was used.


    401/2523

    Tytuł oryginału: Effect of microcrystalline chitosan on the solubility of ibuprofen.
    Autorzy: Bodek Kazimiera H.
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.105-108, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: It was found that MCCh may be used for the enhancement of the solubility and dissolution rates of drugs. The solubility of IBA in water increased significantly (about 10-fold) when MCCh was added. Differential scanning calorimetry (DSC), powder X-ray diffractometry, and IR spectroscopy were used to confirm that salt links between the drug and MCCh occurred.


    402/2523

    Tytuł oryginału: Investigation of hypoglycemic properties of rectal suppositories with chloropropamide.
    Autorzy: Kosior Anna
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.109-113, tab., bibliogr. 8 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Rectal suppositories with chlorpropamide and suppositories with chlorpropamide in the dispersion system with urea prepared. Witepsol H15 and H190 and a polyoxyethylenglycol mixture were used as bases. Rabbits were tested for blood-glucose level. The animals have been administered with prepared suppositories and commercial tablets. It was found the suppositories prepared on the basis Witepsol H15 with the dispersed chlorpropamide caused a much higher decrease of blood-glucose level than commercial tablets.


    403/2523

    Tytuł oryginału: Evaluation of adriamycin induced DNA damage and repair in human and animal cells.
    Autorzy: Chłopkiewicz Bożena
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.115-120, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • bydło
  • małpy
  • myszy

    Streszczenie angielskie: Adriamycin induced DNA damage and repair were investigated by the comet assay in four human cell lines (CRL2088, ME18, Lu106, WISH) and five animal cell lines (L929, Balb/3T3, CHO, MDBK, Vero). The results indicated the concentration-dependent induction of DNA strand breaks in all cell lines after adriamycin treatment. Simultaneously, wide differences in sensitivity of cell to the damaging action of adriamycin were observed. The most sensitive were two human cell lines derived from epithelial tissues, Lu106 and WISH. In these lines the breaks induced by adriamycin were not repaired within 6 h postincubation. In two other human cell lines, CRL2088 and ME18, only a small number of DNA breaks appeared after adriamycin exposure and these were very quickly repaired. Among the animal cell lines only the mouse cell line L929 was very sensitive to adriamycin, but most of the induced breaks were repaired within 6 h postincubation. The remaining animal cell lines were less sensitive to DNA damage by adriamycin and all except 3T3, completely repaired the breaks within 6 h postincubation.


    404/2523

    Tytuł oryginału: A new method for the synthesis of ranitidine.
    Autorzy: Lipnicka Urszula, Jasztold-Howorko Ryszard, Witkiewicz Krystyna, Machoń Zdzisław
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.121-125, il.,bibliogr. 36 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: An improved synthesis of the antiulcer drug Ranitidine from an oxazolidine derivative is reported.


    405/2523

    Tytuł oryginału: Pyrrole analogues of chloramphenicol. [P.] 3: Synthesis and antibacterial activity of DL-threo-1-(1-methylsul-fonylpyrrole-3-YL)-2-dichloroacetamidopropane-1,3-diol.
    Autorzy: Krajewska Dorota, Dąbrowska Marta, Jakoniuk Piotr, Różański Andrzej
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.127-132, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A seven-stage synthesis of a pyrrole analogue of chloramhenicol is described. The compound exhibits a significant antibacterial activity, over the 3 p.c. to 50 p.c. range of the chloramphenicol activity; over the 6 p.c. to 100 p.c. range of the thiamphenicol activity and florfenicol.


    406/2523

    Tytuł oryginału: Further flavonoids from the flowers of Prunus spinosa L.
    Autorzy: Olszewska Monika, Wolbiś Maria
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.133-137, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Further seven flavonoidis were isolated from the flowers of Prunus spinosa L.: quercetin 3-0-ŕ-L-arabinopyranoside, 3-0-ŕ-L-rhamnopyranoside, 3-0-á-D-xylo-pyranoside, and 3-0-á-D-glucopyranoside, kaempferol 3,7-di-0-ŕ-L-rhamnopyranoside, kaempferol and quercetin 3-0-(4"-á-D-glucopyranosyl)-ŕ-L-rhamnopyranosides. Four of them have been found for the first time in this plant. Structural elucidation was performed by means of chemical and spectral methods (UV, LSI MS, 1D and 2D NMR).


    407/2523

    Tytuł oryginału: Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae).
    Autorzy: Patora Jolanta, Klimek Barbara
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.139-143, il., bibliogr. 20 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Six flavonoids have been isolated from the leaves of lemon balm (Melissa officinalis L., Lamiaceae). Their structures were determined on the basis of spectral data (UV, IR, 1H NMR, 13C NMR and FAB MS) as luteolin, luteolin 7-0-á-D-glucopyranoside, apigenin 7-0-á-D-glucopyranoside, luteolin 7-0-á-D-glucuronopyranoside, luteolin 3'-0-á-D-glucuronopyranoside and luteolin 7-0-á-D-glucopyranoside-3'-0-á-D-glucuronopyranoside. The last three glycosides have been found in lemon balm for the first time and nuteolin 7-0-á-D-glucopyranoside-3'-0-á-D-glucuronopyranoside is a new compound found in plants.


    408/2523

    Tytuł oryginału: Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L.
    Autorzy: Smolarz Helena D.
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.145-148, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The flavonoid aglycones were studied in the herbst of the following taxons of the Polygonum L. genus: P. hydropiper l., P. bistorta L., P. aviculare L., P. persicaria L., P. lapathifolium ssp. tomentosum (Schrank) Dans, P. lapathifolium ssp. nodosum (Pers.) Dans, P. amphibium L., P. mite Schrank, P. convolvus L. (Bilderdykia convolvuls L.) by means of the RP-HPLC method. The content of taxifolin, qurcetin, guercetin-3-methyl erher, kaemferol, myritcetin, luteolin, isorhamnetin and rhamnetin were determined.


    409/2523

    Tytuł oryginału: Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).
    Autorzy: Tristani-Firouzi Martin, Jensen Judy L., Donaldson Matthew R., Sansone Valeria, Meola Giovanni, Hahn Angelika, Bendahhou Said, Kwieciński Hubert, Fidziańska Anna, Plaster Nikki, Fu Ying-Hui, Ptacek Louis J., Tawil Rabi
    Źródło: J. Clin. Invest. 2002: 110 (3) s.381-388, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 310,487

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Andersen syndrome (AS) is a rare, inherited disorder characterized by periodic paralysis, long QT (LQT) with ventricular arrhythmias, and skeletal developmental abnormalitise. We recently established that AS is caused by mutations in KCNJ2, which encodes the inward rectifier K+ channel Kir2.1. In this report, we characterized the functional consequences of three novel and seven previously described KCNJ2 mutations using a two-microelectrode voltage-clamp technique and correlated the findings with the clinical phenotype. All mutations resulted in loss of function and dominant-negative suppression of Kir2.1 channel function. In mutation carriers, the frequency of periodick paralysis was 64 p.c. and dysmorphic features 78 p.c. LQT was the primary cardiac manifestation, present in 71 p.c. of KCNJ2 mutation carriers, with ventricular arrhythmias present in 64 p.c. While arrhythmias were common, none of our subjects suffered sudden cardiac death. To gain insight into the mechanismof arrhythmia susceptibility, we simulated the effect of reducdd Kir2.1 using a ventricular myocyte model. A reduction in Kir2.1 prolonged the termkinal phase of the cardiac action potential, and n the setting of reduced extracellular K+, nduced Na+/Ca2+ exchanger-dependent delayed afterdepolarizations and spontaneous arrhythmias. These findings suggest that the substrate for arrhythmia susceptibility in AS is distinct from the other forms of inherited LQT syndrome.


    410/2523

    Tytuł oryginału: 1- methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats.
    Autorzy: Luchowski Piotr, Luchowska Elżbieta, Turski Waldemar A., Urbańska Ewa M.
    Źródło: Neurosci. Lett. 2002: 330 (1) s.49-52, il., bibliogr. 22 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The aim of the present study was to evaluate the effect of mitochondrial inhibitors, 1-methyl-4-phenylpyridinium (MPP+) and 3-nitropropionic acid (3-NPA), on the brain production of endogenous glutamate antagonist, kynurenic acid (KYNA). MPP+ and 3-NPA dose-dependently impaired the synthesis of KYNA in rat cortical slices. Enzymatic studies revealed the MPP+ inhibits in a concentration-dependent manner the activity of kynurenine aminotransferase II (KAT II), but not the activity of kynurenine aminotransferase I (KAT I). 3-NPA impaired the activity of both enzymes, KAT I and KAT II. Thus, MPP+ - and 3-NPA-evoked neurotoxicity may be at least partially associated with the depletion of KYNA.


    411/2523

    Tytuł oryginału: Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study.
    Autorzy: Seniuk W., Mularek-Kubzdela T[atiana], Grygier M[arek], Grajek S., Cieśliński A[ndrzej]
    Źródło: J. Intern. Med. 2002: 252 (4) s.368-376, il., bibliogr. 33 poz.
    Sygnatura GBL: 300,763

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We present three patients with variant angina pectoris and episodes of cardiac arrest. All of them had typical clinical symptoms, ST-segment changes in electrocardiogram, and coronary artery spasm confirmed by arteriography. They were treated with high doses of calcium antagonists and nitrates. An automatic cardioverter-defibrillator was implanted in the patient who developed ventricular fibrillation despite therapy with calcium antagonists. In another patient a DDD pacemaker was implanted becasue of high-degree atrioventricular blok.


    412/2523

    Tytuł oryginału: Porihvnjalnijj analihz sistem opodatkuvannja zarobihtnoji płati pracihvnikihv aptek v Ukrajinih hi Polshhih.
    Tytuł angielski: The comparative analysis of systems of the taxation of wages of pharmacies workers i Ukraine and Poland.
    Autorzy: Tereshhuk S. Ih., Moska Dionizy, Moska Dariusz, Tereshhuk T. O., Labus O.
    Źródło: Farm. Zh. 2002 (3) s.27-32, il., tab., bibliogr. 9 poz., sum., rez.
    Sygnatura GBL: 304,380

    Hasła klasyfikacyjne GBL:
  • ekonomika
  • farmacja

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The compareative analysis of taxacion systems of private individuals and ownershipers's wages in Ukraine and Poland has been carried out. It is established, that more flexible and transparent system of the taxes is used in Poland, according to which the base for the taxation decreases on living expenses of the citizens.


    413/2523

    Tytuł oryginału: Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice.
    Autorzy: Kłodzińska Aleksandra, Bijak Maria, Tokarski Krzysztof, Pilc Andrzej
    Źródło: Pharmacol. Biochem. Behav. 2002: 73 (2) s.327-332, il., bibliogr. s. 331-332
    Sygnatura GBL: 312,498

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: It has been suggested that metabotropic glutamate (mGlu) receptor agonists selective for Group II mGlu receptors may have antipsychotic action. Therefore, we studied whether the effects, which could be related to psychotomimetic action of hallucinogenic drugs, are inhibited by Group II mGlu receptor agonists. The selective mGlu2/3 agonist LY354740 and LY379268 inhibited (ń)1-(2,5-dimethoxy-4-iodophenyl)-2-aminoproprane (DOI)-induced head twitches in mice in a dose-dependent manner. Furthermore, LY379268 suppressed an increase in the frequency of sponataneous excitatory synaptic potentials induced by bath-applied DOI in layer V pyramidal cells recorded in the murine medial frontal cortex. The data indicate that Group II mGlu receptor agonist may counteract the effects of hallucinogenic drugs.


    414/2523

    Tytuł oryginału: Sex hormone-binding globulin polymorphisms in familial and sporadic breast cancer.
    Autorzy: F”rsti Asta, Jin Quinren, Grzybowska Ewa, S”derberg Magnus, Zientek Helena, Siemińska Marzena, Rozgozińska-Szczepka Jadwiga, Chmielik Ewa, Utracka-Hutka Beata, Hemminki Kari
    Źródło: Carcinogenesis 2002: 23 (8) s.1315-1320, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 312,779

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Ovarian steroids are one of the strongest risk factors for breast cancer. Sex hormone-binding globulin (SHBG) binds and transports sex steroids in the blood, regulating their bioavailable fraction and access to target cells. It can also inhibit the estradiol-induced proliferation of breast cancer cells through its membrane receptor. Three coding-region polymorphisms, which oead to an amino acid change, have been reported. We studied the influence of these three polymorphisms on breast cancer risk in three different populations: polish familial breast cancer cases, 27 p.c. of them carrying a BRCA1/BRCA2 mutation, Nordic familial and sporadic breast cancer cases. The reported G to A polymorphism in exon 1 was not found in the 423 analyzed samples. Instead, we found a C to T transition causing an arg to cys amino acid change within the same codon in one polish breast cancer patient and her daughter. Both of them were heterozygotes for the exon 8 to A polymorphism as well. They were diagnosed for bilateral breast cancer and carried a BRCA1 mutation (5382insC). Analysis of the tumor samples showed that they had lost the wild-type allele both at exons 1 and 8 of the SHBG gene. Analysis of the other Polish samples showed no correlation of the exon 8 polymorphism to breast cancer, bilateral breast cancer, BRCA1/BRCA2 mutations or age at diagnosis. No association of the exon 8 polymorphism with breast cancer in the Nordic familial or sporadic cases was found. The C to T polymorphism located in exon 4 was rare in all the studied populations (overal allele frequency 0.011)...


    415/2523

    Tytuł oryginału: Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk.
    Autorzy: Benhamou Simone, Lee Won Jin, Alexandrie Anna-Karin, Boffetta Paolo, Bouchardy Christine, Butkiewicz Dorota, Brockm”ller Jurgen, Clapper Margie L., Daly Ann, Dolzan Vita, Ford Jean, Gaspari Laura, Haugen Aage, Hirvonen Ari, Husgafvel-Pursiainen Kirsti, Ingelman-Sundberg Magnus, Kalina Ivan, Kihara Masahiro, Kremers Pierre, Le Marchand Loic, London Stephanie J., Nazar-Stewart Valle, Onon-Kihara Masako, Rannug Agneta, Romkes Marjorie, Ryberg David, Seidegard Janeric, Shields Peter, Strange Richard C., Stcker Isabelle, To-Figueras Jordi, Brennan Paul, Taioli Emanuela
    Źródło: Carcinogenesis 2002: 23 (8) s.1343-1350, il., tab., bibliogr. 54 poz.
    Sygnatura GBL: 312,779

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detopxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied in this context; two recent meta-analyses of case-control studies suggested an association between GSTM1 deletion and lung cancer. At least 15 studies have been published after these overviews. We undertook a new meta-analysis to summarize the results of 43 published case-control studies including 18000 individuals. A slight excess of risk of lung cancer for individuals with the GSTM1 null genotype was found (odds ratio (OR) = 1.17, 95 p.c. confidence interval (CI) 1.07 - 1.27). No evidence of publication bias was found (P = 0.4), however, it is not easy to estimate the extent of such bias and we cannot rule out some degree of publications bias in our rsults. A pooled analysis of the original dsata of about 9500 subjects involved in 21 case-control studies from the international Collaborative Study on genetic Dusceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of gsTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power. Analyses revealed no evidence of increased risk of lung cancer among carriers of the GSTM1 null genotype (age-, gender- and center-adjusted OR = 1.08, 95 p.c. CI 0.98 - 1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption.


    416/2523

    Tytuł oryginału: Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells.
    Autorzy: Baj-Krzyworzeka Monika, Majka Marcin, Pratico Domenico, Ratajczak Janina, Vilaire Gaston, Kijowski Jacek, Reca Ryan, Janowska-Wieczorek Anna, Ratajczak Mariusz Z.
    Źródło: Exp. Hematol. 2002: 30 (5) s.450-459, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 305,749

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: objective. peripheral blood plateled-derived microparticles (PMPs) circulate in blood and may interact directly with target cells affecting their various biological functions. methods. To investigate the effect of human PMPs on hematopoiesis, we first phenotyped them for expression of various surface molecules and subsequently studied various biological responses of normal stem/progenitor (CD34+) and more differentiated precursor cells as well as several leukemic cell lines to PMPs. Results. We found that, in addition to platelet-endothelium attachment receptors (CD41, CD61 and CD62), PMPs express G-protein-coupled seven transmembrane-span receptors such as CXCR4 and PAR-1; cytokine receptors including TNF-RI, TNF-RII, and CD95; and ligands such as CD40L and PF-4. Moreover, we found that several of these receptors could be transferred by PMPs to the membranes of normal as well as malignant cells and observed that PMPs: 1) chemoattract these cells, 2) increase their adhesion, proliferation, and survival, and 3) activate in these cells various intracellular signaling cascades including MAPK p42/44, PI-3K-AKT, and STAT proteins. The biological effects of PMPs were only partly reduced by heat inactivation or trypsin digest, indicating that, in addition to the protein components of PMPs, lipid components are also responsible for their biological activity. conclusion. We conclude that PMPs modulate biological functions of hematopoietic cells and postulate that they play an important but as yet not fully understood role in intracellular cross-talk in hematopoiesis...


    417/2523

    Tytuł oryginału: The effect of verapamil on the antioxidant defence system in diabetic kidney.
    Autorzy: Kędziora-Kornatowska K., Szram S., Kornatowski T., Szadujkis-Szadurski L., Kędziora J., Bartosz G.
    Źródło: Clin. Chim. Acta 2002: 322 (1/2) s.105-112, tab., bibliogr. 44 poz.
    Sygnatura GBL: 303,881

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Bacground: The aim of the study was to examine the effect of verapamil (VP) on lipid peroxidation and activities of key antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px); as well as on glomerular basement membrane (GBM) thickness in streptozotocin-induced diabetic kidney in rats. Methods: Wistar male rats were divided into three groups, 12 rats each: the control (C), diabetic rats (DR), and DR receiving VP, 7 mg/kg body weight in drinking water (DR + VP). Blood glucose (BG) and HbA1c levels, 24-h urinary albumin excretion (UAE) and body weight (BW) were measured every week (0-12 weeks). After 6 and 12 weeks, the animals were sacrificed and malondialdehyde (MDA) content activatives of SOD, CAT and GSH-Px were determined in the kidney homogenate supernatans. Electron micrographs of the glomeruli were scanned and porhphometric investigations were performed by means of a computer image analysis system to compare the glomerular basement basal membrane (GBM) thickness. results: The levels of BG, HbA1c and UAE in DR were significantly higher than in the C group. A progressive increase in the MDA level and a decrease in the SOD, CAT and GSH-Px activaties in the kidney of DR were observed after 6 and 12 weeks. VP administration did not affect BW changes, BG and HbA1 levels in DR. VP decreased lipid peroxidation and augmented the activities of antioxidant enzymes studied in the kidneys of DR as well as decreased kidney weight, GBM thickness and albuminuria in DR. Conclusions: These results confirm the role of oxidative stress in the development of diabetic nephropathy and point to the possible antioxidative mechanism of the nephroprotective action of VP.


    418/2523

    Tytuł oryginału: Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study.
    Autorzy: Vergnaud P., Lunt M., Scheidt-Nave C., Poor G., Gennari C., Hoszowski K., Lopez Vaz A., Reid D. M., Benevolenskaya L., Grazio S., Weber K., Miazgowski T., Stepan J. J., Masaryk P., Galan F., Bruges Armas J., Lorenc R., Havelka S., Perez Cano R., Seibel M., Armbrecht G., Kaptoge S., O'Neill T. W., Silman A. J., Felsenberg D., Reeve J., Delmas P. D.
    Źródło: Clin. Chim. Acta 2002: 322 (1/2) s.121-132, tab., bibliogr. 49 poz.
    Sygnatura GBL: 303,881

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Bacground: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6 - 12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analysis measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphatase and albumin, together with the collagen cross-links degradation products serum CTS and urine CTX. Most subjects also had bone density neasured by DXA. Results: Cases who had recent fractures did not differ in marlker levels from cases who had their had last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6 p.c. lower in recent peripheral cases compared to unfractured controls (p 0.05) and this was independent of BMD. Conclusion: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover.


    419/2523

    Tytuł oryginału: Magnetic resonance imaging in gynecology - state of the art.
    Autorzy: Walecki J., Ceran A., Tarasów E., Panek G.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.111-119, il., bibliogr. 48 poz. - Sympozjum pt. Rozwój metod obrazowania diagnostycznego w położnictwie i ginekologii. Białowieża 11-12.05. 2002
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Dynamic development of MRI and MRS diagnostic capabilities resulted in more frequent application in obstetrics and gynecology; few years back this field was dominated by US. Main advantages of MR include much higher than any other modality spatial and contrast resolution, ability to characterise various tissues and analyse their chemical content. In our paper we would like to share our experience in clinical diagnosis of most common pathologies such as: cervical carcinoma, endometrial caarcinoma, ovarian and vaginal tumors. Techniques provided by MR are specxially useful in gynecological oncology. The greatest challenge which MR faces is staging of neoplasmatic growth and monitoring of treatment. Many additional techniques such as various kinds of multiplanar reconstructions, dynamic examinations, metabolite analysis in MRS greatly increase diagnostic efficiency of this modality.


    420/2523

    Tytuł oryginału: Tocopherol treatment during chemotherapy in ovarian cancer patients.
    Autorzy: Popiela A., Gabryś M., Pańszczyk M., Szewczuk A., Baranowski W.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.121-124, tab., bibliogr. 11 poz. - Sympozjum pt. Nauki przyrodnicze w ginekologii Puławy 31.05-01.06. 2001
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • ginekologia i położnictwo
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Tocopherol reduces free radicals damage to genomic DNA and regulates cellular metabolism through lowering protein kinase C activity. Tocopherol induces proliferation of the immune system cells through its influence on transcriptional factors. Lack of tocopherol causes dysfunction of cellular immune systems, especially lymphocyte T by destabilisation of cellular membranes. Investigated group consisted of 60 patients with ovarian cancer. Patients received 1000 units of tocopherol per day during postoperative chemotherapy. Tocopherol therapy lowered, although not statistically significantly, morbidity rate, frequency of nausea and vomiting and reduced the intensity of stomatitis, without any influence on total remission number.


    421/2523

    Tytuł oryginału: Collagen content in the anterior layer of the rectus sheath in postmenopausal women.
    Autorzy: Bogusiewicz M., Surowski S., Rzeźniczuk K, Adamiak A., Rechberger T.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.125-128, il., bibliogr. 18 poz. - Sympozjum pt. Nauki przyrodnicze w ginekologii Puławy 31.05-01.06. 2001
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Several studies revealed that postmenopausal decrease in skin thickness and elasticity, uterine prolapse as well as stress urinary incontinence are, at least in part, results of impaired collagen turnover. This study aimed at the evaluation of collagen content in the rectus sheath of premenopausal and postmenopausal women. Samples of the anterior layer of the rectus sheath were taken from 16 premenopausal and 7 postmenopausal women aged 31-51 years and 51-75 years, respectively, undergoing surgery due to benign diseases of the uterus or gall bladder. Collagen was extracted with acetic acid and subsequently with pepsin. The concentartion of collagen (all types) was measured using Sicrol Collagen Assay (Biocolor Ltd., Belfast, N. Irland). Significantly less collagen was extraced from the rectus sheath derived from postmenopausal as compared to premenopausal women (11.0 ń 5.5 (g/gram of wet tissue versus 21.5 ń 10.4 (g/gramof wet tissue; p=0.0033). Moreover, a negative correlation between collagen content and age of the subjects was observed (r = -0.47; p = 0.026). However, when the analysis was carried out separately for each group of women an association between the decrease in collagen content and aage was observed only in women after the menopause. Results of the study indicate that the content ofcollagen in the rectus sheath declines afetr the menopause. This effect seems to be dependant on hormonal changes related to menopause rather than on the process of ageing. The decrease in collagen content may cause faulty wound healing as well as predispose to abdominal hernias.


    422/2523

    Tytuł oryginału: Influence of LHRH agonistic analog, Decapeptyl, on the balance between proliferation and apoptosis in MCF-7 breast adenocarcinoma cells culture.
    Autorzy: Świątecka J., Dzięcioł J., Wołczyński S.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.129-135, tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Breast cancer cell line cultures provide an experimental model in which the action of a variety of mitogens and proapoptotic factors can be studied in vitro. Expression of LHRH and its receptor has been demonstarted in human breast adenocarcinoma, MCF-7 cell line, ER-positive. Antiproliferative effect of LHRH-analogs on breast cancer cells has been revealed. The aim of the present study was to examine the effect of different concentrations (10(-6) and 10(-7) g/ml) and time of exposition (24 hr, 48 hr and 72 hr) of Decapeptyl, an agonistic analog of LHRH, on the expression of wild and mutant p553 and bcl-2 gene products as well as on the proliferative activity (expressed as [3H] thymidine incorporation an dProliferating Cell Nuclear Antigen-PCNA and Mitotic Proteins-MPM2 antigens involvement) in MCF-7. Besides we compared the effects of Decapeptyl with the influence of Tamoxifen alone (10 ćM) and Tamoxifen along with Decapeptyl (10 ćM, 10(-6)g/ml respectively). Decapeptyl, independently of the used dose and time of exposition, did not alterradioactivity detected in studied cells in comparison with the control group. Furthermore, label found after 24 hours of exposition was comaprably high as after Estardiol treatment. Thymidine incorporation after Decapeptyl was consistently higher than afetr Tamoxifen and Tamoxifen/Decapeptyl together. Decapeptyl, in dose and time independent manner, do not change the number of PCNA-immunopositive cells, and only at higher concentration [10(-6) g/ml] decreased immunodetection of MPM2...


    423/2523

    Tytuł oryginału: Treatment of severe hirsutism with gonadotropin-releasing hormone analogues in women with polycystic ovary syndrome and idiopathic hirsutism and its influence on hormonal androgenisation indices.
    Autorzy: Kamiński K[azimierz], Łagan J., Cholewa D.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.137-146, il., tab., bibliogr. 25 poz. - Sympozjum pt. Aktualne problemy perinatologii i ginekologii Zabrze - Szczyrk 03-06.04. 2002
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Objective: To compare the therapeutic effect of treatment using either a gonadotropin releasing hormone analogue or an analogue with addition of ethinyl estradiol and cyproterone acetate in women with severe hirsutism with polycystic ovary syndrome and idiopathic hirsutism. Study design: Prospective clinical study. Forty-four hirsute women: 22 with polycystic ovary syndrome and 22 with idiopathic hirsutism were the subject of the study. Each group was divided and received two different treatment schemes. Sixteen women served as controls and received no treatment. After Ferriman-Gallwey scores were obtained, serum levels of testosterone, free testosterone, androsterone, dehyrdroepiandosterone sulfate, luteinizing hormone, insulin, and sex hormone binding globulin were determined. The free androgen index was calculated. Results: Both treatment schemes, using a gonadotropin releasing hormone analogue, and using an analogue with addition of ethinyl estradiol and cyproterone induced significantly the reduction of the free androgen index, and the increase of the sex hormone binding globulin serum levels. Those effects were more distinct in patients who received the analogue alone treatment. The biochemical changes presented in our study were accompanied by significantly decreased mean Ferriman-Gallwey score in the investigated women. Conclusionn(s): We conclude that in the cases with severe hirsutism, the more advantageous treatment is the application of combined therapy using a gonadotropin releasing hormone analogue and a pill containing ethinyl estradiol and cyproterone acetate as compared to the use of gonadotropin releasing hormone analogue alone.


    424/2523

    Tytuł oryginału: Association between bacterial vaginosis and cervicovaginal flora during pregnancy and threatened preterm labor.
    Autorzy: Wasiela M[ałgorzata], Hanke W., Kalinka J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.147-152, il., tab., bibliogr. 39 poz. - Sympozjum pt. Aktualne problemy perinatologii i ginekologii Zabrze - Szczyrk 03-06.04. 2002
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Bacterial vaginosis (BV) in pregnancy may complicate its course and harm the fetus or newborn after vertical transmission. The main aim of this study was to assess an association between bacterial vaginosis and bacterial vaginosis associated flora at early pregancy and threatened preterm labor (TPL). The study population comprised 179 pregnant women attending 10 randomly chosen Outpatients Maternity Units at Ist trimester. Cervicovaginal samples were obtained at 8-16 weeks of gestation. On the basis on Spiegel's criteria Gram-stained vaginal smears were examined for BV and bacterial vaginosis associated flora were sought by culture. In 23 (12.8 p.c.) cases, TPL was diagnosed during pregnancy. Bacterial vaginoses were more frequently diagnosed among women with TPL as compared to women with no symptoms of TPL (39.1 p.c. vs. 26 p.c.). BV increased the risk of TPL (OR=2.14). Women with bacterial vaginosis and TPL were more likely to be culture-positive for bacterial vaginosis associated flora like: M.hominis, U.urealyticum, G.vaginalis, Prevotella spp. Mobiluncus spp. and Bacteroides spp. Bacterial vaginosis at early pregnancy is associated with an increased risk of threatened risk of threatened preterm labor. Detailed microbiological monitoring of all pregnant women at early pregnancy should be introduced.


    425/2523

    Tytuł oryginału: The effect of oxidized lipoproteins (o-LDL) activity in pregnancies complicated by preeclampsia - role of o-LDL antibodies.
    Autorzy: Pawłowicz P[aweł], Stetkiewicz T., Wilczyński J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.153-158, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The aim of the study is to explain the influence of plasma oxidized lipoproteins on placenta function in pregnancies complicated by preeclampsia and in consequence, on fetal intrauterine asphyxia. Patients and methods: We studied 227 pregnant women between 32th and 40th week of gestation. Study group consisted of 159 pregnant women with preeclampsia. Control group included 118 healthy pregnant women. The level of oxidative stress was estimeted by circulating antibodies anti-O-LDL (oLAB) mesurement in pregnant women plasma. Antibodies anti-O-LDL (oLAB) was measured in plasma using immunoenzymatic method detecting autoantibodies IgG against oxidized plasmatic low density lipoproteins (LDL). Fetal well-being evaluation was based on computer analysis of CTG record (Oxford) and on blood flows measurements in umbilical and middle cerebral arteries of fetus. Results: The values of oLAB levels were higher for the study group than for the control group. Conclusions: In pregnancies complicated by preeclampsia, oxidative stress increase was noted, that index is elevated anti oLDL antibodies (oLAB) concentration.


    426/2523

    Tytuł oryginału: The influence of the combined, continuous hormone replacement thrapy on the autonomic regulation of gastric myoelectrical activity and heart rate variability.
    Autorzy: Banach T., Milewicz T., Krzysiek J., Laskiewicz J., Thor P[iotr] J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.159-167, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • ginekologia i położnictwo
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Objectives: Presence of dyspepsia symptoms in postmenopausal women during hormonal replacement therapy (HRT) has been often reported by clinicians. It suggests disturbances of motility of upper gastrointestinal tract. Aim: Aim of the study was to evaluate whether the continuous combined HRT (ccHRT) affects the gastric myoelectrical activity. Method: 20 healthy postmenopausal women aged 56 ń 5.5 years, 7 ń 5.4 years after the last menstruaction, were divided into two equal groups: women receiving ccHRT (serum levels of estradiol - 113.3 ń 87.1 ng/l and FSH - 48.1 ń 16.6 IU/l) and a control group (serum levels of estradiol - 23.1 ń 14.8 ng/l and FSH - 73.1 ń 24.3 IU/l). The ccHRT group have received transdermally 17 á-estradiol (Oesclim 50, Fournier) and daily 5 mg of dydrogesterone (Duphaston, Solvay Pharma) orally, for recent 1.4 ń 0.6 years. Thirty min. of electrogastrography (EGG Digitrapper - Synectics, Sweden) and 5 min. of heart rate variability (HRV 2000 - Proster, Poland) recordings before and after 6 min. of SF (sham feeding: 3 chewing gums, 2 min. per each) were carried out in both groups Standard parameters of EGG and HRV were estimated. Statistical analysis: Shapiro-Wilk test, Mann-Whitney u-test, p 0.05 was considered as significant. Results: Mean normogastria with similar period dominant frequencies (PDF) dominanted in both groups before SF (83.9 ń 15.1 p.c. vs. 80.6 ń 27.3 p.c.; p 0.05). SF did not alter frequency but doubled amplitude of basic electrical rhythm (BER) in control group. In HRT patients, normogastria decreased by about 30 p.c. (p 0.05)...


    427/2523

    Tytuł oryginału: Pretreatment levels of antigens CA 125 and CYFRA 21-1 in patients with endometrial cancer.
    Autorzy: Pierzyński P[iotr], Mazurek A., Kuć P., Krętowska M., Mazurek E., Laudański T.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (3) s.169-174, tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Cancer antigens CA 125 and CYFRA 21-1 are relatively well studied in certain malignancies such as ovarian and lung cancer, they may also bring some additional information in endometrial cancer. Clinical material comprised of 55 postmenopausal patients with endometrial cancer, serum samples were taken 48 hour before the surgery. CA 125 was assessed immunoenzymatically (reference level 35 U/ml), IRMA (immunoradiometric assay method) was applied for CYFRA 21-1 determinations (reference level 3.2 ng/ml). Cyfra 21-1 levels were elevated in 29.1 p.c. of cases. This marker was positive in 22.1 p.c. of patients of I st FIGO stage and in 56.3 p.c. and 50 p.c. of cases of II and III FIGO stage, respectively. Fisher's exact test and Kruskal-Wallis test confirmed significant differences in CYFRA 21-1 results between groups of FIGO stage of disease. The CA 125 positive cases were of 38.2 p.c. of group studied, this marker was positive in 51.5 p.c. of cases of FIGO I stage of disease, and reached 78.7 p.c. and 100 p.c. cases for stages II and III, respectively. Kruskal-Wallis test confirmed the significance of relationship between CA 125 levels and FIGO stage of disease (p.=0.0025). Our results show that CYFRA 21-1 and CA 125 might be an additional parameter in clinical evaluation of patients with endometrial cancer. Further observation would reveal th einfluence of the CA 125/CYFRA 21-1 positivity on patients' survival, the study concerning that is in the progress.


    428/2523

    Tytuł oryginału: Persistent oxidative stress in colorectal carcinoma patients.
    Autorzy: Gackowski Daniel, Banaszkiewicz Zbigniew, Rozalski Rafał, Jawień Arkadiusz, Oliński Ryszard
    Źródło: Int. J. Cancer 2002: 101 (4) s.395-397, tab., bibliogr. 34 poz.
    Sygnatura GBL: 305,029

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We examine whether the level of 8-oxo-2'-deoxyguanosine (8-oxodGuo) in lymphocytes DNA is higher in colon cancer when compared to the control group. Factors that may influence oxidative stress such as antioxidant vitamins and uric acid were also determined. Blood samples were obtained from a control group of 55 healthy persons and 43 colon cancers. 8-OxodGuo level and the vitamins concentraction were measured by high-performance liquid chromatography. The levels of 8-oxodGuo were significantly higher whereas the concentractions of the vitamins and uric acid were significantly lower in colon cancer patients than in control group. Therefore, the decreased concentration of antioxidant vitamins together with lower amount of uric acid may be responsible for the formation of pro-oxidative environment in blood of colorectal carcinoma patients.


    429/2523

    Tytuł oryginału: Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems.
    Autorzy: Szyndler Janusz, Rok Paulina, Maciejak Piotr, Walkowiak Jerzy, Członkowska Agnieszka I., Sienkiewicz-Jarosz Halina, Wisłowska Aleksandra, Zienowicz Małgorzata, Lehner Małgorzata, Bidziński Andrzej, Kostowski Wojciech, Płaźnik Adam
    Źródło: Pharmacol. Biochem. Behav. 2002: 73 (4) s.851-861, il., tab., bibliogr. [23] poz.
    Sygnatura GBL: 312,498

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The influence of pentylenetetrazol (PTZ)-induced kindling of seizures on the rat emotional behaviour, the brain monoamine turnover rate measured in vitro, and correlation between behavioral and biochemical parameters, were examined in rats. The repeated administration of PTZ (35 mg/kg, ip) evoked kindled seizures in rats (Stage 4 or 5 of clonic - tonic convulsions - maximum). PTZ kindling caused selective changes in the rat emotional behavior, present in some models of anxiety only (a decreased freezing time in the conditioned freezing test and a decreased spontaneous and aversively conditioned ultrasonic vocalization). Simultaneously, PTZ kindling decreased the concentration of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the prefrontal cortex, decreased the DA (HVA/DA ratio) turnover rate in the striatum, and inhibited the serotonin (5-HT) metabolism (5-HIAA/5-HT ratio) in the hippocampus and the prefrontal cortex. Correlations between dopamine (DA) or 5-HT regional metabolic rats in brain structures and animal behavior were either abolished or reversed in PTZ-kindled animals. It is concluded that both DA and 5-HT systems contribute to the emotional effects of PTZ-induced kindling of sizures. The hypothesis is put forward that PTZ kindling-induced inhibition of the serotonergic innervation may lead to the compensatory increase in 5-HT1A receptors in the dentate gyrus of the hippocampus, thus evoking the anxiolytic-like changes in animal behavior.


    430/2523

    Tytuł oryginału: Temperature-sensitive ovarian carcinoma cell line (OvBH-1).
    Autorzy: Bar Julia K., Harłozińska Antonina, Kartarius Sabine, Montenarh Mathias, Wyrodek Ewa, Parkitna Rodriquez Jan M., Kochman Marian, Ożyhar Andrzej
    Źródło: Jpn. J. Cancer Res. 2002: 93 (9) s.976-985, il., bibliogr. 65 poz.
    Sygnatura GBL: 301,570

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: OvBH-1 cells from a patient with ovarian clear cell carcinoma were established and their biochemical status was analyzed. Cells grown at 37řC exhibited normal cell cycle distribution, whereas the cells shifted to 31řC were arrested in the G2/M phase of the cell cycle. Immunochemical analysis using anti-p53 antibodies (DO-1, PAb240, PAb421, and PAb1620) revealed that only the DO-1 antibody reacted with p53 with a high and similar percentage at both temperatures. PAb240 reacted with a low percentage of cells at 37řC and no reaction was observed at 31řC. PAb421 antibody stained a significantly lower percentage of cells at 37řC than at 31řC. Cells were not stained with PAb1620 antibody and were negative for antibodies against p21**WAF1 and MDM2 proteins independently of the temperature. Sequencing of all coding exons of the p53 gene demonstrated only a neutral genetic polymorphism, i.e. a G-to-A substitution (GAG to GAA) at nucleotide position 13 432. Thus, the observed temperature sensitivity of OvBH-1 cells cannot be ascribed to a p53 primary structure mutation. Based upon immunochemical analyses, we consider, however, that p53 in nuclei of OvBH-1 cells is in a highly unstable conformation. Furthermore, the N-terminal portion of the p53 protein at Ser20 has not been modified, and Lys373 and/or Ser 378 of the C-terminus is acetylated and/or phosphorylated. The nuclear location signal of p53 is preserved. Induction of MDM2 protein is uncoupled from the cell regulatory machinery and the induction of p21**WAF1 by p53 is impaired in OvBH-1 cells.


    431/2523

    Tytuł oryginału: Związek między aktywnością hydrolaz grzybów wyizolowanych z pochwy kobiet ciężarnych i wybranymi objawami klinicznymi.
    Tytuł angielski: Relationship between activity of hydrolases in fungi isolated from vagina of pregnant women and selected symptoms.
    Autorzy: Nowakowska Dorota, Kurnatowska Alicja, Wilczyński Jan
    Źródło: Wiad. Parazytol. 2002: 48 (3) s.263-269, il., tab., bibliogr. [17] poz., sum.
    Sygnatura GBL: 303,658

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Preganancy is considered a factor of vulvovaginal mycosis. Secretion of hydrolases is an important determinantof Candida virulence. Thus, the aim of the study was to found the relationship between activity of 19 hydrolases in fungi isolated from vagina of pregnant women and symptoms of mycosis. 251 pregnant women were examined. Samples were collected from vagina and cultured on Sabouraud media. Activity of hydrolytic enzymes was evaluated using API ZYM (bioMerieux) test. Fungi were found in 20.1 p.c. of vaginal smples. Symptoms were detected in 45.8 p.c. of women. Only 32.1 p.c. of women with discharge and 26.4 p.c. with pruiritus had mycosis. Out of the 19 examined hydorlazes, 13 active enzymes were detected in fungal strains. We found for the first time the relationship betweeen acitivity of gunal esterase lipase and and the presenceof vaginal discharge in pregnant women.


    432/2523

    Tytuł oryginału: Acta Microbiologica Polonica
    Tytuł angielski: Green fluorescent protein as a molecular marker in microbiology.
    Autorzy: Rosochacki Stanisław Józef, Matejczyk Marzena
    Źródło: Acta Microbiol. Pol. 2002: 51 (3) s.205-216, il., tab., bibliogr. s. 214-216
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Molecular markers such as: lacZ(b-galactosidase), xylE (catechol 2,3-dioxygenase), lux (bacterial luciferase), luc (insect luciferase), phoA (alkaline phosphatase), gusA and gur AA (á-glucuronidase), gfp (green fluorescent protein), bla (á-lactamase) and other antibiotic resistance markers, heavy metals resistance genes are commonly used in environmental microorganisms research (Errampalli et al., 1998; Kohler et al., 1999). Most of these markers require one or more substrates, complex media and/or expensive equipment for detection. The gfp gene is widely used as a marker because of its very useful properteis such as high stability, minimal toxicity, non-invasive detection and the ability to generate tha green light without addition of external cofactors and without application of expensive equipment. Various applications of that reporter gene were showed starting from onitoring of microorganism's survival in complex biological systems such as activatedsludge to biodegradation of chemical compounds in soil. GFP allowed the detection, determination of spatial location and enumeration of bacterial cells from diverse environmental samples such as biofilm and water. The gfp as a biomarker was very useful in monitoring of gene expression and protein localisation in bacterial cells, too. The techniques with using gfp marker promise to supply a better understanding of environmental processes. It can make possible to use that knowledge in designing more effective and more efficient methods of biodegradation of toxic compounds from different envirnonments.


    433/2523

    Tytuł oryginału: Effect of null mutations in dnaK and dnaJ genes on conjugational DNA transfer, proteolysis and novobiocin susceptibility of Escherichia coli.
    Autorzy: Modrzewska Magdalena, Karpiński Paweł, Grudniak Anna, Wolska Krystyna I.
    Źródło: Acta Microbiol. Pol. 2002: 51 (3) s.217-224, il., tab., bibliogr. s. 223-224
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Escherichia coli null dnaJ and dnaKdnaJ mutants, when introduced to Hfr donor, impair its ability to DNA transfer during conjugation. The additive effect of both mutations was shown. Lack of DnaK and DnaJ chaperones also decreasethe extent of proteolysis in mutant strains. This effect is seen only at 42řC. The influence of double dnaKdnaJ deletion but not single dnaJ deletion on novobiocin susceptibility was also demosntrated.


    434/2523

    Tytuł oryginału: Ability of Pseudomonas sp. to synthesize aminopeptidases in the presence of various carbon and nitrogen sources.
    Autorzy: Jankiewicz Urszula, Bielawski Wiesław
    Źródło: Acta Microbiol. Pol. 2002: 51 (3) s.247-254, il., bibliogr. [24] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A soil strain of Pseudomonas sp. is able to synthesize at least two aminopeptidases exhibiting high activity in the presence of Phe-á-NA and aAla-á-NA as substrates. Irrespective of the used substrate, total activity of studied enzymes was strongly related to concentrations of organic components (peptone, glutamic acid, glucose) in mineral media and was the higher, the higher the concentration. Tendency of changes in total activity was similar for alanyl- and phenylalanylaminopeptidase though their response to different concentrations of organic components was different. Specific activity measured in the presence of Phe-á-NA and Ala-á-NA as the substrates was not strictly dependent on increasing concentrations of organic commponents in the media. The highest specific activity of aminopeptiidase was obtained in the presene of Phe-á-NA as a substrate on the fifth day of culture in medium containing 1 p.c. glucose. The obtained results seem to indicate the inductive character of the studied aminopeptidases. On the other hand, howevere, they do not eclude other regulatory mechanisms of their synthesis, including catabolic repression.


    435/2523

    Tytuł oryginału: Primary resistance of Helicobacter pylori to antimicrobial agents in Polish children.
    Autorzy: Rożynek Elżbieta, Dzierżanowska-Fangrat Katarzyna, Celińska-Cedro Danuta, Jóźwiak Paulina, Madaliński Kazimierz, Dzierżanowska Danuta
    Źródło: Acta Microbiol. Pol. 2002: 51 (3) s.255-263, il., tab., bibliogr. s. 262-263
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Helicobacter pylori resistance to antimicrobial agents is an important factor compromising the efficacy of treatment. Therefore the aims of our study were: to determine the prevalence of H. pylori resistance to clarithromycin, metronidazole, amoxycillin and tetracycline in children prior to eradication therapy, to compare different methods of susceptibility testing and to detect mutations responsible for clarithromycin resistance. During 1996-2000, 259 H. pylori strains were isolated from antral gastric biopsies. Susceptibility to antimicrobials was determined by the agar dilution method and the Etest. Mutations in the 23S rRNA gene associated with clarithromycin resistance were analysed by PCR-RFLP and direct sequencing. Overall, ninety-six strains (37 p.c.) were resistant to both drugs. All cultures isolates were sensitive to amoxycillin and only one isolate (0.4 p.c.) was resistant to tetracycline. The agar dilution method and the Etest showed a perfect catergory correlation for clarithromycin and 4 p.c. discrepancies for metronidazole. Primary resistnace to clarithromycin was mainly associated with an A2143G mutation inthe 23S rRNA gene of H. pylori. The study highlight the high prevalence of H. pylori primary resistnace to clarithromycin in Polish children, which implies a need for pretreatment susceptibility testing.


    436/2523

    Tytuł oryginału: Antimicrobial acitivity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.
    Autorzy: Wolinowska Renata, Zajdel-Dąbrowska Jolanta, Starościak Bohdan J., Kazimierczuk Zygmunt
    Źródło: Acta Microbiol. Pol. 2002: 51 (3) s.265-273, il., tab., bibliogr. [16] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Antibacterial and antifungal activity of 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles, including a number of newly obtained derivatives, were examined by diffusion method (inhibition area diameter in solid agar medium) and minimum inhibitory concentration (MIC, in liquid and agar medium). Some of the derivatives tested affected fungal colonymorphology and exerted genotoxic effects in bacteria. Of the tested compounds, 5,6-dichlorosubstituted derivatives appeared the most active against the majority of microorganisms used.


    437/2523

    Tytuł oryginału: Highlights on the health status of the Polish population in 1999/2000.
    Tytuł polski: Najważniejsze informacje o sytuacji zdrowotnej ludności Polski w 1999/2000 roku.
    Autorzy: Wojtyniak Bogdan, Goryński Paweł, Seroka Wojciech
    Źródło: Prz. Epidemiol. 2002: 56 (1) s.179-192, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 301,250

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem prezentowanego opracownia jest zwięzłe przedstawienie najważniejszych aspektów aktualnej sytuacji zdrowotnej ludności Polski. W końcu roku 2000 liczba ludności Polski wynosiła 38 644 211, i zmalała o około 9300 w porównaniu do 1999 r. Ostatnie 2 lata to okres gdy populacja uległa zmniejszeniu u około 23 tys. i jest to sytuacja, która wystąpiła po raz pierwszy w powojennej historii Polski. Zaobserwowano także dalszy spadek liczby urodzeń żywych z 382,0 tys. w 1999 r. do 378,3 tys. w 2000 r. oraz zmniejszenie współczynników urodzeń z 9,9 do 9,8 na 1000 ludności. W 2000 r. liczba zgonów była niższa o 13,4 tys. niż w roku poprzednim a współczynnik umieralności ogólnej zmniejszył się z 987 do 952 zgonów na 1000 tys. ludności. Przeciętne dalsze trwanie życia rodzącego się chłopca wynosiło 69,7 lat a dziewczynki 78.0 lat i w porównaniu z 1999 r. dla chłopców jest to więcej o 0,9 roku a dla dziewczynek o 0,5 roku. Przeciętne dalsze trwanie życia mężczyzn w mieście jest dłuższe (70,0 lat) niż na wsi 69,4 lat) podczas gdy u kobiet sytuacja jest odwrotna (77,8 w mieście i 78,4 na wsi). Od 1991 r., gdy niekorzystne trendy w stanie zdrowia ludności Polski zostały odwrócone lub przynajmniej zahamowane, przeciętne dalsze trwanie życia wzrosło o 3,6 roku dla mężczyzn i o 2,7 roku dla kobiet. Od wielu lat główną przyczyną zgonów we Polsce są choroby układu krążenia. W 1999 r. były one odpowiedzialne za 48,7 proc. zgonów (43,6 p.c. u mężczyzn i 54,5 proc. u kobiet). Standaryzowane współczynniki umieralności z powodu chorób układu krążenia malały od 1991r. i w 1999 r. były o 10 proc. niższe niż w 1996 r....

    Streszczenie angielskie: In the paper we describe the main problems of the Polish population health status and their trends in the past year. A meaningful improvement in several health parametres can be noticed in Poland since 1991. In the year 2000 life expectancy was 69.7 and 78.0 for males and females respectively - an increase by 3.6 and 2.7 years in comparison with 1991 values. There have been declining trends in cardiovascular mortality, cancer mortality (more often in younger age groups), infant mortality, incidence of infectious disease. Mental health problems are the growing issue. It has been stresses that the pace of progress is far too slow to achieve the level of health indicators in EU countries in the not too distant future.


    438/2523

    Tytuł oryginału: The rate of eyelid reflex loss following thiopental administration in hypo- and hypergonadism in rabbits.
    Autorzy: Szymański Bogdan, Pakulski Cezary, Drobnik Leon, Starczewski Andrzej, Badowicz Beata
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR179-BR183, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: The aim of this research was to explain whether different hormonal conditions caused by disturbed concentrations of estrogens and progesterone might lead to alteration of CNS reaction following administration of the hypnotic agent thiopental. The investigated factor was the rate of loss of the eyelid reflx after intravenous thiopental administration, since this corresponds with loss of consciousness. The investigation was performed in 24 sexually mature female Chinchilla rabbaits divided into 4 groups of 6 rabbits each. The animals were oophorectomized (hypoprogesterone/hypoestrogen), hyperestrogen (sham surgery plus estradiol injections), or normal (sham surgery). Twelve weeks later, thiopental (40 mg/ml) was infused through the intravenous cannula at a constant rate (90 ml/hour) until loss of the eyelid reflex, at which time blood was sampled for determination of thiopental, á-estradiol, progesterone and 17ŕ-hydroxyprogesterone concentrations. The ANOVA and Tukey tests were applied in statistical analysis (p = 0.05). Hyperprogesterone rabbits lost consciousness faster (138 ń 34.6 sec), at a lower plasma thiopental concentration (46.3 ń 6.6 ćg/ml), and required less thiopental (24.63 ń 6.44 mg/kg) than controls; hypoprogesterone rabbits lost consciousness slover (207.5 ń 30.9 sec), at a higher plasma thiopental concentration (129.2 ń 24.9 ćg/ml), and required more tiopental (38.51 ń 2.33 mg/kg) than controls. The time of sleep induction in the control group was 190 ń 25.7 sec.; the serum thiopental concentration was 77.8 ń 13.9 ćg/ml, and the total thiopental consumption was 35.8 ń 3.51 mg/kg. Estrogen status has no effect. Various hormonal states are accompanied by different CNS reactions to thiopental. Among the studied groups of sex steroids, only progestins significantly modify the CNS response to barbiturate infusion.


    439/2523

    Tytuł oryginału: Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus.
    Autorzy: Śmiałowska M., Szewczyk B., Brański P., Wierońska J. M., Pałucha A., Bajkowska M., Pilc A.
    Źródło: Neuropharmacology 2002: 42 (8) s.1016-1023, il., bibliogr. s. 1022-1023
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Previous studied showed that chronic electroconvulsive shock (ECS) or impiramine treatment induced a subsensitivity of group I metabotropic glutamate receptors (mGluR) in hippocampus. In the present study effects of antidepressant treatment on the expression og mGluR1a and mGluR5a, belonging to the group I mGluR, were investigated in rat brain hippocampus using immunohistochemical and Western blot methods, respectively. Male Wistar were treated singly or chronically for 21 days with imipramine, 10 mg/kg, twice daily; with ECS (90 mA, 50 Hz, 0.5 s) every second day; or with haloperidol, 1.2 mg/kg, once daily. Appropriate controls were injected with saline. Rats were sacrificed 24 h after last treatment and their hippocampi were taken out for analysis. It was found that the mGluR1a-immunoreactivity expression increased significantly in Ammon's horn (CA) regions after chronic ECS. The most pronounced effect was observed in the CA3. No significant effects were found after single treatment or after haloperidol. The expression of mGluR5a increased significantly after chronic impiramine in the CA1 and after chronic ECS in the CA3 region. The results obtained indicate an influence of antidepressant treatment on group I mGluR. This increase in the receptor protein level may be a compensatory mechanism developing after chronic treatment.


    440/2523

    Tytuł oryginału: Neuropharmacology
    Tytuł angielski: Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats.
    Autorzy: Rogóż Zofia, Skuza Grażyna, Maj Jerzy, Danysz Wojciech
    Źródło: Neuropharmacology 2002: 42 (8) s.1024-1030, il., bibliogr. s. 1029-1030
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: In spite of intensive research, the problem of treating antidepressant-resistant depressive patients has not yet been solved. The authors previously reported that combined administration of imipramine and ther uncomperative NMDA receptor antagonist amantadine reduced immobility time in the swimming test in rats to a much greater extent than treatment alone. The present paper investigates the possibility of synergistic interactions between there antidepressants (imipramine, venlafaxine, fluoxetine) with three uncompetitive NMDA receptor antagonists (imatadine, memantine and neramexane). Most combinations resulted in synergistic (hyperadditive) antidepressive-like effects in the forced swim test. Most interesing was the observation that fluoxetine, which was inactive when given alone, showed a positive effect when combined with amantadine (10 and 20 mg/kg), memantine (2.5 and 5 mg/kg) or neramexane (2.5 and 5 mg/kg). The specificyty of these observations is supported by control open field studies, which demonstrated no significant increase, or even a decrease in general locomotion after coadministration of the compounds. The present results suggest that the combination of traditional antidepressant drugs and NMDA receptor antagonists may produce enhanced antidepressive effects, and this is of particular relevance for antidepressant-resistant patients.


    441/2523

    Tytuł oryginału: Treatment of posterior and anterior urethral trauma.
    Autorzy: Dobrowolski Z[ygmunt] F., Węglarz W., Jakubik P., Lipczyński W., Dobrowolska B.
    Źródło: Br. J. Urol. 2002: 89 (7) s.752-754, bibliogr. 9 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective. To assess the occurence and treatment of posterior uretheral (most often caused by traffic accidents and comprising half of all cases of urinary tract traumas) and anterior uretheral injury (usually iatrogenic during catheterization or cystoscopy, or caused by blunt trauma, e.g. straddle injury or penetrating trauma). Patients and methods: The records and details of patients with posterior and anterior urethral trauma were analysed from 61 urological depatrments in Poland between 1995 and 1999. Results: During the 5-year period there were 268 cases of posterior and 255 of anterior uretheral injury; for the former, most occurred during traffic accidents, and of the latter 206 were iatrogenic (during catheterization or cystoscopy), of which 48 were accompanied by perineal injury. The posterior injuries were isoplated or involved many organs, mainly pelvic bones. Both types of injuries were diagnosed using ascending urethrography, voiding cysto-urethrography and urethroscopy/endoscopy. Treatment for posterior injuries included cystostomy alone or cystostomy with abdominal drainage or perineal drainage; some patients also had their urethra reconstructed. The treatment for anterior injuries was conservative in 193 patients and surgical in 62. Conclusion: The early detection and appropriate surgical treatment of posterior and anterior urethral injury is crucial for the recovery of urethral function, and avoids many complications.


    442/2523

    Tytuł oryginału: Comparison of the bladder tumour antigen test with photodynamic diagnosis in patients with pathologically confirmed recurrent superficial urinary bladder tumours.
    Autorzy: Lipiński M., Jeromin L.
    Źródło: Br. J. Urol. 2002: 89 (7) s.757-759, bibliogr. 20 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective: To verify the sensitivity of the bladder tumour antigen (BTAstat, Bard Urological, Convington, GA) test against the sensitive procedure of photodynamic diagnosis (PDD), in which 5-aminolaevulinic acid (5-ALA, a precursor of fluorescent porphyrins) is absorbed by the tumour and detected by ultraviolet cystoscopy, in the early diagnosis of urinary bladder tumours. Patients and methods: Forty-three patients (31 men and 12 women, age range 21-87 years) were assessed after transurethral resection of their bladder tumour using the BTAstat test and PDD. Sixty-nine biopsies from suspect areas of bladder mucosa were taken during cystoscopy under ultraviolet light and all suspect lesions electrocoagulated. Results: Thirty-five patients (81 p.c.) had a positive BTAstat test; in these patients PDD detected malignant lesions (17 Ta1G1-2, two T1G2, two T1G3 and 14 Tis). In eight patients (19 p.c.) the BTAstat was negative but PDD detected three malignant lesions (two Tis and one TaG1). Conclusions: PDD is valuable for detecting bladder malignancy and can identify small lesions not detected by the BTAstat test.


    443/2523

    Tytuł oryginału: Transurethral microwave thermotherapy: first experiences in Poland.
    Autorzy: Jakubczyk T., Stokłosa A[ndrzej], Borkowski A[ndrzej], Habrat W., Dobrowolski Z[ygmunt F.]
    Źródło: Br. J. Urol. 2002: 89 (7) s.767-770, tab., bibiliogr. 21 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Objective: To present early experiences in Poland with high-energy transurethral microwave thermotherapy (HeTUMT), considered as a serious alternative to surgery in managing benign prostatic hypertrophy (BPH). Patients and methods: Sixty-one patients were treated in two centres using a commercial TUMT system. The patients were assessed at 5-6 weeks, 3 and 6 months after treatment, evaluating subjective complaints, the International Prostate Symptom Score (IPSS), urinary flow rate and postvoid residual volume. Results: A complete follow-up was available in 44 patients; most had symptomatic improvement 3 months after HeTUMT but it was slightly less pronounced after 6 months. The improvement in objective variables increased up to 6 months after HeTUMT. There was ň 50 p.c. improvement in subjective complaints in 43 p.c. of the patients, in urinary flow rate in 25 p.c. and in residual urine in half. Two patients required re-treatment for a urethral stricture and ineffective HeTUMT. Conclusions: HeTUMT may be a useful treatment for BPH but the outcome for an individual patient seems to be unpredictable. The indications for TUMT should be reviewed individually for each patient.


    444/2523

    Tytuł oryginału: The efficacy of terazosin for treating benign prostatic hyperplasia: a multicentre clinical trial.
    Autorzy: Miękoś E[ugeniusz], Trzepizur Z., Różański W., Boniecki R., Kuśnierz J., Jabłonowski Z., Zydek C.
    Źródło: Br. J. Urol. 2002: 89 (7) s.771-772, tab., bibliogr. 7 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • urologia
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska


    445/2523

    Tytuł oryginału: The therapy of benign prostatic hyperplasia using less-invasive procedures: the current situation.
    Autorzy: Pomer S., Dobrowolski Z[ygmunt] F.
    Źródło: Br. J. Urol. 2002: 89 (7) s.773-775, bibliogr. 14 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    446/2523

    Tytuł oryginału: Microangiographic imaging of the prostate.
    Autorzy: Słojewski M[arcin], Czerwiński F[lorian], Sikorski A[ndrzej]
    Źródło: Br. J. Urol. 2002: 89 (7) s.776-778, il., bibliogr. 11 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: To present the results of microangiography in visualizing prostatic microvascularization. Materials and methiods: A contarst medium was injected into the vessels of prostate specimens obtained during surgery, to fill small vessels; nine specimens were obtained after cystoprostatectomy and two after radical prostatectomy. Branches of prostatic or seminal vesicle arteries were used for the injection, the specimens then fixed in formalin, sectioned and X-rayed. Results: In five samples the quality of the images was sufficient to visualize small arteries; the remaining vessels were partially filled. The vascular map was compared with previous results from historadiographic studies. Conclusions: Microangiographic imaging of prostate specimens provides a unique view of the angioarchitecture of the prostate and correlates closely with historadiographic studies. The correlation with other imaging methods, e.g. Doppler ultrasonography, needs further evaluation.


    447/2523

    Tytuł oryginału: Usefulness of power Doppler ultarsonography in evaluating erectile dysfunction.
    Autorzy: Golubiński A. J., Sikorski A[ndrzej]
    Źródło: Br. J. Urol. 2002: 89 (7) s.779-782, il., bibliogr. 16 poz.
    Sygnatura GBL: 300,816

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Objective: To evaluate deep penile arterial flow after an intracavernosal injection with papaverine in patients with erectile dysfunction (ED). Patients and methods: Twenty patients with ED were evaluated using power Doppler ultrasonography with a linear probe (8 MHz). Diagnostic tests were undertaken after an intracavernosal injection with 40 mg papaverine. The peak systolic velocity (PSV), enddiastolic velocity (EDV) and resistive index (RI) were analysed. Results: After injecting papaverine, seven patients had a normal erection and appropriate waveform patterns; their mean PSV was 30.7 cm/s, the EDV 4.42 cm/s and the RI 0.85. There was tumescence and elongation of the penis with no rigidity in eight patients; their mean PSV was 23.9 cm/s, the EDV 7.34 cm/s and the RI 0.72. There was no erection in five patients. The abnormal flow values showed insufficient arterial vessels in a quarter of the men, venous leakage in 15 p.c. and mixed ED in 20 p.c. Conclusion: The power Doppler technique allows the accurate location and evaluation of deep penile arteries. Vascular pathology may be differentiated after an intracavernosal injection with a vasomotor agent. Recognising the pathological pattern assists in choosing the best method of treatment.


    448/2523

    Tytuł oryginału: Brain Research
    Tytuł angielski: Expression and kinetic properties of Na+ currents in rat cardiac dorsal root ganglion neurons.
    Autorzy: Rola Rafał, Szulczyk Bartłomiej, Szulczyk Paweł, Witkowski Grzegorz
    Źródło: Brain Res. 2002: 947 (1) s.67-77, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 312,085

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The expression and properties of voltage-gated Na+ currents in cardiac dorsal root ganglion (DRG) neurons were assessed in this study. Cardiac DRG neurons were labelled by injecting the Fast Blue fluorescent tracer into the pericardium. Recordings were performed from 138 cells. Voltage-dependent Na+ currents were found in 115 neurons. There were 109 neurons in which both tetrodotoxin-sensitive (TTX-S, blocked by 1 ćM of TTX) and tetrodotoxin-resistant (TTX-R, insensitive to 1 ćM of TTX) Na+ currents were present. Five cells expressed TTX-R current only and one cell only the TTX-S current. The kinetic properties of Na+ currents and action potential waveform parameters were measured in neurons with cell membrane capacitance ranging from 15 to 75 pF. The densities of TTX-R (110.0 pA/pF) and TTX-S (126.1 pA/pF) currents were not significantly different. Current threshold was significantly higher for TTX-R (-34 mV) than for TTX-S (-40.4 mV) currents. V1/2 of activation for TTX-S current (-19.6 mV) was significantly more negative than for TTX-R current (-9.2 mV), but k factors did not differ significantly. V1/2 and the k constant for inactivation for TTX-S currents were -35.6 and -5.7 mV, respectively. These values were significantly lower than those recorded for TTX-R current for which V1/2 and k were -62.3 and -7.7 mV, respectively. The action potential threshold was lower, the 10-90 p.c. rise time and potential with were shorter before than after the application of TTX. Based on this we drew the conclusion that action potential recorded before adding tetrodotoxin was mainly...


    449/2523

    Tytuł oryginału: Effect of cytoprotectants on in vitro drug sensitivity of leukemic cells.
    Tytuł polski: Badania in vitro wpływu leków cytoprotekcyjnych na wrażliwość komórek białaczkowych na cytostatyki.
    Autorzy: Styczyński J[an], Wysocki M[ichał], Dębski R., Kubicka M., Balwierz W[alentyna], Juraszewska E., Rokicka-Milewska R[oma], Malinowska I., Matysiak M[ichał], Stańczak E., Balcerska A., Płoszyńska A[nna], Kowalczyk J[erzy], Stefaniak J., Małek U., Wachowiak J[acek], Mazur B., Sońta-Jakimczyk D[anuta], Szczepański T., Krawczuk-Rybak M., Chybicka A[licja], Raś M.
    Źródło: Pediatr. Prakt. 2002: 10 (2) : Prace nadesłane na Ogólnopolską Konferencję Naukową "Wybrane problemy zdrowotne dzieci i młodzieży u progu XXI wieku" : [sesja naukowa] "Onkologia dziecięca : postępy w diagnostyce i terapii" s.37-40, il., bibiogr. 6 poz., streszcz. - Ogólnopolska konferencja naukowa pt. Wybrane problemy zdrowotne dzieci i młodzieży u progu XXI wieku - sesja naukowa pt. Onkologia dziecięca - postępy w diagnostyce i terapii Poznań 18-20.04. 2002
    Sygnatura GBL: 306,430

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • hematologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie polskie: Celem pracy była ocena wpływu in vitro leków cytoprotekcyjnych: dexrazoxanu (DEX) oraz amifostyny (AMF) na cytotoksyczność daunorubicyny (DNR) i 4-HOO-ifosfamidu (IFO) w linii K562 i w ostrych białaczkach u dzieci. Cytotoksyczność DEX i AMF oraz ich kombinacji z odpowiednimi cytostatykami oceniono w teście MTT w komórkach linii K562 oraz u 18 dzieci z ALL (12 de novo, 6 we wznowie) i 4 z AML de novo. Za miarę cytotoksyczności przyjęto wartość stężenia leku, w którym ginie 50 proc. badanych komórek (LC50). DEX i AMF zmniejszały przeżycie komórek linii K562 odpowiednio o 12 proc. i 20 proc. oraz zwiększały cytotoksyczność DNR i IFO. W stosunku do komórek białaczkowych, zaobserwowano silną korelację pomiędzy wartościami LC50 dla DNR i DNR+DEX (rho = 0,872, p=0,001), natomiast wartości LC50 dla DNR i DNR+DEX nie różniły się (0,50 mg/ml vs 0,55 mg/ml). Również dla IFO i IFO+AMF, stwierdzono korelację pomiędzy wartościami LC50 (rho = 0,64; p=0,01), jednak zaobserwowano tendencję do różnic pomiędzy wartościami LC50 dla IFO oraz dla IFO+AMF (p=0,073, współczynnik regresji liniowej 0,468). Mediana LC50 dla IFO wynosiła 20,23 mg/ml, natomiast dla IFO+AMF była równa 14,47 mg/ml (p=0,623). Przeprowadzone badania wskazują, że AMF może mieć niewielki wpływ cytotoksyczny in vitro na komórki białaczkowe oraz niewielki synergistyczny wpływ na cytotoksyczność IFO, natomiast DEX nie ma wływu na wrażliwość in vitro komórek białaczkowych na DNR.

    Streszczenie angielskie: The objective of the study was the analysis of effects of cytoprotectants: dexrazoxane (DEX) and amifostine (AMF) on in vitro drug sensitivity of K562 cells and childhood leukemic cells to daunorubicin (DNR) and 4-HOO-ifosfamide (IFO). Cytotoxicity of DEX and AMF and their combination with respective drugs was analyzed by means of the MTT assay in K562 cell line and and in 18 children with ALL (12 de novo, 6 relapsed) and 4 with AML de novo. Cytotoxicity was expressed by concentration of drug which was lethal to 50 p.c. of tested cells (LC50). DEX and AMF caused cell kill in K562 cell line by 12 p.c. and 20 p.c. respectively and increased cytotoxicity of DNR and IFO. Strong correlation was observed between LC50 values for DNR and combination DNR+DEX (rho = 0,872, p=0,001) in patients samples, while LC50 values did not differ significantly (0,50 mg/ml vs 0,55 mg/ml). The correlation was observed also between LC50 for IFO+AMF (rho = ),64; p=0,01), however tendency to higher resistance to IFO was observed, when compared to combination IFO=AMF (20,23 mg/ml vs 14,47 mg/ml; p=0,623 Mann-Whitney U test; p=0,73 Wilcoxon matched pair test; regression coefficient 0,468). The results suggest weak in vitro cytotoxicity effect of AMF on leukemic cells and its weak synergistic effect on IFO cytotoxicity, while it seems that DEX has no influence on in vitro sensitivity of leukemic cells to DNR.


    450/2523

    Tytuł oryginału: New approaches to the treatment of pediatric atopic dermatitis.
    Tytuł polski: Postępy w leczeniu atopowego zapalenia skóry u dzieci.
    Autorzy: Berger William E.
    Źródło: Alerg. Astma Immunol. 2002: 7 supl. 2: Alergia, astma immunologia kliniczna: IV Konferencja Środkowo-Europejska: materiały naukowe s.40-48, il. - 4 Konferencja Środkowo-Europejska pt. Alergia, astma, immunologia kliniczna Łódź 12-15.06. 2002
    Sygnatura GBL: 313,342

    Hasła klasyfikacyjne GBL:
  • pediatria
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    451/2523

    Tytuł oryginału: Midfacial fractures in children.
    Autorzy: Kos M., Łuczak K., Godziński J., Rapala M., Klempous J.
    Źródło: Eur. J. Pediatr. Surg. 2002: 12 (4) s.218-225, il., tab., bibliogr. 20 poz., r‚s., res., Zsfg
    Sygnatura GBL: 312,942

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The purpose of the study was to present a modern classification and discuss the treatment of midfacial fractures in children. From the beginning of 1 January 1998 to 31 October 2000, 147 children were treated for different craniofacial fractures. Among them 28 patients (19 p.c.) had extensive midfacial fractures complicated by impaired vision and/or CNS dysfunction and were treated surgically. The fractures were divided into: zygomaticoorbital (1 pt) and zygomatico-orbito-maxillary (5 pts), isolated orbital wall fractures (14 pts) and naso-orbital dislocations (2 pts), upper facial portion dislocations (2 pts) and fronto-naso-orbital (2 pts) or cranio-orbital fractures (2 pts). Clinical examination revealed mainly dysfunction of facial morphology and aesthetics (enophthalmos, telecanthus), CSF leakage, impairment of vision and restricted eyeball movements. Ophthalmological, neurological and radiological (Waters view, CT, NMR) examinations were performed in all cases. The treatment consisted of bone repositioning, reconstruction with autologus bone grafts and three-dimensional stabilisation using titanium plates. Twenty-three pts were operated on before and 5 pts after 7th day after trauma. The restoration of normal facial morphology was achieved in 26 patients. In 2 cases it was imposisible because of the destruction of soft tissue and an extremely extensive bony trauma. Better reposition of bony fragments, prompt healing and better final results were achieved in patients operated before day 7 after trauma. Achieving good results in midfacial fractures requires prompt...


    452/2523

    Tytuł oryginału: Minimally invasive repair of pectus excavatum - the nuss procedure. A European Multicentre Experience.
    Autorzy: Hosie S., Sitkiewicz T., Petersen C., G”bel P., Schaarschmidt K., Till H., Noatnick M., Winiker H., Hagl C., Schmedding A., Waag K.-L.
    Źródło: Eur. J. Pediatr. Surg. 2002: 12 (4) s.235-238, il., tab., bibliogr. 5 poz., r‚s., res., Zsfg
    Sygnatura GBL: 312,942

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Since the first description in 1998, the minimally invasive reapir of pectus excavatum has gained increasing acceptance. The aim of this survery is to report on the experiences of eight European centres with this technique. 172 patients with a mean age of 15.1 (ń4.6) years were treated and evaluated, 35.5 p.c. were sympomatic. 45.3 p.c. of the patients had an asymmetric configuration of the chest, 74.3 p.c. had a CT index above 3.25. Mean duration of the operative procedure was 76 minutes. Major complications, including dislocation of the bar or stabiliser, pneumonia, atelectasis, local infection, pleural and pericardial effusion and liver injury occurred in 11.1 p.c. of the patients. Minor complications, such as self-resolving pneumothorax, atelectasis and subcutaneous emphysema were reported in another 8.1 p.c. Early cosmetic results were excellent or good in 81.5 p.c. Although the surgical procedure is simple, blood-sparing and short, consideration of some important technical details, proper patient selection and knowledge of the limitations is of vital importance. Long-term results are still lacking.


    453/2523

    Tytuł oryginału: Perspetives of clinical application of bone morphogenetic proteins in children.
    Autorzy: Kos M., Łuczak K., Matusiewicz M., Krzystek-Korpacka M., Rapala M.
    Źródło: Eur. J. Pediatr. Surg. 2002: 12 (4) s.272-277, il., bibliogr. 20 poz., r‚s., res., Zsfg
    Sygnatura GBL: 312,942

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło
  • szczury

    Streszczenie angielskie: The purpose of the study was to modify the method of Bone Morphogenetic Protein (BMP) extraction from bovine bones, estimate the osteoinductive potential of the extracted protein fractions in relation to the degree of protein purity and to test collagen formed in porous discs as a carrier. It was required before BMP application in reconstructive surgery in children. Material and method: BMP preparation from bovine bones was conducted according to a modification of Luyten's method. Three fractions of different degree of purity - demineralised bone matrix "M", extract "E", and fraction after hydroxyapatite column "HP" - were tested for their osteoinductive potential. They were implanted on a collagen carrier into the right rat femoral muscle pouch. Controls were implanted in the same way in the left muscle pouch. The discs were removed after 3 and 6 weeks and tested for alkaline phosphatase activity, a marker of new bone formation. Results: Out of the 10 animals used for testing the osteoinductive potential of matrix fraction, 7 results were positive and 3 negative. In the case of the extract fraction, the analysis was conducted for 3 weeks on 9 rats and 6 weeks on 13 rats. Six and 11 positive results were obtained, respectively. In the HP group 5 animals were observed for 3 weeks (3 positive, 2 negative) and 10 animals for 6 weeks (7 positive, 3 negative). In the case of the extract, the differences in alkaline phosphatase activity after 6 weeks were statistically significant (p ó 0.05) compared to controls. In the other groups, a positive tendency was observed...


    454/2523

    Tytuł oryginału: Effect of NADH on the redox state of human hemoglobin.
    Autorzy: Olek Robert A., Antosiewicz Jędrzej, Caulini Gian Carlo, Falcioni Giancarlo
    Źródło: Clin. Chim. Acta 2002: 324 (1/2) s.129-134, il., bibliogr. 15 poz.
    Sygnatura GBL: 303,881

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In this work, we report that NADH can increase the autoxidation rate of hemoglobin (HbA) in a pH-dependent fashion. During this process, this cofactor is itself oxidized. The presence of superoxide dismuatase (SOD) and/or catalase (CAT) can inhibit this result. At lower pH rates, the effect of NADH on the hemoglobin autoxidation rate is more enhanced, in addition, the rate of NADH oxidation is increased. Our data indicates that the reduced pyridine nucleotide may influence the redox state of human hemoglobin by a mechanism, which probably involvews free radical species.


    455/2523

    Tytuł oryginału: Effect of Helicobacter pylori on delay in ulcer healing induced by aspirin in rats.
    Autorzy: Konturek Peter C., Brzozowski Tomasz, Kwiecień Sławomir, Drozdowicz Danuta, Harsch Igor A., Meixner Holger, Stachura Jerzy, Hahn Eckhart G., Konturek Stanisław J.
    Źródło: Eur. J. Pharmacol. 2002: 451 (2) s.191-202, il., tab., bibliogr [37] poz.
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) are major pathogenic factors in peptic ulcer disease but whether these two factors exert synergistic or antagonistic effects on ulcer healing has been a subject of controversy. We compared the effect of aspirin alonne with that of aspirin combined with H. pylori on gastric acid secretion and healing of acetic gastric ulcers in rats. The H. pylori colonization of gastric mucosa was determined by viable H. pylori culture, histology and assessment of bacterial DNA using polymerase chain reaction (PCR). The area of ulcers, gastric blood flow, mucosal generation of prostaglandin E2 and plasma gastrin levels and expression of cyclooxygenase-1, cyclooxygenase-2 and growth factors was determined. Aspirin delayed significantly the healing of chronic gastric ulcers, decreased the gastric blood flow at the ulcer margin and gastric mucosal prostaglandin E2 heneration being without significant influence on gastric acid output H. pylori acquisition that produced moderate gastric inflammation at the ulcer margin delayed significantly the healing of gastric ulcers, decreased significantly both the gastric blood flow at the ulcer margin and the gastric secretion while raising significantly the gastric mucosal prostaglandin E2 generation and plasma gastrin levels. H. pylori infection attenuated the aspirin-induced inhibition of ulcer healing and accompanying fall in the gastric blood flow. Both aspirin and H. pylori up-regulated significantly cyclooxygenase-2 messenger RNA (mRNA)...


    456/2523

    Tytuł oryginału: Progastrin and cyclooxygenase-2 in colorectal cancer.
    Autorzy: Konturek Peter C., Bielański Władysław, Konturek Stanisław J., Hartwich Artur, Pierzchalski Piotr, Gonciarz Maciej, Marlicz Krzysztof, Starzyńska Teresa, Zuchowicz Monika, Darasz Zbigniew, G”tze Jens P., Rehfeld Jens F., Hahn Eckhart G.
    Źródło: Dig. Dis. Sci. 2002: 47 (9) s.1984-1991, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 310,037

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Colorectal cancers (CRCs) are one of the most common forms of cancer in Poland and one of the leading causes of dearh. The tumors have been attributed to genetic, dietary, and other environmemtal factors, but recently factors such as gastrin have also been implicated in the carcinogenesis. The relationship between plasma amidated and nonamidated gastrin in CRCs is controversial. This study was designed to determine the plasma levels of progastrin and amidated gastrin in 50 CRC patients before and 3-6 months after removal of the tumor, to determine the tumor concentrations of these gastrin peptides and the level of expression for gastrin mRNA and gastrin/CCKb receptor mRNA, to examine the expression of cyclooxygenase COX-1 and COX-2 in mRNA in CRC tissue, and to compare the prevalence of Hp and its cytotoxic protein, CagA, and cytokines (TNFŕ, IL-1á, and IL-8) in CRCs, before and after removal of tumor. It was found that thwe CRC, its resection margin, and the plasma contained severalfold higher levels of progastrin than of amidated gastrins and that the removal of the CRC tumor resulted in a marked reduction in plasma progastrin level without a significant alteration in plasma levels of amidated gastrins. Both gastrin and CCKb-R mRNA were detected in the cancer tissue and resection margin by RT-PCR, and similary, COX-1 and COX-2 mRNA were expressed in these tissues of moast CRCs. The seroprevalence of Hp, especially that expressing CagA, and levels of IL-1á, but not other cytokines, were significantly higher in CRC patients than in 100 age-...


    457/2523

    Tytuł oryginału: Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
    Autorzy: Pilc A., Kłodzińska A., Brański P., Nowak G., Pałucha A., Szewczyk B., Tatarczyńska E., Chojnacka-Wójcik E., Wierońska J. M.
    Źródło: Neuropharmacology 2002: 43 (2) s.181-187, il., tab., bibliogr. s. 186-187
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Several lines of evidence suggest a crucial involvement of glutamate in the mechanism of action of anxiolytic and antidepressant drugs. The involvement of group I mGLu receptors in anxiety and depression has also been proposed. In view of the recent discovery of anxiolytic- or antidepressant-like effects of acute injections of 2-methyl-6-(phenylethyl)-pyridine (MPEP), a selective and brain penetrable mGlu5 receptor antagonist, we designed the present study to examine anxiolytic- and/or antidepressant-like effects of multiple administration of this drug. The anxiolytic-like effects of MPEP were evaluated in rats using the conflict drinking test. The antidepressant-like effect was estimated using the rat olfactory bulbectomy model of depression. Seven subsequent injections of MPEP (1 mg/kg) significantly (by 320 p.c.) increased the number of shock accepted during the experimental session in the Vogel test. MPEP given once daily at a dose of 10 mg/kg, restored the learning deficit of bulbectomized rats after 14 days of treatment, remaining without any effect in the sham-operated animals. N-methyl-D-aspartic acid (NMDA)-induced convulsions in mice were not affected by a single injection of MPEP (30 mg/kg) indicating that at this dose MPEP did not block NMDA receptors. The results indicate that the prolonged blockade of mGlu5 receptors exert anxiolytic- and antidepressant-like effects in rats. No tolerance to anxiolytic-like action occurs. The previously mentioned results further indicate that antagonists of group I mGlu receptors may play a role in the therapy of both anxiety and depression.


    458/2523

    Tytuł oryginału: Efficacy and safety of TTS fentanyl given directly after tramadol to patients with cancer related pain (based on FEN-POL-2 trial).
    Tytuł polski: Ocena efektywności i bezpieczeństwa stosowania TTS fentanylu bezpośrednio po tramadolu, u pacjentów z bólem pochodzenia nowotworowego (na podstawie badania FEN-POL-2 trial).
    Autorzy: Łuczak Jacek, Gorzelińska Lidia, Ramlau Rodryg, Wojtukiewicz Marek, Koralewski Piotr, Krzakowski Maciej, Załuski Jerzy
    Źródło: Nowotwory 2002: 52 (3) s.216-220, il., tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem badania była ocena skuteczności i bezpieczeństwa stosowania TTS fentanylu u chorych z bólem nowotworowym, którzy poprzednio nie otrzymywali silnych opioidów. Do badania włączono 72 pacjentów, leczonych przez ostatnie 3 dni traumadolem w dawce 400 mg na dobę z niedostatecznym efektem przeciwbólowym. Natężenie bólu oceniano za pomocą Wizualnej Skali Analogowej (VAS) oraz Słownej Skali Oceny Bólu (VRS). U wszystkich badanych stosowanie TTS fentanylu rozpoczęto od dawki 25 ćg/godz, a w razie wystąpienia bólu przebijającego podawano 5 mg roztworu wodnego szybko działającej morfiny lub nie opioidowe leki przeciwbólowe. Podczas badania dawkę początkową TTS fentanylu utrzymano u 18 chorych, pozostali wymagali zwiększenia dawek. Maksymalna dawka wynosiła 150 ćg/godz. i była stosowana u 2 pacjentów. Trwające 28 dni badanie ukończyło 64 chorych. W ostatnim dniu badania 45/64 (72 proc.) chroych zgłaszało brak bólu lub ból o nieznacznym nasileniu, 15/64 (22 proc.) ból o średnim natężeniu, a 4/64 (6 proc.) ból silny lub bardzo silny wg VRS. W trakcie badania wystąpiły następujące objawy uboczne: nudności (N = 3), wymioty (N = 3), zaparcie stolca (N = 2) i wzmożona potliwość (N = 1), u żadnego z badanych nie pojawiły się objawy depresji oddechowej. TTS fentanyl okazał się skutecznym i bezpiecznym środkiem w leczeniu bólu nowotworowego nie pobierających wcześniej silnych opioidów.

    Streszczenie angielskie: The main purpose of the trial was to investigate the clinical efficacy and safety of TTS fentanyl administered over 28 days to patients naive to strong opioids, treated over the past 3 days prior to entering the study with the maximal (400 mg) daily dose of traumadol. Seventy two patients were included in the study, all of them suffering from advanced cancer-related pain. All patients started with the lowerst available dose of fentanyl (Delivery rate 25 ćg/hr. If analgesia was insufficient, the patients were give a strong opiid (5 mg of immediate-release oral morphine) or a non- opioid analgesic as "rescue" medication. Pain intensity was evaluated by means of the Visual Analoque Scale (VAS) and the Verbal Rating Scale (VRS). Sixty four patients were eligible for analysis. During the study 18 patients continued with 25 ćg/hr, and the remaining was administerd a higher doses. The maximum does was 150 ćg/hr (2 patients). At the termination of the trial 45/64 (72 p.c.) patients had no pain or slight pain, 15/564 (22 p.c.) had moderate pain and 4/64 (6 p.c.) experienced strong or very strong pain (VRS). At the end of the trial in 51/64 (79 p.c.) pts pain control was good to excellent (in an overall assessment of pain treatment). Clinically relevant respiratory depression was not observed. The following side effects of opioids were observed: nausea (N = 3), vomiting (N = 3), constipation (N = 2) and sweating (N = 1). Transdermal fentanyl proved to be an effective and safe analgesic in the treatment of cancer-related pain in patients naive to strong opioids.


    459/2523

    Tytuł oryginału: Papilomavirusines infekcijos paplitimas tarp ligoniu, serganciu gerklu papilomatoze, ir kai kuriu rizikos veiksniu itaka papilomavirusu persistavimui virsutiniuose kvepavimo takuose.
    Tytuł angielski: Prevalence of human papillomavirus infection among patients with laryngeal papillomatosis and the influence of some risk factors on the persistence of papillomaviruses in the upper respiratory tract.
    Autorzy: Velyvyte Daiva, Laiskonis Alvydas, Uloza Virgilijus, Goździcka-Józefiak Anna
    Źródło: Medicina 2002: 38 (5) s.499-504, tab., bibliogr. 19 poz., sum.
    Sygnatura GBL: 313,016

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Infection with high-risk human papillomaviruses is a significant risk factor of various benign and malignant human lesions in the upper respiratory tract, skin and the genital tract. The identification of particular human papillomaviruses types is important fir identifying patients with premalignant lesions who are at risk of progression to malignancy. Our aim was to establish the prevalence of human papillomaviruses infection in the upper respiratory tract of patients with laryngeal papillomatosis, to identify viral types, to evaluate the relationship between some risk factors and persistence of human papillomviruses in the upper respiratory tract and to determine the pattern of human papilomaviruses infection. Material and methods. The gorup fo 36 patients with laryngeal papillomatosis and control group of 108 persons without any complains of respiratory system was examined. Epidemiologic characteristics and objective data were analyzed and routine laryngological examination was performed. Pharyngeal swabs of all persons and laryngeal biopsies of 17 patients were taken and analyzed for the presence fo human papillomaviruses DNA. Viral typing using the polymerase chain reaction was performed. Results. Human papillomaviruses DNA was detected in all except one case of laryngeal papillomatosis; then only 23.15 p.c. of persons without complaints of respiratory system were found human papillomaviruses positive. Human papillomaviruses 6, 11 types were predominant (in 88.9 p.c. of patients adn 19.4 p.c. of persons from control gorup). High-risk human papillomaviruses were detected in 52.78 p.c. of laryngeal papillomatosis cases and in 9.26e p.c. of control cases. Risk factors were noted statistically significantly more often in human papillomaviruses positive cases...


    460/2523

    Tytuł oryginału: Polymorphonuclear leukocyte collagenase as an indicator of the juvenile idiopathic arthritis activity.
    Tytuł polski: Kolagenaza leukocytów krwi obwodowej jako wskaźnik aktywności młodzieńczego idiopatycznego zapalenia stawów.
    Autorzy: Musiej-Nowakowska Elżbieta, Wojtecka-Łukasik Elżbieta, Maśliński Sławomir
    Źródło: Reumatologia 2002: 40 (1) s.5-13, tab., bibliogr. 42 poz., sum.
    Sygnatura GBL: 304,900

    Hasła klasyfikacyjne GBL:
  • reumatologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: U 58 dzieci chorych na idiopatyczne młodzieńcze zapalenie stawów (mizs.) oceniono zmiany aktywnej i latentnej formy kolagenazy granulocytów obojętnochłonnych (PNM) krwi obwodowej, z uwzględnieniem liczby leukocytów krwi obwodowej, 3 postaci klinicznych mizs., aktywności klinicznej i laboratoryjnej choroby oraz obecności wysięku stawowego u ocenianych chorych. Grupę kontrolną stanowiło 23 zdrowych dzieci. Stwierdzono istotnie statystycznie większą aktywność kolagenazy PNM leukocytów u dzieci z postacią uogólnioną i skąpostawową mizs. w porównaniu z grupą kontrolną. U chorych z postacią wielostawową choroby aktywność kolagenazy PNM leukocytów była niższa niż w grupie kontrolnej, ale różnice nie były statystycznie istotne. Liczba leukocytów krwi obwodowej nie korelowała z aktywnością kolagenazy PNM leukocytów. Wartości kolagenazy latentnej w komórkach krwi tylko chorych z postacią skąpostawową były istotnie wyższe od wartości tego enzymu w grupie kontrolnej. Wykazano istotne powiązanie pomiędzy aktywnością kolagenazy PNM leukocytów a obecnością wysięku stawowego u ocenianych chorych oraz podwyższenie aktywności enzymu u niektórych dzieci, u których rutynowe wskaźniki zapalenia były prawidłowe. Uzyskane wyniki wskazują, że PMN leukocyty dzieci chorych na mizs. są "częściowo" zaaktywowaane już na obwodzie, ale stopień ich aktywacji jest różny w wyodrębnionych podgrupach klinicznych. Aktywność badanego enzymu może być wartościowym wskaźnikiem aktywności choroby, szczególnie postaci skąpostawowej mizs.

    Streszczenie angielskie: In 58 children with JIA and 23 age-matched healthly controls the blood leukocyte PMN collagenase was determined. A significant increase in the level of active collagenase was observed in systemic and pauciarticular forms of JIA and a close positive relation was found between the level of both (active and laten) leukocyte collagenase and joint effusion. It is concluded that PMN - leukocytes in systemic and pauciaticular form are already "partially" activated in the peripheral blood and that the level of active leukocyte collagenase may be a valuble index of disease activity, especially in the pauciarticular form of JIA.


    461/2523

    Tytuł oryginału: The moral and ethical quandry of embryonic stem cell research.
    Autorzy: MacQueen Bruce Duncan
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.ED1-ED4, bibliogr. 4 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • transplantologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    462/2523

    Tytuł oryginału: Proinflammation: A common denominator or initiator of different pathophysiological disease processes.
    Autorzy: Esch Tobias, Stefano George B.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.HY1-HY9, il., bibliogr. 85 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Proinflammation is a widespread phenomenon. It has an association with the stress (patho)physiology and is connected with various diseases. Recently, it has been discussed if proinflammation may represent a common (pre)condition in defferent disease states. Evidence for a common proinflammatory pattern in a variety of diseases is analyzed. Proinflammatory (pre)conditions and immune response patterns serve as a common modality in a number of clinically separate diseases. Here, nitric oxide pathways often play a significant role as well. On molecular basis, proinflammation potentially illustrates a common denominator and/or an initiator. Like stress, proinflammation seems to be crucial autoregulatory concept. It normally serves a positive biological goal: Proinflammatory activities, e.g., are initiated to overcome infection or invasion of potentially deleterious biological agents (bacteria, viruses, parasites etc.). While fighting invasion, proinflammation usually shortens biological 'battles' and therefore ameliorates disease-related detrimental or subjectively unpleasing phenomena. However, proinflammation has beneficial and deteriorating capacities and may yet exert detrimental effects. This is especially true, when the fine balance between the different immune response pathways, between anti- and proinflammatory mechanisms, can not be kept. This may occur when a challenge becomes overwhelming or when paterns of a chronic (patho)physiological activity are presented. Thus, proinflammation may represent a relatively unspecific, overlapping/analogous state, underlying various clinical disease manifestations.


    463/2523

    Tytuł oryginału: Modulation of sickle cell crisis by naturally occurring band 3 specific antibodies - a malaria link.
    Autorzy: Kennedy James Randall
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.HY10-HY13, bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This paper's focus is prevention of sickle cell adhesion resulting from the erythrocyte's prematurely denatured hemoglobin. This denatured hemoglobin causes a molecule called band 3 to cluster on the erythrocyte's surface and adhere to the CD36 molecule located on the microvascular endothelium. Natural antibodies recognize these clusters on senescent erythrocytes and prevent their endothelial adhesion and target them for reticuloendothelial elimination. Band 3 is also displayed on the erythrocytes of individuals with falciparum malaria and the vasoocclusive pathology in these patients is prevented in individual with sickle trait. The hypothesis is that prematurely denatured sickle hemoglobin results in an up regulation of natural antibodies which control erythrocyte adhesion in boath malaria and sickle cell disease.


    464/2523

    Tytuł oryginału: Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
    Autorzy: Ellingsen Espen A., Morath Siegfried, Flo Trude H., Schromm Andra B., Hartung Thomas, Thiemermann Christoph, Espevik Terje, Golenbock Douglas T., Foster Simon J., Solberg Rigmor, Aasen Ansgar O., Wang Jacob E.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR149-BR156, il., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Pro-inflammatory potential of lipoteichoic acid (LTA) from Staphylococcus aureus is controversial. Present study was undertaken to examine ability of highly purified and characterized S. aureus LTA to stimulate production of pro-inflammatory cytokines in human leukocytes at both mRNA and protein level, and to study involvement of Toll-like receptors (TLRs) adn CD14 in this response. Purified LTA was administered to whole human blood ex-vivo (or primary adherent monocytes) and cytokine response assessed in plasma by EIA. Cytokine mRNA was measured by RT-PCR on leukocyate subsets isolated following stimulation. To study involvement of specific receptors for LTA signaling, CHO cells transfected with CD14 and/or TLR2, TLR4 were used, as well as antibodies directed against these receptors. Addition of highly purified LTA to a whole blood or primary adherent monocytes elicited a time and concentration dependent release of TNF-ŕ, IL-1á, IL-6 and IL-8. mRNA encoding TNF-ŕ, IL-1á, IL-6 and IL-8. mRNA encoding TNF-ŕ, IL-1á and IL-6 seemed to be accumulated in monocytes and T cells, but not in granulocytes and B cells. Expression of TLR2, but not TLR4, in chinese hamster ovary cells conferred responsiveness to LTA. However, antibodies directed towards TLR2 (clone TL2.1) or TLR4 (clone THA125) failed to inhibit TNF-ŕ release induced by LTA in the whole blood model and in adherent monocytes. In contrast, blockade of the CD14 receptor with MAb18D11 strongly attenuated LTA induced release of TNF-ŕ in both models.


    465/2523

    Tytuł oryginału: Gastric hyperemic response induced bay acid back-diffusion in rat stomachs following barrier disruption - relation to vanilloid type-1 receptors.
    Autorzy: Tashima Kimihito, Nakashima Masato, Kagawa Shigeru, Kato Shinichi, Takeuchi Koji
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR157-BR163, il., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Acid back-diffusion activates capsaicin-sensitive sensory neurons (CSN), leading to gastric hyperemic response. We examined the role of vanilloid type-1 receptor (VR1) in gastric hyperemic and ulcerogenic responses in rat stomach following exposure to taurocholate (TC). Under urethane anesthesia, a rat stomach was mounted on an ex-vivo chamber, perfused with 50 mM HCl, and changes in PD, gastric mucosal blood flow (GMBF), and luminal acid loss were measured before and after exposure to 20 mM TC for 30 min, in presence of omeprazole. Capsazepine was co-applied with TC for 30 min to the stomach, while ruthenium red was given i.v. 10 min before TC treatment. TC caused a marked PD reduction, followed by an increase of acid loss and GMBF, resultin in minimal damage in the mucosa. Chemical ablation of CSN attenuated the GMBF response to TC without affecting PD reduction and acid loss, and resulted in severe lesions, while none of these responses induced by TC was significantly affected by either capsazepine or ruthenium red. Intragastric capsaicin increased GMBF, and this response was attenuated by both capsazepine and ruthenium red as well as sensory deafferentation. Both acid back-diffusion and capsaicin increase GMBF mediated by CSN, yet their modes of action differ in terms of capsazepine- or ruthenium red-sensitvity. Although the luminal H+ plays a modulator role for the physiological response mediated by CSN in the stomach, it is unlikely that the action results from the interaction of H+ with the capsazepine- or ruthenium red-sensitive site of VR1.


    466/2523

    Tytuł oryginału: Endothelin-1 gene polymorphism in the identification of patients at risk for malignant ventricular arrhythmia.
    Autorzy: Kozak Milan, Holla-Izakovicowa Lydie, Krivan Lubomir, Vaśku Anna, Sepsi Milan, Semrad Borivoj Semrad, Vacha Jiri
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR164-BR167, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The endothelins are peptides with vasoconstricting and growth-promoting properties. Endthelin-1 (ET-1) is known for its direct positive inotropic and chronotropic effects on isolated heart, and for growth effects. The aim of this pilot study was to investigate the frequency distribution of a common polymorphism of the endothelin (ET-1) gene and its possible relation to the hemodynamic consequences of malignant ventricular arrhythmia in patients with structural heart disease. We studied 26 consecutive patients with malignant ventricular arrhythmia and implantable cardioverter defibrillators (ICD), mean age 62.7 ń 12.2 years, mean LVEF 0.37 ń 0.37 ń 11. The Taq polymorphism of ET-1 was detected using our original PCR method. The PCR product with a length of 358 bp in its non-mutated form contains a target sequence for the TaqI restrictive enzyme, while the mutated product loses this cleavage site. Out of the 26 patients, 9 (34 p.c.) had recurrent palpitations and 8 (30.8 p.c.) had syncopes during their malignant arrhythmic episodes. 19 of the patients were receiving amiodarone after ICD implantation, 7 were not. 15 patients had the (+ +) adn 11 had the (+ -) ET-1 genotype; none had the (- -) genotype. The risk of syncopes was associated with the (+ +) genotype (p = 0.01). Patients with amiodarone had a significantly higher frequency of the (+ +) genotype (p = 0.011). All our results suggested that the presence of the (+ +)ET-1 genotype in patients with structural heart disease, severe left ventricular dysfunction, and malignant ventricular arrhythmia put these patients at a higher risk of hemodynamic collapse during arrhythmic episodes.


    467/2523

    Tytuł oryginału: Proteinases from Bacillus intermedius secreted in the late stages of sporulation.
    Autorzy: Balaban Nelly P., Gabdrakhmanova Leila A., Sharipova Margarita R., Mardanova Aislu M., Sokolova Evgeniya A., Rudenskaya Galina N., Leshchinskaya Inna B.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR168-BR171, il., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Proteinases are widely used in various fields of medicine, such as the treatment of burns, purulent wounds, or decubitus ulcers. On the basis of new microbial proteinases produced by nonpathogenic organisms, a new generation of medical preparations can be developed. Representatives of the Bacillus genera are nonpathogenic and are suitable for producing various proteases in large quantities. B. intermedius is shown to produce a set of alkaline proteases at the early and late stationary phase of growth. The activity of alkaline proteinases was determined using synthetic chromogenous substrates Z-Glu-pNA and Z-Ala-ALa-Leu-pNA. To determine á-galacatosidase aactivity, 2-nitrao-á-D-galactopyranosid was used. Spores were calculated by phase-contrast microscopy. During the late stages of sporulation B. intermedius 3 - 19 cells were shown to secrete two proteinases into the medium: glutamyl endopeptidase, wtih maximum activity at 40 hours of growth, and subtilisin, with maximum activity at 44 hours of growth. Evidence for the secretion of these enzymes into the medium was provided by measuring á-galactosidase activity. Our results show that proteinases from B. intermedius (glutamyl endopeptidase 2 and subtilisin 2) in the late stationary phase of growth are secreted enzymes. This suggests that these enzymes play a role in sporulation.


    468/2523

    Tytuł oryginału: Is the CD14 receptor gene a marker for smoking dependence?
    Autorzy: Hubacek Jaroslv A., Pitha Jan, Skodova Zdena, Poledne Rudolf
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR172-BR174, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The CD14 receptor is a myeloid cell-specific receptor, which plays a role in host defense and cell stimulation. CD14 positive cells have been detected in lung, and also in brain, and the CD14 receptor is thought to play a role in asthma and allergy reactions. C-159 - T polymorphism in the promoter of the CD14 gene has been associated with myocardial infarction, but not in all studies. Our goal was to establish whether this polymorphism is associated with some of the risk factors of MI. With PCR subsequent restriction analysis we evaluated C-159 - T polymorphism in the CD14 gene in 135 representative selecated male Caucasians. We detected a significantly higher frequency of T/T homozygotes (p 0.025) in subjects who had never smoked (15 of 60, 25.0 p.c.) as compared to smokers and past smokers (6 of 75, 8.0 p.c.). The C-159 - T polymorphism in the CD14 gaene could be a genetic marker associated with smoking dependence, but confirmation in large population study is necessary.


    469/2523

    Tytuł oryginału: Blood serum levels of soluble forms of adhesion molecules ICAM-1 (sICAM-1) and selectin E (s-selectin E) in patients with various phases of non-Hodgkin's lymphomas.
    Autorzy: Wołowiec Dariusz, Frydecka Irena, Kapelko-Słowik Katarzyna, Potoczek Stanisław, Urbaniak-Kujda Donata, Kuliczkowski Kazimierz
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR175-BR178, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Monitoring of disease activity and effectiveness of treatment plays an important role in curative management of patients with non-Hodgkin's lymphomas (n-HL). In the search for markers useful for biochemical monitoring of n-HL patients, a group of proteins called adhesion molecules attracted attention. Particular attention has been devoted to sICAM-1 (intercellular adhesion molecule-1). A correlation between sICAM-1 levels and histological malignancy grades and clinical staging of n-HL, activity of the disease and tumor mass has been observed. The aim of the study was to assess the utility of determining serum levels of selected adhesion molecules in n-HL monitoring. The study was carried out in 60 patients with intermediate and high malignancy grade n-HL according to Working Formulation (anaplastic, lymphoblastic, immunoblastic, centroblastic and centroblastic-centrocytic). Soluble ICAM-1 adhesion molecule (sICAM-1) and selectin E levels were determined in the sera of 31 newly diagnosed patients, 18 with complete remission, and 11 with relapse of the disease. The control group consisted of 15 healthy subjects. The results were expressed in ng/ml. sICAM1 levels were similar in healthy controls and patients in the remission phase and significantly lower in patients with diagnosed active disease and relapses. Relapses were associated with slightly lower levels (on borderline of statistical significance) than of diagnosis Serum selectin E levels, however, demonstrated no differences among patient grups or as compared with controls. The presented results indicate the utility of serum sICAM-1 level determination in assessmetn of acaitivty of intermediate and high malignancy grade non-Hodgkin's lymphomas.


    470/2523

    Tytuł oryginału: Immunohistochemical investigations of cathepsin D activity in the structures of cholesteatoma.
    Autorzy: Chodynicki Stanisław, Chyczewski Lech, Olszewska Ewa
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR184-BR186, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Cathepsin D decomposes cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. It takes part in angiogenesis and activates osteoclasts, and is thought to play a major role in the destruction of bone tissue by cholestatoma. The aim of the present study was to evaluate the activity of cathepsin D in the structures of cholesteatoma. Cholesteatomas were collected from 16 patients operated on for chronic inflammation of the middle ear. Specimens were fixed in formalin at pH 7.2, after which parrafin slices were made. Cathepsin D was assayed with a Dako set. Keratin was measured by the Kreyberag method. Normal skin from behind the ear was taken from the patients during the same operation. The samples included a stratified, desquamative epithelium (matrix), a streak containing connective tissue (perimatrix), and a mass of keratin debris. Cathepsin D demonstrates high activity in perimatrix cell adjacent to bone tissue, while it occurs in trace amounts in the matrix. A highly positive reaction was observed within keratin, which was present in the superficial layer of the epithelium. Pseudocathepsin located in desquamative epithelial cells demonstrated a high positive reaction. There were trace amounts of cathepsin D within the dermis. In the control group (the skin samples), there were trace amounts of cathepsin D within the corneous layer of the epithelium. Cathepsin D places a major role in bone tissue destruction due cholesteatoma.


    471/2523

    Tytuł oryginału: Model study of toluene diisocyanate effect on transepithelial ion transport.
    Autorzy: Kosik-Bogacka Danuta Izabela, Tyrakowski Tomasz
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR187-BR192, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Żaby
  • in vitro

    Streszczenie angielskie: Toluene disocyanate (TDI), a low molecular weight compound, is commonly known as a factor causing asthma in chemical industry workers. The present study investigated a possible effect of TDI on ion transport using electrophysiological methods aimed at assessment of ion currents occurring in epithelial tissues. The experiemnts were carried out on 119 fragments of isolated frog skin, sampled from 59 specimens of hybrid frog Rana esculenta L. The procedures employed involved transepithelial electrical potential (PD in mV) measuremetn with an Ussing apparatus, modified to enable mechanical stimulation of organs and defined pharmacological actions. Incubation was carried out using Ringer solution and Ringer solution with amiloride and baumetanide. Direct actions of toluene diisocyanate (TDI) were assessed at the time of administering this substance to the Ussing chamber with a peristaltic pump. Based on the model of frog skin tested with Ussing apparatus, administration of TDI to the fluid stimulating preparations incubated with Ringer solution (RH) and with amiloride (AMI) was demonstrated to cause a hyperpolarization invrease after mechanical stimulation. TDI action on isolated frog skin inflicated a change in response to mechanical stimulation, leading to a depolarization. The reaction magnitude of frog skin incubated with bumetanide (BUME) did not chane due to TDI. TDI influences precesses of sodium ion transport in the isolated frog skin model, depending on mechanical stimulation. This indicates that TDI effect on ion transport in epithelial cells depends on C fibres and tachaykinins released from their endings.


    472/2523

    Tytuł oryginału: Relationship of the BCR gene breakpoint and the type of BCR/ABL transcript to clinical course, prognostic indexes and survival in patients with chronic myeloid leukemia.
    Autorzy: Prejzner Witold
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR193-BR197, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Chronic myeloid leukemia is characterized by the presence of the Philadelphia chromosome. At the molecular level a fusion of part of the ABL and BCR genes is observed. The breakpoint locations in the BCR gene fall between exons b2a2 or b3a2 (5' and 3', respectively). Depending on the BCR gene breakpoint two types of mRNA are created. Differences in the types of transcripts and/or the breakpoint site may have an influence on the clinical course of the disease. This prompted the present author to separate subtypes of chronic myeloid leukemia on the molecular level. 71 patients diagnosed with chronic myeloid leukemia in the chronic phase were enrolled in the study. In 61 patients the type of BCR/ABL transcript was determined, and in 27 patients BCR breakpoints were established. Possible correlations between the clinical coaurse, prognostic indexes, survival and the type of transcript and breakpoint were examined. No correlation between the clinical course, prognostic index, or survival was observed in patients with 5' and 3' breakpoints. The patients with b3a2 transcript experienced longer survival than the patients expressing b2a2 transcript. However, no significant differences were observed in the duration of the chronic phase between the two groups. The type of BCR gene breakpoint seems to have no prognostic value in patients with chronic myeloid leukemia. The longer survival of patients expressing the b3a2 transcript may be caused by the less aggressive course of the accelerated or blastic phase.


    473/2523

    Tytuł oryginału: Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction - data from The Third National Health and Nutrition Examination Survey.
    Autorzy: Qureshi Adnan I., Giles Wayne H., Croft Janet B., Guterman Lee R., Hopkins L. Nelson
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR311-CR316, tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • in vitro

    Streszczenie angielskie: The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined. We evaluated the association between plasma concentrations of APO A-1 and APO B with a physician diagnosis of stroke (n = 153), and electrocardiogram evidence or physician diagnosis of myocardial infarction (n = 379), in a nationally representative sample of 3,696 US adults aged ň 40 years who participated in the Third National Health and Nutrition Examiantion Survey. Multivariate logistic regression analyses were used to investigate these realtionships. After adjusting for differences in age, gender, race/ethnicity, education, hypertension, cholesterol, body mass index, and cigarette smoking, the upper quartile of APO A-1 (ň 161 mg/dl) when compared with the lowest quartile ( 126 mg/dl) was inversely associated with the likelihood of myocardial infarciton (Odds Ratio [OR], 0.6; 95 p.c. Confidence Interval [CI] 0.4 - 0.9) but not stroke. APO B concentrations were not associated with either myocardial infarction or stroke. However, an APO A-1 to B ratio ň 1.59 when compared wtih a ratio ó 1.04 was associated with a decreased likelihood of myocardial infarction (OR, 0.3; 95 p.c. Cl, 0.2 - 0.6); and stroke (OR 0.4, 95 p.c. Cl, 0.2 - 1.0). Higher APO A-1 concentrations were associate with a decreased likelihood for myocardial infarction but not for stroke. The APO A-1 to B ratio was inversely associated with both myocardial infarction and stroke and may be an important protective clinical marker for atherosclerosis.


    474/2523

    Tytuł oryginału: Prevalence of significant carotid artery stenosis in patients with transient ischaemic attack.
    Autorzy: Rappeport Yael, Simonsen Lene, Christensen Hanne, Boysen Gudrun
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR317-CR320, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Carotid artery stenosis is one of the risk factors for transient ischaemic attack (TIA) and stroke. The purpose of this study was to investigate the prevalence of carotid artery stenosis and the prevalence of candidates for carotid endarterectomy in a hospital-based cohort of TIA patients under 71 years of age. This retrospective study included 205 patients with TIA admitted to an acute stroke unit. A carotid Doppler sonography was performed in 114 patients with TIAs in the internal carotid artery territory and a mean age of 60 years. Based on Doppler examinations, the patients were divided into 4 groups according to the following degrees of stenosis: 40 - 59 p.c., 60 - 79 p.c., 80 - 99 p.c. stenosis, and occlusion. Doppler examinations showed that 5 p.c. had a 40 - 59 p.c. stenosis, 5 p.c. had stenosis 60 p.c. and 4 p.c. had occlusion of the relevant internal carotid artery. Carotid endarterectomy was done in 2 p.c. of the patients. Carotid artery stenosis was associated with a history of angina pectoris and myocardial infarction in univariate analysis, but not in multivariate analysis. The prevalence of significant carotid artery stenosis on the relevant side in patients with TIA was quite low: only 5 p.c. had a degree of stenosis where carotid endarterectomy should be considered. Only 2 p.c. eventually had carotid endarterectomy.


    475/2523

    Tytuł oryginału: Heart rate response profiles to tilting in healthy and unhealthy neonates.
    Autorzy: Massin Martial M., Maeyns Kristel, Lombet Jacques, Rigo Jacques, Gerard Paul
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR321-CR325, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Clinical observations suggest the immaturity of the neonate's ability to respond appropriately to cardio-respiratory challenges and tilt test could help in detecating autonomic dysfunction in neonates. Heart rate (HR) responses following a 45ř head-up tilt during sleep were measured within the first week of adjusted age in 7 healthy full-term neonates, 7 healthy preterm infants and 5 neonates with absence syndrome. The tilt and the return to the horizontal position generally provoked a sustained or transient tachycardia, or a flat response in healthy full-term neonates and in preterm neonates, but a sustained or transient bradycardia in neonates with abstinence syndrome. When compared to previous studies in older infants, our data point to the immaturity of the neonate's ability to respond appropriately to cardio-respiratory challenges. No difference is noted between full-term and preterm neonates. The altered HR response in neonates with abstinence syndrome suggests an autonomic dysregulation in this group.


    476/2523

    Tytuł oryginału: Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps.
    Autorzy: Roffe Christine, Sills Sheila, Crome Peter, Jones Peter
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR326-CR330, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Nocturnal leg cramps are common and distressing. The only treatment of proven effectiveness is quinine, but this has a number of side effects. Magnesium salts have been shown to reduce leg cramp distress in pregnancy. This study tests whether magnesium citrate is effective in the treatment of leg cramps in non-pregnant individuals by conducting in a randomised, double-blind, cross-over placebo-controlled trial. Volunteers suffering regular leg cramps were recruited. Magnesium citrate equivalent to 300 mg magnesium and matching placebo were given for 6 weeks each. The number of cramps recorded in the cramp diary during the final 4 weeks of magnesium and placebo treatment, severity and duration of cramps and the participants' subjective assessment of effectiveness were analysed. In subjects who started with placebo (n = 29) the median (95 p.c. CI) number of cramps was 9 (6-17) on placebo and 5 (4-8) on magnesium. For the group starting with magnesium (n = 17) the median no of cramps was 9 (5-13) on magnesium and 8 (4-14) on placebo. The was no significant carry-over effect (p = 0.88), but a highly significant period effect (p = 0.008). There was a trend towards less cramps on magnesium (p = 0.07). There was no difference in cramp severity and duration between the groups. Significantly more subjects thought that the treatment had helped after magnesium than after placebo 36 (78 p.c.) and 25 (54 p.c.) respectively, (p = 0.03). Diarrhoea was recorded as a side effect of magnesium.


    477/2523

    Tytuł oryginału: Prevalence of sleep disturbances in Chinese patients with End Stage Renal Failure on maintenance hemodialysis.
    Autorzy: Hui David SC, Wong Teresa YH, Li Thomas ST, Ko Fanny WS, Choy Dominic KL, Szeto Cheuk C, Lui Siu F, Li Philip KT
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR331-CR336, tab., bibliogr. 41 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Sleep disorders, such as daytime sleepiness, insomnia, restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) have been reported as prevalent among patients with end age renal failure (ESRF). As there is little published data from Southeast Asia, a sleep questionnaire was administered to all patients (N = 43, 27 males) on chronic hemodialysis (HD) at the Prince of Wales Hospital, Hong Kong, to assess their sleep complaints. The mean age was 49.5 ń 11.3 years (mean ń SD) with mean body mass index (BMI) of 22.6 ń 3.6 kg/mý. Frequent awakenings and sleep onset insomnia were the most frequent complaints (79 p.c. each), while daytime sleepines occurred in 74 p.c. of patients. Sleep maintenance insomnia and pruritus occurred in 64 p.c. and 60 p.c. of patients respectively. Symptoms of RLS were reported by 70 p.c. of patients. The prevalence OSAS was estimated by the frequency of observed choking (4.7 p.c. of cases), witnessed apnea (14 p.c.), snoring and witnessed apnea (9.3 p.c.), disruptive snoring (1f4 p.c.), disruptive snoring and witnessed apnea (2.3 p.c.), extremely loud snoring (4.7 p.c.). Our questionnaire survey related a hisgh prevalence of sleep complaints such as frequent awakenings, daytime sleepiness, insomnia and RLS in patients with ESRF on maintenance HD, but a relatively low prevalence of OBAS, which may bea related to the low BMI of our ESRF patients.


    478/2523

    Tytuł oryginału: Lack of association of G-protein subunit gene C825T polymorphism with left ventrucular hypertrophy in essential hypertension.
    Autorzy: Shlyakhto Eugene V., Shwartz Eugene I., Nefedova Yulia B., Zukova Anna V., Vinnic Tatyana A., Konrady Alexandra O.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR337-CR340, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the present study was to determine if there is an association of G-protein á3 subunit (GNB3) gene polymorphisms and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in a St. Petersburg population. We examined 135 patients (mean age 48 ń 7 yrs) with mild to moderate EH recruited from the general population of an outpatient hypertension clinic. Left ventricular mass was measured by echocardiography, and the left ventricular mass index (LVM) was calculated. The GNB3 C825T genotype was determined by polymerase chain reaction and restriction digestion. 67 patients (50 p.c.) were homozygous for the C allele (CC), 56 were heterozygous (CT) (41 p.c.) and twelve (9 p.c.) were homozygous for the T allele (TT). THe distribution of genotypes among the patients was in Hardy-Weinberg equilibrium and did not differ significantly when comparing patients with or without LVH. The frequency of the T allele was only slightly higher in patients with LVH (32 p.c.) compared to those without LVH (28 p.c.), NS, and the LVMI was similar in patients with the CC, CT and TT genotypes (122.3 ń 29.8; 118.8 ń 29.9 and 115.2 ń 18.3 g/mý, respectively). No significant discrepancies were found among the various genotype groups in posterior wall thickness, interventricular septum thickness, or functional parameters such as ejection fraction, isovolumetric relaxation time and E/A ratio.


    479/2523

    Tytuł oryginału: Carboxy terminal domain of the largest subunit of RNA polymerase II of Leishmania donovani has an unusually low number of phophorylation sites.
    Autorzy: Dasgupta Arindam, Sharma Shalini, Das Aditi, Sarkar Dwijen, Majumder Hemanta K.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR341-CR350, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The C-terminal domain (CTD) of the largest subunit of RNA polymerase II in higher eukaryotes has an altered form in Leishmania donovani. To determine whether this is a general feature of the kinetoplastida and to investigate the role of this domain in parasitic RNA pol II transcription, we isolated the gene encoding RNA pol II LS (rpol IILS) and analyzed its C-terminal domain. The discreteness observed may be due to a functional constraint delineating parasite from host. The gene for L. donovani rpol IILS was picked up and sequenced. The CTD of L. donovani rpolIILS was purified as a His-tagged recombinant protein and phosphorylated with a crude kinase extract from L. donovani. An immunoblot analysis of the phosphorylated CTD and photo-crosslinked L. donovani nuclear extracts was done using anti-CTD antibody. The L. donovani rpol IILS is encoded by a single-copy gene. Its transcript is matured posttranscriptionally, with the mini-exon trans-spliced 397 bases upstream of the initiation site. The uniqueness of Leishmania rpol IILS CTD according to prediction analysis was corroborated with in vitro phosphorylation of the recombinant protein. Photoaffinity labelling of L. donovani nuclear run-on transcripts and immunoblot analysis using anti-CTD antibody could identify the active form of RNA polymerase II enzyme in this parasite. The L. donovani rpol IILS possesses a unique C-terminal extension lacking the characteristic repeats but containing serine residues as a potential phosphorylation site. Anti-CTD antiabody could recognize a single molecular species for the RNA pol II enzyme in L. donovani.


    480/2523

    Tytuł oryginału: QT interval in normal infants during sleep with concurrent evaluation of QT correction formulae.
    Autorzy: Benatar Avram, Ramet Jose, Decraene Tine, Vandenplas Yvan
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR351-CR356, il., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: Physiological changes in the QT interval caused by sleep are important in the evaluation of the normal QT interval. Traditionally, Bazett's formula is used for correcting the QT interval for heart rate in childhood. We set out to establish the QT-RR relationship in infants during sleep and concurrently test the performance of four QT correction formulae to determine their comparability and clinical utility. 130 healthy term aborn infants undergoing routine 8-hour polysomnography were enrolled. Continuous EKG limb lead II recording, saturation monitoring, and electroencephalography were conducted. QT intervals and heart rate were measured manually digitally on-screen at hourly intervals. The QT-RR relationship was plotted and QTc calculated using the Bazett, Hodges, Fridericia and Framingham formulae. QTc values for each formula were plotted against age and RR interval. Analysis of variance and regression analysis were used to compare the four formulae and the QT-RR relationship. Mean age was 17.7 weeks (range 4 - 72) and mean weight 6.3 kg (range 2.68 - 12.7). The QT-RR relationship during sleep is curvilinear and appears to be slightly shifted. With increasing heart rate and younger age the Bazett and Hodges formulae overcorrect the QTc whereas the Fridericia and Framingham formulae undercorrect. The Hodges formula correlated best with the RR interval. These formulae are strongly dependent on heart rate. In the setting of a vorderline QTc Bazett prolongation, Hodges formula may be a useful adjunct. Normal infants may have a slightly longer QTc Bazett during sleep.


    481/2523

    Tytuł oryginału: The impact of very late revascularization of occluded infarct-related artery on cardiac mortality and the incidence of sudden death in survivors of acute myocardial infarction - long-term observation.
    Autorzy: Ruta Jan, Bolińska Halina, Ptaszyński Paweł, Rosiak Marcin, Wranicz Krzysztof Jerzy, Kośmider Maciej, Jaszewski Ryszard, Zasłonka Janusz
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR364-CR370, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In survivors of acute myocardial infarction (AMI), an occluded infarct-related artery (IRA) is an important predictor of cardiac death (CD) and sudden death (SD). Early reperfusion of the IRA was associated with improved survival rate. The purpose of the present study was to assess if late IRA revascularization, performed 10 - 30 days after AMI, also has a beneficial effect on the incidence of CD and SD during an 18-month follow-up. The study population consisted of 93 post-MI patients with occluded IRA on coronary angiography. The patients were divided into 2 groups accaording to IRA status at discharge - revascularized (47 patients) or occluded (46 patients) - adn followed. Before revascularization, the two groups of patients did not differ in the prevalence of clinical and angiographic variables, or in the incidence of risk factors for SD. In patients who underwent angioplasty or bypass graft surgery of closed IRA, the markers of electrical instabiality demonstrated no significant improvement after revascularization. During the 18-month follow-up a significantly lower incidence of CD (0 p.c. vs 15 p.c., p 0.01) and SD (0 p.c. vs 11 p.c., p 0.03) was observed in the group of patients with revascularized IRA than in the gorup of patients with occluded IRA. In survivors of AMI, late reperfusion of occluded IRA is associated with reduced 18-month cariac mortality. The beneficial effect of this procedure on the incidence of sudden death, not associated with improvement in myocardial electricall stability, suggests that ischemia can bae considered an important factor modulating the arrythmogenic substrate.


    482/2523

    Tytuł oryginału: Post-traumatic plasminogenesis in intraarticular exudate in the knee joint.
    Autorzy: Rość Danuta, Powierza Wojciech, Zastawna Ewa, Drewniak Wanda, Michalski Arkadiusz, Kotschy Maria
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR371-CR378, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Intraarticular exudate, observed in the knee joint a few weeks after a traumatic incident, is on of post-traumatic complications. Evacuation of the exudate prevents damage of the articular cartilage bay the fluid possessing potent proteolytic properties. In view of the lack of data concerning the role of the fibrinolysis system in proteolytic destructive processes induced by the exudate, the aim of the study was to find out whether plasmin is present in the post-plasmatic intraarticular exudate and whether it is generated in connection with excessive plasminogen activator levels or deficiency of plasminogen activator inhibitors in the synovial fluid. 55 patients (mean age 356. l), with history of knee joint traumas and exudate appearing in the joint at least 3 weeks post-traumatically. The patients and 30 healthy controls were subjected to the following tests of the synovial fluid and plasma: the levels of tissue plasminogen activator, type 1 plasminogen activator inhibitor, plasmin-alpha2-antiplasmin complexes, fibrinogen and von Willebrand factor antigen, the activity of urokinase plasminogen activator, prekalikrein, alpha-2-antiplasmin, C1 inhibitor, type 1 plasminogen activator inhibitor, euglobulin clot lysis time. The patient's plasma demonstrated significantly higher levels of fibrinogen and PAP complexes, and decreased u-PA activity in comparison in that obtained from the controls. Significantly higher levels of PAP complexes and u-PA antigen were found in the exudate than in the patients' plasma. Local, intraarticular plasmin generation, probably u-PA-dependent, occurs in knee joint exudate. Plasminogen activator inhibitors are probable not very closely associated with increased intraarticular plasminogenesis.


    483/2523

    Tytuł oryginału: Hepatitis B vaccine immunogenicity in patients with chronic HCV infection at one year follow-up: the effect of interferon-alpha therapy.
    Autorzy: Chlabicz Sławomir, Grzeszczuk Anna, Łapiński Tadeusz Wojciech
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR379-CR383, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Patients with chronic hepatitis C are at risk of additional liver damage when infected with other hepatotropic viruses, and should be vaccinated against HAV and HBV. However, the optimal dose and schedule are still being debated. In this study we assessed hepatitis B vaccine immunogenicity in patients with chronic hepatitis C at one-year follow-up. The effect of interferon alpha treatment on vaccine safety and anti-HBs response was also evaluated. 48 hepatitis C patients were enrolled, of whom 12 were on interferon treatment. Recombinant HBV vaccine was administered on a 0-1-6 month schedule, and anti-HBs titers were measured at months 1, 2, 7, and 18. The overall seroprotection rate at month 7 was 72.9 p.c. in hepatitis C patients, compared to 90.9 p.c. in the controls. Subjects with chronic hepatitis C had significantly lower percentages of good responders: 50 p.c. versus 90.9 p.c. At month 18, only 34.1 p.c. of the HCV patients had seroprotective titers of anti-HBs, compared to 90 p.c. in the control gorup. At all study points there were no significant differences in seroconversion rates and seroprotection rates between subgroups of hepatitic C patients receiving interferon or those without antiviral treatment. Hepatitis C is associated with decreased HBV vaccine response. We suggest that postvaccination anti-HBs testing should be performed in all hepatitis C patients, and additional vaccine doses should be provided to those without protection. Alternatively, higher doses of vaccine (40 ćg) may be considered. Treatment with interferon was safe and well tolerated.


    484/2523

    Tytuł oryginału: Flu-like response on statins.
    Autorzy: Sinzinger Helmut
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR384-CR388, tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Stains became one of the most widely used family of drugs meanwhile. Myopathy in various forms is among the most prevalent side effects. Only few attention has been paid to its various forms of appearance. We are reporting on a so far unknown flu-like response on statins with very severe symptoms of exhaustion, wekness, paining muscles and joints elevated acute phase response markers and sometimes even subfebrile body temperature. The 5 patients (4 males, 1 female) we monitored showed this response to some but not all the available statins with an onset of latest 3 weeks after strating therapy. Symptoms appeared already at the lowest available dose of the respective statin. Only in 3 of the patients, CK-elevation was noted, while 4 of them exahibited a severe increase in 8-epiprostaglandin-F2a, an in-vivo oxidation injury marker. Latest 5 weeks after statin withdrawal the symptoms completely disappeared. Liver function parameters remained normal in all the patients at all time. Misinterpretation of this flu-like response is particularly dangerous as the treatment with antibiotics initiated in one of the patients may have had deleterious consequence. The pathophysiological background of this response remains to be asessed.


    485/2523

    Tytuł oryginału: The Prozac boom and its placebogenic counterpart - a culturally fashioned phenomenon.
    Autorzy: Slingsby Brian Taylor
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR389-CR393, bibliogr. 46 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The placebo effect describes the mind-body process of altering the body's physiological state as well as the brain's neurological state. Catalyzed by the mind's believing in a certain drug, ritual, and/or treatment, it generally referes to the phenomenon of an ill individual recovering to health. Subsequent to the Prozac boom (fluoxetine), which occurred during the 1980s and 90s in the United States, a new form of placebogenic phenomena was defined: 'cosmetic psychopharmacology', whereby the healthy individual is transformed to fit better in his/her cultural medium (defined by one's values and beliefs). In order to discover how cultural metaphors (e.g. media-generated symbolism, social ideals) influence psychopharmacological treatment, this report investigates the following questions: Is the Prozac Boom culturally fashioned? Is cosmetic psychopharmacology culturally fashioned? Are cosmetic psychopharmacology and its ability to better the individual (relative to American ideals) a placebogenic phenomenon? The data and speculation for the present report was obtained via a cultural and ciritcal review. It would appear that (1) the Prozac Boom and subsequently its by product, cosmetic psychopharmacology, are culturally fashioned; (F2) cosmetic psychopharmacology is considered to result from one's belief in a drug and thus is placebo-influenced. Media-generated symbolism, which represents and reciprocally fashions the ideals and values of that society, influence the social perceptions of a drug's effectiveness and the quality of a particular treatment. In the clinical setting, the infuential roel of these preconceived notions abaout a certain treatment and/or drug need to be further considere and studied.


    486/2523

    Tytuł oryginału: Infertility status of male individuals with abnormal spermiogram evaluated by cytogenetic analysis and in vitro sperm penetration assay.
    Autorzy: Wiland Ewa, Wojda Alina, Kamieniczna Marzena, Szczygieł Monika, Kurpisz Maciej
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR394-CR400, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The possibility of a link between altered sperm morphology and functional ability, possibly reflected on the genetic level, is still a matter of controversy. 60 infertile males with pathological spermiogram and 14 healthy individuals with confirmed in vivo fertility were selected for our study. Ejaculated sperm was assessed according to the standard criteria set by the World Health Organization, which constituted a basis for subgroup classification. The sperm penetration assay (SPA) using human sperm and hamster oocytes was subsequently performed with concomitant cytogenetic analysis of peripheral blood leukocytes (PBL). More than 55 p.c. of infertile males with pathological spermiogram exhibited a decreased ability for penetration of the oocyte (SPA ó 30 p.c.). The lowest penetration ability was observed in the semen of patients with oligoasthenoteratozoospermia (OAT), of whom as many as 75 p.c. presented negative SPA values. We noted only 1 case of chromosome aberration (Robertsonian translocation) in the analyzed cohort of infertile patients. Strikingly, in the identified group of infertile patients with chromosome structural polymorphism (acrocentric chromosomes), we revealed a statistically significant decreased rate of sperm - oocyt penetration. A causative link may exist between sperm malfunction and a specific feature of the chromosome variants detected in the blood leukocytes of infertile males with pathological spermiogram.


    487/2523

    Tytuł oryginału: Effect of combined dopamine and diltiazem on renal function after cardiac surgery.
    Autorzy: Yavuz Senol, Ayabakan Nurcan, Goncu M. Tugrul, Ozdemir I. Ayhan
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.PI45-PI60, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • farmacja
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In order to evaluate the effect of the combined use of dopamine and diltiazem on renal function in patients undergoing coronary artery bypass grafting (CABG), we conducted a prospective randomized study. Sixty patients (8F, 52M) with normal preoperative renal function undergoing CABG were divided randomly into four groups, including control (n = 15), use of dopamine-only (n = 15), use of diltiazem-only (n = 15), and combined use of dopamine and diltiazem (n = 15). The patients ranged in age from 38 to 74 years (mean 59.3). Drug administration (diltizem: intravenous infusion of 2 ćg kg-1.min-1, dopamine: 2 ćgúkg-1.min-1) was initiated 24 hours before surgery and was continued for 72 hours. Creatinine and osmotic clearances were found to be significantly higher in the combined group compared with the other groups 24 hours after surgery (p 0.05). There was no significant difference in respect to creatinine clearance, osmotic clearance, and free water clearance in the dopamine-only and diltiazem-only groups compared to the control group. The free water clearance at 24 and 72 hours after surgery were significantly higher in the combined group compared with the other groups (p 0.05). In the control group, dopamine-only, and diltiazem-only groups á2-microglobulin was statistically higher 72 hours postoperatiave than preoperatively (p 0.050). There were no significant changes in á2-microglobulin levels in the combined group. The combined use of dopamine and diltiazem may provide a positive contribution and sufficient protection for early postoperative renal function in patients undergoing CABG.


    488/2523

    Tytuł oryginału: Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy.
    Autorzy: Noutsias Michel, Pauschinger Matthias, Ostermann Karsten, Escher Felicitas, Blohm Jan-Henrik, Schultheiss Heinz-Peter, Khl Uwe
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.MT59-MT71, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We attempted to develop a digital image analysis (DIA) system for endomyocardial biopsies (EMBs) to reliably quantify a) biopsy quality, b) immunohistochemically-marked infiltrates, and c) cell adhesion molecules (CAMs) in relation to net heart area (HA) for the semi-automated diagnosis of inflammatory cardiomyopathy (InfCM). 140 EMBs from dilated cardiomyopathy (DCM) patients and 14 autopsy heart samples (controls) were immunostained for T-lymphocytes (CD2, CD3, CD4, CD8), á2-integrin + infiltrates (CD18, LFA-1, Mac-1) and CAMs (immunoglobulin superfamily: ICAM-1, HLA class I, HLA DR, VCAM-1, CD58; selectins: CD62E and CD62P; and the á1-integrin chain CD29). EMB quality was assessed visually on a three-point scale. Infiltrates were quantified visually (per hpf) and by DIA (per mm2 HA). CAM expression was evaluated semiquantitatively and bay DIA (area fraction [AF]: stained area relative to HA). DIA-evaluated HA correlated significantly with the visual assessment of EMB quality. The visual evaluation of both infiltrates and CAMs correlated significantly with the respective DIA-based quantification. DIA-quantified CAM-AF and infiltrates were discriminated bay the CAM clssification (CAMs+: n = 87; 62 p.c.) compared to controls. DIA-quantified cCAM immunoreacativity correlated significantly with the DIA-quantified counter-receptor + infiltrates. DIA evaluation of biopsy quality, infiltrates, and CAMs was devoid of inter- and intraobserver variability. The DIA system presented here enables standardized and observer-independent assessment of EMB quality and intramyocardial...


    489/2523

    Tytuł oryginału: Significance of ultrasound vaginal cervicometry in predicting preterm delivery.
    Autorzy: Mara Michal, Calda Pavel, Haakova Lucie, Zizka Zdenek, Dohnalova Anna, Zivny Jaroslav
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.MT72-MT77, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: The objective of the study was to verify whether ultrasound vaginal cervicometry, performed in the 18th - 20th week of gestation, can effectively predict preterm delivery. 279 singleton pregnancies were prospectively studied from the middle of gestation until delivery. In the 18th - 20th week of gestation we performed ultrasound vaginal cervicometry, which we used to determine the length of the cervix, judge the shape of the internal os, and evaluate the cerviacometry as normal or abnormal on the basis of these parameters. With the aid of onedimensional and multi-dimensional analysis, we tested the dependence of completed weeks of gestation and preterm delivery on the results of ultrasound cervicometry. 247 women completed the study. Cervicometry was evaluated as abnormal in 53 women (21.46 p.c.). We proved a significant dependence of delivery prior to the 34th week of gestation on cervical length (p 0.01), abnormal shape of the internal os (p 0.0001; RR = 10.35), and abnormal cervicometric result (p 0.0001; RR = 29.28). Delivery prior to the 37th week was also significantly dependent on all observed parameters. Of the individual cervicometric parameters, cervical length had the most significant impact on the completed weeks of gestation. The implementation of ultrasound vaginal cervicometry in the prenatal screening program can lead to effective and early selection of women with a significantly increased risk of preterm delivery.


    490/2523

    Tytuł oryginału: Embryonic stem cell research: the relevance of ethics in the progress of science.
    Autorzy: Ruiz-Canela Miguel
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.SR21-SR26, il., bibliogr. 50 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód

    Streszczenie angielskie: Experimentation with embryonic stem (ES) cells has become an important breakthrough in medical research. However, it is also a source of controversy, because it requires the destruction of the human embryos used to derive ES cells. This paper deals with some of the ethical issues concerning ES cell research. To begin with, the terms used in the debate on the wthical status of the human embryo need to be defined. Apart form the presumed benefits of ES cell research, we should also consider such issues as the strong opposition to this reseach by a large part of society, who argue in favour of protecting and respecting human embryos; the fragility and defenseless of human embryos; and the contradiction in terms inherent in the statement that human embryos must be treated with respect. Secondly, we should focus on possible conflicts between the financial, scentific, and ethical aspects of this debate. Thirdly, the significance of social and political debate requires clear and complete information that takes all consequences into account. Finally, the paper suggests how multipotent adult stem cell research may be an optimal and realistic alternative to ES cell research.


    491/2523

    Tytuł oryginału: Stress in cardiovascular diseases.
    Autorzy: Esch Tobias, Stefano George B., Fricchione Gregory L., Benson Herbert
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.RA93-RA101, il., bibliogr. 85 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Evidence for a connection between stress and selected cardiovascular diseases is analyzed. Does stress cause or exacerbate cardiovascular diseases? The stress phenomenon is illustrated and the impact of stress on the circulatory system is examined. In particular, the pathophysiological significance of stress in hypertension, atherosclerosis, coronary artery disease, myocardial infarction (and others) is described. Stress plays a major role in various (pathophysiological processes associated with the circulatory system. Thereby, it potentially has ameliorating or detrimental capacities. However, with regard to cardiovascular disease, stress most often is related to deleterious results. The specific outcome depends on multiple variables (amount of stress, duration of is influence, patient's history/predisposition, genetic components - as they all may after functions of the basic stress response components: the hypothalmic-pituitary-adrenal axis and the sympathoadrenal medullary system). Stress has a major impact upon the circulatory system. It plays a significant role in susceptibility, progess, and outcome of cardiovascular diseases. Subjective or individual differences have also to abe taken into account. Stress, especially 'adequate'acute stress - stress that is not 'overwhelming' - may improve performance and thus be beneficial in certain cases. The close relationship between stress and cardiovascular diseases may represent an important aspect of modern medicine. New therapeutic strategies have to be set in place.


    492/2523

    Tytuł oryginału: Coronary artery calcification and carotid intima-media thickness in ischaemic heart disease.
    Tytuł polski: Choroba niedokrwienna serca. Wskaźnik uwapnienia tętnic wieńcowych i grubość kompleksu intima-media.
    Autorzy: Kabłak-Ziembicka Anna, Pasowicz Mieczysław, Konieczyńska Małgorzata, Przewłocki Tadeusz, Klimeczek Piotr, Pieculewicz Monika, Tracz Wiesława
    Opracowanie edytorskie: Szwed Hanna (koment.), Pruszyński Bogdan (koment.).
    Źródło: Kardiol. Pol. 2002: 57 (8) s.83-95, il., tab. - Tekst. równol. w jęz. pol.
    Sygnatura GBL: 313,397

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background. Coronary angiography is the reference standard in detection of coronary artery disease (CAD). Exercise testing and stress echocardiography have been used for selection of patients who should undergo coronary angiography, however, sensitivity and specifity of these methods are limited. Recently, new non-invasive methods such as multidetector spiral computed tomography (MSCT) and carotid artery ultrasonography have been introduced in the evaluation of CAD. Aim. To examine the usefulness of coronary calcium scoring (CS) and carotid intima-media thickness (IMT) in the assessment of the extent of CAD. Methods. The study group consisted of 100 patients (mean age 59 ń 9.4 years, range 43-79 years) with a clinical diagnosis of CAD. All patients underwent coronary angiography as well as carotid Doppler ultrasoung for IMT measurement and MSCT for coronary artery calcification evaluation. Results. Significant positive correlations between age and CS as well as IMT values were found (p=0.0001, r=0.385; and p=0.0000, r=0.486, respectively). The IMT values significantly correlated with the number of coronary lesions and were significantly higher in patients with two-vessel or three-vessel CAD than in patients with normal coronaryy angiography (p=0.0530 and p = 0.0009, respectively). All patients with the CS values 400 had significant CAD, including 56 p.c. of patients with a three-vessel CAD There was a positive correlation between IMT and CS (p=0.0000, r=0.506). Sensitivity and specifity of IMT and CS detecting CAD were 84 p.c. an 58.8 p.c. for for IMT, and 57 p.c. and 100 p.c. for CS, respectively.


    493/2523

    Tytuł oryginału: Coronary flow reserve measured by stress transesophageal echocardiography in hypertrophic cardiomyopathy with subvalvular gradient.
    Tytuł polski: Ocena rezerwy przepływu wieńcowego przy pomocy echokardiografii przezprzepływowej u chorych z kardiomiopatią przerostową z gradientem podzastawkowym.
    Autorzy: Nemes Attila, Forster Tamas, Palinkas Attila, H”gye Marta, Csanady Miklos
    Źródło: Kardiol. Pol. 2002: 57 (8) s.96-101, tab., bibliogr. 34 poz., streszcz. - 23 Kongres Europejskiego Towarzystwa Kardiologicznego Sztokholm 2001
    Sygnatura GBL: 313,397

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp. Rezerwa przepływu wieńcowego (CRF) jest zmniejszona u niektórych chorych z kardiomiopatią przerostową (HCM). Jedną z nowszych nieinwazyjnych metod pozwalających na ocenę CRF jest echokardiografia przezprzełykowa. Cel. Porównanie wielkości CRF u chorych z HCM w zależności od występowania gradientu podzastawkowego. Metodyka. Prędkość przepływu rozkurczowego była mierzona w warunkach podstawowych i po badaniu leku rozkurczającego naczynia wieńcowe - dipyridamolu. Lek podawano w dawce 0.56 mg/kg w ciągu 4 minut, a szczytowa prędkość przepływu mierzona po 6 minutach CRF obliczano jako stosunek prędkości szczytowego i podstawowego przepływu rozkurczowego. W badaniu wzięło udział 19 chorych z HCM oraz 24 chorych z prawidłowym wynikiem koronarografii, stanowiących grupę kontrolną. Wyniki: U wszystkich chorych z HCM przerost dotyczył przegrody międzykomorowej (średnia grubość 20.7 ń 3.7 mm). U 6 chorych obserwowano skurczowy ruch przedniego płatka zastawki mitralnej, a gradient podzastawkowy wynosił średnio 38.7 ń 16.3 mmHg (zakres od 27 do 67 mmHg). U 3 chorych nie rejestrowano prędkości skurczowego przepływu wieńcowego w warunkach podstawowych, a jedynie po podaniu dipyridamolu. U pozostałych 3 chorych z tej grupy rejestrowano wstęczny przepływ skurczowy, który nie zmieniał sięe po podaniu leku. Średnia wartość CRF u chorych z grupy kontrolnej z prawidłowym wynikiem koronarografii wynosiła 3.08 ń 1.08, a u chorych z HCM - 2.14 ń 0.68 (P 0.001). Masa lewej komory ...

    Streszczenie angielskie: Bacground. Coronary flow reserve (CFR) is decreased in some patients with hypertrophic cardiomyopathy (HCM) and may be determined by means of stress transesophageal echocardiography. Aim. To compare the CRF in HCM patients with or without a subvalvular gradient. Methods. Diastolic velocities were measured under baseline conditions and during maximum stress. Dipyridamole was administered as a vasodilator agent in a dose of 0.56 mg/kg over 4 minutes, and peak velocities were measured after 6 minutes. The CRF was calculated as the ratio of the baseline diastolic velocites. Nineteen HCM patients were examined, together with 24 patients with normal coronary angiograms who severed as controls. Results. In all HCM patients, the hypertrophy was studied in the intraventricular septum (mean thickness 20.7 ń 3.7 mm). In 6 patients, systolic anterior motion was observed, and subvalvular gradients were measured (38.7 ń 16.3 mm Hg, range 27-67 mmHg). In 3 patients no systolic velocites were detected under baseline conditions, but only during maximum stress. In another 3 patients there was a reserved systolic flow, which remained unchanged during stress. The CRF in patients with normal coronary angiograms was 3.08 ń 1.08, while in HCM patients - 2.14 ń 0.68 (p 0.001). The left vemntricular mass was significantly higher in the HCM patients than in controls (410.7 ń 112.8 g vs 264 ń 69.4 g, p 0.05). There was a slight dfifference in the CRF between HCM patients with or without a ...


    494/2523

    Tytuł oryginału: Surowce zielarskie w zewnętrznym leczeniu skóry.
    Tytuł angielski: Plant raw materials in external skin therapy.
    Autorzy: Lutomski Jerzy
    Źródło: Wiad. Zielar. 2002: 44 (7) s.4-6, tab.
    Sygnatura GBL: 311,671

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    495/2523

    Tytuł oryginału: Critical overview of the current status of organ donors with primary central nervous system tumors.
    Autorzy: Hałoń Agnieszka, Patrzałek Dariusz, Rabczyński Jerzy
    Źródło: Ann. Transplant. 2002: 7 (1) s.6-14, tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • onkologia
  • transplantologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The transmission of donor-related malignancies by organ transplantation is rare event but biological behaviour of malignant tumors developed by the transplanted patients is in general more agressive than similar ones in non-transplanted population. This paper presents an analysis of our series of cases and a review of the literature to the point of the transmission of cancer from organ donors with primary central nervous system tumors. Patients with primary CNS neoplasms have been accepted for organ donation because these tumors very rarely spread outside the CNS. To our knowledge, after an extensive review of the literature, the CNS tumor transmission risk with transplantation may be estimated between a little more than 0 p.c. and 3 p.c. In the light of available data and in accordance with our investigations we consider that patients with CNS tumors can be accepted as donors as long as the risk of dying on the waiting lists is significantly higher than the tumor transferral risk. Organ donors with benign or low-grade CNS tumor should be accepted unreservedly. Donors with high-grade tumors should be consider as "marginal donors" and their assessment can be based on the comparison and the balance between the risk of tumor transmission and the medical condition of the recipient.


    496/2523

    Tytuł oryginału: Organ donor with cerebellar medulloblastoma: a case report and review of the literature.
    Autorzy: Hałoń Agnieszka, Patrzałek Dariusz, Rabczyński Jerzy
    Źródło: Ann. Transplant. 2002: 7 (1) s.15-19, tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • onkologia
  • transplantologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Transplantation of organs and tissues procured from brain-dead organ donor (BDOD) is nowadays a common and desirable therapy for end-stag organ failure, especially kidneys, liver and heart. The majority of organs for transplantation are obtained from individuals with massive and irreversible central nervous system injury. This group of organ donors is however unsatisfactory and small according to needs. Significant percentage of multiorgan donors could be found among patients suffering from primary cerebral neoplasms as these rarely metastasize spontaneously outside the central nervous system. The paper presents the case of a 30-year-old male donor with a central nervous system tumor. Histogenesis, pathway of malignant dissemintation, prognosis and the use of organ donor with cerebellar medulloblastoma are also discussed.


    497/2523

    Tytuł oryginału: Aneurysm of common and internal iliac arteries 14 years after kidney transplantation - a case report.
    Autorzy: Gałązka Zbigniew, Świercz Paweł, Rongies Witold, Szmidt Jacek
    Źródło: Ann. Transplant. 2002: 7 (1) s.22-24, il., bibliogr. 15 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • kardiologia
  • nefrologia
  • chirurgia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: The aim of the report is to present successful surgical treatment of aneurysm of common iliac artery (CIA) and internal iliac artery (IIA) in a kidney transplant patient. The aneurysm of CIA and IIA, causing arterial hypertension, was diagnosed and treated surgically in a 47-year-old male patient, who had received a cadaveric kidney transplant 14 years before. During the operation, consisting of aorto-femoral unilateral grafting with transplanted kidney artery implantation to the side of the graft and aneurysm exclusion, cold Ringer's lactate perfusion was used to protect the transplanted kidney. There were no postoperative complications; the transplant function is satisfactory in a follow-up of 44 months. Exclusion of CIA and IIA aneurysm using aorto-femoral unilateral graft is an effective way of treatment in kidney transplant patients. The cold perfusion during aortic cross-clamping is an effective and simple method of transplanted kidney protection.


    498/2523

    Tytuł oryginału: From the guest editor.
    Autorzy: Myśliwiec Michał
    Źródło: Ann. Transplant. 2002: 7 (1) s.27, bibliogr. 3 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny


    499/2523

    Tytuł oryginału: Thrombotic microangiopathy in renal transplantation.
    Autorzy: Chiurchiu Carlos, Ruggenenti Piero, Remuzzi Giuseppe
    Źródło: Ann. Transplant. 2002: 7 (1) s.28-33, tab., bibliogr. 76 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • hematologia
  • nefrologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The term thrombotic microangiopathy (TMA) encompasses syndromes of thrombocytopenia, microangiopathic haemolytic anaemia, neurologic deficits, renal dysfunction and variable signs of organ impairment. Childhood cases of TMA with predominant renal failure are usually referred as Haemolytic Uremic Syndrome (HUS), and adult cases with major neurological involvement as Thrombotic Thrombocytophenic Purpura (TTP). Exotoxins, produced in most cases by E. Coli O157:H7, have been related to diarrhea associated HUS(D+HUS). Anticancer (mitomycin), immunosuppressive drugs (cyclosporin, tacrolimus and OKT3) and as well as some antiplatelet agents (ticlopidine, clopidrogel) have been associated with both HUS and TTP. Defective factor H or vWF protese activity have been found familiar and recurrent forms. Endothelial damage and dysfunction is most likely the initial event of the pathogenic process that eventually leads to plateled aggregation, microvascular thrombosis and tissue ischemia. TMA may occur de novo in the native kidneys of patients who received a non-kidney transplant or in the transplanted kidney patients who progressed to ESRD because of a disease other than HUS. Calcineurin inhibitors and vascular rejection are most often involved in these cases. The disease may also recur on the transplanted kidney in patients who progressed to ESRD because of HUS/TTP. The risk of postransplant recurrence is negligible for D + HUS but is close to 100 p.c. in familial/recurrent forms associated with low C3 and decreased factor H bioavailability or activity...


    500/2523

    Tytuł oryginału: Fibrinolysis in chronic renal failure, dialysis and renal transplantation.
    Autorzy: Opatrny K., Zemanova P., Opatrna S., Vit L.
    Źródło: Ann. Transplant. 2002: 7 (1) s.34-43, il., bibliogr. 70 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • nefrologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The best known function of the fibrinolytic system is its ability to dissolve blood clots. The key enzyme of fibrinolysis, plasmin, is formed by conversion from plasminogen through the action of activators, the most important of which is tissue type plasminogen activator (tPA). Low levels of tPA or excessive levels of plasminogen activator inhibitor-I (PAI-I) cause hypofibrinolysis, causally related to the development of atherosclerosis and associated thrombotic complications, as well as with the development of venous and arterial thrombosis. A chronic decrease in renal function leads to hypofibrinolysis due primary to low levels of tPA. Hypofibrinolysis is present both in patients treated by long-term hemodialysis and by peritoneal dialysis. The hemodialysis procedure acutely raises the plasma levels of tPA, primarily as a result of the bioincompatibility of materials in the extracorporeal circuit. In peritoneal dialysis, dialysis solution dwell time is associated with an increase in PAI-I levels in the abdominal cavity. Fibrinolysis defects occur also in renal transplant recipients. In transplant patients, the main abnormality is also hypofibrinolysis which, however, unlike the situation with the other methods of renal replacement therapy, is secondary to a rise in PAI-I. A role in the increase of the plasma levels of PAI-I in transplant patients is played by steroid-and cyclosporine-based immunosuppression, most likely by metabolic disorders such as insulin resistance or dyslipoproteinemia, and by genetic factors. Animal experiments ...


    501/2523

    Tytuł oryginału: The effect of chronic allograft rejection on plasma regulators of fibrinolysis.
    Autorzy: Perkowska A., Elhasade As., Durlik M., Placha G., Gałązka Z., Lao M[ieczysław], Gaciong Z[bigniew]
    Źródło: Ann. Transplant. 2002: 7 (1) s.44-51, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • nefrologia
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Chronic renal allograft rejection is often associated with the presence of fibrin thrombi in the microcirculation. Our purpose was to evaluate the influence of chronic rejection on fibrinolytic regulators in plasma of renal allograft recipients. We evaluated the concentration and activities of tPA, uPA and PAI-I in plasma from kidney allograft recipients. We studied 64 patients who underwent kidney transplantation from cadaveric allograft donors. At the time of the study 38 patients had stable graft function for at least 6 months proceeding the study, and 26 recipients had biopsy-proven chronic rejection of the kidney transplant. Control group included 30 healthy blood donors. In kidney transplant recipients we found significantly higher plasma tPA activity (median: 0.99 IU/ml; range 0-3.8 IU/ml) in comparison to healthy controls (median: 0.15 IU/ml; range: 0-2.8 IU/ml) (p = 0.002) as well as significantly lower plasma PAI-I activity (median: 7.06 U/ml; range 0-33.2 U/ml) in comparison to healthy controls (median: 21.8 U/ml; range: 0-36.7 U/ml), (p = 0,0001). Among transplant recipients, PAI-I plasma activity in recipients with chronic graft rejection (median: 10.16 U/ml; range 0-33.2 U/ml) was significantly higher than in patients with stable graft function (median: 4.83 U/ml; range: 0-22.9 U/ml). In transplant recipients with stable graft function and poorly controlled hypertension we found significantly higher PAI-I plasma activity in comparison to recipients with normal blood pressure (p=0.006). In kidney transplant recipients there was a positive correlation between...


    502/2523

    Tytuł oryginału: Effects of fluvastatin on homocysteine and serum lipids in kidney allograft recipients.
    Autorzy: Małyszko Jolanta, Małyszko Jacek S., Brzósko Szymon, Pawlak Krystyna, Myśliwiec Michał
    Źródło: Ann. Transplant. 2002: 7 (1) s.52-54, il., bibliogr. 18 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Hyperhomocysteinemia is now recognized as an independent risk factor for atherosclerotic cardiovascular disease in patients with normal renal function. Hyperhomocysteinemia is common in patients with chronic renal failure. Kidney transplant recipients have a high risk of cardiovascular death. Recently, attention has been paid to the association between homocysteine and cardiovascular disease. Dyslipidemia is also common in kidney transplant recipients. The purpose of this study was to assess whether fluvastatin in a dose of 20 mg affects homocysteine concentration in 10 stable renal transplant recipients. We evaluated Hcy, lipoprotein (a) by the use of commercially available kits as well as plasma fibrinogen and cholesterol, triglycerides and albumin levels. All the parameters were studied before and after 1,2 and 3 months of fluvastatin treatment. Cholesterol and LDL decreased significantly as early as after I month and remained lowered during the therapy. No significant changes in Hcy, lipoprotein (a) and fibrinogen were found during therapy with fluvastatin. Fluvastatin is an effective hypolipemic agent and has no effect on Hcy and fibrinogen concentration in kidney tranplant recipients.


    503/2523

    Tytuł oryginału: Effects of immunosuppressive drugs on platelet aggregation in vitro.
    Autorzy: Małyszko Jolanta, Małyszko Jacek S., Takada Akikazu, Myśliwiec Michał
    Źródło: Ann. Transplant. 2002: 7 (1) s.55-68, il., bibliogr. 40 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • transplantologia
  • farmacja
  • hematologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Disturbances in platelet functions are found in kidney diseases and may contribute to the progression of atherosclerosis with its thrombotic complications. Kidney allograft recipients are particularly prone to dyslipidemia and have a high risk of cardiovascular death. The purpose of this work was to assess effects of various immunosuppressive drugs on aggregation of platelets obtained from healthy volunteers and chronically hemodialyzed patients. Platelet aggregation in the whole blood and in PRP was induced by collagen (2-ćg/ml whole blood and PRP) arachidonic acid (0.75 mM whole blood and PRP). ADP (10 ćM-whole blood and 5 ćM-PRP), ristocetin (0.75 mg/ml - whole blood and 1.5 mg/ml - PRP) and was studied after preincubation with clinically relevant concentrations of cyclosporine A, FK 506, 15-deoxyspergualin, azathioprine, mizoribine, mycophenolic acid and mycophenolate mofetil. Preincubation with cyclosporine A resulted in a significant increase in platelet aggtegation, whereas preincubation with FK 506, azathioprine, mizoribine, mycophenolic acid and mycophenolate mofetil caused a decrease in platelet aggregation. 15-deoxyspergualin did not affect platelet aggregation. Enhanced plateled aggregation. Enhanced platelet aggregation in CSA-treated kidney allograft recipients may have clinical implications in regard to the reported tendency to thrombosis in those patients, and to CSA-induced nephrotoxicity. Thus, inhibition of platelet activity in these patients might be of clinical benefit.


    504/2523

    Tytuł oryginału: Chronic treatments with haloperidol and clozapine alter the level of NMDA-R1 mRNA in the rat brain: an in situ hybridization study.
    Autorzy: Ossowska Krystyna, Pietraszek Małgorzata, Wardas Jadwiga, Dziedzicka-Wasylewska Marta, Nowicka Dorota, Wolfarth Stanisław
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.1-9, il., bibliogr. 45 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The aim of the present study was to examine the influence of 3-month administration of the typical neuroleptic haloperidol (1 mg/kg/day) and the atypical one clozapine (30 mg/kg/day) on the expression of the NMDA-R1 mRNA in different brain structures using in situ hybridization in rats. A long-term treatment with haloperidol decreased the NMDA-R1 mRNA level in intermediate and caudal parts of the caudate-putamen and in more caudally localized regions of parietal and frontal cortices, but increased it in the CA1 region of the hippocampus. No significant changes in the nucleus accumbens, insular cortex, CA3 and dentate gyrus of the hippocampus were found after haloperidol administration. Clozapine did not influence the NMDA-R1 mRNA expression in the hippocampus, as well as in the intermediate and caudal regions of the caudate-putamen, but significantly increased it in the rostral region of the latter structure, in the nucleus accumbens and insular cortex. The present study suggests that both these neuroleptics influence the expression of the mRNA of the NMDA-R1 subunit in brain structures which are thought to be important for development of psychotic symptoms.


    505/2523

    Tytuł oryginału: Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxia.
    Autorzy: Nadlewska Agnieszka, Car Halina, Oksztel Robert, Wiśniewski Konstanty
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.11-18, il., bibliogr. 38 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: We investigated the effects of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (I mGluRs), on certain behaviors in rats after short-term hypoxia as a model of experimentally induced amnesia. The effect of (S)-3,5-DHPG administered intracerebroventriculary (icv) at doses of 0.01, 0.1 and 1.0 nmol was assessed using behavioral tests: the open field test, the passive avoidance response and the elevated "plus" maze test. (S)-3,5-DHPG did not change the number of crossed fileds and rearings and only at a dose of 0.01 nmol it increased the number of bar approaches in the open field test. (S)-3,5-DHPG used at all doses improved consolidation, and at doses of 0.01 and 1.0 nmol it improved retrieval in the passive avoidance test. (S)-3,5-DHPG did not produce any significant effects in control rats in the elevated "plus" maze test. Hypoxia inhibited locomotor and exploratory activity of rats, significantly impaired consolidation and retrieval processes. We observed tendency to shortening the time spent in open arms and to decrease in the number of entries into open arms in the number of entries into open arms in the elevated "plus" maze in rats with undrewent hypoxia. In hypoxia-treated groups of rats, (S)-3,5-DHPG inhibited locomotor and exploratory activity in comparison with the control groups administered (S)-3,5-DHPG. Hypoxia significantly inhibited beneficial effects of (S)-3,5-DHPG on consolidation and retrieval in passive avoidance. (S)-3,5-DHPG only at the dose of 1.0 nmol used before hypoxia improved consolidation and at the dose of 0.01 nmolenhanced retieval in comparison with saline-treated group subjected to hypoxia...


    506/2523

    Tytuł oryginału: Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies.
    Autorzy: Michaluk Jerzy, Krygowska-Wajs Anna, Karolewicz Beata, Antkiewicz-Michaluk Lucyna
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.19-25, il., tab., bibliogr. 43 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: It is well recognized that 1,2,3,4-tetrahydroisoquinoline (TIQ) is a substance capable of inducing in animals a syndrome, regarded as an animal model of Parkinson's disease. This study was designed to evaluate the effect of the endogenous neruotoxin TIQ on the brain noradrenaline (NA) metabolism in mice and on an arterial blood pressure in rats. It was shown for the first time that TIQ significantly increased NA metabolism, induced NA release and raised the level of its final metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), in mouse brain. The comparative biochemical studies using specific agonist (clonidine) and antagonist (yohimbine) of ŕ2-adrenergic receptors ligands have shown that observed biochemical effects were similar to those produced by ŕ2-adrenergic antagonist, yohimbine. In functional studies, the systolic and diastolic blood pressure was measured using a non-invasive blood pressure transducer. Both acute and multiple treatment with TIQ produced a strong hypotensive effect, haveing decreased both systolic and diastoic blood pressure in rats. Development of tolerance to the hypotensive effect was observed after multiple treatment with TIQ. The data coming from these experimental studies apparently suggest an important role of the noradrenergic system in the mechanism of action of endogenous compounds from TIQ group. The results may also support the hypothesis assuming a causal relationship between noradrenergic dennervation, activity of the nigrostriatal dopamine system, and some clinical manifestation of Parkinson's disease.


    507/2523

    Tytuł oryginału: Role of nitric oxide in benzodiazepines-induced antinociception in mice.
    Autorzy: Talarek Sylwia, Fidecka Sylwia
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.27-34, il., bibliogr. 39 poz., sum.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The influence of nitric oxide (NO) on antinociceptive acivity of diazepam (DZ), chlordiazepoxide (CDP) and clonazepam (CZ) was examined using the writhing test in mice. The effect of DZ was also studied in mice using hot plate and tail flick tests. DZ (1.25, 2.5 and 5 mg/kg), CDP (1.25, 2.5, 5, 10 and 20 mg/kg) and CZ (0.075, 0.3125, 0.625, 1.25 and 2.5 mg/kg) produced significant, dose-dependent (DZ CDP) antinociception in mice. The benzodiazepines (BZs)-induced antinociception was antagonized by flumazenil (5 mg/kg) and was not changed by naloxone (2.5, 5 and 10 mg/kg), except that of CZ, which was reversed by 5 mg/kg of naloxone. N**G-nitro-L-arginine methyl ester hydrochloride (L-NAME) as well as 7-nitroinadzole (7-NI) intensified antinociceptive activity of BZs. The antinociceptive effect resulting from co-administration of L-NAME with CZ and 7-NI with CDP was reversed by L-arginine. Methylene blue (MB) increased, whereas L-arginine (but not D-arginine) decreased antinociceptive effects of the studied BZs. These results suggest that the NO-cGMP pathway is involved in the mechanism of BZs-induced antinociception in the writhing test in mice.


    508/2523

    Tytuł oryginału: Effects of tibolone on the development of osteopenia induced by ovariectomy in rats.
    Autorzy: Pytlik Maria
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.35-43, tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Experimental osteopenia caused by ovariectomy in rats may reflect postmenopausal bone changes, which are the effect of osteogen deficiency. The aim of the present study was to investigate the effects of tibolone (0.25 mg/kg/day and 2.5 mg/kg po) administered for 4 weeks on the development of osteopenia caused by bilateral ovariectomy in 3-month-old female Wistar rats. The experiments were carried out on six groups of animals: I(C) - control sham operated rats, II (OVX) - ovariectomized rats, III (OVX+T-0.25) - ovariectomized rats which were administered tibolone at a dose of 0.25 mg/kg, IV (OVX+T-2.5) - ovariectomized rats which were administered tibolone at a dose of 2.5 mg/kg, V (T-0.25) - sham operated rats which were administered tibolone at a dose of 0.25 mg/kg, VI (T-2.5) - sham operated rats which were administered tibolone at a dose of 2.5 mg/kg. The following parameters were examined in all the groups: body weight gain, bone mass, length and diameter, mineral and calcium contents in the tibia and femur, endosteal and periosteal transverse growth, endosteal and periosteal osteoid width, transverse cross-section area of the cortical diaphysis and that of the marrow cavity in the tibia, epiphyseal cartilage width, trabeculae width in the epiphysis and metaphysis of the femur. Mechanical properties of the femur were also studied. Bilateral ovariectomy induced osteopenic skeletal changes in mature female rats. Tibolone (0.25 mg/kg/day and 2.5 mg/kg/day po) administered to ovariectomized rats for 28 days decreased the development of osteopenic skeletal changes induced by bilateral ovariectomy.


    509/2523

    Tytuł oryginału: In vitro cytostatic activity of 8-substituted and tricyclic analogues of acyclovir.
    Autorzy: Hładoń Bogusław, Gośliński Tomasz, Laskowska Halina, Baranowski Daniel, Ostrowski Tomasz, Zeidler Joanna, Ruszkowski Piotr, Golankiewicz Bożenna
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.45-53, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Out of a series of twenty 8-substituted or/and 1,N-2-bridged (tricyclic) derivatives of acyclovir (a selective antiherpetic drug), known to be nontoxic to normal cells, seven compounds were found to exhibit moderate cytostatic activity in KB human tumor tissue culture system with ED50 activity values ranging from 0.052-0.094 x 10**-3 mole/l. The structure-activity relationship analysis indicated that the primary factors determining their cytotoxicity were: 1) bromine atom at the C-8 position of the bicyclic derivatives and 2) unsubstituted appended ring in the tricyclic derivatives. Combination of two structural elements carrying the cytotoxicity gave diverse effects, enhancement or decrease in activity depending on particular cases. Two compounds (of four selected), 8-bromoacyclovir and 1,N-2-ethenoacyclovir, having unsubstituted 9-[(2-hydroxyethoxy)methyl] chain, showed approximately 2-fold increase in their cytotoxicity against HeLa tumor cells in the presence of the induced microsomal generating system suggesting that their cytooxicity depends on the drug metabolic transformation into their active metabolites (intermediates) via MFO-system, and that structural unit of this chain is essential for abovementioned activation. Presently found remarkable cytotoxic selectivity of acyclovir analogues against KB and HeLa tumor cells together with previously reported in the literature specific cytotoxic activity of acyclovir against murine leukemia L1210 cells seem to be encouraging for further investigation of this class of compounds in other tumor systems.


    510/2523

    Tytuł oryginału: Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives.
    Autorzy: Maslat Ahmed O., Abussaud Mahmud, Tashtoush Hasan, AL-Talib Mahmoud
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.55-59, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the present investigation, four 1,3,4-bis-oxadiazole derivatives were synthesized as potential antimicrobial agents. The compounds are: 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]propane (2a), 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]butane (2b), 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]octane (2c) and 5,5'-dibenzylthio-bis-[1,3,4-oxadiazol-2-yl]butane (3). The above newly synthesized compounds were investigated for their antibacterial, antifungal and mutagenic activities. The results of the biological activities revealed that the compounds 2a-c exhibited both antibacterial and antifungal activities against S. aureuss and B. subtilis. Compound 2a also showed activity against P. aeureoginosa. All the above compounds and compound 3 exhibited activity against C. albicans. Genotoxic studies showed that compound 2a had a weak base pair substitution mutagenicity but none of them exhibited a frameshift mutagenic action using Ames test.


    511/2523

    Tytuł oryginału: Prolonged treatment with glucocorticoid dexamethasone suppresses melatonin production by the chick pineal gland and retina.
    Autorzy: Zawilska Jolanta B., Sadowska Magdalena
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.61-66, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • ptaki

    Streszczenie angielskie: The chick pineal gland and retina synthesize melatonin in a circadian rhythm with high levels during the night. The rhythmic changes in the hormone production result predominantly from the fluctuation in the activity of serotonin N-acetyltransferase (AA-NAT), a penultimate and key regulatory enzyme in melatonin biosynthesis. The aim of this study was to analyze the effects of an acute and prolonged in vivo treatment with a glucocorticoid dexamethasone (4 mg/kg, ip) on the nocturnal increase in AA-NAT activity in chick pineal gland and retina. In acute experiments, dexamethasone (single dose)-injected chicks were killed after 2 h, while in prolonged experiments the glucocorticoid was given once daily for 7 days and the animals were killed 26-32 h after the last injection. Acute administration of dexamethasone did not affect AA-NAT activity in the chick pineal gland and retina. In the pineal glands and retinas of chicks that were treated with dexamethasone for one week and then killed at the end of the light phase of the 12:12 h light-dark cycle, AA-NAT activity was significantly higher than the enzyme activity found in tissues isolated from the vehicle-treated (control) animals. In addition to that, the nocturnal increase in pineal and, to a lower extent, retinal AA-NAT activity was significantly lower in dexamethasonetreated birds when compared with the respective control groups. It is suggested that prolonged treatment of animals with dexamethasone reduces the amplitude of the rhythmic melatonin production, a phenomenon which may affect chronobiological processes being under control of this hormone.


    512/2523

    Tytuł oryginału: In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase.
    Autorzy: Altikat Sayit, Ciftci Mehmet, Bykokuroglu Mehmet E.
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.67-71, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The study investigated in vitro effects of halothane, isoflurane, ketamine, sevoflurane, prilocaine, diazepam, and midazolam on enzymatic activity of human red blood cell glucose-6-phosphate dehydrogenase (G6PD; E.C. 1.1.1.49). G6PD was purified from human red blood cells by 2',5'-ADP-sepharose 4B affinity gel. Enzymatic activity was spectrophotometrically measured at 340 nm according to the method of Beutler. I50 values were determined from drug activity 9p.c.) - drugconcentration curves. I50 values were as follows: 0.72 mM for isoflurane, 1.82 mM for sevoflurane, 0.38 mM for diazepam, and 0.0019 mM for midazolam. But halothane, ketamine and prilocaine had no inhibitory effect on the G6PD activity in in vitro.


    513/2523

    Tytuł oryginału: Inhibition of arachidonic acid cascade attenuates the induction of c-Fos proteins by DOI, 5-HT2A/2C receptor agonist, in the rat cortex.
    Autorzy: Maćkowiak Marzena, Czyrak Anna, Wędzony Krzysztof
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.73-76, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Previous immunohistochemical studies have shown that c-Fos proteins induced by DOI, a 5-HT2A/2C agonist, are present in the population of cortical neurons, which are devoid of 5-HT2A receptors. A mechanism of the induction of c-Fos proteins expression by DOI is still unclear. However, the involvement of the 5-HT2A and AMPA, but not 5-HT2C receptors in this process has been reported. In the present study, we investigated whether arachidonic acid, a retrograde messenger, is involved in the above mechanism of c-Fos induction. Phospholipase A2 pathway, which leads to the subsequent generation of arachidonic acid and its metabolites, is known to be coupled to 5-HT2A receptor activation. The inhibition of arachidonic acid cascade both at the level of phospholipase A2 (by dexamethasone, 1.5 mg/kg0 or at the level of cyclooxygenases that catalyze arachidonic acid biotransformation (by indomethacin, 3 mg/kg), decreased the number of c-Fos immunopositive cells after induction by DOI (8 mg/kg). Our results suggest that arachidonic acid cascade may be involved in the induction of c-Fos proteins by DOI in the rat parietal cortex.


    514/2523

    Tytuł oryginału: Sixth Conference on Progress in Etiopathogenesis of Seizures.
    Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.77-84 - 6 Konferencja nt. etipatogenezy drgawek Lublin 16.11. 2001
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • streszczenie

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy


    515/2523

    Tytuł oryginału: Emotional changes related to age in rats - a behavioral analysis.
    Autorzy: Boguszewski Paweł, Zagrodzka Jolanta
    Źródło: Behav. Brain Res. 2002: 133 (2) s.323-332, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 312,662

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The present study investigated age-related differences in the emotional behavior of rats using factor analysis to identify motivational factors influencing spontaneous behavior in open field with illuminated center (OF), plus maze (EPM) and social interactions test. Animals of the same strain, bred under the same conditions, formed two experimental groups: yound adults (YA, N - 20) tested at the age of 4 months and old rats (OA N = 16) tested at the age of 24 months. The comuter video based tracking system Etho Vision was used for automated acquisition and analysis of data. The reslults of each test were analyzed separately for YA and OA by factor analysis. Two main independent factors emerged from the analysis of OF measures - factor 1, which appeared to reflect motor activity, and factor 2, reflecting anxiety. The measures best reflecting motor activity (distance moved in the peripheral zone) and anxiety (time spent in central zone) decreased significantly with age. Factor analysis for EPM measures revealed, in both groups, three independent factors. In YA, factor 1 reflected motor activity, factor 2 - anxiety, in OA measures of anxiety loaded on factor 1, measures of activity on factor 2. Factor 3 in both groups appeared to represent a decision making process. The number of entries to the closed arms declined significantly in OA, showing an age related decrease of motor activity. Also, the ratio of open arms entries in relation to the total number of entries decreased in OA, indicating a higher anxiety level...


    516/2523

    Tytuł oryginału: Obesity-related hypertension: relevance of vascular responses to mental stress.
    Autorzy: Narkiewicz Krzysztof
    Źródło: J. Hypertens. 2002: 20 (7) s.1277-1278, bibliogr. 21 poz.
    Sygnatura GBL: 313,132

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    517/2523

    Tytuł oryginału: Virulence properties of Escherichia coli faecal strains isolated in Poland from healthy children and strains belonging to serogroups O18, O26, O44, O86, O126 and O127 isolated from children with diarrhoea.
    Autorzy: Paciorek Jarosław
    Źródło: J. Med. Microbiol. 2002: 51 (7) s.548-556, il., tab., bibliogr. 58 poz.
    Sygnatura GBL: 305,350

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Four hundred and twetny-seven Escherichia coli isolates from 427 cases of infantile diarrhoea in Poland, belonging to serogroups O18, O26, O44, O86, O126 and O127 and 150 E. coli isolates from 52 healthy children were examined for selected virulence properties. The presence of the plasmid pAA, a plasmid encoding enteroheamolysin, the genes encoding intimin (eae), bundle-forming pili (bfp), Shiga toxins I and II (stxI, stxII) and cytotoxic necrotising factor types 1 and 2 (cnf1, cnf2) was investigated by PCR. Adhesion to HEp-2 cell monolayers was also tested and selected strains were investigated for the presence of P-fimbriae and haemolytic activity. Typical enteropathogenic E. coli isolates (typical EPEC, strains possessing eae and bfp, but not stx) were not found. The particular classes of E. coli among 427 isolates from ill children were: atypical EPEC (eae**+ bfp, stx**-), 21.3 p.c.; Shiga toxin-producing E. coli (STEC), 0.7 p.c.; diffsely adherent E. coli (DAEC), 4 p.c.; enteroaggreagative E. coli (EAEC), 16.9 p.c.; necrotoxic E. coli type 1 (NTEC1), 0.2 p.c.; and cell-detaching E. coli (CDEC), 29 p.c. With the exception of STEC, all the above classes of E. coli were found among the isolated from healthy children which comprised: atypical EPEC 8.0 p.c., DAEC 6.7 p.c.; EAEC 17.3 p.c., NTEC1 14.0 p.c. and CDEC 40.0 p.c. Cell detachment (CD) was significantly associated with 3-h haemolytic activity. There was also strong correlation between haemolytic activity (Hly) and the presence of p-fimbriae. No correlation was found between the presence of te cnf1 gene and CD, Hly or P-fimbriae.


    518/2523

    Tytuł oryginału: Cytokine serum levels in soft tissue sarcoma patients: correlations with clinico-pathological features and prognosis.
    Autorzy: Rutkowski Piotr, Kamińska Janina, Kowalska Maria, Ruka Włodzimierz, Steffen Jan
    Źródło: Int. J. Cancer 2002: 100 (4) s.463-471, il., tab., bibliogr. 85 poz.
    Sygnatura GBL: 305,029

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: We investigated the correlations between serum levels of selected proinflammatory, hematopoietic and angiogenic cytokines and soluble cytokine receptors with the clnicopathological features and prognosis in soft tissue sarcom patients. Serum levels of 9 cytokines (TNFŕ, IL-Ira, IL-6, IL-8, IL-10, M-CSF, G-CSF, VEGF, bFGF) and 4 free cytokine receptors (sIL-2Rŕ, sIL-6R, TNFRI TNFRII) were measured by means of an enzyme-linked immunoadsorbent assay kit in 156 soft tissue sarcoma patients before the treatment and in 50 healthy controls. Serum levels of 10 cytokines and cytokine receptors were also assayed during patients' follow-up after the treatment. Significantly elevated pretreatment serum levels of 11/13 cytokines and cytokine receptors were found in sarcoma patients, as compared to healthy controls. In 40.4 p.c. of patients 6 or more cytokines and cytokine receptors (most frequently: TNF RI, IL-6, IL-8) were elevated in parallel. Serum levels of IL-6, sIL-2R, VEGF, M-CSF and TNF RI correlated significantly with tumor size and serum levels of IL-8 and IL-6 were significantly higher in patients with Grade 2/3 vs. Grade I tumors. We did not observe any significant differences in cytokine serum levels between patients with primary and recurrent tumors and patients with and without distant metastases. Using univariate analysis, overall survival (OS) in all patients was affected by tumor size ( 5 cm vs. 5-10 cm vs. 10 cm), tumor grade (GI vs. G2/3), presence of metastases, pretreatment serum levels of 8 cytokines...


    519/2523

    Tytuł oryginału: Professor Bogusław Żernicki (1931 - 2002).
    Autorzy: Wróbel Andrzej, Zagrodzka Jolanta, Doty Robert, Zieliński Kazimierz, Kozak Włodzimirz M., Mishkin Mortimer, Buser Pierre, Buser Arlette, Harutiunian-Kozak Bella, Turlejski Krzysztof, Morrison Adrian R., Brennan James F., Sobótka Stanisław, Yinon Uri, Gottesmann Claude, Villablanca Jaime R., Wilson W. Jeffrey
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.i-ix, il.
    Sygnatura GBL: 302,090

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Żernicki
  • Bogusław 1931-2002


    520/2523

    Tytuł oryginału: Involvement of MMPs in delayed neuronal death after global ischemia.
    Autorzy: Zalewska Teresa, Ziemka-Nałęcz Małgorzata, Sarnowska Anna, Domańska-Janik Krystyna
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.53-61, il., bibliogr. s. 59-61
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Spatial and temporal relations between metalloproteinase (MMP-2 and MMP-9) activation and laminin degradation in garbil hippocampus after transient cerebral ischemia has been studied. Activity of MMPs was determined by gelatin zymography in homogenates from dorsal (DP, an equivalent of CA1 sector) and abdominal (AbP, containing CA2-4 and gyrus dentatus) parts of hippocampus. A significant activation of both investigated metalloproteinases was found at 72 h of recovery. Whereas MMP-2 up-regulation did not show any spatial preferences, the increase of MMP-9 activity was observed exclusively in DP. Activation of MMP-9 at this time point correlated spatially with degradation of laminin - protein of extracellular matrix. These results show that MMP pathway may function as a component of delayed neuronal death cascade in the apoptogenic CA1 sector after transient global ischemia.


    521/2523

    Tytuł oryginału: Fear behavior and regional brain monoamines distribution after R(+)-8-OHDPAT and R(+)-UH-301 injections into the dorsal raphe nucleus in rats.
    Autorzy: Koprowska Milena, Krotewicz Maria, Romaniuk Andrzej, Strzelczuk Magdalena, Wieczorek Marek
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.63-74, il., tab., bibliogr. s. 73-74
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The effects of 8-OHDPAT and UH-301 injection into the dorsal raphe nucleus (DRN) on fear behavior of the light-dark transitions test and regional brain monoamines (NA, DA, 5-HT) and their metabolites (MHPG, DOPAC, 5-HIAA) in the hypothalamus (HPT), midbrain central gray matter (MID), amygdala (AMY), hippocampus (HIP) and pons (PO) were examined. An injection of 8-OHDPAT (300 ng) as well UH-301 (300 ng) into the DRN evoked an increase in the number of head dipping from dark to the iluminated compartment of chamber, an increase of time of motionless in the dark compartment and decrease of time of locomotion activity in the illuminated compartment. HPLC analysis showed reduction of 5-HIAA/5-HT ratio in the HPT, HIP and PO, increase of MHPG/NA ratio in the HIP and PO, and increase of DA content in the HPT, AMY and HIP after 8-OHDPAT injection. But injection of UH-301 reduced 5-HT in the MID and increased in the AMY, reduced 5-HIAA content in the HIP and increased in the MID and decreased MHPG/NA ratio in the PO. These results indicate that both 5-HT1A receptor agonists, acting on the 5HT1A autoreceptors caused the anxiolytic effects, reduced fear behavior on the rat connected with infringement of dynamic balance between the serotonergic and catecholaminergics systems.


    522/2523

    Tytuł oryginału: Behavioural responsiveness to amphetamine or scopolamine following repeated exposure to chlorphenvinphos in rats.
    Autorzy: Gralewicz Sławomir, Lutz Piotr, Tomas Tadeusz
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.75-83, il., tab., bibliogr. [24] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. It is known that rats with cholinergic hyperreactivity are behaviourally hyposensitive to cholinergic antagonists and dopaminergic agonists. The purpose of the present study was to find out whether a similar trait would develop in rats exposed to chlorphenivinphows (CVP), an OP pesticide, in the past. The rats wre given ten daily i.p. injections of CVP at doses of 0.5 mg/kg (group P-0.5) or 1.0 mg/kg (group P-1.0). The locomotion stimulating effect of i.p. injection of 1.0 mg/kg amphetamine (AMPH), or 0.6 mg/kg scopolamine (SCOP), was assessed on postexposure day 21 (group P-0.5) or 42 (group P-1.0), i.e. after a time suffcient for AChE recovery. The assessment revealed that in gorup P-1.0 the behavioural response to AMPH and SCOP was significantly depressed. In rats of the P-0.5 group, however, the behavioural response to each of the frugs was increased. The results suggest that, depending on the exposure level, contrasting alterations in some neurotransmitter systems may be induced by repeated exposure to CVP.


    523/2523

    Tytuł oryginału: Correlation between long latency evoked potentials from amygdala and evoked cardiac response to fear conditioned stimulus in rats.
    Autorzy: Kuniecki Michał, Coenen Anton M. L., Kaiser Jan
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.85-92, il., bibliogr. s. 90-92
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: We investigated relation between activity of central nucleus of amygdala (CE) and phasic heart rate deceleration during differential fear conditioning. We found that P2 component of long-lasting event potential (EP) to CD+ but not to CS- correlated strongly with HR deceleration in the 1 st second after stimulus onset. The obtained results are discussed in the light of LeDoux's and Kapp's findings showing crucial role of amygdala in processing of emotionally relevant stimulation and it's involvement in initiating autonomic responses.


    524/2523

    Tytuł oryginału: Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat.
    Autorzy: Gralewicz Sławomir
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.93-98, il., bibliogr. s. 97-98
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Earlier experiments have revealed that rats treated with a single dose of chlorphenvinphos (CVP), an irreversible acetylchlinesterase inhibitor, are hyposensitive to amphetamine (AMPH) given three weeks after CVP. Exposure to CVP results in an excess of acetylcholine with subsequent overactivation of the nicotinic as well as muscarinic cholinergic receptors. The purpose of the present experiment was to find out whether a selective activation of muscarinic receptors could induce behavioral hyposensitivity to AMPH. To attain this purpose, male rats were pretreated once with 0.00, 0.135, 0.27 or 0.55 mg/kg of oxotremorine, a muscarinic agonist, and challenged 15 days later with 1.0 mg/kg dose of AMPH. The pre- and postinjection open-field behavior of the rats was tested with the use of a computerized set of activity meters. The testing revealed that in oxotremorine pretreated animals the behvioral response, to AMPH, i.e. increase in the ambulatory activity, was not diminished but, to the contrary, it was augmented. This effect was dose-dependent, being most pronounced in rats given the 0.55 mg/kg of oxotremorine. The possible cause of the difference between the effect of CVP and oxotremorine is discussed.


    525/2523

    Tytuł oryginału: Affective percept and voluntary action: a hypothesis.
    Autorzy: Żernicki Bogusław
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.99-110, il., tab., bibliogr. s. 108-110
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: I present a hypothesis concerning the neuronal, mental and behavioral effects of all kinds of affective (emotional) stimuli, i.e., of unpleasant and pleasant stimuli. I use the term stimulus in its broad sense. Affective stimuli evoke two associated percepts: "cognitive" and "affective". A food in the mouth, for example, evokes the gustatory percept and the percept of pleasure. However, affective percepts are unstable parts of cognitive-affective compounds. Five types of affective percepts are pain, fear, pleasure, "desire" and appetite in the broad sense of these words. Desire is evoked by inadequate pleasant stimuli. Affective percepts are "lower" or "higher". The latter are not directly associated with bodily needs. Esthetic and social percepts are higher, for example. Although pain and pleasure are essentially innate, they can be modified by sensory experience. Alimentary and esthetic preferences and social values are modifiable, for example. The neurons of pain and fear and of the unpleasant components of desire and appetite motivate four types of voluntary actions. These are, respectively, escape, avoidance, "optimization" and approach actions. All these actions eliminate the motivating displeasure. In addition, avoidance actions protect from the signaled pain, optimization actions increase the existing pleasure and approach actions provide the signaled pleasure. Thus, voluntary actions associated with different percepts occur according to one universal principle. Voluntary actions are "internal" and behavioral. During internal actions a goal and then an action plan are decided. These actions often provide the images of the goal stimuli and of particular movements.


    526/2523

    Tytuł oryginału: Drug addiction as drive satisfaction ("antidrive") dysfunction.
    Autorzy: Kostowski Wojciech
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.111-117, il., bibliogr. [31] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Drug addiction is a complex brain disorder, characterized by the loss of control over drug seeking and drug taking behavior, and by the risk of relapse, even after a prolonged period of abstinence. This disorder may have its source in a disturbed balance of drive-related behaviors, which control appetitive reactions aimed at seeking contact with an addictive substance. The act of consumption becomes more and more attractive, and the behavior takes on compulsive character. We suppose that drug addiction may involve a change in the mechanism of satisfaction of drives and states of satiation as well. To understand how the motivational processes are changed with the development of dependence, one must consider the mechanism of drive satisfaction and satiation states that occur in relation to the consumatory reflex. When a given drive is satisfied a state of fulfilament occurs. This state may be a result of a so-called "antidrive" mechanism (Konorski 1967). While a drive activity is characterized by general activation and tension, the drive satisfaction state ("antidrive") is characterized by relaxation and releif. When a particular drive is satisfied, the operation of other drives become possible. Therefore, we postulate that dysfunction of drive satisfaction leads to the sustained activation related to the current drug-related drive, which blocks the operation of other drives. In effect, uncontrolled compulsive appetitive behavior is released, and the operation of other drives is restrained, thus forcing the organism to focus on drug-related drive. The reason for an "antidrive" dysfunction may be related to adaptive changes which develop during a contact with an addictive substance.


    527/2523

    Tytuł oryginału: Environmental thermal stress.
    Autorzy: Keim Samuel M., Guisto John A., Sullivan, jr John B.
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.1-15, il., tab., bibligor. 59 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • ochrona środowiska

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Thermal stress from cold and heat can affect health and productivity in a wide range of environmental and workload conditions. Health risks typically occur in the outer zones of heat and cold stress, but are also related to workload. Environmental factors related to thermal stress are reviewed. Individuals undergo thermoregulatory physiologic changes to adapt and these changes are reviewed. Head and cold related illnesses are reviewed as well as their appropriate therapy. Published standards, thresholds and recommendations regarding work practices, personal protection and types of thermal loads are reviewed.


    528/2523

    Tytuł oryginału: Becterial and fungal aerosols in indoor environment in Central and Eastern European countries.
    Autorzy: Górny Rafał L., Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.17-23, tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Studies of indoor bioaerosols conducted in Central and Eastern European countries, as a result of the scarcity of funding, mostly do not attain the level presented by similar studies in Northern America and Western Europe. For socio-economic reasons, most of the intense studies on indoor bioaerosols in Central and Eastern European countries were carried out in industrial facilities and have contributed significantly to occupational health science. In contrast, until recently, insufficient of studies have been conducted on bioaerosols of residental and communal premises (dwellings, offices, schools, etc.) and no network for monitoring the microbiological quality of air in such premises exists. In Poland, in the mid-1990s complex bioaerosol investigations were carried out by the Bioaerosol Group at the Institute of Occupational Medicine and Environmental Health in Sosnowiec. The concentrations of airborne bacteria and fungi in dwellings without mold problems were between 88 - 4297 cfu/m**3 and 0 - 1997 cfu/m**3, while in moldy homes they were 178 - 4751 cfu/m**3 and 49 - 16968 cfu/m**3, respectively. As many as 167 microbial species were isolated from the air of examined dwellings. Most frequently occurred Gram-positive cocci (Micrococcus/Kocuria spp., Staphylococcus spp.), endospore-forming bacilli (Bacillus spp.), Gram-negative bacteria (Pseudomonadaceae, Aeromonas spp.), filamentous fungi (Penicillium spp., Aspregillus spp.), and yeasts. Notable studies of indoor bioaerosols have also been performed in the other Central and Eastern European countries: Lithuania, Latvia, Estonia,...


    529/2523

    Tytuł oryginału: Coexistence DNA of Borrelia burgdorferi sensu lato and Babesia microti in Ixodes ricinus ticks from north-western Poland.
    Autorzy: Skotarczak Bogumiła, Wodecka Beata, Cichocka Agnieszka
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.25-28, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The tick Ixodes ricinus may carry microorganisms which cause serious human and animal diseases, i.a., the Lyme diseases (borereliosis), caused by the spirochaete Borrelia burgdorferi sensu lato and babesiosis, induced by the protozoan Babesa microti. Both microbe species may co-occur in the same and other species of the genus tick and produce a mixed infection in humans and animals. The major objective of the study was to identify DNA of B. burgdorfere and B. microti in the I. ricinus ticks collected in spring and autumn 1999 from 6 sites in north-western Poland. The microbial DNA was identified with polymerase chain reaction (PCR). The marker used to detect the B. burgdorferi s.l. DNA was a fragment of the fla gene encoding the protein flagellin, while the B. microti DNA was detected with a fragment of the gene encoding 16S rRNA. A total of 550, 1,160, and 385 tick adults, nymphs, and larvae, respectively, were examined. Among the 155 (7.4 p.c.) B. burgdorferi-infected ticks and the 130 (6.2 p.c.) infected with B. micron, mixed infection was detected in 0.6 p.c. of individuals. The prevalence of coinfection differed between the tick developmental stages. Coinfection was most prevalent (3.1 p.c.) in females, males and nymphs being less affected (0.4 and 0.2 p.c., respectively). No coinfection was revealed in the tick larvae. The study described was the first of its kind to be conducted in the former District of Szczecin. For the phenomenon of microbial co-occurence and related mixed infections to be properly evaluated, the researach will be continued.


    530/2523

    Tytuł oryginału: The use of the radioisotope method in studies of pesticide penetration into the eyeball.
    Autorzy: Gerkowicz Marek, Wróblewska Ewa, Turski Waldemar
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.29-31, bibliogr. 10 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • okulistyka

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: The studies concerning the effects of pesticides on the human body focused mainly on their local action or chronic poisoning of the organism. In this study we examine the pesticide penetration into the eyeball resulting from direct contact with the eye. We used an isotope-labelled carbamate pesticide - carbaryl. The determinations of the amount and concentration of this substance in the cornea, aqueous humour, vitreous humour and retina were performed using the method measuring á radiation emitted by radioactive carbon. The results revealed measurable concentrations of labelled carbamate in the cornea and aqueous humour 10 and 30 min after application. The levels of this pesticide in the vitreous homour and retina were very low and difficult to analyse statistically. The described method appears to be useful in determining the range and rate of eye penetration by environmental toxings having direct contact with the eyeball.


    531/2523

    Tytuł oryginału: House dust mites and their allergens in Danish mattresses - results from a population-based study.
    Autorzy: Sidenius Kirsten E., Hallas Thorkil E., Poulsen Lars K., Mosbech Holger
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.33-39, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The purpose of this study was to identify the level of house dust mites (HDMs) and their allergens in matresses, not selected on their owners atopic status, and to find associated factors. Dust was collected from 68 matresses. The recruitment was population-based and conducted during the screening phase of a HDM intervention study. The visited persons declared to have had a "cold" bedroom the previous winter. HDMs were counted and dust was analysed by ELISA for Der 1 (= Der f 1 + Der p 1 + Der m 1). Multiple regression analysis was carried out to find housing conditions associated with high MDM levels. Type of housing, mattress age and self-assessed winter bedroom-temperature explained 14 p.c. of Der 1. Median concentrations were 3.77 ćg Der 1/g and 1 HDM/0.1 g dust. Both immunochemically and microscopically Dermatophagoides farinae was dominant; D. pteronyssinus less frequent but important; and D. microscopisally Dermatophagoides farinae was dominant; D. pteronyssinus less frequent but important; and D. microceras insignificant. In 62 p.c. of these suburban homes the mattress dust exceeded 2 ćg Der 1/g, and measurement of both Der f 1 and Der p 1 was necessary and sufficient to evaluate HDM allergen exposure. The association with a high HDM level was highest and most consistent for one-family houses.


    532/2523

    Tytuł oryginału: Air contaminants in different European farming environments.
    Autorzy: Radon Katja, Danuser Brigitta, Inversen Martin, Monso Eduard, Weber Christoph, Hartung J”rg, Donham Kelley J., Palmgren Urban, Nowak Dennis
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.41-48, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Farmers are known to be at high risk from the development of occupational airway disease. The first stage of the European farmers' study has shown that pig farmers in Denmark and Germany, poultry farmers in Switzerlad and greenhouse workers in Spain were at highest risk for work-related respiratory symptoms. Therefore, the aim of this study was to determine exposure levels at relevant farm workplaces. Dust and endotoxin levels as well as microbiological concentrations were determined in 213 crop and animal farming environments by personal sampling. The highest total dust concentrations were found in poultry houses in Switzerland with median concentrations of 7.01 mg/m**3. The median airborne endotoxin concentrations in total dust ranged between 0.36 ng/m**3 in Spanish greenhouses and 257.58 ng/m**3 in poultry houses in Switzerland. Likewise, the highest median concentrations of total (2.0 x 10**7 cells/m3) and active fungi (4.4 x 10**5 cfu/m**3) have been found in Swiss poultry houses. The predominant fungus taxa discovered in poultry houses were Eurotium spp. and thermophilic fungi. Cladosporium and Botrytis were mainly detecated in greenhouses. The exposure level found in this study might put the farmers at risk from respiratory diseases.


    533/2523

    Tytuł oryginału: Second inter-laboratory study comparing endotoxin assay results from cotton dust.
    Autorzy: Chun David T. W., Chew Victor, Bartlett Karen, Gordon Terry, Jacobs Robert R., Larsson Britt-Marie, Lewis Daniel M., Liesivuori Jyrki, Michel Olivier, Rylander Rangar, Thorne Peter S., White Eugene M., Gunn Varina C., Wrtz Helle
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.49-53, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Previously, a large two-part inter-laboratory round robin endotoxin assay study was completed. This first study showed that when cotton dust samples, which are practically identical, are assayed for endotoxin that the intra-laboratory results had a very small variation while intra-laboratory results of the sample had a very high variation. In the first part of the study, each laboratory results of the sample had a very high variation. In the first part of the study, each laboratory followed its own in-house assay protocol; but in the second part of the study, when the extraction protocol was standardized, the inter-laboratory results showed a lower variation, which suggested that with further standardization, further reduction of differences between laboratories might be achieved in order that results between laboratories would become more comparable. The results stimulated interest in extending the study to include cotton dust with two levels of endotoxin, standardization of the extraction proteocol, and using the same assay kit from the same production lot. The results of this second round robin endotoxin assay study indicate that differences between laboratories are still high, but most of the laboratories could discern the cotton dusts with the different levels of endotoxin.


    534/2523

    Tytuł oryginału: Detection of Borrelia burgdorferi sensu lato in mosquitoes (Culicidae) in recreational areas of the city of Szczecin.
    Autorzy: Kosik-Bogacka Danuta, Bukowska Katarzyna, Kuźna-Grygiel Wanda
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.55-57, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The mosquitoes were caught within the period of their highest activity, i.e. June-August 2001, in recreational areas of the city of Szczecin. Spirochetes, Borrelia burgdorferi sensu lato were detected in mosquitoes with the aid of the method of indirect immunofluorescence (IFA) using rabbit anti-Borrelia burgdorfere antibodies and goat anti-rabbit IgG marked with fluorescein isothiocyanate (FITC). A total of 639 mosquito females representing genera A‰des (99.1 p.c.) and Culex (0.9 p.c.) were collected. The mean value of the infection rate of mosquitoes from the area studied was 1.25 p.c. The highest infection rate was recorded in June (3.2 p.c.), while the lowest - in July (0.6 p.c.). All mosquitoes infected with Borrelia burgdorferi spirochetes belonged to the gnus A‰des. The results of the present study confirm a potential role of those arthropods in epidemiology of Lyme borreliosis.


    535/2523

    Tytuł oryginału: Indoor fungi and their ciliostatic metabolites.
    Autorzy: Pieckova Elena, Kunova Zuzana
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.59-63, tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • zarodki

    Streszczenie angielskie: According to epidemiological studies, it is possible that some secondary metabolites of indoor airborne fungi could be responsible for health troubles which occupants sufer from. In our previous experiments, a model with tracheal rings of 1-day-old chicks in vitro was shown to be a very suitable method to study the ciliostatic chloroform-extractable endo- end/or exometabolites of filamentous fungi. In this study we isolated the filamentous fungi from walls of "moudy" dwellings and schools (cultivation on dichloran 18 p.c. glycaerol agar at 25 and 37řC for 10 d) in Slovakia. We studied the ciliostatic effect of the chloroform-extractable endo- and exometabolites of 96 representative isolates (Stationary cultivation on the liquid medium with 2 p.c. of yeast extract and 10 p.c. of sucrose at 25řC for 10 days) on the cilia movement in tracheal organ cultures of 1-day-old chickens in vitro after 24, 48 and 72 hrs (incubation in the minimal essential medium according to Eagle with Earl's salts and 20 ćg of extract of metabolites dissolved in dimethylsulfoxide per 1 mL). Strains of Penicillium Link: Fr. sp., Aspregillus versicolor (Vuill.). Tiraboschi, A. flavus Link, Cladosporium sphaerospermum Penzig adn C. cladosporioides (Fres.) de Vries were isolated most frequently. Two A. flavus isolates were able to produce aflatoxins B1, B2, G1, G2 in vitro after cultivation on the liquid medium with 20 p.c. sucrose and 2 p.c. yeast extract. This is the first isolation of aflatoxigenic A. flavus strains from dwellings in Slovakia. All frequently isolated strainsproduced secondary metabolites...


    536/2523

    Tytuł oryginału: Betula and Populus pollen counts and meteorological conditions in Szczecin, Poland.
    Autorzy: Puc Małgorzata, Wolski Tomasz
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.65-69, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,158

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of the study was to analyse a relationship between the meteorological conditions and the pollen count of selected allergenic taxa (Betula spp., Populus spp.) in the air of Szczecin city (north western Poland) in 2001. Apart from the individual rhythm of plant pollination, weather conditions are considered the most important factors determining the dispersion and content of pollen in the air. The meteorological parameters analysed were the minimum, maximum and average values of air temperature, relative humidity, solar radiation and wind speed. The beginning and end of a season were established by the 98 p.c. method. The concentration of birch pollen in the air in 2001 was very high, the pollen season started in the third decade of April and lasted till the 10 May. The highest airborne concentration of 3.712 grains in 1 m**3 per 24 h was noted at the beginning of May on a sunny day with strong wind, and air temperature above 20řC. The concentration of poplar pollen in 2001 was low. The pollen season started from the beginning of April and lasted till the beginning of May. The maximum concentration of airborne poplar pollen of 222 grains in 1 m**3 per 24 h was observed in the third decade of April and was preceded by several days with low temperature (1 - 2řC), rain, snowfalls and strong wind. A positive and statistically significant correlation was found between the air temperature and the birch pollen concentration, while a similar but negative correlation was found for poplar pollen.


    537/2523

    Tytuł oryginału: Qualitative and quantitative analysis of agricultural dust in working environment.
    Autorzy: Mołocznik Anna
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.71-78, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • ochrona środowiska
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The presented quantitative and qualitative analysis of dust in agricultural working environment is a continuation of the process of recognizing the exposure to dust among private farmers. The study covers the following: determination of respirable fraction of dust in the respiratory zone (on the background of total dust) whileperforming individual farming activities which constitute an annual work cycle, organic and mineral components of settled dust for basic groups of farming activities, and the main mineral pathogenic component - free silica in airborne and setled dust. The study was conducted on 5 farms specialising in: cultivation of cereals, root plants, vegetables, dairy cattle and swine breeding and mixed production. The analysis of settled dust covered 17 types of dust accompanying field work and farm/indoor activities. Studies of airborne dust were conducted on farmers while performing 40 main work activities which contributed to the annual work cycle. Results of the study confirmed the following: agricultural work activities are accompanied by a high level of dustiness and showed the presence of a respirable fraction in airborne dust of up to 25 p.c., a higher level of pathogenic free silica SiO2 in setled dust samples in the working environment of a farmer, compared to dust in respiratory zone, a comparable level of SiO2 in total and respirable airborne dust, and a high level of organic component in settled dust at work activities with plant material. These results indicated that the evaluation of farmers' exposure to dust should be based on the examination of samples taken in the respiratory zone while performing individual work activities.


    538/2523

    Tytuł oryginału: Selected socio-economic features and the prevalence of peptic ulcer among Polish rural population.
    Autorzy: Schabowski Janusz
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.79-84, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The aim of the study was to determine the realtionship between the prevalence of peptic ulcer and the occurrence of selected socio-economic features among Polish rural population. The study was conducted based on the all-Polish representative study of the state of health of rural population, and covered a group of 6,512 rural inhabitants age 20 - 64 - 3,107 males and 3,405 females selected by twostage stratified sampling. Peptic ulcer was diagnosed in 348 people in the study (5.3 p.c.): 250 males (8.0 p.c.) and 98 females (2.9 p.c.). Duodenal ulcer occurred in 3.2 p.c. of people examined, followed by gastric ulcer - .2 p.c., duodenal and gastric ulcer - 0.2 p.c., and 0,9 p.c. of patients underwent surgical procedures due to peptic ulcer. Peptic ulcer occurred more frequently among people with a lower education level (lack of education - 7.8 p.c., elementary school education - 5.8 p.c.), compared to those with higher education categories (elementary vocational - 4.9 p.c., secondary school and college - 3.7 p.c.). The disease was more often diagnosed among respondents who described their material standard as poor (7.7 p.c.), compared to those who described this standard as good (4.0 p.c.). Among people who considered their material standard as poor, gastric ulcer was noted more frequently than duodenal ulcer. A correlation was observed between the prevalence of peptic ulcer and such socio-economic features of Polish rural population as the level of education and material standard.


    539/2523

    Tytuł oryginału: Exposure to airborne microorganisms in furniture factories.
    Autorzy: Krysińska-Traczyk Ewa, Skórska Czesława, Cholewa Grażyna, Sitkowska Jolanta, Milanowski Janusz, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.85-90, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • ochrona środowiska
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Microbiological air sampling was performed in 2 furniture factories located in eastern Poland. In one factory furniture were made from fibreboards and chipboards while in the other from beech wood. It was found that the concentration of total microorganisms (bacteria + fungi) in the air of the facility using beech wood for furniture production (mean 10.7 x 10**3 cfu/m3, range 3.3 - 27.5 x 10**3 cfu/m**3) was significantly higher (p 0.01) compared to microbial concentration in the facility using fibre- and chipboards (mean 3.6 x 10**3 cfu/m3, range 1.9 - 6.2 x 10**3 cfu/m**3). On average, the commonest microorganisms in the air of the furniture factories were corynebacteria (Corynebacterium spp., Arthrobacter spp., Brevibacterium spp.) which formed 18.1 - 50.0 p.c. of the total airborne microflora, and fungi (mostly Aspergillus spp., Penicillium spp. and yeasts) which formed 6.2 - 54.4 p.c. of the total count. The values of the respirable fraction of airborne microflora in the furniture factories varied within fairly wide limits and were between 15.0 - 62.4 p.c. Altogether, 28 species or genera of bacteria and 12 species or genera of fungi were identified in the air of examined factories, of which respectively 8 and 7 species or genera were reported as having allegenic and/or immunotoxic properties. In conclusion, the workers of furniture factories are exposed to relatively low concentrations of airborne microorganisms which do not exceed the suggested occupational exposure limits. Nevertheless, the presence of allergenic and/or immunotoxic microbial species in the air of factories poses a potential risk of respiratory disease, in particular in sensitive workers.


    540/2523

    Tytuł oryginału: Response of furniture factory workers to work-related airborne allergens.
    Autorzy: Skórska Czesława, Krysińska-Traczyk Ewa, Milanowski Janusz, Cholewa Grażyna, Sitkowska Jolanta, Góra Anna, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.91-97, tab., bibliogr. 46 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this work was to determine the reactivity of furniture factory workers to microbial allegens associated with wood dust. Allergological examinations by skin and precipitin tests were performed in 48 workers employed in a factory producing furniture from fibreboards and chipboards, and in 32 healthy urban dwellers not exposed to organic dusts (referents). The skin test was performed by the intradermal method with the saline extracts of the cultures of 3 microbial species (Rahnella sp., Arthrobacter globiformis, Aspergillus fumigatus) associated with wood dust. Skin reactions were recorded after 20 minutes, 8 hours and 24 hours and graded 1 - 4, depending on the diameter of the reaction. The agar-gel test for the presence of precipitins in serum was performed with the extracts of 15 microbial isolates. The furniture factory workers showed a high skin response to the extracts of environmental microbes. The frequency of early grade 2 reactions (diameter 10 mm) to the extract of Rahnella sp. was 64.6 p.c. among furniture workers, being significantly higher (p 0.001) compared to reference group (18.7 p.c.). High frequencies of grade 2 reactions in furniture workers were also found with the extracts of A. globiformis and A. fumigatus (52.1 p.c. and 62.5 p.c., respectively). The frequencies of grade 2 delayed (after 8 h) and late (after 24 h) reactions to Rahnell sp. in furniture workers were non-specifically high (97.9 p.c./93.7 p.c.) while the response rates to A. globiformis and A. fumigatus were much lower (10.4 p.c./25.0 p.c., and 4.2 p.c./37.5 p.c., respectively). In agar-gel test for detection of precipitins, in most cases very low percentages...


    541/2523

    Tytuł oryginału: Work-related symptoms among furniture factory workers in Lublin region (eastern Poland).
    Autorzy: Milanowski Janusz, Góra Anna, Skórska Czesława, Krysińska-Traczyk Ewa, Mackiewicz Barbara, Sitkowska Jolanta, Cholewa Grażyna, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.99-103, tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: 48 woodworkers employed in the furniture factory were examined. The control group consisted of 41 office workers with no exposure to organic dust. The examination included: interview on work-related symptoms, physical examination, and lung function test performed before and after the working-day. 38 out of 48 (79.2 p.c.) woodworkers reported work-related symptoms. The most common complaint was dry cough reported by 25 workers (52.1 p.c.), followed by general malaise - reported by 17 (35.45 p.c.), cojunctivitis - by 16 (33.3 p.c.), rhinitis - by 16 (33.3 p.c.), and skin symptoms by 16 (33.3 p.c.). Other symptoms such as headache, shortness of breath and chest pain occurred less frequently. Subjects working in initial processing and board processing departments had a higher prevalence of cough compared to workers employed in the varnishing depertment (p 0.01). The prevalence of skin symptoms was significantly higher in board preocessing and varnishing departments compared to initial processing department (p 0.05). Occupational asthma and allegic alveolitis were recorded in 3 out of 48 (6.2 p.c.) and 2 out of 48 (4.2 p.c.) workers, respectively. Baseline FVC adn FEV1 values were lower in woodworkers compared to controls (p 0.01). The increased lung function parameters (FVC, FEV1) were observed in woodworkers who smoked compared to non-smokers. The difference was not statistically significant. There was a significant over-shift decrease of all measured spirometric values: FVC, FEV1, FEV1/VC, PEF among woodworkers (p 0.001). There was a significant pre-shift, post-shift decline...


    542/2523

    Tytuł oryginału: Study on the occurrence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV) in ticks collected in Lublin region (eastern Poland).
    Autorzy: Cisak Ewa, Chmielewska-Badora Jolanta, Rajtar Barbara, Zwoliński Jacek, Jabłoński Leon, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.105-110, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: In 114 Ixodes ricinus ticks from 1 district of Lublin region (eastern Poland) exmine by dark field microscopy method, the presence of motile spirochetes, morphologically corresponding to Borrelia species was detected in 8.8 p.c. of the total examined ticks. The highest infection rate was noted among females (16.7 p.c.), much lower in males (7.1 p.c.) and nymphs (4.0 p.c.). Examination of 550 ticks collected from 3 districts of the Lublin region by polymearse chain reaction (PCR) showed that 5.3 p.c. of the total number of ticks were infected with Borrelia spirochetes. The highest rates of Borrelia infection were observed in Ixodes ricinus ticks from the Zamość and Lublin districts (9.6 p.c. and 4.7 p.c. respectively). In the Włodawa district, only 2.4 p.c. ticks showed the presence of Borrelia DNA. In contrast to the results obtained by dark field microscopy method, the highest infection rate was noted in males (11.2 p.c.), followed by females (6.9 p.c.) and nymphs (1.7 p.c.). 57 Ixodes ricinus ticks collected from 3 Lublin districts (Lubartów, Lublin, Radzyń Podlaski) were tested for the presence of tick-borne encephalitis virus (TBEV) by the inoculation of 5-week-old Swiss mice, followed by blind passages and inoculation of GMK cell culture with brain suspension of the infected mice. On strain of TBEV was isolated from a pool of 24 I. ricinus ticks collected from the Radzyń Podlaski district. The minimum infection rate of ticks from this district with TBEV was estimated as 4.2 p.c, and in the total area of Lublin region estiamted as 1.8 p.c.


    543/2523

    Tytuł oryginału: Longterm decrease in the CD57 lymphocyte subset in a patient with chronic Lyme disease.
    Autorzy: Stricker Raphael B., Burrascano Joseph J., Winger Edward E.
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.111-113, tab., bibliogr. 5 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Lyme disease is a tickborne illness caused by the spirochete Borrelia burgdorferi. In a previous report we described a decrease in the CD57 lymphocyte subset in patients with chronic Lyme disease. We have now identified a patient with chronic relapsing and remitting symptoms of Lyme disease who had decreased levels of CD57 lymphocytes over 10 years. This observation represents the longest duration of an immunologic abnormality ever documented in chronic Lyme disease. The CD57 lymphocyte subset appears to be a useful marker of longterm infection with the Lyme disease spirochete.


    544/2523

    Tytuł oryginału: Allergic contact urticaria and rhinitis to roe deer (Capreolus capreolus) in a hunter.
    Autorzy: Śpiewak Radosław, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.115-116, bibliogr. 11 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • immunologia
  • otorynolaryngologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Roe deer (Capreolus capreolus) is one of the most common game mammals in Europe, where hundreds of thousands people are exposed to this antimal. Despite this fact, we are aware of only two cases of allergy to roe deer published until recently, one case of allergic rhinoconjunctivitis and asthma and the second of contact urticaria. We describe another case with co-existing allergic contact urticaria and rhinitis in a 55-year old male professional hunter. The symptoms were provoked only by exposure to roe deer, and there were no other past or present allergic diseases. Specific IgE was found to following animal allergens: cow dander (CAP class 5), goat epithelium and horse dander (each CAP class 4), dog epithelium, dog dander and swine epithelium (each CAP class 2). Skin prick tests have shown positive raction only to cow epithelium (+). Because of lack of deter dander allergen for specific IgE and skin tests, we have confirmed the causal relationship between exposure to roe deer and allergy using the rub test with roe deer's fur. There was a clearly positive urticarial reaction on the patient's skin accompanied by nasal itch, steezing and rhinorrhea. No reaction was seen in a control person. We surmise that the positive tests with cow epithelium seen in this patient may result from a cross-reactivity to deer allergens. We conclude that although occupational allergies to roe deer seem to be rate, such possibility should be always considered among people having contact with these animals.


    545/2523

    Tytuł oryginału: A newly discovered function of palatine tonsils in immune defence: the expression of defensins.
    Tytuł polski: Nowo odkryta funkcja immunologiczna migdałka podniebiennego obrony.
    Autorzy: Weise J. B., Meyer J. E., Helmer H., Wittrock H., Maune S.
    Źródło: Otolaryngol. Pol. 2002: 56 (4) s.409-413, il., tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 313,466

    Hasła klasyfikacyjne GBL:
  • immunologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Migdałek podniebienny niewątpliwie pełni rolę w systemie obrony immunologicznej. Po kontakcie z antygenem uwalniane są limfocyty B i T jako efekt odpowiedzi immunologicznej. Dodatkowo migdałek podniebienny wydaje się wpływać na funkcje obronne poprzez aktywację systemu immunologicznego. Dlatego zbadaliśmy zdolność migdałka podniebiennego do zróżnicowania obrony immunologicznej typu alpha i beta w przewlekłym procesie zapalnym. Wyizolowano RNA pochodzące z 49 hiperplastycznych lub będących w stanie przewlekłego zapalenia migdałków podniebiennych, w których stwierdzono obecność Actinomyces israeli. Przeprowadzono analizę ekspresji genów HNP-1, HNP-4, HBD-1, HBD-2 za pomocą standaryzowanej reakcji glicerynoaldehyd-3-fosfodehydrogenazą po wykonaniu półilościowej PCR. mRNA HNP-1, HNP-4, HBD-1,, HBD-2 zostało wykryte w próbkach tkankowych, lecz ich ilość różniła się w dwóch typach obrony i w tkankach o różnym pochodzeniu. HBD-1 zostało stwierdzone we wszystkich 49 przypadkach przewlekłego zapalenie i w hiperplastycznych migdałkach podniebiennych. Poziom mRNA HBD-2 był istotnie podniesiony tylko w przewlekłym zapaleniu migdałków. Ekspresja mRNA migdałków podniebiennych w różnych typach obrony immunologicznej alpha i beta sugeruje nową funkcję migdałka w systemie odpowiedzi immunologicznej: udział we wrodzonym, nieadaptowanym systemie immunologicznym. Dlatego migdałek podniebienny ma potencjalnie wpływ na wzrost i kontrolę fizjologicznej flory bakteryjnej poprzez swoją ...

    Streszczenie angielskie: The palatine tonsils have an undoubted role in the immune defence system. After antigen contact an effective adaptive immune response aby B-and T-cell lymphocytes will be released. In addition the palatine tonsils seem to exert influence to the defence by the innate immune system. Therefore, we studied the ability of palatine tonsils to express different alpha and beta defencsins and to find out any distinctions in chronic inflamed tonsils. Total RNA of 49 specimens of hyperplastic tonsils and chronic tonsilitis with pathological provided evidence of Actinomyces israelii was islolated using TRIzol protocol, reverse transcribed and the HNP-1, HNP-4, HBD-1 and HBD-2 gene expression densitometric determined, standardised in relation to glycerinaldehyd-3-phosphatdehydrogenase gene expression, after a semiquantitative polymerase chain reaction was performed. mRNA of HNP-1, HNP-4, HBD-2 was detected in tissue samples, but their amount differed within the two defensin families and tissue of origins. HBD-1 was detected in all 49 tissues of hyperplastic tonsils and chronic tonsilitis. Only in chronic inflamed tonsils the amount of HBD-2 mRNA expression was significant increased. In these specimens also mean relative expression rate of all defensins was observed to be manifestly increased. Palatine tonisls express mRNA for different alpha and beta defensins and this expression suggest a newly supposed function in immune defence: the participation in the innate, non-adaptive ...


    546/2523

    Tytuł oryginału: Modulation of the susceptibility of intestinal bacteria to bacteriophages in response to Ag43 phase variation - a hypothesis.
    Autorzy: Węgrzyn Grzegorz, Thomas Mark S.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.HY15-HY18, bibliogr. 38 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Escherichia coli is a Gram-negative bacterium which colonises the intestinal tract of man and other animals. In addition to being a part of the normal bacterial flora of the human intestine, there are a number of enteropathogenic strains of E. coli which cause infections ranging in consequence from diarrhoea to colitis. Antigen 43 (Ag43) is the major phase-variabale protein in the outer membrane of E. coli. One benefit for bacteria resulting from phase variation of surface antigns is usually ascribed to evasion of host defences. However, results of recent studies indicate that infection of E. coli by different bacteriophages is inhibited in the presence of certain bile salts and carbohydrates (components present in the human intestine but absent in standard bacteriological media) when cells are in the "OFF" state for production of Ag43. The inhibition of bacteriophage development was found to be due to a significant impairment in the process of phage adsorption and evidence was presented for the binding of phage to Ag43. Here we present a hypothesis that in the case of Ag43, phase-variation might benefit the host bacterium by modulating the susceptibility to phage infection in the gut. If this hypothesis is true, it may have important implications not only for basic research but also for development of bacteriophage therapy, a re-discovered method of treatment of patients with infectious diseases.


    547/2523

    Tytuł oryginału: Cyclic nitric oxide release by human granulocytes, and invertebrate ganglia and immunocytes: nano-technological enhancement of amperometric nitric oxide determination.
    Autorzy: Stefano George B., Salzet Michel, Magazine Harold I.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR199-BR204, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Various tissues from vertebrates and invertebrates respond to external signal molecules by rapid release of nitric oxide (NO) mediated by constitutive nitric oxide synthase. Invertebrate immunocytes were collected from maintained stock and human granulocytes were isolated from leukocyte-enriched blood obtained from the Long Island Blood Services. The invertebrate ganglionic tissue was either extracted or exposed for ex vivo and in vivo evaluation. Nitric oxide release was measured using a newly developed NO-selective nanoprobe, exhibiting enhanced sensitivity. Evaluation of NO release from the pedal ganglia of the maring bivalve, Mytilus edulis, demonstrated in vitro release of NO that fluctuated from 969 to 1003 pM, with a mean change in NO of 35 pM/cycle and a mean cycle time of approximately 4 minutes. Basal release of NO/cycle from the ganglia in vivo was increased significantly to approximately 65 pM (P 0.05) with an increase in cycle time to approximately 7 minutes. Exposure of the ganglia to morphine in vivo resulted in a significant increase in NO release and a lack of NO pulsations. The fluctuation in NO release from immunocytes of Mytilus edulis was approximtely 27 pM per cycle with a cycle time of 4 minutes whereas human granulocytes release fluctuated approximately 23 pM with a cycle time of 6 minutes. Theses data demonstrate that basal release of NO from various tissues is released in a cyclic manner and the cycle time and magnitude is subject to regulation by external stimuli.


    548/2523

    Tytuł oryginału: Effect of anti-oxidants, free radical quenchers and cyclo-oxygenase inhibitor on benzo(a)pyrene-induced suppression of human lymphocyte mitogenesis in vitro.
    Autorzy: Das Undurti N.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR205-BR207, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Benzo(a)pyrene (BP) is a known carcinogen and immunosuppressor. Activation of BP to its reactive intermediates is cyclo-oxygenase (COX) dependent and occurs via a free radical dependent mechanism. The aim of this study was to know whether anti-oxidants, free radical quenchers and (COX) inhibitor, indomethacin, influence the suppression of human T cells induced by BP in vitro. Human lymphocytes, obtanined from healthy human volunteers, were stimulated to proliferate using phytohaemagglutinin (PHA). The effect of vitamin E. SOD, catalase, mannitol, and COX-inhibitor, indomethacin, on BP-induced suppression of human T cell proliferation was evaluated. Except for catalase, a hydrogen peroxide (H2O2) radical quencher, none of the agents tested could inhibit BP-induced suppression of human T cell proliferation in vitro. BP-induced suppression of human T cell proliferation is probably, induced by increased production of H2O2. Prostaglandins and superoxide anion and hydroxyl redical do not seem to participate in BP-induced human T cell growth suppression.


    549/2523

    Tytuł oryginału: Effects of immunomodulators on acute Trypanosoma cruzi infection in mice.
    Autorzy: Oz Helieh S., Hughes Walter T., Thomas Elaine K., McClain Craig J.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR208-BR211, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Patients who recover from acute trypanosomiasis may succumb to chronic Chagas' disease later in life due to age related immunosuppression, immune system disorders such as AIDS, or during periods of immunosuppressive therapy for organ transplantation. In this study, effects of immunomodultors with diverse properties were examined on the course of an acute and lethal Trypanosoma cruzi infection. ICR (Swiss) mice inoculated with Tulahuen (lethal) strain of T. cruzi were treated with 6 different immunomodulators and the course of infection was studied. Tacrolimus (FK-506) and dexamethasone increased parasitemia in mice when compared to infected untreated animals. Mycophenolate mofetil (RS-61443) ana recombinant interleukin-15 (IL-15) treatment decreased the number of parasites but had no effect on animal survival. In contrast, compound L-685-818 (tacrolius analog) and CD40 ligand (CD40L), provided protection against lethal infection. Mice that survived initial infection were all protected against reinfection. This study demonstrates the dangers of immunosuppression with tacrolimus and dexamethasone in T. cruzi infected subjects. While mycophenolate did not exacerbate the infection, our data suggest potential therapeutic applications for L-685-818 and CD40 ligand in trypanosomiasis.


    550/2523

    Tytuł oryginału: Chemoprotection profiles of sodium thiosulfate on methyl methanesulfonate-induced mutagenesis of bacteriophage T4.
    Autorzy: Malik Ajmaluddin, Khan Asad Ullah, Lal Sunil Kumar
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR212-BR220, il., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The alkylation of nucleic acids is primarily responsible for chemical carcinogenesis. Even during disease treatment, several alkylating drugs interact with nucleic acids and cause severe toxic effects. Thus good chemoprotectants are necessary. For our study we chose a simple model organism, bacteriophage T4 (a nucleoprotenic particle), and alkylating agent methyl methanesulfonate (MMS) to study its lethal effects. Sodim thiosulfate (STS), used as a chemoprotectant, has been tested against alkylating drugs. Bacteriphage T4Do were exposed to different molarities of MMS for several pre-termination incubations. Alkylation reactions were stopped with different concentrations of STS at given pre-termination incubation periods and further incubated up to 24 hours. The viability (survival frequency) of phage T4 was studied at various post-termination intervals by plaque count assay. Our results show that the survival frequency is strongly influenced by MMS dosage and exposure time. However, the antidotal effect of STS on MMS-induced lethality directly corresponds to STS dosage. Survival frequencies with 1 p.c. quench solution were lower than with 5 p.c. quench solution at all molarities of MMS and at different pre-and post-termination periods. Our studies confirmed the role of STS in the cytoprotection of bacteriophage T4. In the presence of 1 p.c. STS, a moderate inhibition in cytotoxicity was observed, while 5 p.c. STS exhibited a significant inhibition against the cytotoxic activity of MMS, presumably due to a rapid covalent binding of the methyl group (carbocation - an electrophile ) of MMS with the nucleophilic sulfur atom of STS.


    551/2523

    Tytuł oryginału: Human leptin administered intraperitoneally stimulates natriuresis and decreases renal medullary NA+, K+-ATPase activity in the rat - impaired effect in dietary-induced obesity.
    Autorzy: Bełtowski Jerzy, Wójcicka Grażyna, Górny Dionizy, Marciniak Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR221-BR229, il., bibliogr. 37 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Leptin, produced by adipose tissue, apart from regulating food intake and energy expenditure, also has natriuretic activity. In this study we examined the effect of leptin on renal Na+, K+-ATPase responsible for active tubular sodium reabsorption, and compared the renal effects of leptin in lean and obese rats. Male Wistar rats were either kept on normal laboratory chow or made obese by a high-calorie diet. The animals were placed in metabolic cages and urine was collected in 2-hour periods. In lean animals, leptin (1 mg/kg i.p.) caused a 139.5 p.c. increase in uring output, a 112.4 p.c. increase in natriuresis, and a 57.2 p.c. increase in the fractional excretion of sodium, but had no effect on the glomerular filtration rate. Leptin at this dose decreased renal medullary Na+, K+-ATPase activity at 30 minutes, 1 hour and 2 hours by 31 p.c., 34.3 p.c. and 21.2 p.c., respectively. The effect of leptin on Na+, K+-ATPase at 1 hour was dose-dependent; the lowest dose inducing significant inhibition was 0.25 mg/kg. By contrast, leptin had no effect on either cortical Na+, K+-ATPase or the ouabain-resistant fraction of ATPas. In obese rats, leptin increased urine output by only 29.1 p.c. and natriuresis by 28.9 p.c., and had no significant effect on medullary Na+, K+-ATPase. Leptin stimulates natriuresis primarily by inhibiting tubular sodium reabsorption. This effect is mediated, at least partially, by decreased Na+, K+-ATPase actaivity in the ranal medulla, and is impaired in obese rats.


    552/2523

    Tytuł oryginału: Human cytomegalovirus infection and abortion: an immunohistochemical study.
    Autorzy: Spano Liliana Cruz, Pereira Fausto Edmundo Lima, Basso Nadia Gomes da Silva, Mercon-de-Vargas Paulo Roberto
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR230-BR235, il., tab., bibliogr. 50 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cytomegalovirus (HCMV) has been described in abortion tissues, but seldom associated with inclusion bodies. However, the possible pathogenic role of this virus in aborton is under discussion. We attempted to verify the realtionship between HCMV antigens in tissues from first trimester abortions presenting with inflammatory lesions. Sixteen cases of first trimester abortions with inflammatory lesions were selected from 340 cases studied at the Pathology Unit of the University Hostoptal in Vitória, Espirito Santo State, Brazil. Paraffin-embedded sections were subjected to indirect immunofluorescence (IFI) and immunoperoxidase (PAP), using monoclonal antibodies directed against immediate early (IEA) and late antigens (LA) of HCMV. Twelve out of sixteen cases (75 p.c.) presented at least one HCMV antigen. Eight cases presented both antigens, three cases only the IEA and one case only the LA. These antigens were present in decidual cells, in stromal cells of chorionic villi and in trophoblastic cells. The results showed high frequency of HCMV antigens in tissues from first trimester abortion. This frequency, higher than that previously reported, was probably due to the fact that necroinflammatory lesions were always present in selected cases. The presence of LA in trophoblastic cells is evnce for cell permissiveness to viral replication in vivo. The results showing high presence of HCMV antigens in tissues from abortion with inflammatory lesions suggest a possible relationship of HCMV infection with inflammation and pregnancy loss.


    553/2523

    Tytuł oryginału: Effect of ambroxol on ion transport - a model study.
    Autorzy: Kosik-Bogacka Danuta I., Tyrakowski Tomasz
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR236-BR241, il., tab., bibliogr. 44 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Żaby

    Streszczenie angielskie: Effect on ambroxol on reflexive physiological reactions of isolated frog skin was studied with elctrophysiological methods designed to assess on currents occurring in epithelial tissues or organs. The experiments permitted to analyze an effect of ambroxol on regulatory mechanisms, which in turn influence the constant electrical potential defined as PD and reversible changes of this potential during mechanical stimulation (marked as dPD). A contribution of sodium- and chlorid eions transport to the value of transepithelial electrical potential of frog skin (before adn after ambroxol administration) has been demonstrated using amiloride - a blocker of sodium ion transport and bumetanide - a blocker of chloride ion transport. The experimental material comprised 34 fragments of hybrid frog (Rana esculenta L.),, representing 14 spcimens. The experiments involved measuring the transepthelial electrical potential (PD in mV) on an isolated frog skin place in an Ussing apparatus. It has been demonstrated that ambroxol influences the processes of ion transport (dPD) which in turn depend on mechanical stimulation. The reaction of hyperpolarization decreased immediately after administration of ambroxol to the stimulating fluid, when transepithelial transport of sodium ion was maintained in the preparations studied. Consequently, no efect of ambroxol on the frog skin incubated wtih amiloride was recorded. It has been demonstrated, based on the experiments carried out in the present study , taht ambroxol can modify processes of ion transport related to activation of sensory receptors...


    554/2523

    Tytuł oryginału: Intervention in patients with pneumothorax immediately following CT-guided fine needle aspiration of pulmonary nodules.
    Autorzy: Shantaveerappa Harsha N., Mathai Mathew G., Byrd jr Ryland P., Karnad Anand B., Mehta Jayant B., Roy Thomas M.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR401-CR404, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The incidence of pneumothorax (PTX) as a complication of computerized tomography guided fine needle aspirates (CT-FNA) of solitary pulmonary nodules (SPN) varies from 8 - 61 p.c. It has been suggested that the practice of obtaining a delayed chest radiograph in patients who have undergone CT-FNA of SPN is not cost effective and adds little information concerning lung expansion obtained by CT and the end of the procedure. It, however, is not known what percent of patients with a PTX present immediately after CT-FNA but do not require prompt chest tube placement will progress and require intervention later. One hundred-fifty-eight consecutive patients undergoing CT-FNA of SPN were included in the study. Immediately after CT-FNA each patient was reimaged with the CT scanner to checka for PTX. Patients with a PTX immediately after CT-FNA were assessed as to whether intervention was undertaken or whether the PTX enlarged and/or required drainage at a later time. Thirty-eight patients developed a PTX while still on the CT scanner. Twenty-nine patients with an immediate PTX did not require drainage of their pleural space. Chest tube placement was required prompty after the CT-FNA in 4 patients. Five patients had their pleural space drained at a later time due to an increasing size of the PTX and/or the development of symptoms attributed to the PTX. These data suggest that patients who develop a PTX immediately after CT-FNA but who do not require prompt pleural space evacuation should be followed closely both clinically and radiographically.


    555/2523

    Tytuł oryginału: Dyspnea scales as a measure of health-related quality of life in patients with idiopathic pulmonary fibrosis.
    Autorzy: Martinez Jose Antonio Baddini, Martinez Tieko Yamamoto, Galhardo Fabiola Paula Lovetro, Pereira Carlos Alberto de Castro
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR405-CR410, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease and is usually associated with a poor prognosis. IPF patients have a significant impairment in health-related quality of life (HRQL), both in terms of physical and psychological functioning. A substantial number of dyspnea scales are available to clinicians for clinical and research use. The objective of the present study was to investigate how some commonly used dyspnea scales correlate with measurements of HRQL in IPF patients. A group of 30 patients with IPF who attended a specialized outpatient respiratory clinic were interviewed during a stable period of the disease. HRQL was assessed by the SF-36 questionnaire. Dyspnea was measured by the baseline dyspnea index (BDI), Modified Medical Research Council Scale (MRC), Oxygen Cost Diagram (OCD), clinical element of the Clinical, Roengenographic and Physiologica score (CRP), and a new dyspnea scale (NS) based on estimates of required oxygen consumption for usual activities. Patients showed impariments in all HRQL domains except the Pain Index. All dyspnea scales showed significant correlations with both physical and mental HRQL domains. The highest Spearman's coefficients between dyspnea ratings and SF-36 components were obtained using the BDI. Dyspnea ratings correlate with HRQL measurements in IPF patients. Dyspnea scales can be used as a measure of HRQL in special circumstances.


    556/2523

    Tytuł oryginału: Further arguments against including trisialo-Fe2-transferrin in carbohydrate-deficient transferrin (CDT): a study on male alcoholics and hazardous drinkers.
    Autorzy: Arndt Torsten, Korzec Aleksander, B„r Marij, Kropf Jrgen
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR411-CR418, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We attempted to determine whether including trisialo-Fe2-transferrin in carbohydrate-deficient transferrin (CDT) affects the diagnostic accuracy of CDT as a marker of chronic excessive alcohol intake. The criterion standard tests for the diagnosis of alcoholism and alcohol intake were the Composite International Diagnostic Interview (CIDI) and the Timeline-Followback (TLFB). The study groups (alcohol intake in each of the last 4 weeks before blood sampling) were comprised of 56 controls (ó 280 g/week, no alcoholism), 54 hazardous drinkers ( 280 g/week, no alcoholism), 63 alcoholics ( 280 g/week, alcoholism diagnosis). CDT analysis was performed with p.c.CDTri-TIA, which includes about 50 p.c. of trisialo-Fe2-transferrin in CDT, and ChronAl-col. D, which excludes this transferrin isoform from CDT. Depending on the cut-offs for the CTD/transferrin ratio (upper or lower limit of the test-specific borderlines) and on the patient group, the diagnostic sensitivity was 18.1 p.c. - 72 p.c. for p.c.CDTr-TIA, as opposed to 50.p.c. - 82.5 p.c. for ChronAlcol.D. The diagnostic accuracy was 62.8 p.c. - 78.5 p.c. for p.c.CDTri-TIA and 71.8 p.c. - 86.6 p.c. for ChronAlcol.D. The latter test consistently showed higher diagnostic sensitivity and accuracy than p.c. CDTri-TIA. The diagnostic specificity was 85.7 p.c. - 98.2 for p.c.CDTri-TIA and 91.1 p.c. - 92.2 p.c. for ChronAlcol.D. The areas under the ROC curve were 0.810 p.c. - 0.885 for p.c.CDTri-TIA and 0.867 p.c. - 0.896 for ChronAlcol.D. The present study and data from the literature indicate that including parts of trisialo-Fe2-transferrin by the p.c. CDRri-TIA test significantly reduces the diagnostic sensitivity and thus accuray of CDT as a marker of chronic excessive alcohol use.


    557/2523

    Tytuł oryginału: Oxidative stress in the blood of patients with alcohol-related liver cirrhosis.
    Autorzy: Szuster-Ciesielska Agnieszka, Daniluk Jadwiga, Kandefer-Szerszeń Martyna
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR419-CR424, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Ethanol may increase the production of reactive oxygen species (ROS) in the liver, which results in the development of alcoholic liver disease (ALD). Cytokine-acitvated blood leukocytes may also participate in this process. The aim of our study was to evaluate the oxidative stress level in the blood of patients with alcoholic liver cirrhosis. Blood neutrophils from 16 patients with compensated alcoholic liver cirrhosis and 28 patients with decompensated were evaluated for their ability to produce superoxide anion and hydrogen peroxide spontaneously and after PMA induction, in comparison to controls (16 healthy persons). Serum catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity were also measured in both groups of patients and in the controls. The neutrophils from patients with compensated liver cirrhosis spontaneously produced a normal level of Oz- and a high level of H2O2, but exhibited a defect in PMA-induced O2- production. The neutrophils from patients with decompensated liver cirrhosis spontaneously produced more O2- adn H2O2 than the controls, but the PM response was weak. There were no changes in the expression of GPx, buth enhanced SOD activity was observed in the serum of patients with decompensated alcoholic liver cirrhosis. Increased CAT activity was detected only in serum from patients with compensated liver cirrhosis. These data point to oxidative stress in the blood of patients with decompensated alcoholic cirrhosis, since increased resting production of ROS in neutrophils was not accompanied by increased GPx and CAT activity in serum.


    558/2523

    Tytuł oryginału: Atherosclerosis risk factors in children and adolescents with or without family history of premature coronary artery disease.
    Autorzy: Kelishadi Roya, Zadegan Nizal Sarraf, Nadery Gholam Ali, Asgary Sedigueh, Bashardoust Nasrollah
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR425-CR429, tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Although coronary artery diseases (CAD) becomes symptomatic much later in life, the early identification and modification of risk factors may reduce its later incidence. 100 subjects 2 - 18 years old, evenly divided by sex, were randomly selected from among children of patients suffering from premature myocardial infarction ( 55 years); the controls were 100 age- and sex-matched subjects without a similar family history. In the Pediatric Preventive Cardiology Clinic at the Isfahan Cardiovascular Research Center, the subjects completed a special questionnaire consisting of anthropometric data, blood pressure, skinfold thickness, rate of physical activity, and active or passive cigarette smoking. Fasting venous blood was analyzed for serum lipids, lipoproteins fibrinogen, and apolipoproteins A1 and B100. The data were analyzed with SPSS V6/vin using the independent t-test, Kruskal-Wallis, chisquared, and standard linear multiple regression tests. The data showed higher prevalence of some major and new risk factors in the experimental group than in the controls. The mean total cholesterol, LDL-C, TG, fibrinogen and Apo B100 were significantly higher in the experimental group, while the mean values of HDL-C and Apo A1 were significantly lower. The differences in terms of Body Mass Index, percentage body fat, rate of regular physical activity, and active and passive smoking were not significant between groups. Major and new CAD risk factors should be identified and modified as early as possible in children with high family risk by screening and health education at an early age.


    559/2523

    Tytuł oryginału: The renin-angiotensin-aldosterone system (RAAS) and its relation with calcium homeostasis in male obesity.
    Autorzy: Ozata Metin, Durmus Oziem, Yilmaz Mahmut Ilker, Bolu Erol, Erdogan Murat, Ozdemir I. Caglayan
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR430-CR433, tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: The aim of our study was to determine whether alterations of the vitamin D-endocrine system and the renin-angiotensin-aldosterone system occur in male obesity and influence each other. 32 ibese male subjects and 21 age-matched healthy male subjects were enrolled in the study. The parameters measured included serum total calcium (Ca), ionized calcium, magnesium (Mg), phosphorus (P), 25-hydroxyvitamin D (25-OHD), supine and upright aldosterone and renin activity, and urinary calcium, magnesium, and phosphorus. Serum total Ca and ionized calicum were slightly, but not significantly lower in obese subjets compared to controls, whereas serum magnesium phosphorus and PTH levels were significantly higher in the obese subjects. Mean urinary calcium and Mg were not significantly different, while urinary P was significantly higher in obese subjects. Mean serum 25OHD was significantly lower in obese subjects. Supine and upright aldosterone and renin were unrelated to BMI or fat mass. Supine aldosterone correlated with serum total calcium, ionized calcium and supine renin activity, but not with other minerals, PTH or 25OHD, whereas upright aldosterone did not correlate with other parameters. Supine renin activity did not correlate with any parameters, whereas upright renin correlated with serum Mg an PTH. There were significant correlations between PTH and BMI or fat mass. Urinary Mg was also related to both BMI and fat mass. Male obesity is associated with increased serum Mg, P, PTH and urinary P and lower supine aldosterone and 25OHD, but unchanged serum and urinary Ca.


    560/2523

    Tytuł oryginału: Symptomatic annular pancreas in newborns.
    Autorzy: Sencan Aydyn, Mir Erol, Gnsar Cneyt, Akcora Blent
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR434-CR437, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki

    Streszczenie angielskie: The pancreas exhibits various types of anomalies, including aplasia, dysplasia, pancreatc cysts, duplication, and ectopis, of which the most common is annular pancreas. This stdy describes the characteristic features of 7 cases of annular pancreas diagnosed during exploration. Seven newborns undergoing surgery for annular pancreas from 1990 to 1998 were analyzed. The cases were evaluated according to birth weight, sex, symptoms, methods of diagnosis, associated anomalies, and surgical treatment modalities. The mean birth weight of the patients was 2385 ń 1002 g, the mean gestational age was 37.5 3.1 weeks. Four patients (42.8 p.c.) had associated anomalies, including intestinal malrotation (42.8 p.c.), intrinsic duodenal obstruction (28.5 p.c.), trisomy 21 karyotype (14.2 p.c.), cardiac malformation (14.2 p.c., and Meckel's diverticulum (14.2 p.c.). Surgical treatment included denoduodenostomy (DD) in four patients and DD plus tapering enteroplasty (TE) plus placement of transanastomotic jejunal tube (TJT0 in three patients. Infants with annular pancreas associated with duodenal obstruction are generally premature or small for their gestational age. The symptoms observed in annular pancreas ate related not only to extrinsic compression of the ectopic tissue, but also the duodenal stenosis associated with this malformation. Annular pancreas is most commonly associated with intestinal atressias, and oral feeding tolerance time is nearly the same between the DD and DD+TE+TJT groups.


    561/2523

    Tytuł oryginału: Extrahepatic bile duct injury during laparoscopic cholecystectomy - a survey of 6873 patients.
    Autorzy: Paczyński Andrzej, Koziarski Tomasz, Stanowski Edward, Krupa Jarosław
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR438-CR440, bibliogr. 8 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Despite recognised advantages of laparoscopy, the damage of extrahepatic bile ducts during cholecystectomy is a subject of ongoing discussions, as such injuries are more frequent comparing with open surgery. The analysis included 6873 patients who underwent laparoscopic cholecystectomy. The study group comprised both the patients after elective surgery due to symptomatic cholelithiasis and patients after emergency procedures necessiated by acute cholecystitis. Common bile duct was damaged in 9 patients. Five people had their main bile duct transected, in 2 people it was partial excision, and in the other 2 subjects - puncture damage with electrocoagulation took place. In seven cases, the damage was diagnosed still during laparoscopy and conversion to open surgery was performed. In two subjects the damage was diagnosed in postoperative period and it was subsequently confirmed by ERCP. Roconstructive surgery included: BCD suturing with interrupted stiches, end-to-end anastomosis over T-tube and Roux-en-Y bilioenteric anastomosis. Good postoperative outcome was obtained in 6 patiens. One subject required repeated endoscopic dilatation and placement due to recurrent cholangitis. Two patients died due to upper gastrointestinal bleeding and multiple organ failure. Extrahepatic bile duct injury remains a dangerous complication following cholecystectomy. It is more likely to occur in case of anomalous anatomy of bile ducts, inflammatory or malignant infiltration and technical errors of an operating surgeon. It is very important to diagnose the damage early enough, preferably still during laparoscopy. Imaging investigations (ultrasound, ERCP, MRCP, cholangiography) may be helpful in establishing the diagnosis during the postoperative period.


    562/2523

    Tytuł oryginału: Apoptosis and pH of blasts in acute childhood leukemia.
    Autorzy: Malinowska Iwona, Stelmaszczyk-Emmel Anna, Wąsik Maria, Rokicka-Milewska Roma
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR441-CR447, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The purpose of our study was to determine whether spontaneous and post-initial therapy apoptosis indexes (AI) and the intracellular pH of blasts have prognostic value in the treatment of children with acute leukemia. Blasts from 38 children with acute leukemia (31 with ALL and 7 with AML) were tested for apoptotic index (Annexin V) and intracellular pH (SNARF). Of the ALL patients, 9 were low risk, 7 medium risk, and 15 high risk. Among the AML patients, 1 was low risk and 6 were high risk. Follow-up ranged from 6 to 120 weeks (median 60 weeks). The maen spontaneous AI was 19 ń 16 p.c. The pH of leukemic blasts before treatment varied between 6.6 and 7.9 (mean 7.2 ń 0.5). For patients 10 years old, the markers for good prognosis were a WBC count below 50 x 10**3/ćl, good response to prednisone therapy at day 8, and remission at or before day 33. Univariate analysis showed that pH 7 had favorable prognostic significance. Overall, the probability of EFS for patients with pH 7 was 1.0, as opposed to 0.49 for those with pH 7 (p = 0.049, n = 36). The probability of EFS for patients with AI below the median was not significantly different from those with AI above the median (0.4 vs 1.0, NS). The assessment of intracellular pH in blasts may be an important prognosticator for ALL patients. Children with low spontaneous ALL or high pH of leukemic blasts appear to have an unfavorable prognosis.


    563/2523

    Tytuł oryginału: Pathological somatosensory evoked potentials in patients with hypertension: a contribution to the study of the pathophysiology of juvenile essential hypertension.
    Autorzy: Varsik Pavel, Buranova Darina, Balaz Marek, Duris Ivan
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR448-CR452, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The role of factors influencing the cerebral regulation of blood pressure must be considered in the etiopathogenesis of essential hypertension. The aim of our work was to ecplore the possibilities for differentiating certain clinical, functional and electrophysiological signs in young and adult hypertensives. This could help us to determine whether centrally active antihypertensive drugs may be more suitable than others. We examined somatosensory evoked potentials (latencies of wave deflections and amplitudes) in two groups of patients with essential hypertension. The first group consisted of 25 hypertensive patients aged 20 to 30 years with onset before age 20 (n = 25). The second group consisted of 40 hypertensive patients aged 40 to 60 years with onset after the age of 30. The results were compared with those obtained from age-correlated healthy controls. The most interesting changes were observed in the amplitudes of somatosensory evoked potentials in the group of juvenile patients with hypertension. The decrease in the amplitude of all wave deflections was very compact, consistent, and statistically significant even after repeated examinations. This finding raises the possibility of influence or damage to the peripheral afferentation of signals inuvenile patients, with hypertension as an expression of the actions of brainstem structures. Our results suggest that afferent impulses and the reactivity of brainstem structures may play a role in the etiopathogenesis of hypertension.


    564/2523

    Tytuł oryginału: Incidence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in the province of Denizli, Turkey.
    Autorzy: Keskin Nazan, Ozdes Ibrahim, Keskin Ali, Acikbas Ibrahim, Bagci Huseyin
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR453-CR456, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: G6PD deficiency is a widespread abnormality of glucose-6-phosphate dehydrogenase, a red cell enzyme, which gives rise to hemolysis under oxidative stress. In Turkey, G6PD deficiency has a variable frequency in different regions. The prevalence and genotypes of G6PD deficiency are not known in Denizli province of the Aegean region of Turkey. Accordingly, this study was designed to investigate the prevalence of enzyme deficiency and the distribution of the Mediterranean mutation of G6PD in this region. A total of 1950 students (918 females, 1032 males, ages between 14 and 17) were screened by the Fluorescent Spot Test, and the G6PD deficiency was confirmed by quantitative spectrophotometric assay. The G6PD deficient subjects were further analyzed by the PCR/RFLP technique to identify the presence of the 563 T Mediterranean mutation. 24 of the subjects wre found to be deficient in this enzyme, a frequency of 1.23 p.c. Of 24 deficient subjects, 19 (79 p.c.) had the 563 T Mediterranean mutation. The frequency of G6PD enzyme deficiency apperars to be low compared with those found in the malaria-endemic Mediterranean region of Turkey. The molecular pathology of G6PD deficiency is related to the G5PD-563 T mutation in the Denizli region.


    565/2523

    Tytuł oryginału: Does the negative correlation found in breast cancer patients between plasma melatonin and insulin-like growth factor-I concentrations imply the existence of an additional mechanism of oncostatic melatonin influence involved in defense?
    Autorzy: Kajdaniuk Dariusz, Marek Bogdan, Kos-Kudła Beata, Żwirska-Korczala Krystyna, Ostrowska Zofia, Buntner Barbara, Szymszal Jan
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR457-CR461, il., tab., bibliogr. 54 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Insulin-like growth factor-I (IGF-I) is probably involved in promoting both normal and neoplastic cell growth, neoplastic transformation processes, angiogenesis, and neoplasma progression. On the other hand, one possible mechanism of the oncostatic action of melatonin is its influence on the action and/or release of teh growth factors that stimulate neoplastic cell growth. Quantitative changes in melatonin and IGF-I, as well as an imbalance between melatonin and IGF-I, may affect the growth of breast cancer cells and exacerbate the disease. The aim of our research was to study the interactions between plasma melatonin and IGF-I concentrations in pre-menopausal breast cancer patients. Our research involved 24 breast cancer patients (mean age 43 ń 6) with stage II breast cancer (Bloom and Richardson classification), confirmed by histological studies, and were 4 weeks after radical mastectomy. The control group consisted of 16 healthy women wolunteers (mean age 44 ń 5). No statistically significant relations were found between mean plasma melatonin and IGF-I concentrations in the two study groups. In the breast cancer group the correlation coefficient between IGF-I concentration in plasma and melatonin was r = -0.058). The negative correlation between the plasma melatonin and IGF-I concentrations in the breast cancer patients we studied could rach statistical significance in a larger population. The presence of such a negative correlation between plasma melatonin and IGF-I concentrations in patients with neoplastic disease may imply the existence of an additional defense mechanism based on the oncostatic influence of melatonin.


    566/2523

    Tytuł oryginału: Presentation of intracranial arachnoid cysts in children: correlation between localization and clinical symptoms.
    Autorzy: Mazurkiewicz-Bełdzińska Maria, Dilling-Ostrowska Ewa
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR462-CR465, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Ther present study was performed in order to determine the most common neurological signs of arachnoid cysts (AC) in a pediatric population and to evaluate if there is a correlation between the localization of the cyst and the clinical characteristics. Forty-five AC patients were studied, aged 2 - 17 years, who were consecutively referred to the Department of Developmental Neurology at the Medical University of Gdańsk between 1990 - 2001. We found that AC has a strong predilection to the temporal regions and was associated with epilepsy in 31 p.c. of the cases. The patient's main complaint, however, was headache (in 69 p.c. of casefs). In 6 cases AC required surgical treatment, because of intracranial hypertension. The AC concomitant with epilepsy had a significant prodilection to the left temporal region (92 p.c. of cases).


    567/2523

    Tytuł oryginału: Cardiotoxicity following different doses and schedules of 5-fluorouracil administration for malignancy - a survey of 427 patients.
    Autorzy: Tsavaris Nicolas, Kosmas Christos, Vadiaka Maria, Efremidis Michalis, Zinelis Andreas, Beldecos Dimitris, Sakelariou Dimitris, Koufos Christos, Stamatelos George
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.PI51-PI57, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Although cardiotoxicity associated with 5-Fluorouracil (5-FU) administration is infrequent, there are case reports of acute coronary syndromes. We report on patients undergoing 5-FU chemotherapy who developed cardiac symptoms during its administration. In patients receiving 5-FU who experienced cardiac-related symptoms, ECG and serum cardiac enzyme determination were performed. If cardiotoxicity was detected, 5-FU infusion was interrupted, and the patients received sublingual nitrates and caradiac monitored in a coronary care unit for at least 72 hours. In cases of acute myocardial infarction, 5-FU was terminated Of 427 patients entering the study, 17 (4 p.c.) developed clinical symptoms and ECG abnormalities indicating 5-FU cardiotoxicity. Patients with continuous infusion (c.i.) of 5-FU had a higher incidence of cardiotoxicity (12/197, 6 p.c.) than the remaining (5/235, 2.1 p.c.) (p = 0.067), but more toxicity was enccountered in patients with c.i. of 5-fu + LV for 24 hours for 5 days than in patients with the same regimen of 5-FU without LV (p 0.027) or patients with short 5-FU + LV administration (p = 0.024). Seven of the 17 patients with 5-FU cardiotoxicity had an acute myocardial infarction, 4 developed ischemic changes, while 4 more patients had ECG abnormalities consistent with coronary vasospasm, of whom one subsequently died. The present study supports the toxic effect of 5-FU on myocardium which is largely schedule-dependent. Considerable vigilance is required when usnig this drug, and its toxic effect on the coronary endothelium and myocardium merit further investigation.


    568/2523

    Tytuł oryginału: Salvage chemotherapy with the gemcitabine/docetaxel combination in non-small cell lung cancer: an overview of recent phase II studies.
    Autorzy: Kosmas Christos, Tsavaris Nicolas, Kalofonos Haralambos P.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.PI58-PI63, tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Docetaxel has been the only single agent with proven activity and documented survival benefit in the second-line treatment of advanced/refractory non-small cell lung cancer (NSCLC). Combinations of docetaxel with other active agents in this setting, such as gemcitabine, besides their popularity as front-line treatment, are currently being explored in an attempt to improve the results over single-agent docetaxel in relapsed/refractory NSCLC. Given the established activity of single-agent decetaxel in two recent large randomized phase III trials against best supportive care or versus single-agent Vinorelbine or Ifosfamide in patients with platinum pretreated NSCLC, and the proven activity of single-agent gemcitabine in this setting, combination regimens employing these two agents in various doses and schedules have recently been initiated. Adequately designed phase II studies using standard criteria of efficacy and safety, which peer-review based publication, were selected from the literature. The gemcitabine/docetaxel combination regimens employing these two agents in various doses and schedules have recently been initiated. Adequately designed phase II studies using standard criteria of efficacy and safety, with peer-review based publication, were selected from the literature. The gemcitabine/docetaxel combination in various schedules with or without G-CSF support as salvage therapy of NSCLC pre-treated with platinum + paclitaxel - based regimens has been evaluated in four recently published phase II clinical studies, and has been shown to represent a tolerable and active regimen in this setting, yielding a 10 - 33 p.c. response rate, improvement of disease-related symptoms, and meaningful median and 1-year survival figures in the...


    569/2523

    Tytuł oryginału: Case presentation of gastrinoma combined with gastric carcinoid with the longest survival record - Zollinger-Ellison syndrome: pathophysiology, diagnosis and therapy.
    Autorzy: Konturek Stanisław J., Konturek Piotr C., Bielański Władysław, Lorens Krzysztof, Sito Edward, Konturek Jan W., Kwiecień Sławomir, Bobrzyński Andrzej, Pawlik Teresa, Karcz Danuta, Areny Hany, Stachura Tomasz
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CS43-CS59, il., bibliogr. 129 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Zollinger-Ellison syndrome is a very rare disease caused by tumor with gastrin producing cells accompanied by hypergastrinemia leading to gastirc hypersecretion and peptic ulcers and their complications. Female case of gastrinoma (Zollinger-Ellison syndrome; Z-E) with a record of 38 yrs of survival. Acute gastro-duodenal ulcers started at 28 yr of age and Z-E was diagnosed by using gastrin assays. Basal and maximal acid outputs and ratio of basal/maximal outputs were away over normal limits. Because of ulcer recurrence and complications, patients was subjected to several gastric surgeries but refused total gastrectomy. She was also treataed with many H2-receptor (R) antagonists and proton-pump inhibitors (PPI), each new drug being initially highlyt effective but then showing declinig efficacy except when PPI, lansoprazole was used. The gastrin level rose in the course of disease from initial high value of 2000 pg/mL to the extreme 4500 ng/mL at present. During the last 2 yrs, metastasis mainly to liver developed and they were successfully treated by synthetic octapeptided derivative of somatostatin and, as a result, metastatis partly reduced and plasma gastrin drasticly decreased. Biopsy taken from liver metastasis showed the presence of typical gastrinoma cells with gastrin and chromogranin, while that from oxyntic mucosa revealed the ECL-cell hyperplasia with corcinoid tumors and unexpected gastric atrophy. This phenomenal case described in this article might be the new proven evidence needed by gastroenterologists to overturn the traditional treatemnt using total gastrectomy as a treatment of choice to the partial gastrectomy combined with proton pump inhibitors.


    570/2523

    Tytuł oryginału: General model to describe the structure and dynamic balance between different human serum lipoproteins and its practical application.
    Autorzy: Tuzikov Fedor V., Tuzikova Nataliya A., Galimov Ravil V., Panin Lev E., Nevinsky Georgy A.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT79-MT88, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Many dangerous diseases are associated with changes in the concentration of blood lipoiproteins (LPs). Thus a fast and accurate method is needed to determine the composition of lipoprotein fractions in human serum. A comparison of 30 parameters characterizing different LPs in serum from 120 healthy donors and 102 multiple sclerosis patients was carried out using a unique algorithm developed to determine the concentrations of all the main lipids and apolipoproteins in each LP fraction and subfarction. Specially developed computer programs and the small-angle X-ray scattering (SAXS) method were used to analyze the literature and experimental data. A general mathematical model has been developed to descrie the structure and equilibrium between various LPs, from high density to chylomicrons. All human serum LPs can be regarded as spherical particles, composed of a lipid hydrophobic spherical core consisting of triglycerides and cholesterol esters, and a hydrophilic shell of free cholesterol, phospholipids and apolipoproteins. We show for the first time that the distribution of components among various LP particles can be described by a system of five basic equations and two additional balance equations. The observed difference between control subjects and MS patients was found to be statistically significant in 23 parameters. In contrast to traditional methods the new method for analyzing human blood LPs is very simple and relatively quick. LP - lipoproteins; HDL - high density lipoprteins; LDL - low density lipoproteins; VLDL - very low density lipoproteins; CM - chylomicrons; TG - triglycerides; FC - free cholesterol; CE - cholesterol ester; PL - phospholipids; P - apolipoproteins; LPL - lipoproteinlipase; H-TGL - hepatic triglyceridlipase; DLP - dyslipoproteinemia; SAXS - small-angle X-ray scattering.


    571/2523

    Tytuł oryginału: 18 F-Fluorodeoxyglucose triple-headed coincidence detection imaging in oncology: preliminary results and comparison with dedicated PET.
    Autorzy: Winter Frederic De, Wiele Christophe Van de, Vandenberghe Stefaan, Vandenbossche Bieke, D'Asseler Yves, Huglo Damien, Dierckx Rudi
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT89-MT94, il., tab., bibliogr. 2 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Dual head coincidence (DHC) imaging has been proposed as a valuable and cheaper alternative to oncological PET. The increased sensitivity of the recently-developed triple-headed gamma camera (THC) optimized for coincidence detection has not been either validated or compared to the sensitivity of a dedicated PET system in a clinical study. Differences in contrast-to-noise-ratio (CNR) between dedicated FDG PET, DHC and THC imaging were assessed using a hot sphere phantom. Twenty-two oncological patients were prospectively studied with consecutive whole body FDG PET adn FDG THC imaging. The images were visually read by 2 experienced nuclear medicine specialists. The diagnostic sensitivity of FDG THC imaging was assessed using FDG PET as the imaging gold standard. Lesion size was determined using computed tomography or magnetic resonance imaging. The mean gain in CNR for THC as compared to DHC imaging was 35 p.c. (10 - 56 p.c.). Of 63 lesions, 58 (92 p.c.) on FDG PET were also detected wtih THC imaging. Considering only lesions smaller than 15 mm, the relative sensitivity was 86 p.c. (24.29). All lesions aboe 15 mm (n = 34) were detected using THC imaging. The first clinical results for THC imging are promising. The overall relative sensitivity in this limited series was 92 p.c. Only a few lesions smaller than 15 mm were missed.


    572/2523

    Tytuł oryginału: The application of the Mancini technique as a diagnostic test in the CSF of tuberculous meningitis patients.
    Autorzy: Kashyap Rajpal S., Agarwal Neha P., Chandak Nitin H., Taori Girdhar M., Biswas Saibal K., Purohit Hemant J., Daginawala Hatim F.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT95-MT98, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Tuberculous meningitis (TBM) is still a serious cause of morbidity and mortality in developing nations, and the timing of treatment is the most crucial factor affecting the ultimate outcome. To establish a rapid diagnosis, we used Single Radial Immuno-Diffusion (SRID) to detect circulating mycobacterium antigen in the CSF of patients with clinically suspected TBM. Single radial immunodiffusion is the simplest of all immunotechniques for the quantitative determination of antigen or antibody. CSF was collected by standard lumbar puncture. Antiserum was raised against CSF from clinically suspected TBM patients by standard Immunization procedures. The developed protocol was tested with 73 CSF samples collected over a period of one year. The assay gave 94 p.c. sensitivity for the detection of mycobacterium antigen in the CSF of patients with clinically suspected TBM. This study suggests that single radial immunodiffusion is useful for quantitative as well as qualitative determination of mycobacterium antigen. The developed technique is of potential value in the laboratory diagnosis of TBM.


    573/2523

    Tytuł oryginału: Efficiency of CT-angiography in the diagnosis of intracranial aneurysms.
    Autorzy: Sąsiadek Marek, Kowalewski Krzysztof, Turek Tomasz, Hendrich Barbara, Podkowa Jacek, Maksymowicz Hanna
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT99-MT109, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: CT-angiography is a non-invasive method, alternative to cerebral angiography in the diagnosis of intracranial aneurysms. The aim of the study was the assessment of the efficiency of CT-angiography in a large material, which has been mostly verified with angiography ad/or surgery. CT-angiography was performed in 196 patients with intracranial bleeding. Seventy-three (73) patients underwent also cerebral angiography (CA), 121 were operated on, 74 of them solely on the basis of CT-angiography. A spiral CT scanning (2 mm slices, 1-1.5 pitch, 1 mm-gap reconstruction) combined with an injection of 120 mL of contrast medium (5 mL/sec) was used. Subsequently three-dimensional MIP reconstructions were received, supplemented in some cases with SSD, VRT and MPR. CT-angiography revealed 128 aneurysms in 106 patients, located mostly in anterior communicating, middle cerebral and internal carotid arteries. The size of most aneurysms was 6 - 10 mm, but nearly one-third of them did not exceed 5 mm. In the group of patients who underwent CA, there was only 1 false negative CT-angiography result, while in 7 patients CT- angiography allowed for the diagnosis of small aneurysms which were not clearly visible on CA. CT-anioggraphy was superior to CA in assessment of aneurysm morphology by 3 independent radiologists in 17 out of 22 cases. CT-angiography findings were confirmed during surgery in all 74 patients. CT-angiography is highly effective in the diagnosis of intracranial aneurysms and the evaluation of their morphology. In our opinion, in most cases, CT-angiography is precise enough to plan a surgical or endovascular procedure.


    574/2523

    Tytuł oryginału: MR in neurological syndromes of connective tissue diseases.
    Autorzy: Walecki Jerzy, Sierakowski Stanisław, Lewszuk Andrzej, Sulik Agnieszka, Tarasów Eugeniusz, Łebkowska Urszula
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT105-MT111, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Neurological complications in the course of SLE are mostly associated with vascular chagnes. An important role in their pathogenesis is played by immune mechanisms. The aim of the study was to determine the value of modern imging techniques, with special refrence to selected MR sequences (FLAIR, DWI) in the diagnosis of cerebral changes in patients with neurological symptoms of SLE. Fifty patients with neurological symptoms of SLE underwent CT and MR of CNS in routine sequences. In 12 cases EPI DWI sequences were also performed. Serum levels of antinuclear, anti-native DNA and antiphospholipid antibodies were also determined. The changes in CNS were detected in 48 patients in MR and in 42 patients in CT. Focal changes were observed in 29 cases, while atrophic chagnes were seen in the majority of subjects. In 10 cases, DWI showed changes typical for acute stroke. The extend and advancement of changes in CT and MR correlated with the severity of neurological symptoms; there was also a correlation between the changes and elevated levels of antiphosphlipid antibodies. FLAIR was useful in the detection of gliosis and cortical scar, while DWI enabled us to detect acute ischaemic foci and to distinguish them from coexistent scars. MRI with FLAIR and DWI sequences enhances the sensivity and specifity of neuroimaging techniques in the diagnosis of neropsychiatric disease in SLE. There is a correlation between elevated titre of antiphospholipid antibodies and the presence of vascular changes in patients with neurological manifestations of SLE.


    575/2523

    Tytuł oryginału: Stress-related diseases - a potential role for nitric oxide.
    Autorzy: Esch Tobias, Stefano George B., Fricchione Gregory L., Benson Herbert
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA103-RA118, tab., bibliogr. 195 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Nitric oxide (NO) is involved in stress physiology and stress-related disease processes. Like stress, NO seems to be capable of principally exerting either beneficial or deleterious effects. The actual distinction depends on a multitude of factors. Moreover, NO conteracts norepinephrine (NE) activity and sympathetic responsivity. Thus, NO and the stress (patho)physiology are closely connected ad molecular mechanisms or pathways may be shared under certain conditions. NO is involved in immunological, cardiovascular, and neurodegenerative diseases/mental disorders. It represents a 'double-edged sword', since small quantities produced by constitutive enzymes may predominantly mediate physiological effects, whereas the expression of inducible NO synthases may lead to larger quantities of NO, a situation that may be associated with cytotoxic and detrimental effect of NO. The key step for normally useful physiological mechanisms beacoming pathophysiological may be represented by the loss of balance, the loss of control over the different pathways induced. A failure to terminate or shift originally protective mechanisms may lead to a vicious cycle of disease-supporting pathophysiological pathways. Profound connections between stress and various disease processe exist. Thereby, common pathophysiological pathways in stress-related diseases have been described, ant they involve stress hormone (cortisol, NE) and, in particular, NO activity. Thus, NO has detrimental capacities. However, NO not only exerts deleterious but also strongly ameliorating effects. The balance between both properties is crucial. Yet, nitric oxide involvement in stress-related disease represents a common pathway, with various pathophysiogical analogies, that may be accessible for strategies using stress mangement and relaxation response techniques.


    576/2523

    Tytuł oryginału: Hydrolysis of cortex peptidoglycan during bacterial spore germination.
    Autorzy: Makino Shio, Moriyama Ryuichi
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA119-RA127, il., tab., bibliogr. 58 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Despite the most extreme dormancy and resistance properties among living systems, bacterial endospores retain an alert sensory mechanism to respond to the germinants and initiate germination. Although the molecular mechanism of the germiantion process is not completely described, current progress in the studies on the enzymes involved in the process gave us a some what clearer picture of the process of spore peptidoglycan (cortex) hydrolysis, a major biochemical event in germination. Germiantion-specific cortex-lytic enzymes require muramic acid ë-lactam in their substrates. At least two types of enzymes are involved in the germination process: a spore cortex-lyticenzyme (SCLE) and a cortical fragment-lytic enzyme (CFLE). Except for their peptidoglycan-binding regions, the primary structures of SCLE and CFLE vary according species. Both enzymes differ in their hydrolytic bond-specificities and recognition of the substrates morphology. SCLE appears to initiat germination by uncrosslinking the intract cortex, and the CFLE further degrades the polysaccharide moiety of the SCLE-modified cortex. In vivo CFLE activity is likely regulated by its requirement for partially uncrosslinked cortex, while SCLE requires activation process. Clostridium perfringens SCLE is activated by a germination-specific serine protease during germination, but the activation mechanism of SCLE in Bacillus species is unknown. Cortex-lytic enzymes are expressed at the early stage of sporulation but the compartment of expression depends on proteins. However, all enzymes are located outside the cortex layer in dormant spores, suggesting that the hydrolysis process initiates at the exterior side of the cortex. The assembly of the germination apparatus is also discussed.


    577/2523

    Tytuł oryginału: Wireless capsule endoscopy - beyond the frontiers of flexible gastrointestinal endoscopy.
    Autorzy: Rabenstein Thomas, Krauss Norbert, Hahn Eckhart G., Konturek Peter
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA128-RA132, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • psy

    Streszczenie angielskie: Wireless capsule endoscopy is currently the outstanding technical innovation in diagnostic gastrointestinal endoscopy. Especially for small bowel diseases this new technique offers several potential advantages compared to traditional diagnostic tools. Capsule endoscopy is a painless procedure that can be performed as an ambulatory endoscopic examination. First experimental studies proved the good tolerance of the capsule endoscopy ad the possibility of a complete visual investigation of the small bowel. Clinical studies demonstrated possible fields of application: Obscure chronic or intermittent gastrointestinal blood loss and inflammatory bowel disease. The major risk of the procedure - intestinal obstruction by the capsule - may hinder its use in the diagnosis of polyps or tumors in the small bowel. In the next years it will be exciting to see whether capsule endoscopy will finally reach the clinical significance we expect at the moment. Possibly, the diagnostic algorithm for obscure gastrointestinal bleeding has to be changed in the future due to the abandonment of less effective procedures.


    578/2523

    Tytuł oryginału: Ultrastructural observations of intermediate cells in chronic pancreatitis.
    Autorzy: Szynaka Beata, Zimnoch Lech, Puchalski Zbigniew
    Źródło: Hepatogastroenterology 2002: 49 (46) s.1120-1123, il., bibliogr. 28 poz.
    Sygnatura GBL: 304,355

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background/Aims: The intermediate cells exibiting both exo- and endocrine features occur in small numbers in the normal and pathologic pancreas of many animal species. In human pathology their presence has ben reported in children with hyperinsulinemia, in hypoglycemia, and chronic hypergastrinemia. Methodology: Fragments of the pancreas collected from 27 patients operated on for chronic pancreatitis of various intensity fibrosis (1ř - IVř) was subjected to ultrastructural analysis. Results: All chronic pancreatitis cases revealed the presence of intermediate cells that were found outside Langerhans islets, separately or in small groups. They were more common in IIIř and IVř chronic pancreatitis. All forms of chronic pancreatitis with Iř - IVř fibrosis showed, apart from undamage cells, numerous intermediate cells with features of destruction. Some intermediate cells contained fibrilate cytoplasm inclusion bodies. Intermediate cells took part in the formation of acini and were also found among ductural cells. Conclusions: The presence of intermediate cells both within the acinar texture and among proliferating ductular cells conforms the common origin of these cellular elements of the pancreas. In chronic pancreatitis intermediate cells appear during pancreatic texture regeneration, being rather abnormal cell forms produced in this process than an intermediate stage in precursor cell diferentiation.


    579/2523

    Tytuł oryginału: Mast cells and pancreatic stellate cells in chronic pancreatitis with differently intensified fibrosis.
    Autorzy: Zimnoch Lech, Szynaka Beata, Puchalski Zbigniew
    Źródło: Hepatogastroenterology 2002: 49 (46) s.1135-1138, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 304,355

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background/Aims: The pathogenesis of pancreatic fibrosis is unknown. Pathogenic analyses take into account the effect of oxidant stress and the increase in free radicals leading to degranulation of mast cells, which may cause inflammation and activate fibrosis. Activated pancreatic stellate cells produce abnormal components of intercellular substance and are responsible for pancreatic fibrogenesis. The aim of the study was to determine the correlation between the presence and state of mast cells and pancreatic stellate cells activation in chronic pancreatitis with varied intensity fibrosis. Methodology: We studied 27 patients with chronic pancreatitis of varied fibrosis intensity. Immunohistochemical reactions for mast cells (anti-human mast cell tryptase) and ultrastructural analyses of mast cells and pancreatic stellate cells were performed. The number of degranulated mast in the ultrastructural picture and the number of pancreatic stellate cells stained positive for vimentin and ŕ-smooth muscle actin were counted. Results: A significant increase was revealed in the number of degranulated mast cells - to 35.6 p.c. in chronic pancreatitis Iř fibrosis, 68.3 p.c. in IIř, 75.1 p.c. in IIIř and IVř (control 10.2 p.c.) and a parallel increase in the number of activated pancreatic stellate cells (stained positive for ŕ-smooth muscle actin) to 328 ń 29/mmý in Iř fibrosis, to 978 ń 67/mmý in IIř and 2355 ń 331/mmý in IIIř and IVř (control 38.8 ń 9/mmý). Conclusions: The increase in the number of activated pancreatic stellate cells parallel to the increase in degranulated...


    580/2523

    Tytuł oryginału: Plasmin/alpha2-antiplasmin complexes (PAP) in lung cancer patients: effects of radiotherapy.
    Autorzy: Uszyński Mieczysław, Ziółkowska Ewa, Żekanowska Ewa, Uszyński Waldemar
    Źródło: Thromb. Haemost. 2002: 88 (1) s.169-170, il., bibliogr. 2 poz.
    Sygnatura GBL: 304,333

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • list i notatka
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    581/2523

    Tytuł oryginału: The inhibitory effect of the fungicides captan and captafol on eukaryotic topoisomerases in vitro and lack of recombinagenic activity in the wing spot test of Drosophila melanogaster.
    Autorzy: Rahden-Staroń Iwonna
    Źródło: Mutat. Res 2002: 518 (1/2) s.205-213, il., tab., bibliogr. 53 poz.
    Sygnatura GBL: 304,952

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • in vitro

    Streszczenie angielskie: In studies on the mechanisms of mutagenic and carcinogenic action of captan and captafol-related chloroalkylthiocarboximide fungicides, two effects were tested: (i) the effect of both compounds on the activity of eukaryotic topoisomerase I and II in vitro, and (ii) their mutagenic and recombinagenic activity in the somatic mutation and recombination test (SMART) in wing cells of Drosophila melanogaster. Only captofal inhibited the activity of topoisomerase I (10-20 p.c. inhibition of activity in the range of 10-100 ćM). In contrast, both chemical decreased the activity of topoisomerase II already at 1 ćM concentration (50 and 20 p.c. inhibition of activity by captafol and captan, respectively). Genotoxicity was tested in vivo by administrating both compounds by acute (3 h) and chronic feeding (48 h) of 3-day-old exposure concentration range. Both chemical were inconclusive for large single spots, as well as for twin spots. In chronic treatment, captan showed positive results only for small single and total spots at 2.5 and 5 mM concentrations. Captafol gave inconclusive results over all concentrations tested. The results of the acute treatment experiments which have been performed at very high doses (50 p.c. toxicity at higher doses) indicate very weak overall mutagenic activity of both test fungicides.


    582/2523

    Tytuł oryginału: Urinary tract infections caused by endemic multi-resistant Enterobacter cloacae in a dialysis and transplantation unit.
    Autorzy: Kamińska W., Patzer J., Dzierżanowska D.
    Źródło: J. Hosp. Infect. 2002: 51 (3) s.215-220, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 306,296

    Hasła klasyfikacyjne GBL:
  • pediatria
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: In the period 1994-1998, 42 multi-resistant Eneterobacter cloacae isolates responsible for urinary tract infections (UTIs) were obtained from children hospitalized in our dialysis and transplantation unit. E. cloacae isolates obtained between 1994 and 1996 were susceptible to aminoglycosides, carbapenems and fluoroquinolones, whereas E. cloacae isolates obtained between 1997 and 1998 were susceptible to carbapenems and fluoroquinolones, only. All isolates were characterized by use of the polymerase chain reaction-based random amplification of polymorphic DNA and pulsed-field gel electrophoresis. It was found that the majority of multiresistant E. cloacae isolates obtained during 1997-1998, and all isolates obtained during 1994-1996, belonged to predominant clones A or B. These strains were responsible for gastrointestinal tract colonization and UTI of renal transplant recipients for several years, and persisted as endemic E. cloacae strains in the dialysis and transplantation unit from 1994 to 1998.


    583/2523

    Tytuł oryginału: The relationship between gastric cancer cells circulating in the blood and microsatellite instability positive gastric carcinomas.
    Autorzy: Czopek J., Bialas M., Rudzki Z., Zazula M., Pituch-Noworolska A., Zembala M., Popiela T., Kulig J., Kołodziejczyk P., Stachura J.
    Źródło: Aliment. Pharmacol. Ther. 2002: 16 suppl. 2 s.128-136, il., tab., bibliogr. 31 poz. - 9 Międzynarodowe Sympozjum nt. gastroenterologii Shimoda 26-27.04. 2001
    Sygnatura GBL: 306,346

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacground: Cancers characterized by microsatellite instability may be biologically different from their counterparts with stable microsatellite sequences. Circulating cancers cell present in blood prior to surgery may constitute an adverse prognostic finding. Aim: To correlate these two phenomena with morphological features and survival in advanced gastric cancer. Methods: We examined 76 cases of resected sporadic, advanced gastric cancer by means of routine morphology and a panel of microsatellite markers. Sixty-six cases were screened for presence of cancer cells circulating in blood prior to the surgery using combined morphological and immunocytochemical approach. Results: Twenry-one (27.6 p.c.) cases demonstrated microsatellite instability in at least one locus. Among them 11 (14.5 p.c. showed microsatellite instability in more than 30 p.c. (4/12) examined loci, and they were therefore designated as replication error positive (RER+). Circulating cancer cells were detected in 2/19 microsatellite instability and in 11/47 remaining cases (difference not significant). The survival of the microsatellite instability cases was significantly better. The presence of circulating cancer cells did not correlate with survival. Conclusion: It is possible that the microsatellite instability status, but not circulating cancer cells, constitutes a prognostic predictive factor in advanced gastric carcinoma. Confirmation of this hypothesis requires continuation of patient follow-up.


    584/2523

    Tytuł oryginału: Enrichment of normal progenitors in counter-flow centrifugal elutriation (CCE) fractions of fresh chronic myeloid leukemia leukapheresis products.
    Autorzy: Dłubek Dorota, Dybko Jarosław, Wysoczańska Barbara, Laba Anna, Klimczak Aleksandra, Kryczek Ilona, Konopka Lech, Lange Andrzej
    Źródło: Eur. J. Haematol. 2002: 68 (5) s.281-288, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 304,912

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Objectives: The aim of this study was to assess the suitability of a technique based on counter-flow centrifugal elutriation (CCE), which should allow one to enrich chronic myeloid leukemia (CML) patients' unstimalated native leukapheresis product (nLP) in CD34+ HLADR cells and BCR-ABL negative cells. Methods: Six newly diagnosed CML patients were subjected to leukapheresis, and the products were subfractionated with the use of CCE. nLP and all fractions were studied for the presence of CD34+ cells and a proportion of BCR-ABL fluorescence in situ hybridization (FISH)+ cells. Results: CCE fractions with a high flow rate contained the highest proportion of CD34+ cells [mean (SEM) 6.89 p.c. (3.88)]. However, CD34+ cells present in low-rate CCE fractions showed a higher proportion of HLADR- [49.6 p.c. (13.5 in 70 mL min -1) and 21.5 p.c. (11.6 in 110 mL min-1)] than those in 170 mL min-1 [3.2 p.c.(2.5)] and 'rotor off'[3.4 p.c. (1.9)]. This was associated with lower proportions of BCR-ABL FISH+ [8.1 p.c. (4.8) and 1.9 (1.7)] and smaller BCR-ABL to ABL transcript ratios [0.58 (17) and 0.26 (0.08) in 70 and 110 mL min-1] fractions as compared to 140 and 170 mL min-1 fractions [21.6 p.c. (5.2) and 31.6 p.c. (15.3) for BCR-ABL FISH+ cells and 0.75 (0.16) and 0.90 (0.24) for BCR-ABL/ABL]. Fractions with the lowest proportions of BCR-ABL-positive cells and the lowest BCR-ABL/ABL transcript ratios (110 mL min-1) contained from 1.3 x 10**6 to 82.7 x 10**6 (median: 3.97 x 10**6) CD34+ cells. Conclusions: In the present study we have shown that CCE may be used effectively to obtain nLP fractions enriched in normal hematopoietic progrenitors.


    585/2523

    Tytuł oryginału: Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets.
    Autorzy: Majka Marcin, Ratajczak Janina, Villaire Gaston, Kubiczek Krystyna, Marquez Leah A., Janowska-Wieczorek Anna, Ratajczak Mariusz Z.
    Źródło: Exp. Hematol. 2002: 30 (7) s.751-760, il., tab., bibliogr. 51 poz.
    Sygnatura GBL: 305,749

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: The development of megakaryocytes is regulated by thrombopoietin (TPO), which binds to the c-mpl receptor, and by several other cytokines such as interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), cilliary neurotropic factor (CNTF), and oncostatin (OSM), which bind to gp130 protein-coupled receptors. We attempted to identify signal transduction pathways activated by these factors in normal human megakaryocytes. Materials and methods: To better understand the role of these factors in normal human megakaryopoiesis we studied their effect on 1) purified human bone marrow-derived CD34+ cells, 2) human ŕIIbá3+ cells (shown by immunophenotypical and morphological criteria to be megakaryoblasts), which had been expanded ex vivo from CD34+ cells in chemically defined artificial serum, and 3) gel-filtered human peripheral blood platelets. Further, in an attempt to correlate the influence of these factors on cell proliferation and survival activation of signal transduction pathways, we evaluated their effect on the phosphorylation of MAPK p42/44 and activation of PI-3K-AKT and JAK-STAT proteins in these various cell types. Results: Using serum-free liquid cultures, we found that only TPO and IL-6 protected CD34+ cells and megakaryocytes from undergoing apoptosis (decrease in annexin-V binding, PARP cleavage, and activation of caspase-3). Moreover, only TPO when used alone and IL-6 only when used in combination with TPO, stimulated the growth of human colony-forming unitmegakarocytes (CFU-Meg) in semisolid serum-free medium...


    586/2523

    Tytuł oryginału: Synthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cells.
    Autorzy: Bielawski Krzysztof, Bielawska Anna, Wołczyński Sławomir
    Źródło: Biol. Pharm. Bull. 2002: 25 (7) s.916-919, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,043

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: A series of carbamate derivatives of Hoechst 33258 was prepared as potential anticancer agents. These new compounds (1-4) were readily prepared in good yields by addition of chloroethyl, bromoethyl, chloropropyl or 4-(chloromethyl)phenyl isocyanates to Hoechst 33258. Their cytotoxic activity was evaluated on human breast cancer MCF-7. Compounds 1-4 were more cytotoxic than Hoechst 33258. In particular derivatives 4, the most active of the series, is up to 3 times more potent than Hoechst 33258. The DNA-binding ability of these compounds was evaluated by an ultrafiltration method using calf thymus DNA. These data show that in broad terms the cytotoxic potency of 1-4 in cultured breast cancer MCF-7 cells incerases, in accord with their increases in DNA affinity, as shown by the binding constant values.


    587/2523

    Tytuł oryginału: The effect of ascorbic acid and ethanol on the level of thiobarbituric acid reactive substances (TBARS) in selected tissues of albino BALB/c mice.
    Autorzy: Woźniak Alina, Woźniak Bartosz, Drewa Gerard, Kasprzak Heliodor Adam
    Źródło: Biol. Pharm. Bull. 2002: 25 (7) s.943-944, tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,043

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The aim of the paper was to study the effect of ascorbic acid (vitamin C) and ethanol on the level of thiobarbituric acid reactive substances (TBARS) in the brain, lungs and blood serum of inbred albino BALB/c mice. Sixty male mice divided into 4 groups were used for the study; the mice in each group were injected intraperitoneally (.p.): Group 1 - control, saline; Group 2 - H202 and FeSO4; Group 3 - ascorbic acid (AA); Group 4 - AA and ethanol. The level of TBARS in the investigated tissues of the mice in all of the groups was statistically significant higher than than in the control group. The highest content of TBARS in blood serum, brain, liver and lung tissue was observed in mice which were given ascorbic acid and ethanol.


    588/2523

    Tytuł oryginału: Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1.
    Autorzy: Godthelp Barbara C., Artwert Fr‚, Joenje Hans, Zdzienicka Małgorzta Z.
    Źródło: Oncogene 2002: 21 (32) s.5002-5005, il., tab., bibliogr. [29] poz.
    Sygnatura GBL: 312,857

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Fanconi anemia is a hereditary cancer susceptibility disorder chracterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents such as mitomycin C. This phenotype suggests a possible role for the Fanconi anemia proteins in the repair of DNA lesions induced by these agents, but the molecular mechanism underlying the defect in this disorder has not yet been identified. Here, we show that amongst eight so far identified complementation groups of Fanconi anemia, only fibroblasts derived from group D1 are defective in the formation of nuclear Rad51 foci after X-ray irradiation or mitomycin C treatment. This indicates that the FANCD1 gene product is uniquely involved in the assembly and/or stabilization of the Rad51 complex. Since DNA dmage-induced Rad51 nuclear foci are thought to reflect of DNA double-strand breaks by homologous recombination, our results suggest that FANCD1 is likely to be involved in homologous recombination-dependent repair.


    589/2523

    Tytuł oryginału: Endothelium-dependent production and liberation of kynurenic acid by rat aortic rings exposed to L-kynurenine.
    Autorzy: Stążka Janusz, Luchowski Piotr, Wielosz Marian, Kleinrok Zdzisław, Urbańska Ewa M.
    Źródło: Eur. J. Pharmacol. 2002: 448 (2/3) s.133-137, il., bibliogr. [19] poz.
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Rat aortic slices produced and liberated the endogenous antagonist of glutamate receptors, kynurenic acid, upon exposure to L-kynurenine. Endothelium-denuded slices did not synthesize any measurable amount of kynurenic acid, indicating its endothelial origin. Aortic kynurenic acid production was diminished by modification of the ionic milieu, hypoxia and hypoglycemia, as well as by L-glutamate and L-aspartate, endogenous glutamate receptor agonists, and aminooxyacetic acid, a non-selective inhibitor of aminotransferase and mitochondrial respiration. These data pave the way for future research aimed to clarify to the role of kynurenic acid in the physiology and pathology of the endothelium and vasculature.


    590/2523

    Tytuł oryginału: Effect of imipramine on brain D-1 and 5-HT-2A receptors in a chronic unpredictable stress model in rats.
    Autorzy: Ossowska Grażyna, Nowak Gabriel, Klenk-Majewska Bożena, Danilczuk Zofia, Żebrowska-Łupina Iwona
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.89-93, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia
  • psychiatria i psychologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Chronic unpredictable stress (CUS) model of depression is one od the well validated animal models of depression. In this paper, we report the results of investigations into dopaminergic D-1 and serotonergic 5-HT-2A receptors in the brain of rats subjected to CUS procedure and treated chronically with imipramine. We have examined the dopaminergic D-1 ([3H-SCH 23390) in the limbic area and serotonergic 5-HT-2A ([3H-ketanserin) receptors in the cerebral cortex by a saturation radioligand binding method in rats subjected to CUS paradigm, imipramine, both CUS and imipramine and control animals. CUS procedure resulted in a significant 36 p.c. increase in the D-1 receptor density in the limbic system, which was attenuated by chronic imipramine treatment. Also a 21 p.c. increase in the density of 5-HT-2A receptors in the cerebral cortex induced by CUS was reduced by chronic imipramine treatment. The present data indicate that the increases in the density of brain D-1 and 5-HT-2A receptors of rats subjected to CUS, which are "normalized" by imipramine, might be involved in the pathophysiology of :animal depression" (and, thus, in pathophysiology of human depression) and in the mechanism of antidepressant tharapy.


    591/2523

    Tytuł oryginału: Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia.
    Autorzy: Nadlewska Agnieszka, Car Halina, Wiśniewska Róża J., Wiśniewski Konstanty
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.95-102, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The behavioral activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) a selective antagonist of metabotropic glutamate receptor subtype 5 (mGluR5), was assessed in control groups of rats and in rats that underwent short-term hypoxia. MPEP applied intravenously (iv) at the dose of 1 mg/kg was tested using the open field test, the passive avoidance test and the elevated "plus" mzae test. MPEP significantly increased the number of crossings, rearings and bar approaches in the open field test. It improved the consolidation and retrieval in the passive avoidance situation and did not produce any significant effects in control rats in the elevated "plus" maze test. Hypoxia (2 p.c. O2, 98 p.c. N2) significantly inhibited locomotor and exploratory activity of rats and also impaired consolidation and retrieval processes, but it did not evoke any changes in the elevated "plus" maze test. MPEP in hypoxia-exposed groups of rats inhibited locomotor and exploratory activity in comparison with MPEP-treated control group. Hypoxia significantly diminished beneficial effect of MPEP on consolidation. In spite of experimental conditions of hypoxia, the effect of MPEP on retrieval was preserved. MPEP used before hypoxia did not significantly influence all parameters of the elevated "plus" maze test. In conclusion, MPEP had beneficial effect on retrieval in hypoxia.


    592/2523

    Tytuł oryginału: Effects of tamoxifen, mifepristone and cyproterone on the electroconvulsive threshold and pentetrazole-induced convulsions in mice.
    Autorzy: Borowicz Kinga K., Łuszczki Jarogniew, Matuszek Mariusz, Kleinrok Zdzisław, Czuczwar Stanisław J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.103-109, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The aim of this study was to evaluate the efficacy of three antihormones, tamoxifen (TXF, an antiestrogen), mifepristone (MIF, an antiprogesterone) and cyproterone (CYP, an antiandrogen) in two major models of experimental epilepsy, electriccally and pentetrazole (PTZ)-evoked seizures in mice. TXF (20-50 mg/kg) significantly raised the threshold for electroconvulsions in female mice, whereas CYP was active in male mice. Similar effects were observed in castrated mice. Different data were obtained in sexually immature animals since both TXF and CYP exerted anticonvulsive effects in animals of both genders. MIF (5-50 mg/kg) remained without effect on electrically evoked seizures in mice. The anticonvulsive action of TXF was reversed by aminophylline, bicuculline, kainic acid and N-methyl-D-aspartic acid, but not estradiol or strychnine. The protective action of CYP was reversed by aminophylline and bicuculline, but not by testesterone, kainic acid, N-methyl-D-aspartic acid or strychnice. All three antihormones were inffective against PTZ-induced convulsions in mice. Our results suggest that the action of TXF and CYP might be indirectly associated with the respective hormonal receptor-mediated events, but the nature of this dependence is unclear and further investigations are needed to elucidate this phenomenon.


    593/2523

    Tytuł oryginału: Lack of interaction between the behavioral effects of ketamine and benzodiazepines in mice.
    Autorzy: Fidecka Sylwia, Pirogowicz Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.111-117, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The effect of co-administration of ketamine at the sub-effective dose with diazepam, chlordiazepoxide and clonazepam on their antinociceptive and protective efficacy against pentetrazole-induced seizures were studied in mice. Ketamine alone produces dose-dependent antinociception manifested as reduction in the number of writhing episodes evoked by acetic acid. In the writhing test, the antinociceptive effects of the threshold doses of diazepam, chlordiazepoxide or clonazepam were not changed by ketamine, whereas that of morphine was intensified by ketamine. In the hot plate test, slight antinonciceptive effects of the threshold dose of diazepam, but not that of chlordizepoxide (except the results at 120 min of observation), were significantly intensified by ketamine vs ketamine alone. Ketamine alone was able to protect mice, in the dose-related manner, against penetrazole-induced seizures. The anticonvulsant effects of the threshold doses of diazepam, chlordizepoxide and clonazepam were not changed by ketamine. These findings indicate that co-administration of ketamine (at the sub-effective dose) with diazepam, chlordiazepoxide and clonazepam (at non-effective) resulted in an intensification of neither antinociceptive nor protective effect against pentetrazole-induced seizures in mice. These data seem to indicate the lack of interaction between ketamine and benzodiazepines with respect to their antinociceptive and anticonvulsant efficacy.


    594/2523

    Tytuł oryginału: Adenosine receptor ligands and cocaine in conditioned place preference (CPP) test in rats.
    Autorzy: Poleszak Ewa, Malec Danuta
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.119-126, il., bibliogr. 38 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The influence of adenosine receptor agonists and antagonists on cocaine-induced conditioned place preference (CPP) was examined in male Wistar rats. Adenosine receptor agonists, when given alone, induced place preference in some dose ranges, and it seems that adenosine A1 and A2 receptors might be involved in this reaction. All adenosine receptor agonists: 2-p-(2-corboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680), A2A receptor agonist, N6-cyclopentyladenosione (CPA), A1 receptor agonist, and 5'-N-ethylcarboxamidoadenosine (NECA), A2/A1 receptor agonist did not prevent the acquisition of cocaine-induced CPP but, when administered at the lower doses, they reduced the expression of cocaine action in CPP test. Selective adenosine A1 receptor antagonist, 8-cyclopentyltheophylline (CPT), A2 receptor antagonists, 3,7-dimethyl-1-propargylxanthine, DMPX, and caffeine (non-selective A1/A2 receptor antagonist) markedly and significantly decreased the expression of CPP induced by cocaine, and caffeine (20 mg/kg) decreased also the acquisition of this reaction. Our results suggest the involvement of adenosine A1 and A2 receptors in rewarding prperties of cocaine measured in CPP test.


    595/2523

    Tytuł oryginału: Effect of subchronic ethanol treatment on plasma and cerebrospinal fluid leptin levels in rats selectively bred for high and low alcohol preference.
    Autorzy: Mikołajczak Przemysław, Okulicz-Kozaryn Irena, Kamińska Ewa, Wiktorowicz Krzysztof, Leśniewska Kinga, Dyr Wanda, Kostowski Wojciech
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.m27-132, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The effect of 5-week voluntary ethanol (EtOH) intake on plasma and cerebrospinal fluid (CSF) leptin levels was determined in adult male Warsaw high EtOH preferring (WHP) and low preferring (WLP) rats. EtOH treatment led to a decrease in leptin CSF concentration in WHP rats when compared to EtOH-naive WHP and control Wistar rats. On the contrary, in EtOH-treated WLP rats, both plasma and CSF leptin levels were increased in comparison with EtOH-naive animals. It can be concluded that EtOH treatment led to different response expressed especially by SCF leptin levels in WHP and WLP animals and it may be related to their genetic predisposition.


    596/2523

    Tytuł oryginału: Effects of porcine galanin, galanin(1-15)NH2 and its new analogues on glucose-induced insulin secretion.
    Autorzy: Ruczyński Jarosław, Cybal Magdalena, Wójcikowski Czesław, Rekowski Piotr
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.133-141, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Porcine galanin (pGAL), its 15-amino-acid-residue fragment and five new analogues modified in positions 4, 6 or 14 were tested for their effects on glucose-induced insulin secretion from isolated rat pancreatic islets of Langerhans. In vitro insulin secretion was studied during static incubation. All peptides were tested at two concentrations: 100 nM and 1 ćM. The insulin level in the presence of 10 mM of glucose was a reference for all experiments. Our studies have shown that porcine galanin and its fragment GAL(1-15)NH2 at all concentrations tested inhibit glucose-induced insulin secretion. However, the modifications of the amino acod sequence of galanin caused changes in the interaction of GAL with its receptors, consequently yielding peptides that showed reverse activity as compared to pGAL or GAL(1-15)NH2. Finally, we have found three analogues: [Cit14]GAL(1-15)-NH2, [Hse6]GAL(1-15)NH2 and [Cle4]GAL(1-15)NH2, which were able to stimulate glucose-induced insulin secretion and also antagonized inhibitory effect of pGAL. Other two galanin analogues: [D-Leu4]GAL(1-15)NH2 and [des-Leu4]GAL(1-15)NH2 showed a rather weak agonistic activity. Our observations suggest that positions: 4, 6 and 14 in the amino acid sequence of galanin may play an important role in the high-affinity binding of GAL to its receptors and biological action in perfused rat pancreas.


    597/2523

    Tytuł oryginału: Cerivastatin modulates plasma paraoxonase/arylesterase activity and oxidant-antioxidant balance in the rat.
    Autorzy: Bełtowski Jerzy, Wójcicka Grażyna, Mydlarczyk Mariusz, Jamroz Anna
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.143-150, il., bibliogr. 49 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Statins (3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors), apart from lowering plasma cholesterol, modulate other processes involved in atherogenesis. Paraoxonase (PON), contained in plasma high density lipoproteins, protects plasma lipoproteins from oxidative damage and is a potentially atheroprotective enzyme. We investigated the effect of cervastatin on oxidant-antioxidant balance and plasma PON activity. The adult male Wistar rats received cervistatin at a dose of 0.03 or 0.3 mg/kg/day for 3 weeks. Then, plasma concentration of lipid peroxidation products, total antioxidant capacity and PON activity were assayed. Plasma level of lipid peroxidation products was unchanged in low-dose group but decreased significantly in animals receiving high dose of cervivastatin. In this group, the concentration of malonyldialdehyde and 4-hydroxydialkenals was reduced by 46.6 p.c. whereas the level of lipid hydroperoxides was lowered by 59.3 p.c. Total plasma antioxidant capacity increased in low-dose group by 22.3 p.c. and in high-dose group by 27.2 p.c. PON activity toward paraoxon decreased by 16.1 p.c. and 11.6 p.c. in low- and high-dose groups, respectively. The activity toward phenyl acetate, which better corresponds wuith enzyme concentration, declined by 74.2 p.c. and 78.4 p.c. following lower and higher dose treatment, respectively. PON/arylesterase ratio raised in cervastatin-treated rats (low dose: +227.4 p.c., high dose: +328.2 p.c.).Cerivastatin had no effect on total plasma cholesterol but significantly decreased triglyceride level by 34.6 p.c...


    598/2523

    Tytuł oryginału: Influence of midazolam pharmacokinetic parameters of procainamide in rabbits.
    Autorzy: Orszulak-Michalak Daria, Owczarek Jacek, Wiktorowska-Owczarek Anna K.
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.151-155, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: The majority of antiarrhytmic drugs have very narrow therapeutic range, and they may cause some side effects at doses used for curing cardiac arrhythmias. These drugs may enter different interactions. Procainamide also may interact with other drugs. Also some other drugs may change pharmacokinetics of procainamide, for example the iv anesthetics influence on pharmacokinetic parameters of procainamide. The aim of the study was to investigate the influence of midazolam on the plasma concentrations and pharmacokinetic parameters of procainamide in rabbits during two hours of obserwation. Procainamide was administered in rabbits at a dose of 13 mg/kg iv, and midazolam at 0.2 mg/kg iv. Procainamide levels were determined by immunofluorescence polarization method using ABBOTT reagents. Levels of procainamide were determined in the plasma at 5, 10, 15, 30, 45, 60, 90 and 120 min after the administration of procainamide. After administration of midazolam with procainamide, a decrease in plasma concentration of procainamide, together with its increased elimination, was observed.


    599/2523

    Tytuł oryginału: Interactions between human platelets and eosinophils are mediated by selectin-P.
    Autorzy: Jawień Jacek, Chłopicki Stefan, Gryglewski Ryszard J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.157-160, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,156

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Mechanisms and biochemical consequences of platelet-neutrophil interactions are well known. In contrast, platelet-eosinophil interactions remain largely unexplored. The aim of this study was to assess whether platelets adhere to eosinophils, and to analyze whether selectin-P would mediate that phenomenon. Eosinophils and platelets were obtained from peripheral blood of healthy volunteers. Eosinophils were isolated using magnetic cell separation method. Platelets were isolated and washed. A number of "rosettes" (an eosinophil with more than 5 adherent platelets) per 100 eosinophils were examined in the eosinophil-platelet suspension. Addition of thrombin stimulated formation of "rosettes". Monoclonal antibodies against selectin-P almost completely prevented thrombin-stimulated formation of "rosettes". In summary, intercellular interaction between platelets and eosinophils are mediated by selectin-P. This phenomenon may be of importance in asthma and other atopic diseases.


    600/2523

    Tytuł oryginału: Saliva as an alternative specimen for alcohol determination in the human body.
    Autorzy: Gubała Wojciech, Zuba Dariusz
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.161-165, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 313,156

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Saliva, breath, and blood samples were collected from 49 volunteers and over 700 values of ethanol concentration were obtained. The profiles of time-dependent changes in saliva and expired air-breath ethanol concentration were similar. The average difference between the respective values determined in blood and saliva amounted to -0.031 ń 0.096 g/l, whereas the difference between the results for breath and saliva was -0.034 ń 0.080 g/l. These differences in ethanol concentrations do not exceed those which occur between blood and breath (0.003 ń 0.093 g/l). Introducing a correction value of 1.08, stemming from the varying water content in saliva and blood, results in a good agreement between the results for saliva and breath (0.005 ń 0.077 g/l). The headspace gas chromatgraphic method applied for ethanol determination in saliva is specific (resolution 1), shows good accuracy (recovery = 100.7 p.c.) and precision (SD = 0.0155 g/l). There is no matrix effect when water solutions are used for calibration instead of saliva.


    601/2523

    Tytuł oryginału: The Eleventh Days of Neuropsychopharmacology.
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.167-206, il., tab., bibliogr. [przy ref.] - 11 Dni Neuropsychofarmakologii Ustroń-Jaszowiec 27-29.05. 2002 - Część materiałów zamieszczono w formie streszcz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • streszczenie


    602/2523

    Tytuł oryginału: 5-HT1A receptors. Their role in anxiety and depression mechanism of activation.
    Autorzy: Chilmonczyk Zdzisław
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.175-178, il., bibliogr. 38 poz. - 11 Dni Neuropsychofarmakologii Ustroń-Jaszowiec 27-29.05. 2002
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    603/2523

    Tytuł oryginału: Serotonin and Parkinson's disease.
    Autorzy: Kostrzewa Richard M., Brus Ryszard
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.178-179 - 11 Dni Neuropsychofarmakologii Ustroń-Jaszowiec 27-29.05. 2002
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    604/2523

    Tytuł oryginału: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) as endogenous toxicants of CNS: some aspects of defense.
    Autorzy: Metodiewa Diana, Kochman Agata
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.179-181, bibliogr. 17 poz. - 11 Dni Neuropsychofarmakologii Ustroń-Jaszowiec 27-29.05. 2002
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    605/2523

    Tytuł oryginału: DT-diaphorase: a neuroprotective enzyme of dopaminergic systems.
    Autorzy: Paris I., Martinez P., Arriagada C., Dagnino-Subiabre A., Montiel J., Caviedes P., Caviedes R., Mora S., Diaz-Veliz G., Cassel B., Olea-Azar C., Aboitiz F., Segura-Aguilar J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.181-183, bibliogr. 13 poz. - 11 Dni Neuropsychofarmakologii Ustroń-Jaszowiec 27-29.05. 2002
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    606/2523

    Tytuł oryginału: Low-dose ritonavir moderately enhances nelfinavir exposure.
    Autorzy: Kurowski Michael, Kaeser Benoite, Sawyer Anthony, Popescu Matei, Mrozikiewicz Alexander
    Źródło: Clin. Pharmacol. Ther. 2002: 72 (2) s.123-132, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 311,916

    Hasła klasyfikacyjne GBL:
  • aIDS
  • farmacja
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Bacground: The protease inhibitor ritonavir is increasingly administered at subtherapeutic doses in highly acyive antiretroviral treatment, to utilize its potential for drug interactions and to enhance the plasma concentrations of other concomitantly prescribed protease inhibitors. The addition of low doses of ritonavir to nelfinvir as investigated to describe the extent of pharmacokinetic interaction. Methods: In this randomized, open-label, one-sequence crossover study, nelfinavir 1250 mg a day was dosed for 17 days, followed by 14 days of nelfinvar 1250 mg twice a day plus low doses of ritonavir of either 100 mg or 200 mg orally. Twenty-four healthy volunteers were evaluated for pharmacokinetics of nelfinavir, its metabolite M8, and ritonavir. Plasma concentrations were measured up 12 hours after moring and evening dosing, respectively, on days 14 and 31. Results: Ritonavir increased the area under the plasma concentration-time curve (AUC) of nelfinvir by 20 p.c. (P = .024) and 39 p.c. (P = .001) after moring and evening administration, respectively. The AUC of nelfinavir metabolite M8 was increased by 74 p.c. and 86 p.c. after moring and evening dosing (P .001 for both). Conclusion: During ritonavir combination therapy a clear although minor drug effect on nelfinavir pharmacokinetics was demonstrated but no dose effect was shown.


    607/2523

    Tytuł oryginału: Jan Mikulicz-Radecki (1850-1905) - the creator of modern European surgery.
    Autorzy: Gorecki Piotr, Gorecki Wojciech
    Źródło: Dig. Surg. 2002: 19 (4) s.313-318, il., bibliogr. 26 poz.
    Sygnatura GBL: 313,013

    Hasła klasyfikacyjne GBL:
  • chirurgia

    Typ dokumentu:
  • praca biograficzna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Temat osobowy:
  • Mikulicz-Radecki
  • Jan 1850-1905


    608/2523

    Tytuł oryginału: Atherosclerosis
    Tytuł angielski: Inverse relationship between total testosterone and anti-oxidized low density lipoprotein antibody levels in ageing males.
    Autorzy: Barud Wojciech, Palusiński Robert, Bełtowski Jerzy, Wójcicka Grażyna
    Źródło: Atherosclerosis 2002: 164 (2) s.283-288, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 304,815

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Accumulating evidence indicates the involvement of sex hormones in atherogenesis. Endogenous testosterone is inversely related to the majority of risk factors for atherosclerosis and is known to be a potent immunomodulator. Recently, autoantibodies to oxidized LDL (anti-oxLDL Ab) were shown to predict carotid and coronary atherosclerosis. The aim of this study was to investigate the relationship between these antibodies and testosterone level in ageing males. The study group comprised 65 males over 50 years old (42 with coronary artery disease). Serum anti-oxLDL Ab titer was measured by enzyme-linked immunoassay and total serum testosterone by radioimmunoassay. A significant inverse correlation was found between serum anti-oxLDL Ab titer and testosterone concentration (r = -0.346, P = 0.0047). Alteration in serum anti-oxLDL Ab titers showed no correlation to classical cardiovascular risk factors, e.g. body mass index, waist/hip ratio, smoking, total cholesterol, triglicerides, HDL-cholesterol, LDL-cholesterol. In multiple regression analysis only testosterone level was independently associated with anti-oxLDL Ab. These data suggest that a fall of testosterone concentration in ageing men can influence either oxidative modification of LDL or the immune response to these lipoproteins which may be important in the pathogenesis of atherosclerosis.


    609/2523

    Tytuł oryginału: Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.
    Autorzy: Wieczerzak Ewa, Drabik Piotr, Łankiewicz Leszek, Ołdziej Stanisław, Grzonka Zbigniew, Abrahamson Magnus, Grubb Anders, Br”mme Dieter
    Źródło: J. Med. Chem. 2002: 45 (19) s.4202-4211, il., tab., bibliogr. 69 poz.
    Sygnatura GBL: 312,133

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A series of azapeptides as potential inhibitors of cysteine protease were synthesized. Their structures, based on the binding center of cystatins, contain an azaglycine residue (Agly) in place of the evolutionary conserved glycine residue in the N-terminal part of the enzyme binding region of cystatins. Incorporation of Agly should lead to deactivation of the acyl-enzyme complex formed against nucleophilic attack by water molecules in the final step of peptide bond hydrolysis. The majority of synthesized azapeptides shows high inhibitory potency toward the investigated cysteine proteases, papain, cathepsin B, and cathepsin K. One of them, Z-Arg-Leu-Val-Agly-Ile-Val-OMe (compound 17), which contains in its sequence the amino acid residues from the N-terminal binding segment as well as the hydrophobic residues from the first binding loop of human cystain C, proved to be a highly potent an selective inhibitor of cathepsin B. It inhibits cathepsin B with a Ki value of 0.088 nM. To investigate the influence of the structure of compound 17 for its inhibitory properties, we determined its conformation by means of NMR studies and theoretical calculations. The Z-Arg-Leu-Val-Agly fragment covalenty linked to Cys29 of cathepsin B, was also developed and modeled, in the catalytic pocket of the enzyme, through a molecular dynamics approach, to analyze ligand - protein interactions in detail. Analysis of the simulation trajectories generated using the AMBER force field provided us with atomic-level understanding of the conformational variability of this inhibitor, which is discussed in the context of other experimental and theoretical data.


    610/2523

    Tytuł oryginału: Global motion detection is impaired in cats deprived early of pattern vision.
    Autorzy: Burnat Kalina, Vandenbussche Erik, Żernicki Bogusław
    Źródło: Behav. Brain Res. 2002: 134 (1/2) s.59-65, il., bibliogr. 45 poz.
    Sygnatura GBL: 312,662

    Hasła klasyfikacyjne GBL:
  • neurologia
  • okulistyka

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • koty

    Streszczenie angielskie: We investigated global motion detection in binocularly deprived cats (BD cats) and control cats (C cats). The cats were trained in the two-choice free running apparatus for a food reward. The positive stimulus was a moving random-dot pattern with all dots moving in one direction, the negative stimulus was the same random-dot pattern but stationary. The BD cars were severly impaired in detection of global motion stimulus as compared with the C cats. In contrast, their level of performance in a simple relative motion detection task (one square) did not differ from that in the C cats. However, in more complex relative motion detection task (two squares) the performance of the BD cats was impaired. The deficit in the detection of global motion in BD cats may be due to impairments of their Y-pathway.


    611/2523

    Tytuł oryginału: Septal vasopressin induced preservation of social recognition in rats was abolished by pinealectomy.
    Autorzy: Appenrodt Edgar, Juszczak Marlena, Schwarzberg Helmut
    Źródło: Behav. Brain Res. 2002: 134 (1/2) s.67-73, il., tab., bibliogr. 47 poz.
    Sygnatura GBL: 312,662

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The role of intraseptal vasopressin (AVP) and the pineal gland in the modulation of social memory was investigated. For social recognition, male pinealectomised (Px) and sham-operated (SO) rats were confronted with juveniles for 4 min, and injected with either 200 pg AVP or 5 ng of its V1 receptor antagonist d(CH2)5Tyr(Me)AVP(AAVP) into the mediolateral septum. Re-exposure to the same and a different juvenile took place after 30 or 120 min. In SO rats, the social memory was facilitated after injection of AVP (120 min) and impaired after AAV application (30 min). In Px rats, however, neither AVP nor AAVP administration influenced the social memory. Comparison between SO and Px control groups treated with artificial cerebrospinal fluid did not reveal any differences as to social recognition responses. After subcutaneous administration of 250 ćg melatonin (substitution for pinealectomy) the social discrimination responses in Px rats after peptide application were influenced in a manner identical to that noted in SO animals. These finding suggest that the modulation of social memory by intraseptal AVP is dependent on an intact pineal function.


    612/2523

    Tytuł oryginału: Comparison of Multiplex PCR, and an immunochromatographic method sensitivity for the detection of Escherichia coli O157:H7 in minced beef.
    Autorzy: Gryko Romuald, Sobieszczańska Beata M., Stopa Peter J., Bartoszcze Michał A.
    Źródło: Acta Microbiol. Pol. 2002: 51 (2) s.121-129, il., tab., bibliogr. [30] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In this study, the sensitivities of multiplex PCR and an immuno-chromatographic methods to detect Escherichia coli 0157:H7 in minced beef were compared. The detection of Escherichia coli 0157:H7 in minced beef inoculated with 1-100 cells of this bacterium was possible after enrichment of culture and subsequent analysis by either of two methods. Enrichment conditions were eight hours of incubation at 37řC or 42řC in a non-selective medium (Buffered Peptone Water). Multiplex PCR analysis was performed using three primer sets with analysis by gel electrophoresis. The QuixTM immuno-chromatographic assay which is a new kit being marketed by New Horizons Diagnostics, Columbia, MD, was used for immunological analysis of the enriched broths. The sensitivity of both tests was similar. The results depended on the concentration of the specific bacterium in the culture since the influence of the proportion of other bacteria to the E. coli 0157:H7 was not observed. The data suggests taht either method or used together, when coupled with an enrichment technique, could provide a rapid mean to detect the presence of this pathogen in minced meat samples.


    613/2523

    Tytuł oryginału: Protein Z in young survivors of ischemic stroke.
    Autorzy: Łopaciuk Stanisław, Bykowska Ksenia, Kwieciński Hubert, Członkowska Anna, Kuczyńska-Zardzewiały Arletta
    Źródło: Thromb. Haemost. 2002: 88 (3) s.536, il., bibliogr. 5 poz.
    Sygnatura GBL: 304,333

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • list i notatka
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    614/2523

    Tytuł oryginału: Health and social problems of addicted persons on methadone treatment program.
    Tytuł polski: Problemy zdrowotne i społeczne osób uzależnionych objętych programem metadonowym.
    Autorzy: Karakiewicz Beata, Kozielec Tadeusz, Durska Grażna, Stanaszek Roman
    Źródło: Pol. Med. Rodz. 2002: 4 (3) s.365-369, il., tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 313,549

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: W pracy przeanalizowano wybrane problemy zdrowotne i społeczne u osób uzależnionych od substancji psychoaktywnych. Badaniem objęto 70 osób - pacjentów oddziału detoksykacyjnego oraz programu metadonowego SPS ZOZ-u Psychiatrycznego "Zdroje" w Szczecinie. Z przeprowadzonych badń wynika, że mężczyźni częściej uzależniają się od substancji psychoaktywnych niż kobiety. Osoby uzależnione od narkotyków mają niski poziom wykształcenia i często są bezrobotne (bez prawa do zasiłku). U większości badanych osób w przebiegu uzależnienia wystąpiły dodatkowe problemy zdrowotne. Terapia substytucyjna programu metadonowego osób uzależnionych od opiatów w sposób znaczący wpływa na redukcję szkód zdrowotnych i społecznych narkomanii.

    Streszczenie angielskie: The paper contains analysis of chosen social and health problems in psychoactive substance abusers in Szczecin, Poland. Seventy psychoactive substance dependent individuals were enrolled into the study (patients from the Detoxification Ward and patients participating in methadone program). The results of the study showed higher uncidence of psychoactive substance abuse in males than in females. Low educational level and unemployment were found in the studied population. Drug dependent individuals frequently had criminal record. The following additional health problems were found in psychoactive substance abusers: epilepsy, inflammatory skin disease, central nervous system injuries, HIV and hepatotropic viruses cerrier state. Methadone program allows reduction of health and social harms in opiate dependent patients.


    615/2523

    Tytuł oryginału: Activity of neuraminidase on the structure of rabbit kidney glomerular basement membranes; spin label study.
    Tytuł polski: Ocena wpływu neuraminidazy na strukturę błony podstawnej kłębuszków nerkowych w modelu eksperymentalnym u królików za pomocą techniki rezonansu spinowego.
    Autorzy: Sapilak Bartosz J., Steciwko Andrzej, Olsztyńska Sylwia, Komorowska Małgorzata
    Źródło: Pol. Med. Rodz. 2002: 4 (3) s.371-375, il., bibliogr. 23 poz., streszcz.
    Sygnatura GBL: 313,549

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie polskie: Cel badania: Jakkolwiek relatywnie dobrze poznano etiologię i patogenezę kłębuszkowego zapalenia nerek (k.z.n.), to nadal nie możemy poznać zachodzących w mikrostrukturze bariery filtracyjnej kłębuszków prowadzących do utraty selektywności filtracji i powstawania proteinurii. Dotychczas stowane techniki badawcze okazały się mało przydatne. W naszych badaniach podjęliśmy próbę zaadaptowania nowej techniki elektronowego rezonansu spinowego (ERS), by uzyskać istotne informacje o patomechanizmie k.z.n. Materiał i metody: Do badań użyliśmy królików obojga płci dobranych pod kątem dobrej kondycji zdrowotnej i wieku (1,5-2 lata). Zwierzętom podawaliśmy dożylnie przez kolejne 3 dni aktywną enzymatycznie neuraminidazę, zgodnie ze schematem wypracowanym w naszym laboratorium. Dla celów doświadczenia utworzono jedną grupę kontrolną i pięć grup badanych, różniących się dawką podawanej neuraminidazy. Po skrwawieniu zwierząt pobrano obie nerki, wypreparowano ich korę, z której na drodze obróbki mechanicznej uzyskano najpierw kłębuszki nerkowe, a następnie na drodze wielokrotnej ultrasonifikacji wolną od zanieczyszczeń tkankowych zawiesinę błon podstawnych kłębuszków nerkowych (BP). Roztwór BP znakowano jednym z dwóch znaczników spinowych: MSL (3-maleimido-1-oxyl-2,2,5,5,-tetramethylpyrrolidiny) lub JAA (jodoacetamid-1-oxyl-2,2,5,5,-tetramethylpyrrolidiny). Uzyskane widma otrzymano badając tak przygotowany materiał na spektrometrze Se/X-28. By ocenić ruchliwość znaczników spinowych podczas ich izotropowej rotacji w polu elektromagnetycznym, wyznaczano czas korelacji...

    Streszczenie angielskie: Purpose of studies: an estimation of structural and three-dimensional changes in organization of kidney glomerular basement membrane components appearing in experimentally caused glomerulonephritis. We have used 1,5 - 2 years old rabbits. They were divided into a few groups, with different amount of intravenous injected active neuraminidase, and also separate control group. Glomerular basemet membranes from collected animals kidneys according to method developed by Spiro were prepared. Then obtained preparates were labelled by 3-maleimido-1-oxyl-2,2,5,5,-tetramethylpyrrolidine (MSL) and 4-(iodoacetamido)-1-oxyl-2,2,5,5,-tetramethylpyrrolidine (JAA) sulfhydryl specific spin labels. Measured ESR spectra of labelled membranes show significant changes of spin labels mobility and this effect dependents on neuraminidase concentration. In comparison with intact membranes neuraminidase action on membranes creates three different ESR signals what is connected with different protein fractions. The changes in structure of basement membranes caused by nauraminidase correspond with increasing glomellural wall permability.


    616/2523

    Tytuł oryginału: Fibrous-long spacing collagen in post-partum rat cervix uteri.
    Autorzy: Mackiewicz Zygmunt, Stepaniuk Mirosława, Mackevicius Zigmuntas jr
    Źródło: Acta Med. Lituan. 2002: 9 (2) s.126-129, il., bibliogr. 20 poz., santr.
    Sygnatura GBL: 313,255

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Fibrous-long spacings (FLS) are one of atypical or artificial forms of collagen fibrils. We analyzed occurrence of this form of interstitial collagens of cervix uteri in pregnant, nonpregnant and post-partum white Wistar rats. Light and electron microscopy were used. Extensive collagenolysis in rat cervical stroma on the eve of labour and in close post-partum period was found. Extravasated activated eosinophils participated in this process. In the solid milieu of massive collagenolysis FLS were found. FLS were not found in nonpregnant cervix ureri. Administration of bleomycin had no influence on collagen degradation rate or on FLS formation.


    617/2523

    Tytuł oryginału: Synthesis, antiarrhythmic, and antihypertensive effect of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity.
    Autorzy: Malawska Barbara, Kulig Katarzyna, Filipek Barbara, Sapa Jacek, Maciąg Dorota, Zygmunt Małgorzata, Antkiewicz-Michaluk Lucyna
    Źródło: Eur. J. Med. Chem. 2002: 37 (3) s.183-195, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 312,629

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: A series of 1-substituted pyrrolidin-2-one and pyrrolidine derivatives were syntheised and tested for electrocardiographic, antiarrhythmic, and antihypertensive activity as well as for ŕ1- and ŕ2-adrenoceptors binding affinities. Among the newly synthesised derivatives several compounds with 3-(4-arylpiperazin-1-yl)propyl moiety displayed strong antiarrhythmic (7a-12a) and antihypertensive (7a-11a) activities. Compound 11a, 1-[2-acetoxy-3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrrolidin-2-one, was the most potent in this series. The pharmacological results and binding studies that their antiarrhythmic and hypotensive effects may be related to their ŕ-adrenolytic properties, and that those properties depend on the presence of the 1-phenylpiperazine moiety with a methoxy- or chloro- substituent in the ortho position in the phenyl ring.


    618/2523

    Tytuł oryginału: Neonatal screening for cystic fibrosis.
    Autorzy: Dodge John A.
    Źródło: Pediatr. Pol. 2002: 77 (6) s.455-457, bibliogr. 9 poz.
    Sygnatura GBL: 301,294

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki


    619/2523

    Tytuł oryginału: The efficacy and safety of the tension-free vaginal tape procedure do not depend on he method of analgesia.
    Autorzy: Adamiak Aneta, Milart Paweł, Skorupski Paweł, Kuchnicka Katarzyna, Nestorowicz Andrzej, Jakowicki Jerzy, Rechberger Tomasz
    Źródło: Eur. Urol. 2002: 42 (1) s.29-33, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 312,572

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Objective: The oryginal tension-free vaginal tape (TVT) method, described by Ulmsten et al., routinely uses local anaesthesia during the procedure. Since the anaesthetic effect after local application of lidocaine hydrochloride was not always satisfactory we decided to introduce the spinal anaesthesia during this operation. The aim of the present study was to compare local and spinal anaesthesia with respect to their efficacy and safety in the TVT procedure. Methods: 103 women, with objectively confirmed stress urinary incontinence, were randomised into the study. Sixty-seven women were anaesthetised locally and 36 patients spinally. All TVT procedures were performed as originally described. Objective assessment of the influence of anaesthesia on intra-abdominal pressure at rest and during the cough test was done using a rectal catheter and a central venous pressure manometer. The efficacy of the TVT procedure was based on a gynaecological examination with a cough test and a three-degree subjective scale: complete cure, improvement or failure. Results: The success of the TVT procedure performed under local anaesthesia is a comparable with hat achieved under spinal analgesia (p = 0.42). The number of complications that occurred in the two groups does not differ significantly (p = 0.57). Conclusions: Spinal anaesthesia impairs the ability to cough effectively during the TVT procedure. However, the efficacy and safety of the operations performed under this type of anaesthesia are comparable with the efficacy and safety of operatins done under local anaesthesia.


    620/2523

    Tytuł oryginału: Cockroach allergy and exposure to cockroach allergen in Polish children with asthma.
    Autorzy: Stelmach I., Jerzyńska J., Stelmach W., Majak P., Chew G., Górski P., Kuna P.
    Źródło: Allergy 2002: 57 (8) s.701-705, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 302,302

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacgriund: Asthma morbidity increases every year, especially among children, and exposure to high levels of indoor allergens is a very important factor. We evaluated the prevalence and exposure to cockroach (CR) allergen in asthmatic children in Poland, and also tested the hypothesis that asthma with allergy to CR is more severe than with allergy to other antigens. Methods: One hundred and sixty children with asthma were examined, had skin prick tests (SPT) with common and CR allergens, underwent spirometry, and provocation tests to histamine. Children with positive SPT to CR had measured specific IgE levels to this antigen and Bla g 2 concentrations were measured in their homes. Results: The most common allergen, was dust mite 51.3 p.c., followed by pollen 48.8 p.c. and CR allergen 24.3 p.c. In children with CR sensitivity, 13 p.c. had mild ashma, 26 p.c. moderate and 61 p.c. had severe asthma. Their levels forced expiratory volume in one second (FEV1), and te provocative concentration of histamine that caused a 20 p.c. fall in FEV1 (PC20), were statistically lower than in the group of children with other than CR allergies. Bla g 2 antigen was detected in 55.13 p.c. samples. The highest levels of Bla g 2 were found in old houses, without central heating, and in houses with lower income. Conclusion: In Polish children, CR allergen is a very important factor of sensitivity. Concentratins of Bla g 2 in homes are higher than previously reported in other European countries, and are strongly related to the houses' characteristics. Also, children with CR hypersensitivity have severe asthma more often than children with other allergies.


    621/2523

    Tytuł oryginału: Urinary leukotriene levels are increased during exacerebation of atopic eczema/dermatitis syndrome. Relation to clinical status.
    Autorzy: Adamek-Guzik T., Guzik T. J., Czerniawska-Mysik G., Korpanty G., Mastalerz L., Radwan J., Szczeklik A.
    Źródło: Allergy 2002: 57 (8) s.732-736, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 302,302

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Leukotrienes are potent mediators of allergic inflammation and their role in the pathogenesis of allergic disorders, particularly asthma, is well established. Their importance in the pathogenesis of atopic eczema/dermatitis syndrome (AEDS) is still unclear. We aimed to compare urinary cysteinyl leukotriene (Cys-LT) levels during exacerbation and remission of AEDS in relation to clinical status, IgE levels, and eosinophil counts. Methods: Urinary Cys-LTs were measured by direct enzyme immunoassay in 17 adult patients with AEDS and in 17 healthy controls in whom atopy had been excluded. Cys-LTs were compared during exacerbation and remission of AEDS in relation to the clinical status measured by SCORAD. Total IgE levels were measured by enzyme-linked immunoassay (ELISA). Results: Mean clinical score during the exacerbation was 64.3 ń 3.1 and during remission 22.4 ń 4 (P 0.01). Cys-LTs were significantly higher during the exacerbation of AEDS than in the control group (230.9 ń 20.8 vs 123.2 ń 9.9 pg/mg creatinine; P 0.005). During the remission, the difference between AEDS patients and the control group was not significant (96.3 ń 8.7 vs 123.2 ń 9.9 pg/mg creatinine; P = 0.8). During AEDS exacerbation Cys-LTs levels were significantly correlated with the clinical status (rs = 0.73, P 0.01) and with eosinophil counts (r = 0.86; P 0.01) but not with the duration of the disease, age of patients, or IgE levels. Conclusions: Our results point to enhanced biosynthesis of Cys-LTs during the AEDS exacerbations. Inflammatory cells, e.g. eosinophilis are the most...


    622/2523

    Tytuł oryginału: Activity of class I, II, III, and IV alcohol dehydrogenase isoenzymes in human gastric mucosa.
    Autorzy: Jelski Wojciech, Chrostek Lech, Szmitkowski Maciej, Laszewicz Wiktor
    Źródło: Dig. Dis. Sci. 2002: 47 (7) s.1554-1557, tab., bibliogr. 19 poz.
    Sygnatura GBL: 310,037

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The gastric alcohol dehydrogenase (ADH) plays an important role in the "first pass" metabolism of ethanol. Human ADH exists in multiple forms, grouped into six classes and located in different tissues. In present study we investigated the activity of our four classes (I, II, III, and IV) of alcohol dehydrogenase isoenzymes in the different parts of stomach (corpus and antrum) in patients with suspected gastric ulcer. The aim of the study was assess the particular role of different classes of ADH in the gastric dehydrogenase actvity. For the measurement of the activity of class I and class II isoenzymes, we employed new fluorometric methods with specific substrates. The activity of class III alcohol dehydrogenase was measured by the photometric method with n-octanol and class IV with m-nitrobenzaldehyde as a substrate, respectively. All biopsy specimens were taken from less changed areas of the antrum and body of the stomach pof 68 patients suspected of having gastric ulcer. It was found that ADH IV (gastric) activity was the highest (14.76 ń 0.68 in the corpus of the stomach in men; and 7.61 ń 0.68 in women, respectively). The activity of the ADH III isoenzyme was lower than that of ADH IV. The activities of class I and II ADH isoenzymes were barely detectable. All tested classes of ADH had higher activity in the corpus than in the antrum and in males than in females. In conclusion, the most important form of gastric ADH is isoenzyme of class IV, less important is the isoenzyme of class III. ADH classes I and II seem to have no role in the stomach.


    623/2523

    Tytuł oryginału: Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes.
    Autorzy: Zbytek Błażej, Myśliwski Andrzej, Słomiński Andrzej, Wortsman Jacobo, Wei Edward T., Myśliwska Jolanta
    Źródło: Life Sci. 2002: 70 (9) s.1013-1021, il., bibliogr. 31 poz.
    Sygnatura GBL: 304,948

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: CRH cutaneous expression is significantly enhanced after exposure to various stimuli (Physiol Rev 2000,80;979-1020). We evaluated the effect of CRH on cytokine production in HaCaT keratinocytes, a cell line shown to express CRH receptors coupled to cAMP activation and calcium-dependent transmission pathways. It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11. It also inhibits production of IL-1beta and does not affect TNF-alpha production. Our results indicate that CRH functioh(s) during cutaneous stress may be mediated by differential effects on cytokine production.


    624/2523

    Tytuł oryginału: Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice.
    Autorzy: Kurkowska-Jastrzębska I., Babiuch M., Joniec I., Przybyłkowski A., Członkowski A., Członkowska A.
    Źródło: Int. Immunopharmacol. 2002: 2 (8) s.1213-1218, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,577

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The anti-inflammatory agents are postulated to be effective in treating neurodegenerative disorders. In this study, we showed that indomethacin (IND) in the dose of 1 mg/kg protected neurons against toxic damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice model of Parkinson's diseases. IND also diminished microglial activation and lymphocytic infiltration in the injured areas. These observations suggest that anti-inflammatory properties of IND may play a role in the neuron's protection in this model. However, diminished inflammatory reaction may be secondary to less neuronal damage.


    625/2523

    Tytuł oryginału: Concentration and composition of free ceramides in human plasma.
    Autorzy: Górska M[aria], Dobrzyń A., Żendzian-Piotrowska M., Namiot Z.
    Źródło: Horm. Metab. Res. 2002: 34 (8) s.466-468, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 312,226

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    626/2523

    Tytuł oryginału: Biological properties of a new fluorescent biphalin fragment analogue.
    Autorzy: Lipkowski Andrzej W., Misicka Aleksandra, Kosson Dariusz, Kosson Piotr, Lachwa-From Magdalena, Brodzik-Bieńkowska Agnieszka, Hruby Victor J.
    Źródło: Life Sci. 2002: 70 (8) s.893-897, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 304,948

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Previous studies of stsurcture-activity of biphalin defined fragments which expressed the full biological potency of the parent compound. The most simple fragment was Tyr-D-Ala-Gly-Phe-NH-HH - X, where X = Phe, but it also could be other hydrophobic amino acids. This paper presents data that replacement of the phenylalanine with a dansyl (X = DNA) groups gives an analogue (AA20116) that fully preserves the high affinity of the initial analogue for both ć and ë opiioid receptors. In the tail flick test in rats, intrathecal injection of the compound produces strong antinociception, comparable to the parent biphalin. Cecause AA2016 contains a strong fluorescent group, it can be a very useful tool for prospective studies in vivo, including biological barrier permeability, tissue distribution, metabolism and receptor-ligand complex formation.


    627/2523

    Tytuł oryginału: Superficialization of the wrist native arteriovenous fistula for effective hemodialysis vascular access construction.
    Autorzy: Weyde Wacław, Krajewska Magdalena, Letachowicz Waldemar, Klinger Marian
    Źródło: Kidney Int. 2002: 61 (3) s.1170-1173, il., bibliogr. 10 poz.
    Sygnatura GBL: 312,423

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background. It is commonly known that the best type of vascular access for chronic hemodialysis, defined as the one with the lowest number of complications and longest use, is the primary (Brescia-Cimino) radiocephalic fistula. One reason for the impossibility of its creation is that the vein vessel on the forearm is located too deeply, which is primarily caused by the patients' obesity. Methods. In 24 obese patients the superficialization procedure of the venous part of fistula under the skin was performed. Results. In 23 patients of this group, an easy and uncomplicated fistula puncturing was achieved. One patient had the complication of fistula clotting. Conclusion. Subcutaneous transposition of the arterialized median antebrachial vein is a simple and effective method of an adequate distal native fistula creation in patients with deeply located forearm veins.


    628/2523

    Tytuł oryginału: Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine faschion enhances cell proliferation and expression of Bcl-xL and Bcl-2.
    Autorzy: Kurowska Mariola, Rudnicka Weronika, Kontny Ewa, Janicka Iwona, Chorazy Magdalena, Kowalczewski Jacek, Ziółkowska Maria, Ferrari-Lacraz Sylvie, Strom Terry B., Maśliński Włodzimierz
    Źródło: J. Immunol. 2002: 169 (4) s.1760-1767, il., bibliogr. 49 poz.
    Sygnatura GBL: 300,982

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The hallmarks of rheumatoid arthritis (RA) are leukocytic infiltratin of the synovium and expansiveness of fibroblast-like synovicytes (FLS). The abnormal proliferation of FLS and their resistance to apoptosis is mediated, at least in part, bay present in RA joints proinflammatory cytokines and growth factors. Because IL-15 exerts properties of antiapoptotic and growth facators, and is produced by RA FLS, we hypothesized that IL-15 participates in RA FLA activation. To test this hypothesis, we first examined whether RA FLS express chains required for high affinity functional IL-15R. Indeed, RA FLS express IL-15Rŕ at mRNA and protein levels. Moreover, we confirmed the presence of IL-2Rá and common ç-chains. Interstingly, TNF-ŕ or IL-1á triggered significant elevation of IL-15Rŕ chanin at mRNA and protein levels. Next, we investigated the effects of exogenous or endogenous IL-15 on Bcl-2 andBcl-XL expression, FLS proliferation, and apoptosis. Exogenous IL-15 enhanced RA FLS proliferation and increased the level of mRNA-encoding Bcl-XL. To test the role of endogenous IL-15 in the activation of RA FLS, an IL-15 mutant/Fcç2a protein exerting properties of specific antagonist to the IL-15Rŕ chain was used. We found that blocking IL-15 biological activities using this protein substantially reduced endogenous expression of Bcl-2 and Bcl-XL, and RA FLA proliferation that was reflected by increased apoptosis. Thus, we havae demonstrated that a distinctive phenotype of RA FLS, i.e., persistent activation, proliferation, and resistance to apoptosis, is related to the autocrine activation of IL-15Rs by FLS-derived IL-15.


    629/2523

    Tytuł oryginału: The mechanism of the hemolytic activity of polyene antibiotics.
    Autorzy: Knopik-Skrocka Agnieszka, Bielawski Józef
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.31-48, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The kinetics of the filipin-, amphotericin B- and nystatin-induced hemolysis of human erythrocytes were investigated. Filipin-induced hemolysis is of the damage type. It is an all-or-none process, partly inhibited by Ca2+ or Ba2+ abut not bay Mg2+, Na+ or SO42-. The hemolytic activity of filipin is explained by the formation of large aggregates within the erythrocyte membrane in the form of large perforations, permeable to substances of low molecular weight as well as to macromolecules, including hemoglobin. In isotonic KCl solution, both amphotericin B and nystatin, at low concentrations, form smaller aggregates within the membranes. As a result, the permeabiality of teh membranes to KCl increases and hemolysis occurs. However, the kinetics of the hemolysis induced by the two polyenes is complex. The process shows some features of the permeability type and some of the damage type. It is suggested that amphotericin B and nystatin may simultaneously form a number of transport systems, differing in their molecular organisation and hemolytic activity. Their participation in erythrocyte membrane permeability can be modified by small changes in membrane organisation and the chemical composition of the incubation medium. In isotonic solutions of divalent cation chlorides, and at higher antibiotic concentration, additional aggregates, allowing divalnt cations to permeate, appear. These structures do not permit SAO42- to permeate.


    630/2523

    Tytuł oryginału: The International Confrence on Life Sciences - 2001, September 22.-26.2001, Gozd Martuljek, Slovenia.
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.69-174, il., tab., bibliogr. [przy ref.] - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    631/2523

    Tytuł oryginału: The biomechanics of standing and balancing in paralyzed people.
    Autorzy: Bajd Tadej, Mihelj Matjaz, Matjacić Zlatko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.74-77, tab., bibliogr. 6 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Prolonged immobilization results in several physiological problems. It has been demonstrated that standing exercises can ameliorate many of these problems. Standing exercises can be performed efficiently with the help of functional electrical stimulation (FES). A novel robotic mechanism which aids the unsupported standing of paraplegics, providing balancing exercise has been developed. The balancing strategy is based on voluntary activity of the paraplegic's upper body and artificially controlled stiffness in the ankles.


    632/2523

    Tytuł oryginału: Magnetic resonance imaging of arterial thrombi and its possible correlation to fibrinolytic treatment.
    Autorzy: Kozak Matija, Blinc Ales, Sersa Igor, Mikac Ursa, Surlan Milos
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.82-86, il., tab., bibliogr. 7 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: For 13 patients with subacute and 4 patients with chronic occlusion, magnetic resonance imaging (MRI) of occlusive arterial thrombi in the superficial femoral artery were performed in vivo. The patients with subacute occlusion were treated with cetheter-directed thrombolysis. The frequency of MR signal intensity and its distribution in thrombi were studied for 11 successully adn 2 unsuccessfully treated patients and patients with chronic occlusion. Intra-araterial thrombi were MRI inhomogenous in all of the patients, abut the MR signals from lysable and chronic thrombi were significantly different than those from nonlysable ones. The MRI of occusive arterial thrombi is probably usaable to predict the therapeutic outcome of thrombolytic treatement.


    633/2523

    Tytuł oryginału: Structural studies on membrane proteins using non-linear spin label EPR spectroscopy.
    Autorzy: Pali Tibor, Marsh Derek
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.87-91, il., bibliogr. 11 poz. - Międzynarodow konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Non-linear electron spin resonance (EPR) techniques suitable for measuring proximity relationships in membranes are reviewed. These were developed during the past decade in order to measure changes sensitively in the spin-lattice relaxation time (T1) of nitroxyl spin labels covalently attached to membrane lipids or proteins. In combination with paramagnetic quenching agents and double spin-labelling, the methods were further developed for distance measurements. Selected examples are given to illustrate different methods, and types of data obtained for both integral and peripheral membrane.


    634/2523

    Tytuł oryginału: Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability.
    Autorzy: Potocnik Uros, Ravnik-Glavac Metka, Glavac Damjan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.93-95, tab., bibliogr. 7 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • genetyka
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The multidrug resistance 1 (MDR) gene and transcription factor 4 (TCF4) gene are suggested to be involved in the WNT signalling pathwey, the most important patway altered in colorectal cancer. Mutations in both genes have been identified and associated with colorectal tumors exahibiting high microsatellite instability (MSI-H). In this study, we report on the distribution of functional polymorphism in the MDR1 gene and somatic frameshift mutations in the TCF4 gene coding mononucleotide repetition in 62 MSI-H colorectal tumors. Somatic frameshift mutations in(of) the TCF4 gene were identified in 24/62 (39 p.c.) of the studied MSI-H tumors. The estimatd allele frequencies of functional polymorphisms in(of) exon 21 (2677 G T, Ala893Ser) and exon 26 (3435 C T, Ile1142Ile) of the MDR1 gene were 0.42 and 0.46 in the controls and 0.54 (p = 0.035) and 0.60 (p = 0.017) in the MSI-H tumors. However, the allele frequency of both functional MDR1 polymorphisms did not significantly differ between MSI-H tumors with TCF4 mutations and those without. These results support the involvement of the MDR1 gene in the tumorgenesis of MSI-H tumors and also suggest that functional polymorphisms in the MDR1 gene and mutations in the TCF4 gene are likely to occur independently in MSI-H tumors.


    635/2523

    Tytuł oryginału: A generalized mathematical model of biological oscillators.
    Autorzy: Ton-That Tuong
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.101-104, bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: Biological rhythms such as circadian rhythms, biochemical rhythms and neural oscillators are based on the mathematical model of the theory of harmonic oscillators. These are solutions of certain second-order differential equations. They can also be viewed as spherical harmonics on the circle in the two-dimentsional Euclidean space. The sphrerical harmonics on (n = 1)-spheres and, more generally, the Stiefel harmonics can represent oscillatory phenomena, and we expect that they can serve as models for more complex biological rhythms.


    636/2523

    Tytuł oryginału: Intravascular plug formation induced by poly-APS is the principal mechanism of the toxin's lethality in rats/rat tissues.
    Autorzy: Bunc Matjaz, Sarc Lucija, Rozman Janez, Turk Tom, Sepcic Kristina, Suput Dusan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.106-108, bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Toxic water solubale polymeric 3-alkylpyridinum salts isolated from the sponge Raniera sarai strongly inhibited AChE in vitro. In vivo, experimental animals died due to plugs formed in microcirculation. The mechanism of this plug formation is unknown. In vitro, the toxin did not affect the coagulation rate, but the rate of platelet aggregation was accelerated in a dose-dependent manner. The hemolytic activity of poly-APS was diminishe by the addition of serum proteins in a dose-dependent manner. These results support the conclusion that non-specific bainding to proteins is the underlying mechanism of the lethality of poly APS.


    637/2523

    Tytuł oryginału: The influence of the biomechanical parameters of the hip on the outcome of treatment of hips subject to avascular necrosis of the remoral head.
    Autorzy: Dolinar Drago, Kralj-Iglic Veronika, Iglic Ales, Antolic Vane, Herman Srecko, Pavlovcic Vinko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.109-111, il., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca związana ze zjazdem
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We were interested in whether or not the biomechanical status of the hip influences the course of avascular necrosis of the femoral head. To invaestigate this, we used a computer aided system based on a three dimensional mathematical model for determining the stress distribution in the hip joint from standard anterioposterior rentgenographs(X-ray images) of both hips and pelvis. Based on the results of our study, we suggest that the biomechanical parameters of the hip play an important role in the outcome of treatment of hips affected by avascular necrosis of the femoral head.


    638/2523

    Tytuł oryginału: Examination of fragment dose contribution in heavy ion radiotherapy.
    Autorzy: Giacomelli Marko, Ilic Radomir, Skvarc Jure
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.112-114, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: Heavy-ion radiotherapy is an efficient mthod for the treatment of deep-seated tumors, because the stopping of ions in a tissue delivers the maximal absorbed dose to the tumor-affected areas with minimal damage to the healthy tissues. However, heavy ions can undergo nuclear reactions, giving products with lower Z-values and hence a longer range in the tissue. This causes a dose increase beyond the mean range of the primary beam. The contribuation of such reaction products was examined in an experiment where a stack of tissue-like targets interleaved with CR-39 etched traack detectors (ETD) was irradiated with heavy ions. The analysis was performed using a recently developed technique of trajectory tracing, which enables the spectroscopy of fragments with different Z-values.


    639/2523

    Tytuł oryginału: Frequency encoding of intracellular Caý+ signals.
    Autorzy: Grubelnik Vladimir, Marhl Marko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.115-117, il., bibliogr. 6 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: In a very recent theoretical study [1], we showed that simple mitochondrial kinetics, originally proposed by Marhl et al. [2], could be easily used as a plug-in element in other models desribing intracellular Ca2+ dynamics. We analysed several previously published models and showed that mitochondrai could indeed maintain the constant amplitude of intracellular Ca12+ oscillations very effectively. We also pointed out the importance of amplitude regulation for the frquency encoding of intracaellular Ca2+ signals. This paper focuses on giving a more exhaustive demonstration of this phenomenon of frequency encoding for the model of Dupont et al. [3].


    640/2523

    Tytuł oryginału: Cyclophosphamide metabolites perforate the apical plasma membranes of urothelial cells in rats.
    Autorzy: Koprivec Dasa, Jezernik Kristijan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.123-125, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The apical plasma membrane of differentiated superfical urothelial cells is characterised by the presence of asymmetric unit membrane (AUM). Cyclophsphamide (CP) metaabolites cause perforation of these thickened membranes. In this study, apical plasma membranes were examined after CP injection by electron microscopy. The immediate effect of the CP metabolites was observed as small round holes appearing, first in the asymmetric apical plasma membrane of terminally differentiated superficail cells, and later in the symmetric apical plasma membrane of exposed undifferentiated intermediate and basal cells. Exposed cells which remained undamaged, immediately underwent maturation of the symmetric apical plasma membarane. These results indicate that CP metabolites perforate the symmetric and asymmetric membranes of most urothelial cells.


    641/2523

    Tytuł oryginału: The small world in biophysical systems structural properties of glycolysis and the TCA cycle in Escherichia coli.
    Autorzy: Krajnc Borut, Marhl Marko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.129-131, tab., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: It has been shown that the central metabolic network of Escherichia coli is of the small-world type. In this paper, we present that the metabolic network of glycolysis and TCA cycle as a part of the E. coli metabolism is also a small-world network. We found that the hubs of the studied network are consistent with those found in the complete metabolic network. The evolutionary meaning of this finding is discussed.


    642/2523

    Tytuł oryginału: Sphericity of the femoral head on anterior-posterior radiographs of dysplastic hips.
    Autorzy: Mavcic Blaz, Antolic Vane, Iglic Ales, Kralj-Iglic Veronika
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.132-133, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We analyzed the spehericity of the femoral head of dysplastic hips. Using standard anterior-posterior radiographs of the hips, we assessed the femoral head's deviation from a spherical shape using a computer algorithm and via Severin grading. The method presented could serve as a useful tool to quantify differences in sphericity in cases where it is difficult to grade the hip radiologically.


    643/2523

    Tytuł oryginału: Electric current density imaging of tablet dissolution.
    Autorzy: Mikac Ursa, Demsar Alojz, Sersa Igor, Demsar Franci
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.136-138, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: The Electric current density imaging technque (CDI) was used to monitor the dissolution of and ion migration from tablets of different acids in agar-agar gel. Conventional MRI cannot monitor these processes, since it can only show changes in the size of the tablet during the dissolving process. CDI traces the dissolfed ions thanks to changes in conductivity.


    644/2523

    Tytuł oryginału: Renal injuries induced by chronic intoxication with microcystins.
    Autorzy: Milutinovic Aleksandra, Sedmak Bojan, Horvat-Znidarsic Irena, Suput Dusan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.139-141, il., bibliogr. 2 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The microcystins (MCs) LR and YR are hepatoxins produced by some species of freshwater cyanobacteria. Only a few reports on the acute nephrotoxicity of MCs have been published to date. Here we investigate the effecats on rat kidneys of chronic administration of relatively low doses of MC LR and MC YR. Male Wistar rats wer injected every second day for 8 months with MC LR (10 ćg/kg i.p., n = 5) and MC YR (10 ćg/kg i.p., n = 5). The control group was treated with vehicle, a mixture containing 0.8 p.c. ethanol and 0.2 p.c. methanol in 0.9 p.c. saline (3.7 ml/kg i.p., n = 5). We found that MCs could induce damage to the kidney cortex and medulla. The lesions mainly consisted of damaged and dilated tubuli filled with homogenous eosinophil material. We conclude that long-term exposure to relatively low doses of MCs poses a considerable risk for kiney injury.


    645/2523

    Tytuł oryginału: EPR spectroscopy of common nitric oxide - spin trap complexes.
    Autorzy: Nedeianu Saviana, Pali Tibor
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.142-143, bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: Two commonly used hydrophobic and hydrophilic spin traps for NO, namely Fe2+ (DETC)2 and Fe2+ (MGD)2, respectively, were analyzed via EPR spectroscopy. EPR spectra of trapped NO, together with field position standards, were recorded both in the frozen state and at room temperature. We present a detailed characterization of the EPR spectra of the above paramagnetic NO complexes, concerning g-value, hyperfine splitting and linewidths. This study also provides spectroscopic data required to develop a quantitative and sensitive detection system for nitric oxide both in hyrophobic and hydrophilic aqueous media.


    646/2523

    Tytuł oryginału: How should dysplastic human hips be evaluated?
    Autorzy: Pompe Borut, Antolic Vane, Iglic Ales, Jaklic Anton, Kralj-Iglic Veronika, Mavcic Blaz
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.144-146, tab., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Dysplasia of the human hip is characterised bay insufficient anterolateral covering of femoral head by the acetabulum. In our study, we evaluated dysplastic human hip joints using biomechanical parameters (the peak contact stress in the weight-bearing area of the hip - pmax) and X-ray image parameters (the centre-edge angle - VCE, the transverse acetabular inclination angle - VUS, the acetabaular index of the weight-bearing zone - VAC, the ACM angle - VACM, and the hip value - HV). The purpose of this study is to make use of X-ray and biomechanical parameters to evaluate hips diagnosed with "hip dysplasia", and to establish whether or not ther is a correlation between the two. Our results show a statistically significant correlation between pmax and VCE, VUS and VAC. The correlation between pmax and VACM and HV is not statistically significant.


    647/2523

    Tytuł oryginału: The relationship between innervation density and dynamic balance function.
    Autorzy: Rugelj Darja
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.149-150, bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Functional reach (FR) significantly increases with additional sensory information from the fifth metacarpal surface of the dominant hand. The purpose of this study was to determine the relationship between the innervation density of the skin above the fifth metacarpal surface of the palm and the increase of FR with an additional light touch. The results show a moderate negative correlation between innervation density and the increase of FR with light touch.


    648/2523

    Tytuł oryginału: The influence of amino acaid side chains on water binding to the copper(II) in bis(N,N-dimethyl-L-ŕ-isoleucinato)-copper(II): and EPR and molecular mechanics study.
    Autorzy: Sabolovic Jasmina, Noethig-Laslo Vesna
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.151-153, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: Simulations were done of the electron paramagnetic resonance (EPR) spectra for bis(N,N-dimethyl-L-ŕ-isoleucinato)copper(II) dissolved in deuterated methanol as a function fo temperature. They indicated different behaviour of the complex below and above 300řK. The effect was examined by the conformational analysis of the copper(II) complex with a new molecular mechanics force field.


    649/2523

    Tytuł oryginału: Quantification of the MR images of hydrogels by NMR relaxation measurements.
    Autorzy: Sepe Ana, Baumgartner Sasa, Kristl Julijana, Lahajnar Gojmir, Jarh Orest
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.154-156, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • farmacja
  • radiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: Layers of hydrogael respresent a diffusional barrier that retards the process of drug release. For better prediction of drug release, a method for evaluating the polymer concentration profile was developed.


    650/2523

    Tytuł oryginału: Heart rate variability - a shape analysis of lorenz plots.
    Autorzy: Sevsek France, Jakovljevic Miroljub
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.159-161, bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: A new quantitative geometrical method to analyse heart rate variability is presented. The standard image analysis techniques were applied to the grey scale images of Lorenz plots, and the outlines of the attractor areas were determined via a contour following procedure based on a maze walking algorithm. For graphs of simple compaact shape, the attractor region contours were described in terms of Fourier coefficients.


    651/2523

    Tytuł oryginału: Selective radigraphy of 10B distribution in organs using cold and thermal neutron beams.
    Autorzy: Skvarc Jure, Giacomelli Marko, Yanagi‰ Hironobu, Khne Guido
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.162-164, il., bibliogr. 2 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The investigation of boron biodistribution by neutron induced autoradiography was performed using a CR-39 etched track detector. Calibration samples, made of boronated chicken liver, and freeze-dried mouse tissue samples were irradiated both with thermal and cold neutrons. Digital images were made on the basis of track densities, with the selection of tracks due to 10BB(n, ŕ)7Li reaction. A comparison of results obtained both with thermal and cold neutrons demonstrated that it is possible to obtain equivalent results with both neutron sources, although the background noise due to recoil protons from the fast neutrons of the thermal neutron source is 15 p.c. higher than that of the cold neutron source. 10B concentrations in the range of 0.5 ppm to 150 pm were determined, with a standard deviation of 13 p.c. and 8 p.c. for the mouse tissue samples and calibration samples, respectively.


    652/2523

    Tytuł oryginału: The influence of Na+ ions on histamine secretion from mast cells induced by NGF or compound 48/80.
    Autorzy: Stempelj Mateja, Carman-Krzan Marija, Ferjan Ilonka
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.165-166, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: It has been demonstrated that the release of histamine from mast cells by cytokines is strongly dependent on extracellular Ca2+ and Na+ ions. The results of our current research indicate that the removal of extracellular Na+ enhances NGF induced histamine release, but reduces induction by compound 48/80, suggesting that different mechanisms ar involved in the secretory process induced bay these agents.


    653/2523

    Tytuł oryginału: The effect of proprioceptive training on neuromuscular function in patients with patellar pain.
    Autorzy: Strojnik Vojko, Vengust Rok, Pavlovcic Vinko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (1) s.170-171, il., bibliogr. 2 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze 2001 Gozd Martuljek 22-26.09. 2001
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Eight patients with patellar pain underwent knee proprioceptive training. The maximal knee extension torque associated with the Vastus Lateralis EMG signal increased (p 0.001 and 0.039). Although muscle balance was not improved, all the patients improved their clinical scores.


    654/2523

    Tytuł oryginału: Disposition and metabolism of 1,6-dimethylnaphthalene in rats.
    Autorzy: Kilanowicz Anna, Sapota Andrzej, Czerski Bogdan
    Źródło: Toxicol. Lett. 2002: 134 (1/3) s.227-243, il., tab., bibliogr. [18] poz.
    Sygnatura GBL: 306,158

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The distribution, excretion and metabolism of 1,6-dimethylnaphthalene following i.p. administration of a single dose of 20 mg/kg to rats, was investigated using radiotracer [3H] and a gas chromatography - mass spectrometry technique (GC-MS). After 72 h, about 94 p.c. of the given dose was excreted in urine and feces. In organs and tissues, the highest concentration during the first hours after administration was detected in fat, liver, spleen and kidneys. Then gradual decline of tritium was noticed in all examined tissues. In urine, the following substanceswere identified and quantified by GC peak areas: unchanged 1,6-dimethylnaphthalene, 1-methyl-hydroxynaphthalenes, 1-hydroxymethyl-6-methylnaphthalene, 1,6-dimenthyl-thionaphthalene, 6-methyl-1-naphthoic aldehyde, 6-methyl-1-naphthoic acid, 1,6-dimethyl-thionaphthalene and 1,6-dimethyl-methylthionaphthalene.


    655/2523

    Tytuł oryginału: Acute and subacute nephrotoxicity of 2-bromophenol in rats.
    Autorzy: Bruchajzer Elżbieta, Szymańska Jadwiga A., Piotrowski Jerzy K.
    Źródło: Toxicol. Lett. 2002: 134 (1/3) s.245-252, il., tab., bibliogr. [24] poz.
    Sygnatura GBL: 306,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: The present report aims at providing broader information on the acute nephrotoxicity of 2-bromophenol (2-BP) (a bromobenzene (BB) metabolite), due to its action on the kidneys, after repeated administration. Investigations were performed on female rats. Following a single dose, the most pronounced changes involved: concentrations and rates of excretion of proteins in urinwe, the number of epithelial cells excreted in urine, creatinine and urea clearance and reduced gluthione in renal tissue. Immediate effects could be ascribed to both renal tubules and glomeruli, mirrored in the level of urinary proteins and intensified excretion of renal epithelial cells. Less pronounced changes of the indicator values were noted under repeated dosing of 2-BP. The results obtained in a single exposure study confirm earlier on the mild nephrotoxicity of 2-BP following exposure to high doses. However, the transition from single to repeated expopsure does not result in enhanced nephrotoxicity.


    656/2523

    Tytuł oryginału: Relationship between hyperinsulinemia and angiographically defined coronary atherosclerosis in non-diabetic men.
    Autorzy: Kruszelnicka-Kwiatkowska O., Surdacki A., Goldsztajn P., Matysek J., Piwowarska W., Golay A.
    Źródło: Diabetes Metab. 2002: 28 (4 c. 1) s.305-309, tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,123

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background. Our aim was estimate the relationship between hyperinsulinemia and angiographically validated coronary atherosclerosis. Methods: 102 consecutive non-diabetic male subjects (age 48.9 ń 9.6 years) with a body mass index 25.9 ń 2.8 kg/mý referred to coronary angiography in our centre were studied. A 75-g oral glucose tolerance test (OGTT) was performed and the areas under the curve (AUC) of serum insulin and glucose were calculated. Results: Discriminant analysis with stepwise forward variable selection revealed that in younger patients ( 50 years), the following parameters affected positively the number of significant coronary lumen reductions: age (F = 8.5, p = 0.005). InAUCinsulin (F = 5.8, p = 0.02), low HDL cholesterol (F = 4.4, p =n 0.04), the smoking habit (F = 4.1, p = 0.05). In those 50 years of age, exclusively age (F = 5.8, p = 0.02) and hyperuricemia (F = 3.8, p = 0.06) entered of the final model. Conclusion: Our results indicate that in non-diabetic male subjects the association of hyperinsulinemia with the severity of coronary arterosclerosis is only seen in younger patients.


    657/2523

    Tytuł oryginału: Synchytrium endobioticum and its potential role in carcinogenesis
    Autorzy: Marcinkowski Tadeusz
    Źródło: - Goleniów, Oficyna Wydaw. "BIOS" 2002, 25 s. : il., bibliogr. 4 poz., 21 cm.
    Sygnatura GBL: 660,759

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia

    Typ dokumentu:
  • praca historyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Łuczyński
  • Stanisław 1902-1971


    658/2523

    Tytuł oryginału: In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors.
    Autorzy: Grabarek Jerzy, Darzynkiewicz Zbigniew
    Źródło: Exp. Hematol. 2002: 30 (9) s.982-989, il., bibliogr. 60 poz.
    Sygnatura GBL: 305,749

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Activation of caspases is the key event of apoptosis. To detect this event in situ we applied fluorochrome-labeled inhibitors of caspases (FLICA) as affinity of activity centers of these enzymes. The FLICA are fluoroscein- or sulforhodamine-conjugated peptide-fluoromethyl ketones that covalently, with 1:1 stoichiometry, bind to enzymatic centers of caspases; the specifity is provided by the peptide sequence of amino acids. Similarly, we applied fluorescent inhibitors of serine proteases (FLISP) to detected activite sites of the latter enzymes. Exposure of live cells to FLICA of FLISP led to uptake of these ligands and their binding to activated caspases or active sites og serine proteases; the unbound reagents were removed by cell rinse. Only cells undergoing apoptosis were labeled with FLISP or FLICA. Intracellular binding sites of FLICA are consistent with known localization of caspases. Covalent binding of FLICA or FLIPPS allowed us to identify the labeled proteins by immunoblotting: the proteins that bound individual FLICAs had molecular weight between 17 and 22 kDa, which corresponds to large subunits of the caspases; two proteins reacting with FLISP were about 57 and 60 kDa, which suggests that they are novel enzymes. Detection of caspases or serine proteases activation can be combined with other markers of apoptosis or cell cycle for multiparametric analysis by flow or laser ascanning cytometry. Being caspases inhibitors, FLICA arrest the process of apoptosis and prevent cell distintegration. The stathmo-apoptotic assay was developed...


    659/2523

    Tytuł oryginału: Gastric syphilis - a case report.
    Tytuł polski: Kiła żołądka - opis przypadku.
    Autorzy: Poniewierka Elżbieta, Paradowski Leszek, Sajewicz Zbigniew, Jeleń Michał
    Źródło: Gastroenterol. Pol. 2002: 9 (1) s.71-73, il., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 313,180

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Kiłowe zapalenie żołądka jest obecnie rozpoznawane bardzo rzadko. Objawy kliniczne i wyniki endoskopii często wskazują na raka żołądka lub chłoniaka. Rozpoznanie jest często przypadkowe, wsparte pozytywnymi wynikami testów serologicznych w kierunku zakażenia kiłowego.

    Streszczenie angielskie: Syphilitic gasttritis is now recognized extremely rarely. Clinical symptoms and endoscopic findings are not characteristic and often suggest gastric carcinoma or lymphoma. Diagnosis is often casual, supported by positive findings of common serologic tests for syphilis.


    660/2523

    Tytuł oryginału: Endothelin-1 (ET-1) as a mediator of pregnanycy induced hypertension (PIH).
    Autorzy: Heimrath Jerzy, Krawczenko Agnieszka, Duś Danuta
    Źródło: Ginekol. Pol. 2002: 73 (6) s.512-516, il., tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 301,184

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie polskie: Występowanie nadciśnienia indukowanego ciążą (PIH - pregnancy induced hypertension) jest związane z uszkodzeniem i następującą aktywacją komórek śródbłonka naczyniowego łożyska. Aktywowane komórki śródbłonkowe produkują cały szereg mediatorów, wśród których na szczególną uwagę zasługuje endotelina-1 (ET-1) - jeden z głównych czynników wywołujących skurcz naczyń. Celem naszych badań było określenie poziomu ET-1 w surowicy 18 pacjentek z PIH w porównaniu z grupą 16 zdrowych ciężarnych. Poziom ET-1 mierzono testem ELISA. Stwierdzono statystycznie istotną różnicę poziomu ET-1 pomiędzy badanymi grupami, który wynosił, odpowiednio, 33,00 ń 12,07 vs. 25,00 ń 5,69 pg/mL (p = 0,005). Z obserwacji powyższej wynika, że podwyższony poziom endoteliny u kobiet ciężarnych mógłby być wczesnym markeremm nadciśnienia indukowanego ciążą.

    Streszczenie angielskie: Pregnancy induced hypertension (PIH) is accompanied by injury and further activation of placental endothelial cells. Activated endothelial cells produce several mediators, among them endothelin-1 (ET-1) - one of the most potent vasoconstrictors. The aim of the study was to examine the ET-1 level in serum of 18 women with PIH and compare it to the group of 16 normotensive pregnant women. ET-1 level, as evaluated by ELISA test, was significantly higher in PIH than in normotensive pregnancy, 33.00 ń 12.07 vs. 25.00 ń 5.69 pg/mL (p = 0.005), respectively. It might be concluded, that ET-1 level is a prognostic parameter, indicating the possibility of PIH development.


    661/2523

    Tytuł oryginału: Integrated minimally invasive direct coronary artery bypass grafting and angioplasty for coronary artery revascularization.
    Autorzy: Cisowski Marek, Morawski Włodzimierz, Drzewiecki Janusz, Kruczak Wojciech, Toczek Krzysztof, Bis Jarosław, Bochenek Andrzej
    Źródło: Eur. J. Cardiothorac. Surg. 2002: 22 (2) s.261-265, tab., bibliogr. 20 poz.
    Sygnatura GBL: 312,899

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: Minimally invasive direct coronary artery bypass (MIDCAB) through the anterolateral minithoractomy has become a promising therapeutic option in patients with lesion in left anterior descending artery (LAD), especially in multimorbid, elderly and reoperated patients with type C or B lesions. To expand the benefits of MIDCAB concept to patients with multivessel disease, a hybrid myocardial revascularization procedure (HMR) combining surgery of the LAD with interventional proedures for additional coronary lesions has recently been introduced. Methods: Between January 1999 and September 2001, 50 patients (37 male, 13 female, mean age 54.8 ń 20.1 years) underwent an HMR procedure. MIDCAB with endoscopic left internal thoracic artery (LITA) harvesting, followed by percutaneous coronary intervention (PCI) for additional coronary lesions and percutaneous transluminal coronary angioplasty (PTCA), was performed in 11 patients (22 p.c.) and stenting in 39 patients (78 p.c.). Angiographic assessment of graft patency was performed in all patients during the PCI procedure. The clinical follow-up period was 3-32 months. Results: There were no early and late deaths. Baseline Canadian Cardiology Society (CCS) class was 2.8 ń 0.7 versus 1.1 ń 0.9 (P 0.001) 30 days after HMR procedure. There were no major acute inhospital cardiac events. Angiographic studies showed patent LIMA-LAD graft in 50 patients (100 p.c.). We showed quality of anastomosis in 49 patients (98 p.c.). There was a moderate graft stenosis in one ...


    662/2523

    Tytuł oryginału: Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis.
    Autorzy: Klimiuk P. A., Sierakowski S., Latosiewicz R., Cylwik J. P., Cylwik B., Skowroński J., Chwiecko J.
    Źródło: Ann. Rheum. Dis. 2002: 61 (9) s.804-809, il., tab., bibliogr. 46 poz.
    Sygnatura GBL: 310,264

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Cell adhesion molecules and endothelial growth factors have an important role in the infiltrating of rheumatoid synovium with mononuclear cells, leading to the initiation and progression of the disease. Objective: To investigate whether the serum profile of soluble adhesion molecules and of vascular endothelial growth factor (VEGF) is associated with the histological apperance of rheumatoid arthritis (RA). Methods; Serum levels of soluble intercellular adhesion molecule-1 (slCAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin), and VEGF were assessed by enzyme linked immunosorbent assay (ELISA) in 40 patients with RA and 32 patients with osteoarthritis (OA). Results: Histological analysis of synovium specimens distinguished two types of rheumatoid synovitis. Twenty four RA samples presented diffuse infiltrates of mononuclear cells without any further microanatomical organisation, whereas in the remaining 16 samples lymphocytic follicles with germinal centrelike structures were identified. In comparison with patients with OA, constituting a control group, higher serum concentrations of slCAM-1 (p 0.001), sE-selectin (p,0.01), and VEGF (p0.001) were detected in patients with RA. Raised concentrations of slCAM-1, and VEGF dominated in the serum of patients with RA with follicular synovitis compared with those with diffuse synovitis (p 0.01 for all comparisons). The serum concentrations of slCAM-1, sVCAM-1, and VEGF correlated with markers of disease activity such as the erytchrocyte sedimentation rate and C reactive ...


    663/2523

    Tytuł oryginału: Genetics of human essential hypertension.
    Autorzy: Jeunemaitre Xavier
    Źródło: Kardiol. Pol. 2002: 56 supl. 1: 5 Sympozjum Sekcji Kardiologii Doświadczalnej Polskiego Towarzystwa Kardiologicznego "Nadciśnienie tętnicze" s.I-47 - I-50, bibliogr. 25 poz. - 5 Sympozjum Sekcji Kardiologii Doświadczalnej Polskiego Towarzystwa Kardiologicznego pt. Nadciśnienie tętnicze Konstancin 12. 2000
    Sygnatura GBL: 313,397

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    664/2523

    Tytuł oryginału: Contact guidance of Walker carcinosarcoma cells by the underlying normal fibroblasts is inhibited by RGD-containing synthetic peptides.
    Autorzy: Madeja Zbigniew, Sroka Jolanta
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (3) s.251-260, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The metastatic spread of malignant neoplasms is associated with active migration of cancer cells. The migration of neoplastic cells during the metastatic process may be affected by various extracellular factors, including chemoattractants, haptotactic signals, electric fields, substrate anisotropy, and cell-to-cell contacts. We examined the effect of homotypic collisions and heterotypic interactions with normal human skin fibroblast on the motile activity of Walker carcinosarcoma cells. It was found that Walker carcinosarcoma cells moving in a dense population neither show contact inhibition of movement when colliding with one another nor increase their motile activity as a result of contact stimulation of motility. On the other hand, when plated onto the surface of aligned fibroblasts, Walker carcinosarcoma cells migrated mainly along the long axes of underlying fibroblasts as a result of contact guidance. The directional character of movement (but not the speed of migration) of Walker carcinosarcoma cells on the surface of aligned fibroblasts was completely effaced by RGD-containing synthetic peptide at a concentration of 1 mg/ml but not by 5 ćM verapamil (selective voltage-gated calcium channel inhibitor) or 10 ćM gadolinium chloride (non-specific blocker of mechanosensitive ion channels). The suppression of directional character of migration of tumour cells by RGD-containign peptide was associated with the decrease in the amount of fibronectin macromolecules attached to firbroblasts. This suggests that alignment and anisotropic distribution of fibronectin macromolecules may be responsible for contact guidance of tumour cells moving on the surface of fibroblast.


    665/2523

    Tytuł oryginału: Folia Histochemica et Cytobiologica
    Tytuł polski: Characterization of afferent and efferent galanin-containing nerve fibres in the porcine ovary.
    Autorzy: Majewski Mariusz, Kaleczyc Jerzy, Wąsowicz Krzysztof, Bossowska Agnieszka, Gonkowski Sławomir, Klimaschewski Lars
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (3) s.261-268, il., tab., bibliogr. 42 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • weterynaria

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie angielskie: Double-lebelling immunofluorescence combined with retrograde tracing revealed three subpopulations of galaninimmunoreactive nerve fibres innervating the porcine ovary. The first group originated in ipsilateral dorsal root ganglia Th11-L5 and exhibited colocalization with substance P-, but not with tyrosine-hydroxylase- or dopamine-á-hydroxylase-immunoreactivity. These fibres supplied primordial follicles and large arteries of the ovarian hilus. The second group, arising from the sympathetic inferior mesenteric ganglion, was galanin-immunoreactive, but non-reactive to substance P-, dopamine-á-hydroxylase- or tyrosine-hydroxylase-antisera. Fibres of this type were sparsely distributed in the ovarian cortex. They were observed in connection with small cortical arterioles or in the ovarian cortical stroma. The third group of galanin-containing nerve terminals originated from postganglionic neurons located in sympathetic chain ganglia Th15-L3 and S1. Most of them contained tyrosine-hydroxylase- and dopamine-á-hydroxylase-immunoreactivity. This subset of galanin-positive nerve fibres was the least frequent and was almost exclusively associated with cortical arterioles. The findings are indicative of an involvement of galanin in autonomic and sensory neuronal functions in the ovaries, possibly control of follicle maturation and blood flow.


    666/2523

    Tytuł oryginału: Effect of exogenous pulmonary surfactant preparations on the structure of pulmonary alveoli in newborn rats.
    Autorzy: Żurawski Jakub, Wąsowicz Marcin, Marszałek Andrzej, Florek Ewa, Biczysko Wiesława
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (3) s.285-295, il., bibliogr. 40 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Treatment of pre-term newborns with exogenous surfactant preparation is a well established part of the therapy for respiratory distress syndrome of the newborns (RDS). Since the introduction of surfactant into clinical practice in 1980, hundreds of studies have been published describing beneficial effects of such treatment. There is only limited number of morphological publications reporting adverse effects of surfactant administration. The aim of the present study is to describe morphological changes in the lung after surfactant administration to healthy newborn rats. Two types of surfactant were used: Exosurf (Glaxo Wellcome, England) and Survanta (Abbott Laboratories, USA). Surfactant preparation were given intratracheally in single dose (bolus) (100 mg of lipids per kg b.w.). Animals from control group received 0.9 p.c. saline in equivalent volume. Lung specimens were taken 15, 20, 25 and 30 minutes after drug administration and evaluated by light and electron microscopy. There was no damage in lungs from the control group. Tissue specimens from the Exosurf group revealed severe pathological changes: foci of atelectasis, frank edema in the parenchyma, focal disruption of air-blood barrier, hemorrhages in many alveoli, surfactant particles in man alveolar capillaries, and strongly activated alveolar macrophages. In this group changes appeared as early as 15 min after surfactant administration and intensity of lung injury increased with time. Also, Survanta administration caused damage to the lung tissue. However, the changes were less intense and appeared later (20 - 25 minutes after Survanta treatment). In conclusion, the presented morphological findings proved that exogenous surfactant administration to healthy rat nevborns caused lung damage. Comparing two different surfactant preparation. Exosurf and Survanta, it was shown that the former one produced stronger and faster damage to lung alveoli than the latter one.


    667/2523

    Tytuł oryginału: Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma.
    Autorzy: Nowicki Michał, Miśkowiak Bogdan
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (3) s.297-303, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Neuroblastoma represents one of the most frequently developing malignant solid tumours in children. At the time of diagnosis, in more than half of the bone marrow. The present study was aimed at immnocytochemical analysis of selected neuropeptide manifestation in metastatic cells of neuroblastoma in bone marrow and at comparing the obtained results with the immunophenotype of parental neuroblastoma cells. The studies were performed on bone marrow material obtained from children treated at the Department of Paediatric Haematology and Oncology, University of Medical Sciences, Poznań, Poland, in 1998-2000. Immunocytochemical analysis of nervous tissue markers (employing the immunomax technique) involved 36 bone marrow preparations obtained from 27 children. The analysis included espression of neuron-specific enolase (NSE), PGP 9.5 protein, substance P (SP), chromogranin A (ChA), bombesin (B), galanin (G), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP). Close to 90 p.c. metastatic cells in bone marrow were found to exhibit NSE+SP+B+ phenotype and over a half of the cells manifested additionally expression of PGP 9.5+ChA+NPY+. Comparison of the obtained results with the immunophenotype of neuroblastoma cells obtained directly from the primary tumour demonstrated high correlationof NSE, SP and PGP 9.5 expression. Due to the relative ease of obtaining the bone marrow material and absence of neuromarkers in boen marrow metastatic cells in solid tumors other than neuroblastoma, determination of immunophenotype of the cells may represent a valuable supplementation in preliminary diagnosis of this tumour in children.


    668/2523

    Tytuł oryginału: Expression of class III á-tubulin in neuroendocrine tumours of gastrointestinal tract.
    Autorzy: Jirasek Tomas, Mandys Vaclav, Viklicky Vladimir
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (3) s.305-309, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Class III á-tubulin is regarded as a specific marker for the cells of neuronal origin as well as for the tumours originating from these cells. Its expression is considered one of the earliest events that appear in the cells revealing neuronal differentiation. Using monoclonal antibody TU-20 in an immunohistochemical analysis, we studied the expression of class III á-tubulin in gastrointestinal carcinoid tumours. Paraffin-embedded, formalin-fixed tissue sections from 49 tumour samples obtained from following locations: stomach (4 cases), small intestine (8 cases), appendix (18 cases), rectum (3 cases), pancreas (5 cases), liver metastases (7 cases) and lymph node metastases (4 cases) were used in the study. In 41 of the 49 tumour samples (83.7 p.c.), positive staining for class III á-tubulin was detected, while 8 tumour samples (16.3 p.c.) were negative. Expression of class III á-tubulin was prominent in all three rectal carcinoids and in three atypical caracinoids located in small intestine. Pancreatic neuroendocrine tumours revealed either weak immunostaining (2 cases), or were negative for this marker (3 cases). The intensity of class III á-tubulin immunolabelling was not related to the degree of tumour differentiation. The results of this study suggest that class III á-tubulin could be a perspective marker for gastrointestinal neuroendocrine tumours. Moreover, the differences in its expression could also elucidate some aspects of histogenetic relationships of neuroencodcrine tumours of gastrointestinal tract.


    669/2523

    Tytuł oryginału: Egg yolk platelet proteins from "Xenopus laevis" are amyloidogenic.
    Autorzy: Zemanek Grzegorz, Konieczny Leszek, Piekarska Barbara, Rybarska Janina, Stopa Barbara, Spólnik Paweł, Urbanowicz Barbara, Nowak Mateusz, Król Marcin, Roterman Irena
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (3) s.311-318, il., bibliogr. 39 poz.
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The association of amphibian (Xenopus laevis) egg yolk platelet proteins, represented predominantly by lipovitellin, was studied as a model of the formation of amyloid deposits. Two kinds of molecular organization formed by this protein material - native and heat-denatured - were found to exhibit amyloid properties, although they differ significantly in structural organization. The first consisted in protein molecules arranged in the natural, physiological, net-like platelet organization, with a tendency to orient uni-directionally. The second was obtained by the gradual removal of Congo red from lipovitellin denatured by heating in an excess of dye. This procedure produced twisted fibrillar organization of molecules typical for amyloids, represented predodminantly by end-to-end associated major polypeptide chains of lipovitallin. Both native and denatured structural forms bind Congo red and produce a green birefringence effect, confirming the near-parallel alignment of the complexed Congo red molecules. However, a dye (1,4-bis(1-amino-4-sulfonaphtyl-2-azo)phenylene) closely related to Congo red but with a very weak self-assembling tendency appeared inactive when the spectral shift was studied in a cross-polarization systsem, indicating in this way that dye supramolecularity is an extra factor which may determine binding to amyloid proteins and specific spectral effects.


    670/2523

    Tytuł oryginału: Determination of the content of desmopressin in pharmaceutical preparations by HPLC and validation of the method.
    Autorzy: Dudkiewicz-Wilczyńska Jadwiga, Snycerski Andrzej, Tautt Jadwiga
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.163-168, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of this study was to apply high performance liquid chromatography to the determination of content of desmopressin in pharmaceutical preparations and validation of the method. The satisfactory results have been obtained using a column Luna C 8.5 ćm, 100 x 4.6 mm and a mobile phase containing 0.067 M phosphate buffer of pH = 7 and acetonitrile in the proportion 83 : 17. It has been shown that the elaborated method shows good precision and accuracy and can be applied to the qualitative and quantitative analysis of pharmaceutical preparations containing desmopressin.


    671/2523

    Tytuł oryginału: Acidimetric titration of medicines being salts of weak acids and determining the end-point based on the iodate(V)-iodide reaction.
    Autorzy: Somogyi Eugeniusz, Piotrowska Joanna
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.169-170, tab., bibliogr. 1 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A sample being a salt of weak acid in a solvent is determined with hydrochloric acid in the presence of iodate, iodide, and starch. The excess acid colours the solution blue.


    672/2523

    Tytuł oryginału: Naproxen ion-selective electrode and its application to pharmaceutical analysis.
    Autorzy: Lenik Joanna, Dumkiewicz Ryszard, Wardak Cecylia, Marczewska Barbara
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.171-176, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: An ion-selective membrane electrode was prepared based on ion-pair complex of naproxen with methyltrioctylammonium. Its basic analytical parameters such as: slope characteristics, measuring range, detection limit, response time were determined. The electrode showed Nernstian response from the 10**-1 to 10**-4 mol 1*-1 concentration range and 5.5 - 8.5 pH range, low limit of detection 5 x 10**-5 mol 1*-1 and short response time -20s. Selectivity was good over a number of organic and inorganic anions. The electrode was applied for the determination of naproxen tablets in aqueous solutions by the calibration curve method and standard addition method.


    673/2523

    Tytuł oryginału: Saline cathartics and adsorptive capacity of activated charcoal for doxycycline.
    Autorzy: Afonne O. J., Orisakwe O. E., Ofuefule S. I., Tsalha S., Obi E., Ilondu N. A., Okorie O.
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.177-179, il., bibliogr. 8 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: The effects of sodium chloride and sodium citrate on the in vitro adsorption of doxycycline to activated charcoal have been studied. Solutions of doxycycline alone and doxycycline with 7.5 mg/ml cathartic solutions were vortex - mixed for 30 s with different quantities of activated charcoal, incubated for 30 min at 37řC and analyzed for free doxycycline spectrophotometrically at 348 nm. Addition of NaCl had a significant (p 0.05) increase while sodium citrate produced a significant (p 0.05) decrease in the adsorption of doxycycline on activated charcoal. In all, the adsorption doxycycline on activated charcoal obeyed quantity - dependent kinetics.


    674/2523

    Tytuł oryginału: Biopharmaceutical assessment of eye drops containing aloe (Aloe arborescens Mill.) and neomycin sulphate.
    Autorzy: Kodym Anna, Grześkowiak Edmund, Partyka Danuta, Marcinkowski Andrzej, Kaczyńska-Dyba Ewelina
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.181-186, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie
  • in vitro

    Streszczenie angielskie: The subject of the studies was eye drops made of aloe, containing the group of aloe chemical substances of anti-inflammatory use and neomycin sulphate. The aim of the studies was to evaluate the permeability of biologically active aloe substances, determined as aloenin, through synthetic lipophilic and hydrophilic membranes in a standard perfussion apparatus and in vitro verification of the transport possibilities of these substances through the isolated cornea of pig's eye. The permeability process of biologically active aloe substances determined as aloenin, through synthetic lipophilic and hydrophilic membranes, was analyzed using the first-order kinetics. Estimated quotas of permeability rate constant show that the investigated chemical compounds of aloe, included in the eye drops, diffused through the applied membranes. The studies of permeability through isolated pig's cornea proved that biologically active aloe substances could not overcome this biological larrier. On the basis of biopharmaceutical studies it can be concluded that the eye drops containing aloe and neomycin sulphate, due to the lack of permeating abilities through the eye cornea, should be particularly useful in the treatment of inflammations and infections of external parts of the eye, such as conjuctiva, eyelid edges, lacrimal sac and cornea.


    675/2523

    Tytuł oryginału: The effect of cryoprotectants on the physical properties of large liposomes containing sodium diclofenac.
    Autorzy: Janicki Stanisław, Jankowski Jacek, Szulc Janina, Woyczikowski Brunon, Sznitowska Małgorzata
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.187-191, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Large liposomes (1-10 ćm) containing sodium diclofenac were prepared and lyophilized using lactose or mannitol (7.5 p.c. in respect to the lipid content) as cryoprotectants. The physical studies of liposomes were performed during 30 days of storage in a dry or resuspended form. Lyophilization of large liposomes and storage in the dry form at 5řC increases their physical stability. Lactose is a cryoprotectant which does not influence changes of properties of liposomes regarding their size, encapsulation efficacy and release rate. Large liposomes lyophilized in the presence of mannitol tend to increase in size and encapsulation efficacy, but the lipid bilayers are stabilized and less permeable to the drug.


    676/2523

    Tytuł oryginału: Mechanism of in vitro release kinetics of flurbiprofen loaded ethylcellulose micropellets.
    Autorzy: Mallick Subrata, Roy Kunal, Chakraborty Atanu, Saha Subhayu
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.193-198, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Flurbiprofen loaded ethylcellulose micropellets with different drug loading were prepared by a quasi-emulsion solvent diffusion technique. Encapsulation parameters of micropellets such as actual drug loading, drug encapsulation efficiency (DEE) and loss of coating polymer (LCP) were determined. Actual drug loading was increased with the increased initial drug loading whereas encapsulation efficiency decreased with the increase of actual drug loading. In vitro drug release profiles of these micropellets were evaluated in distilled water (DW) and also in phosphate buffer solution (PBS) to indicate pH dependency release rates. All the batches of micropellets released about 35-59 p.c. in DW and 89-97 p.c. in PBS during the period of 8 h and the burst effect of about 50-75 p.c. in the first 1.5 h was seen only in PBS. The mechanism of release kinetics was evaluated by fitting the release data to the zero order, first order. Higuchi, Baker-Lonsdale and Peppas equations and also to the differential forms of zero order, first order and Higuchi model. Adequate fitting of release data was found with first order, Higuchi and Peppas models and hence these models were selected for F-test statistics for ascertaining the mechanism of drug release. Higuchi model of drug release in DW an dPBS of all the formulations was ruled out due to its significantly different F-value with other models. Thus, mechanism of release of flurbiprofen from ethylcellulose micropellets may be explained by the diffusional exponent model of Peppas et al. as ascertained by F-test statistics rather than the same, based on some other diffusional models even though they have shown good correlation.


    677/2523

    Tytuł oryginału: Synthesis of 6-substituted 6H-indolo[2,3-b]quinolines as novel cytotoxic agents and topoisomerase II inhibitors.
    Autorzy: Kaczmarek Łukasz, Łuniewski Wojciech, Zagrodzki Bogdan, Godlewska Joanna, Osiadacz Jarosław, Wietrzyk Joanna, Opolski Adam, Peczyńska-Czoch Wanda
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.199-207, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A systematic investigation into the impact of the substituents introduced into the indolo[2,3-b]quinoline system is described. The findings clearly demonstarte that the compounds bearing a methyl group or a longer aliphatic chain at the N-6 position are inactive against prokaryotic and eukaryotic cells. The indroduction of alkyl-amino-alkyl substituent at the N-6 position of indolo[2,3-b]quinoline accounts for the appearance of the antimicrobial and cytotoxic properties. The cytotoxicity against oral epidermoid carcinoma KB(ID50) is in the range from 2.0 to 9.0 ćM, and the antimicrobial activity (MIC) falls between 0.003 and 0.50 mM. The structural relation within 6H-indolo[2,3-b]quinolines, concering their antimicrobial and cytotoxic activity, corresponds well with their ability to bind DNA and to inhibit topoisomerase II activity.


    678/2523

    Tytuł oryginału: Synthesis and anticonvulsant properties of new 1-phenyl and 1-phenyloamino-3-penylpyrrolidine-2,5-dione derivatives.
    Autorzy: Obniska Jolanta, Zejc Alfred, Zagórska Agnieszka
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.209-213, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: A series of N-aryl and N-aminoaryl 3-phenyl pyrrolidine-2,5-diones were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentetrazol seizure threshold (sc Met) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses.


    679/2523

    Tytuł oryginału: Synthesis and antiproliferative activity in vitro of new 3-substituted aminopyrazolo[3,4-b]pyridines.
    Autorzy: Poręba Krystyna, Opolski Adam, Wietrzyk Joanna
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.215-222, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The synthesis of several new 3-substituted aminopyrazolo[3,4-b]pyridines is described. The obtained compounds were tested for their antiproliferative activity in vitro. Two of them: 3-chloroacetylaminopyrazolo[3,4-b]pyridine [II] and 3-(2-bromopropionyl-amino)pyrazolo[3,4-b]pyridine [III] revealed cytotoxic activity against the cells of 5 human tumor cell lines applied. Their ID50 values were in the range of the international activity criterion for synthetic agents (4 ćg/ml). The structures of the products II - XVII were estabilished on the basis of elemental analysis and spectral data (IR, 1H NMR and MS).


    680/2523

    Tytuł oryginału: Synthesis and antimicrobial activity of 3-hydroxyimino-5-methyl-2-hexanone(HIMH) and its dioxime derivative.
    Autorzy: Patil Vishwanath R., Donde Kamini J., Jadhav Sanjeev B., Malve Sheela P.
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.223-225, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A new oxime, 3-hydroximino-5-methyl-2-hexanone (HIMH) has been synthesized by the reaction of 1-pentyl nitrite with 5-methyl-2-hexanone under acidic conditions. The subsequent treatment of HIMH with NH2OH HCL gives 5-methyl-2,3-hexanedione dioxime (H2MHDDO). The structures of these compounds have been confirmed by physicochemical and spectral data. A preliminary screening of thses compounds for biological activity against several microorganisms has indicated that they are selective growth inhibitors of m-tuberculosis, in particular.


    681/2523

    Tytuł oryginału: Flavonoid compounds in the flowers of Abutilon indicum (L.) Sweet (Malvaceae).
    Autorzy: Matławska Irena, Sikorska Maria
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.227-229, bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Seven flavonoid compounds: luteolin, chrysoeriol, luteoin 7-O-á-glucopyranoside, chrysoeriol 7-O-á-glucopyranoside, apigenin 7-O-á-glucopyranoside, quercetin 3-O-á-glucopyranoside, quercetin 3-O-ŕ-rhamnopyranosyl (1 - 6)-á-glucopyranoside, were isolated and identified from the flowers of Abutilon indicum (L.) Sweet (Malvaceae).


    682/2523

    Tytuł oryginału: Evaluation of probucol as suppressor of ceftizoxime induced lipid peroxidation.
    Autorzy: Roy Kunal, Saha Achintya, De Kakali, Sengupta Chandana
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.231-234, tab., bibliogr. 34 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Considering drug induced lipid peroxidation, a possible mediator of drug induced toxicity and exploiting free radical scavenging action of probucol, which is a synthetic antioxidant of therapeutic interest, in vitro effects of the antioxidant on drug induced lipid peroxidation have been studied to explore its possible potential in reducing drug induced toxicity. In the present study, ceftizoxime sodium, a third generation of cephalosporin, has been taken as the representative drug and goat whole blood has been used as the lipid source. The study revealed that probucol could suppress drug induced lipid peroxidation to a significant extent. This provides scope for further study on probucol to evaluate its potential for reducing drug induced toxicity and increasing therapeutic index of drug by possible cotherapy.


    683/2523

    Tytuł oryginału: Synthesis of new derivatives of 3-methyl-8-aryl-7,8-dihydro-6H-imidazo[2,1-c][1,2,4] triazin-4-one.
    Autorzy: Sztanke Krzysztof
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.235-236, tab., bibliogr. 12 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Cyclocondensation of 1-aryl-2-hydrazinoimidazolines with pyruvic acid furnished novel derivatives of imidazo [2,1-c] [1,2,4]triazin-4-one.


    684/2523

    Tytuł oryginału: Disturbed right ventricular ejection pattern as a new Doppler echocardiographic sign of acute pulmonary embolism.
    Autorzy: Kurzyna Marcin, Torbicki Adam, Pruszczyk Piotr, Burakowska Barbara, Fijałkowska Anna, Kober Jarosław, Oniszh Karina, Kuca Paweł, Tomkowski Witold, Burakowski Janusz, Wawrzyńska Liliana
    Źródło: Am. J. Cardiol. 2002: 90 (5) s.507-511, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 304,619

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Transthoracic echokardiography (TTE) is frequently performed in patients with suspected acute pulmonary embolism (APE) to search for right ventricular (RV) pressure overload. We prospectively assessed the diagnostic value on the disturbed RV ejection pattern ("60/60 sign") and compared its diagnostic performances with that of the presence of RV pressure overload, as well as with "McConnell sign" based on RV regional wall motion abnormalities. We assessed 100 consecutive patients with clinical suspicion of APE, including those with previous cardiorespiratory disease. After TTE, all of the patients underwent reference diagnostic tests for APE. The 60/60 sign required RV occeleration time of ó 60 ms in presence of tricuspid insufficiency pressure gradient ó 60 mm Hg. APE was ultimately confirmed in 67 of 100 patients. In 17 of 67 patients, 60/60 sign correctly suggested APE, whereas 2 false-positive results were noted: in pulmonary fibrosis and in acute respiratory distress syndrome following lung resection. McConnell sign was fully specific but was noted in only 13 of 67 patients. Sensitivity and specificity were 81 p.c. and 45 p.c. for "RV-pressure overload" signs, 25 p.c. and 94 p.c. for 60/60 sign, and 19 p.c. and 100 p.c. for McConnell sign. When combined, the 2 latter signs were 94 p.c. specific and 36 p.c. sensitive in diagnosing APE. Thus, RV overload at echocardiography is not specific for APE. The 60/60 and McConnell signs are insensitive, but are reliabe and helpful in bedside diagnosis of APE when direct visualization of the pulmonary arteries is impossible...


    685/2523

    Tytuł oryginału: Intravascular ultrasonic evaluation of the magnitude of stent expansion and the mechanisms of lumen enlargement after direct stenting and after conventional stenting with balloon predilatation.
    Autorzy: Dudek Dariusz, Legutko Jacek, Kałuża Grzegorz L., Żmudka Krzysztof, Dubiel Jacek S.
    Źródło: Am. J. Cardiol. 2002: 90 (6) s.639-641, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 304,619

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Currently, a growing number of stents are deployed in a coronary artery without, a preceding ballon dilation (direct stenting [DS]). The mechanisms of lumen enlargement after conventional stent implantation have been recently studied by intravascular ultrasound (IVUS) and encompass: (1) vessel expansion, (2) axial redistribution of plaque, and (3) plaque compression or embolization. In contrast, the impact of direct stent implantation on the plaque and vessel segment undergoing intervention has not been charcterized. The present study investigates the mechanisms of lumen enlargement after coronary DS.


    686/2523

    Tytuł oryginału: Tissue-specific association of the human tyrosine hydroxylase gene with the nuclear matrix.
    Autorzy: Lenartowski Robert, Goc Anna
    Źródło: Neurosci. Lett. 2002: 330 (2) s.151-154, il., bibliogr. 20 poz.
    Sygnatura GBL: 305,936

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • bydło
  • in vitro

    Streszczenie angielskie: Association of the human tyrosine hydroxylase (TH) gene with the nuclear matrix was studied using bovine matrices from tissues differing in expression of the gene. An in vitro binding assay was performed with fragments encompassing the -2300/+2300 region of the human TH gene. All fragments bound to the nuclear matrix from the adrenal medulla but none bound to that from the liver. A computer search of the sequenced part of the studied region revealed putative matrix attachment regions (S/MAR) - one in the promoter and two in the first intron. The (TCAT)n microsatellite repeat included in one the intronic S/MARs seems to influence the binding potential of the human TH gene to the nuclear matrices.


    687/2523

    Tytuł oryginału: Comparative studies on the occurrence of protozoans, bacteria and fungi in the oral cavity of patients with systemic disorders.
    Autorzy: Chomicz Lidia, Piekarczyk Janusz, Starościak Bohdan, Fiedor Piotr, Piekarczyk Barbara, Szubińska Dorota, Zawadzki Paweł J., Walski Michał
    Źródło: Acta Parasitol. 2002: 47 (2) s.147-153, il., bibliogr. s. 152-153
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • mikrobiologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study was to compare the oral cavity status with the species composition of microorganisms colonizing the mounth of patients with or without systemic diseases. Seventy-seven men and women, 19 to 65-years-old, of four groups: hemodialyzed patients (HD), kidney allograft recipients (Tx), congenitally disordered (Cd) and control (C) patients (without systemic diseases) were examined clinically for the oral cavity status and the microorganisms occurring in the mounth were identified. Swabs and samples taken from dental plaques, pockets and periodontium were used for light and electron microscopical studies as well as for protozoan, bacterial and fungal cultures. Entamoeba gingivalis and Trichomonas tenax were found in the HD, Tx, Cd and C groups (top prevalence 14, 14, 87.5 and 25 p.c. respectively); free-living amoebae (with some features of Acanthamoeba sp.) also occurred in several cases. Staphylococcus aureus bacteria were found in 66 p.c. of Cd patients infected with the protozoans. Numerous fecal bacteria and/or fungi Candida albicans have been observed in 41-51-year-old Cd and HD patients. In all patient groups, it was the 41-51-year-olds who showed the highest prevalence of protozoans, bacteria and fungi. The results indicate that metabolic disabilities favour pathological changes in periodontal tissues and may influence the species composition of mixed protozoan, bacterial and/or fungal infections in various ways, in patients with different systemic diseases.


    688/2523

    Tytuł oryginału: The red fox, Vulpes vulpes L., as a potential resorvoir of zoonotic flukes in the Iberian Peninsula.
    Autorzy: Segovia Juan Matias, Torres Jordi, Miquel Jordi
    Źródło: Acta Parasitol. 2002: 47 (2) s.163-166, il., tab., bibliogr. [21] poz.
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • mikrobiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: A parasitological suvery of 396 red foxes (Vulpes vulpes L.) from the Principat d'Andorra, 34 Spanish provinces and Serra da Malcata (Portugal) was carried out to evaluate the fluke status of this wild canid in the Iberian Peninsula. Special attention was devoted to the epidemiological role of this canid in maintaining the potential zoonotic distomatosis. Four fluke species were detected: adults of Brachylaima sp., Alaria alata, Opisthorchis felineus and Metorchis bilis. Seventeen foxes (4.3 p.c.) were infected by at least one of these digeneans. All flukes with an aquatic life cycle were found mainly (26.9 p.c.) in a delimited zone (called zone A), characterised by high amount surface water, with A. alata being the most prevalent species (19.2 p.c.) . Metorchis bilis is more frequently and widely distributed throughout Iberia than O. felineus. Since both flukes have a very similar life cycle, this might be the result of a distinct distribution pattern of their appropriate snails. This study shows that a relatively large natural focus of potential zoonotic flukes (zone A) is located in central Iberia, near the boundary of Portugal with Spain.


    689/2523

    Tytuł oryginału: PFC modular total knee replacement system - middle term results.
    Tytuł polski: Modularny system do całkowitej aloplastyki stawu kolanowego PFC - wyniki w średnim okresie.
    Autorzy: Janecek M., Bucek P.
    Źródło: Ortop. Traumatol. Rehabil. 2002: 4 (3) s.360-365, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 313,531

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • chirurgia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp. Całkowita aloplastyka stawu kolanowego jest obecnie preferowanym rozwiązaniem w przypdkach ciężkich zmian zwyrodnieniowych, zmian w przebiegu reumatoidalnego zapalenia stawów lub w przypadku pourazowych zmian zwyrodnieniowych. Jest ona wskazana u pacjentów w różnym wieku, z wieloma rodzajami zmian patologicznych. Każdy ze stawów wymaga indywidualnego postępowania. Materiał i metody. Autorzy przeprowadzili badania prospektywne 500 pierwotnych aloplastyk całkowitych stawu kolanowego z użyciem protezy modularnej PFC. W latach 1991-2001 przeprowadzono implantację 350 andoprotez (55 obustronnie) u 295 pacjentów z rozpoznaniem pierwotnych zmian zwyrodnieniowych stawu kolanowego, reumatoidalnego zapalenia stawu kolanowego lub zmianach zwyrodnieniowych kolana pourazowych. Średni wiek w badanej grupie pacjentów wynosił 68,3 lata (2883). Badaniem objęto 201 kobiet i 94 mężczyzn. Średni okres obserwacyjny wynosił 7,8 roku (od 2,2 do 10,4 lat). Krzywą przetrwania protezy skonstruowano w oparciu o liczbę zabiegów rewizyjnych z powodu obluzowań aseptycznych. Wyniki. Zgodnie z Systemem Oceny Klinicznej Towarzystwa Kolana, wyniki bardzo dobre uzyskano w 288 kolanach, dobre w 45, złe w 13 i bardzo złe w 4. Obserwowano tylne zwichnięcie komponenty piszczelowej w 2 przypadkach. U jednego pacjenta konieczne było przeprowadzenie wymiany implantu podczas procedury dwuetapowej z powodu obluzowania septycznego. Wnioski. System całkowitej endoprotezy stawu kolanowego PFC wydaje się być protezą dobrej jakości, pozwalającą na rozwiązanie wszystkich problemów mogących powstać w przypadkach aloplastyk pierwotnych i rewizyjnych. Uzyskano dobre wyniki leczenia i wysoki odsetek wyników satysfakcjonujących pacjentów.

    Streszczenie angielskie: Bacgriund. Total knee replacement, which is now the preferred solution for severe primary osteoarthritis, rheumatoid arthritis or posttraumatic osteoarthritis, is indicated in patients of various ages with various pathological changes and deformities. Every joint requires an individual treatment. Material and method. We performed a prospective study of 500 cemented primary PFC modular total knee replacement implanted from 1991 to 2001, involving 350 prosthesis (55 bilateral) in 295 patients wirh diagnosis of primary osteoarthriris, rheumatoid arthritis or posttraumatic osteoarthritis. The average age of our patients was 68.3 years (range 28-83). The study sample included 201 women and 94 men. The mean follow up was 7.8 years (range 2.2 - 10.4 years). A survivorship curve was constructed based on revision surgery due to aseptic loosening. Results. According to the Knee Society Clinical Rating System, the results were excellent in 288 knees, good in 45 knees, poor in 13 knees and extremely poor in 4 knees. We observer posterior dislocation of the tibial component in 2 cases. In one patient we had to replace in a two-stage procedure because of septic loosening. Conclusions. The PFC total knee system seems to be a prosthesis of good quality, permitting the solution of almost any problem that may arise in both primary and revision cases. We achieved good outcomes and high patient satisfaction.


    690/2523

    Tytuł oryginału: Impact of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric ulcerogenesis in experimental animals and in humans.
    Autorzy: Pawlik Teresa, Konturek Peter C., Konturek Jan W., Konturek Stanisław J., Brzozowski Tomasz, Cześnikiewicz Marta, Płonka Małgorzata, Bielański Władysław, Areny Hany
    Źródło: Eur. J. Pharmacol. 2002: 449 (1/2) s.1-15, il., bibliogr. s. 13-15
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Helicobacter pylori (H. pylori) and nonsteroid anti-flammatory drugs (NSAID) are the most common pathogens in the gastroduodenal mucosa in animals and humans, but their relationship in ulcerogenesis has been little studied. Acording to some authors, H. pylori infections in humans does not act synergistically with NSAID on ulcer healing, therefore, there is no need to eradicate the germ. This notion is supported by the finding that the eradication of H. pylori does not affect NSAID-induced gastropatyhy treated with omeprazole and that H. pylori inferction induced a strong cyclooxygenase-2 expression resulting in excessive biosynthesis of gastroprotective prostaglandins, which should in turn counteract NSAID-induced gastropathy and heal existing ulcer. Other investigators claim that H. pylori infection acts synergistically with NSAID on ulcer development, therefore, H. pylori should be eradicated, particularly at the start of long-term NSAID therapy. Maastricht 2-2000 consensus also recommends eradication prior to NSAID treatment, but this eradication does not appear to accelerate ulcer healing or to prevent the recurrent ulcers in NSAID users. Our studies in almost 6000 dyspeptic patients undergoing upper endoscopy and [13C]-urea breath test (UBT) revealed that about 70 p.c. of these patients are H. pylori (+) and about 30.6 p.c. of these develop gastroduodenal ulcers. Of these ulcers, over 70 p.c. were H. pylori (+) positive, 12 p.c. NSAID (+), 8 p.c. both H. pylori (+) and NSAID (+), while 22 p.c. ulcers were H. pylori (-) and NSAID (-) or "idiopathic" ulcers...


    691/2523

    Tytuł oryginału: Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
    Autorzy: Borowicz Kinga K., Zadrożniak Marek, Świąder Mariusz, Kowalska Aneta, Kleinrok Zdzisław, Czuczwar Stanisław J.
    Źródło: Eur. J. Pharmacol. 2002: 449 (1/2) s.85-90, tab., bibliogr. [30] poz.
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • szczury

    Streszczenie angielskie: A number of neurosteroids exert antiseizure and/or neuroprotective properties. The aim of this study was to evaluate the effect of the neurosteroid alphalone on the protective action of conventional antiepileptics in four seizure test. Alphaxalone (up to 5 mg/kg) did not exert a signifcant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsion in mice. The neuroactive steroid at the dose of 2.5 mg/kg significantly raised the threshold for electroconvulsions in mice. at 2.5 mg/kg, alpaxalone diminished the protective activity of valproate against maximal electroshock and at 2.5 - 5 mg/kg against pentetrazole-induced seizures in mice. However, alphaxalone (2.5 mg/kg) did not affect the protective activity of carbamazepine, diphenylhydantoin, phenobarbital or clonazepam against maximal electroshock and 5 mg/kg did not affect that of phenobarbital, clonazepan and ethosuximide against pentetrazole-induced convulsions. Insignificant results were also obtained in the case of co-administration of alphaxalone with phenobarbital, valproate, clonazepam and carbamazepine against aminophylline-evoked seizures in mice. Also, in the kindling model of epilepsy, combinations of the neuroactive steroid (2.5 mg/kg) with valproate, carbamazepine, phenobarbital, diphenylhydantoin or clonazepam at their subprotective doses did not result in pro- or anticonvulsant activity. Valproate (284 mg/kg; the dose used in combination with alphaxalone) produced sgnificant memory deficits in mice. Alpxaxalone (2.5 mg/kg), valproate...


    692/2523

    Tytuł oryginału: Preconditioning with millimolar concentrations of vitamin C or N-acetylcysteine protects L6 muscle cells insulin-stimulated viability and DNA synthesis under oxidative stress.
    Autorzy: Orzechowski Arkadiusz, Łokociejewska Małgorzata, Muras Patrycja, Hocquette Jean-Francois
    Źródło: Life Sci. 2002: 71 (15) s.1793-1808, il., tab., bibliogr. 54 poz.
    Sygnatura GBL: 304,948

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The effect of reactive oxygen/nitrogen species (ROS/RNS)(hydrogen peroxide - H2O2, superoxide anion radical O2ú- and hydroxyl radical úOH - the reaction products of hypoxanthine/xanthine oxidase system), nitric oxide (NOú from sodium nitroprusside - SNP), and peroxynitrite (ONOO- from 3-morpholinosydonimine - SIN-1) on insulin mitogenic effect was studied in L6 muscle cells after one day pretreatment with/or without antioxidants.ROS/RNS inhibited insulin-induced mitogenicity (DNA synthesis). Insulin (0.1 ćM), however, markedly improved mitogenecity in the muscle cells treated with treated with increased concentrations (0.1, 0.5, 1 mM) of donors of H2O2, Oú2-, úOH, ONOO- and NOú. Cell viability assessed by morphological criteria was also monitored. Massive apoptosis was induced by 1 mM of donors of H2O2 and ONOO-, while NOú additionaly induced necrotic cell death. Taken together, these results have shown that ROS/RNS provide a good explanation for the developing resistance to the growth promoting activity of insulin in myoblasts under conditions of oxidative or nitrosative stress. Cell viability showed that neither donor induced cell death when given below 0.5 mM.In order to confirm the deleterious effects of ROS/RNS prior to the subsequent treatment with ROS/RNS plus insulin one day pretreatment with selected antioxidants (sodium ascorbate - ASC (0.01, 01, 1 mM), or N-acetylcysteine - NAC (0.1, 1, 10 mM) was carried out. Surprisingly, at a low dose (micromolar) antioxidants did not abrogate and even worsened the concentration-dependent effects of ROS/RNS...


    693/2523

    Tytuł oryginału: Long-term results of surgery for early gastric cancer.
    Autorzy: Popiela T., Kulig J., Kołodziejczyk P., Sierzega M.
    Źródło: Br. J. Surg. 2002: 89 (8) s.1035-1042, il., tab., bibliogr. 47 poz.
    Sygnatura GBL: 310,131

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacground: Gastrectomy for early gastric cancer, is widely accepted as an adequate therapeutic method. Recent developments of less invasive procedures require the identification who will benefit from such an approach. Methods: A retrospective study was undertaken of 238 patients with early gastric cancer who underwent gastrectomy from 1977 to 1999. Clinicopathological data relating to survival were evaluated. Results: Analysis of 33 node-positive patients (14 per cent) revealed a tumour diameter greater than 20 mm (P = 0.011), depressed macroscopic type (P 0.05), diffuse histological type (P 0.001), poor tumour differentiation ( P 0.001) and infiltration of the submucosal layer (P 0.002) as factors assopciated with lymph node metastasis. Multivariate analysis found diffuse histological type to be an independent risk factor. The overall 5-year survival rate was 87 p.c., and was significantly better in patients who underwent radical lymphadenectomy than in those who had regional lymph node dissection (92 versus 78 p.c.; P 0.01). Similarly, patients younger than 65 years had a more favourable 5-year survival rate (90 p.c.) than oder ones (77 p.c.). Multivariate analysis with the Cox proportional hazards model confirmed patient age and type of lymphadenectomy as independent prognostic factors. Conclusion: The findings suggest that extended lymph node dissection may be beneficial for some patients with early cancer, althoug randomized clinical trials are needed to evaluate this observation further.


    694/2523

    Tytuł oryginału: Usefulness of endothelin-1 concentration in capillary blood in patients with mitral stenosis as a predictor of regression of pulmonary hypertension after mitral valve replacement or valvuloplasty.
    Autorzy: Snopek Grażyna, Pogorzelska Hanna, Rywik Tomasz M., Browarek Aldona, Janas Jadwiga, Korewicki Jerzy
    Źródło: Am. J. Cardiol. 2002: 90 (2) s.188-189, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 304,619

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.


    695/2523

    Tytuł oryginału: Isolation and characterization of enterohaemorrhagic Escherichia coli O157:H7 from cattle in Belgium and Poland.
    Autorzy: Tutenel A. V., Pierard D., Uradziński J., Jóźwik E., Pastuszczak M., Van Hende J., Uyttendaele M., Debevere J., Cheasty T., Van Hoof J., De Zutter L.
    Źródło: Epidemiol. Infect. 2002: 129 (1) s.41-47, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,292

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • mikrobiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: EHEC 0157 were isolated from faeces of Belgian and Polish beef slaughter cattle. In Belgium, 1281 faecal samples were analysed by immunomagnetic separation [IMS] after enrichment in buffered peptone water from June 1998 till July 1999. Eighty-one samples (6.3 p.c.) were positive for E. coli O157. Phage type 8 was most frequently found. Bulls between 1 and 2 years old., slaughtered in September and October were most frequently found positive. Atypical biochemical features were observed in some isolates: 22 (27 p.c.) isolates were urease positive and 1 (1ú2 p.c.) isolate was unable to ferment lactose. In Poland, 551 faecal samples, taken from January 1999 till December 1999, were examined using exactly the same techniques. Four faecal samples (0ú7 p.c.) were positive for 0157 EHEC, yielding seven phage type 8 isolates. All positive samples were from cattle younger than 2 years. Positive samples occurred in August, September and October.


    696/2523

    Tytuł oryginału: Novijj oksidaznijj metod viznachenija vmistu L-laktatu.
    Tytuł angielski: A new oxidase-coupled colorimetric method for L-lactate assay.
    Autorzy: Pavlishko G. M., Majjdan M. M., Sibirnijj A. A., Gonchar M. V.
    Źródło: Ukr. Biokhim. Zh. 2002: 74 (2) s.134-139, il., tab., bibliogr. 9 poz., sum.

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: A new oxidase-coupled colorimetric method for analysis of L-lactate in biological fluids has been developed withous use of peroxidase. The methods is based on lactate oxidase-catalysed transformation lactate to pyruvate which is determined photometroically in the next dye-produing reaction of 3-methyl-2-benzothiazolinone hydrazone (MBTH) in the presence of ferric ions. Sensivity of the method is estimated as 0.1 micromole of analyte in 4-ml of reaction mixture. Linearity is observed in the range 0.1 - 1.0 micromole of L-lactate in sample (r = 0.99943; p 0.0001). The developed method has been adapted for assay of L=lactic acid in kefirs and yogurts.


    697/2523

    Tytuł oryginału: Improved reperfusion and clinical outcome with enoxaparin as an adjunct to streptokinase thrombolysis in acute myocardial infarction.
    Autorzy: Simoons M. L., Krzemińska-Pakuła M., Alonso A., Goodman S. G., Kali A., Loos U., Gosset F., Louer V., Bigonzi F.
    Źródło: Eur. Heart J. 2002: 23 (16) s.1282-1290, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 306,213

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Aims. To establish whether the addition of enoxaparin (a low-molecular-weight heparin0 to streptokinase therapy improves early and sustained patency and clinical outcome in patients with evolving myocardial infarction. Methods and results. A total of 496 patients with acute myocardial infarction treated with streptokinase were randomized to an intravenous bolus (30 mg) and subcutaneous injections (1 mgúkg-1 twice daily) of enoxaparin (n = 253), or placebo (n = 243) for 3-8 days. The median duration of treatment in both groups was 5 days. ST-segment resolution at 90 min and 180 min measured by electrocardiogram was improved in patients receiving enoxaparin. Complete, partial and no ST-segment resolution at 180 min was observed in 36 p.c., 44 p.c. and 19 p.c. in the enoxaparin group vs 25 p.c., 44 p.c. and 31 p.c. in the placebo group, rspectively (P = 0.004). Assessment of the primary end-point revealed improved TIMI-3 flow with enoxaparin vs placebo (70 p.c. vs 58 p.c., P = 0ú01). Combined TIMI-2 and -3 flow was also improved (88 p.c. vs 72 p.c., P = 0ú001), as was TIMI frame count (P = 0ú003). The triple clinical end-point of death, reinfarction and recurrent angina at 30 days was reduced with enoxaparin (13 p.c. vs 21 p.c., P = 0.03). Conclusion. Streptokinase in combination with enoxaparin is associated with better ST-segment resolution and better angiographic patency at days 5-10, suggesting more effective reperfusion. This was associated with a significant reduction in clinical events, indicating less reocclusion.


    698/2523

    Tytuł oryginału: Influence of agents affecting voltage-dependent calcium channels and dantrolene on the anticonvulsant action of the AMPA/kainate receptor antagonist LY 300164 in mice.
    Autorzy: Świąder Mariusz, Borowicz Kinga K., Porębiak Jacek, Kleinrok Zdzisław, Czuczwar Stanisław J.
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (4) s.311-319, il., tab., bibliogr. s. 317-319
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: It was previously documented that calcium (Caý+) channel inhibitors intensified the protective effects of conventional antiepileptics against electroconvulsions in mice. The aim of this study was to evaluate the effects of Caý+ channel inhibitors (nifedipine, nicardipine and fluarizine) on the anticonvulsant action of the new AMPA/kainate receptor antagonist, 7-acetyl-3-94-aminophenyl)-8,9-dihydro-8-methyl-7H--1,3-dioxazolo[4,5-h][2,3]-benzodiazepine (LY 300164), against maximal electroshock (MES)-induced seizures in mice. Dantrolene (an inhibitor of Caý+ release from intracellular stroes) was also included. Nifedipine (30 mg/kg) and flunarizine (15 mg/kg) raised the threshold for electroconvulsions, being ineffective at lower dose. Nicardipine (up to 30 mg/kg) and dantrolene (up to 20 mg/kg) did not affect this parameter. Flunarizine (10 mg/kg), nicardipine (20 mg/kg) and dantrolene (20 mg/kg) potentiated the efficacy of LY 300164 against MES. However, nicardipine (at 20 mg/kg) raised the free plasma concentraion of LY 300164. Nifedipine (30 mg/kg), given even in a dose raising the electroconvulsive threshold, did not significantly alter the protective effect of LY 300164 against MES. Furthermore, the Caý+ channel agonist - BY k-8644 (at mg/kg) did not influence the protection offered by LY 300164 against MES. Finally, this Caý+ channel activator did not affect the enhanced efficacy of LY 300164 by Caý+ channel modulators. The only exception was the combination of LY 300164 with flunarizine. Combined treatment with LY 300164 and dantrolene (20 mg/kg)...


    699/2523

    Tytuł oryginału: Molsidomine potentiates the protective activity of GYKI 52466, a non-NMDA antagonist, MK-801, a non-competitive NMDA antagonist, and riluzole against electroconvulsions in mice.
    Autorzy: Tutka Piotr, Olszewski Krzysztof, Woźniak Małgorzata, Kleinrok Zdzisław, Czuczwar Stanisław J., Wielosz Marian
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (4) s.321-326, tab., bibliogr. [35] poz.
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: The influence of molsidomine, a donor of nitric oxide (NO), L-arginine, a substrate for NO synthesis, and NG-nitro-L-arginine (NNA), an inhibitor of NO synthase, on the protective activity of CGP 40116, GYKI 52466, MK-801, and riluzole against electroconvulsions was studied in mice. Molsidomine (100 mg kg-1; i.p.) potentiated the protective activity of GYKI 52466, MK-801, and riluzole but did not influence the protection offered by CGP 40116. In contrast to molsidomine, L-arginine (500 mg kg-1, i.p.) did not impair the protective activity of any anticonvulsant. In a dose of 40 mg kg-1, NNA administered i.p. did not afect the protection offered by any excitatory amino acid antagonists and riluzole. Combinations of molsidomine with either GYKI 52466 or MK-801 as well as riluzole did not cause a memory deficit in the passive avoidance task. However, the combined treatment of molsidomine with these anticonvulsant resulted in a motor impairment quantified by the chimney test. The lack of effect of L-arginine and NNA on the protective activity of excitatory amino acid antagonist suggests that molsidomine-evoked alterations in the protection provided by some excitatory amino acid antagonists against electroconvulsions are independent of the NO pathway.


    700/2523

    Tytuł oryginału: Differential effects of repeated imipramine on hippocampal responsiveness to adenosine and serotonin.
    Autorzy: Zahorodna Agnieszka, Bijak Maria, Hess Grzegorz
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (4) s.355-360, il., bibliogr. [23] poz.
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Imipramine-induced enhacement of the inhibitory action of 5-HT1A receptor activation in hippocampal pyramidal neurons has been attributed to alterations in the transduction mechanism that involves G protein-dependent opening of K+ channels. Postsynaptic 5-HT1A and adenosine A1 receptors may share that transduction pathway. We investigated the influence of repeated imipramine administration on 5-ht1A and adenosine A1 receptor-mediated effects in rat hippocampal slices. Repeated imipramine selectively enhanced the postsynaptic effects of 5-HT1A receptor activation hyperpolarization and reduction of input resistance of neurons and reduction of the population spike amplitude. In contrast, after imipramine treatment only the presynaptic effect of adenosine receptor agonist, a decrease of the field excitatory postsynaptic potential, was enhanced. The data demonstrate that alterations in the presumed common transduction mechanism that was postulated for the 5-HT1A and adenosine A1 receptor-mediated activation of K+ channels are not involved in the effect of repeated imipramine administration.


    701/2523

    Tytuł oryginału: Comparison of the Ames test and a newly developed assay for detection of mutagenic pollution of marine environments.
    Autorzy: Czyż Agata, Szpilewska Hanna, Dutkiewicz Rafał, Kowalska Wioletta, Biniewska-Godlewska Anna, Węgrzyn Grzegorz
    Źródło: Mutat. Res 2002: 519 (1/2) s.67-74, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 304,952

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska
  • genetyka

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: A new assay for detection of mutagenic pollution of marine environments, based on the use of a series of genetically modified Vibrio harvbeyi strains, was developed recently. Here, we compared this assay with a commonly used Ames test, employing mutants of Salmonella enterica serovar Typhimurium. We found that survival of S. enterica serovar Typhimurium inartificial marine water and in different samples of marine water is dramatically reduced relative to that of V. harveyi strains. This indicates that V. harveyi strains are significantly more useful in testing samples of marine water. Moreover, sensitivity of both assays was compared. We found that using the V. harveyi assay it is possible to detect significantly (from a few to several times) lower concentrations of typical chemical mutagents than employing the Ames test. Although the higher sensitivity of the V. harveyi test relative to the Ames assay may be of minor importance when testing mutagenicity of certain chemicals in their pure from under laboratory conditions, this feature is very important in testing samples of marine water. Therefore, we assume that the V. harveyi assay may be an adequate test for detection of mutagenic pollution of marine environments.


    702/2523

    Tytuł oryginału: Prof. dr hab. Zygmunt Albert, 30.10.1908 - 07.10.2001.
    Autorzy: Jeleń Michał
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.3-4
    Sygnatura GBL: 301,852

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca biograficzna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Albert
  • Zygmunt 1908-2001


    703/2523

    Tytuł oryginału: Prof. dr hab. Daniel Chibowski, 29.10.1932 - 04.08.2001.
    Autorzy: Korobowicz Elżbieta
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.5-6
    Sygnatura GBL: 301,852

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca biograficzna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Chibowski
  • Daniel 1932-2001


    704/2523

    Tytuł oryginału: Bovine spongiform encephalopathy update.
    Autorzy: Bradley Ray
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.7-16, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • koty
  • bydło

    Streszczenie angielskie: Bovine spongiform encephalopathy (BSE) is a zoonosis being the origin of variant Creutzefeldt-Jacob disease and an important cattle disease in its own right. Countries have been show to learn the importance of protecting, not only their cattle populations, but also their human populations. Since 2000, several additional European countries have reported BSE in native-born stock and this has led to a concern about the BSE status of countries that have imported cattle and cattle products from infected countries. Extensive feed and offal bans and application of newly-developed, "Rapid" tests for prion protein in central nervous tissue of targed, high-risk animals and slaughter cattle over 30 months old now provides the tools whereby the public are fully protected and BSE can be eradicated.


    705/2523

    Tytuł oryginału: Prognostic significance of CD44v6 and nm23 protein immunoexpression in laryngeal squamous cell carcinoma.
    Autorzy: Sikorska Beata, Danilewicz Marian, Wągrowska-Danilewicz Małgorzata
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.17-24, il., bibliogr. 34 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In several tumours expression of CD44 and nm23 protein has been linked to tumour progression and metastasis. The aim of this study was to determine if there is any relationship between CD44v6 and nm23 protein immunoreactivity in squamous cancer cells and prognosis in patients with laryngeal carcinoma. The samples of human larynx cancer from patients with lymph node metastases and without lymph node involvement were analysed for CD44v6 and nm23 protein expression by immunohistochemistry using monoclonal antibodies. There was no significant difference in CD44v6 immunoexpression in cancer cells in patients with and without metastases. The statistical analysis did not reveal difference in survival time between patients with high and low CD44v6 immunoreactivity. The expression of nm23 protein in laryngeal cancer in patients with lymphe node metastases was significantly decreased in comparison with patients without metastases. Analysis of survival revealed that patients with lower expression of nm23 protein in tumour tissue had significantly shorter survival than patients with higher nm23 immunoreactivity. The results suggest that nm23 protein immunoreactivity can be useful in predicting tumour behviour in laryngeal cancer patients and indicate a lack of association between CD44v6 immunoexpression and tumour progression in those patients.


    706/2523

    Tytuł oryginału: Prognostic significance of selected immunohistochemical parameters in patients with invasive breast carcinoma concomitant with ductal carcinoma in situ.
    Autorzy: Patla Anna, Rudnicka-Sosin Lucyna, Pawlęga Janusz, Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.25-27, tab., bibliogr. 19 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The purpose of the present study was to carry out multivariate analysis of the effect of the expression of estrogen and progesterone receptors, p53, proliferative antigen (ki67) and c-erbB-2 on 5-year survival in patients with invasive breast carcinoma concomitant with duxtal carcinoma in situ. Material study consisted of tissue specimens obtained from 48 patients undergoing modified Patey's mastectomy between 1991 and 1998. Univariate analysis rervealed that the variables significantly affecting survival were tumour size on gross examination and the level of estrogen and progesterone receptors in the cells of invasive ductal carcinoma of the breast (for the level of significance p = 0.05). The Cox regression a significant effect on survival was the level of estrogen receptors in invasive cancer cells.


    707/2523

    Tytuł oryginału: Synchronous serrated adenoma of the appendix and high-grade ovarian carcinoma: a case demonstrating different origin of the two neoplasms.
    Autorzy: Rudzki Zbigniew, Zazula Monika, Białas Magdalena, Klimek Marek, Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.29-34, il., bibliogr. 12 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Association of mucinous adenomas of the appendix and mucinous ovarian tumors is well known. The origin of the ovarian tumor (metastases from the appendix vs independent primary) is still debated. Serrated adenoma is a rare neoplasm of the distal gastrointestinal tract, and its precancerous role in the colorectum was recently postulated. A 74-year-old patient was subjected to hysterectomy with routine appendectomy due to a 17-cm tumor of her right ovary. Histological examination revealed a high-grade ovarian adenocarcinoma with peritoneal involvement. The appendix, grossly unremarkable, harbored a serrated adenoma with no evidence of invasion or malignant transformation. Immunohistochemical examination revealed CD7+, CK20-phenotype of the ovarian and reverse (CK7-, CK20+) phenotype of the appendiceal tumor. Microsatelite analysis demonstrated microsatellite instability (MSI-high) within the serrated adenoma (4/5 markers with positive amplification) and no MSI (0/6 amplified markers) in the samples from the ovarian carcinoma, its metastases and the univolved uterine cervix. There were also differences in LOH pattern between the ovarian adenocarcinoma and the serrated adenoma. The findings suggest two independent primaries with profound differences in tumorigenetic pathways of both lesions. To the best of our knowledge this the first report of synchronous serrated adenoma of the appendix and ovarian carcinoma.


    708/2523

    Tytuł oryginału: Fatal post-transplant lymphoproliferative disorder following allogeneic bone marrow transplantation for aplastic anemia.
    Autorzy: Rudzki Zbigniew, Werda Larissa, Piątkowska-Jakubas Beata, Mensah Patrycja, Zazula Monika, Białas Magdalena, Skotnicki Aleksander B., Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.35-40, il., bibliogr. 13 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • hematologia
  • transplantologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Post-transplant lymphoproliferative disorder (PTLD) constitutes serious complication of allogeneic bone marrow transplantation. We describe a case of PTLD in a twenty-six-old male treated with bone marrow transplantation for aplastic anemia of unknown case. The patient received unmanipulated marrow graft from his HLA-matched brother. Fifty-one days post transplant he developed progressive enlargement of cervical lymph nodes, followed by hepatosplenomegaly and generalized lymphadenopathy. Polymorphic PTLD was diagnosed basing on the lymph node histopathology, positive EBV detection, flow cytometry and IgH rearrangenement studies proving monoclonality (capillary electrophoresis with ABI PRISM 310 genetic Analyzer). There was no response to anti- CD20 antibody, cessation of immunosuppression, donor lymphocyte infusion and cystatic therapy. The patient died on the 65th day of multiple organ failure. We discuss the diagnostics and management of PTLD in the setting of bone marrow transplantation.


    709/2523

    Tytuł oryginału: Characteristics of Candida albicans strains isolated from the oral cavity in HIV-positive patients.
    Tytuł polski: Charakterystyka szczepów Candida albicans wyizolowanych z jamy ustnej pacjentów HIV-dodatnich.
    Autorzy: Macura Anna B., Bort Artur
    Źródło: Mikol. Lek. 2002: 9 (1) s.17-25, il., tab., bibliogr. 14 poz., sum.
    Sygnatura GBL: 313,181

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • aIDS

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Badaniem objęto 35 szczepów C. albicans wyizolowanych obficie z jamy ustnej pacjentów HIV-dodatnich oraz 15 szczepów C. albicans izolowanych od osób zdrowych HIV-ujemnych. Do oceny aktywności enzymatycznej użyto testu API ZYM firmy bioM‚rieux, ocenę wrażliwości na leki przeciwgrzybicze przeprowadzono przy użyciu testu TAB Fungus oraz metody dyfuzujno-krążkowej. Genotypowanie szczepów C. albicans wykonano techniką PCR - fingerprinting. W tym badaniu uwzględniono 24 szczepy C. albicans pochodzące z obfitego wzrostu od pacjentów HIV+ i 11 szczepów C. albicans z grupy porównawczej. (HIV-ujemnych). W badaniu nie stwierdzono istotnych różnic między szczepami pochodzącymi od pacjentów zarażonych HIV i zdrowych pod względem aktywności enzymatycznej i wrażliwości na antymiotyki. W obydwu grupach najczęściej występowały szczepy o biotypach L i M, przy czym w grupie pacjentów HIV+ istnała zależność między biotypem M i występowaniem objawów klinicznych grzybicy. Opisano nowy biotyp S u 4 szczepów. Analiza genotypów C. albicans wykazała zróżnicowanie genetyczne wśród szczepów wyizolowanych w obu grupach.

    Streszczenie angielskie: The study was carried out on 35 C. albicans strains isolated from an abudant growth in the oral cavity of HIV+ patients and on 15 strains isolated from HIV negative healthy volunteers. Enzymatic activity was evaluated by using API ZYM test, manufactured by bioM‚rieux, drug susceptibility was tested by using both ATB Fungus test and disk-diffusion method. Genotyping of the C. albicans strains was performed by using PCR fingeprinting. Twenty four C. albicans strains were isolated from abundant growth in HIV+ patients while 11 C. albicans strains originated from the control group (HIV-). No significant differences were found between the strains originating from HIV+ patients and healthy persons as regards enzymatic activity and drug susceptibility. The L and M biotype strains were frequent in both of the groups. There was a relationship between M biotype and the presence of clinical manifestations of mycosis in the HIV+ group. A new biotype was detected in four strains; it was described as S biotype. The analysis of genotypes revealed a genetic variability of C. albicans genotypes isolated in both of the group.


    710/2523

    Tytuł oryginału: Cyproterone, norethindrone, medroxyprogesterone and levonorgestrel are less potent local human growth hormone and insulin-like growth factor I secretion stimulators than progesterone in human breast cancer explants expressing the estrogen receptor.
    Autorzy: Milewicz T., Kołodziejczyk J., Krzysiek J., Basta A., Sztefko K., Kurek S., Stachura J., Gregoraszczuk E. L.
    Źródło: Gynecol. Endocrinol. 2002: 16 (4) s.319-329, il., bibliogr. 57 poz.
    Sygnatura GBL: 313,072

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The aim of the present study was to compare the ability of natural progesterone and synthetic progestins to stimulate local growth hormone (GH) and insulin-like growth factor I (IGF-I) secretion by breast cancer explants. Explants obtained during surgery were divided according to their estrogen/progesterone receptor phenotype - ER(+)PR(-); ER(+)PR(+); ER(-)PR(+) - as determined by immunocytochemistry. Natural progesterone (10**-5 mol/l) and synthetic progestins (cyproterone acetate (5 x 10**-7 mol/l), norethindrone (10**-5 mol/l), medroxyprogesterone acetate (10**-7 mol/l), and levonorgestrel (10**-7 mol/l) were tested in vitro for their ability to induce secretion of proliferation-promoting agents such as human GH (hGH) and IGF-I. All hormone-dependent breast cancer cell types responded to progesterone stimulation with increased local hGH secretion, while in the non-malignant tissue this effect was observed only in PR(+) cells. Moreover, progesterone in only PR(+) cells in vitro stimulated local IGF-I secretion by both malignant and non-malignant tissue. Medroxyprogesterone and levonorgestrel increased GH secretion by both malignant and non-malignant ER(-)PR(+) breast cancer explants, while cypropterone stimulated it only in non-malignant tissue. None of the synthetic progestins tested in this experiment exerted an effect on GH secretion by both malignant and non-malignant tissue of ER(+) breast cancer explants. The present data additionally showed that, apart from cyproterone, which increased IGF-1 secretion in the same manner as progesterone by both malignant and non-malignant ER(-)PR(+) breast explants...


    711/2523

    Tytuł oryginału: Turner's syndrome followed by acromegaly in the third decade of life: an unusual coincidence of two rare conditions.
    Autorzy: Bolanowski B., Łomna-Bogdanov E., Kosmala W., Malczewska J., Ślęzak R., Zadrożna B., Podgórski J. K.
    Źródło: Gynecol. Endocrinol. 2002: 16 (4) s.331-334, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,072

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: We present an unusual coincidence of acromegaly and Turner's syndrome. A girl was diagnosed with Turner's syndrome when she presented with short stature, primary amenorrhea, Hashimoto's thyroiditis, and some heart and renal anomalies. No therapy with growth hormone and only a few months treatment with estrogen-progestin was given. A typical picture of acromegaly occurred in the third decade of her life. Bone radiographs and densitometry suggested the more pronounced influence of acromegaly within the skeleton, but no features typical for acromegaly were found in the cardiovascular system. To our knowledge no case of coincidence of the above mentioned conditions has been reported to date. The influence of both of these conditions on bones and heart is discussed.


    712/2523

    Tytuł oryginału: Axial length measurements after cataract surgery in adults.
    Autorzy: Lesiewska-Junk Hanna, Malukiewicz-Wiśniewska Grażyna
    Źródło: Ophthalmologica 2002: 216 (4) s.239-241, tab., bibliogr. 8 poz.
    Sygnatura GBL: 300,913

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • okulistyka

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: The purpose of the study was to check the difference in eye axial lenght before and after cataract surgery and to find out of possible correlation with refraction changes. The axial lenght was measured by ultrasound before and after cataract extraction with intraocular lens implantation. Keratomery measurements were also performed. The study comprised 32 eye. The mean difference in axial lenght was 0.53 mm. The mean difference in keratomery was 0.37 D. There was no correlation between these values. Conclusion: The change in axial length are not due to corneal curve changes. Perhaps in pseudophakic eyes different ultrasound velocity should be used.


    713/2523

    Tytuł oryginału: Are ultra-slow isoperiodic oscillations in rat intergeniculate leaflet neurons dependent on reciprocal connection with its contralaterally located counterpart?
    Autorzy: Lewandowski Marian H., Błasiak Tomasz, Błasiak Anna
    Źródło: Neurosci. Lett. 2002: 330 (3) s.243-246, il., bibliogr. 13 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: We investigated effects of the electrical lesion and/or chemical inactivation of intergeniculate leaflet (IGL) neurons on the ultra-slow isoperiodic neuronal oscillation of the contralaterally located IGL. The spontaneous extracellular activity of neurons, recorded simultaneously in both leaflets of the lateral geniculate nucleus, showed an ultradian oscillatory patern. In all our experiments, both the electrical lesion and the inactivation of neurons via the blockade of action potential generation did not cause any changes in the neuronal activity pattern in the contralaterally located geniculate leaflet. The obtained results show that a bilateral IGL connection is not necessary for the pattern of neuronal oscillation in the IGL. Hence the functional significance of a reciprocal connection between both lateral geniculate nucleus leaflets is still an open question.


    714/2523

    Tytuł oryginału: Ligands of the peroxisome proliferator-activated receptor-PPAR-ŕ reduce myocardial infarct size.
    Autorzy: Wayman Nicole S., Ellis Bilinda L., Thiemermann Christoph
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR243-BR247, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: This study was desibned to investigate the effects of two, chemically distinct activators of PPAR-ŕ (clofibrate and WY14643) in a rat model of acute myocardial infaction. Material/Methods: Male Wistar rats were anesthetized with sodium thiopentone (120 mg/kg i.v.) and subjected to regional myocardial ischemia (for 25 min) and reperfusion (for 2 h). Area at risk was determined by injection of Evans Blue dye and infarct size after staining with nitroblue tetrazolium. Results: Pre-treatment of rats with the PPAR-ŕ agonists clofibrate (0.3 mg/kg) caused a significant reduction inmyocardial infarct size of 43 p.c. Similarly, pre-treatment of rats with the PPAR-ŕ agonists WY14643 (1 mg/kg) caused a significant reduction inmyocardial infarct size of 43 p.c. Conclusions: Taken together, these results show that ligands of PPAR-ŕ reduce the tissue necrosis associated with acute myocardial infarction. We propose that fibrates and other PPAR-ŕ agonists may be useful in conditions associated with ischemia-reperfusion of the heart and other organs.


    715/2523

    Tytuł oryginału: Biochemical characterization of the arginine degrading enzymes arginase and arginine deiminase and their effect on nitric oxide production.
    Autorzy: Dillon Brian J., Holtsberg Frederick W., Ensor C. Mark, Bomalaski John S., Clark Mike A.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR248-BR253, il., tab., bibliogr. 47 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Background: Nitric oxide (NO) is a biomediator believed to be synthesized primarily from extracellular arginine. Various methodologies have been used to inhibit NO synthesis so as to elucidate its physiological and pathophysiological functions. Several investigators have utilized various arginine degrading enzymes as a means of lowering extracellular arginine. Arginase, most commonly derived from mammalian sources, has been most often used. However, arginase has failed to inhibit NO synthesis. Herefore, a systematic biochemical characterization of arginase and arginine deiminase (ADI) derived from M. Hominus was undertaken. Material/Methods: The murine macrophage cell line N-9 was treated with either arginase or arginine deiminase to determine the effect on intracellular and extracellular arginine and nitric oxide production. Results: Arginase was found to have an alkaline pH optima (~9.5) with little enzyme activity at physiological pH. In contrast, the pH optima of ADI was ~6.5, retaining 70 p.c. of its activity at physiological pH. ADI had more than 1000 fold higher affinity for arginine (Km ~30 ćM for ADI vs ~45 mM for arginase), and was able to lower arginine levels to a much greater extent than arginase. ADI, unlike arginase, was effective in lowering extracelluar arginine in tissue culture media and inhibit NO production by the murine macrophage cell line N-9 in response to gamma interferon and LPS stimulation. Conclusions: These data suggest that ADI may be useful for delineating the role of NO in a variety of biological systems as well as determining the role of extracellular arginine in its synthesis.


    716/2523

    Tytuł oryginału: Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives.
    Autorzy: Chowdhury Arnab Roy, Mandal Suparna, Mittra Bidyottam, Sharma Shalini, Mukhopadhyay Sibabrata, Majumder Hemanta K.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR254-BR260, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Background: Betulinic acid, a naturally abundant, plant derived, pentacyclic triterpenoid possesses anti-HIV, anti-malarial and anti-inflammatory properties and has recently emerged as a potent anti-tumor compound. This study explores the mode of action of betulinic acid on eukaryotic topoisomerase I and identifies the major functional group responsible along with more potent derivatives. Material/Methods: Topoisomerase I relaxation activity was electrophoretically measured by the decreased mobility of the relaxed monomers followed by ethidium bromide staining. DNA cleavage was studied by electrophoretic separation of the nicked monomers from the relaxed and supercoiled monomers in presence of ethidium bromide. In-vivo DNA cleavage was studied in blasted mouse splenocytes by the SDS-K+ trapping of 3H-DNA-topoisomerase I-camptothecin ternary complex. Results: Betulinic acid exerts its inhibitory effect by preventing topoisomerase I-DNA interaction as a result of which the 'cleavable complex' is not formed. In consequence, it also acts as an antagonist to camptothecin-mediated cleavage. A series of analogues modified at C-3, C-17 and C-20 positions of betulinic acid were subsequently assayed for inhibition of topoisomerase I catalytic activity. Replacemnt of the 17-carboxylic group reduces the inhibitory effect and decarboxylation leads to the complete loss of inhibitory effect. Conclusion: This study is the first detail report of betulinic acid as a very potent inhibitior of eukaryotic topoisomerase I and highlights the necessity of the carboxylic functional group. Dihydro betulinic acid is the most potent (IC50 = 0.5 ćM) pentacyclic triterpenoid to inhibit eukaryotic topoisomerase I till date and can be exploited as a strong candidate for anti-tumor drug designing.


    717/2523

    Tytuł oryginału: Biophysical characterization of albumin preparations from blood serum of healthy donors and patients with renal diseases. P. 1: Spectrofluorometric analysis.
    Autorzy: Parkhomenko Tatiana V., Klicenko Oksana A., Shavlovski Mikhail M., Kuznetsova Irina M., Uversky Vladimir N., Turoverov Konstantin K.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR261-BR265, il., bibliogr. 35 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: Serum albumin (SA) is a major proteinacous component of the blood plasma. In the present study we report on the determination and structural characterization of the modified SA in the plasma of glomeruklonephritis (GN) patients. Fluorescence analysis of albumin-enriched fractions (AEF) isolated from serum of GN patients leads to the discovery of a proteinacous component with essential blue shift of intrinsic fluorescence. Material/Methods: AEF were isolated from serum blood of 35 GN patietns, 30 GN patietns with chronic renal failure (CRF) corrected by hemodialysis (HD) and 40 healthy donors. Their fluorescence chacteristics have been compared using variations in teh value of parameter A = I320/I365 that characterizes fluorescence spectrum position and shape. Results: The fluorescence spectra of AEF from GN and GN with CRF patient were blue-and red-shifted, respectively, in comparison with spectra of donors' serum. The value of parameter A was 1.27 ń 0.05 for protein preparateions from healthy donors, while this characteristic lies within range of 1.3-2.1 or 0.77 - 1.29 for Gn and Gn with CRF patients, resectively. Moreover, for GN patients, the magnitude of spectral parameter A was approaching control values during the treatment of disease. Conclusion: hSA enriched fractions isolated from GN patients or GN patients with CRF corrected by HD differ by their spectrofluorometric properties from those of healthy donors. This technique allows the detection of renal disease and the efficiency fo thier cure.


    718/2523

    Tytuł oryginału: Biophysical characterization of albumin preparations from blood serum of healthy donors and patients with renal diseases. P. 2: Evidence for the enhancement of the haptoglobin. Level at the patholgoical conditions.
    Autorzy: Parkhomenko Tatiana V., Klicenko Oxana A., Shavlovski Mikhail M., Poletaev Andrey I., Kuznetsova Irina M., Uversky Vladimir N., Turoverov Konstantin K.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR266-BR271, il., bibliogr. 59 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: Human serum albumin (hSA), the major component in blood plasma, fulfills a fundamental biological role as a universal carrier and resevoir in blood plasma, tissues, and secretions. Becaues of essential diversity in the bound ligands, hSA was shown to possess significant structural divergence. In the first paper of this series we reported on that albumin-enriched fractions isolated from serum of glomerulonephritis (GN) patients possesses essential blue shift of intrinsic fluorescence. Identification of this component was the major goal of this study. Material/Methods: Partially purifies SA preparations were isolated from blood plasma of 19 GN patients and 8 healthy donors. These preparations have been analyzed by combination of chromatographic (gel-filtration and hydrophobic sorption) and spectrofluorometric techniques. Results: At least six differented albumin enriched fractions were isolated from blood of GN pateitns. High molecular weight protein fraction with blue shifted intrinsic fluorescence spectrum was segregated. Higher concentration of this fraction may be responsible for higher parameter A values, which is characteristic of protein preparations from GN patietns. Amino acid sequence showed that á-haptoglobin is one of the components of this fraction. Conclusion: Combination of chromatographic methods with monitoring intrinsic fluorescence spectra of albumin-enriched fractions from blood plasma of healthy donors and GN patients represents a useful tool for the description of hSA heterogeneity and for the detection of the changes in the level of disease-related compounds. This approach is also appropriate for the isolation of individual components, different in their parameter A values, from the blood plasma.


    719/2523

    Tytuł oryginału: Effect of hydroxyethyl starch (HAES) on degree and kinetics of erythrocyte aggregation studied with dielectric spectroscopy method.
    Autorzy: Jaroszyński Witold, Keslinka Elżbieta, Wujtewicz Maria, Suchorzewska Janina, Kwiatkowski Bartłomiej
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR272-BR278, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: Colloidal fluids, e.g. hydroxyethyl strach (HAES), used as blood plasma substituted during acute controlled normovolemic hemodilution may cause erythrocyte aggregation. The aim of the presented study was to assess the degree and rate of erythrocyte aggregation in the media containing different concentrations of HAES. Material/Methods: The experiments were carried out on hpearinized venous blood and on erythrocyte suspension in 0.9 p.c. NaCl. Results: Uncer stationary conditions, an increase of blood and erythrocyte suspension relative electric permitivity (î), with an increase of HAES concentration in the sample, was observed after HAES supplementation. Sample flow through a measuring chamber resulted in decrease of the îL value (determined for 100 kHz). Stopping the flow led to non-linear increase of îL values in the function of time, where two components - characterized by rapid and slow variability, respectively, could be distinguished. The increase was characterized by ç1 and ç2 relaxation times, which can be related respectively to the process of erythrocyte rouleaux formation and to the formation of 3-D network aggregates. Conclusions: 1) The values of çL are differentiated by the degree of erythrocyte aggregation due to the presence of HAES, both in whole blood and in erythrocyte suspension in 0.9 p.c. NaCl solution, 2) The degree of erythrocyte disaggregation due to flow increases with the increase of flow intensity and correlates with decreasing çL value, 3) ç1 and ç2, which characterize the kinetics of erythrocyte aggregation, indicate a difference between aggregation processes taking place in whole blood and after hemodilution with HAES.


    720/2523

    Tytuł oryginału: Chromosome alterations reflect clonal evolution in squamous cell carcinoma of the larynx.
    Autorzy: Kujawski Maciej, Rydzanicz Małgorzata, Sarlomo-Rikala Maarit, Gabriel Andrzej, Szyfter Krzysztof
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.BR279-BR282, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The mechanism of multistage carcinogenesis initiated by environmental carcinogens produces clonal evolution of initiated cells to the stage of metastasis. However, the simultaneous co-existence of various cell clones is not excluded. The analysis of chromosome alterations appears to be the best method to assess the clonal composition of a tumor. Material/Methods: Laryngeal tumor specimens and their corresponding metastases to the adjacent lymph nodes (20 pairs) were analysed by comparative genome hybridization (CGH). Results: The profile of gains and losses of DNA copy number was found to be fairly similar in the primary tumor location and in its metastasis. in this study the most frequent losses were found on 3p, 5q, 9p, 13p, and 13q, while gains occurred in 1q, 3q, 5p and 11q. The gains and losses were found more frequently in metastasis than in primary tumor, except for the loss of 3p and the gain of 5p. The bioogical function of the latter chromosome alterations seems to be limited to tumor growth, rather than metastasis formation. Conclusions: A comparison of the profiles of chromosomes alterations in primary tumor locations and metastases indicate that the progression of laryngeal cancer is connected with the clonal evolution of tumor cells.


    721/2523

    Tytuł oryginału: Plasma soluble L-selectin following cardiopulmonary bypass (CPB) in children: is it a marker of the postoperative course?
    Autorzy: Dagan Ovdi, Prince Tal, Ben-Abraham Ron, Vidne Bernardo, Mishali David, Katz Yitshak, Keller Natan, Barzilay Zohar, Paret Gideon
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR467-CR472, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • chirurgia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: There is increasing evidence that cytokine-inducible leukocyte-endothelial adhesion molecules are instrumental in the postoperative inflammatory response following cardiopulmonary bypass (CPB). L-selectin was shown to be one of those neutrophil-endothelial cell adhesion molecules. This study aimed to ivnestigate the relationship of teh soluble adhesion molecule, sL-selectin, and the postoperative course in children undergoing CPB. Material/Methods: To determine the time course of sL-selectin after CPB, serial blood samples of 9 children undergoing CPB were collected from the arterial line or from the bypass circuits preoperatively, on initiation of CPB and 1, 6, 12, 18, 24, and 48 hours postoperatively. Plasma was recovered immediately, aliqoted and frozedn at -70řC until use. Circulating sL-selectin molecules were measured witha sandwich enzyme-linked immunoabosrbent assay (ELISA) technique. there were significant changes in plasma levels of sL-selectin in patients following CPB, and these levels were associated with patient characteristics, operative variables and postoperative course. Low values of sL-selectin significantly correlated with inotropic support, low PRISM score, postoperative hypotension and fever. There was a significant association between the development of postoperative sepsis and low sL-selectin levels. No correlation was found between sL-selectin values and lactate concentration or neutrophil fount. Conclusions: Our results suggest a relation between CPB-induced mediators and both early and late clinical effects...


    722/2523

    Tytuł oryginału: Effect of renin-angiotensin system activation by dietary sodium restriction and upright position on plasma leptin concentration in patietns with essential hypertension.
    Autorzy: Adamczak Marcin, Kokot Franciszek, Chudek Jerzy, Więcek Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR473-CR477, tab., bibliogr. 43 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Both leptin and the renin-angiotensin system (RAS) are involved in the regulation of arterial blood pressure. This study was undertaken to assess the relationship between RAS and plasma leptin concentration in hypertensive patients under conditions of normal and restricted sodium supply and upright postion. Material/Methods: In 31 patietns with essential hypertension (EHP - 14 F, 17 M, age 44 ń 14 years, BMI 29.3 ń 6.4 kg/mý) and 8 healthy subjects (NHS - 4 F, 4 M, age 37 (17 years, BMI 25.3 ń 6.6 kg/mý) plasma leptin cocnentration, plasma renin activity (PRA), and 24-hour urinary sodium exretion (UNa) were evaluated twice: first on a diet containing 100-120 mmol sodium per day and after 8 hours overnight bed rest, and a seond time after 3 days of dietary sodium restriction (10-20 mmol daily) adn 3 horus in upright position. Results: Dietary sodium restriction and upright position was followed by a significant increase in PRA and decrease of UNa. By contrast, plasma leptin concentration showed a moderate decrease both in EHP and NHS. No significant correlation was found between PRA and plasma leptin concentrations in either of the groups examined. Cocnlusion: From the results obtained in this study we may conclude that dietary sodium restriction and upright positon exerts only a moderate effect on plasma leptin concentration, in contrast to PRA, in both hypertensive and normotensive subjects.


    723/2523

    Tytuł oryginału: Phenotypic characterization of infilatrates in dilated cardiomyopathy - diagnostic significance of T-lymphocytes and macrophages in inflammatory cardiomyopathy.
    Autorzy: Noutsias Michel, Pauschinger Matthias, Schultheiss Heinz-Peter, Khl Uwe
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR478-CR487, il., tab., bibliogr. 55 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dilated cardiomyopathy (DCM) is linked to inflammatory cardiomyopathy (InfCM). To gain a profound insight into the underlying mechanisms, we phenotypically characterized pan leukocytes (CD18), naive T-lymphocytes (CD3, CD2, CD4, CD8), activated lympocytes (LFA-1, LFA-3, VLA-4, ICAM-1, CD69, CD45RO), macrophages (Mac-1, 27E10), B-lymphocytes (CD19) and NK-cells (CD57) in DCM and control hearts. Material/Methods: Biopsies from DCM patietns (n = 164, LVEF 40 p.c.) and specimens from non-cardiac death causes (controls; n = 17) were immunostained. Biopsies exceeding 2.0 CD3+ lymphocytes per high power field/hpf and/or 1.5 CD3+ lymphocytes/hpf with numerous foci and HLA class I/DR abundance were evaluated positive for InfCM. Results: InfCM+ biopsies (n = 102; 63 p.c.) demonstrated significantly increased infiltrates with respect to all studied phenotypes except for CD19 and CD57 when compared with both DCM biopsies negative for InfCM (n = 62) and the controls, whereas the latter two groups did not differ (Tukey-Kramer analysis). Virtually all phenotypes correlated with one another in multivariate analysis (except for B-lymphocytes and NK cells). Whereas HLA class I/DR abundance was present in 14 p.c. of the controls and 26 p.c. of the DCM biopsies not yielding InflCM, InfCM+ biopsies demonstrated significantly ( 0.001) higher frequencies of HLA abundance (76 p.c.). Conclusions: The inflammatory process in InfCM comprises T-lymphocytes and macrophages, whereas B-lymphocytes and NK-cells are not significantly increased. InfCM is associated with HLA induction...


    724/2523

    Tytuł oryginału: Assessment of the prevalence of iron deficiency anemia, by serum ferritin, in pregnant women of Southern Iran.
    Autorzy: Karimi Mehran, Kadivar Raheem, Yarmohammadi Hooman
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR488-CR492, tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • hematologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Background: Iron-deficiency anemia (IDA) is a public health problem in the developing and even industrialized countries. Pregnant women and children under 5 years of age are among the high-risk population. Our main objectives in this study were to obtain the prevalence of IDA in pregnant women by routine methods and by serum ferritin. Material/Methods: We analysed the blood of 270 healthy pregnant mothers, 16 weeks of gestational age. A series of determinations were conducted to determine haemoglobin concentration (Hb); red blood cells count (RBC); serum ferritina and other indexes. Then a questionnaire for epidemiolgoical data, type of diet, level of education, laboratory data, etc. was filled. Results: The mean values (SD) of haematological indexes were as follows: Hb 12.07 ń 1.5 g/dl; serum ferritin 24.87 ń 19.32 ng/ml; mean corpuscular haemoglobin concentration (MCHC) 31.9 ń 1.4 g/dl; mean corpuscular volume (MCV) 82.2 ń 9 fl and mean corpuscular haemoglobin (MCH) 26.4 ń 3.2 pg. 28.5 p.c. of the subjects were anaemic at the time of the study according to serum ferritin (SF 12 ng/ml) and 16.7 p.c. fo the mothers had low serum Haemoglobin (Hb 11 g/dl) (P - 0.005). There was a positive correlation (r = 0.76; P = 0.01) between Hb concentration and serum ferritin levels. Conclusion: The prevalence of IDA was 28.5 p.c., which is the same as teh prevalence found in other developing coutnries (25-35 p.c.). This shows that in southern Iran we are still far behind the health status in the industrialized countries (5-8 p.c.).


    725/2523

    Tytuł oryginału: CT-guided transthoracic fine needle aspiration of pulmonary lesions: accuracy and complications in 294 patients.
    Autorzy: Arslan Sulhattin, Yilmaz Adnan, Bayramgrler Birol, Uzman ™zlem, šnver Edhem, Akkaya Esen
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR493-CR497, tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • radiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of this study was to prospectively evaluate the effectiveness of CT-guided transthoracic fine needle aspiration in the diagnosis of pulmonary lesions and to determine the complication rate of this procedure. Material/Methods: A prospective review was udnertaken of 316 patietns who underwent CT-guided transthoracic fine needle aspiration performed at our center between October 2000 and April 2001. Twenty-two patietns were excluded because no final diagnosis was achieved. The present study included 294 patietns. All fine needle aspirations were performed with a 22-gauge aspirating needle under CT guidance. Results: An accurate diagnosis was made in 228 of 259 malignant lung lesions (88 p.c.). A speicific diagnosis was obtained in 34.3 p.c. of the benign lesions. The sensitivity for malignancy and specificity for benign lesions were 88 p.c. and 100 p.c., respectively. Positive and negative predictive values were 100 p.c. and 53 p.c., respectively. Tehre was no fals-positive diagnosis for malignancy. Sensitivity was 87 p.c. for centrally located lesions and 89.3 p.c. for peripherally located lesions (p 0.05). Complications included pneumothorax, 24 of 294 cases (8.2 p.c.); chest tube, 3 cases (12.5 p.c.); minor hemoptysis, 5 cases (1.7 p.c.); and pulmonary hemorrhage, 4 cases (1.4 p.c.). Conclusions: Our results suggest that this procedure has high diagnostic accuracy and an acceptable rate of complications.


    726/2523

    Tytuł oryginału: Spectrum and proteinase production of yeasts causing vaginitis in Saudi Arabian women.
    Autorzy: Al-Hedaithy Saleh S. A.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR498-CR501, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Yeast vaginitis is a common infection. Data on the identity and prevalence of the etiological species would serve both epidemiological and therapeutic ends. Proteinase secreation by the invading yeast has been implicated in facilitating infection. Hence a prospective study was conducted to determine the species causing vaginitis in women from Saudi Arabia and the yeast's ability to produce proteinase. Material/Methods: The subjects were patients with clincial signs of vaginitis. A high vaginal swab specimen from each patient was cultured, and only women yielding heavy yeast growth were enrolled. The isolated yeasts were identified by routine procedures, then evaluated for proteinase production in a medium containing bovine serium albumin. Results: A total of 500 patients were studied. Candida albicans was the major species to cause vaginitis (59 p.c.), followed by C. glabrata (31 p.c.), C. tropicalis (4 p.c.), C. krusei (3.2 p.c.), Saccharomyces cerevisiae (1.6 p.c.), C. parapsilosis (0.6 p.c.), and C. kefyr (0.6 p.c.). All isolated of C. albicans and C. parapsilosis and 95 p.c. of C. ropicalis produced proteinase, while isolates from the remaining speices did not. Conclusions: These results indicate that 59.6 p.c. of yeast vaginitis in women from Saudi Arabia is caused by C. albicans, and 31.6 p.c. by C. glabrata. Of relatively low prevalence were C. tropicalis and C. krusei. The study also revealed that both proteinase producers and non-producers were involved in causing vaginitis, indicating that proteinase secretion is not an essential factor in the pathogeneis of yeast vaginitis.


    727/2523

    Tytuł oryginału: Changes of arterial pressure in patients with hyperthyroidism during therapy.
    Autorzy: Marcisz Czesław, Jonderko Gerard, Kucharz Eugeniusz J.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR502-CR507, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hyperthyroidism affects the circulatory system, producing an increase in cardiac output and an enhanced vascular bed volume. These phenomena are important in the regulation of blood pressure. The present study was designed to evaluate the effects of short- and longterm treatment of hyperthyroidism on arterial pressure, taking into account the indices of cardiac function and peripheral vessel resistance. Material/Methods: Fifty-one patients with hyperthyroidism and 30 healthy controls were investigated. The patients were examined before treatment, two weeks after initiation of therpay, and after attainment of a euthyroid state. Thiamazole was used as the antithyroid agent. Blood pressure and serum thyroid hormones were determined and ultrasonographic examination was performed on all teh subjects, after the application of a diet containing 120 mmol of sodium and 70 mmol of potassium for three days. Results: Patietns with hyperthyroidism had higher systolic blood pressure and lower diastolic blood pressure than the healthy controls. After short-term treatment, systolic blood pressure returned to normal, while diastolic blood pressure was normalized only after long-term treatment. Conclusion: Regulation of blood pressure in patients with hyperthyroidism is a complex process. Systolic blood pressure is mainly related to caridac output and returns to normal range shortly after the initiation of tehrapy, while diastolic blood pressure is related to peripheral vascualr resistance and is normalized after long-term treatment.


    728/2523

    Tytuł oryginału: Left atrial function in patients with renal transplantation.
    Autorzy: Rysz Jacek, Goch Aleksander, Wilk Radosław, Grycewicz Tomasz, Luciak Marek, Goch Jan Henryk
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR508-CR511, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Chronic renal failure leads to structural changes and cardiac functional abnormalities known as uremic cardiomyopathy. Eliminating excess water and improving the composition of the inner environment leads to at least partial cardiac function improvement, which is reflected primarily in favorable changes in left ventricular indices. The aim of our study was to evaluate left atrial function in patients after renal transplantation and compare them with clinically healthy subjects. Material/Methods: 10 renal transplant patients (2 women, 8 men; mean age 47.8 ń 6.4 years), treated before transplantation with repeated hemodialysis, were subjected to standard transthoracic echocardiographic examination. Atrial function was evaluated in M-mode and 2D projections and by cross-sectional Doppler echocardiography. The results obtained were compared with 16 healthy controls (9 women, 7 men; mean age 39.7 ń 9.4 years). Results: Maximal left atrial dimension (LAmax), left atrial dimension obtained in M-mode of the long axis in parasternal projection (LAa), ejection time (ETlp) and pre-ejection period (PEPlp) were significantly higher in renal transplant patietns than in healthy subjects. In both investigated groups there were no differences in minimal left atrial dimensions (LAmin), PEPlp/Etlp ratio, P wave time (P), left atrial fiber shortening fraction (FS p.c.lp), passive evacuate fraction (FBOlp), total left atrial fraction (FClp), or IElp ratio. Conclusion: Abnormal function of the left atrium in the course of uremia treated with repeated hemodialysis is not fully corrected after renal transplantation despite the elimination of many cardiovascular complciations observed in chronic renal disease.


    729/2523

    Tytuł oryginału: Sulfonylurea receptor gene 16-3 polymorphism - association with sulfonylurea or insulin treatment in type 2 diabetic subjects.
    Autorzy: Zychma Marcin J., Gumprecht Janusz, Strojek Krzysztof, Grzeszczak Władysław, Moczulski Dariusz, Trautsolt Wanda, Karasek Dariusz
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR512-CR515, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The presence of a complex phenotype of type 2 diabetes results from impaired insulin secretion and action, whereas the emchanism of action of sulfonylurea derivatives, most commonly used int he treatment of type 2 diabetes, is based on their ability to directly inhibit the ATP-sensitive potassium channel (KATP), which leads to á-cell depolarization, subsequent influx of calcium and then insulin exocytosis. It has recently been demonstrated in healthy subjects that molecular variants of the gene encoding for the KATP subunit - sulfonylurea receptor gene (SUR1) are associated with a decreased response of insulin secretion to intravenous injection of tolbutamide, a suflonylurea derivative. In thid study we tested whether a molecular variant of the SUR1 gene, 16-3t, has a different distribution in type 2 diabetic patients with early failure of sulfonylurea therapy, compared to patients treatable iwth sufonylurea despite long diabetes duration. Material/Methods: The SUR1 polymorphism was genotyped in 68 type 2 diabetic patietns who required insulin treatment and had known diabetes duration ó 5 years, compared to 99 patients receiving oral agents (sulfonylurea alone or in combination with metformin or acarbose) with known diabetes duration of at least 15 years. Results: We obseverd no significant differences in SUR1 16-3t genotype distributions or allele frequencies between the two examined groups. Conclusion: Our study provides evidence against a major impact of the SUR1 c16-3t polymorphism on the long-term effectiveness of therapy with sulfonylurea derivatives in type 2 diabetic patients.


    730/2523

    Tytuł oryginału: Hepatitis B virus serologic markers and anti-hepatitis B vaccination in patietns with diabetes.
    Autorzy: Halota Waldemar, Muszyńska Mirosława, Pawłowska Małgorzata
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR516-CR519, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In Poland HBV infections are mainly the result of nosocomial infections or risky behavior. Active prevention plays a crucial role in limiting such infections. Pateitns suffering from insulin-dependent diabetes (type 1) incur high risk of infection with hepatotropic viruses because of frequent hospitalization and blood tests. The aim of our study was to determine the frequency of cocurrence of serological markers of HBV infection among patietns with diabetes type 1, to evaluate the humoral response to HBV vaccine depending on dosage, and to evaluate the influence of past HBV infections on vaccination response. Material/Methods: 299 diabetic patients were vaccinated against hepatitis B with Engerix B in two doses (20 ćg or 40 ćg), on a 0-1-6 month schedule. The humoral response to the vaccination was evaluated in the 5th and 8th months after the first dose of vaccine according to sex, dose and previous detection of anti-HBc in serum. Serologic markers of HBV infection were detected with the immunoenzymatic-fluorescent ELFA method, with bioMerieux tests using the VIDAS system. Results: 98.7 p.c. of patients achieved protective anti-HBs titer after vaccination. Women respodned better than men. There were nod ifferences in mean anti-HBs concentration by vaccine dose. Patietns with previous serum anti-HBc achieved anti-HBs titers (p 0.00001). Concluion: The frequency of anti-HBc among patietns with diabetes confirms the widespread risk of HBV infection in teh Polish population. Diabetics should be vaccinated against hepatits B with standard doses. Diabetics with anti-HBc in serum can be vaccinated with a single dose.


    731/2523

    Tytuł oryginału: Ozone therapy and the activity of selected lysosomal enzymes in blood serum of patietns with lower limb ischaemia associated with obliterative atheromatosis.
    Autorzy: Tafil-Klawe Małgorzata, Woźniak Alina, Drewa Tomasz, Ponikowska Irena, Drewa Joanna, Drewa Gerard, Włodarczyk Konrad, Olszewska Dorota, Klawe Jacek, Kozłowska Róża
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR520-CR525, tab., bibliogr. 49 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The paper compares the effects of ozone therpay and conventional balneological methods on health conidition of patietns with obliterative atheromatosis and on serum activity of three lysosomal enzymes. Material/Methods: Sixty-four patietns with lower limb ischaemia in the course of obliterative atheromatosis (without diabetes) were nerolled in the study. Thirty-two patietns were treated with ozone administered by intravenous infusions and 30-minute aerosol oxygen-ozone baths. A comparative group was formed of 32 patietns treated with traditional balneology. There was also a control group made u p of 30 healthy subjects. Ozone tehrapy as well as traditional balenology were administered daily for the period of 10 days, excluding Saturdays and Sundays. Blood for biochemical analysis was collected from elbow vein in the following time intervals: 24 hours before ozone therpy or classical balneology, one hour after therpay and on the 10th day of treatment. The activity of catehpsin D, acid phosphatase and arylsulphatase as well as the levels of ŕ-1-antitrypsin (protease inhibitor) were determined in blood serum of patietns with obliteraitve atheromatosis. Results: In patients who received ozone therapy the activity of analysed lysosomal hydrolases returned to the values typical for healthy subjects. Patietns' general condition also improved. The use of traditional balneological methods did not result in any significant change either in the activity of lysosomal hydrolases, the level of ŕ-1-antitrypsin or general condition of patients. Conclusions: Ozone therapy administered by intravenous infusions and aerosol oxygen-ozone baths of lower extremities yields much better therapeutic results in comparison with classical balneology.


    732/2523

    Tytuł oryginału: TH1/TH2 balance in the subretinal fluid of patients with rhegmatogenous retinal detachment.
    Autorzy: Lewandowska-Furmanik Maria, Pożarowska Dorota, Pożarowski Piotr, Matysik Anna
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR526-CR528, tab., bibliogr. 6 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • okulistyka
  • pediatria
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The pathogenesis of rhegmatogenous retinal detachemnts remains unclear, but some data suggest immune system involvement. Cytokines are substances secreted by cells in order to modulate the function of other cells. They exert primarily local effects. Because the TH1/TH2 balance is crucial in the immune response, the predominance of one cytokine profile in subretinal fluid may be of particular importance in understanding its pathogenesis. Material/Methods: We measurred the titres of IL-10 and tIL-12 in the subretinal fluid of 36 rhegmatogenous retinal detachment patients using ELISA assays. Results: The mean level of IL-10 and tIL-12 in the subretinal fluid was 4.75 pg/ml and 106.5 pg/ml, respectively. Conclusion: It would appear that IL-10 and IL-12 are produced by cells in subretinal fluid, and their presence may be evidence for an existing inflammatory process. Despite the tendency to decreased cytokine concnetration over time and the tendency to higher concentrations of IL-TH1- or TH2-type response was observed.


    733/2523

    Tytuł oryginału: Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat.
    Autorzy: Villa Bianca Roberta d'Emanuele di, Wayman Nicol S., McDonald Michelle C., Pinto Aldo, Sharpe Martyn A., Chatterjee Prabal K., Thiemermann Christoph
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR1-BR7, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Reactive oxygen species contribute to the multiple organ failure shock. Here we investigate the effects of a salen-manganese complex, which exhibits both superoxide dismutase and catalase activity (EUK-134), on the circulatory failure and the renal and liver injury and dysfunction caused by endotoxin in the anaesthetised (thiopentone, 120 mg/kg) rat. Male Wistar rats were anaesthetised with hiopentone sodium (120 kg i.p.) and instrumented for the measurements of systemic haemodynamics. Animals received lipopolysaccharide (LPS, E. coli, 6 mg/kg i.v.) or saline and were treated with either EUK-134 (0.3 or 1 mg/kg bolus injection folloowed by an infusion of 0.3 or 1 mg/kg/h) or its vehicle (saline). After 6 h of endotoxaemia, blood was taken to evaluate biochemical parameters of organ injury and dysfunction. All data are mean ń s.e. mean of n observations. Statisstical comparisons were made with a ANOVA followed by Dunner's test for mulitiple comparisons. Endotoxaemia for 6 h caused hypotension, renal dysfunction, liver injury, skeletal-muscle injury and pancreatic injury. Treatment of rats with EUK-134 attenuated the reanl dysfynction as well as the liver and skeletal muscle injury (but not the pancreatic injury) caused by endotoxin. Thus, an enhanced formation of reactive oxygen species importantly contribute to the organ injury and dysfunction associated wtih endotoxic shock. We propose that small molecules, which have the catalytic activity of both superoxide dismutase and catalase, may represent a novel therapeutic approach for the therapy of endotoxic shock.


    734/2523

    Tytuł oryginału: NOC/oFQ activates PKC and generates superoxide to impair hypotensive cerebrovasodilation after hypoxia/ischemia.
    Autorzy: Armstead William M.
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR8-BR14, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Previous studies have observed that hypotensive pial artery dilation was blunted following global cerebral ischemia in the piglet. In unrelated studies, superoxide (O-2) contributed to impaired hypotensive cerebrovasodilation following traumatic brain injury in the rat while the opioid nociceptin/orphanin FQ (NOC/oFQ) generated O-2 via activation of protein kianse C in the piglet. This study determined the contribution of NOC/oFQ, PKC activation and O-2 generation in hypoxic ischemic hypotensive cerebrovasodilation impairment. Anesthetized newborn pigs equipped with a closed cranial window were used. Global cerebral ischemia was produced via elevated intracranial pressure. Hypoxia, via inhalation of nitrogen, decreased P02 to 34 ń mmHg. Topical NOC/oFQ(10**-10 M), the CSF concentration following hypoxia/ischemia, had to effecton pial artery diameter by itself but attenuated hypotension (mean arterial blood pressure decrease of 44 ń 2 p.c.) induced pial artery dilation (33 ń 1 vs 19ń 2 p.c.). Coadministration of the PKC inhibiator chelerythrine (10**-7 M) or the O-2 scavenger polyethylene glycol superoxide dismutase and catalase (SODCAT) with NOC/oFQ (10**-10 M) partially prevented hypotensive pial dilation impariment (34 ń 2 vs 28 ń 1 p.c. fopr SODCAT). Hypotensive pial artery dilation was blunted by hypoxia/ischemia but such dilation was partially protected by the NOC/oFQ receptor antagonist [F/G] NOC/oFQ (1-13) NH2 (10**-6 M), chelerythine or SODCAT (34 ń 1 vs 7 + 2 vs 21 ń 2 p.c. for sham, H/I and H/I + SODCAT, respectively).


    735/2523

    Tytuł oryginału: Detection of gsp somatic mutation through direct sequencing of heteroduplex alleles disclosed by denaturing gradient gel electrophoresis.
    Autorzy: Fragoso Maria C. Barisson Villares, Lado Valeria S., Latronico Ana C., Frazzatto Eliana T. Salgado, Russell Alan J., Mendonca Berenice B.
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR15-BR18, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The identification of somatic mutations in tissues is often difficult when the number of normal alleles in the tissue far exceeds the number of mutation was not possible by direct sequencing and present a new approach that improves the identification of gsp somatic mutations. Genomic DNA was extracted from frozen tissue of a human ovarian stromal Leydig cell tumor. Exons 8 and 9 of the Gsŕ gene were amplified by PCR and despite the abnormal migration pattern at this first DGGE, direct sequencing of the PCR product did not reveal mutations, probably due to the small amonunt of mutant alleles. To improve this amount, the PCR products were re-amplified using as template the excised products of the mutant homoduplex and heteroduplex bands obtained at the first DGGE. This approach resulted in the enhancing of the mutant homoduplex bands whereas the heteroduplex bands remained unchanged at the second DGGE. Direct sequencing of the second round PCR clearly identified the mutation R201C in the ovarian Leydig cell tumor. We have demonstrated a relatively rapid, convenient and reliable method to improve gsp somatic mutation detection combining a second DGGE of the PCR products obtained from the heteroduplexes and mutant homoduplex bands disclosed in a first DGGE followed by direct sequencing.


    736/2523

    Tytuł oryginału: Mechanism of the contractile effects of galantide and Galanin (1-14) [ŕ-aminobutyric acid8]scyliorhinin-I in rat isolated fundus strips.
    Autorzy: Korolkiewicz Roman P., Konstański Zdzisław, Rekowski Piotr, Szyk Agnieszka, Ruczyński Jarosław, Dąbkowski Jarosław, Ujda Marek, Korolkiewicz Konstanty Zbigniew, Petrusewicz Jacek
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR19-BR23, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: The study was undertaken to establish the pharmacological basis of the stimulatory activity of galantide (M15) and galanin(1-14)-ŕ-aminobutyric acid8-[Abu8])scyliorhinin-I [Scy-I] in gastric smooth muscle. Material/Methods: Isotnic contractions of the isolated, longitudinal rat gastric fundus strips were recorded. Results: Galanin, galanin(1-15)-NH2, M15 and galanin(1-14)-[Abu8]Scy-I elicited concentration-dependent contractions. Their EC50s equaled 12.95, 174, 70.06 and 187 nM respectively. Hill's coefficients for galanin and galanin(1-15)-NH2 were not different from unity, indicating an interaction of one peptide molecule with one receptor accoridng to the principles of classical receptor theory. Hill's coefficients were 0.73 and 1.56 for M15 and galanin (1-14)-[Abu8]Scy-I, respectively, a value significantly different from unity. Cold-storage denervation, tetrodotoxin-TTX (1 ćM), spantide 100 ćM) and NK1-3 receptor antagonists SR140333, 48968, 142801 (up to 10 ćM) notably diminished Mf15, galanin (1-14)-[Abu8]Scy-I, SP(5-11) and [Abu8]-Scy-I evoked contractions without affecting activities of galanin and galanin(1-15)-NH2. Additionally, cross-desensitization experiments attenuated activity of M15 and galanin(1-14)-[Abu8]Scy-I without any noticeable action on galanin or galanin(1-15)-NH2. Conclusions: The action of chimeric peptides on the smooth muscle of the rat gastrointestinal tract depended not only on the myogenic interaction of those peptides with galanin binding sites, but also on the activation of tachykinin receptors or the release of endogenous mediators from the presynaptic terminals.


    737/2523

    Tytuł oryginału: Soluble cytokine receptors in renal vasculitis and lupus nephritis.
    Autorzy: Tesar Vladimir, Jirsa jr Milan, Zima Tomas, Kalousova Marta, Bartunkova Jirina, Stejskalova Alena, Dostal Ctibor, Zabka Jiri
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR24-BR29, tab., bibliogr. 49 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: The activation of various cytokines, e.g. TNFŕ, IL-1 and/or IL-6, may play an important role in the pathogenesis of renal vasculitis and lupus nephritis (LN). The systemic effect of these cytokines may be modulated by their circulating soluble receptors. The plasma levels of cytokine receptors may thus also be markers of the activation of these cytokines. Material/Methods: The plasma levels of TNFŕ, its soluble receptor p75 (sTNF-RII), IL-6, and the soluble IL-6 receptor (sIL-6R) were measured using ELISA in 17 patients with ANCA-positive renal vasculitis (12 active - ANCA-A, 7 in remission ANCA-R), 9 patients with active lupus nephritis (LN), and 5 healthy subjects. Results: Patients with LN had increased plasma levels of TNFŕ, sTNF-RII, IL-6 and sIL-6R in comparison with controls. Patients with ANCA-A also had increased plasma levels of TNFŕ, sTNF-RII adn sIL-6R in comparison with controls, but the increases in the plasma level of IL-6 was not statistically significant, due to the large standard deviation. Patients with ANCA-R had increased plasma levels of sTNF-RII in comparison to controls, but the plasma levels of TNFŕ were significantly lower in ANCA-R than in NANCA-A. While the ratio of TNFŕ to sTNF-RII was significantly lower in all groups of patients than in the acontrols, the ratio of IL-6 to sIL-6R was significantly increased only in LN in comparison to controls. Conclusions: While increased plasma levels of TNFŕ may be a nonspecific marker of the activity of ANCA-positive renal vasculitis and LN...


    738/2523

    Tytuł oryginału: Frequency, consequences and pharmacological treatment of gastroesophageal reflux in children with cystic fibrosis.
    Autorzy: Brodzicki Jacek, Trawińska Maria, Korzon Maria
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR529-CR537, tab., bibliogr. 42 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Gastroesophageal reflux (GER) may aggravate chronic bronchopulmonary diseases. The study evaluated GER frequency and characteristics in children with Cysti Fibrosis (CF) as well as its consequences and pharmacological treatment. Material/Methods: 40 CF children aged 1.3 to 20 years were examined. The study methodology involved: medical files analysis, anamnesis, physical examination, growth status estimation, esophageal pH-metry and upper gastrointestinal tract endoscopy with histological examination of esophageal biopsies. Results: Based on pH-metry results, the diagnosis of GER was established in 22 children (55 p.c.). Mild GER (Index Reflux - IR 5-10 p.c.) was found in 12 children (54.5 p.c.), moderate GER (IR 10-20 p.c.) in 7 (31.8 p.c.) and severe GER (IR 20 p.c.) in 3 (13.6 p.c.). Ten patietns with moderate or severe GER underwent endoscopy, which revealed GER-related esophagitis in 8 cases. There was no statistical difference of GER frequency and degree according to: age, sex, growth status, presence of type DeltaF508 mutation in CFTR genome and typical GERD symptoms. According to the ESPGAN proposition, cisapride or cisapride with ranitidine medication was instituted. Treatment analysis was performed in 19 cases after successful follow-up examinations carried out three months later, indicating a significant decrease in reflux index, the longest episode duration and the numer of episodes longer than 5 minutes. Improvement of endoscopic picture was noticed after treatment. Conclusion: High frequency of gastroesophageal reflux and its consequences among...


    739/2523

    Tytuł oryginału: Concentration of á2-microglobulin and percentage of CD4 lymphocytes in peripheral blood in patients with chronic HCV infection during IFN-ŕ therapy.
    Autorzy: Łapiński Tadeusz Wojciech, Kot Aldona, Prokopowicz Danuta
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR538-CR542, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: We evaluated the serum á2-MG concentration and CD4 lymphocytes in the blood of HCV infected patietns during IFN-ŕ therapy, searching for a correlation between á2-MG concentration. CD4 lymphocytes, and tehrpay effectiveness, as well as morphological changes in the liver. Material/Methods: 24 patietns with chronic HCV infection were treated with IFN-ŕ2a. The serum á2-MC concentration was measured with the use of a method based on teh fluorescent modification of the immunoenzymatic technique. The percentage of T CD4 lymphocytes in the blood was measured by direct immunofluorescence using monoclonal antibodies. Results: The number of CD4 lymphocytes in teh blood was lower in the HCV infected patients (864/ml; preferred values from 1,300 to 2,100/ml), the á2-MG concnetration was elevated (2.37 mg/dl) in comparison to the preferred values (1.52 mg/dl; p 0.05). IFN-ŕ therapy caused an increase in the á2-MG. The highest increase was observed among patients who did not eliminate the virus (from 2.39 to 4.10 mg/dl). In the initial period of interferon therapy an increase was observed (from 729 to 1082/ml) in the number of CD4 lymphocytes among those patients who eliminated the virus and a decrease (from 947 to 853/ml) in the patietns who were not treated successfully. Conclusions: A significant increase in á2-MG during interferon therapy in patietns with chronic HCV infection is a predictor of poor outcome. An increase in the number of CD4 lymphocytes in the initial phase of treatment suggests a positive outcome.


    740/2523

    Tytuł oryginału: Cheyne-Stokes respiration during sleep: a possible effect of body position.
    Autorzy: Oksenberg Arie, Arons Elena, Snir David, Radwan Henryk, Soroker Nachum
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CS61-CS65, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Cheyne-Stokes Respiration (CSR) is a common finding in Chronic Heart Failure and Stroke patients. The body position effect during sleep on obstructive breathing abnormalities is well known. However, the effect of body position during sleep on breathing abnormalities of central type like CSR has not been well documented. Material/Methods: Six sleep studies (two complete Polysomnographic (PSG) evaluations and four Pulse Oximetry recordings (PO)), were carried out in a 57-year-old female patient with a recent Cerebro Vascular Accident (CVA who had both Obstructive Sleep Apnea (OSA) and CSR. Results: The first PSG was carried out tow months post-stroke an drevealed a severe, continuous CSR pattern during Non Rapid Eye Movements (NREM) sleep (mainly with central apneas), and Obstructive Sleep Apnea (OSA) during Rapid Eye Movements (REM) sleep, independent of body positon: Supine Respiratory Disturbance Index (SRDI) = 85.2 and Lateral RDI (LRDI) = 95.4. A second PSG was performed three months later after an overall clinical improvement and showed a complete disappearance of CSR during NREM sleep and OSA during REM sleep in her lateral posture (LRDI = 0), while the RDI in the supine posture was only slightly improved (SRDI = 73.2). The CSR pattern was less severe and was characterized mainly by central hypopneas. Two PO recordings between the PSG studies showed similar improvement trends. Two additional PO recordings, two and three weeks after the last PSG (the first one with the patient lying supine and the second one with the patient lying on her side through-out the night),...


    741/2523

    Tytuł oryginału: Psychiatric symptoms in a patient with the clincial features of MELAS.
    Autorzy: Kiejna Andrzej, DiMauro Salvatore, Adamowski Tomasz, Rymaszewska Joanna, Leszek Jerzy, Pąchalska Maria
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.CS66-CS72, il., tab., bibliogr 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: This article presents a case study of a 32-year-old Polish male patient clincally diagnosed with the MELAS syndrome, the second such patient reported in this country. Case report: The patient presents with a long history of neurological episodes, consisting of acute neurological deficitis suggestive of CVA with no evidence of focal lesion and very rapid remission of symptoms. These episodes began when the patient was 19 years old and have recurred since that time at intervals of 1-5 years. A recent psychiatric episode with unusual visual hallucinations brought the case to the attention of the present authors, who initiated further diagnostic testing. A muscle biopsy revealed ragged red fibers. Conclusions: The features in this case meet the diagnostic criteria for a clincial diagnosis of MELAS, pending confirmation of a pathogenic mutation.


    742/2523

    Tytuł oryginału: Thermal effect of intravascular MR imaging using an MR imaging-guidewire: an in vivo laboratory and histopahtolgical evaluation.
    Autorzy: Yang Xiaoming, Yeung Christopher J., Ji Hongxiu, Serfaty Jean-Michel, Atalar Ergin
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.MT113-MT117, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • radiologia
  • hematologia
  • kardiologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Background: Intravascular magnetic resonance (MR) imaging to guide interventional procedures is a rapidly growing field. A primary concern with these new techniues is their thermal safety. The purpose of this study was to evaluate, in vivo, the thermal effect of an MR imagingguidewire (MRIG) for intravascular MR imaging (IV MRI). Material/Methods: Two indications of potentially adverse local heating were investigated: blood coagulation disorders and pathologica changes in target vessels. Experiments were performed on ten rabbits with a 1.5 T MR scanner. Using a 0.64-mm MRIG as the RF receiver, we imaged the target aorta using a fast spin-echo pulse sequence with an average spcific absorption rate (SAR) of 0.6 W/kg. The total MR imaging time was approximately 70 minutes. Results: There were no abnormal value changes of the coagulation factors between pre- and post-IV MRI, no clinical manifestations of blood coagulation disorders, and, histopathologically, no thermal damage in target vessels. Conclusions: This study demonstrates, from a pathophysiological point of view, the potenial safe use of the MR imaging-guidewire for intravascular MR imaging. Further study is required to precisely define the boundaries of these safe operating parameters.


    743/2523

    Tytuł oryginału: Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.
    Autorzy: Detter Christian, Boehm Dieter H., Reichenspurner Hermann, Deuse Tobias, Arnold Martin, Reichart Bruno
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.MT118-MT123, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Recently, the ZEUSTM Robotic Surgical System has been introduced to increase the precision of endoscopic cardiac surgery. This study investigated its clinical use for endoscopic coronary artery bypass grafting. Material/Methods: Between 1998 and 2001, 41 patients with single and multivessel disease were operated on using the ZEUSTM system. The robotic system was introduced step by step into clinical practice. Initially, the system was used only for endoscopic internal mammary artery (IMA) harvest (n = 12), later for coronary anastomoses on the arrested (n - 13) or beating heart after median sternotomy (n = 6), and finally for endoscopic coronary bypass grafting on either the arrested (n = 2) or beating heart (n - 8). Results: Endoscopic IMA harvest ranged from 48 to 110 min and was completed in all cases. In the sternotomy group, the robotic anastomosis time averaged 21 min on the arrested and 25 min on the beating heart, respectively (n.s.). In the endoscopic cases, the average time for endoscopic anastomosis was 41 min on the arrested and 36.5 min on the betaing heart (n.s.), with an overall duration of surgery between 4.0 and 8.0 hours. One endoscopic case was intraoperatively converted to a MIDCAB procedure with manual anastomosis. THe total patency rate of all graft anasomoses, confirmed by early postoperative angiographic control, was 97 p.c. One patient underwent reopartion with an uneventful postoperative course. Conclusions: The present study demonstrates the feasibility of endoscopic coronary revascularization using a computer-assisted surgical robotic system on the arrested and beating heart in selected patients.


    744/2523

    Tytuł oryginału: Towards a semantic medical Web: HealthCyberMap's tool for building an RDF metadata base of health information resources based on the Qualified Dublin Core Metadata Set.
    Autorzy: Boulos Maged N. Kamel, Roudsari Abdul V., Carson Ewart R.
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.MT124-MT136, il., bibliogr. 52 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: Background: HealthCyberMap (http://healthcybermap.semanticweb.org/) aims at mapping Internet health information resources in novel ways for enhanced retrieval and navigation. This is achieved by collecting appropriate resouce metadata in an unambiguous form that preserves sematics. Material/Methods: We modelled a qualified Dublin Core (DC) metadata set ontology with extra elements for resource quality and geographical provenance in Prot‚g‚-2000. A metadata collection form helps acquiring resource instance data within Prot‚g‚. The DC subject field is populated with UMLS terms directly imported from UMLS Knowledge SOurce Server using UMLS tab, a Prot‚g‚-2000 plug-in. The project is saved in RDFS/RDF. Results: The ontology and associated form serve as a free tool for building and maintaining and RDF medical resource metadata base. The UMLS tab enables browsing and searching for concepts that best describe a resource, and importing them to DC subject fields. The resultant metadata base can be used with a search and inference engine, and have textual and/or visual navigation interface(s) applied to it, to ultimately build a medical Semantic Web portal. different ways of exploiting Prot‚g‚-2000 RDF output are discussed. Conclusion: By making the context and semantics of resources, not merely their raw text and formating, amenable to computer 'understanding', we can build a Semantic Web that is more useful to humans than the current Web. This requires proper use of metadata and ontologies. Clinical codes can reliably describe the subjects of medical resources, establish the semantic relation-ships (as defined by underlying coding scheme) between related resources, and autmoate their topical categorisation.


    745/2523

    Tytuł oryginału: Microcirculation in the diabetic foot as measured by a multichannel laser Doppler instrument.
    Autorzy: Karnafel Waldemar, Juskowa Joanna, Maniewski Roman, Liebert Adam, Jasik Mariusz, Zbieć Anna
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.MT137-MT144, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of this study was to investigate microvascular perfusion in insulin-dependent diabetic patients at various locations on the foot, and to determine which part of the foot is most sensitive to microangiopathic changes. All the parameters of postocclusive reactive hyperemia calculated from multichannel laser Doppler recordings were also evaluated to find the most valuable measure for diabetes examination. Material/Methods: Our study involved 65 subjects divided into four subgroups: male and female controls, and male and female IDDM patients without overt complications. The measurements were performed with a multichannel laser Doppler perfusion monitor using surface probes located in the distal parts of the lower limbs. The occlusion test was performed using a cuff located on the limb above the knee. Multivariate discriminatory analysis was used to evaluate the data. Results: The most valuable data were obtained by recordings from the laser-Doppler probes located on the hallex and the base of the little toe. The maximum hyperemic response for both sex subgroups was significantly lower in the diabetic patients. The time to peak flow was higher in male diabetics. The half-time for hyperemia was significantly longer in the male diabetic patients. Cocnlusions: The females showed smaller changes in foot perfusion than the males, probably due to protection by estrogens. The best locations for perfusion measurement are the most distal, especially the hallex and the base of the little toe. The most valuable parameters of postocclusive hyperemia were maximum response, time to peak flow, and half-time of hyperemia.


    746/2523

    Tytuł oryginału: Mechanisms of knowledge learning and acquisition.
    Autorzy: Salamon Elliott
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.RA133-RA139, il., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The mechanism by which knowledge enters into memory has been a source of debate for some time. Theorists have proposed several models that aim at explaining the sequence of events from the perception of a stimulus, toits entrance into long-term storage. Much of this work was prompted by early research into the nuances of classical conditioning where it was first firmly established that organisms are capable of detecting covariations of stimuli within their environment. Subsequent work in the field has shown that these covariations form the basis for the mental representation of our surroundings, as well as the basis of learning. Work within the field of classical conditioning, along with the advance of computer technology and neuroscience has made these architectural models even more complex. Furthermore, experiments designed to support some of these proposed models have revealed that there are several conditions that can either aid or inhibit the transition of information into permanent storage. In this review we explore a number of these models, along with some classic critiques that have been levied against them. We also provide some history into the form of knowledge, termed 'implicit knowledge', as well as some of the proposed mechanisms of limplicit knowledge acquisition. We conclude by exploring the newly proposed theoretical framework within which implicit learning theory operates.


    747/2523

    Tytuł oryginału: The fragile histidine triad gene and breast cancer.
    Autorzy: Yang Qifeng, Yoshimura Goro, Sakurai Takeo, Kakudo Kennichi
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.RA140-RA144, bibliogr. 46 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: The Fragile Histidine Triad (FHIT) Gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a tumor suppressor gene involved in different tumor types. Abnormalities of the FHIT locus were found in many established cancer cell lines and tumors including breast cancer. In sporadic breast cancer, loss of heterozygosity within the FHIT gene has been observed at different frequencies and has been correlated with tumor progression. Aberrant FHIT transcripts have been reported in breast cancer. Furthermore, Fhit protein loss is correlated with prognosis. We summarized the research advances of FHIT genetic, epigenetic change and aberrant Fhit protein expression in breast cancer. Fhit protein may be a novel prognostic factor for breast cancer. FHIT gene therapy may potentially be clinically be clinically useful for treatment of breast cancer, suggesting further research involving FHIT introduction should be performed in breast cancer.


    748/2523

    Tytuł oryginału: TGF-á (transforming growth factor-á) in chronic inflammatory conditions - a new diagnostic and prognostic marker?
    Autorzy: Marek Andrzej, Brodzicki Jacek, Liberek Anna, Korzon Maria
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.RA145-RA151, il., bibliogr. 58 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: TGF-á is a cytokine with varied properties and pleiotropic activity. It is released in an inactive form. To exhibit its biological activity, it requires binding to extracellular matrix proteins and, after that, proteolytic elimination of LAP (Latent Associated Protein) and LTBP (Latent TGF-á Binding Protein). The process involves, among others, tissue transglutaminase, thrombin and plasmin. By stimulation of specific receptors, it influences transcription of some genes and translation of formed mRNA. Locally, it demonstrates proinflammatory properties whereas systemically, it has primarily a potent immunosuppressive effect. TGF-á, by affecting proliferation, differentiation and migration of cells, as well as stmulation of extracellular matrix protein production, plays an important role in tissue regeneration and remodeling, but also in fibrosis. TGF-á is also indispensable to maintain immune homeostasis of the organism. Reduced TGF-á activity is considered to be responsible for development of autoimmune disorders in the course of several pathologic conditions. This cytokine plays an important role in the pathogenesis of chronic inflammatory processes taking place, among others, in inflammatory bowel diseases (IBD) and chronic hepatitis B and C. The paper presents a review of literature concerning diagnostic and prognostic value of TGF-á level determinations in blood and tissue bioptates of patients with chronic non-specific enteritis and chronic hepatitis B and C.


    749/2523

    Tytuł oryginału: Pharmacogenomics.
    Autorzy: Tribut Olivier, Lessard Yvon, Reymann Jan-Michel, Allain Herv‚, Bentu‚-Ferrer DaniŠle
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.RA152-RA163, il., tab., bibliogr. 103 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Pharmacogenomics, a revolutionary chapter in the history of pharmacology, has received new impetus from the development and accessibility of molecular biotechnologies, notably DNA chips. The longstanding notion of responders/non-responders has given way to a more organic approach, where idiosyncrasy becomes an obsolete concept. This is a major step towards predictive, individualized medicine. In this review, several applications of pharmacogenomics are considered. Genetic polymorphisms of metabolization reactions, mainly with cytochrome P450, explain most of the cases described today. More fundamental and innovative studies have tried to link the structure of receptors or transporters and drug response. A leading topic in neuropsychopharmacology is the relation between the polymorphism of dopaminergic receptors and the efficacy of, or adverse reaction to, neuroleptics. In asthma, the structure of the á2-adrenergic receptor has been associated with response to treatment. Intrinsic genetic predisposition also plays an important role in cardiovascular diseases, and the role of ion channel mutations will be discussed. Research in oncological molecular epidemiology has explored the connection between the predisposition to certain cancers and specific enzymatic equipment hindering the detoxification of potentially carcinogenic exogenous compounds, or, on the contrary, promoting metabolic activation implicated in the formation of reactive compounds. The search for determinants of addictive behavior is another vast field of pharmacogenomics...


    750/2523

    Tytuł oryginału: Electron microscope investigation of the role of Chlamydia sp. in the process of rebuilding the arterial wall. Neoangiogenesis in atherosclerotic plaques in human cervical artery walls.
    Autorzy: Walski Michał, Łazowski Tomasz, Szosek Mieczysław, Opolski Grzegorz, Celary-Walska Renata, Andruszkiewicz Paweł, Ryba Mirosław
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR30-BR38, il., bibliogr. 40 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: The inflammatory process has an essential impact on the development of atherosclerosis. There mechanisms are mentioned.: 1) possibility of direct development of Chlamydia infection in the vicinity of the blood vessel wall; 2) impact of persistent or recurrent Chlamydia infection on the increased blood concentration of risk factors for atherosclerosis; 3) an autoimmunological reaction. Material/methods: Electron microscope examinations were performed on specimens from atherosclerotic lesions of the interior cervical arteries, collected from patients who had undergone endarterectomy. The material came from 8 patients (age from 58 to 72). The specimens were fixed for electron microscopy, and after dehydration were immersed in Spurr resin. Ultrathin slices were examined under a transmission electron micoroscope. Results: In the successive tested layers nearest the lumen of the vessel we found erythrocytic elements, fibrin, and lipid membranes. In deeper layers there were lymphocytic cells, monocytes, and macrophages loaded with phagocyted lipid material. Under this layer we found in some specimens a coating which had undergone mineralization: calcium structures and cholesterol were overlaid on a proteoglycanate base. Smooth muscles cells had undergone the heaviest proliferation among the cells on artery wall. In the tested material we detected diversified morphological forms of Chlamydia sp. Particular attetnion should be drawn to the appearance of very young vessel forms, which suggests a process of angiogenesis in the atherosclerotic plaques. Conclusions: We found that one of the pathogens that may lead ot atherosclerotic lesions is chalmydia wp. The process of atherogenesis in cervical arteries is accomanied by angiogenetic processes.


    751/2523

    Tytuł oryginału: Usefulness of immunohistochemical testing and electron microscopy in the diagnosis of embryonal rhabdomyosarcoma.
    Autorzy: Salwa-Żurawska Wiesława, Biczysko Wiesława, Woźniak Aldona, Janicka-Jedyńska Małgorzata, Trejster Ewa
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR39-BR46, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The article presents the results of histological, immunohistochemical, and ultrastructural examinations of embryonal rhabdomyosarcoma. Material/methods: 20 tumors were tested histologically, 13 immunohistochemically, and 5 under electron microscopy. Results: We found that in cases when the entire tumor or large specimens were obtained for estimation, it was possible by examining many areas of the neoplasm to establish a diagnosis on the basis of testing paraffined sections, routinely HE stained. Our evaluation of the value of certain additional histological methods indicated only slight diagnostic usefulness for tumors of this kind. Among the immunohistochemical methods we evaluated, the desmin assay had the greatest practical applicability, due to the fact that this antigen is also expressed in highly immature cells; in second place was myoglobin. Differences are pointed out in the results obtained by assaying myoglobin using DAB and the DAKO kit. Ultrastructural examinations revealed myofilaments of myosin and actin in all types of cells, including immature cells. Particular attention is drawn to the possibility of using material fixed in formalin for ultrastructural examination. The preservation of intact myofilaments in mateiral prepared in this way constitutes an essential diagnostic aid. Conclusions: In diagnosing embryonal rhabdomyosarcoma the most useful examination, apart from histological examination, is electron microscopy, followed by immunomorphological examination.


    752/2523

    Tytuł oryginału: Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese.
    Autorzy: Soma Masayoshi, Nakayama Tomohiro, Rahmutula Dolkun, Uwabo Jiro, Sato Mikano, Kunimoto Masako, Aoi Noriko, Kosuge Kotoko, Kanmatsuse Katsuo
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR1-CR4, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: The Dopamine D3 receptor (DRD3) gene is thought to be involved in essential hypertension (EH) because dopamine inhibits renin secretion via this receptor and because disruption of the DRD3 gene increases blood pressure in mice. EH is a complex, polygenetic disease. Association studies using the candidate gene approach may provide important clues regarding the etiology of hypertension and define a basis for further genetic investigation. Therefore we examined the association between the Ser9Gly polymorphism in the DRD3 gene and EH. Material/methods: One hundred eighty-one patients with EH and 181 age-matched subjects with normal blood pressure were enrolled. Genomic DNA was extracted from peripheral blood leukocytes. Polymerase chain reaction (PCR) was used to amplify the Ser9Gly polymorphic site in the DRD3 gene, and restriction fragment length polymorphism (RFLP) analysis of the PCR product was used to score the A and G alleles. Plasma renin acitvity and plasma aldosterone concentration were measured in untreated EH subjects. Results: The genotype distribution was in Hardy-Weinberg equilibrium, and was not significantly different between the NT and EH groups. The frequencies of A and G alleles were 0.674 (244/362) adn 0.326 (118/362) for the NT group and 0.688 (249/362) and 0.312 (113/362) for the EH group, respectively, and did not differ significantly between the two groups. The genotype did not influence the plasma renin activity and aldosterone concentration in untreated EH patients. Conclusions: The Ser9Gly polymorphism in the DRD3 gene are not associated with EH. However, our negative result does not exclude the possibility of another variant elsewhere in or near the DRD3 gene in EH.


    753/2523

    Tytuł oryginału: Effect of tissue injury on D-Dimer levels: a prospective study in trauma patients.
    Autorzy: Johna Samir, O'Callaghan Thomas, Cemaj Samuel, Catalano Richard
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR5-CR8, il., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: D-Dimer measurement has been used as a simple, non-invasive test to rule out thromboembolic phenomena in patients at risk for deep venous thrombosis (DVT) and/or pulmonary embolism (PE). Elevated D-Dimer level caused by tissue injury is believed to show a trend for gradual decrease to normal within the first three days after trauma. Material/methods: To study the effect of tissue injury on D-Dimer levels, we conducted a prospective measurement of D-Dimer levels in severely traumatized, high-risk patients for DVT or PE, starting within 24 hours after admission until disposition of the patient or to a total of 14 days of hospitalization. Patients were observed clinically for development of thromboembolic phenomena, and were subjected to weekly surveillance using duplex scan of teh lower exatremities. Additional testing was done if requested by the attending trauma surgeon. Results: A total of 21 patients wer enrolled in the study. There were 17 males, and 4 females. Patients had a mean age of (42) with a range of (17 - 79), and a mean ISS score of (20) with a range of (4 - 50). Seven patients completed 3 - 9 days of testing. Fourteen patients had more than 10 days of testing. Nine patients completed 14 days of testing. In all patients, tissue injury resulted in increased levels of D-Dimer above a threshold (500 ng/ml), below which DVT or PE can be ruled out. The increased levels failed to normalize even when testing was continued for 14 days. Conclusions: In our study, the increased D-Dimer levels induced by tissue injury failed to show a trend of gradual return to normal within...


    754/2523

    Tytuł oryginału: Activity of serum lipase [EC 3.1.1.3] and the diversity of serum lipid profile in psoriasis.
    Autorzy: Pietrzak Aldona, Lecewicz-Toruń Barbara
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR9-CR13, tab.,bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In the course of psoriasis the loss of scales from the skin surface is observed. This may be related to lipid disorders in epidermis and in blood serum. The aim of the study was to find out if serum lipid profile disturbances occur in psoriatic patients. Material/methods: We studied 26 male and 15 female normolipidemic psoriatic patients, and 29 male and 28 female healthy normolipidemic volunteers. The concentration of serum pancreatic lipase, total cholesterol, HDL cholesterol, LDL cholesterol, total phospholipids, HDL phospholipids, LDL phospholipids and triglycerides were measured with enzymatic methods. Results: The study of male patients demonstrated a statistically significant decrease in HDL cholesterol concentration and statistically signifcant increase in triglyceride concentration. In psoriatic females, we observed a statistically significant decrease in HDL cholesterol concentration, a statistically significant decrease in HDL phospholipid concentration, and a statistically significant increase in pancratic lipase concentration. In addition, the pancereatic lipase concentration increased insignificantly in the male group. We found lipid profile disturbances in the groups of psoriatic patients, in comparison with the age-, sex-, and BMI-matched control groups. Conclusions: The obtained results suggest the necessity of careful administration of medicines to psoriatic patients suffering from systsemic diseases and treated with drugs affecting lipid metabolism.


    755/2523

    Tytuł oryginału: An evaluation of the impact of supplementation with antioxidant vitamins on oxidation stress parameters in children with chronic recurrent gastroduodenitis.
    Autorzy: Bała Grażyna, Czerwionka-Szaflarska Mieczysława, Drewa Gerard, Mierzwa Grażyna
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR14-CR18, tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our research was to evaluate the impact of supplementation with antioxidative vitamins in children with chronic recurrent gastroduodenitis on the concentration of malondialdehyde (MDA) in plasma and erythrocytes, and on acitivity of the antioxidant enzymes: dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Material/methods: We studied 19 children (age from 13 to 16), diagnosed with chronic recurrent gastroduodenitis. The concentration of MDA was measured by Buege and Aust method, while the antioxidant enzyme activity was measured before and after a two-month course of supplementation with vitamins C and E: SOD by the Misra and Fridovich method, CAT by the Bears and Seizer method, and GSH-Px by the Paglia and Valentine method. Results: The average concentration of MDA in erythrocytes in the studied children was significantly higher (38.59 nM/gHb) than non control group (24.07 nM/gHb), but after supplementation was significantly reduced (p 0.05). The average SOD activity in the experimental group was significantly lower both before (885 U/gHb) and after supplementation (923.3 U/gHb) than in the control group (1240 U/gHb). The activity of the remaining enzymes did not differ significantly in experimental and control groups. Conclusions: The increased erythrocyte concentration of MDA in children with chronic recurrent gastroduodenitis may point to the generation of active forms of oxygen due to the low activity of the anti-oxidant enzyme SOD. Supplementation with the antioxidant vitamins C and E in children with a low antioxidant potenital and chronic recurrent gastroduodenitis reduces the generation of free oxygen radicals.


    756/2523

    Tytuł oryginału: Evaluation of bladder instability in children with recurrent urinary tract infections.
    Autorzy: Winiecka Wiesława, Zoch-Zwierz Walentyna, Wasilewska Anna, Wierciński Ryszard, Tomaszewska Barbara, Korzeniecka-Kozerska Agata, Porowski Tadeusz
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR19-CR23, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • urologia

    Typ dokumentu:
  • badanie porównawcze
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Impairment in the functions of the lower urinary tract can be the cause of recurrent urinary tract infections (UTI) and vesicoureteral reflux (VUR) in children. The purpose of our research was to evalute the frequency of occurrence of bladder instability in children with UTI. Material/methods: The research involved 114 children (21 boys, 93 girls), ranging in age from 5 to 16. Group I consisted of 61 children with a history of recurrent UTI, while Gorup II included 53 children with recurrent UTI and VUR. Urodynamic tests (uroflowmetry and cystometry) were done on all the children, while in selected cases profilometry was also performed, using a Duet apparatus (Dantec Medical A/S). Results: Abonrmal functioning of the lower urinary tract was found in 45 children (74 p.c.) from Group I and 44 children (84 p.c.) grom Gorup II. The most common dysfunction was instability of the detrusor muscle, which was found in 52 children (45 p.c.), including 23 (38 p.c.) from Group I and 29 (55 p.c.) from Group II. In 19 children detrusor instability was accompanied by reduced bladder volume, and in 8 cases there as a lack of detrusor-sphincter coordination. In both groups ca. 20 p.c. of the children did not present with symptoms indicating urination dysfunctions. Ca. 80 p.c. reported various symptoms, of which the most common were nocturnal wetting and urinary urgency. In half of the children from Group I and one-fourth of the children from Group II there were several co-occurring symptoms; nocturnal and diurnal wetting, pollakiruria, and urinary urgency, or all three symptoms simultaneously. Conclusions: The most common disturbance of lower urinary tract functioning in these children with recurrent UTI was instaability of the detrusor muscle, which occurred more often in children with VUR.


    757/2523

    Tytuł oryginału: Mathematical modelling in blood purification processes.
    Autorzy: Weryński Andrzej, Waniewski Jacek
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.69-84, il., bibliogr. 32 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The application of the one-dimensional theory of mass transport to the derivation of mathematical formulas for clearances of a variety of membrane mass exchangers, namely hemodialyzers, hemofilters, plasma separators, and the cascade filtration procedure, has been reviewed. The applied theory predicts that clearances depend approximately on fluid inlet rates but not no concentrations, and with constant fluid flow rates, clearances are constant. Also, the applications of device clearance in kinetic modelling has been discussed.


    758/2523

    Tytuł oryginału: Miniaturised semiconductor electrochemical biosensors.
    Autorzy: Torbicz Władysław, Pijanowska Dorota
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.85-98, bibliogr. 49 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: A review of own reserach works at the IBBE PAS on semiconductor biosensors of urea, glucose, pesticides, triglicerides and selected antigens in liquids, including biological fluids, on a background of the international state of art are presented in the paper. In the all above-mentioned biosensors, enzymatic reactions of substrate hydrolysis are used to receive the products, which detection would be possible by own construciton chemically sensitive transducers of the ISFET type. Methods of immobilisation of enzymes in different matrices are presnted. Parameters of these biosensors are given.


    759/2523

    Tytuł oryginału: Optical methods for tissue perfusion and oxygenation measurements.
    Autorzy: Maniewski Roman, Liebert Adam
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.99-112, il., bibliogr. 41 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Optical methods from the infrared range, especially Laser-Doppler flowmetry and near infrared spectroscopy offer a new non-invasive, real-time technique for monitoring of blood perfusion and oxygenation in living tissue. In spite of some instrumental problems e.g. relative calibration, unknown sampling measurement depth, these methods are already used in clincial studies. In the paper the methods principle, technical development and selected clinical applications have been described.


    760/2523

    Tytuł oryginału: Past and present of hall effect applications.
    Autorzy: Maniewski Roman, Zawicki Ignacy
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.113-128, il., bibliogr. 22 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The article presents the review of the Hall-effect applications in measurement technique, especially the research in this field carried out some time ago at the Institute of Biocybernetics and Biomedical Engineering PAS. The idea and constructions of many Hall-effect devices e.g. teslometers, electric power transducers, mechano-electric transducers for displacement and vibration measurements, seismograph and acceleration transducer are described in the article. Special attention was paid to biomedical applications of Hall-generators like mechanocardiograms and tremor recording as well as to the present status of the Hall-effect applications in measurements and automatic control.


    761/2523

    Tytuł oryginału: Tissue insulin sensitivity measurements in men. Quality factors and performance determinants for successful clamp experiments. Desing and development of the TISS system and its clinical verifications.
    Autorzy: Wójcicki Jan M., Ładyżyński Piotr, Foltyński Piotr, Mikulicz Hubert, Blachowicz Jacek
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.129-144, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Insulin sensitivity (IS) is one of the important diagnostic parameters used in treatments of diabetes, hypertension and other diseases as well as during evaluation of new drug therapies. Euglycaemic glucose clamp is the most accurate method of the IS measurement. Effectiveness of this procedure depends on accuracy of the tissue glucose utilization measurements (GU) and proper realization of the insulin infusion. Application of the accurate glucose control algorithm, sampling site, sampling frequency, duration of the procedure are also very important factors. Possible technical realization includes manual, semi-automatic and automatic modes. Recently the computerized semi-automatic system realizing this type of measurement has been designed and developed in the IBBE PAS. A developed system consist of control unit, infusion unit, glycaemia measurement unit and printer. Endogenous glucose secretion is suppressed by insulin infusion, which is determined according to individual patients parameters. The newest version of the measurement procedure allows to realize euglycaemic or normoglycaemic clamp studies. TISS system is inexpensive and easily operated by one person from middle medical staff. Till now GU measurements using TISS system were performed on over 200 patients in 4 Polish clincial centers. Developed and clinically tested TISS system seems to provide satisfying quality of the GU measurement in men.


    762/2523

    Tytuł oryginału: Cardiovascular, respiratory and veno-lymphatic assistance. Modelling and simulation.
    Autorzy: Górczyńska Krystyna, Darowski Marek, Kozarski Maciej
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.135-175, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In the paper some problems concerning investigations conducted at Bioflows Department of the Institute of Biocybernetics and Biomedical Engineering on cardiovascular, respiratory and veno-lymphatic assistance have been discussed. The investigations were mainly focused on modelling of cardiovascular and respiratory systems, cardiopulmonary interaction and veno-lymphatic non-invasive support. The results of physical and computer simulation of cardiopulmonary assistance and clinical results of veno-lymphatic support studies have been presented.


    763/2523

    Tytuł oryginału: From pattern recognition to image interpretation.
    Autorzy: Kulikowski Juliusz L.
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.177-197, il., bibliogr. 27 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In this paper selcted problems concerning computer-aided image processing in biomedical applications are described. The problems are related to a multi-year activity in this domain of the Department of Biomedical Information Processing Methods of the Institute of Biocybernetics and Biomedical Engineering PAS in Warsaw. In particular, an extension of the k-NN pattern recognition algorithm on the case of non-metric observation spaces is described. An example of a composite pattern recognition based on morphological parameters is presented. A concept of relations recognition as an extension of pattern recognition is also shortly described. In the last section some remarks concerning iamge interpretation methods have been given.


    764/2523

    Tytuł oryginału: Selecte problems in bionics.
    Autorzy: Zmysłowski Wojciech
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.199-206, bibliogr. 10 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Selected problems concerning the studies in the field of bionics have been reviewed. It have been shown that this discipline of science has an important impact on the development of studies in other disciplines and on the development of the innovative technologies. Particular attention was paid to the technical studies on information processing and control and biological studies on the mechanisms of physiological processes.


    765/2523

    Tytuł oryginału: Practical approaches to statistical pattern recognition.
    Autorzy: Jóźwik Adam
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.207-221, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The paper describes new approaches to statistical pattern recognition. All presented methods are based on a distance function. The properties of these methods and their usefulness are illustrated on real problems. Some tasks with small and very large training sets are described to shown and effectiveness of the proposed approaches. There is no one universal method that would be satisfactory for all object classification problems. That's why several methods have been demonstrated.


    766/2523

    Tytuł oryginału: Ranked designing of prognostic neural models for survival data.
    Autorzy: Bobrowski Leon, Krętowska Małgorzata
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.223-239, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The procedure of designing the non-linear dependencies of survival time on a family of covariates is described in the paper. This dependence is treated as a prognostic model. The first stage of this procedure involves designing such layers of formal neurons with are ranked with respect to selected subsets of censored data. The model based on the hierarchical networks of formal neurons results in the piecewise constant dependence of the survival time on the covariates. The replacement of the formal neurons results in the piecewise constant dependence of the survival time on the covariates. The replacement of the formal neurons by the logistic ones made it possible transform this dependence into differentiable, regression-type function.


    767/2523

    Tytuł oryginału: Monitoring pilot's eye movements during the combat flight - the white box.
    Autorzy: Ober Jan Krzysztof, Ober Jan Jakub, Malawski Marek, Skibniewski Wojciech, Przedpelska-Ober Elżbieta, Hryniewiecki Jerzy
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (2/3) s.241-264, il., bibliogr. 16 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Modern fighter pilots are often exposed to excessive accelerations. The resulting brain hipoxia can lead to G-LOC (G-induced loss of consciousness). Authors discuses the effects of microcirculatory adaptation released by the push-pull condition (rapid change from minus to plus Gz). The memory effect of vaso-constriction due to - Gz can be responsible for intermittent blocking of the compensatory vasodilatation and diminishing the +Gz tolerance of pilots tested on the centrifuge. Authors consider the push-pull condition to be analogous to the rapid blocking of the brain perfusion caused by the high plus Gz onset rates (1,G/s). Using the visual symptoms (narrowing of the visual field) is not longer adequate for monitoring the centrifuge push-pull training. Authors discuses the possibility of suing the saccadic eye movements as being the most adequate physiological signal to monitor the pilot's consciousness. Measuring pilots eye movements requires to develop a miniatrue complex motion transducer which can be used during centrifuge training as well as during the flight (the White Box). Problems encounterd during the system development are discussed.


    768/2523

    Tytuł oryginału: Evaluation of several methods used in anatomical investigations of the blood and lymphatic vessels.
    Autorzy: Jędrzejewski Kazimierz S., Cendrowska Ilona, Okraszewska Ewa
    Źródło: Folia Morphol. 2002: 61 (2) s.63-69, il., bibliogr. 15 poz.
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of this review is to describe the advantages and limitations of several methods used in anatomical investigations of intravisceral blood and lymphatic networks. The microangiographic methods as well as corrosion methods are described. In conclusion the authors as well as corrosion methods are described. In cocnlusion the authors confirmed that the most useful way for exploration of the blood and lymphatic vessels is to prepare corrosion casts. This paper focuses on the scanning electron microscopic examination of vascular corrosion casts. This method allows the examination of the three-dimensional organisation of vessels, including the blood and lymphatic capillaries. Imprints of endothelial cell nuclei can be observed on the surface of the blood and lymphatic vessels.


    769/2523

    Tytuł oryginału: Anatomical study of lumbar spine innervation.
    Autorzy: Higuchi Katsura, Sato Tatsuo
    Źródło: Folia Morphol. 2002: 61 (2) s.71-79, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: To precisely evaluate low back pain, identification of the detailed innervation of the lumbar spine is necessary. On twenty-five sides of adult cadavers we investigated various patterns of rami communicantes (RC) and their relationship to the psoas major muscle (PM). In ten sides, we focused our dissection on the minute nerve supply of the anterior (ALL) and posterior longitudinal ligaments (PLL), vertebral bodies and the intervertebral discs (IVD). According to the mode of piercing PM, two types of RC were observed: superficial oblique rami (SOR) and deep transverse rami (DTR). SOR ran obliquely between supreficial heads of PM, connecting sympathetic trunk (ST) and T12-l2 (3) spinal nerves non-segmentally. DTR ran segmentally close to the vertebral bodies and were situated deep to the pM slips. On the lateral side of the lumbar spine, the vertebral bodies and IVD received branches from DTR and ventral rami segmentally, as well as branches from the sympathetic trunk (ST) and, in the upper lumbar region, SOR non-segmentally. On the anterior aspect of the lumbar spine, ALL received branches from ST and splanchnic nerves non-segmentally. Within the vertebral canal, the posterior aspect of IVD and PLL received the sinu-vertebral nerves originating from DTR. These findings suggest the coexistence of two different types of innervation: one originating directly from the spinal nerve segmentally, and one reaching vertebral structures via the sympathetic nerves non-segmentally. Therefore, sympathetic nerves are likely involved in the proprioception of the spinal column.


    770/2523

    Tytuł oryginału: Vessels involved in the venous outflow from glandular mucosa of hamster stomach.
    Autorzy: Moskalewski Stanisław, Biernacka-Wawrzonek Dorota, Klimkiewicz Justyna, Zdun Rafał
    Źródło: Folia Morphol. 2002: 61 (2) s.81-87, il., bibliogr. 18 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki

    Streszczenie angielskie: Blood from the glandular part of hamster gastric mucosa is drained by collecting venules, running from the subepithelial layer towards lamina muscularis mucosae. To visualise vessels involved in the venous outflow, hamsters were exposed to atropine and subjected to intravital ligation of portal vein, causing strong hyperaemia. Distribution of vessels and their connections were studied a) in translucent, flat preparations of the glandular stomach, b) in thic sections of glandular mucosa cleared in the mineral oil, and c) in semi-thin plastic or parafin sections. Collecting venules were drained by single vessels running parallel to the lamina muscularis mucosae (paramuscular venules), which, in turn, joined submucosal veins through opening in muscularis mucosae. Moreover, some collecting and paramuscular venules discharged into venules belonging to vascular triples composed of two venules and arteriole. The triplets were also parallel to muscularis mucosae. Triplets did not form connections with submucosal veins but passed on the abluminal surface of muscularis mucosae. Thus, some structural elements involved in venous outflow from glandular gastric mucosa differ from those in rats, in which vascular triplets were absent and all collecting venules drained into single paramuscular vessels. Conctraction/relaxation of muscularis mucosae may regulat the amount of blood present in the venous system of the mucosa and the diameter of venules. Rhythmical changes of the latter could cause changes in intramucosal pressure, affecting movement of tissue fluid in the mucosa and thus the functio of gastric cells.


    771/2523

    Tytuł oryginału: Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain.
    Autorzy: Ludkiewicz Beata, Wójcik Sławomir, Spodnik Edyta, Domaradzka-Pytel Beata, Klejbor Ilona, Moryś Janusz
    Źródło: Folia Morphol. 2002: 61 (2) s.89-96, il., bibliogr. 42 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Immunohistochemical study of the cholinergic innervation of the parvalbumin- ad calbindin-containing cells in the hippocampus was conducted on 30 rat brains of various postnatal ages: PO, P4, P7, P14, P21, P30, P60 and P180. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and parvalbumin (PV) or calbindin (CB) were analysed using confocal laser-scanning microscope. Obtained data demonstrate that the pattern of cholinergic innervation of calbindin- and parvalbumin-immunoreactive hippocampal neurones shows some differences. During development as well as in the adult species cholinergic terminals preferentially innervate CB-containing neurones, while cholinergic terminals on PV-containing cells were observed rarely. Cholinergic endings on the CB-ir neurones are localised both on their somata and dendrities, whereas on PV-ir cells they form synaptic contact predominantly with processes. In spite of the unquestionable cholinergic influence particularly on CB-ir cells, the number of cholinergic endings suggests that this input seems not to be crucial for the activity of the studied cell populations.


    772/2523

    Tytuł oryginału: Preliminary study of external itneratrial muscle fascicles.
    Autorzy: Kozłowski Dariusz, Kamiński Rafał, Piwko Grzegorz, Gawrysiak Marcin, Owerczuk Adam, Piszczatowska Grażyna, Budrejko Szymon, Kozłowska Magdalena, Duda Barbara, Grzybiak Marek
    Źródło: Folia Morphol. 2002: 61 (2) s.97-101, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The atria are highly complex multidimensional structures composed of a heterogenous branching network of subendocardial muscular bundles. The relief of the inner part of the right atrium includes the crista terminalis as well as multiple pectinate muscles that bridge the thinner atrial free walls and appendages. However, a handful of studies have focused attention on the role of the naturally occurring complexities of the atrial subendocardial muscle structures in the mechanisms of cardiac arrhythmias. In accordance with the facts mentioned above, it was decided to examine the morphology and topography of the external interatrial junctions and related structures in order to define the possible anatomical basis of impulse propagation in focal atrial fibrillation. Research was conducted on material consisting of 15 human hearts of both sexes (female - 6, male - 9) from 18 to 82 years of age. In addition we were concerned, on the basis of the history and electrocardiograph tracings, that none of the patients had shown focal and non-focal type of atrial fibrillation. The classic macroscopic methods of anatomical evaluation were used. The walls of the atria were prepared via a stereoscopic microscope, the pericardium and fatty tissue were eliminated from the surface of the atria, visualising muscle fibres linking both of the atria, and the beginnings and the endpoints of fascicles in the right and left atrium were estimated. The structure, large muscle bundle, was present in all examined hearts. The muscle fascicle was descending from the anterior wall of the right atrium just below the orifice of the superior vena cava. The fascicle...


    773/2523

    Tytuł oryginału: Evaluation of extralaryngeal diameters in senile individuals.
    Autorzy: Zieliński Rafał, Jędrzejewski Kazimierz S.
    Źródło: Folia Morphol. 2002: 61 (2) s.103-106, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • badanie porównawcze
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was a morphometrical macroscopic evaluation of extralaryngeal diameters in elderly people, according to its usefulness in ORL diagnostic and operational methods. Laryngeal preparations together with surrounding structures were taken from cadavers of both sexes, aged 65 and over, about 24 hours after death. Clinically important extralaryngeal diameters were collected using common morphometrical methods. A few body features were also gathered. Computer statistical methods were used in data assessment including basic statistics and linear correlations between diameters, and between diameters and body features. The data presented in the study may be very helpful in diagnostic methods' evaluation. They may also help in: selection of the appropriate operational tool size, choice of the most appropriate operational technique, preoperative preparations and designing and building virtual models for physicians' training.


    774/2523

    Tytuł oryginału: Morphometric parameters of the human pineal gland in relation to age, body weight and height.
    Autorzy: Golan Janusz, Torres Kamil, Staśkiewicz Grzegorz J., Opielak Grzegorz, Maciejewski Ryszard
    Źródło: Folia Morphol. 2002: 61 (2) s.111-113, tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to compare the size, weight, volume and density of the pineal gland in several groups divided by age, body weight and height. 80 human pineal glands were included in the study. Obtained data were statistically analysed by means of Statistica by Statsoft to check existing differences. Obtained data show some significant differences between pineal gland morphometry in weight- and height-related groups. However, these differences do not influence pineal volume significantly. Differences between the pineal gland volume in the maximal and in the minimal weight groups may suggest some relationship between the gland's structure and body weight. No age-related changes in the morphometry of the pineal gland were observed.


    775/2523

    Tytuł oryginału: Distribution of various types of oligodendrocytes and cellular localisation of iron in the frontal cortex of the adult rat.
    Autorzy: Wawrzyniak-Gacek Agata
    Źródło: Folia Morphol. 2002: 61 (2) s.115-121, il., bibliogr. 36 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Oligodendrocytes, called oligodendroglia, are present in the white and grey substance of the CNS. They constitute a heterogeneous group, in which 3 types of these cells have been distinguished: those of light, medium and dark cytoplasm. They locate themselves at the neurones and blood vessels. The number of light oligodendrocytes decrease with age, while the number of dark oligodendrocytes increase. In histochemical studies the product of the reaction located itself in the body and processes, indicating the participation of these cells in the metabolism of iron.


    776/2523

    Tytuł oryginału: Prenatal development of the human trachea.
    Autorzy: Adamiec Ewa, Dzięciołowska-Baran Edyta, Czerwiński Florian, Miklaszewska Danuta, Teul Iwona
    Źródło: Folia Morphol. 2002: 61 (2) s.123-125, il., bibliogr. 8 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The tracheas of 46 human foetuses were examined: 26 male, 20 female with C-R length of 99-255 mm. The analysis of the total length of the trachea was carried out and its transverse dimension was presented on three levels: on the first tracheal cartilage, in the mid-length of the trachea, and at the bifurcation into the main bronchi; also the proportions between these dimensions and the C-R length were analysed. The length of the trachea was measured in a sraight line - from the end of larynx to the bifurcation of the trachea. Comparing tracheas to a tunnel with two openings, it was observed that the transverse dimension, the "laryngeal", is greater than the "bronchial" - in the case of smaller foetuses by 2 mm, but in foetuses with C-R length of over 250 mm by 1 mm. Moreover, no signficant differences between male and female sex were noticed. All the measurements were taken with the use of a slide caliper. The results should be useful in the detection of abnormalities in the structure of the trachea, in problems with respiratory physiology and in endotracheal intubation, endoscopy or tracheostomy.


    777/2523

    Tytuł oryginału: Die Schallverarbeitung in der Cochlea.
    Tytuł polski: Przetwarzanie dźwięku w ślimaku.
    Autorzy: Zenner Hans-Peter
    Źródło: Otolaryngol. Pol. 2002: 56 (6) s.657-660, il., bibliogr. 30 poz., streszcz.
    Sygnatura GBL: 313,466

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: Na podstawie danych z piśmiennictwa oraz własnych autora badań i doświadczeń w pierwszej części pracy w sposób poglądowy, prosto i przekonująco zostały przedsatwione zjawiska transdukcji i transformacji zachodzące w ślimaku pod wpływem stymulacji dźwiękowej. W drugiej części pracy natomiast opisano specyfikę częstotliwościową ślimaka wyjaśniającą podstawy zrozumiałości mowy i odbioru muzyki. Podstawy teorii fali wędrującej laureata nagrody Nobla Bekesego (którego, jak podkreśla autor, swego czasu wyganano z Niemiec) zostały uzupełnione ostatnimi odkryciami w zakresie czynności komórek słuchowych zewnętrznych jako wzmacniacza bodźców docierających do komórek słuchowych wewnętrznych.


    778/2523

    Tytuł oryginału: Mycosis fungoides of the larynx: case report and review of the literature.
    Tytuł polski: Mycosis fungoides krtani: opis przypadku oraz przegląd piśmiennictwa.
    Autorzy: Lippert B. M., H”ft S., Teymoortash A., Wiedow O., R”vert J., Werner J. A.
    Źródło: Otolaryngol. Pol. 2002: 56 (6) s.661-667, il., tab., bibliogr. 31 poz., streszcz.
    Sygnatura GBL: 313,466

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Mycosis fungoides jest rzadką postacią chłoniaka skóry. Uogólnienie procesu chorobowego na okolicę skóry zewnętrznej powoduje, że choroba ta należy do schorzeń o poważnym przebiegu. Objawy choroby umiejscowione w krtani są tylko w 13 przypadkach przedstawione w literaturze dostępnej. W pracy przedstawiono przypadek mycosis fungoides krtani o terminalnym zaawansowaniu schrzenia, dodatkowo zajmujacym zatokę szczękową lewą. Przedstawiono również zestawienie opublikowanych do chwili obecnej przypadków. W ocenie autorów praca przedstawia pierwszy przypadek lokalizacji mycosis fungoides obejmującą krtań oraz zatoki przynosowe. W podsumowaniu zaznaczono, że na podstawie przyadku własnego oraz danych pochodzących z dostępnej literatury wskazane jest w tych przypadkach stosowanie leczenia paliatywnego, aby uzyskać jak najlepszą jakość życia u chorych.


    779/2523

    Tytuł oryginału: Lipoma of the larynx. Report of 2 cases and review of the literature.
    Tytuł polski: Tłuszczak kratni. Opis dwóch przypadków oraz przegląd piśmiennictwa.
    Autorzy: Lippert B. M., Eggers S., Schlter E., Rudert H., Werner J. A.
    Źródło: Otolaryngol. Pol. 2002: 56 (6) s.669-674, il., bibliogr. 31 poz., streszcz.
    Sygnatura GBL: 313,466

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie polskie: Tłuszczaki jako pierwotne guzy mezenchymalne występują bardzo rzadko w gardle dolnym i krtani, często w badaniu makroskopowym przypominają torbiele retencyjne. W piśmiennictwie opisano 112 przypadków. Przedstawiono 2 przypadki tłuszczaków krtani, które usnięto endoskopowo oraz z dojścia zewnętrznego. Nie zaobserwowano wznów miejscowych.


    780/2523

    Tytuł oryginału: Investigation of the serological reactivity of the antibodies produced against Citrobacter braakii 037 with human and horse erythrocytes : doctorate thesis
    Autorzy: Ebaid Hossam
    Opracowanie edytorskie: Gamian Andrzej (supervis.).; Polish Academy of Science Institute of Immunology and Experimental Therapy, Laboratory of Medical Microbiology in Wrocław
    Źródło: 2002, [2], 141 k. : il., tab., bibliogr. k. 122-141, sum., maszyn.
    Sygnatura GBL: 45/19658

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca doktorska
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    781/2523

    Tytuł oryginału: Linear IgA bullous dermatosis in a diabetic patient with chronic renal failure.
    Autorzy: Serwin Agnieszka Beata, Myśliwiec Hanna, Laudańska Halina, Chodynicka Bożena
    Źródło: Int. J. Dermatol. 2002: 41 (11) s.778-780, il., bibliogr. 11 poz.
    Sygnatura GBL: 305,645

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • dermatologia i wenerologia
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: A 60-year-old woman was admitted in October 2000 for disseminated polymorphic papular and vesiculobullous skin lesions with a herpetiform pattern. The eruption occurred 1 month prior to admission and was accompanied by intense itching and burning. A few vesicles in the oral mucosa appeared 6 months after the onset of the skin lesions. The patient's history was notable for noninsulin-dependent diabetes mellitus since the age of 32 years, complicated by arterial hypertension, neuropathy, and nephropathy with subsequent renal failure. The patient started hemodialysis 20 years after the onset of diabetes and was hemodialyzed three times a week for 4 h (index of dialysis adequacy (Kt/v) - 1.3). She had received insulin since the age of 55 years. Furosemide, started in 1998, was withdrawn in October 2000, a few days after admission. Histopathologic examination of the skin lesions revealed subepidermal blisters with an infiltrate of polymorphonuclear cells within the timps of dermal papillae. A diagnosis of linear immunoglobulin A (IgA) bullous dermatosis was confirmed by direct immunofluorescence assay of perilesional skin showing linear IgA (++) and IgG (+) deposits within the basement membrane zone. No antiepidermal basement membrane zone or antiendomysial IgA antibodies were detected in the patient's serum. Abnormal laboratory values were as follows: hemoglobin concentration, 10.6 g/dL; red blood cell count, 3.1 x 10**6 ćL; platelets, 99.0 x 10**3/ćL; glucose concentration, 228.0 mg/dL; creatinine concentration, 5.3 mg/dL; glycosuria and proteinuria...


    782/2523

    Tytuł oryginału: Formalin-induced pain and ć-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice.
    Autorzy: Borghi Valentina, Przewłocka Barbara, Labuz Dominika, Maj Marcin, Ilona Obara, Pavone Flaminia
    Źródło: Brain Res. 2002: 956 (2) s.339-348, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 312,085

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The effects of adenosine analogues on pain have been shown to depend on the subtype receptor involved as well as on the nociceptive stimuli and on the route of administration. In the first exeperiment of the present study intraperitoneal administration of the A1 receptor agonist N**6-cyclopentyladenosine (CPA) (0.015, 0.03, 0.09, 0.15, 0.21, 0.3 mg/kg) induced dose -dependent analgesia to formalin pain in both phases characterizing the test. The A2a receptor agonist 2-[p]2-(carbonyl-ethyl)-phenyethylamino]-5'-N-ethylcarboxaminoadenosine (CGS21680) (0.025, 0.05, 0.1, 0.15 mg/kg) significantly affected behavioral responses to formalin only during the early phase. In the second experiment the interaction between adenosine and the opioid system was investigated through both behavioral and neurochemical studies. The opioid antagonist naltrexone (0.1 mg/kg) did not affect the antinociception induced by CPA (0.21 mg/kg) and CGS21680 (0.05 mg/kg). Autoradiographic studies showed that formalin administration significantly modified ć-opioid receptor density in the superficial laminae of the spinal cord and in the paracentral thalamic nucleus, contralateral to the side of formalin injection. CPA and CGS21680 counteracted these effects induced by formalin. In conclusion the present study confirms and extends the role of A1 and A2a adenosine receptors in the modulation of inflammatory pain and their interaction with the ć-opioid system, and suggests further invetigation of these purinergic receptors from a therapeutic perspective.


    783/2523

    Tytuł oryginału: Environmental manipulation differentially alters c-Fos expression in amygdaloid nuclei following aversive conditioning.
    Autorzy: Nikolaev Evgeni, Kaczmarek Leszek, Zhu Shun Wei, Winblad Bengt, Mohammed Abdul H.
    Źródło: Brain Res. 2002: 957 (1) s.91-98, il., bibliogr. 50 poz.
    Sygnatura GBL: 312,085

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: This study analyzes the impact of environmental complexity in adult rats on their emotional behavior and c-Fos expression (a transcription factor protein implicated in neuronal plasticity) in various subdivisions of amygdala, as well as selected parts of the thalamus and hypothalamus. The animals were housed for 60 days in either enriched or impoverished conditions and then one group of rats was tested in an open field test, and a second group of rats was treated to footshock-motivated aversive training. Two and 24 h later, the animals from the second group, along with the appropriate controls, were sacrificed and their brains were used for the immunocytochemical analysis of c-Fos levels. We found that this long-term environmental manipulation exerts significant effects on animals' emotionality and this behavioral diference is accompanied by the differential c-Fos activation (at 2 h after the aversive training) in the amygdala, a brain structure believed to subserve emotional reactions. On the other hand, no difference was found in c-Fos expression between both groups of animals in the thalamus and hypothalamus. At 24 h after the training, c-Fos levels were down to the values observed in naive rats that did not differentiate between enriched versus impoverished breeding conditions. These results may help to explain differential emotional aspects of behavior that arise following differential housing conditions of adult animals.


    784/2523

    Tytuł oryginału: Cross-tolerance between the different ć-opioid receptor agonists endomorphin-1, endomorphin-2 and morphine at the spinal level in the rat.
    Autorzy: Labuz D., Przewłocki R[oman], Przewłocka B[arbara]
    Źródło: Neurosci. Lett. 2002: 334 (2) s.127-130, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: In the present study we investigated the development of tolerance to an antinociceptive effect after intrathecal administration of endomorphin-1, endomorphin-2 and morphine in tail-flick and paw pressure tests. We also assessed crosstolerance between the antinociceptive effects of the two endogenous ć-opioid receptor agonists - endomorphins and morphine. The tolerance developed on day 3 after i.th. injection of both endomorphins, endomorphin-2 (18, 36 nmol), endomorphin-1 (16 nmol). After morphine (30 nmol) the tolerance developed on day 6. Our study described the crosstolerance between morphine and endomorphin-1, but not endomorphin-2. In comparison with naive rats, morphine had a weaker antinociceptive effect in rats tolerant to endomorphin-1. In contrast, no cross-tolerance was observed after administration of endomorphin-2 in rats tolerant to endomorphin-1. In rats tolerant to endomorphin-2, the antinociceptive effect of morphine and endomorphin-1 was attenuated in both the tests used. Our results suggest that the three lignds of ć-opioid receptors probably act via different subtypes of the ć-opioid receptor.


    785/2523

    Tytuł oryginału: Trace elements distribution in renal cell carcinoma depending on stage of disease.
    Autorzy: Dobrowolski Zygmunt, Drewniak Tomasz, Kwiatek Wojciech, Jakubik Piotr
    Źródło: Eur. Urol. 2002: 42 (5) s.475-480, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 312,572

    Hasła klasyfikacyjne GBL:
  • onkologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Objectives: The aim of this study was to identify those trace elements which can be used to distinguish between normal and malignant tissue in renal cell cancer (RCC) kidney and to assess changes in trace elements concentration in tissue with progressing malignant disease. Methods: In case control study, 36 cases of RCC were analyzed by Synchrotron Radiation Induced X-ray Emission (SRIXE) in order to establish the concentration of 19 elements. Patients with RCC were examined to obtain staging of disease after radical nephrectomy, which was performed in each case. Results were compared with 15 control kidney cortex tissue obtained during autopsy in which cause of death was trauma. Results: The most relevant decrease was detected in Cd content: from 81 ń 39.2 ppm in normal control samples to 16.6 ń 22.2 ppm concentration in RCC. We found that the concentrations of Ti, Pb and Rb were also lower in RCC tissue. On the other hand, the RCC tissue was rich in iron and zirconium. With the progress of malignant disease, assessed by TNM (UICC 1997) scale, lower concentration of S and higher concentration of Ca in both RCC and neoplastic kidney cortex can be seen. The same tendency is observed in Zn and Se concentrations. Cadmium shows raising concentration with progress of RCC only in cortex of neoplastic kidney. In all cases it was shown that the relatively high tissue concentration of iron in both investigated tissues is decreasing with the progress of disese. The zirconium has shown raising tissue concentration in advanced disease...


    786/2523

    Tytuł oryginału: Retroperitoneoscopic nephrectomy in the prone position in children (point of technique).
    Autorzy: Urbanowicz Wiesław, Wieczorek Maria, Sulisławski Janusz
    Źródło: Eur. Urol. 2002: 42 (5) s.516-519, il., bibliogr. 15 poz.
    Sygnatura GBL: 312,572

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: We describe our initial experience with retroperitoneoscopic procedures in children in the prone position. Twelve children (five girls and seven boys; mean age 3.5 years) underwent nephrectomy, nephroureterectomy or heminephrouretectomy for obstruction or reflux within the non-functioning kidney, multicystic dysplastic kidney or upper pole dysplastic moiety. None of the operations were converted to an open procedure. The mean operative time for these procedures was 110 minutes. Blood loss was less than 20 ml.


    787/2523

    Tytuł oryginału: Immediate hypersensitivity in bullous pemphigoid. A review of our own data and the literature.
    Tytuł polski: Nadwrażliwość natychmiastowa w pemfigoidzie pęcherzowym. Przegląd danych własnych i piśmiennictwa.
    Autorzy: Bowszyc-Dmochowska Monika, Dmochowski Marian
    Źródło: Post. Dermatol. Alergol. 2002: 19 (1) s.7-16, il., bibliogr. 139 poz., streszcz.
    Sygnatura GBL: 313,632

    Hasła klasyfikacyjne GBL:
  • immunologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy przedstawiono zjawiska nadwrażliwości natychmiastowej w pemfigoidzie pęcherzowym (BP). Eozynofile są istotne w patogenezie ludzkiego PB. Pobudzenie tych komórek w BP może prowadzić nie tylko do uszkodzenia tkanki, ale może najprawdopodbniej także być elementem regulacji odpowiedzi immunologicznej w tej chorobie. Pobudzenie komórek Th2 stymuluje produkcję autoprzeciwciał IgG4 i IgE przeciwko białkom półdesmosomalnym, antygenowi BP o masie 180 kDa i antygenowi BP o masie 230 kDa.


    788/2523

    Tytuł oryginału: Relationship between body composition, sex hormones and leptinemia in hemodialyzed patients with chronic renal failure.
    Autorzy: Chudek J., Adamczak M., Kokot F[ranciszek], Karkoszka H., Ignacy W., Klimek D., Więcek A.
    Źródło: Clin. Nephrol. 2002: 58 (6) s.431-437, il., tab., bibliogr. [37] poz.
    Sygnatura GBL: 312,466

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Female are characterized by significantly higher plasma leptin concentration than males. It seems likely that sex hormones influence leptinemia independently from differences in body composition. The aim of the present study was to analyze the contribution of plasma concentrations of testosterone and estradiol on leptinemia in hemodialyzed patients. Methods: 110 hemodialyzed patient - HD (60 M. 50 F) and 70 healthy subjects (HS) (30 M, 40 F) were enrolled in this study. Plasma leptin, testosterone or estradiol and CRP concentrations and body composition by dual-energy X-ray absorptiometry (DEXA) were assessed. Results: Total body fat was significantly higher in femals than in males (27.5 ń 1.5 p.c. vs. 17.2 ń 1.0 p.c. of body weight in HD and 36.0 ń 1.0 p.c. vs. 18.2 ń 1.4 p.c. in HS, respectively). Plasma leptin concentrations were markedly higher in females than in mals both in HD (27.9 ń 5.4 ng/ml vs. 9.6 ń 1.9 ng/ml) and HS (16.5 ń 1.7 ng/ml vs. 3.1 ń 0.4 ng/ml). A highly significant, strong positive correlation was found between total fat mass (TFM) and leptinemia in all studied groups. No significant univaried correlation between plasma leptin and testosterone or estradiol concentrations respectively was found both in HD and HS. Multiple regerssion analyses showed that the main determinant of leptinemia is TFM (á = 0.623 and 0.798 in HS females and males respectively, and á = 1.058 and 0.797 in HD females and males respectively). Plasma concentration of testosterone (á = -0.139 and á = - 0.075 in male HD and HS respectively)...


    789/2523

    Tytuł oryginału: Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty.
    Autorzy: Poloński Lech, Dec Iwona, Wojnar Rafał, Wilczek Krzysztof
    Źródło: Curr. Med. Res. Opin. 2002: 18 (7) s.389-396, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 305,759

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: This open-label, randomised, controlled study is aimed at assessing the effect of pre-treatment with the metabolic agent trimetazidine on the degree of ischaemia during percutaneous transluminal coronary angioplastry (PTCA). Overall 44 patients with one-vessel coronary artery stenosis ( 70 p.c.) in the medial part of the left anterior descending artery were included. One group (n = 22) was pre-treated with oral trimetazidine. The other group (n = 22) was the control. All patients (n = 44) were administered aspirin and conventional treatment. All patients underwent PTCA; stents were implanted in 11 trimetazidine patients and in seven control patients. The mean ST-segment elevation during all balloon inflations was significantly lower in the trimetazidine group than in the control group (-1.66 ń 1.50 mm vs. 3.29 ń 1.59 mm, p = 0.001). Maximal ST-segment elevations and mean ST elevation values during sequential balloon inflations were also significantly lower weith trimetazidine (p = 0.018). The mean amplitude of the T-wave alterations during all ballon inflations was significantly lower with trimetazidine (3.09 ń 2.39 mm vs. 6.83 ń 4.31 mm; p = 0.001). Similary, the maximal amplitude of the T-wave alterations was 4.50 ń 2.90 mm with trimetazidine vs. 9.25 ń 4.97 mm in control patients (p = 0.0005). Angina and rhythm disturbances were more frequent in the control group. Time from balloon inflation to onset of angina was 50 ń 26.2 s with trimetazidine vs. 32 ń 15.0 s, for control group (p = 0.03). The time to pain relief after deflation was 19.3 ń 11.4 s with trimetazidine vs. 28.2 ń 16.8 s (p = 0.001)...


    790/2523

    Tytuł oryginału: Limb lengthening in automatic mode.
    Tytuł polski: Wydłużanie kończyn metodą automatyczną.
    Autorzy: Ivanovich Shevtsov Vladimir, Vasilyevich Popkow Arnold
    Źródło: Ortop. Traumatol. Rehabil. 2002: 4 (4) s.403-412, il., tab., bibliogr. 28 poz., sum.
    Sygnatura GBL: 313,531

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.

    Streszczenie polskie: Wstęp. W ośrodku naukowym im. Ilizarowa w Rosji wykonano ponad 5000 zabiegów wydłużenia kości kończyn górnych i dolnych, w tym 406 odcinków wydłużonych w systemie automatycznym. Rozciąganie wykonywano całodobowo, w tempie 1 mm na 60 cykli operacyjnych aparatu samorozciągającego. Materiał i metoda. Wydłużanie w trybie automatycznym wykonano u 171 pacjentów w wieku od 5 do 43 lat. Zastosowano techniki jednoodcinkowe i wieloodcinkowe. Długość wydłużenia kończyn mieściła się w przedziale od 3 do 16 cm. Średnia wartość wydłużenia za pomocą metody osteosyntezy jednoodcinkowej wynosiła 6,1 ń 2,0 cm, natomiast za pomocą metod wieloodcinkowych - 7,2 ń 1,5 cm. Mierzono również siły rozciągania rozwinięte w aparacie samorozciągającym. W celu opracowania obiektywnej oceny zalet dystrakcji metodą automatyczną obliczyliśmy współczynnik stabilizacji w aparacie samorozciągającym na jeden centymetr wydłużenia. Wyniki i wnioski. Współczynnik stabilizacji wynosił tylko 5-6 dni na 1 cm, przy użyciu techniki automatycznego rozciągania, natomiast za pomocą ręcznej regulacji wydłużania, aż 22-24 dni na 1 cm. W badaniach biochemicznych metabolizmu kostnego, podczas wydłużenia, wykazano mierzalną aktywność takich enzymów krwi, jak np. fosfotazy zasadowe i kwaśne, jak również duże ilości minerałów w obrębie zachodzącej osteogenezy związanej z rozciąganiem.


    791/2523

    Tytuł oryginału: TRAIL induces death of human oligodendrocytes isolated from adult brain.
    Autorzy: Matysiak Mariola, Jurewicz Anna, Jaskólski Dariusz, Selmaj Krzysztof
    Źródło: Brain 2002: 125 (11) s.2469-2480, il., bibliogr. [41] poz.
    Sygnatura GBL: 300,909

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce apoptosis in various tumour cell lines and, recently, also in normal cells. TRAIL interacts with four receptors: two signalling receptors (TRAIL-R3 and TRAIL-R4). We have shown that both signalling receptors are present on the surface of oligodendrocytes isolated from adult human brain (ahOL), whereas the decoy receptors are expressed at a low level on ahOL. TRAIL induces ahOL apoptosis - as charcterized by Annexin V staining prior to propidium ioddide cell uptake - under conditions of protein synthesis inhibition. However, pretreatment of ahOL with interferon ç (IFNç) evoked susceptibility to TRAIL-induced death, which did not require inhibition of protein synthesis. A blocking experiment with monoclonal antibodies directed gainst TRAIL-R1 and TRAIL-R2 revealed that TRAIL-R1 is mainly involved in TRAIL-induced apoptosis of ahOL. In contrast to ahOL, microglial cells were completely resistant to cell death induced by TRAIL. Microglial cells had high surface expression of the decoy receptor TRAIL-R3, suggesting that resistance of these glial cells to TRAIL-induced death depends onthe presence of the protective effect of TRAIL-R3. Stimulation of microglia with TRAIL increased further expression of TRAIL-R3, but it had no effect on the expression of TRAIL receptors by ahOL. This result may implicate TRAIL as an effector-immune molecule in selective ahOL demise in inflammatory/demyelinating conditions.


    792/2523

    Tytuł oryginału: Polish consensus: procedure in case of estrogen deficiency in women after breast cancer therapy.
    Autorzy: Milewicz A., Szymański W., Rużyłło W., Zgliczyński S[tefan], Reinfus M., Zieliński J., Dębski R., Demissie M., Tworowska U.
    Źródło: Gynecol. Endocrinol. 2002: 16 (5) s.385-389, bibliogr. 30 poz.
    Sygnatura GBL: 313,072

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • endokrynologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Women surviving breast cancer in the postmenopausal period suffer from hormonal alternations with adverse effect on mental status and functioning of a number of organs and systems. Two thirds of these women had menopause before the diagnosis of breast cancer. In the remaining one-third ovarian failure is natural or induced by chemotherapy. Doctors cautiously approach the use of estrogen therapy in this group of patients. Their fears are not unsupported bearing in mind known epidemiological data exist linking breast cancer with the use of hormonal therapy. The purpose of this review is to evaluate current data on hormonal use and breast cancer risk.


    793/2523

    Tytuł oryginału: L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II.
    Autorzy: Fedosiewicz-Wasiluk Małgorzata, Hoły Zdzisław Z., Wiśniewski Konstanty
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.415-422, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The study was designed to investigate the role of the activation of class III metabotropic glutamate receptors (mGluRs) in the behavioral activity of angiotensin II (AngII). The experiments were performed on adult male Wistar rats. Stimulation of group III mGluRs was evoked by icv injection of agonist, L-2-amino-4-phosphonobutyric acid (L-AP4) (5 ćl of 80 mM solution of L-AP4). Fifteen minutes later, the animals were given icv solution containing 1 nmol of AngII. Memory motivated affectively was evaluated by passive avoidance and active avoidance responses (CARs). Moreover, the speculative influence of the treatment on motor activity was tested in open field. We observed that both compounds did not have significant influence on motor activity of rats in open field tesrt. L-AP4 given alone had no influence on acquisition, consolidation and recall of passive avoidance responses. Examination of influence of L-AP4 on the acquisition of CARs, while it did not alter extinction of these responses. AngII, as repeatedly shown before, greatly increased passive avoidance latency, rate of acquisition of CARs and decreased they extinction. Pretreatment of rats with L-AP4 prevented all above behavioral effects of the AngII administration.


    794/2523

    Tytuł oryginału: Muscimol changes hypoxia-induced imapirment of behavior in rats.
    Autorzy: Oksztel Robert, Car Halina, Wiśniewski Konstanty
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.423-431, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Muscimol, a seleactive agonist of GABA-A receptors, causes changes in behavioral activity. Hypoxia interferes with the GABAergic system and with the functions of GABA-A receptors. We used muscimol in Wistar rats to extimate its influence on locomotor activity in the open field test as well as on the processes of consolidation and retrieval, evaluated in the test of passive conditioned reflexes. Anxiolytic activity was examined in the elevated "plus" maze in physiological state and after hypoxia-induced amnesia. Following intraperitoneal administration of muscimol (1 mg/kg, ip), the animals showed a decrease in motility, in retrieval of skill reflexes and in a number of entries into open and closed arms in the elevated plus "maze". In animals exposed to hypoxia, we observed reduced motility in the open field, inhibition of retrieval and consolidation of passive conditioned reflexes, shortened time of sojourn in open arms and decreased number of entries into open and closed arms. In the goroup of animals which underwent hypoxia and then received muscimol, we observed no effect of hypoxia on muscimol activity in the open field test, except rearing when muscimol action was significantly reduced. Muscimol improved consolidation but not retrieval in comparison with the hypoxic saline-treated group of rats. In the elevated "plus" maze test, treatment of rats with muscimol after hypoxia significantly prolonged the time spent in open arms and increased the number of entries into open arms, while shortened the time spent in closed arms. In conclusion, muscimol in hypoxia-exposed group of rats exerted beneficial effect on consolidation in passive avoidance situation and exerted anxiolytic activity. Changes in the activity of muscimol under hypoxia may have significant clinical implications.


    795/2523

    Tytuł oryginału: Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1.
    Autorzy: Chłopicki Stefan, Bartuś Joanna B., Gryglewski Ryszard J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.433-441, il., bibliogr. 49 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Recent evidence suggests that hypoxic pulmonary vasoconstriction (HPV) is mediated by hypoxia-induced closure of voltage-gated potassium channels in pulmonary vascular smooth muscle cells. It is also claimed that various vasoconstrictor mediators such as thromboxane A2 (TXA1), platelet activating factor (PAF), cysteinyl leukotrienes (cys-LTs) or endothelin-1 (ET-1) contribute to HPV. Their role, however, has not been unequivocally accepted. On the contrary, it is well known that endothelium-derived nitric oxide negatively modulates HPV. Since NO counteracts action of vasoconstrictor mediators, we tested the hypothesis that modulatory role of TXA2, PAF, cys-LTs and ET-1 in HPV would become apparent in absence of endogenous NO. For that purpose we assessed contribution of these mediators to HPV in the isolated blood-perfused rat lung pretreated with a nonselective NOS inhibitor, L-NAME. HPV, which was greatly augmented by L-NAME (300 ćM) alone, was inhibited neither by a TXA2 synthase inhibitor (Camonagrel, 300 ćM), nor by a PAF receptor antagonist (WEB 2170, 100 ćM), nor by an inhibitor of five-lipoxygenase-activating protein (MK 886, 10 ćM), nor by a non-selective ET-1 receptor antagonist (LU 302872, 30 ćM). In summary, in isolated blood-perfused rat lung, TXA2, PAF, cys-LTs and ET-1 seem not to be involved in HPV, whereas we confirm the dominant role of endogenous NO in blunting HPV.


    796/2523

    Tytuł oryginału: Mechanisms of delayed preconditioning with A1 adenosine receptor activation in porcine coronary smooth muscle cells.
    Autorzy: Neyeem Mohammed A., Mustafa S. Jamal
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.443-453, il., bibliogr. 49 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie angielskie: This study examined the hypothesis that the activation of A1 adenosine receptor (A1AR) induces delayed cellular protection (DCP) in porcine coronary smooth muscle cells (PCSMC). The following groups of cultured PCSMC, subjected to simulated ischemia (SI) at 20 h were studied: (a) SI: with ischemia alone; (b) A1AR agonist chloro-N6-cyclopentyl adenosine (CCPA: CCPA (1 ćM) alone; (c) CCPA + PKC inhibitor chelerythrine chloride (CCL): CCPA and 1 ćM CCL; (d) CCPA + iNOS inhibitor S-methylthiourea (SMT): CCPA and 100 nM SMT; (e) CCPA + KATP channel blocker Glibaenclamide (Glb): CCPA adn 50 ćM Glb; (f) CCPA + mitochondrial KATP channel blocker 5-hydroxydecanoate (5-HD): CCPA and 100 ćM of 5-HD; (g) CCPA + A1AR antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX): CCPA and 1ćM DPCPX. The release of LDH into the medium as well as the amount of LDH remaining in the cells was used as a marker of cellular injury and cell viability. Up-regulation of A1AR, î-PKC, iNOS and HSP 72i was detected through Western blot analysis. The cellular resistance (LDH remaining in the cells) acquired by PCSMC due to CCPA (59.42 ń 1.57) was significantly blocked by CCL; 39.30 ń 2.03; SMT: 41.37 ń 1.98; Glb: 47.24 ń 1.31; 5-HD: 47.69 ń 1.40 and DPCPX: 42.92 ń 0.79. CCPA increased the expression of A1AR (1.30 fold), î-PKC (1.20 fold), iNOS (1.50 fold), and HSP 72i (1.70 fold) compared to the controls. CCPA-induced upregulation of A1AR, î-PKC, iNOS, HSP 72i, and the opening of both mitochondrial and sercolemmal KATP channels may possibly participate in signaling cascade. Our study suggests that A1AR activation up-regulates iNOS, HSP 72i via î-PKC signaling pathway to active both mitochondrial and sarcolemmal KATP channels for cellular protection against SI in the acultured PCSMC.


    797/2523

    Tytuł oryginału: Influence of diethyldithiocarbamate on the activity of ecto-ATPase in lymphocytes of rats: ex vivo studies.
    Autorzy: Purzyc Leszek, Całkosiński Ireneusz, Polak-Jonkisz Dorota
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.455-467, il., tab., bibliogr. 42 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Influence of diethyldithiocarbamate (DTC) on the activity of ecto-ATPase (plasma membrane-bound enzyme participating in a cascade of reactions leading to the formation of adenosine - a modulator of inflammation) was examined on the lymphocytes isolated from the spleen of rats with inflammation. DTC was administered at doses of 4 mg/kg and 290 mg/kg using two modes of administration. It has been observed that: a) an inflammation caused an increase in ecto-ATPase activity in both subpopulations of lymphocytes; in the case of B-lymphocytes, the maximum of activity occurred 48 h and in the cases of T-lymphocytes, 72 h after the injection of carrageenin; b) a single injection of DTC at boht doses, 24 h before or 24 h after carrageenin injection caused a decrease in ecto-ATPase activity in B-lymphocytes and its incresase in T-lymphocytes throughout the whole measurement period, which was not observed when DTG was administered only after provocation of inflammation; c) administration of a high dose of DTC togehter with equimolar doses of disulfiram and CS2 led to a decrease in ecto-ATPase activity and 5'-nucleotidase level in B-lymphocytes, which is bound to the former enzyme; d) in in vitro studies, both populations of lymphocytes isolated from the rats treated with a four-fold dose of DTC showed higher resistance of ecto-ATPase to inhibitors of the enzyme and antagonists of type P2 purinoceptors.


    798/2523

    Tytuł oryginału: Effects of combination of cyclosporine with losartan or enalapril on kidney function in uremic rats.
    Autorzy: Azzadin Arsalan, Małyszko Jolanta, Małyszko Jacek S., Tankiewicz Anna, Myśliwiec Michał, Buczko Włodzimierz
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.469-473, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Long-term treatment with cyclosporine in solid organ transplantation has been shown to be associated with the development of hypertension and nephrotoxicity. Angiotensin-converting enzyme inhibitors have well-known nephroprotective properties and may prevent cyclosporine A (CYA)-induced hypertension. Angiotensin receptor I antagonists have similar properties. The purpose of this study was to investigate if losartan or enalapril could be administered with CYA to reduce its nephrotoxic effect in uremic rats. The studies were performed on the following groups of rats: group I - control; group II - control rats + lossartan; group III - control rats + CYA; group IV - uremic rats; group V - uremic rats + losartan; group VI - uremic rats + CYA; group VII - uremic rats + losartan + CYA, group VIII - control rats + enalapril; group IX - control rats + enalapril + CYA; group X - uremic rats + enalapril; group XI - uremic rats + enalapril + CYA. Pretreatment with CYA, losartan or enalapril in uremic rats resulted in a significant increase in urea and creatinine levels and a decrease in hematocrit. The same effect was observed when uremic rats were given CYA + losartan or CYA + enalapril. Pretreatment with losartan was associated with the increase in the level of CYA much higher than with CYA treatment alone. Similarly, pretreatment with enalapril resulted in a significant increase in CYA concentration in both groups of rats given CYA: uremic and non-uremic. Results of our study show that the treatment with cyclosporine and a combination of losartan or enalapril results in an increase in creatinine...


    799/2523

    Tytuł oryginału: Effect of capsaicin on ion transport in the caecum of rabbits.
    Autorzy: Kosik-Bogacka Danuta, Banach Bolesław, Tyrakowski Tomasz
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.475-482, il., bibliogr. 38 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Effect of capsaicin, a stimulator of C-fibres, on ion transport in the caecum of rabbits was studied using electrophysiological methods, designed to evaluate ionic currents occurring in epithelial tissues. The experiments consisted inmeasuring transepthelial electrical potential difference (dPD) of an isolated fragment of ragbbit's caecum, placed ina Ussing apparatus. The ion transport was modified through incubation in Ringer solution, supplemented with amiloride, bumetanide, and capsaicin. Capsaicin was also administred with persistalting pump. The experiments demonstrated that the inhibition of sodium ions transport caused by incubation with amiloride and incubation with capsaicin slowed down mechanical reaction to electrical potential difference. On the other hand, immediately after the other hand, immediately after the administration, the capsaicin effect on C-fibres modified electrophysiological reaction of the caecum to mechanical stimulation. Physiological and pharmacological experiemnts reveal that a component dependent on activation of C-fobres contributes to the reaction of ion transport activation following mechanical stimulation.


    800/2523

    Tytuł oryginału: Modulation by cationic amphiphilic drugs of serine base-exchange, phospholipase D and intracellular calcium homeostasis in glioma C6 cells.
    Autorzy: Bobeszko Marta, Czajkowski Rafał, Wójcik Magdalena, Sabała Paweł, Lei Lingsheng, Nalepa Irena, Barańska Jolanta
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.483-493, il., bibliogr. 37 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: We aimed to assess the effect of three drugs belonging to amphiphilic cations, imipramine, amitriptyline and propranolol, on lipid synthesis and intracellular calcium homeostasis in glioma C6 cells. Antidepressants, imipramine and amitriptyline, had a stimulatory effect on [14C]serine incorporation into phosphatidylserine. Similar effect was induced by propranolol, antidysrhythmic drug and an antagonist of á-adrenergic receptor, but not by isoproterenol, a selective agonist of this receptor. Stimulation of serine base-exchange activity by amphiphilic cations occured at concentration as low as 5 - 25 ćM that may be reached during clinical treatment. At much higher concentration (250 ćM), those drugs also stimulated phospholipase D-mediated synthesis of [14C]phosphatidylethanol and blocked phorbol ester-induced, protein kinase C-dependent phospholipase D activity. The latter effect already occurred at low (25 ćM) concentration of drugs. We have also shown that treatment of the cells with amphiphilic cations (1 mM) produced only a weak incrase in the intracellular Ca2+ concentration and did not affect Ca2+ release from the intracellular stores evoked by nucleotide receptor agonists, ATP and ADP. In contrast, this treatment strongly diminished an unspecific leak of Ca2+ from the endoplasmic reticulum caused by thapsigarin and ionomycin. Mianserin, which is not cationic amphiphilic drug, did not affect phosphatidylserine synthesis and phospholipase D activity and produced heterogenous and chaotic Ca2+ responses. Our results suggest that imipramine, amitriptyline and propranolol may modulate lipid synthesis and intracellular calcium signaling independently of theis action on membrane receptors, most probably by modification of the physicochemical properties of cell membranes.


    801/2523

    Tytuł oryginału: Distribution of allelic variants of functional C3435T polymorphism of drug transporter MDR1 gene in a sample of Polish population.
    Autorzy: Jamroziak Krzysztof, Balcerczak Ewa, Młynarski Wojciech, Mirowski Marek, Robak Tadeusz
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.495-500, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: P-glycoprotein (P-gp), the protein product of MDR1 gene, is an important factor regulating the bioavailability of many therapeutics. Recently, the C3435T polymorphism of MDR1 was correlated to altered expression and function of P-gp in normal tissues. In this study, polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess C3435T MDR1 polymorphism in 122 healthy individuals of Slavic origin from the population of central Poland (Łódź and surrounding areas). The detected genotype variant frequencies were as follows: CC in 42 p.c., CT in 41 p.c., and TT in 17 p.c. of the tested subjects (C-allele frequency was 0.62). The frequency of the C-allele is similar to Japanese population and significantly higher than in Caucasians from Western Europe. The results of this study give basis for large-scale C3435T MDR1 genotype-phenotype correlation investigations in Polish population that may be useful to individualize therapy of cancer, HIV-1 infection and some other diseases.


    802/2523

    Tytuł oryginału: Influence of midazolam on pharmacokinetics of verapamil in rabbits.
    Autorzy: Orszulak-Michalak Daria, Owczarek Jacek, Wiktorowska-Owczarek Anna K.
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.501-506, tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Calcium channel blockers can get involved in pharmacological interactions when used concomitantly with other drugs. Previous reports indicate a differential influence of various general anesthetics on verapamil pharmacokinetics. A tendency of a faster transfer of verapamil from the central compartment to the tissue compartment was found to be associated with a slower drug return from the tissue at the given verapamil doses during thiopental or propofol anesthesia. Thus, an increased storage of verapamil in tissue compartment and prolongation of the drug action may occur due to those interactions. The aim of the study was to investigate the influence of midazolam on the plasma concentrations and pharmacokinetic parameters of verapamil after intravenous bolus administration in rabbits during 2 h of observation. Verapamil and midazolam were administered intrtavenously at a dose of 0.2 mg/kg. Verapamil levels in plasma were determined by radioanalysis using [3H]verapamil. Levels of verapamil were determined in plasma at 5, 10, 15, 30, 45, 90 and 120 min after the administration, and plasma disappearance was analyzed according to the non-compartmental and 2-compartmental model. After administration of midzaolam together with verapamil, a decrease in verapamil concentration in plasma was seen, with an increased verapamil transfer to the tissue compartment, increased steady state distribution volume and shortened residency time of the drug in the plasma.


    803/2523

    Tytuł oryginału: Indoor air studies of fungi contamination of social welfare homes in Białystok and the surrounding area during summer and autumn.
    Tytuł polski: Badania powietrza domów pomocy społecznej w Białymstoku i okolicy pod względem występowania grzybów w okresie lata i jesieni.
    Autorzy: Krajewsak-Kułak Elżbieta, Łukaszuk Cecylia, Oksiejczuk Elżbieta, Gniadek Agnieszka, Macura Anna B., Lewko Jolanta, Niczyporuk Wiaczesław, Cieślak Wojciech, Wojewodko Agata
    Źródło: Mikol. Lek. 2002: 9 (2) s.59-66, il., tab., bibliogr. 21 poz., sum.
    Sygnatura GBL: 313,181

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: Wstęp: W okresie ostatnich lat liczba zakażeń grzybiczych u pacjentów hospitalizowanych ulegla podwojeniu. Cel badania: Ocena występowania grzybów drożdzopodobnych i pleśni w powietrzu w domu pomocy społecznej w Białymstoku i okolicy. Materiał i metody: Zanieczyszczenie powietrza (przed budynkiem, w korytarzach, salach chorych, pokojach socjalnych, kuchniach, łazienkach, toaletach) oceniano przy użyciu urządzenia SAS SUPER 100 (Pbi International). SAS stosowany był przez NASA oraz na pokładzie amerykańsko-rosyjskiej stacji orbitalnej MIR. Posiada on międzynarodowy, ustalony standard pobierania próbek powietrza. Florę grzybiczą ze ścian, podłóg, łóżek, rąk personelu i ubrań uzyskiwano przy użyciu aplikatora Count-Tact applicator i płytki Count-Tact (BioM‚rieux). Wymazy pobierano ze skóry i przestrzeni międzypalcowych rąk i stóp, paznokci i jamy ustnej. Grzyby hodowano na podłożu Sabourada, a ich identyfikację przeprowadzano przy użyciu standardowych procedur. Wyniki: Badania mikrobiologiczne powietrza oraz ścian wykazały istotne różnice w występowaniu flory grzybiczej w zależności od miejsca izolacji (korytarze, sale chorych, pokoje socjalne, kuchnie, łazienki, toalety itd.) i pory roku (lato, jesień). Znamienny wzrost izolacji grzybów z powietrza i ścian w domach pomocy społecznej stwierdzono jesienią. Podobny wzrost izolacji grzybów wykazano u mieszkanców jesienią. Grzyby drożdżopodobne izolowane od mieszkańców domów pomocy społecznej były wrażliwe na leki ...

    Streszczenie angielskie: Introduktion: Durng the recent years the number of fungal infections in hospital patients has doubled. Aim of study: The contamination of the indoor environment with yeast-like fungi and moduls in social welfare homes in Białystok and the surrounding area was evaluated. Material and methods: The air pollution (in front of the building and in the corridors, patient rooms, study rooms, reaction rooms, kitchens, bathrooms, toilets, ventilation systems) was determined using SAS SUPER 100 (Pbi International). The SAS (surface Air System) was used by NASA and in the joint American-Russian space program on board the MIR orbiting station for portable air sampling. The microbial flora from walls, floors, beds, hands of medical stuft and equipment was assessed using the Count-Tact applicator and the plate Count-Tact (BioM‚rieux). Swabs were taken from the skin of the interdigital spaces of feet and hands, nails and the oral cavity. The fungi from the swabs were cultured on Sabouraud medium. Fungi were identified using standard microbial procedures. Results: Microbiological tests of air and walls revealed significant differences in mycological flora depending on the place of isolation (corridor, rooms, reading room, nurse, room, itchen, dining room, bathroom ect.) and season (summer, autumn). A significant increase in the fungi isolated from the air and walls in the social welfare homes was found, during autumn. An increase in the fungi isolated from residents was found in ...


    804/2523

    Tytuł oryginału: Enzymatic biotypes of the yeast-like fungi strains and their susceptibilities to antimycotics isolated from ontocenosis of the urogenital system.
    Tytuł polski: Biotypy enzymatyczne a lekowrażliwość szczepów grzybów drożdżopodobnych izolowanych z ontocenozy narządów moczowo-płciowych.
    Autorzy: Krajewska-Kułak Elżbieta, Łukaszuk Cecylia, Niczyporuk Wiaczesław, Trybuła Jadwiga, Szczurzewski Maciej
    Źródło: Mikol. Lek. 2002: 9 (2) s.67-74, il., tab., bibliogr. 21 poz., sum.
    Sygnatura GBL: 313,181

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • urologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Cel: Określenie biotypów enzymatycznych szczepów Candida albicans wyhodowanych z ontocenozy narządów moczowo-płciowych oraz wykazanie ewentualnej zależności pomiedzy biotypem a lekowrażliwością. Materiał i metody: Badaniem objęto szczepy Candida albicans izolowane z materiału pobranego od pacjentów z kandydoz - 132 szczepów wyhodowanych z ontocenozy cewki moczowej oraz 160 szczepów z ontocenozy pochwy. Aktywnlość enzymatyczną oceniano przy użyciu testu API ZYM firmy bioM‚rieux. Lekowrażliwość oznaczano za pomocą testu FUNGITEST (Bio-Rad). Biotypowanie szczepów przeprowadzono według klasyfikacji Williamsona oraz Kurnatowskiej i Kurnatowskiego. Wyniki: Szczepy izolowane z ontocenozy cewki moczowej cechowała najwyższa aktywność arylamidazy leucynowej, arylamidazy, N-acetylo-á-glukozy-loamidazy, zaś izolowane z pochwy - arylamidazy leucynowej. esterazy oraz lipazy esterazowej. Szczepy Candida albicans hodowane z cewki w największym odsetku wykazywały cechu biotypu A (59,1 proc.), z pochwy - biotypu F (35 proc.). Izolaty z cewki moczowej były najbardziej wrażliwe na 5-fluorocytozynę, a oporne głównie na itrakonazol. Największą oporność na badane leki przeciwgrzybicze wykazywały szczepy o cechach biotypów I i G. Szczepy z pochwy cechowała największa wrażliwość na amfoterycynę B, a oporność głównie na ketokanazol i mikonazol. Największą oporność na badane leki przeciwgrzybicze miały szczepy o cechach biotypów E i F. Wnioski: Najwięcej izolatów Candida albicans wyhodowanych ...

    Streszczenie angielskie: Aim: Determination of the enzymatic biotypes of Candida albicans isolated from ontocenosis of the urogenital system and assessment of possible correlations between biotypes and their susceptibilities. Material and methods: 132 Candida albicans strains isolated from patients with candidiasis of the urethra and 160 from the vagina were evaluated. The enzymatic activity of the Candida albicans strains was determined by using the API-ZYM test M‚rieux and their susceptibility using the FUNGI-TEST Bio-Rad. Biotyping of all strains was done according to Williamson's, and Kurnatowska and Kurnatowski's classification. Results: The isolates from the urethra had the highest enzymatic activity of leucine and N-acetyl-á-glucosaminidase from the vagina - leucine arylamidase, esterase and esterase lipase. The enzymatic biotypes of Candida albicans from the urethra had the highest pecentage of biotype A 59.1 p.c. and from vagina biotype F - 35 p.c. The isolates from the urethra had the highest susceptibility to 5-fluorocytosine, the lowest to itraconazole. Strains of biotype I and G had the highest resistance to the antimyocotocs tested. The isolates from the vagina were sensitive to amphotericin B but less sensitive to ketoconazole and miconazole. Biotype E and F had the highest resistance to the drugs tested. In conclusions: Most of the isolayes of candida albicans from the urethra and vagina bekonged to biotypes of Williamson's classification. The isolates from the urethra ...


    805/2523

    Tytuł oryginału: Clinical characteristics of hereditary ovarian cancer (HOC) in Poland.
    Autorzy: Menkiszak Janusz, Górski Bohdan, Jakubowska Anna, Gronwald Jacek, Huzarski Tomasz, Byrski Tomasz, Foszczyńska-Kłoda Małgorzata, Fliciński Jacek, Brzosko Marek, Rzepka-Górska Izabella, Lubiński Jan
    Źródło: Ginekol. Pol. 2002: 73 (9) s.733-739, tab., bibliogr. 24 poz., streszcz.
    Sygnatura GBL: 301,184

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: W pracy przedstawiono charakterystykę kliniczna dziedzicznego raka jajnika (DRJ) w populacji polskiej. Oceniano wiek zachorowania, stopnie zaawansowania klinicznego (FIGO), stopnie morfologicznej złośliwości (G) oraz częstość występowania raka typu surowiczego. Analizie poddano 142 DRJ z 82 rodzin, które następnie sklasyfikowano na badane grupy i podgrupy na podstawie danych rodowodowo-klinicznych i wyników badan molekularno-genetycznych na obecność mutacji konstytucyjnych genu BRCA1. Zebrane dane poddano analizie statystycznej. Stwierdzono, że cechy kliniczne DRJ w Polsce oraz innych krajach są podobne, a poszerzenie kryteriów rodowodowo-klinicznych o testy DNA umożliwia wykrywanie podgrup DRJ o odmiennych cechach klinicznych.

    Streszczenie angielskie: Background: Hereditary ovarian cancer (HOC), as any genetic disease, may display clinical characteristics that depends on population. Aim of the study: The aim of the study was to described clinical characteristics of HOC in Polish population basing on analysis of the following features: age at onset, clinical staging, morphological grading and prevalence of serous adenocarcinoma. Material and method: The cases were selected basing on analysis of pedigree/clinical features and molecular studies of founder mutations of BRCA1 gene in Poland. results: The patients; age at diagnosis was ca 49-52 and was similar in all groups. The exception was the subgroup without mutations in group II (breast and ovarian cancers found in families) with mean age at diagnosis ca 46 years (n = 9). In patients with HOC without mutation of BRCA1 gene, lower FIGO stage and lower morphological grade were detected more frequently. The majority of HOC showed histopathological pattern of serous adenocarcinoma. Conclusions: 1. Clinnical features of HOC in Poland and in other countries are similar. 2. Introduction of DNA test to the clinical and pedigree diagnostic criteria allows detection of subgroups of HOC with different clinical features.


    806/2523

    Tytuł oryginału: Central nervous system activity of new pyrimidine-8-on[2,1-f]theophylline-9-alkylcarboxylic acids derivatives.
    Autorzy: Fhid Omeran, Pawłowski Maciej, Filipek Barbara, Horodyńska Renata, Maciąg Dorota
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.245-254, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The appropriate esters 1-3 were synthesized by the alkylation of unsubstituted pyrimidin-8-on[2,1-f]theophylline I with ethyl-chloroacetate, ethyl-acrylate and ethyl-4-bromobutyrate. The acids 4-6 were obtained by hydrolysis of the esters 1-3, and transformed into Na salts 4a-6a. Amidation of the ester 1 with 25 p.c. ammonia and hydroxylamine led to amide 7 and N-hydroxyamide 8. The bromination of 1 gave 7-bromo intermediate 9 transformed to the 7-amino derivatives via nucleophilic substitution with phenylpiperazine for compound 10 and morpholine for compound 11. In the reaction of 9, 10 and 11 with sodium alcoholate, the corresponding Na salts 12a-14a were obtained. The pharmacological properties of the compounds were tested in CNS activity screening. It was found that all the investigated compounds produced significant sedative effects in behavioral tests except weak activity of pyrimido[2,1-f]theophyline-9-sodium acetate 4a. The potent activity of pyrimido[2,1-f]theophylline-9-sodium butyrate 6a, pyrimido-[2,1-f]theophylline-9-acetamide-7, 7-N-phenylpiperazine-pyrimid[2,1-f]theophylline-9-sodium acetate 13a, and 7-N-morpholine-pyrimido[2,1-f]theophylline-9-sodium acetate 14a was observed. They inhibited spontaneous locomotor activity, potentiated sedation and prolonged duration of sleeping time after thiopental sodium administration. All compounds had no effects in the test of analgesia and they showed weak anti-convulsant properties. The results ofthis investigation may hypnotic, sedative and/or tranquillizing properties of the tested compounds.


    807/2523

    Tytuł oryginału: Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue.
    Autorzy: Sleyman Halis, Altinkaynak Konca, G”cer Fatma, Maras Ahmed, Akcay Fatih, Onuk M. Derya, Gepdiremen Akcahan
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.255-259, tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro
  • płeć męska

    Streszczenie angielskie: In this study, we examined the effect of nimesulide and ranitidine on the indomethacin- and ibuprofen-induced ulcer. In addition, we investigated whether there was a direct chemical interaction of nimesulide and ranitidine with indomethacin, and also whether nimesulide and rantidine neutralized the gastric acid in vitro. Our studies showed that nimesulide (100, 300, 500 ng/kg) prevented the indomethacin-induced gastric ulcers completely. Ranitidine at a dose of 150 mg/kg reduced the mean ulcer area to 2.5 ń 0.76 mmý in the indomethacin-treated and to 2.0 ń 0.81 mmýin ibuprofen-treated rats. The mean ulcer areas in rats given only indomethacin and only ibuprofen were 20.3 ń 1.58 mmý and 9.5 ń 1.43 mmý, respectively. There were no chemical reactions between nimesulide and indomethacin or ranitidine and indomethacin in vitro. Nimesulide and ranitidine did not neutralize the gastric acid in vitro.


    808/2523

    Tytuł oryginału: Comparison of motor reactivity of the colonic muscularis mucosae isolated from human, guinea pig and rat in vitro.
    Autorzy: Kamikawa Yuichiro, Shibukawa Asako, Uchida Kohsuke, Sakuma Atsushi, Kubota Kei-ichi, Ohno Yasuo
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.261-266, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • Świnki morskie
  • in vitro

    Streszczenie angielskie: We have compared the reactivity to spasmogens of longitudinal muscularis mucoase isolated from the human, guinea pig and rat colon in vitro. The muscularis mucosae isolated from the human distal colon responded with a sustained contractions to carbachol (10 nM - 30 ćM), in a concentration-dependent manner, and the maximum contraction was comparable to that with potassium concentration (100 mM). Among several spasmogens, neurokinin A was the most potent with the following order of potency: carbachol, prostaglandin F2ŕ an dacetylcholine. Histamine, 5-hydroxytryptamine and bradykinin did not produce a recognizable contraction of this tissue. The muscularis mucosae isolated from the guinea pig distal colon demonstrated a concentration-dependent contraction in response to neurokinin A, carbachol, histamine and acetylcholine, but not to prostaglandin F2ŕ or 5-hydroxytryptamine, and the maximum contraction was obtained with histamine. The muscularis mucoase from the rat distal colon was very sensitive to neurokinin A and bradykinin, less to carbachol and acetylcholine, and not at all sensitive to histamine, 5-hydroxytryptamine and prostaglandin F2ŕ. It is concluded that the colonic muscularis mucoase respond to pharmacological agents in a species-different manner.


    809/2523

    Tytuł oryginału: Effect of capsaicin and dimethyl sulfoxide on ion transport in the selected experimental models.
    Autorzy: Kosik-Bogacka Danuta I., Banach Bolesław, Tyrakowski Tomasz, Wojciechowska Iwona
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.267-274, il., tab., bibliogr. 46 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • Żaby
  • in vitro

    Streszczenie angielskie: The aim of the present work was to determine the changes in ion transport in the selected epithelium-lined organs under influence of mechanical stimuli, and also to assess similarities and differences in reactions to capsaicin and dimethyl sulfoxide (DMSO) between trachea and caecum of rabbit and the skin of frog in this experimental setup. The experiments were conducted on rabbit trachea and caecum, and the skin of frog, Rana esculenta L. The experiments consisted in measuring transepithelial electrical potential (PD in mV) with Ussing apparatus, modified to enable testing of the effects of mechanical stimulation of organs and defined pharmacological treatments. It was demonstrated that the addition of DMSO to the stimulating fluid decreased reversible hyperpolarization (dPD) after mechanical stimulation by at least 50 p.c. in all studied groups. On the other hand, action of capsaicin was dependent on the organ studied as well as on experimental conditions (e.g. type of incubation). Capsaicin decreased PD and reaction to mechanical stimulation in trachea incubated in Ringer solution supplemented with amiloride. On the other hand, it did not influence electrophysiological parameters of the trachea following its incubation with bumetanide. Capsaicin did not change electrical potential or reactivity of rabbit caecum incubated with both amiloride and bumetanide. The administration of capsaicin on frog skin incubated with bumetanide casued inhibition of the reaction to mechanical stimulation, whereas during incubation with amiloride no changes were recorded in PD and dPD of the skin. The present study demonstrated that capsaicin and DMSO could modify processes of ion transport dependent on mechanical stimulation.


    810/2523

    Tytuł oryginału: Effects of some drugs on rat erythrocyte 6-phosphogluconate dehydrogenase: an in vitro and in vivo study.
    Autorzy: Ciftci Mehmet, Beydemir Skr, Yilmaz Hayrullah, Bakan Ebubekir
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.275-280, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: The in vitro and in vivo effects of some drugs on rat erythrocytes 6-phosphogluconate dehydrogenase were investigated in this study. Rat erythrocyte 6-phosphogluconate dehydrogenase was partially purified with ammonium sulfate precipitation. The enzyme activity was determined by Beutler's method. Some drugs such as ampicilin, amikacin sulfate, and netilmicin sulfate inhibited the enzyme activity in in vitro conditions, while metamizole activated it. The I50 values of the inhibiting drugs were 66.2, 5.836, and 0.963 mM, respectively. For the drugs having low I50 values (drug concentrations which produce 50 p.c. inhibition) (amikacin sulfate and netilmicin sulfate), in vivo studies were performed in rats (Sprague-Dawley). Amikacin sulfate at 64 mg/kg inhibited the enzyme activity significantly (p 0.05) 2 h after dosing. Netilmicin sulfate at 6.4 mg/kg also inhibited the enzyme significantly (p 0.05) 4 h after dosing. Amikacin sulfate and netilmicin sulfate inhibited rat erythrocyte 6-phospogluconate dehydrogenase both in vivo and in vitro. The enzyme was inhibited in vitro by ampicillin and activated in vitro by metamizole.


    811/2523

    Tytuł oryginału: Homocysteine-induced augumentation of spontaneous contraction of isolated guinea pig myometrium.
    Autorzy: Ayar Ahmet, Tug Niyazi, Celik Husnu, Ozcan Mete, Ozcelik Oguz
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.281-284, il., bibliogr. 18 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie
  • płeć żeńska
  • ciąża
  • in vitro

    Streszczenie angielskie: Recent studies have suggested association between the elevated homocysteine levels and pregnancy complications. The aim of this study was to investigate the effects of homocysteine on spontaneious contractions of myometrium isolated from pregnant guinea pig. Full-thickness myometrial strips were obtained from late-pregnant guinea pigs following decapitation, and suspended in an organ bath which was filled with physiological saline solution (pH 7.4), maintained at 37řC and continuosly bubbled with 95 p.c. O2 and 5 p.c. CO2. After the observation of spontaneous contarctions under one gram of resting tension, homocysteine (0.2, 0.5 and 1 mM) was added to the organ bath and effects off this agent on frequency and amplitude of contractions were evaluated in 20 min periods. One-way analysis of variance was used for statistical analysis of the data. Homocysteine caused increase in both frequency and amplitude of spontaneous contractions in a dose-dependent manner. The results from this in vitro study indicate that cardiovasular risk factor homocysteine has contracting pharmcological effects on guinea pig myometrium.


    812/2523

    Tytuł oryginału: Prescribing pattern of anti-seizure medications (ASMs): an evaluation of extent of xanthine co-medication.
    Autorzy: Manjula Devi, David Joy, Kulkarni Chanda
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.285-291, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • pulmonologia
  • neurologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This study was conducted to evaluate the prescribing pattern of anti-seizure medications (ASMs) at a tertiary care hospital. The extent and pattern of concurrently used medications for co-exiting illnesses was also studied. Attention was focussed in particular on co-existence of bronchial asthma with epilepsy and co-medication of ASMs with xanthines. The study was carried out at the Central Pharmaacy and at the Medical Records Department. Data analysis at the central pharmacy showed 3.98 p.c. prescriptions for ASMs, with maximum number for males. More drugs were prescribed during the second decade of life and there were 2.17 drugs per prescription. The data for pattern and extent of use of ASMs along with polutherapy and concurrently used medications revealed the highest number of prescriptions for phenytoin, maximum number with single ASM, and phenytoin with phenobarbitone as most frequently prescribed combination. Co-administartion of ASMs with respiratory medications was found in 2.47 p.c., with 38.8 p.c. prescriptions having xanthines prescribed in them. Xanthines, the well known CNS stimulants, a property attributed to their adenosine receptor antagonistic activity, are considered potential seizurogenic agents. The results of the present preliminary survey show an indirect evidence for co-existence of epilepsy with asthma along with the extent of co-medication of ASMs with xanthines. Results indicate the need for further studies to evaluate the consequences of co-medication of ASMs with xanthines.


    813/2523

    Tytuł oryginału: Analytical studies on two amino acid derivatives of anticonvulsant activity.
    Autorzy: Pirianowicz-Chaber Elżbieta, Paruszewski Ryszard
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.239-241, il., tab., bibliogr. 5 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Qualitative and quantitative methods of analysis of two new amino acid derivatives, potential anticolvulsants of low neurotoxicity: N-acetyl-ç-aminobutyric acid benzylamide (1) and N-methyl-ç-aminobutyric acid benzylamide (2) were developed. Qualitative analysis includes characteristic colour reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation and quantitative analysis involves spectrophotometric, chromatographic (HPLC), acidimetric and argentometric methods.


    814/2523

    Tytuł oryginału: Stability of cefepime dihydrochloride monohydrate in solid state.
    Autorzy: Musiał Wojciech, Zając Marianna
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.243-246, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The pseudo first-order rate constants and thermodynamic parameters for the decomposition of cefepime in solid state in absence of hymidity and at a relative humidity of 76.4 p.c. were calculated. The effect of humidity on the stability of cefepime dihydrochloride monohydrate in the humidity range 25.0 p.c. - 76.4 p.c at 358 K is described by the equation ln ki + (0.031 ń 0.0043) ú RH p.c. - 10.08 ń 0.22.


    815/2523

    Tytuł oryginału: Studies on the influence of auxiliary substances on the physico-chemical characteristics of ophthalmic drugs. P. 1: Studies on the influence of auxiliary substances on the critical micellar concentration of surfactants solutions in eye drops containing sulphacetamidum natricum.
    Autorzy: Pluta Janusz, Meler Jan
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.247-252, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Interactions between Tweens, surfactants used in eye drops and the remaining compounds of the preparations were investigated. The interactions were assessed by means of the surface tension measurement method. Obtained results demonstrate that the substances used in the facture of the preparation affect the critical miclear concentrations of Tweens. Only hydroxyethylcellulose was found to exert a stabilizing effect on the critical micellar concentration of these substances. The amount of used surfactant should be taken into consideration in the manufacture of eye preparations.


    816/2523

    Tytuł oryginału: Effect of various vehicles on diclofenac sodium and indomethacin pharmaceutical availability.
    Autorzy: Stożkowska Wiesława
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.253-260, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of the study was to determine the pharmaceutical availability of various ointment systems containing antirheumatic substances and to estabilish an optimal system for cutaneous application. Topical application permits elimination or at least reduction of side effects connected with oral administration. Three systems were evaluated: emulsion W/O (ointment), emulsion O/W (cream) and gel, all of them containing diclofenac sodium or indomethacin. The investigated systems are characterized by proper rheological parameters and long physiochemical stability. Studies on diclofenac and indomethacin pharmaceutical availability show a good release of the substances from cream and hydrogel bases, but a very poor release from the ointment base.


    817/2523

    Tytuł oryginału: Investigations of the thymomimetic activity of a selected phytopharmaceutical preparation - reumaherb tablets by flow cytometry.
    Autorzy: Prosińska Joanna, Sawicka Teresa, Drozd Janina
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.265-273, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 301,378

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The aim of the present study was to investigate the influence of Reumaherb tablets, a plant preparation, on th ematuration of mice thymocytes in the presence of glycocorticosteroid by the method of cytotoxicity test performed in vitro in two versions differing in methodology. The cell source for incubation was thymus of female Balb/c mice, four weeks old. Reumaherb tablets were added to the culture of thymocytes diluted by a factor of 10-400. The searched thymomimetic activity of the investigated Reumaherb preparation was found in both versions of the test, this being demonstrated by a 17 p.c. increase in the number of surviving cells in the presence of glycocorticosteroid added to the culture. This effect strongly depends on the applied doses. By a microscopic evaluation of the results a maximum stimulation was found at a 200-fold dilution of the examined preparation, while in the cytometric analysis a similar maximum effect was observed at a 20-fold dilution.


    818/2523

    Tytuł oryginału: Flavonoids from some species of genus Scopolia Jacq.
    Autorzy: Nowak Sławomira, Wolbiś Maria
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.275-280, tab., bibliogr. 23 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Kaempferol 3-O-(2-glucosyl)-galactoside-7-O-glucoside was isolated from the leaves of Scopolia carniolica Jacq. and S. sinensis Hemsl. From the latter taxon as well as kaempferol 3-O-galactoside and 3-O-(2-glucosyl)-galactoside, kaempferol and quercetin 3-O-robinobiosides and quercetin 3-O-sophoroside have been obtained. Moreover, from the leaves of S.lurida Dun. kaempferol and quercetin 3-O-glucosides and 3-O-rutinosides were isolated. The structures of compounds have been determined by means of chemical and spectral methods (UV, LSI MS, 1H and 13C NMR, 1H - 1H COSY NMR).


    819/2523

    Tytuł oryginału: Synthesis and some pharmacological properties of 3-(4-phenyl-5-oxo-1,2,4-triazolin-1-ylmethyl)-1,2,4-triazolin-5-thione derivatives.
    Autorzy: Dobosz Maria, Struga Marta, Chodkowska Anna, Jagiełło-Wójtowicz Ewa, Stępniak Krystyna, Kozioł Anna E.
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.281-290, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: In the reaction of (4-phenyl- or 3,4-diphenyl-5-oxo-1,2,4-triazolin-1-ylmethyl)-carbohydrazide (IIa, IIb) with isothiocyanates the thiosemicarbazide derivatives [IIIa, b - IXa, b] were obtained. Cyclization of those compounds in the presence of 2 p.c. or 10 p.c. NaOH led to formation of derivatives with the 1,2,4-triazolin-5-thione system [Xa, b - XVIa, b]. Molecular structure proposed for this group of compounds was confirmed by X-ray structure analysis of Xa and XIVa. Compounds Xa, XIIa and XIVa were investigated pharmacologically for their central properties in mice. It was shown that only compound XIIa produces antinociceptive effects in mice.


    820/2523

    Tytuł oryginału: Synthesis, structural characterization and antimicrobial studies of hydrazone derivatives of 3-hydroxyimino-5-methyl-2-hexanone.
    Autorzy: Donde Kamini J., Patil Vishwanath R., Utekar Shilpa S., Malve Sheela P.
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.291-293, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The derivatives of 3-hydroxyimino-5-methyl-2-hexanone oxime have been obtained in good yield by its reactions either with hydrazine hydrate or phenyl hydrazine, respectively. IR and 1H NMR spectral data of these compounds have been discussed. All the newly synthesised compounds have been tested for their biological activity against S. auerus, S. typhi, C. albicans, A. niger, S. cerevisiae and M. tuberculosis H37RV.


    821/2523

    Tytuł oryginału: Quantitative structure-activity relationships study of a series of imidazole derivatives as potential new antifungal drugs.
    Autorzy: Wiktorowicz Włodzimierz, Markuszewski Michał, Krysiński Jerzy, Kaliszan Roman
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.295-306, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The Quantitative Structure-Activity Relationships (QSAR) has been developed to relate antifungal activity against Candida albicans and Rhodotorula glutinis of new imidazole derivatives with their physico-chemical and structural properties. For 265 midazole derivatives the most significant statistically equations has been obtained with correlation coefficients R = 0.800 and R = 0.820 in case of activity against C.a. and Rh.g., respectively. The overall antifungal activity has been described by means of size and bulkiness releated parameters as well as polar and lipophilic interactions. The significance of lipophilicity in terms of n-octanol/water partition coefficient, ClogP, on antifungal potency against both fungi has been investigated. QSAR equations for different classes of antifungal activity have been obtained. With a very high probability level (92 p.c. and 96 p.c.) the weak or wery weak antifungal potency aganst C.a. can be determined and thus the number of required experiments can be reduced.


    822/2523

    Tytuł oryginału: Effect of chronic hyperglycemia and vanadate treatment on erythrocyte Na/K-ATpase and Mg-ATpase in streptozotocin diabetic rats.
    Autorzy: Totan Alexandra Ripszky, Greabu Maria
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.307-311, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: We have studied Na/K-ATPase and Mg-ATPase activities in red blood cells of diabetic rats treated in vivo with sodium vanadate. To our knowledge the effect of in vivo vanadate treatment on these two enzymes has not been studied. Red blood cell Na/K-ATPase plays a central role in the regulation of intra- and extracellular cation homeostasis. Alteration of this transport enzymes is thought to be linked to several complications of diabetes mellitus: hypertension, nephropathy, peripherical neuropathy and microangiopathy. An Mg2+ - dependent ATPase activity located in the erythrocyte membrane appears to be responsible for controlling the smoothing of echinocytic erythrocytes to discocytes and stomatocytes. Our results show that in alloxan diabetes activities of both ATPases are reduced (especially the activity of Na/K-ATPase). Vanadate treatment of normal animals reduced the activities of both enzymes: with 33.08 p.c. for Na/K-ATPase and 22.76 p.c. for Mg-ATPase. Vanadate treatment of diabetic animals did not affect significantly the inhibition process for Na/K-ATPase. For Mg-ATPase we have obtained a significant cumulative inhibition. These results stand out the different functions and physiologic control mechanism of these two ionic pump in red blood cells.


    823/2523

    Tytuł oryginału: Synthesis of a new antischistosomally active and toxicologically tolerant C-12 monothione surrogate of the universal antihelmintic praziquantel.
    Autorzy: Abo-Ghalia M. H., Soliman A. M.
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.313-320, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: A new C-12 monothione mimic (III) of the universal antihelmintic Praziquantel (I) namely, 2-cyclohexylthiocarbonyl(1,2,3,6,7,11b)-hexahydro-4 -pyrazino[2-1a] isoquinoline-4-one was chemically synthesized and structurally elucidated (Elemental analysis, EI-Mass, 13C-NMR and IR spectroscopy). Antischistosomal potency in the order of ~76 p.c. comparable to that for our newly reported C-12 and C-4 dithion mimic II (~70 p.c.) and Praziquantel. Praziquantel (100 p.c., mice infected with S. mansoni cercariae), was realized. Toxicological evaluation (mice liver and kidney functions) and biochemical parameters (cholesterol, triglycerides, albumin, total serum proteins and amino acid profile of liver protein homogenate) were also assayed. Comparable to the parent drug, general insignificant toxicological differences could be attributed for III. Interestingly, III exhibited intermediate biological figures between I and II. An order of II III I with respect to the antischistosomal potency and II III I, for the other tested biochemical parameters was observed. A consideration of obtained results could indicate that, structurally, an intact glycine amide segment of the pyrazine moiety, as it is the case in both I and III, and not in II (glycine thioamide) seemed now more crucial for exhibiting an optimum antihelmintic potency as well as a more tolerant toxicity characteristics. Additionally, the obtained comparable amino acid profile of mice liver protein homogenate after the treatment by III, could suggest ...


    824/2523

    Tytuł oryginału: Lidocaine elimination in patients with liver cirrhosis.
    Autorzy: Wójcicki Jerzy, Kozłowski Kosma, Droździk Marek, Wójcicki Maciej
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.321-324, tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: The aim of the study wa to evaluate lidocaine elimination in patients with liver cirrhosis. The study was carried out in 30 cirrhotic patients classified according to the Child-Pugh's score to subgroups A (n=11), B (n=12) and C (n=7), and 14 helalthy volunteers. Lidocaine was administered intravenously, at a dose of 1 mg/kg, and blood samples for lidocaine and monoethylglycinexylidide (MEGX) assays were collected for up to 6 h. Decreased elimination half-live for lidocaine as well as reduced formation rate of MEGX was found in cirrhotic patients. Lidocaine metabolising capacity of the liver was irrespective of etiology of cirrhosis. It was also found that evaluation of elimination half-life of lidocaine is more closely related to the Child-Pugh's staging of liver dysfunction than 15-minute MEGX concentration.


    825/2523

    Tytuł oryginału: Quantitative determination of coumarins, flavonoids and chlorogenic acid in the leaves and underground parts of some species of genus Scopolia Jacq.
    Autorzy: Nowak Sławomira, Dzido Tadeusz H., Soczewiński Edward, Wolbiś Maria
    Źródło: Acta Pol. Pharm. 2002: 59 (4) s.259-263, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 301,378

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The quantitative determination of coumarins, flavonoids and chlorogenic acid in the leaves and underground parts of Scopolia carniolica Jacq., S. lurida Dun. and S. sinensis Hemsl. using the RP-HLP method has been described.


    826/2523

    Tytuł oryginału: Pharmacological correction of endothelial dysfunction : The 10th Symposium of Jagiellonian Medical Research Centre : final programme
    Opracowanie edytorskie: Gryglewski Ryszard (przedm.).
    Jagiellonian Medical Research Centre in Cracow
    Źródło: - Kraków, JMRC 2002, 92 s. : il., 21 cm. - 10 Sympozjum pt. Farmakologiczny wpływ na dysfunkcje śródbłonka Kraków 02-04.06. 2002
    Sygnatura GBL: 735,463

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    827/2523

    Tytuł oryginału: Molecular epidemiology in preventive medicine : achievements and new challenges : book of abstracts
    Jagiellonian University Collegium Medicum, Department Epidemiology and Preventive Medicine in Krakow
    Źródło: - Kraków, UJ CM 2002, 182, [1] s. : il., tab., 24 cm. - Konferencja pt. Epidemiologia molekularna w medycynie zapobiegawczej - osiągnięcia i nowe cele Kraków 20-22.06. 2002
    Sygnatura GBL: 735,469

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • streszczenie
  • tytuł obcojęzyczny


    828/2523

    Tytuł oryginału: Acute renal failure in patients with rhabdomyolysis.
    Autorzy: Sułowicz Władysław, Walatek Bogusław, Sydor Antoni, Ochmański Władysław, Miłkowski Andrzej, Szymczakiewicz-Multanowska Agnieszka, Szumilak Dorota, Kraśniak Andrzej, Łonak Hanna, Wójcikiewcz Tadeusz
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR24-CR27, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Rhabdomyolysis is a relatively rare, not alwayd diagnosed causes of acute renal failue (ARF). This fact motivated us to present the results of ARF treatment in the course of this polyetiological clinical syndrome. Material/Methods: The analysis was performed on 84 patients (6 F, 78 M) ranging in age from 18 to 82 years (mean 46.5), in whom rhabdomyolysis was diagnosed based on clinical manifestation and laboratory test results (CPK, GTP, GOT, LDH). Results: The most frequent cause of rhabdomyolysis was alcoholic intoxication (41 patients), often accompanied by hypothermia (15 patients) or trauma (30 patients) isoalted trauma was found in 30 patients, epileptic seizure in 5, and physical exercise in 1 case. In 17 patients, besides alkohol consumption, trauma or epileptic seizure, the use of tranquilizers, anticonvulsants, or narcotic drugs was additonally noted. 78 patients developed ARF requiring dialysis therapy; 49 patients recovered, 5 required maintenance dialysis, and 30 died. Conclusions: During the initial phase of ARF in the course of rhabdomyolysis dynamic increases in serum urea and creatinine were observed, as well as a tendency to hyperkalemia. The treatment results and mortality rate in our study group were primarily influenced by the patients' general condition at admisssion, as well as the extent of organ damage caused by the primary etiological factor. Favorable treatment results were obtained especially in those patients who were hospitalized in a nephrological center, while the worst outcomes were noted in those patients dialyzed in intensive care units, most with multiple trauma.


    829/2523

    Tytuł oryginału: The influence of controlled hypotension on splanchnic mucosal perfusion using gastric tonometry in patients undergoing resection of meningioma.
    Autorzy: Pakulski Cezary, Nowicki Rafał, Kowalczyk Piotr, Bąk Piotr, Mikulski Krzysztof, Badowicz Beata
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR28-CR30, tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • anestezjologia
  • chirurgia
  • farmacja
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of our research was to evaluate the influence of general anesthesia with controlled nitroglycerin-induced hypotension on splanchnic mucosal perfusion using gastric tonometry. Material/Methods: In six patients (1 female, 5 males, median age 46 years, range 32 - 62) undergoing elective resection of meningiomas, measurements of gastric mucosal perfusion were taken by nasogastric tonometry. Controlled hypotension was initiated after craniotomy and terminated prior to hemostasis procedures. The mean arterial blood pressure (MAP) was maintained 25 - 30 p.c. below initial parameters during controlled hypotension. The adequacy of perfusion was defined by the intramucosal pH (pHi) and the difference between arterial and intramucosal pH (pHGAP). All parameters were analyzed before the induction of controlled hypotension, after the 1st, 2nd, and 3rd hour, and 1 hour after the termination of controlled hypotension. Results: The MAP decreased during controlled hypotension by ca. 26.5 p.c. (min. 21.1 p.c.; max 31.6 p.c.). The lower MAP was accompanied by a statistically significant increase in heart rate. A significant increase from baseline in regional prCO2 was seen after teh 1st, 2nd, and 3rd hour of controlled hypotension. Intramucosal pH values decreased significantly during the same period, from 7.428 ń 0.032 to 7.372 ń 0.015. Despite these statistically significant differences during controlled hypotension, the pH, values were always greater than 7.35, and the pHGAP values were lower than 0.05, which were recognized as being within the normal range. Conclusions: Controlled hypotension allows accurate evaluation of the blood flow quality at the level of microcirculation. Mild controlled hypotension slightly alters splanchnic mucosal perfusion.


    830/2523

    Tytuł oryginału: Prevalence of cryoglobulinemia in patients with chronic HCV infection.
    Autorzy: Liakina Valentina, Speiciene Danute, Irnius Algimantas, Naraskeviciene Jolanta, Barakauskiene Ausrine, Semuchiniene Teresa
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR31-CR36, tab., bibliogr. 31
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our research was to determine the prevalence of cryoglobulins in patients with chronic hepatitis C (CHC) at differnt levels of activity and stage of fibrosis and to identify their association with the extrahepatic clinical manifestations. Material/Methods: 87 patients with CHC were investigated for the presence of cryoglobulins. Cryocrit was measured by the Weiner method. Anti HCV, HCV RNR, conventional biochemical tests and liver biopsy were also performed. Results: Cryoglobulins were found in a total of 44 patients: 16 from Group I, II from Group II, and 17 from Group III. A low level of cryoglobulinemia (Cg) (cryocrit ó 2 p.c.) was detected in 16 patients: 9 from Group I, 3 from Group II, and 4 from Group III. Moreover, a high Cg (cryocrit 5 - 10 p.c.) or very high Cg (cryocrit 10 p.c.) was found in a total of 13 patients: 1 patient from Group I, 3 from Group II, and 9 from Group III. Cryo positivity was found in 5 patients with F 1 - 2, in 13 with F 2 - 3, in 4 with F 3 - 4, and in 17 with F 4. Conclusions: Our findings confirmed the high prevalence of Cg in CHC patients in Lithuania, a clear association between Cg and the stage of fibrosis, teh higher prevalence of Cg in cirrhotic patients, and the occurrence of several typical extrahepatic manifestations. The impact of Cg on the course of chronic hepatitis C is not clearly understood; therefore, further studies are needed to clarify this issue.


    831/2523

    Tytuł oryginału: Comparative study of early Lyme disease: Erythema migrans in New York State and Northeastern Poland.
    Autorzy: Zajkowska Joanna, Hermanowska-Szpakowicz Teresa, Coyle Patricia, Ostrowska Jolanta, Pancewicz Sławomir, Kondrusik Maciej
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR37-CR43, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The objeactive was to compare the clinical features of early local Lyme Disease: Erythema Migrans (EM) baeatween two highly endemic areas: New York State and Northeastern Poland. Study was based on self reporting questionnaires, physical examination, and laboratory results. Material/Methods: Group I (n = 27) consissted of citizens from New York State presenting with EM, referred to the study by their physicians. Group II (n = 25) consisted of patients treated as outpatients in 1998 - 1999 at the Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Poland. The diagnosis of EM was based on patient history and clinical picture. Results: Depending on the immune reaction of the host, the clinical picture is variabale. The initial symptoms range from discrete to strongly expressedd. The inflammatory reaction at the site of tick-bite seems to be milder in Europe than in North America, which is reflected in teh prevalence of the annular form of rash and milder expression of general symptoms. Mildor absent general symptoms and the prevalence of the annular over homogenous form are observed in those areas of Europe where Ixodes ricinus is the main veactor. In the endemic area of New York State, where Ixodes scapularis mainly occurs, uniform EM with fluplike symptoms is more common. Conclusions: There are distinct differences in the typical clinical picures between the two separated endemic areas of New York State and Northeastern Poland, due to different vectors (salive components?), bacaterial genospecies, likely intermediate hosts and clinatic differences. Familiarity with the presenting form of the disease can be very important, especially for primary care physicians.


    832/2523

    Tytuł oryginału: Extended-spectrum beta-lactamase-producing Enterobacteriaceae strains in community-acquired bacteremia in Southern Israel.
    Autorzy: Borer Abraham, Gilad Jacob, Menashe Galia, Peled Nechama, Riesenberg Klaris, Schlaeffer Francisc
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR44-CR47, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In recent years, extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have emerged in many hospitals worldwide. The increasing dissemination and long-term carriage of these organisms within the community carry tremendous implications on the empirical therapy of community-acquired infection. Material/Methods: To evaluate the prevalence and clinical features of community-acqured bacteremia involving ESBL-producing Enterobacteriaceae in sousthern Israel (ESBL-P) we retrospectively studied all Enterobacteriaceae bacteremias during an 8-month period in the Negev region using medical and laboratory records. Antibiotic susceptibility was determined using teh disk-diffusion method. ESBL production was determined using an E-test ESBL strip. Cases involving ESBL-P were compared to those involving non-producing strains (ESBL-NP) using the ch-square test. Results: In all, 187 Enterobacteriaceae bacteremias were de tected, of which 119 were community-acquired (63.6 p.c.). ESBL-P were found in sic cases (5 p.c.) which are d es c ribed herein in greater detail. Patients with ESBL-P bacteremia were older, and were more likely to stay in the intensive-care unit. Urinary catherterization and bed-ridden contidions were significant risk factorsfor ESBL-P. ESBL-P strains were significantly resistant to nearly all antibiotic agents except of imipienem and piperacillin-tazobaectam as opposing to ESBL-NP. Patients with ESBL-Pbacteremia were more likely to suffer from complications and had a higher mortality. Conclusions: This paper is the first to describe community-acquired Enterobaacteriaceae bacteremia involving ESBL-P strain in Israel. Although the exact prevalence of these organisms in Israel is currently unknown, our findings suggest that ESBL-producers have already begu to disseminate in our community.


    833/2523

    Tytuł oryginału: Significance of the evaluation of the tissue proliferation specific marker (TPS) and the carcinoembryonal antigen (CEA) in patients with ulcerative colitis and adenocarcinoma.
    Autorzy: Krauss Hanna, Ignyś Iwona, Kopczyński Zygmunt, Piątek Jacek
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR48-CR51, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: The aim of our research was to evaluate TPS concentration as a marker of proliferataive processes and the levels of CEA in children and adults with ulcerative colitis (UC) and in adults with colerctal adenocarcinoma (AC), to find out if there is any interdependence between TPS and C EA concentrations in these patients and to evaluate the usefulness of TPS as a marker of enoplastic risk in patients with UC. Material/Methods: The study was carried out in 3 groups of patients: Group I consisted of 15 children, ages 10 - 18, treated fro UC; Go;rup II, 22 adults, ages 23 - 40, treated for UC; and Group III, 14 patients, aged 40 - 60, in whom AC was diagnosed. Results: In Group II, the mean TPS concentration was significantly higher than in Group I (p 0.00001). In Group III, adults with AC, the mean TPS concentration was 1074.00 ń 1356.87 U/I. Thus there was a statistically significant difference between TPS concentrations in adults with UC and adults with AC (p 0.00005). THere was no statistically significant difference between CEA levels in children and adult groups with UC. However, a statistically significant difference occurrd between CEA concentrations in children and adults with UC and the group of adults with AC (p 0.00001). Conclusions: It would appear that testing for TPS concentration in patients with UC is helpful in monitoring the proliferative process, wheras in patients with neoplastic processes it serves as a screening examination, enabling early detection of recurrences, full evaluation of neoplastic growth, and evaluation of therapeutic effcectiveness.


    834/2523

    Tytuł oryginału: Detecting the replication of the hepatitis B virus using the ImmunoMax technique following treatment with Interferon-alpha in children with chronic hepatitis.
    Autorzy: Kasprzak Aldona, Wysocki Jacek, Zabel Maciej, Surdyk-Zasada Joanna
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.PR1-PR7, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Children with HBV in Poland are treated with preparations of interferon-alpha (IFN-ŕ). The continuing laack of complete response to this type of anti-viral therapy remains to be explained. The application of cell biology techniques to identify the viral components in situmakes it possible to clarify the association between the distribution of the virus and morphological injury to the liver, the immune response of the host, and clinical symptoms in the natural course of infection. Our study was intendent to evaluate HBV expression in liver biopsies taken an average of two years after completion of IFN-ŕ therapy in 10 children with serological markers of persistent HBV infection. Materil/Methods: For the immunocytochemical detecion of HBcAg and for the hybridocytochemical detection of HBV-DNA, the avidin-biotin-peroxidase (ABC) technique was employed, as well as classical in situ hybridization, both additionally amplified using the ImmunoMax technique. HBcAg and HBV-DNA levels were estimated using a semiquantitative technique. Resuslts: Our study demonstrated persistent active replication of HBV in the liver in all examined children. A mixed pattern of HBcAg localization prevailed (noted in cell nuclei, cytoplasm and cell membranes) with a somewhat lower proportion of involved cells and a more evident membrane localization of HBcAg, as compared to results obtained before treatment. HBVDNA was observed in the cytoplasm of a fraction of hepatocytes similar to that noted before therapy. Conclusions: The ImmunoMax technique was found to be highly suitable for in situ monitoring of HBV replication after termination of IFN-ŕ treatment. Children with focal distribution of HBcAg andHBV-DNA have the potential for earlier eradication of the virus from their livers.


    835/2523

    Tytuł oryginału: Chronic mesenteric ischemia: diagnosis and treatment with balloon angioplasty and stenting.
    Autorzy: Pietura Radosław, Szymańska Anna, El Furah Majda, Drelich-Zbroja Anna, Szczerbo-Trojanowska Małgorzata
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.PR8-PR12, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The goal of our research was to evaluate the efficacy of endovascular treatment in stenosis of the superior mesenteric artery and the celiac trunk. Material/Methods: During the period 1996-2001, 6 pateints (1 woman, 5 men, ages 46 to 73) were referred to our department with abdominal angina. Angiograms were performed in order to establish the reasons. All these patients presentedd with postprandial abdominal pain and weight loss. Angiography showed stenosis in the superior mesenteric artery in 2 patients, in the celiac trunk in 1 patient, and in both vessels in 3 patients. Typical balloon angioplasty (PTA) was performed with a balloon catheter, 5 - 8 mm in diameter, inflated up to 18 atm. If more than 30 p.c. stenosis remained after PTA, the patient was refered for stenting. Results: In 5 of the 6 patients (83 p.c.) PTA was successful. In one patient (17 p.c.) with poor results from PTA, a Perflex stent (diameter 7 mm) was inplanted in the superior mesenteric artery. The follow-up protocol included clinical and Doppelr ultrasonographic examination at 6, 12, and 18 months after surgery. A good clinical and ultrasound outcome was found in 6 patients at 6 and 12 months, and in 4 patients at 18 months. Conclusions: Balloon angioplasty and stent placement sem to be efficient and safe methods of treatment for abdominal angina in stenosis of the superior mesenteric artery and celiac trunk.


    836/2523

    Tytuł oryginału: Comparative study of cefaclor AF vs cefuroxime axetil in acute exacerbations of chronic bronchitis.
    Autorzy: Haczyński Józef, Chyczewska Elżbieta, Grzelewska-Rzymowska Iwona, Małolepszy Józef, Marcinowska-Suchowierska Ewa, Milanowski Janusz, Oklek Kazimierz, Płusa Tadeusz, Słomiński Marek, Szmygin Katarzyna, Rek Mirosław
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.PI1-PI7, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Acute exacerbations of chronic bronchitis (AECB) are the most common complication of chronic bronchitis. The majority of AECB are caused by infection. The choice of appropriate antibacterial therapy for AECB is becoming more difficult and is usually empirically, Cefaclor and cefruoxime are used for ambulatory treatment of AECB. Material/Methods: This multicenter, randomized, single blind study was undertaken in order to compare efficacy and safety of cefaclor AF (500 mg BID) and cefuroxime axetil (250 mg BID) in 10 days treatment of ambulatory patients with SECB. 170 adults were enrolled into the study. Clinical responses were assessed on 17th - 24th day after randomization. Results: Both antibiotics had high over 97 p.c. effectiveness in the treatment of AECB. There was stastically 1.7 times higher rate of patients with cough release after cefaclor treatment compared to cefuroxime (p 0.03). There was a significantly 2.25 higher rate of patients with AECB symptoms release like: increasing dyspnea, sputum volume and sputum purulence or cough in cefaclor group compard to cefuroxime (p 0.0187). Both treatment resulted in significant improvement of pulmonary peak expiratory flow (PEF). There were no differences between the rates of gastrointestinal and other side effects in both groups. Conclusions: 1. Cefaclor and cefruroxime have similar high efficacy and safety in 10 days treatment of patients with AECB. 2. Cefaclor treatment significantly higher 2.25 times reduces the rate of principle symptoms of AECB compared to cefuroxime. 3. Both antibiotics treatment significantly increase PEF, with higher tendency observed in after cefaclor treatment.


    837/2523

    Tytuł oryginału: Religious sensitivity pitted against the need to know: autopsy of Jewish children in Israel.
    Autorzy: Abraham Ron Ben, Weinbroum Avi A., Kassem Riad, Barzilay Zohar, Paret Gideon
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.SR1-SR4, bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to compare autopsy findings with antemortem findings in children who died in a pediatric intensive care unit. Material/Methods: Consecutive series of patietns who died in the pediatric intensive care unit during 2-year period were used. The study was conducted as a retrospective chart review at community, regional-referral, university-affiliated tertiary medical center of 1200 bed in Israel. Results: Permission was given to perform autopsies on only 10 children (23.8 p.c., mean age 85.7 months) out of the 42 who died during the study period. The mean length of stay in the pediatric intensive care unit prior to death was 13.3 days. Cardiac or hemato-oncologic diseases comprised the major pre-admission diagnoses. The autopsy revealed a major finding that, if known before death, would have altered clinical management in 50 p.c. of the patients: pneumonia, pneumonitis as well as intestinal perforation or necrosis. No correlation was found between patient length of stay in the intensive care unit and the autopsy disclosed information. Conclusions: Our findings suppert the importance of autopsy assessment in the pediatric intensive care setup. We beliewve that postmortem examination is also essential for improving the quality of pediatric patient care.


    838/2523

    Tytuł oryginału: Active and passive executive function disorder subsequent to closed-head injury.
    Autorzy: Pąchalska Maria, Kurzbauer Henryk, Talar Jan, MacQueen Bruce Duncan
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.CS1-CS9, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Executive dysfunction is one of the most destrucive sequelae of closed head injuries (CHI), often impeding or even preventing the patient's return to normal functioning. On the basis of extensive clinical testing of patients with neurobehavioral disturbances resulting from CHI, the authors propose a new typology of executive dysfunction based on the primary behavioral distinction between active ('acting without thinking') and passive ('thinking without acting') forms of executive function disorder. Material/Methods: Two patients were selected for detailed presentation. Both present with mild to moderate motor and cognitive symptoms resulting from closed head injury. The medical histories of the two patients are similar (educated professionals, mid-40s, married with children, injuries suffered in a traffic accident, 2 months in coma) except for the location of focal injuries. Results: Despite considerable progress in rehabilitation, the extent of functional disorder is disproportionately large in comparison to the degree of objective disability measured by standard instruments. It is suggested that the reason for this disparity lies in executive dysfunction. In particular, a model for executive functioning will be presented to explain why and low selective destruction of particular anatomical/functional components leads to the behvioral consequences known as 'executive dysfunction'. Conclusions: executive dysfunction is a distinct clinical syndrome which occurs in at least two distinguishable varieties, active and passive.


    839/2523

    Tytuł oryginału: The ' CARFEM' vascular index as a predictor of coronary atherosclerosis.
    Autorzy: Claessens Philip, Claessens Christophe, Claessens Marc, Claessens Maria, Claessens Jan
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.MT1-MT9, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of the study was detection of coronary atherosclerosis and identification of persons at risk by means of non-invasive examiantion of the carotid and peripheral arteries. Material/Methods: Investigation of 366 patients: 229 males and 137 females divided into groups according to age and the severity of the coronary atherosclerotic lesions. Only patients with a coronary stenosis of mor than 90 p.c., who needed angioplasty or coronary bypass surgery, were included. Group I consisted of patients with nromal coronary arteries; Gorup II, cirtical one-vessel disease; Group III, two-vessedl disease; Gorup IV, critical three-vessel diseases. By means of a vascular duplex scan we measured bilaterally the intima-media thickness of the posterior wall of the common carotid artery. In order to provide a more accurate estimation of the total atherosclerotic burden we have created the 'CARFEM' index (combination index of intima media thickness of carotid artery and total wall thickness of the superficial femoral artery). Results: The anthropometric data were identical among the different groups. There are statistically highly significantly differences in the intima-media thickness of the common carotid artery when patients with normal coronary arteries are compared with patients with three-vessel coronary disease. By calculating the 'CARFEM' index not only we can differntiate between patients with normal coronary arteries and patients with critical three-vessel disease, but there are also ways to differentiate between different subgorups and to assess possible one-vessel...


    840/2523

    Tytuł oryginału: Evaluation of the usefulness of the ELISA method for detection of enterovirus antibodies in serum samples of patients with myocarditis.
    Autorzy: Wielkopolska Anna, Gut Włodzimierz, Binduga-Gajewska Iwona, Jarząbek Zdzisław
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.MT10-MT14, il., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Enteroviruses are among the etiological factors in myocarditis, In the majority of cases it is impossible to obtain a direct confirmation of the presence of the virus, and typologically specific methods are of limited applicability, due both to the number of enteroviruses that can cause myocarditits, and to the serological cross reactions among them. The goal of our research was to determine the usability of the ELISA test and the complement fixation reaction (CFR) in diagnostic testing of the serum of patients with myocarditis. Material/Methods: The research material consisted of 1197 serum samples collected from patients with myocarditis. In all these samples we measured the contentration of IgG adn IgM enterovirus antibodies using the ELISA method, and teh height of the titer using the CFR method. Results: The presence of IgM antibodies is a confirmation of current infection. A postitive result was obtained for 61 p.c. of the patients. On the other hand, if one accepts as confirmation of infection a titer significantly different from the level observed in thy healthy population, namely ň 16 for CFR and ň 11 for ELISA-IgG (cf. positive results of 33 p.c. for CFR and 18.8 p.c. for ELISA IgG in our patients), the results may be disproportional. If one assumes as a test criterion a significant increase in titer, the presence of infection was confirmed in 28.5 p.c. of cases for CFR and 62 p.c. for ELISA-IgG. Conclusions: An analysis of the concentration of IgG antibodies constitutes a clear confirmation of infection., if the criterion of evaluation is based on a measure in a single serum sample. In this case it is necessary to test for a significant increase in the titer. The use of the average titer for the population at large to evaluate results leads to both false positives and false negatives. Testing for IgM antibodies in a single serum sample is a faster method which confirms the current presence of infection. Our results indicate that the ELISA test can be used to diagnose myocarditis, since


    841/2523

    Tytuł oryginału: Prediction of the biomechanical properties of cancellous bone using ultrasound velocity and bone mineral density - an in vitro study.
    Autorzy: Drozdowska Bogna, Pluskiewicz Wojciech, Przedlacki Jerzy
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.MT15-MT20, tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło
  • in vitro

    Streszczenie angielskie: Backgrouns: Recent experimental studies have suggested that the combination of DXA (dual energy X-ray absorptiometry) and ultrasound (US) measurements could improve the prediction of bone strength. The aim of this study was to investigate the ability of bone density and US velocity, measured by the phalangeal US system, to predict the Young's modulus and strength of cancellous bone. Material/Methods: 35 cubes of bovine cancellous bone from the distal radii were prepared using a dimond cutting saw. The US velocity (Speed of Sound - SoS [m/s]) was measured for the three orthogonal directions (proximal-distal -PD; anterior-posterior - AP; medial-lateral - ML) using a DBM Sonic 1200 device (Igea, Italy). Bone mineral density (BMD [g/cmý]) was measured by DXA, as well as the apparent volumetric BMD (v-BMD [g/cm**3], as the ratio of BMD to sample thickness). Young's modulus (E[MPa]) and ultimate strength (omikron[MPa]) were measured in the PD and AP directions by the uniaxial compressive test. Results: The SoS and biomechanical parameters were significantly higher (p 0.001) for the PD direction than for horizontal directions. In the PD direction, SoS, BMD adn v-BMD correlated significantly with E (r = 0.79 - 0.84, p 0.001) and omikron (r = 0.68 - 0.80, p 0.01). In the AP direction, SoS and v-BMD correlated significantly (r = 0.75 - 0.77, p 0.05) and BMD correlated almost significantly (r = 0.66, p = 0.05) with omikron, whereas their correlations with E were nonsignificant. In the PD direction, teh predictive value of SoS or bone density alone for E and omikron was generally...


    842/2523

    Tytuł oryginału: An assessment of the effectiveness of magnetic resonance imaging in delayed sequences after administration of Gd-DTPA contrast in the detection of metastatic lesions in the brain.
    Autorzy: Grzesiakowska Urszula, Tacikowska Małgorzata
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.MT21-MT24, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Advances in oncology in recent years have made it possible to undertake radical interventions even in advanced cases. Local treatment, surgical or radiosurgical, is applied ever more frequently in cases of metastases to the brain. This requires accurate determination of the number and location of metastases by means of imaging techniques. The goal of our research was to establish whether the use of sequences delayed by 20-30 minutes after gadolinium injection improves the number of metastatic lesions detected in the brain by MRI. Material/Methods: Twenty-eight patients were studied, ranging in age from 24 to 72 years, diagnosed with malignant tumors and suspected metastases to the brain. MRI examinations were performed with a 2T unit in SE T1 immediately after i.v. administration of a 0.1 mmol/kg does of gadolinium, and again 20 - 30 minutes after contrast injection; both sequences were done in axial projection in layers idenitcal as in the SE T1 sequence made befor gadolinium injection. The focal lesions were counted and classified by size. The number of detected lesions was calcualted in each group, comparing early and late phases after contrast injection. Results: The number of all nodules found in the delayed sequences was significantly higher in comparison to the early phase after gadolinium injection. Conclusions: Delayed sequence should be used to supplement basic sequences in the diagnosis of maignant metastases to the brain in selected oncological cases.


    843/2523

    Tytuł oryginału: Tonal nitric oxide and health - a free radical and a scavenger of free radicals.
    Autorzy: Benz Danielle, Cadet Patrick, Mantione Kirk, Zhu Wei, Stefano George B.
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.RA1-RA4, bibliogr. 68 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Basal/tonal nitric oxide (NO) production helps maintain particular microenvironments, i.e., vascular. Besides NO's function in controlling the activation state of various tissues such as immune cells, its presence appears to modulate other free radical levels, i.e., H2O2, in these same tissues and indeed these processes may be one and the same. Thus, by being a free radical, along with the ability to scavenge other free radicals. NO is placed in a pivotal regulatory position. We surmise that in the absence of adequate NO release other free radicals may go 'unchecked' and, therefore, initiate tissue damage. Furthermore, under these circumstances, proinflammatory events will occur due to heightened cell sensitivity and a diminished control of NF-kB. In an excess situation, and one without an appropriate cirucmstance, i.e., microbial acation, NO may baecome the harmful agent. Hence, balancing basal NO production in body compartments may represent a fundamental process in maintaining general, long-term health.


    844/2523

    Tytuł oryginału: Markers of inflammation and coronary artery disease.
    Autorzy: Saadeddin Salam M., Habbab Moh'd A., Ferns Gordon A.
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.RA5-RA12, tab., bibliogr. 154 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Many reaent experimental and clinical studies have provided evidence for the presence of inflammation in atherosclerotic lesions. Onging inflammatory reactions within coronary atherosclerotic plaques are increasingly thought to be crucial determinants of the clinical course of patients with coronary aertery disease (CAD). These facts lead to a search for reliable markers reflecting the inflammatory process in the atherosclerotic plaques. Circulating markers may consist of cytokines directly rleased from inflammatory cells present in the palques and tissues exposed to recurrent ischemia as well as other reactants produced in response to these cytokines such as adhesion molecules and acute phase proteins. Recent studies suggest that markers of inflammation may reflect different aspects of the atherothrombotic process at different points in the continuum of acute coronary syndromes, have a potential role for the prediction of risk for developing CAD, adn may correlate with severity and future risk for CAD. In spite of these findigns, the clinical utility of measuring these markers is limited by the availability of reproducible diagnostic test assays. In addition, it remains to be determined whether markers of inflammation actually have a causal relation with cardiovascular disease, or simply reflect the underlying disease proces. Such determination becomes important with the potential use of these markers in targeting preventive therapies. Therefore, further well-designed prospective evaluation of each of these markers is needed before their use in routine practice.


    845/2523

    Tytuł oryginału: Thrombolysis research - new objectives after a shift of accent.
    Autorzy: Maksimenko Alexander V.
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.RA13-RA21, il., tab., bibliogr. 76 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The methods of increasing the efficacy of thrombolysis under clinical and experimental conditions are have been discussed in the light of analysis of current tendencies in the investigation and development of thrombolytic and adjunctive therapy. Analysis of the data obtained in the search for novel plasminogen activators for thrombolytic enzyme therapy has shown a decrease and depletion of this search. The reserves for further increase in thrombolysis effciency have been notified. Special attention is paid to the purposes, realms and problems of adjunctive therapy, which is a promising breakthrough area in the effort of incrasing the efficacy of trhombolysis.


    846/2523

    Tytuł oryginału: Use of secretin in the treatment of childhood autism.
    Autorzy: Kamińska Barbara, Czaja Mariusz, Kozielska Ewa, Mazur Elżbieta, Korzon Maria
    Źródło: Med. Sci. Monitor 2002: 8 (1) s.RA22-RA26, bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • psychiatria i psychologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The paper presents current views concerning childhood autism. The authors present the concepts of etiology of this disorder, emphasizing the role of negative psychical stimuli in early childhood and the role of mother's contact with the child. Organic factors, including genetic background, developmental abnormalities of the nervous system, teratogenic factors and perinatal traumas are also taken into consideration. The role of metabolic factors and enterohormones, particularly thoses belonging to the secretin group and their effect on the function of the gastrointestinal tract and central nervous system is emphasized. We discuss signs which may be indicative of first symptoms of autism in different age groups. A typical symptom of autism is no development of speech, observed from infancy, taking the form of complete mutism at later stages. It has been emphasized that most pathologic symptoms result from altered perception of external stimuli, which arouse fear and anxiety. Autistic patients may suffeer from gastrointestinal tract disturbances such as abadominal pains and diarrhea. Methods used hitherto in the therapy of childhood autism, mainly by psychologists and psychiatrists, as well as some attempts of pharmcological treatment, are presented. The structure and function of secretin, as well as its effects on the motor and secretory function of the stomach and the exocrine function of the pancreas are discussed. The role of secretin in diagnostic tests, among others in the diagnosis of gastrinoma, is emphasized. We also present the history of the application of secretin in the therapy of childhood autism.


    847/2523

    Tytuł oryginału: Expression of TGF-á type I and II receptors in normal cancerous human endometrium.
    Autorzy: Piestrzeniewicz-Ulanska Dagmara, Brys Magdalena, Semczuk Andrzej, Jakowicki Jerzy A., Krajewska Wanda M.
    Źródło: Cancer Lett. 2002: 186 (2) s.231-239, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 306,023

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Transforming growth factor-á (TGF-á) belongs to a superfamily of structurally related polypeptides involved in various biological processes, including cell growth, proliferation and differentiation, angiogenesis, apoptosis, and extracellular matrix remodeling. We tried to define the different expression patterns of the TGF-á receptors by investigating the female reproductive organs during the menstrual cycle and endometrial tumorigenesis, because their role in these processes is still unclear. In this study, we examined the expression of the TGF-á type I and type II receptors in normal (n = 13) and carcinomatous (n = 42) endometrial tissue specimens using reverse transcriptase polymerase chain reaction and immunological (Western blot and enzyme linked immunosorbent assay) methods. Two uncommon female genital tract tumors, rhabdomyosarcoma of the uterine cervix and uterine carcinosarcoma, were also included. There were no significant differences between normal and cancerous endometrial tissues regarding the TGF-á receptors mRNA levels. However, we observed a markedly low TGF-á type I receptor protein level (P 0.028; Mann-Whitney-U test), while the malignant endometrium showed a significantly higher TGF-á type II receptor protein level (P 0.007; Mann-Whitney-U test) than the normal endometrium. Moreover, significantly elevated TGF-á receptor type II protein level was noted when depth of myometrial invasion of endometrial carcinomas was considered (P 0.05; Mann-Whitney-U test). In contrast to uterine carcinosarcoma, in which no detectable mRNA for TGF-á type II...


    848/2523

    Tytuł oryginału: The influence of a new vanadium compound, Bis(2,2'-bipyridine)oxovanadium(IV) sulphate on liver Golgi complexes from control and streptozotocin-diabetic rats.
    Autorzy: Kordowiak A. M., Dąbroś W., Kajda B.
    Źródło: Horm. Metab. Res. 2002: 34 (10) s.556-560, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 312,226

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Among the previously studied organic vanadium derivatives showing anti-diabetic action, we investigated a new complex, bis(2,2'-bipyridine)oxovanadium(IV) sulphate. We tested its ability to normalise parameters previously described for streptozotocin (STZ)-diabetes, such as lower yields of Golgi-rich membrane fraction isolation, decreased activity of Golgi membrane marker enzyme - galactosyltransferaze(GalT) - and altered morphology of rat liver Golgi complexes. Oral application as a drinking solution of 1,8 mmol bis(2,2'-bipyridine)oxovanadium(IV) (dissolved in 0.09 M NaCl) caused a similar dispersion of GalT activities in both vanadium treated groups, control and diabetic. Very low activities of the enzyme (characteristic for untreated diabetes) we found only in approximately 35 p.c. of the STZ-diabetic rats treated with the new vanadium compound. The morphology of liver Golgi complexes in diabetic rats treated with bis{2,2'-bipyridine)oxovanadium(IV) sulphate was improved, which manifested itself in the reappearance of vacuoles with VLDL and coated and uncoated secretory vesicles. In view of biochemical and morphological parameters of normalised diabetic rat liver Golgi apparatus, the new vanadium complex was more effective than bis(oxalato)oxovanadium(IV) or bis(kojato)oxovanadium(IV), but in our experimental model, the best anti-diabetic, orally applied drug was the bis(maltolato)oxovandium(IV) previously investigated.


    849/2523

    Tytuł oryginału: Carcinoembryonic antigen, squamous cell carcinoma antigen, CYFRA 2I-I, and neuron-specific enolase in squamous cell lung cancer patients.
    Autorzy: Kulpa Jan, Wójcik Ewa, Reinfuss Marian, Kołodziejski Leszek
    Źródło: Clin. Chem. 2002: 48 (11) s.1931-1937, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 304,722

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag), and CYFRA 21-1 are the most useful markers for non-small cell lung cancer (NSCLC), but neuron-specific enolase (NSE) is a tumor marker of choice for SCLC. The determination of NSE in NSCLC could allow selection of patients with neuroendocrine features. NSCLC patients whose tumors have neuroendocrine properties may be more responsive to chemotherapy; however, these tumors have been reported to be more aggressive. Tumor markers are not suitable for diagnosis; their principal applications are in monitoring of therapy and prognosis. Methods: Tumor markers were measured in 200 untreated patients with squamous cell lung cancer (SQC) and a reference group (n = 220; 124 healthy persons and 96 patients with nonmalignant lung disease). CEA and SCC-Ag were measured by microparticle enzyme immunoassays on Abbott AxSYM and IMx analyzers. CYFRA 21-1 and NSE were measured by electrochemiluminescence immunoassays on the Roche Elecsys 2010. Results: CEA, SCC-Ag, CYFRA 21-1, and NSE were increased above the cutoffs in 26 p.c., 32 p.c., 67 p.c. and 28 p.c. of tested patients, respectively. The area under the ROC curve for CYFRA 21-1 was higher than those for CEA, SCC-Ag, and NSE (SQC vs controls). CYFRA 21-1 and CEA were significantly higher in advanced SQC than in early stages of disease (P 0.0001 and P 0.0004, respectively). In multivariate analysis of survival, CYFRA 21-1 was an independent but nonspecific prognostic factor in the operable group of SQC patients, whereas NSE was an independent...


    850/2523

    Tytuł oryginału: Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir.
    Autorzy: Goslinski Tomasz, Golankiewicz Bożenna, De Clercq Erik, Balzarini Jan
    Źródło: J. Med. Chem. 2002: 45 (23) s.5052-5057, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 312,133

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: In search of strongly fluorescent tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2) derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-ŕ]purine system, several 6-[4-(acyloxy)-phenyl], 6-[4-(acylamino)phenyl], and 6-[4-(phenoxycarbonyloxy)phenyl]-substituted TACV and TGCV analogues were synthesized and evaluated for their activity against herpes simplex virus types 1 and 2 in cell culture. All TACV and TGCV analogues showed strong fluorescence (quantum yield of 30-65 p.c. vs 2-aminopurine 100 p.c.). The 6-[4-(phenoxycarbonyloxy)phenyl]-substituted compounds 11 and 19 displayed the best combination of the fluorescence and antiviral potency.


    851/2523

    Tytuł oryginału: Fatal outcome of a hypersensitivity reaction to paclitaxel: a case report.
    Tytuł polski: Śmierć pacjenta w wyniku wystąpienia reakcji nadwrażliwości na paklitaksel - opis przypadku.
    Autorzy: Kloover Jeroen S., Bakker Michael A. den, Meerbeeck Jan P. van
    Źródło: Współcz. Onkol. 2002: 6 (8) s.486, 488-489, bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 313,382

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • immunologia
  • onkologia
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie polskie: Paklitaksel jest powszechnie stosowany w leczeniu, m.in. raka jajnika, piersi oraz niedrobnokomórkowego raka płuc. Przed zaaplikowaniem leku należy go najpierw rozpuścić w substancji Cremophor EL, będącej pochodną oleju rycynowego. Zarówno sam paklitaksel, jak i jego rozpuszczalnik mogą wywoływać reakcje nadwrażliwości u leczonych tym lekiem chorych. Premedykacja polegająca na zastosowaniu kortykosteroidów może zapobiec wystąpieniu reakcji nadwrażliwości na paklitaksel. Powszechnie stosowany deksametazon jest długo działającym preparatem kortykosteroidowym, o okresie półtrwania wynoszącym ok. 48 godz. Lek ten hamuje reakcje zapalne, obniża stężenie mediatorów reakcji zapalenj, takich jak prostaglandyny i cytokiny oraz osłabia wrażliwość naczyń krwionośnych na czynniki o działaniu naczynioskurczowym. Przed rozpoczęciem leczenia paklitakselem stosuje się jeden z dwóch schematów premedykacji. Pierwszy z nich polega na doustnym podaniu 20 mg deksametazonu na 12 i 6 godz. przed rozpoczęciem każdego cyklu chemioterapii. Drugi, nie wymagający współpracy chorego, polega na dożylnym podaniu 5-20 mg deksametazonu bezpośrednio przed każdym cyklem. Pomimo tego, że pełna aktywność biologiczna deksametazonu pojawia się dopiero po kilku godzinach od jego podania, obie metody premedykacji uznawane są za równie skuteczne w zapobieganiu reakcjiom nadwrażliwości po podaniu Pakltakselu [2, 9, 11]. W niniejszym artykule opisano przypadek 52-letniego mężczyzny leczonego paklitakselem, u którego w górnym płacie lewego płuca wykryto naciekające śródpiersie ognisko raka niedrobnokomórkowego oraz liczne przerzuty w obrębie opłucnej...


    852/2523

    Tytuł oryginału: English language program : alumni 2002
    Opracowanie edytorskie: Kucharz Eugeniusz J. (ed.).
    Medical University of Silesia in Katowice
    Źródło: - Katowice, MUS 2002, 44 s. : il., 21x21 cm.
    Sygnatura GBL: 660,767

    Typ dokumentu:
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Śląska Akademia Medyczna w Katowicach


    853/2523

    Tytuł oryginału: Novel competitive PCR methods for quantitation of T-cell receptor delta (TCRD) gene rearrangements.
    Autorzy: Masternak Michał M., Przybylski Grzegorz K., Smoczkiewicz Paweł, Płotek Włodzimierz, Kowalczyk Dariusz W., Nowak Jerzy S.
    Źródło: J. Appl. Genet. 2002: 43 (2) s.235-244, il., tab., bibliogr. s. 242-244
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Since the invention of the polymerase chain reaction (PCR) several quantitative PCR-based approaches have been described. Recently, the real-time PCR method became a standard in quantitative PCR, althrough high costs of the necessary equipment and reagents make it unaffordable for many laboratories. In this paper we describe to novel competitive PCR techniques, which were used to determine the frequency of T-cell receptor delta gene (TCRD) rearrangements in peripheral blood leukocytes. In the referrence gene competitive PCR (rgc-PCR) the rearranged TCRD gene competes with the reference gene (RAG1) for common reagents (dNTPs and Taq polymerase). The intensity ratio of amplification products, TCRD/RAG1, corresponds to the portion of cells containing a rerrangement. A series of reactions was performed, in which RAG1 primers were added to the PCR after different numbers of cycles. On the basis of the number of cycles needs to obtain equal band intensity, the frequency of cells containing a rerrangement was calculated. In the common primer competitive PCR (cpc-PCR), two gene rearragements. Vë1-Jë1 and Vë2-Jë1, compete for the common Jë1 primer. The competing genes are amplified from the same genomic DNA template; therefore unlinke in the method using the internal competitor, the results are not affected by the quantity of quality of the analysed sample. We showed that the rgc-PCR and cpc-PCR are reliable ang give reproducible results. The methods do not require any expensive equipment or reagents, and can be used to determine the frequency of gene rearrangement.


    854/2523

    Tytuł oryginału: The KVLQT1 gene is not a common target for mutations in patients with various heart pathologies.
    Autorzy: Moric Ewa, Herbert Ernest, Mazurek Urszula, Samelska Justyna, Cholewa Krzysztof, Trusz-Gluza Maria, Wilczok Tadeusz
    Źródło: J. Appl. Genet. 2002: 43 (2) s.245-254, il., bibliogr. s. 253-254
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The long QT syndrome (LQTS) is a disorder of ventricular repolarization that exposes affected individuals to cardiac arrythmias and sudden death. The first gene for LQTS has been mapped to chromosome 11 p. 15.5 by genome-wide linkage analysis. This gene, originally named KVLQT1 (and later KCNQ1), is a novel potassium channel gene. Mutations in the human KVLQT1 gene, encoding the ŕ-subunit of the KVLQT1 channel, cause the long QT syndrome. In this work, we analysed the sequence of six KVLQT1 exons in patients with various heart pathologies. We describe 6 different mSSCP patterns with no disease-related SSCP conformes in any sample. Different sequencing of exons 2 to 7 confirmed the absence of mutations. This suggests that the analysed region of the KVLQT1 gene is not commonly involved in pathogenesis of the long QT syndrome.


    855/2523

    Tytuł oryginału: Variability of the human mitochondrial DNA control region sequences in the Lithuanian population.
    Autorzy: Kasperaviciute Dalia, Kucinskas Vaidutis
    Źródło: J. Appl. Genet. 2002: 43 (2) s.255-260, il., tab., bibliogr. s. 259-260
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca epidemiologiczna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The Lithuanians and Latvians are the only two Baltic cultures that survived until today. Since the Neolithic period the native inhabitants of the present-day Lithuanian territory have not been replaced by any other ethnic group. Therefore the genetic characterization of the present-day Lithuanians may shed some light on the early history of the Balts. We have analysed 120 DNA samples from two Lithuanian ethnolinguistic groups (Aukstaicail and Zemaiciai) by direct sequencing of the first hypervariable segment (HVI) of the control region of mitochondrial DNA (mtDNA) and restriction enzyme digestion for polymorphic site 00073. On the basis of specific nucleotide substitutions the obtained sequences were clasified to mtDNA haplogroups. The revealed the presence of almost all European haplogroups (except X) in the Lithumanian sample, including those that expanded through Europe in the Palaeolithic and those whose expansion ocurred during the Neolithic. Molecular diversity indices (gene diversity 0.97, nucleotide diversity 0.012 and mean number of pairwise differences 4.5) were within the range usually reported in European populations. No significant differences between Aukstaiciai and Zemaiciai subgroups were found, but some slight differences need further investigations.


    856/2523

    Tytuł oryginału: Immunotherapy of cancer through targeting of the p53 tumor antigen.
    Autorzy: Zwaveling Sander, Burg Sjoerd H. van der, Menon Anand G., Melief Cornelis J. M., Offringa Rienk
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.297-305, il., bibliogr. 75 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The expression of the p53 tumor suppressor protein is frequently increased in a great variety of human cancers, making this antigen an attractive candidate for targeting therapeutic T cell immunity. However, potential complications as a result of immunological tolerance or autoimmune pathology must be taken into account when exploiting this ubiquitously expressed auto-antigen for the immunotherapy of cancer.


    857/2523

    Tytuł oryginału: Lymphocyte distribution and intrahepatic compartmentalization during HCV infection: a main role for MHC-unrestricted T cells.
    Autorzy: Agrati Chiara, Nisii Carla, Oliva Alessandra, D'Offizi Gianpiero, Montesano Carla, Pucillo Leopoldo Paolo, Poccia Fabrizio
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.307-316, il., bibliogr. 103 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Hepatitis C virus (HCV) infection induces an acute and chronic liver inflammation through an immune-mediated athway that may lead to cirrhosis and liver failure. Indeed, HCV-related hepatitis is characterized by a dramatic lymphocyte infiltrate into the liver which is mainly composed by HCV non-specific cells. Several data indicated that interferon (IFN)-ç secretion by intrahepatic lymphocytes 9IHL) may drive non-specific cell homing to the liver, inducing interferon inducible protein-10 9p-10) production. An interesting hallmark of these IHL is the recruitment of lymphocytes associated with mechanisms of innate immunity, such as natural killer (NK), natural killer T (NKT) and çë T lymphocytes. CD81 triggering on NK cell surface by the HCV envelope glycoprotein E2 was recently shown to inhibit NK cell function in the liver of HCV-infected persons, resulting in a possible mechanism contributing to the lack of virus clearance and to the establishment of chronic infection. In contrast, intrahepatic NKT cells restricted to CD1d molecules expressed on the hepatocyte surface may contribute to a large extent to liver damage. Finally, an increased frequency of T cells expressing the çë T cell receptor (TCR) was observed in HCV-infected liver and recent observations indicate that intrahepatic çë T cell activation could be directly induced by the HCV/E2 particle through Cd81 triggering. These cells are not HCV specific, are able to kill target cells including primary hepatocytes and their ability to produce T helper (Th)1 cytokines is associated with a higher degree of liver disease...


    858/2523

    Tytuł oryginału: Immunotherapy in the management of sepsis.
    Autorzy: Sikora Janusz Piotr
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.317-324, bibliogr. 65 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: This work presents the role of Gram-negative bacteria endotoxins, pro- and anti-inflammatory cytokines and reactive oxygen species (ROS) in the complex and not fully explained pathogenesis of sepsis. The so-called "respiratory burst" of neutrophils and the antioxidant mechanisms of the host are also discussed. The work focuses on possible approaches to the management of sepsis connected with immunotherapy. Neutralization of endotoxin lipopolysaccharide (LPS), anti-tumor necrosis factor ŕ (TNF-ŕ) therapy with monoclonal antibodies or pentoxifylline (PTXF), as well as soluble recombinant cytokine agonists and antagonists used in clicnial trials are taken into consideration. In addition, cytokine manipulation therapy, anti-adhesion techniques, glucocorticoides and antioxidant barrier interference are also described. So far there has been no immunotherapy of sepsis in children of proven clinical efficacy, which promts an aggressive examination of the immune system aimed at affecting its function.


    859/2523

    Tytuł oryginału: The role of TGF-á signaling in the pathogenesis of fibrosis in scleroderma.
    Autorzy: Ihn Hironobu
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.325-331, bibliogr. 86 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs is a hallmark of systemic sclerosis (SSc). The pathogenesis of SSc is still poorly understood, but increasing evidence suggests that transforming growth factor (TGF)-á is a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathological states such as systemic sclerosis. TGF-á regulates diverse biological activities including cell growth , cell death or apoptosis, cell differentiation, and ECM synthesis. TGF-á is known to induce the expression of ECM proteins in mesenchymal cells and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. This review focuses on the possible role of TGF-á in the pathogenesis of fibrosis in SSc.


    860/2523

    Tytuł oryginału: The protective role of the HLA-DR locus in patients with various clinical types of alopecia areata.
    Autorzy: Broniarczyk-Dyła Grażyna, Prusińska-Bratoś Magdalena, Dubla-Berner Małgorzata, Arkuszewska Celina, Borowiec Maciej, Kowalski Marek L., Woszczek Grzegorz
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.333-336, tab., bibliogr. 18 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • pediatria
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: One of the genetic factors associated with the development of alopecia areata (AA) is the HLA locus. The study comprised 52 patients with AA aged 10 to 64 years. The frequences of HLA-DRB alleles in the patients and controls were compared. The control group comprised 152 healthy persons. Familia occurrence of AA was seen in 7 (13.5 p.c.) cases. A significantly lower frequency of HLA-DRB1*03 was observed in patients with AA comparison with the control group. In all patients with AA, alleles HLA-DRB1*15/*16 occurredd more frequently than in the control group, but this was not significant after correction. In the group of patients with more severe forms of alopecia areata (alopecia areata totalis/alopecia areata universalis) there was no signficant difference in HLA-DR allele distribution.


    861/2523

    Tytuł oryginału: The lack of relationship between serum content of MBL, sCD14, Anti-PPD and Anti-Hsp65 IgG and ingestion of Mycobacterium bovis BCG bacilli by phagocytes.
    Autorzy: Paziak-Domańska Beata, Bonar Agnieszka, Kowalewicz-Kulbat Magdalena, Klink Magdalena, Kowalski Michał, Karhukorpi Jari, Karittunen Ritta, Jurkiewicz Magdalena, Różalska Barbara, Rudnicka Wiesława
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.337-344, il., bibliogr. 28 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Prophylactic vaccination against tuberculosis (TB) with a live attenuated strain of Mycobacterium bovis bacille Calmette-Gu‚rin (BCG) has been used worldwide. However, TB remains one of the most significant diseases of humans and animals. Better understanding of the mechanisms of human immunity to mycobacteria is essential for the development of new vaccines and the estimation of their efficacy. In this study we determined the levels of known humoral mediators of mycobacterial phagocytosis, i.e. mannose-binding lectin (MBL), soluble CD14 (sCD14), antibodies of the immunoglobulin G (IgG) class against mycobacterial purified protein derviative (PPD), and mycobacterial Hsp65 antigen, in the sera from healthy young volunteers vaccinated with BCG and presenting positive and negative Mantoux responses to PPD. Then we asked the question as to whether macrophages and polymorphonuclear leukocytes (PMNs) from the individuals with postiive tuberculin test (TT(+)) and negative tuberculin test (TT(-)) differed in their ability to ingest mycobacteria. We also looked for a relationship between the intensity of mycobacterial ingestion by phagocytes in a medium of autologous sera containing different concentrations of MBL, sCD14 and anti-mycobacterial IgG. We found no significant differences between the investigated paraemters for TT(+) and TT(-) volunteers. Our result suggest that the ability of macrophages and PMNs to ingest mycobacteria depends on an individual, intrinsic capacity of the phagocytes.


    862/2523

    Tytuł oryginału: Structural and serological characterization of the lipopolysaccharide from Proteus penneri 20 and classification of the cross-reacting Proteus penneri strains 10, 16, 18, 20, 32 and 45 in Proteus serogroup O17.
    Autorzy: Sidorczyk Zygmunt, Toukach Filip V., Zych Krystyna, Arbatsky Nikolay P., Drzewiecka Dominika, Ziółkowski Andrzej, Shashkov Alexander S., Knirel Yuriy A.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (5) s.345-350, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: O-specific polysaccharide (O-antigen) of the lipopolysaccharide of Proetus penner 20 was studied using sugar analysis along with various one- and two-dimensional NMR spectroscopy techniques. The following structure of the polysaccharide was established: (...). It has the same carbohydrate backbone structure as that described earlier for P. penneri 16, in which the positions of the O-acetyl groups habe not been determined. P. penneri 20 O-antiserum showed a strong cross-reactivity with the lipopolysaccharides of P. penneri 10, 16, 18, 32, 45 and P. mirabilis O17. These data enable classifying these strains together with P. penneri 20 in one Proteus serogroup, O17.


    863/2523

    Tytuł oryginału: Benefits and menaces related to the use of statins in patients after renal transplantation.
    Autorzy: Chmielewski Michał, Zdrojewski Zbigniew, Rutkowski Bolesław
    Źródło: Ann. Transplant. 2002: 7 (2) s.6-10, il., tab., bibliogr. 60 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • nefrologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Hypercholesterolemia in patients after renal transplantation composes a signifcant risk factor of cardio-vascular disease, it may also worsen graft survival. Statins are the most potent drugs to lower blood cholesterol. They also posses numerous pleiotropic abilities. The paper presents benefits of the use of statins in patietns after renal transplantation, as well as the dangers related to the side effects of these drugs. It underlines that adequate use of statins is worth considering in patients after renal transplantation, taking into account not only their abilit to lower cholesterol but also their additional properties positively influencing graft survival.


    864/2523

    Tytuł oryginału: Atrial resynchronization in patients after heart transplantation.
    Autorzy: Kutarski Andrzej, Zakliczyński Michał, Oleszczak Krzysztof, Kuśnierz Jacek, Lech Bogdan, Wojarski Jacek, Kalarus Zbigniew, Przybylski Roman, Widomska-Czekajska Teresa, Religa Zbigniew, Zembala Marian
    Źródło: Ann. Transplant. 2002: 7 (2) s.11-17, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Lower-Shumway technique (atrioatrial anastomosis) is the most frequently used technique for orthotopic heart transplantation and such a patient has two right atria and two sinus nodes. Sinus node dysfunction (SND) is a frequent finding in pts. after OHT; taking advantage of the frequency of innervated sinus node of recipient's atrial remnant as a natural biosensor for triggered pacing of donor atrium is an interesting option for these pts. The aims of our study: 1. the analysis of possibility of utility of recipient atrial sinus node as natural biosensor for triggered donor atrium permanent pacing in transplanted patients with SND. 2. the evaluation of pacing and sensing conditions of the recipient's atrium in the some pts. 3. long-term observation of effectiveness A2A2T(/D) pacing mode. Methods. 10 out of 37 pts. received A2A2T (8 pts.) and A2A2T/D (2 pts) pacing systems. In pts. with NSR of recipients atrium, we evaluated acceleration of its frequency during slight exercise and atropine. Results. In recipient's atrium among 37 pts we recognized NSR only in 15/37 pts.; in the remaining 22 pts. we found: sinus bradycardia - in 3, atrial flutter - in 3, low voltage AF - in 12 and no electrical activity - in 4 pts. Positive response to isometric exercise and atropine was observed in 12/15 pts. and 8 of them received A2A2T or A2A2T/D pacing system. We found much better sensing and pacing conditions in donor (A wave 2,1 mV, p. threshold 0,8 V) than in recipient atrium (1,1 mV and 1,4 V respectively)...


    865/2523

    Tytuł oryginału: Atrial pacing of transplanted heart.
    Autorzy: Kutarski Andrzej, Zakliczyński Michał, Oleszczak Krzysztof, Wojarski Jacek, Foremny Jerzy, Kuśnierz Jacek, Jaworska Maria, Puszczewicz Dariusz, Łakomski Bogdan, Kalarus Zbigniew, Religa Zbigniew, Widomska-Czekajska Teresa, Zembala Marian
    Źródło: Ann. Transplant. 2002: 7 (2) s.18-27, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Orthotopic heart transplantation (OHT) is most effective method for treatment of irreversible heart failure. Pateitns after OHT considered for permanent pacing consist still present a challenge for the implanting physician due to distorted atrial geometry and specific electrophysiological conditions of atrium. The aim of our study was to analyse the effectiveness of permanent atrial pacing in these patients. Patients and method. We implanted atrial lead in 37 SND pts., 2 months - 7 years after OHT, (3 pts with coexisting AV block received ventricular lead). Only straight BP screw in leads and manually formed stylets were used; we found satisfactor pacing/sensing conditions in 25 pts in RA appendage or anterior/lateral wall, in 10 pts - in CS ostium region and in 2 - in proximal part of CS. Results. Allimplantations were successful and no patient received WI pacing system. One dislodged lead required revision (1/37, 3 p.c.) but this was not related to endomyocardial biopsy. In 2 pts, due to nacceptable low RA potential and/or high PTh values atrial lead was implanted to CS for sensing/pacing of left atrium. The average acute value of A wave were 2,4 mV and chronic 2,2 mV; values of pacing threshold were 0,9 V and 1,6 V respectively. Only in 13/37 pts native A waves were recorded but with amplitude 0,6 mV. Wenckebach point was 120/min only in 2 pts., in borders 130-160 bpm in 15 pts. and exceeded 170 bpm. in remained 20 pts. Retrograde VA conduction was intact in 33/37 pts, but in 4 pts exceeded 260/min...


    866/2523

    Tytuł oryginału: Effect of L-arginine on oxygen consumption and haemodynamic function of rat's heart exposed to cold cardioplegic ischaemia and reperfusion.
    Autorzy: Okoński Piotr, Szram Stefan Mirosław, Mussur Mirosław, Banach Maciej, Fila Michał, Bielasik Karol, Kędziora Józef, Zasłonka Janusz
    Źródło: Ann. Transplant. 2002: 7 (2) s.28-31, il., bibliogr. 17 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Ischaemia - reperfusion damage causes injury of all heart cells. Loss of endothelium function and biologically active substances secreted by it can be essential to development of the damage. Ischaemia and reperfusion decreases the release of nitric oxide, which influences postischaemic coronary flow and return of ventricular function. Administration of L-arginine to cardioplegic and reperfusion solution can improve protection of heart and cause the return of left ventricular function after hypothermic ischaemia through preservation of endothelial cell functions and increase of release of nitric oxide. Objective: How addition of L-arginine to cardioplegic solution influences oxygen consumption by myocardium and its postischaemic haemodynamic function. Methods: The research was conducted on isolated heart model of 56 rats, divided into seven equal groups. The hearts were prepared with modified Neely method and were perfused with the use of apparatus in accordance with modified Langendorf method. The research was carried out in the following order: initial perfusion of the non-working and working heart, perfusion with cardioplegic solution, cold cardioplegic arrest and reperfusion of the non-working and working heart. Results: During initial perfusion, oxygen consumption was comparable in all groups. During cardioplegic perfusion, oxygen consumption was reduced in every group. At the time of reperfusion of non-working heart model, consumption of oxygen was increased. During reperfusion of the working heart, the lowest oxygen consumption was noted in group P, the highest in group DI...


    867/2523

    Tytuł oryginału: Pituitary function test and endocrine status in patient with cirrhosis of the liver before and after hepatic transplantation.
    Autorzy: Seehofer Daniel, Steinmueller Thomas, Graef Klaus-Juergen, Rayes Nada, Wiegand Wolfgang, Tullius Stefan G., Settmacher Utz, Neuhaus Peter
    Źródło: Ann. Transplant. 2002: 7 (2) s.32-37, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • endokrynologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective: Hormonal alterations caused by chronic liver disease are well described. In contrast, the reversibility of peripheral hormonal changes after orthotopic liver transplantation (OLT) has only partially been analyzed since the establishment of OLT as treatment of chronic hepatic failure. In addition it is not finally verified if chronic liver failure and especially hepatic encephalopathy also affect ituitary function. We therefore performed extensive endocrine studies including a global pituitary stimulation test before and after liver transplantation. Methods: 22 patients with chronic alcoholic and non alcoholic liver failure were included in this prospective study. Basal hormone values (ACTH, cortisol, FSH, GH, IGF-I, LH, oestradiol, PRL, thyroid hormones and testosterone) were measured before and up to 5 years after OLT. Furthermore all patients underwent pituitary function tests with application of GRF, TRH, GnRH, and CRF before, 3 weeks and 3 months after OLT. Results: Estratiol, LH and FSH increased significantly in postmenopausal and only slightly in premenopausal female patients after OLT. Total testosterone revealed no marked changes and was normal before and up to five years after OLT in male patients. After stimulation with GnRH the LH response in females and the FSH response in males was significantly higher three months after OLT than pretransplant. LH response in males and FSH response in females was only slightly higher after OLT. Peripheral IGF-I was low and growth hormone was elevated in all patietns prior OLT...


    868/2523

    Tytuł oryginału: High intensity regimens with autologous hematopoietic stem cell transplantation as treatment of multiple myeloma.
    Autorzy: Awedan Abdulnaser A.
    Źródło: Ann. Transplant. 2002: 7 (2) s.38-43, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • onkologia
  • transplantologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The treatment of multiple myeloma still remains under investigation. Conventional chemotherapy with currently used agents (i.e., Melphalan) effects complete remission in no more than 5 p.c. of patients. High dose chemotherapy followed by hematopoietic stem cells transplantation results in complete remission rates between 25 p.c. and 75 p.c. and a 3-year probability of event-free survival between 40 p.c. and 60 p.c. but is not curative since most patients relapse after 1.5 to 3 years. Therefore, it becomes the treatment of choice for multiple myeloma. The drugs used in high dose therapy include: high dose melphalan (200 mg/mý) as single agent., melphalan (140 mg/mý) and total body irradiation (TBI), busulfan and melphalan... etc. The use of the peripheral blood stem cell transplantation has allowed a reduction in the toxicity of high-dose regimens, but has not led to an increase in the overall response rate or survival. Hematopoietic stem cells from peripheral blood are preferred for transplantation because they restore hematopoiesis more rapidly than do bone marrow cells and the numbers of tumor cells are lower in peripheral blood than bone marrow cells. Peripheral blood stem cell transplantation was associated with significant reduction in the duration of aplasia and transfusion requirements. Several regimens have been proposed for stem cells mobilization including: High-dose cyclophosphamide and G or GM-CSF, G-CSF alone, and cyclophosphamide and etoposide with G-CSF... ect. Further attempts to improve the results of autotransplantation have included intensification with tandem translantation (double transplants) and reduction of tumor cells in stem cell infusion...


    869/2523

    Tytuł oryginału: First kidney transplantation from a non-heart-beating donor in the Czech Republic.
    Autorzy: Treska Vladislav, Hasman Daniel, Reischig Tomas, Certik Bohuslav, Cechura Milos, Racek Jaroslav, Trefil Ladislav, Hes Ondrej
    Źródło: Ann. Transplant. 2002: 7 (2) s.45-49, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The long-lasting decline in the number of kidney donors with brain death in recent years is the reason for a quest for new sources of kidney donors in the Czech Republic. One possible source to increase the number of donor kidneys is the program of obtaining kidneys from non-herat-beating donors (NHBDs). Based on previous experience abroad, optimum hospital conditions, and, first of all, three years of experimental work it was possible to realise an NHBD program for the first time in the Czech Republic, in the Transplant Centre of the Plzen Hospital in early 2002. The first two kidneys were obtaiend from a donor with a devastating gunshot brain injury (maastricht criteria, Class III). After machine perfusion (RM3 renal perfusion system, Waters Medical) both kidneys were transplanted into two recipients with chronic renal insufficiency (chronic glomerulonephritis, nephrosclerosis). Both kidneys resumed their function immediately. For immunosuppression, basiliximab (Simulect, Novartis), rapamycin (Rapamune, Wyeth), and methylprednisolone (Urbason solubile forte, Hoechst) were used. To improve renal function, cyclosporine A (sandimmune Neoral, Novartis) was started later in the course, simultaneously reducing the dose of rapamycin. The postoperative course was uneventful and both patients could be discharged on the twenty-first day of hospitalisation for further care at home.


    870/2523

    Tytuł oryginału: Prolongation of rat kidney graft survival after inoculation of allogeneic spleen cells: the effect of various routes of cell transfer.
    Autorzy: Oko Andrzej, Idasiak-Piechocka Ilona, Pawlaczyk Krzysztof, Wruk Michał, Pawliczak Elżbieta, Czekalski Stanisław
    Źródło: Ann. Transplant. 2002: 7 (2) s.51-53, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Objectives: It has been clearly demonstrated that after donor-specific cell transfer the prolongation of allograft survival can be obtained, but the problem of how to inoculate cells remains unresolved. In this study, the effect of either protal venous (PV) or systemic intravenous (IV) inoculations of rat donor-specific spleen cells on subsequent renal graft survival was evaluated. Methods: LEW recipients received 10**6 of spleen cells from allogeneic Fishcer or syngeneic donors 30 days before kidney transplantation by either PV or IV routes. Animals from the control group obtained buffered saline by the same routes. Results: Fischer grafts in nonimmunized LEW recipients were rejected after 9.6 ń 1.3 days. In contrast, the immunization of the recipients by the pretreatment with donor spleen cells prolonged renal allograft survival significantly (p 0.002). However, no difference in the graft survival was observed between animals ioculated with cells either by PV or by IV routes. In each studied group, long-time graft survival ( 100 days) was achieved in one case. Conclusions: These observations suggest that the effect of the various routes of allogeneic cell inoculations on subsequent organ graft survival time depends on the interval between the cell transfer and organ transplantation. Intravenous route seems to be as effective as PV route when transplantation is performed several days after donor-specific cell transfusion.


    871/2523

    Tytuł oryginału: Inhibiton of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IkB/NF-kB-sensitive pathway in the alveolar epithelium.
    Autorzy: Haddad John J., Safieh-Garabedian Bared, Saad‚ Nayef E., Lauterbach Ryszard
    Źródło: Int. Immunopharmacol. 2002: 2 (11) s.1567-1583, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 313,577

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The regulation of lipopolysaccharide (LPS)-mediated pro-inflammatory cytokine biosynthesis by reduction by reduction-oxidation (redox)-sensitive enzymes involved in maintaining intracellular glutathione homeostasis was onvestigated in fetal alveolar type II epithelial cells (fATII). Inhibition of glutathione-oxidized disulfide reductase, which recycles GSSG - 2GSH, by the action of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) augmented LPS-depenfent secretion of interleukin (IL)-1á, IL-6 and tumor necrosis factor (TNF)-ŕ. BCNU incresed [GSSG] concentration at the expense of [GSH], thereby favoring oxidation equilibrium. Inhibition of ç-glutamylcysteine synthetase, the rate-limiting enzyme in the biosynthesis of GSH, by the action of L=buthionine-(S,R)-sulfoxime (BSO), potentiated LPS-induced IL-1á, IL-6 and TNF-ŕ production. Similar to BCNU, BSO depleted [GSH] and induced the accumulation of [GSSG]. BCNU and BSO reduced LPS-mediated phosphorylation of inhibitory-kB (IkB-ŕ), allowing its cytosolic accumulation. This effect was associated with the inhibition of the nuclear translocation of selective nuclear factor (NF)-kB subunits: NF-kB1 (p50), RelA (p65), RelB (p68) and c-Rel 9p75), but not NFkb2 (p52). BCNU and BSO reduced LPS-induced NF-kB activation as determined by the electrophoretic mobility shift DNA-binding assay. Analytical analysis of the effect of modulating the dynamic redox ratio [GSH]+[GSSG])[GSSG] revealed a novel role for GSSG as a disulfhydryl compound which an inhibitory effect on NF-kB activation. In is concluded that selective modulation...


    872/2523

    Tytuł oryginału: Bone turnover markers and cytokines in joint fluid. Analyses in 10 patients with loose hip prosthesis and 39 with coxarthrosis.
    Autorzy: Sypniewska Grażyna, Lis Kinga, Biliński Piotr J.
    Źródło: Acta Orthop. Scand. 2002: 73 (5) s.518-522, il., tab., bibliogr. [27 poz.]
    Sygnatura GBL: 301,078

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We analyzed bone turnover markers (osteocalcin, bone ALP, á-crosslaps-CTX) and cytokines (IL-1, IL-8 and IL-10) in hip joint fluid in 10 patients before revision surgery and in 39 with idiopathic coxarthrosis. patients with loose imlants had lower concentrations of resorption marker than those with arthrosis (0.8 vs 1.3 ng/mL), but bone formation marker osteocalcin was reduced (4.2 vs 22.6 ng/mL). IL-8 and IL-10 levels were elevated in patients with implant failure (870 vs 340 pg/mL; 14,3 vs 4.0 pg/mL). We found a negative correlation between the bone resorption marker (CTX) and IL-10 in cases with prosthesis loosening and a positive correlation between IL-10 and time-to-revision. We conclude that enhanced local production of inflammatory cytokines leading to supressed bone formation is a part of the loosening process. The expression of anti-inflammatory mediators is not sufficient to counteract the imbalance in bone turnover.


    873/2523

    Tytuł oryginału: Changes of propofol concentration in cerebrospinal fluid during continuous infusion.
    Autorzy: Dawidowicz Andrzej, Kalityński Rafał, Nestorowicz Andrzej, Fijałkowska Anna
    Źródło: Anesth. Analg. 2002: 95 (5) s.1282-1284, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,042

    Hasła klasyfikacyjne GBL:
  • anestezjologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We studied the changes in the propofol concentration in the cerebrospinal fluid (CSF) in 14 patients, undergoing elective intracranial procedures, who were anesthetized with propofol administered by target-controlled infusion. During anesthesia, fentanyl and cisatracurium were administered as required. After intubation of the trachea, the lungs of the patients were ventilated to normocapnia with an oxygen-air mixture (Fio2 = 0.33). Arterial blood and CSF samples (from an intraventricular drain) were collected between 90-180 min after the induction of anesthesia. Blood propofol concentrations were stable, between 5.0 ń 1.98 and 4.5 ń 1.7 ćg/mL (mean ń sd). There was a significant decrease in the CSF propofol concentration, from 52.2 ń 35.01 ng/mL at 90 min to 28.6 ń 21.9 ng/mL min (P 0.05). The CSF propofol concentration at 180 min (21.4 ń 14.9 ng/mL) was not significantly different from the concnetration at 150 min. Some possible reasons for this decrease after commencing continuous intraventricular drainage are discused.


    874/2523

    Tytuł oryginału: A phase III placebo-controlled study in advanced head and neck cancer using intratumoural cisplatin/epinephrine gel.
    Autorzy: Werner J. A., Kehrl W., Płużańska A., Arndt O., Lavery K. M., Glaholm J., Dietz A., Dyckhoff G., Maune S., Stewart M. E., Orenberg E. K., Leavitt R. D.
    Źródło: Br. J. Cancer 2002: 87 (9) s.938-944, tab., bibliogr. 24 poz.
    Sygnatura GBL: 301,683

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Patient with recurrent or refractory head and neck squamous cell carcinoma received cisplatin/epinephrine injectable gel or placebo gel injected directly into the clinically dominant tumour. The double-blind phase III trial comprised of up to 6 weekly treatments over 8 weeks, 4 weekly evaluation visits, and then monthy follow-up; open-label dosing began as needed after three blinded treatments. Tumour response was defined as complete (100 p.c. regression) or partial (50-99 p.c. regression) sustained for ň28 day, and patient benefit as attainment of paliative or preventive goals prospectively selected by investigators and patients. With cisplatin/epinephrine gel, 25 p.c. (14 out of 57) of tumours responded (16 p.c. complete regression, 96 partial regression), vs 3 p.c. (one out of 35, complete regression) with placebo (P = 0.007). Patient benefit was positively associated with target tumour response in the blinded period among cisplatn/epinephrine gel recipients (P = 0.024): 43 p.c. (six out of 14) of responders benefited, vs 12 p.c. (five out of 43) of non-responders. the most frequent adverse event was pain during injection and the next most frequent was local cytotoxic effects consistent with the gel's mode of action. systemic adverse events typical of intravenous cisplatin were uncommon. Intratumoral therapy with cisplatin/epinephrine gel provided safe, well-tolerated, effective palliative treatment for patients with locally advanced head and neck squamous cell carcinoma, who lack other satisfactory treatment options.


    875/2523

    Tytuł oryginału: Antagonists of platelet fibrinogen receptor are less effective in carriers of P1a2 polymorphism of á3 integrin.
    Autorzy: Różalski Marcin, Watała Cezary
    Źródło: Eur. J. Pharmacol. 2002: 454 (1) s.1-8, il., tab., bibliogr. [41] poz.
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The polymorphism Leu33 - Pro (platelet-specific antigen; P1a1/a2) of platelet GPIIIa is a potential risk factor for arterial thrombosis. However, its influence on platelet function remains controversial and little is known about its impact on platelet sensitivity to GPIIb-IIIa antagonists. Our objective was to ompare the effectiveness of various GPIIb-IIIa antagonists in P1a2(+) and P1a2(-) carriers. Platelet aggregation was monitored in healthy donors including P1a2(-) (N = 31) and P1a2(+) subjects (N = 27; 23 P1a1/a2, 4 P1a2/a2) using the impendance and turbidimetric aggregation tecniques. We evaluated the inhibition of ADP- and collagen-induced aggregation by disintegrins, kistrin and echistatin, and the low-molecular-weight blockers, GR144053F ((4-[-[4-(aminoiminomethyl]-1-piperazinyl]-1-piperidineacetic acid, hydrochloride trihydrate) and eptifibatide (N6-(aminoiminomethyl)-N2-(mercaptol-1-oxopropyl-l-lysylglycyl-l-ŕ-aspartyl-l-tryptophyl-l-propyl-l-cysteinamide, cyclic (1 - 60-disulfe). Kistrin (10-30 nmol/l) inhibited ADP- and collagen-induced aggregation stronger in P1a2(-) donors than in P1a2(+) donors; there was a significant difference between 50 p.c. inhibitory concentrations (IC50). The same tendency occurred with moderate concentrations of eptifibatide (40-100nmol/l) and also at low concnetrations of GR144053F (5-10 nmol/l) and high cncnetrations of echistatin (80-150 nmol/l), although in the case of the two latter inhibitors, the estimated IC50 values were not significantly different. In conclusion, GPIIb-IIIa blockers representing various clases are less...


    876/2523

    Tytuł oryginału: Inhibition and possible induction of rat CYP2D after short- and long-term treatment with antidepressants.
    Autorzy: Daniel Władysława A., Haduch A., Wójcikowski J.
    Źródło: J. Pharm. Pharmacol. 2002: 54 (11) s.1545-1552, il., tab., bibliogr. [45] poz.
    Sygnatura GBL: 300,961

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro
  • płeć męska

    Streszczenie angielskie: The aim of this study was to investigate the influence of tricyclic (imipramine, amitriptyline, clomipramine, despiramine), selective serotonin reuptake inhibitors (SSRIs: fluoxetine, sertraline) and novel antidepressant drugs (mitrazapine, nefazodone) on the activity of CYP2D, measured as a rate of ethylmorphine )-deethylation. the reaction was studied in control liver microsomes in the presence of the antidepressants, as well as in microsomes of rats treated intraperitoneally for one day or two weeks (twice a day) with pharmacological doses of the drugs (imipramine, amitriptyline, clomipramine, nefazodone 10 mg kg**-1 i.p.; desipramine, fluoxetine, sertaline 5 mg kg**-1 i.p.; mitrazapine 3 mg kg**-1 i.p.), in the absence of the antiderpressants in-vitro. Antidepressants decreased the activity of the rat CYP2D by competitive inhibition of the emzyme, the potency of their inhibitory effect being as follows: clomipramine(Ki = 14 ćm) sertraline ÷ fluoxetine (Ki = 17 and 16 ćm, respectively) imipramine ÷ amitripine (Ki = 26 and 25 ćm, respectively) desipramine (Ki = 44 ćm) nefazodone (Ki = 55 ćm) mirtazapine (Ki = 107 ćm). A oneday treatment with antidepressants caused a significant decrease in the CYP2D activity after imipramine, fluoxetine and sertraline. After prolonged administration of antidepressants, the decreased CYP2D activity produced by imipramine, fluoxetine and sertraline was still maintained. Moreover, amitriptyline and nefazodone significantly decreased, while mirtazapine increased the activity of the enzyme...


    877/2523

    Tytuł oryginału: The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors.
    Autorzy: Ossowska Krystyna, Konieczny Jolanta, Pilc Andrzej, Wolfarth Stanisław
    Źródło: Brain Res. 2002: 950 (1/2) s.88-94, il., bibliogr. 54 poz.
    Sygnatura GBL: 312,085

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of the present study was to find out whether the metabotropic receptor 1 (mGluR1) and group II mGluRs, localized in the striatum, are involved in antiparkinonian-like effects in rats. Haloperidol (1 mg/kg ip) induced parkinsonian-like muscle rigidity measured as an increased resistance of a rat's hind foot to passive flexion and extension at the ankle joint. (RS)-1-aminoindian-1,5-dicarboxylic acid (AIDA; 0.5-15 ćg/0.5 ćl), a potent and selective mGluR1 antagonist, or (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC; 7.5-15 ćg/0.5 ćl), a selective group II agonist, was injected bilaterally into the striatum of haloperidol-treated animals. AIDS in doses of 7.5-15 ć/g/0.5 ćl diminished the haloperidol-induced muscle rigidity. In contrast, 2R,4R-APDC injections were ineffective. The present results may suggest that the blockade of striatal mGluR1, but not the stimulation of group II mGluRs, may ameliorate parkinsonian muscle rigidity.


    878/2523

    Tytuł oryginału: Calcium-induced long-term potentiation in horizontal connections of rat motor cortex.
    Autorzy: Hess Grzegorz
    Źródło: Brain Res. 2002: 952 (1) s.142-145, il., bibliogr. 16 poz.
    Sygnatura GBL: 312,085

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: A transient (10 min) exposure of brain slices of young adult rats to elevated extracellular calcium (5 mM) resulted in a long-lasting potentiation of field potentials evoked in layer II/III and layer V horizontal connections of the primary motor cortex. This form of synaptic plasticity was blocked by D,L-2-amino-5-phosphonovalerate (APV, 100 ćM), an antagonist of NMDA receptors.


    879/2523

    Tytuł oryginału: A prospective comparison of antibiotic usage in pediatric surgical patients: the safety, advantage, and effectiveness of the surgical infection society guidelines versus a common practice.
    Autorzy: Górecki Wojciech, Grochowska Elżbieta, Krysta Mirosław, Wojciechowski Piotr, Taczanowska Anna, Stanek Beata
    Źródło: J. Pediatr. Surg. 2002: 37 (10) s.1430-1434, tab., bibliogr. 26 poz.
    Sygnatura GBL: 305,145

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • chirurgia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • in vitro

    Streszczenie angielskie: Background: The Surgical Infection Society (SIS) guidelines for antibiotic (Ab) usage minimally changed the surgical practice. The authors believed that clinical evidence of the safety, advantage, and effectiveness of SIS guidelines may improve inappropriate usage of Ab. Methods: A group of dedicated surgeons attempted to use Ab appropriately to SIS guidelines in their patients (group A). A comparison was made with a concurrent cohort of patients (group B), treated by surgeons who were nonsupporters of SIS guidelines. The trial was conducted in 378 children between. March 1999 and May 2000. The outcome measures were morbidity and mortality rates, Ab treatment duration, timing of administration, unjustified spectrum, and swith of Ab. Analysis of variance and Xý test were used in statistics. P value less than .05 was considered significant (s). results: Group A included 124 patients and Group B, 254. There were no intergroup differences in age, sex, and clen/contaminated/ratio of procedures. The mean duration of Ab treatment was 3.9 days in group A, versus 7.1 days in group B (s), with overall rate of appropriateness of 77 p.c. versus 36 p.c. (s) and no differences in mortality and morbidity rates. Conclusion: Perhaps these results may change Ab usage in pediatric surgery.


    880/2523

    Tytuł oryginału: Anthracyclines potentiate activity against murine leukemias L 1210 and P388 in vivo and in vitro.
    Autorzy: Szmigielska-Kapłon Anna, Ciesielska Ewa, Szmigiero Leszek, Robak Tadusz
    Źródło: Eur. J. Haematol. 2002: 68 (6) s.370-375, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 304,912

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Abstract: The interactions of 2-chlorodeoxyadenosine (2-CdA, cladribine) and three anthracyclines: doxorubicin (DOX), idarubicin (IDA) and mitoxantrone (MIT) were evaluated on murine leukemias P 388 adn L 1210. Prolongation of survival time of animals receiving drugs in combination compared to mice tereated with drugs in monotherapy was tested. We have also evaluated interactions of the cytostatics on murine leukemias in vitro by measuring their inhibitory effects on P 388 and L 1210 cell proliferation. We have observed a synergistic effect of MIT and IDA in combination with 2-CdA on P 388 leukemia resulting in an increase of life span (ILS) = 226 p.c in case of MIT + 2-CdA and ILS = 126 p.c. in the case of IDA + 2-CdA, whereas 2-CdA used as a sole drug resulted in an ILS = 47 p.c. The survival time of animals inoculated with P 388 leukemic cells and treated with DOX + 2-CdA was similar to ILS gained by DOX monotherapy (178 p.c. and 200 p.c. respectively). The mice bearing L 1210 leukemia receiving combined chamotherapy lived significantly longer than the animals on single agent regiments. The animals treated with schedule 2-CdA + MIT lived significantly longer (P = 0.004) as compard to the groups receiving drugs in monotherapy (ILS of 2-CdA + MIT group = 60 p.c., ILS of MIT groups 33 p.c., and 2-CdA group 33 p.c.). Finally, combination of DOX or IDA with 2-CdA resulted in ILS = 73 p.c. (2-CdA + DOX regimen), and ILS = 60 p.c. in case of 2-CdA + IDA regimen, which is significantly higher than ILS gained on monotherapy schedules. In vitro tests revealed that all tested anthracyclines enhance the antiproliferative activity of 2-CdA against L 1210 and P 388 leukemic cells (p 0.05)...


    881/2523

    Tytuł oryginału: Re-treatment with cladribine-based regimens in relapsed patients with B-cell chronic lymphocytic leukemia. Efficacy and toxicity in comparison with previous treatment.
    Autorzy: Robak Tadeusz, Boński Jerzy Z., Kasznicki Marek, Góra-Tybor Joanna, Hellmann Andrzej, Konopka Lech, Dmoszyńska Anna, Dwilewicz-Trojaczek Jadwiga, Wołowiec Dariusz
    Źródło: Eur. J. Haematol. 2002: 69 (1) s.27-36, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 304,912

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to determine the effectiveness and toxicity of cladribine (2-CdA) used alone or in combination with prednisone (P) or cyclophosphamide and mitoxantrone in te-treatment of patients with progressive B-cell chronic lymphocytic leukemia (B-CLL). We analyzed treatment outcome in 40 patients who had responded to previous treatment with 2-Cd-A-based regimens. Criteria for re-treatment were the same as for the first treatment. The patients were retreated with the same agents if they responded to the first treatment and then relapsed with progressive disease not earlier than 3 months after achieving the first response. Eight patients received 2-CdA alone (0.12 mg kg-1 d-1) i.v. for 5 d, and 21 patients additionally were given P (30 mg m-2 d-1) orally, also for 5 d. Eleven patients received 2-CdA for 3 d combined with cyclophosphamide (650 mg m-2) i.v. and mitoxantrone (10 mg m-2) i.v. on day 1 (CMC regimen). The cycles were repeated usually at 4 wk intervals or longer if severe myelosuppression or infections occurred. The therapy was finished if complete remission (CR) was achieved or until maximum of sic courses. Overall response (IR) in re-treatment was obtained in 16 out of 40 (40 p.c.) patients (95 p.c. CI 16-64), including 62 p.c. after 2-CdA, 33 p.c. after 2-CdA + P and 36 p.c. after CMC. CR was obtained in four (10 p.c.) patients. Residual disease evaluated in the patients with CR by surface immunophenotyping had been demonstrated in 5 out of 16 (31 p.c.) patients after the first treatment and in one out of four (25 p.c.) patients after re-treatment. The median...


    882/2523

    Tytuł oryginału: Aminoacyl-tRNA synthetases and aminoacylation of tRNA in the nuucleus.
    Autorzy: Mucha Piotr
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.1-10, il., bibliogr. 68 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: This review is focused on findings concerning the presence of translocation apparatus components (aminoacyl-tRNA synthetases, aminoacyl-tRNA, elongation factors) as well as translation itself in the nucleus. A nuclear role of these molecules is unknow. New findings suggest that well-accepted model of spatial segregation of transcription and translation in eukaryotic cell may be oversimplification. Nuclear coupling of both these processes show us how exciting and surprising may be the world of the living cell.


    883/2523

    Tytuł oryginału: GATA-1 binding to the ŕv promoter negatively regulates expression of the integrin ŕv subunit in human leukemic K562 cells.
    Autorzy: Czyż Małgorzata, Stasiak Marta, Boncela Joanna, Cierniewski Czesław S.
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.19-28, il., bibliogr. 30 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Recently we observed that the transcription factors Sp1 and Sp3 bind to the CTCCTCCTC sequence located between positions - 194 and - 172 of the ŕv promoter region and are directly involved in the regulation of transcriptional activity of teh ŕv gene in human umbilical vascular endothelial cells (HUVECs) (Czyz & Cierniewski, 1999, Eur. J. Biochem. 265, 638). In this report we provide evidence that the GATA-1 factor regulates ŕv expression during differentiation of pluripotent K562 cells induced either by phorbol 12-myristate 13-acetate (PMA) or butyric acid (BA) through interaction with the GATA element in the ŕv gene promoter. DNase I footprinting analysis revealed that region - 413 to - 408, covering the GATA binding site, was protected by nuclear extract from K562 cells. There was no protection of this region by HUVEC nuclear extract. Electrophoretic mobility shift assay (EMSA) analysis of nuclear extract of K562 cells treated with BA revealed an increase in GATA binding activity, which was associated with reduced ŕv mRNA and ŕv protein onn the cell surface. Stimulation of K562 cells with PMA resulted in opposite effects: lower expression of GATA-1 was associated wtih increased leveld of ŕv. We conclude that the GATA-1 transcription factor specifically binds to the GATA element in the ŕv gene promoter and negatively regulates ŕv gene expression.


    884/2523

    Tytuł oryginału: Selectivity of oxidative stress targeting in estorgen-induced experimental nephrocarcinogenesis.
    Autorzy: Kobiela Jarek, Krajewski Jacek, Kalińska-Błach Beata, Stefaniak Tomasz
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.51-58, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • nefrologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki

    Streszczenie angielskie: Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster neprhocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not afect lipids. Subcellular localization of the oxidative stress target wass determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected bay the oxidative stress.


    885/2523

    Tytuł oryginału: Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells.
    Autorzy: Gołębiewska Justyna, Rozwadowski Piotr, Spodnik Jan Henryk, Knap Narcyz, Wakabayashi Takashi, Woźniak Michał
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.59-65, il., bibliogr. 25 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We have demonstrated for the first time that the steroid metabolite, 2-methoxyestradiol (2-ME) is a powerful growth inhibitor of human osteosarcoma 143 B cell line by pleiotropic mechanisms involving cell cycle arrest at two different points and apoptosis. The ability of 2-ME to inhibit cell cycle at the respective points has been found concentration dependent. 1 ćM 2-ME inhibited cell cycle at G1 phase while 10 ćM 2-ME caused G2/M cell cycle arrest. As a natural estrogen metabolite 2-ME is expected to perturb the stability of microtubules (MT) in vivo analogously to Taxol - the MT binding anticancer agent. Contrary to 2-ME, Taxol induced accumulation of osteosarcoma cells in G2/M phase of cell cycle only. The presented data strongly suggest two different mechanisms of cytotoxic action of 2-ME at the level of a single cell.


    886/2523

    Tytuł oryginału: Comparative in vitro studies on liposomal formulations of amphotericin B and its derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME).
    Autorzy: Cybulska Barbara, Kupczyk Karolina, Szlinder-Richert Joanna, Borowski Edward
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.67-75, il., tab., bibliogr. 14 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: N-Methyl-N-D-fructosyl amphotericin B methyl ester (MFAME) is a semisynthetic derivative of the antifungal antibiotic amphotericin B (AMB). In contrast to the parent antibiotic, the derivative is charactiersed by low toxcity to mammalian cells and good solubility in water of its salts. Comparative studies on biological properties of free MFAME, AMB and their liposomal formulations were performed. To obtain liposomal forms, the antibiotics were inocporated into small unilamellar vesicles composed of dimyristoyl phosphatidylcholine (DMPC) and DMPC: cholesterol or ergosterol, 8:2 molar ratio. The effectivity of the liposomal and free forms of AMB and MFAME were compared by a determination of fungistatic and fungicidal activity against Candida albicans ATCC 10261, potassium release from erythrocytes, and haemolysis. The results obtained indicate that in contrast to AMB, incorporation of MFAME into liposomes did not further improve its selective toxicity. Studies on the antagonistic effect of ergosterol and cholesterol on the antifungal activity of the antibiotics indicated that sterol interference was definitely less pronounced in the case of MFAME than in the case of AMB.


    887/2523

    Tytuł oryginału: Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal acitivity.
    Autorzy: Janiak Agnieszka, Cybulska Barbara, Szlinder-Richert Joanna, Borowski Edward, Milewski Sławomir
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.77-86, il., tab., bibliogr. 23 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) and 2-amino-2-deoxy-D-glucitol-6-phosphate (ADGP) are strong inhibitors of the essential fungal enzyme, glucosamine-6-phospahte synthase, but their antifungal activity is poor, due to slow penetraton of these agents through the cytoplasmic membrane. In the present studies we have exploited the possibility of enhancement of ADGP and FMDP antifungal activity by improving their transport properties. It has been found that membrane-permeabilising polyene macrolides amphotericin B (AMB) and its N-methyl-N-fructosyl metyl ester derivative (MF-AME), at subinhibitory concentrations, facilitate diffusion of ADGP through the fungal cell membrane, thus allowing a decrease of its minimal inhibitory concentration (MIC). Synergistic effects have been observed for combinations of ADGP with AMB or MF-AME. Fractional inhibitory concentration (FIC) indexes, determined against a number of Candida spp., have been in the 0.18 - 0.81 range. Weak antifungal synergistic effects have been found for combinations of FMDP with AMB or MF-AME.


    888/2523

    Tytuł oryginału: The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.
    Autorzy: Bontemps-Gracz Maria M., Kupiec Agnieszka, Antonini Ippolito, Borowski Edward
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.87-92, il., tab., bibliogr. 9 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Two reacently syntehsized groups of acridine cytostatics containing fused heterocyclic ring(s): pyrazoloacridines (PAC) and pyrazolopyrimidoacridines (PPAC) were tested in regard to their in vitro cytotoxic activity towards a panel of sensitive and resistant human tumor cell lines. The obtained results corroborate our earlier hypothesis on the essential role of heterocyclic ring fused to the acridine moiety in the ability of acridine cytostatics to overcome multidrug resistance of tumor cells. The presence, location and kind of substituents considerably influenced both the cytotoxic acitivity of the derivatives and their ability to overcome multidrug resistance. The same factors also affected the cytostatics ability to differentiate between rumor cell lines with various types of drug exporting pumps.


    889/2523

    Tytuł oryginału: Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report.
    Autorzy: Styczyński Jan, Wysocki Mariusz, Dębski Robert, Balwierz Walentyna, Rokicka-Milewska Roma, Matysiak Michał, Balcerska Anna, Kowalczyk Jerzy, Wachowiak Jacek, Sońta-Jakimczyk Danuta, Chybicka Alicja
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.93-98, il., tab., bibliogr. 17 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • pediatria
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In vitro antileukemic activity of five glucocorticoids and their cross-resistance pattern in childhood acute lymphoblastic and non-lymphoblastic leukemia were determined by means of the MTT assay in 25 leukemia cell samples of childhood acute leukemias. The equivalent antileukemic concentrations of the drugs tested were: 34 ćM hydrocoritisone (HC), 8 ćM prednisolone (PRE), 1.5 ćM methylprednisolone (MPR), 0.44 ćM dexamethasone (DX) and 0.22 ćM betamethasone (BET). In comparison with initial ALL cell samples, the relapsed ALL group was more resistant to PRE (38-fold, p = 0.044), DX ( 34-fold, p = 0.04), MPR (38-fold), BET (45-fold) and HC (33-fold). The AML cell samples were even more resistant to: PRE ( 85-fold, p = 0.001), DX ( 34-fold, p = 0.004), MPR ( 69-fold, p = 0.038) and HC (54-fold, p = 0.059) when compared with ALL on initial diagnosis. A sigificant cross-resistance among all the glucocorticoids used was found. Only in some individual cases the cross-resistance was less pronounced.


    890/2523

    Tytuł oryginału: The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia.
    Autorzy: Styczyński Jan, Wysocki Mariusz, Dębski Robert, Kurylak Andrzej, Balwierz Walentyna, Rokicka-Milewska Roma, Matysiak Michał, Balcerska Anna, Kowalczyk Jerzy, Wachowiak Jacek, Sońta-Jakimczyk Danuta, Chybicka Alicja
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.99-107, il., tab., bibliogr. 14 poz. - 8 Międzynarodowe Sympzjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • pediatria
  • toksykologia
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Uptake and efflux of two anthracyclines, idarubicin (IDA) and daunorubicin (DNR), was studied in childhood acute leukemia samples. A comparison of IDA and DNR transport phenomena in relation to drug cytotoxicity and expression of P-glycoprotein (PGP) was made. Intracellular content of IDA/DNR was determiend by flow cytomery using the fluorescent properties of the drugs. In vitro drug cytotoxicity was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. PGP expression was analysed by flow cytometry. The uptake and efflux rates were non-significantly higher for IDA than DNR. There were no differences between three types of leukemia with respect to drug content during accumulationand retention. After correction for the cell volume, intracellular concentration of both drugs in each moment of uptake and efflux was significantly lower in relapsed ALL and AML samples in comparison with initial ALL cells. Efflux, but not uptake, of both drugs was inversely correlated with PGP expression ad IDA, but not DNR, cytotoxicity. The cytotoxicity was correlated with drug accumulation for both drugs and with drug retention for IDA. In conclusion, it seems that (1) intracellular content was related to the lippopholic properties of the drugs rather than to the type of leukemia, (2) decreased intracellular concentration of both drugs might have an impact on compromised therapy results in AML and relapsed ALL children, (3) IDA presents higher cytotoxicity, which possibly might be decreased by the presence of PGP. These results might have a practical impact on the rational design of new chemotherapy protocols.


    891/2523

    Tytuł oryginału: Influence of G2 arrest on the cytotoxicity of DNA topoismerase inhibitors toward human carcinoma cells with different p53 status.
    Autorzy: Bożko Przemysław, Larsen Annette K., Raymond Eric, Składanowski Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.109-119, il., bibliogr. 29 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • genetyka
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: We here report the influence of the cell cycle abrogator UCN-01 on RKO human colon carcinoma cells differing in p53 status following exposure to two DNA damaging agents, the topoisomerase inhibitors etoposide and camptothecin. Cells were treated with the two drugs at the IC90 concentration for 24 h followed by post-incubation in drug-free medium. RKO cells expressing wild-type, functional p53 arrested the cell cycle progression in both the G1 an G2 phases of the cell cycle whereas teh RKO/E6cells, which lack functional p53, only arrested in the G2 phase. Growth-arrested cells did not resuem proliferetion even after prolonged incubation in drug-free medium (up to 96 h). To evaluate the importance of the cell cycle arrest on cellular survival, a non-toxic dose of UCN-01 (100 nM) was added to the growth-arrested cells. The addition of UCN-01 was accompanied by mitotic entry as revealed by the appearance of condensed chromatin and the MPM-2 phosphoepitope, which is charactieristic for mitotic cells, G2 exit and mitotic transit was accompanied by a rapid activation of caspase-4 and apoptotic cell death. The influence of UCN-01 on the long-term cytotoxic effects of the two drugs was also determined. Unexpectedly, abrogation of the G2 arrest had no influence on the overall cytotoxicity of either drug. In contrast, addition of UCN-01 to cisplatin-treated RKO and RKO/E6 cells greatly increased the cytotoxic effects of the alkylating agent. These results strongly suggest that even prolonged cell cycle arrest in the G2 phase of the cell cycle is not necessarily coupled to efficient DNA repair and enhanced cellular survival as generally believed.


    892/2523

    Tytuł oryginału: TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine.
    Autorzy: Gloc Ewa, Warszawski Mariusz, Młynarski Wojciech, Stolarska Małgorzata, Hoser Grażyna, Skorski Tomasz, Błasiak Janusz
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.121-128, il., bibliogr. 30 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The TEL/JAK2 chromosomal translocation (t(9;12)(p24;p13) is associated with T cell childhood acute lymphoblastic leukemia. The TEL/JAK2 fusion protein contains the JAK2 catalytic domain and the TEL-specific oligomerization domain. TEL-mediated oligomerization of the TEL/JAK2 proteins results in the constitutive activation of the tyrosine kinase activity. Leukemia cells expressing TEL/JAK2 tyrosine kinase become resistant to anti-neoplastic drugs. Amifostine is a pro-drug which can selectively protect normal tissues against the toxicity of anticancer drugs and radiation. We investigated the effects of amifostine on idarubicin-induced DNA damage and repair in murine pro-B lymphoid BaF3 cells and BaF3-TEL/JAK2-transformed cells using alkaline single cell gel electrophoresis (comet assay). Idarubicin induced DNA damage in both cell types but amifostine reduced its extent in control non-transformed BaF3 cells and enhanced it in TEL/JAK2-transformed cells. The transformed cells did not show measurable DNA repair after exposure to amifostine and idarubicin, but cells treated only with idarubicin were able to recover within a 60-min incubation. Because TEL/JAK2-transformed cells can be considered as model cells for certain human leukemias and lymphomas we anticipate an enhancement of idarubicin cytotoxicity by amifostine in these diseases. Moreover, TEL/JAK2 tyrosine kinase might be involved in cellular response to DNA damage. Amifostine could promote apoptosis or lower the threshold for apoptosis induction dependent on TEL/JAK2 activation.


    893/2523

    Tytuł oryginału: 5' - Esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with cell differentiation-provoking agents.
    Autorzy: Grieb Paweł, Kryczka Tomasz, Wójtowicz Radosław, Kawiak Jerzy, Kazimierczuk Zygmunt
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.129-137, il., bibliogr. 20 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Phenylacetic and retinoic acids are carboxyacidic cell differentiating agents displaying anticancer activities. We report on a new class of compounds including the 5'-esters of 2'-deoxyadenosine (dA) or 2-chloro-2'-deoxyadenosine (cladribine, 2CdA) and the aforementioned acids. The rationale behind the synthesis of these esters was that if they are hydrolyzed inside the lymphoid cells, either dA will be removed from the intracellular environment by deamination, or 2CdA will be phosphorylated and accumulated. In either case targetted delivery of the differentiating agent to the lymphoid cells may be envisaged. The said compounds were synthesized by the Mitsunobu procedure employing triphenylphosphine and azadircarboxylic acid esters, and their stability was tested against various esterases. Esters of dA and 2CdA with phenylacetic acids were found to be resistant to enzymatic hydrolysis, whereas those with retinoic acids were efficiently hydrolyzed by commercially available hepatic esterase as well as by esterases present in the blood plasma and in diluted human lymphocyte lysate. Susceptibility to enzymatic hydrolysis was found to be a prerequisite of cytotoxic and/or differentiating activity of these esters in leukemic cell lines.


    894/2523

    Tytuł oryginału: Cytotoxic effect of nitric oxide on human hematological malignant cells.
    Autorzy: Tsumori Michihiro, Tanaka Junko, Koshimura Kunio, Kawaguchi Mikiko, Murakami Yoshio, Kato Yuzuru
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.139-144, il., tab., bibliogr. 10 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.


    895/2523

    Tytuł oryginału: A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone.
    Autorzy: Błasiak Janusz, Gloc Ewa, Warszawski Mariusz
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.145-155, il., bibliogr. 38 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Idarubicin is an anthracycline antibiotic used in cancer therapy. Mitoxantrone is an anthracycline analog with presumed better antineoplastic activity and lesser toxicity. Using the alkaline comet assay we showed that the drugs at 0.01 - 10 ćM induced DNA damage in normal human lymphocytes. The effect induced by idarubicin was more pronounced than by mitoxantrone (P 0.001). The cells treated with mitoxantrone at 1 ćM were able to repair damage to their DNA within a 30-min incubation, whereas the lymphocytes exposed to idarubicin needed 180 min. Since anthracyclines are known to produce free redicals, we checked whether reactive oxygen species might be involved in the observed DNA damage. Catalase, an enzyme inactivating hydrogen peroxide, decreased the extnt of DNA damage induced by idarubicin, but did not affect the extent evoked by mitoxantrone. Lymphocytes exposed to the drugs and treated with endonuclease III or formamidopyrimidine-DNA glycosylase (Fpg), enzymes recognizing and nicking oxidized bases, displayed a higher level of DNA damage than the untreated ones. 3-Methyladenine-DNA glycosylase II (AlkA), an enzyme recognizing and nicking mainly methylated bases in DNA, increased the extent of DNA damage caused by idarubicin, but not that induced by mitoxantrone. Our results indicate that the induction of secondary malignancies should be taken into account as side effects of the two drugs. Direct strand breaks, oxidation and methylation of the DNA bases can underlie the DNA-damaging effect of idarubicin, whereas mitoxantrone can induces strand breaks and modification of the bases, including oxidation. The observed in normal lymphocytes much lesser genotoxicity of mitoxantrone compared to idarubicin should be taken into account in planning chemotherapeutic strategies.


    896/2523

    Tytuł oryginału: The analysis of structure - anticancer and antiviral activity relationships for macrocyclic pyridinophanes and their analogues on the basis of 4D QSAR models (simplex representation of molecular structure).
    Autorzy: Kuz'min Victor E., Artemenko Anatoly G., Lozitsky Victor P., Muratov Eugene N., Fedtchouk Alla S., Dyachenko Natalia S., Nosach Lidiya N., Gridina Tatiyana L., Shitikova Larisa I., Mudrik Liubov M., Mescheriakov Aleksey K., Chelombitko Vladislav A., Zheltvay Andrey I., Eynde Jean-Jaques Vanden
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.157-168, il., tab., bibliogr. 19 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: A new 4D-QSAR approach has been considered. For all investigated moleucles the 3D structural models have been created and the set of conformers (fourth dimension) have been used. Each conformer is represented as a system of different simplexes (tetratomic fragments of fixed structure, chirality and symmetry). The investigation of influence of molecular structure of macrocyclic pyridinophanes, their analgues and certain other compounds on anticancer and antiviral (anti-influenza, antiherpes and antiadenovirus) activity has been carried out by means of the 4D-QSAR. Statistic charactierstics from QSAR of PLS (partial least squares) models are satisfactory (R = 0.94 - 0.97; CVR = 0.63 - 0.83).


    897/2523

    Tytuł oryginału: Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy (GDEPT).
    Autorzy: Misiura Konrad, Szymanowicz Daria, Kuśnierczyk Halina, Wietrzyk Joanna, Opolski Adam
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.169-176, il., tab., bibliogr. 18 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • farmacja
  • gastroenterologia
  • onkologia
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • Świnie
  • in vitro

    Streszczenie angielskie: Two types of prodrugs, benzyl analogues of isophosphoramide mustard (iPAM), activated by cytochrome P450, and acylthioethyl analogues, activated by esterases, were designed. In contrast to iPAM that hydrolyse rapidly, the examined compounds are stable in phosphate-vuffered saline and Tris buffer. Benzyl analgoues of iPAM are poor substrates for cytochrome P450, are not cytotoxic and posses no antitumour activity. Acylthiethyl analogues of iPAM are good substrates for pig liver esterase, are cytotoxic and exertanti tumour activity against L1210 leukaemia in mice. The observed correlation for iPAM analogues between their susceptibility to hydrolysis and cytotoxicity and antitumour activity suggests possible application of these compounds as the prodrugs in gene-directed enzyme-prodrug therapy.


    898/2523

    Tytuł oryginału: New carbocyclic analogues of netropsin: Synthesis and inhibition of topoisomerases.
    Autorzy: Pućkowska Anna, Bielawski Krzysztof, Bielawska Anna, Różański Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.177-183, il., bibliogr. 25 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: A series of carbocyclic analgues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted banzene rings and unsubstituted N-terminal NH2 groups. Compounds 4 - 7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamthylene) chains. In the topoisomearse I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4 - 7 at 100 ćM concentration.


    899/2523

    Tytuł oryginału: Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.
    Autorzy: Kazimierczuk Zygmunt, Upcroft Jacqueline A., Upcroft Peter, Górska Agata, Starościak Bohdan, Laudy Agnieszka
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.185-195, il., tab., bibliogr. 20 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Two series of benzimidazole derivatives were synthesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-substituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtainned compounds was studied. Some thioalkyl derivatives showed remarkable activity against nosocomial strains of Stenotrophomonas malthophilia, and an activity comparable to that of metronidazole agains Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole sowed the most distinct antiprotozoal activity.


    900/2523

    Tytuł oryginału: In vitro releas of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers.
    Autorzy: Kryczka Tomasz, Bero Maciej, Kasperczyk Janusz, Dobrzyński Piotr, Marciniec Barbara, Popielarz-Brzezińska Maria, Grieb Paweł
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.205-210, il., tab., bibliogr. 19 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: The aims of our study were to assess the release of cytotoxic nucleoside analgs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were strilized either with ethylene oxide at 37řC, or with gamma radiation (15 kGy, 20 kGy, or 25 kBy). The kinetics of nucleoside release form the copolymers were measured over 50 days. Four copolymers exhibited realtively constant release of nucleosides in micromolar concentrations during the entire oberslightly influence nucleosides in micromolar concentrations during the entire observation period. Sterilization with either ethylene oxide or gamma radiation only slightly influence nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indicated.


    901/2523

    Tytuł oryginału: Changes in the cellular behaviour of human colonic cell line Caco-2 in response to butyrate treatment.
    Autorzy: Dzierżewicz Zofia, Orchel Arkadiusz, Węglarz Ludmiła, Latocha Małgorzata, Wilczok Tadeusz
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.211-220, il., bibliogr. 23 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Gut-derived adenocarcinoa Caco-2 cells were treated with sodium butyrate (NaB) at physiologically relevant concentrations. We characterized its effects on proliferation, differentiation, apoptosis, adhesion to the solid support and interleukin-8 secretion. Differentiation was determined by brush border alkaline phosphoatase activity. Apoptosis was assessed by acridine orane and Hoechst stains. Differentiation and apoptosis were analyzed in both adherent and floating cell populations. The transformed Caco-2 cells did not retain their malignant phenotype in the presence of NaB. They appeared to undergo a change in the phenotype induced by NaB, as indicated by reduced proliferation, enhanced differentiation, stimulation of apoptosis leading to decreased viablility of cells, and stimulaiton of interleukin-8-secretion. Considering all the above facts and data, we postulate that Caco-2 cells cultured in NaB supplemented medium could regain the phenotypic characteirstics of the phenotype of the parent cell from which originated the caco-2 line.


    902/2523

    Tytuł oryginału: In vitro activity of oxazaphosphorines in childhood acute leukemia: Preliminary report.
    Autorzy: Styczyński Jan, Wysocki Mariusz, Dębski Robert, Balwierz Walentyna, Rokicka-Milewska Roma, Matysiak Michał, Balcerska Anna, Kowalczyk Jerzy, Wachowiak Jacek, Sońta-Jakimczyk Danuta, Chybicka Alicja
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.221-225, il., tab., bibliogr. 9 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • pediatria
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: Glufosfamide (á-D-glucosyl-ifosfamide mustard) is a new agent for cancer chemotherapy. Its pharmacology is similar to commonly used oxazaphosphorines, but it does not require activation by hepatic cytochrome P-450 and preclinically demonstrates lower nephrotocity and myelosuppression than ifosfamide. The aim of the study was a comparison of the drug resistance profiles of gufosfamide and other exazaphosphorines in childhood acute leukemias. Leukemic cells, taken from children with ALL on diagnosis (n = 41), ALL on relapse (n = 12) and AML on diagnosis (n = 13) were analyzed by meand of the MTT assay. The following drugs were tested: glufosfamide (GLU), 4-HOO-ifosfamide (IFO), 4-HOO-cyclophosphamide (CYC) and malfosfamide cyclohexylamine salt (MAF). In the gorup of initial ALL samples median cytotoxicity values for GLU, IFO, CYC and MAF were 15.5, 33.8, 15.7 and 7.8 ćM, respectively. In comparison with initial ALL samples, the relative resistance for GLU and IFO in relapsed ALL samples was 1.9 (p = 0.049) and 1.3 (ns), and in initial AML samples 31 (p 0.001) and 5 (p = 0.001), respectively. All oxazaphosphorines presented highly significant cross-resistance. Glufosfamide presented high activity against lymphoblasts both on diagnosis and on relapse.


    903/2523

    Tytuł oryginału: Monitoring of urine nitric oxide (NO) related substrates and immunological competence in hematological malignancy.
    Autorzy: Tanaka Junko, Koshimura Kunio, Tsumori Michihiro, Murakami Yoshio, Kato Yuzuru
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.227-232, il., tab., bibliogr. 10 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • immunologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: It has been reported that concentrations of neopterin in the urine are changed according to the host immunological conditions. In the present study, we measured urinary concentration of neopterin in patients with malignant hematological disorders and investigated the relationship between urinary neopterin levels and laboratory indices for cellular immunity. Urine neopterin levels were correlated with serum sIL-2R levels in the patients with malignant lymphoma, and inversely correlated with lymphocyte reactivity with ConA in the patients with acute myeolocytic leukemia. However, no significant correlation was observed between uring neopterin levels and lymphocyte reactivity with phytohemagglutinin and pokeweed mitogen, CD4/8 ratio, CD56+16+ subset or serum IFN-ç levels. In the patients with malignant lymphoma, parallel changes in serum sIL-2R and uring neopterin were observed. The presented results suggest that urine neopterin levels are related to the activation of T cells in malignant lymphoma.


    904/2523

    Tytuł oryginału: Effect of cyclosporin A on immunological response in lungs of guinea pigs infected with Trichinella spiralis.
    Autorzy: Dzik Jolanta M., Zieliński Zbigniew, Gołos Barbara, Jagielska Elżbieta, Wranicz Mariusz, Wałajtys-Rode Elżbieta
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.233-247, il., tab., bibliogr. s. 243-247 - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie

    Streszczenie angielskie: The efects of cyclospirin A (CsA), a potent immunosuppressive drug with antiparasitic activity, on the innate immunological response in guinea pig lungs during an early period (6th adn 14th days) after T. spiralis infection were studied. CsA treatment of T. spiralis-infected guinea pigs caused a significant attenuation of immunological response in lungs by decreasing lymphocyte infiltration into pulmonary alveolar space, inhibiting alveolar macrophage superoxide anion production and lowering both the production of NO metabolites measured in bronchoalveolar lavage fluid and expression of the iNOS protein in lung homogenates, allowing us to speculate that the T. spiralis-dependent immunological reponse is dependent on lymphocyte T function. Interestingly, CsA itself had a pro-inflammatory effect, promoting leucotyte accumulation and macrophage superoxide production in guinea pig lungs. This observation may have a relevance to the situation in patients undergoing CsA therapy. Macrophage expression of the iNOS protein, evaluated by immunoblotting was not influenced by treatment of animals with CsA or anti-TGF-antibody, indicating different of the guinea pig and murine enzymes.


    905/2523

    Tytuł oryginału: In vivo effect of diallyl sulfide and cimetidine on phenacetin metabolism and biovailability in rat.
    Autorzy: Szutowski Mirosław M., Zalewska Katarzyna, Jadczak Marta, Marek Monika
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.249-256, il., bibliogr. 29 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Numerous cytochrome P450 inhibitors have been described as effective modulators of cytochrome P450 isoforms activity in vitro. Their inhibitory efficiency may be considerably modified after in vivo application. The aim of this study was to ecamine the effect of oral administration of diallyl sulfide - a cytochrome P450 2E1 inhibitor and cimetidien - a cytochrome P450 2C6 and 2C11 inhibitor on rat serum concentration of phenacetin and its metabolite acetaminophen. Both inhibitors increased area under the curve (AUC0-4h) for phenacetin by 50 p.c. Only cimetidine reduced AUC0-4h for acetaminophen indicating inhibition of O-deethylation activity. Quinidiene - a cytochrome P450 2D subfamily and P-glycoprotein inhibitor did not change significantly phenacetin biovailability. These results suggest that diallyl sufide inhibits the deacetylation pathway catalysed by arylamine N-acetyl transferase. Beside cytochroe P450 1A2 other cytochrome P450 isoforms (2A6 adn /or 2C11) are involved in phenacetin O-deethylation in rat.


    906/2523

    Tytuł oryginału: Heteroplasmy analysis in the Polish patients with 11778A mutation responsible for Leber hereditary optic neuropathy.
    Autorzy: Mroczek-Tońska Katarzyna, Ratajska Dorota, Guillot Cecile, Sąsiadek Maria, Ambroziak Anna, Lubos Leszek, Bartnik Ewa
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.257-262, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • neurologia
  • okulistyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We have analysed the heteroplasmy level in 11 individuals from 3 families harbouring the mitochondrial 11778A mutation responsible for Leber hereditary optic neuropathy using last cycle hot PCR. The mutation level exceeded 90 p.c. both in affected and in unaffected individuals. We also checked whether any of the families belonged to the J haplogroup of mitochondrial DNA and obtained a negative results.


    907/2523

    Tytuł oryginału: Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension.
    Autorzy: Derebecka Natalia, Hołysz Marcin, Dankowski Rafał, Wierzchowiecki Michał, Trzeciak Wiesław H.
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.263-268, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Nitric oxide (NO) is synthesised in the vascular endothelium by nitric oxide synthase (NOS3) and is an important factor in the regulation of blood pressure. Imapired synthesis of NO due to mutations in the NOS3 gene is associated with hypertension. To date several allelic variants of the NOS3 gene have been identified and their possible linkage with hypertension investigated. We studied the distribution of genotypes and frequency of alleles of the G11T polymorphism in intron 23 of the NOS3 gene in patients with hypertension and in a control groups of healthy individuals. The polymorphism was determined by PCR-RFLP analysis. The distribution of genotypes in the patients with hypertension and in the healthy individuals did not differ significantly from the values predicted from Hardy-Weinberg equilibrium for the general population. No major differences in the distribution of the G11T polymorphsm in the patients and healthy individuals were found (P 0.05).


    908/2523

    Tytuł oryginału: Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.
    Autorzy: Gackowski Daniel, Kruszewski Marcin, Banaszkiewicz Zbigniew, Jawień Arkadiusz, Oliński Ryszard
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.269-272, tab., bibliogr. 14 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.


    909/2523

    Tytuł oryginału: Adhesive properties of cacinoembryonic antigen glycoforms expressed in glycosylation-deficient Chinese hamster ovary cell lines.
    Autorzy: Krop-Watorek Anna, Kłopocki Arkadiusz G., Czerwiński Marcin, Lisowska Elwira
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.273-283, il., bibliogr. s. 280-283
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: Carcinoembryonic antigen (CEA) is an oncofoetal cell surface glycoprotein that serves as an important tumour marker for colorectal and some other carcinomas. Its immunoglobulin-like structure places CEA within the immunoglobulin superfamily. CEA functions in several biological roles including homotypic and heterotypic (with other CEA familiy members) cell adhesion. Cell-cell interaction can be modulated by different factors, e.g., post-transplational modifications such as glycosylation. The purpose of this study was to examine whether changes in carbohydrate composition of CEA oligosaccharides can influence homotypic (CEA-CEA) interactions. In order to modulate glycosylation of CEA we used two different glycosylation mutants of Chinese hamster ovary (CH)) cells, Lec2 and Lec8. Lec2 cells showuld produce CEA with nonsialylated N-glycans, while Lec8 cells should yield more truncated sugar structures than Lec2. Parental CHO (Pro5) cells and the glycosylation deficient mutants were stably transfected wtih CEA cDNA. All three CEA glycoforms, tested in a solid-phase cell adhesion assay, showed an ability to mediate CEA-dependent cell adhesion, and no qualitative differences in the adhesion between the glycoforms were observed. Thus, it may be assumed that carbohydrates do not plas a role in homotypic adhesion, and the interactions between CEA molecules depend solely on the polypeptide structure.


    910/2523

    Tytuł oryginału: Various cationic carriers for in vitro transfection of tumor and endothelial cell lines.
    Autorzy: Zemlińska Barbara, Sochanik Aleksander, Missol-Kolka Ewa, Szala Stanisław
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.285-290, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: We compared the efficiency of in vitro DNA transfer into selected tumor and endothelial cell lines using complexes of plasmid DNA and cationic carriers: DDAB/DOPE, DC-Chol/DOPE, Art-Chol/DOPE, Gly-Chol/DOPE, Arg-Gly-Chol/DOPE, BGTC/DOPE, and PEI. The best carriers for transfecting the majority of tested cells lines at optimized carrier-to-DNA weight ratios were PEI and BGTC/DOPE.


    911/2523

    Tytuł oryginału: Oligodeoxyadenylate stimulates the protein kinase activity of anti-DNA sIgA from human milk.
    Autorzy: Kit Yuri, Kuligina Elena, Semenov Dimitry, Richter Vladimir
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.291-294, il., biblogr. 15 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: Preparations of anti-DNA sIgA were obtained from human milk by sequential chromatography on protein A-sepharose, DEAE-fractogel and DNA-celluloses. The influence of oligonucleotides on protein kinase activity was investigated. It was discovered that incubation of anti-DNA sIgA with oligodeoxyriboadenylate d(A)12 stimulates the phosphorylation of polypeptides of sIgA in the presence of [ç-32P]ATP. The greatest was the incorporation of 32P into the sIgA H-chains. We also demonstratrated stimulation of the casein kinnase activity of anti-DNA sIgA by d(A)12. The stimulation of the protein kinase activity of anti-DNA sIgA by oligoriboadenylate r(A)12 was not detected.


    912/2523

    Tytuł oryginału: Gynecologic complications and management of HIV disease.
    Autorzy: Nassiri R., Sikorski R[adzisław] J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (4) s.175-185, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • aIDS
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Over 34.7 million people worldwide are estimated to be infected with HIV. In developing countries, new antiretroviral drug combiantions (HAART therapy) have reduced the incidence of AIDS and therefore, increased the life expectancy of those with the HIV disease. However, the number of women infected with HIV is increasing worldwide particularly, in lower socioeconomics in the third-world vountreis as weel as lower socioeconomics and minorities in the USA. The management of pregnancy in HIV-positive women should be seen as part of the comprehensive and longterm care of the woman provided to her. Obstetric management will be similar to that for uninfected women in most instances, although invasive diagnostic procedures should be avoided, and iron folate and other vitamin supplementation should be considered. In areas of high prevalence, these procedures should be for all pregnant women. HIV testing in pregnancy has a number of benefits in terms of prevention and care for mother and child but this must be balanced against possible risks of stigmatization, discrimination and violence. In order to avoid or minimize negative consequences, testing must be voluntary and confidential followed by quality counseling. Although the number of women infected with HIV is significatly lower in Poland than in other central and eastern European countries, the UNAIDS surveillance data suggest that the HIV cases may increase among women in Poland for the next decade. In this review, we delineate facts in gynecologic aspects of HIV infection and provide an up-to-date overview of clinical management of HIV infection in women.


    913/2523

    Tytuł oryginału: Genetic analysis of matrix metalloproteinase 3 (MMP-3) 5A/6A promoter polymorphism in women with ovarian cancer.
    Autorzy: Szyłło K., Romanowicz-Makowska H., Niewiadomski M., Kozłowska E., Kulig A., Smolarz B[eata]
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (4) s.193-197, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Objective: Matrix metalloproteinase 3 (MMP-3) overexpression is observed in cancer tissue. In the present work the relationship between genotypes of 5A/6A polymorphism in the promoter region of MMP-3 gene and the appearance of ovarian cancer was investigated. Patient and methods: Blood and tumour tissue were obtained from 20 women with ovarian cancer. Blood samples form age matched healthy women served as control. The genotypes of 5A/6A polymorphism were determined by PCR amplification using the allele specific primers. Results: There were significant differences in distributions of genotypes of 5A/6A polymorphism between patients and controls (p 0.05). No differences between genotypes of the 5A/6A polymorphism in blood and cancer tissue of each patient wre found. Conclusion: The results obtained indicated that the 5A/6A polymorphism of MMP-3 gene may be linked with appearance of ovarian cancer.


    914/2523

    Tytuł oryginału: Intracytoplasmic sperm injection in patients with idiopathic retrograde ejaculation.
    Autorzy: Radwan M[ichał], Banaszczyk R., Pawlicki J., Kozarzewski M., Radwan J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (4) s.199-203, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • urologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Aim: The aim of the study was to estimate the effectiveness of the ICSI therapy of idiopathic retrograde ejeculation (RE) - induced infertility. Material and methods: In three couples in which the men suffered from idiopathic RE with 4.9 and 12 years of infertility, three ICSI cycles were performed with spermatozoa retrieved from the post ejaculatory urine. Results: The fertilization rate averaged higher than 60 p.c. Two clinical pregnancies were achieved. Conclusion: In case of idiopathic RE infertility, the causes cannot be established, ad thus it is difficult to find an effective therapy, the only reasonable solution for men with low sperm semen quality is to employ the ICSI procedure.


    915/2523

    Tytuł oryginału: Expression of nm23H1, proliferative activity and the presence of papillomavirus in squamous epithelial carcinoma of uterine cervix.
    Autorzy: Kędzia W[itold], Schmidt M., Olejnik A., Goździcka-Józefiak A., Spaczyński M.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (4) s.205-211, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Purpose: the purpose of the paper was to analyse nm23H1 protein expression in squamous epithelial carcinoma of uterine cervix in relation to the stage and grade of carcinomas, clinical progression, proliferative activity and presence of HPV 16 and 18 viruses. Patients and methods: the expression of nm23H1 was analysed in 38 cases of squamous epithelial carcinma by means of the immunohistochemical method. For virological studies DNA was isolated from carcinomatous tissue and the presence of HPV 16 and 18 viruses determined by the PCR method. Results: no correlation was found between the accumulation of nm23H1 protein and the degree of clinical progression, histological maturity and presence of HPV 16 and 18 viruses. However, a statistically significant correlation was found between the group of not differentiated and well differentated carcinomas (p 0.0213). It was noted that all carcinomas characterised by overexpression of nm23H1 protein were HPV 16, 18 positive. Conclusions: overexpression of nm23H1 protein presence of HPV 16, 18 might indicate clinically more malignant form of squamous epithelial carcinoma of uterine cervix.


    916/2523

    Tytuł oryginału: N-acetyltransferase (NAT2) gene polymorphism in women with ovarian carcinoma.
    Autorzy: Skorupska E[lżbieta], Friebe Z., Korzeniowska K.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (4) s.213-217, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Purpose: The aim of the study was a molecular analysis of N-acetyltransferase (NAT2) gene in the aspect of a risk group of ovarian carcinoma morbidity. Patients and methods: Fifty women with ovarian carcinoma (the study group) and fifty healthy women (the control group) were analysed. Analysis of a N-acetyltransferase gene was undertaken by PCR (polymerase chain reaction) - RFLP (restriction fragment length polymorphism). Results: This study shows that there is a statistically significant difference in the NAT2 alleles frequency distribution in the groups of ovarian carcinoma and healthy women. There is no statistically significant difference in the frequency distribution of NAT2 genotypes in those groups. Conclusions: Women with double mutant NAT2 alleles are genetically predisposed to the development of ovarian carcinoma. There is no association between particular NAT2 genotypes and morbidity of ovarian carcinoma.


    917/2523

    Tytuł oryginału: Pregnancy in a patient with hereditary angio-oedema (HANE) syndrome. A case report.
    Autorzy: Smolarczyk R[oman], Grymowicz M., Czajkowski K., Broś M., Wójcicka-Bentyn J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 4 (4) s.219-222, bibliogr. 9 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • farmacja
  • genetyka
  • ginekologia i położnictwo
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Uncomplicated delivery in a 24-year-old woman with hereditary angio-oedema is presented in the study. Literature revieew about prognosis, treatment and prophylxis of HANE syndrome during pregnancy and labour has been included.


    918/2523

    Tytuł oryginału: Histone mRNA in situ hybridization in assessing proliferative activity of normal and malignant cells.
    Autorzy: Słowiński Jerzy, Mazurek Urszula, Bierzyńska-Macyszyn Grażyna
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.335-339, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Proliferative capacity is an important determinant of tumour biological behaviour. For research and diagnostic purposes, immunohistochemical techniques are usually in the assessment of tissue proliferative status. An interesting alternative for these studies is a detection of histone mRNA. As the synthesis of histones is tightly coupled with DNA replication during S-phase of the cell cycle, histone mRNA level is a specific marker of S-phase cells. Furthermore, a short-lived transcript guarantees accurate estimation of S-phase cell pool at the moment of tissue fixation. The progress in molecular biology techniques during the last decade made possible the use of in situ hybridization, especially its non-radioactive version, in routine laboratory services. This technique can be successfully applied to detection of histone mRNA in routinely processed tissues. Advantages and limitations of such approach in tumour proliferation studies are discussed.


    919/2523

    Tytuł oryginału: IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells.
    Autorzy: Cisowski Jarosław, Zarębski Adrian, Koj Aleksander
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.341-345, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: It is known that during acute phase reaction IL-6 activates STAT3 in hepatoma cells and IL-1 downregulates this response. We found that the inhibitory properties of IL-1 on STAT signaling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antixidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4. It appears that cytokien crosstalk between IL-6 and IL-1 includes a direct pathway sensitive to antioxidants and MAP kinase inhibitors, whereas the indirect prolonged response depends probably on synthsis of suppressors of cytokine signalling (SOCS).


    920/2523

    Tytuł oryginału: Expression of TCR-dżeta chain and apoptosis in subpopulations of tumor-associated lymphocytes (TALs) from malignant pleural effusions.
    Autorzy: Sikora Jan, Żeromski Jan
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.347-351, il., bibliogr. 18 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Malignant effusions in serous carvities represent suspension of tumors and inflammatory cells and therefore present an attractive model for studying tumor-host interactions. T cell functional ability is linked to proper signal transduction via T cell receptor (TCR-CD3 complex), espceially its dżeta chain. The latter has been found to be often depressed in malignancy. Aim of this study was to assess alterations of dżeta chain expression and its relation to apoptosis of T lymphocytes. T lymphocytes obtained from pleural effusions of 20 cancer patients and 9 patients with nonmalignant effusions serving as a control were studied. The analysis was performed using flow cytometry combining CD3, CD4, CD8, CD16/56, TCR-dżeta and TUNEL reaction. In the control group, T lymphocytes obtained from pure lymphocyte effusions had constantly high level of dżeta chain while those from malignant pleural effusions had a decreased dżeta chain expression. Lymphocytes with low dżeta chain expression were the main subpopulation of T cells undergoing apoptosis.


    921/2523

    Tytuł oryginału: The compounds from the hollyhock extract (Althaea rosea Cav. var. nigra) affect the aromatization in rat testicular cells in vivo and in vitro.
    Autorzy: Papież Monika, Gancarczyk Monika, Bilińska Barbara
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.353-359, il., bibliogr. 41 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • urologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Among medicinal plants, extract from the hollyhock flowers is a source of antocyanides and flavonoids. The latter coompounds belong, among others, to phytoestrogens (plant-derived dietary estrogens). The important role of estrogens in the testis is now well documented, and phytoestrogens, which may act as estrogen agonists or estrogen antagonists can also alter the reproductive function of the male. The aim of this study was to show whether the exposure of male rats to the aqueous hollyhock extract could affect the process of aromatization in their testes and in cultured Leydig cells. This was investigated by immunocytochemistry and radioimmunological assays. Immunoreactivities for aromatase and estrogen receptor á were weaker both in testicular sections and cultured Leydig cells after hollyhock extract administration when compared to the controls, while the intensity of immunoreaction for estrogen receptor ŕ remained unchanged. A lower level of estradiol secreted by cultured Leydig cells from the experimental group positively correlated with a direct inhibition of aromatase activity. Additionally, a quantitative analysis of flavonoid fraction from the hollyhock extract revealed the presence of quercetin and kaempherol. It seems that a weak antiestrogenic activity of flavonoid compounds present in the hollyhock extract is mediated through aromatase and estrogen receptor á rather than by estrogen receptor ŕ.


    922/2523

    Tytuł oryginału: Immunolocalization of PTHrP in prepubertal and pubertal testis of European bison.
    Autorzy: Czykier Elżbieta, Zabel Maciej, Surdyk-Zasada Joanna
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.373-375, il., bibliogr. 23 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • urologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The present study deals with immunohistochemical localization of PTHrP in prepubertal and pubertal testis of European bison. PTHrP immunoreactivity was observed in germinal cells in the testis of both prepubertal and pubaertal animals. In calves, PTHrP was found in germinal cells, in seminiferous tubules lacking the lumen. The reaction was strong and regularly distributed within the cytoplasm. In adult animals, the reaction showed differentiation in spermatogenic cells. Some cells were strongly and diffusely stained, others exhibited weaker reaction of granular pattern. Sertoli cells and Leydig cells were PTHrP-negative in calves and adult animals.


    923/2523

    Tytuł oryginału: Immunoexpression of nm23 in advanced esophageal squamous cell carcinoma.
    Autorzy: Szumiło Justyna, Skomra Danuta, Chibowski Daniel, Dąbrowski Andrzej, Wallner Grzegorz, Maciejewski Roman
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.377-380, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The study was undertaken to determine the immunoexpression of protein products of nm23 genes which are thought to be potential metastasis suppressor genes, in esophageal squamous cell carcinoma, and to analyze their relationship to selected clinicopathological features (age, sex, tumour size, depth of invasion, presence of lymph nodes and distant metastasis, pathologic tumor stage, degree of cancer differentiation and vascular/lymphatic ivasion), as well as to the overall survival. Immunohistochemical staining with monoclonal antibody against nm23 using LSAB2/HRP method on formalin-fixed, paraffin-embedded sections obtained from 32 tumors was performed. Eight tumors (25 p.c.) showed positive nm23 immunoexpression. There were no statistically significant differences between nm23-positive and nm23-negative groups with respect to all clinicopathological features studied. The positive nm23 status was related to a worse prognosis but this was not significant. The results may suggest that nm23-status is not associated with metastatic ability and prognosis in esophageal squamous cell carcinoma, but such thesis requires further study on a larger population.


    924/2523

    Tytuł oryginału: The effect of pre-eclamptic umbilical cord serum on fibroblast division in culture.
    Autorzy: Pawlicka Elżbieta, Romanowicz Lech, Bańkowski Edward, Chyczewski Lech, Jaworski Stefan
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.381-384, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Edema, proteinuria, hypertension (EPH-gestosis), most commonly termed as pre-eclampsia, is the most common pregnancy-associated pathological syndrome. It is accompanied by a through remodelling of extracellular matrix in the umbilical cord tissues. It is commonly known that the presence of serum in culture medium storngly stimulates many functions of cells cultured in vitro. It was decided to check how the pre-eclamptic serum affects the fibroblast division in culture. Ki-67 is a protein present in proliferating cells and can be detected during all phases of the cell cycle (G1, S, G2/M) but not in resting (GO) cells. PCNA (proliferating cell nuclear antigen) is an intranuclear polypeptide whose synthesis rate is at its maximum during the S-phase of the cell cycle. The expression of Ki-67 and PCNA was measured by immunocytochemical methods and biosynthesis of DNA was evaluated by [14C]-thymidine incorporation. The activity of pre-eclamptic umbilical cord serum (UC-serum) was found to be distincly lower in comparison to control one. The expression of Ki and PCNA in fibroblast cultures treated wtih pre-eclaptic serum was also distinctly lower. Also the incorporation of [14C]-thymidine to DNA was lower than in the cultures treated with control UC-serum. It may by concluded that pre-eclampsia reduces the mitogenic activity of the umbilical cord serum.


    925/2523

    Tytuł oryginału: Iatrogenic Chlamydia infection-associated damage in the basilar arterial wall of the rat.
    Autorzy: Chrapusta Stanisław J., Walski Michał
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.385-387, il., bibliogr. 8 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • choroby zakaźne

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: A random finding of intracranial vascular Chlamydia sp. infection in Wistar rats and its associated damage of the component tissues of the basilar arterial wall are described as seen with transmission electron microscopy. The pathological changes observed showed no apparent specificity except for "striding" of the endothelial cells on the elastic lamina, the phenomenon observed in all five rats with basilar arterial Chlamydia infection, and in only two out of 13 rats with no proof of the infection. No atherosclerotic changes were found in the infected artery in rats sacrificed 8 or 26 weeks after the presumed infection.


    926/2523

    Tytuł oryginału: Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes.
    Autorzy: Frhbeck Gema, Gomez-Ambrosi Javier
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR47-BR55, il., bibliogr. 40 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: In the present study we hypothesized that leptin-induced lipolytic effects show depot-specific differences. Material/Methods: Three-month-old male lean (+/+) and obese fa/fa rats were used. Lipolysis was determined in the absence or presence of leptin (0.63, 6.25 adn 62.5 nM) together with agents acting at the A1 adosine receptor of fat cells isolated from both subcutaneous and omental depots. The glycerol released into the incubation medium was taken as the lipolytic rate index. Results: The highest dose of leptin produced a 57.5 ń 7.3 p.c. and 70.3 ń 3.8 p.c. increase in omental and subcutaneous glycerol release, respectively, compared to the basal lipolytic rate (P 0.001). The addition of the three leptin concentrations in the ligand-free state produced a significantly greater stimulation of lipolysis in subcutaneous fat cells (P = 0.331; P = 0.0003 and P = 0.0015, respectively) compared to omental adipocytes. Under adenosine A1 receptor agonism and antagonism the same pattern of response was observed between visceral and subcutaneous adipocytes of lean rats. Althoug adenosine deaminase produced near maximum lipolysis in the adipocytes of lean animals, onl half of the maximum lipolytic rate (50.9 ń 3.2 p.c.) was achieved in fat cells from fa/fa rats (P = 0.0034). Leptin had no effect on the lipolytic activity of adipocytes from either localization in of/of rats. Conclusion: It can be concluded that decreeased sensitivity to the lipolytic effect of leptin in omental adipocytes compared to subcutaneous fat cells may underlie, at least in part, the association of visceral fat accumulation with increased co-morbidities.


    927/2523

    Tytuł oryginału: Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats.
    Autorzy: Liu Jian-Jun, Wang Ji-Yao, Zhang Chi, Nilsson Ake, Duan Rui-Dong
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR56-BR60, il., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). Material/Methods: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pretreated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-ŕ (TNF-ŕ) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylinand eosin staining. Results: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-ŕ concentration was also increase by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment sigificantly attenuates the effects of endotoxin on BUN, creatnine and TNF-ŕ levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. Conclusion: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC.


    928/2523

    Tytuł oryginału: A prolonged time interval between blood sample collection and centrifugation causes an increase in serum carbohydrate-deficient transferrin.
    Autorzy: Arndt Torsten, Kropf Jrgen
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR61-BR64, il., tab., bibliogr. 3 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Carbohydrate-deficient transferrin (CDT) is used for the laboratory diagnosis of chronic alcohol abuse. Non-optimal preanalysis can cause an increase in CDT and false positive results. The aim of our study was to determine whether CDT results change over time between collection of the blood sample and centrifugation, and whether shipment of whole blood samples is a potential source of false positive CDT reports. Material/Methods: 152 blood samples were drawn from 38 persons (4 tubes per person, one venipuncture) and randomly assigned to 4 groups with different time intervals between blood sample collection and centrifugation (1h, 24h, 48h, 144h). CDT analysis was done using the ChronAlcol.D. assay. The statistical analysis was based on box-plots, ANOVA adn Kruskal-Wallis ANOVA. Results: The means and medians of CDT increased with the time of whole blood storage. ANOVA analysis of between-group differences was significant for mean CDT concentrations between 1 and 144 hours of whole blood storage. There was no correlation between CDT and free hemoglobin as a measure of hemolysis. An interference of hemolysis with CDT measurement can be excluded as the main cause of increased CDT results with whole blood storage time. Whether an in vitro degradation of the transferrin N-glycan chains causes the CDT increase should be evaluated by isoelectric foucusing of the transferrin isoforms in a further study. Conclusion: Storage or shipment of whole blood samples can shift initially normal CDT values to borderline and borderline to pathological CDT results.


    929/2523

    Tytuł oryginału: Antiapoptotic effect of (-)-deprenyl in rat kidney after ischemia-reperfusion.
    Autorzy: Toronyi Eva, Hamar Janos, Magyar Kalman, Szende B‚la
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR65-BR68, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Since apoptosis of renal tubular cells is the damage caused by ischaemia-reperfusion, the antiapoptotic effect on kidney tubular epithelial cells of the monoamino oxidase-B (MAO-B) inhibitor (-) deprenyl (selegiline), known neuroprotective agent, with antiapoptotic properties, was studied in a rat model. Material/Methods: Warm renal ischaemia was caused by clamping the left renal artery of rats for 30 minutes. With the start of reperfusion 0.015 mg/kg, 0.15 mg/kg and 1.5 mg/kb of (-)-deprenyl was injected simultaneously into the carotid artery of the animals, respectively. Five rats severed as control, in which renal artery clamping was performed, but the rats were only treated with the solvent (physiological saline). After 6 hours of reperfusion the rats were exsanguinated and the kidneys were histologically examined. Results: Severe tubular damage characterised by apoptosis was found in the kidneys of the untreated rats. Apoptosis was verified on the basis of morphological features, methylgreen-pyronin staining and TUNEL reaction. (-)-Deprenyl diminished dose-dependetly the apoptotic damage, 0.15 mg/kg being the most effective dose. The same dose of(-)-Deprenyl is used in the therapy of human Parkinson's disease. Conclusion: Our findings suggest, that (-)-deprenyl might have an impact on decreasing renal injury also in cases of human cadaveric renal transplantation.


    930/2523

    Tytuł oryginału: Influence of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome.
    Autorzy: Tesar Vladimir, Zima Tomas, Jirsa jr Milan, Crkovska Jirina, Stipek Stanislav, Vernerova Zdena, Serakova Marketa
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR69-BR74, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Background: The increased permeability of the glomerular capillary wall in adriamycin nephropathy may be mediated by incrased generation of free radicals, possibility also by the non-enzymatic production of isoprostanes induced by oxidative stress. ACE inhiitors and angiotensin II antagonists may reduce proteinuria, perhaps by decreasing intraglomerular pressure and increasing the selective permeability of the glomerular capillary wall. Material/Methods: We compared the effect of an ACE inhibitor, enalapril, and an angiotensin II atagonist, losartan, on total malodialdehyde in blood and the urinary excretion of certain eicosanodids and their metabolites (TxB2, 6-keto-PGF1a, bicyclo-PGE2 and 8-isoprostane) in experimental adriamycin-induced nephrotic syndrome in rats. Results: Increased proteinuria in adriamycin-treated rats was not prevented by losartan, but tended to be partly mitigated by enalapril. However, both losartan and enalapril prevented the adriamycin-induced increase of total MDA in serum, but urinary excretion of 8-isoprostane was increased in nephrotic rats treated by losartan compared to controls. The enalapril-induced increase in urinary excretion of bicyclo-PGE2 was possibly mediated by kinins. Proteiuria positively correlated with urinary excretion of 8-isoprostane, and proteinuric rats also had a significantly higher urinary excretion of 8-isoprostane than non-proteinuric rats. Conclusions: Proteinuria in the acute phase of adriamycine nephropathy may be dependent on free radical generation and the formation of 8-isoprostane. The mild anitproteinuric effect of enalapril, but not losartan, may suggest the contributory role of the inhibiton of kinin degradation in the antiproteinuric action of enalapril in this model of nephrotic syndrome.


    931/2523

    Tytuł oryginału: High affinity glutamate uptake in rat brain slices in experimental crush syndrome.
    Autorzy: Knaryan Varduhi H., Arakelyan Ludmila N., Marouchyan Garegin L., Kevorkian Guevork A.
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR75-BR79, il., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: The pathogenesis of crush syndrome is severe traumatic damage to the organism accompanid by shock and stress, acte toxemia, etc. Glutamate has been shown to be implicated in excitotoxic neural death in various clinical settings. The high affinity glutamate uptake process plays a key role in normal synaptic transmission. The goal of our research was to determine the level of glutamate uptake in brain tissue slices after incorporation of [14C-U]glutamate. Material/Methods: An experimental model of crush syndrome in Wistar male rats was caused by 2 hours of compression of femoral soft tissues using a special press with a force of 100 kg/1 kg of animal weight. Slices were prepared and glutamate uptake was assayed immediately after compression, and again at 2, 24, and 48 hours of decompression. Results: The level of glutamate uptake in cerebral cortex and hypothalamus slices immediately after compression was reduced by 24 p.c. (p 0.05) adn 31 p.c. (p 0.005) respectively. Glutamate uptake in cerebral cortex and hypothalamus was nearly at the same level as the intact group of animals (without compression). In cerebellum slices, glutamate uptake also increased, and in fact exceeded the level in the intact group by 17 p.c. (p 0.025). The level of glutamate uptake decreased in cerebral cortex, hypothalamus, and cerebellum slices by 45 p.c. (p 0.001), 28 p.c. (p 0.001), and 25 p.c. (p 0.001) respectively, compard to the intact group of animals. Conclusion: Experimental crush syndrome promotes the reduction of the glutamate uptake level in brain tissue slices, such the cerebral cortex hypothalamus cerebellum.


    932/2523

    Tytuł oryginału: Minimal distances between temporal bone structures and their mutual correlations.
    Autorzy: Wysocki Jarosław
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR80-BR83, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The minimal distances between basic temporal bone structures limit the operating field in ear surgery. The aim of the present study was to perform measurements on the minimal distances between key structures of the temporal bone and to investigate possible correlations between given structures. Material/Methods: The author remove 100 temporal bones from subjects of both sexes, across a range of age groups and from both sides of the body. Minimal distances were measured between the following structures: the lateral semicircular canal (SC), the tympanic ring (TR), the hard meninges of the middle cranial fossa (HM), the facial nerve (FN), the upper bulb of the internal jugular vein (JB) and the internal carotid artery (CA), collected in the appropriate pairs. The samples were measured using an operating microscope equipped with a graduated eyepiece. Results: The results are presented in various categories according to age, sex, and side of the body. Five pairs of distances were found to be significantly shorter in younger children (group I) than in older children and adults (group II). Conclusions: Ear surgery in younger children demands much more care than in older children and adults, especially regarding situations when the jugular bulb is in the operating field.


    933/2523

    Tytuł oryginału: mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication.
    Autorzy: Schiemann Uwe, Konturek Jan W., Assert Roland, Rembiasz Kazimierz, Konturek Stanisław J., Pfeiffer Andreas
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR53-CR58, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Epidermal growth factor (EGF) receptor ligands (EGFRL) including transforming growth factor alpha (TGF-ŕ), amphiregulin, and heparin binding -EGF (HB-EGF) are involved in gastric mucosal repair in chronic gastritis. Their mRNA expression has been shown to be upregulated after Helicobacter pylori (H. p.)-eradication but little is known about this gene expression in atrophic gastritis. The purpose of our study was to investigate EGFRL mRNA expression in gastric mucosa of patients with atrophic gastritis before and after H. p.-eradication. Material/Methods: Antral mucosal biopsies were obtained during endoscopy in 10 H. p. positive patients with atrophic gastritis and in 10 H. p. negative controls with intact mucosa. Total RNA of antral biopsies was extracted and RT-PCR was performed, the PCR-products being measured densitometrically. Values were compared with mRNA expressions in H. p. negative antral mucosa (n = 10). Results: Gastric biopsies revealed mRNA expression for TGF-ŕ, amphiregulin and HB-EGF, both in H. p. positive atrophic antritis and in H. p. negative healthy mucosa. The mRNA expression of TGF-ŕ in atrophic gastritis was significantly upregulated after H. p.-eradication, whereas that of amphiregulin did not change after this eradication. Expression of HB-EGF mRNA was higher in H.p.-infection than after H.p.-eradication or in H.p. negative healthy subjects. Conclusions: H.p. positive atrophic gastritis is associated with differential mRNA expression of EGF receptor ligands. H.p.-eradication in this entity leads to unequal changes of these growth factor expressions compared to chronic active gastritis without atrophy.


    934/2523

    Tytuł oryginału: Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: Is insulin sensitivity enhanced only in nonobese subjects?
    Autorzy: Poirier Paul, Tremblay Angelo, Broderick Tom, Catellier Claude, Tancrede Gilles, Nadeau Andr‚
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR59-CR65, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: Few studies have evaluated the effect of aerobic physical training on insulin sensitivity in subjects with type 2 diabetes treated with oral hypoglycemic agents. Most studies that invollved nonobese subjects showed enhanced insulin sensiivity whereas studies involving obese subjects with type 2 dibetes are inconsistent because of concomitant fat loss. Material/Methods: Thirteen men with type 2 diabetes (2 nonobese and 7 obese) treated wtih oral hypoglycemic agents carried out a 12-week ergocycle program at 60 p.c. VO2 peak, one hour thrice a week. Diet and medications were maintained throughout the study. Insulin sensitivity was assessed with the euglycemic hyperinsulinemic clamp technique. Results: VO2 peak (ml/kg/min) increased with exercise training. There were no significant changes in fat mass, percent body fat, fasting plasma glucose and insulin levels, glycated hemoglobin levels, or insulin sensitivity. However, when the subjects were separated into two groups, they showed different insulin sensitivity adaptation to training. In fact, nonobese subjects with type 2 diabetes showed an increase in insulin sensitivity, whereas no change was observed in the obese subjects. Conclusions: These findings suggest that moderate aerobic exercise training of 3 months duration enhanced insulin sensitivity only in nonobese men with type 2 diabetes. Obese men with type 2 diabetes showed no benefit. Thus, adiposity per se may be a determining factor in the exercise-induced metabolic benefit of exercise training in subjects with type 2 diabetes.


    935/2523

    Tytuł oryginału: Application of perfluorocarbon liquid in the removal of metallic intraretinal foreign bodies.
    Autorzy: Vartanyan Armen H., Hovhannisyan Tadevos A.
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR66-CR71, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • farmacja
  • okulistyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie angielskie: Background: Virectomy is recognized as one of the best effective methods for removing interetinal foreign bodys, but many authors showed complications during or after removing IOFB. The purpose of our study was to show that the use of perfluorocarbon liquid minimizes complications during pars plana vitrectomy for the removal of metallic intraretinal foreign bodies (IRFBs). Material/Methods: Fourteeen consecutive eyes presenting with penetrating eye injury and intraretinal foreign bodies had previously undergone vitrectomy with injection of perfluorocarbon liquids and removal of IRFBs. In all cases a silicon oil or gas C3F8 tamponade was performed. In one case the removal of the foreign body was combined with repair of retinal detachment using internal tamponade with silicon oil. Results: After a mean follow-up of 16.4 months, 78.5 p.c. of the eyes had recovered better than 20/70 vision, and 92.8 p.c. had attached retina. One patient had endophthalmits and phthisis, and perioperative complications were encountered in two cases. In one case there was a limited hemorrhage, intraretinal, while the other complication was a retinal detachment, which was immediately correctd. In the follow-up period endophthalmitis and lens opcity was found in one patient and epiretinal membrane in another case. These postoperative complications were repaired by additional surgery. Conclusions: The usage of perfluorocarbon liquid is effective for removal of intraretinal foreign bodies and allows to minimize intraopertive complications.


    936/2523

    Tytuł oryginału: Does schistosomiasis interfere with application of the Knodell score for assessment of chronic hepatitis C?
    Autorzy: Shiha Gamal, Zalata Khaled R.
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR72-CR77, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Schistosoma mansoni (SM) is a significant cause of liver disease in many countries. Chronic hepatitis C (HCV) is a worldwide health problem. The association of SM and chronic HCV is not uncommon, especially in areas where both diseases occur. The possible synergistic relationship between them is controversial. Also, the degree of necroinflammatory injury and the state of fibrosis in patients with mixed schistosomias and chronic HCV remains unclear. Material/Methods: 185 individuals were studied: 25 with pure SM, 100 with pure HCV, and 60 mixed HCV and SM (HCV + S), selected from 222 biopsied patients with chronic liver disease treated at the liver unit of the Internal Medicine Department, Mansoura University (July 1999 - May 2000). They were subjected to rectal snip and serological test for schistosomiasis, liver functions, HBV, HCV serological markers, serum qualitative PCR, and liver biopsy. Masson trichrome stain was performed to assess fibrosis. Immuohistochemical staining was performed for HBsAg and HBcAg. The Modified Knodell score was applied to assess the biopsy.


    937/2523

    Tytuł oryginału: Early cardiovascular involvement in patients with systemic sclerosis (SSc).
    Autorzy: Wranicz Jerzy Krzysztof, Zielińska Marzenna, Cygankiewicz Iwona, Dziankowska-Bartkowiak Bożena, Sysa-Jędrzejewska Anna
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR78-CR82, tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacgground. Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin, and by distinctive forms of internal organ involvement. Symptoms usually occur relatively late and are nonspecific, thus often unrecognized. The purpose of our study was to evaluate cardiac function in patients with SSc by means of non-invasive methods in order to detect early dysfunction of the cardiovascular system. Material/Methods: A group of 22 patients with SSc was compared with a group of 22 healthy volunteers. Standard EKG, 24-hour Holter monitoring (HM), and echocardiography were performed in all subjects. Results: In patients with SSc, HM revealed a tendency to tachycardia. Conduction disturbances were observed in 3 patients. In 6 patients significant ventricular arrhythmia was found. Silent ischemia episodes were detected in 6 patients. In HRV analyzis, significantly lower values were detected in patients with SSc than in controls. LPs were present in one patient with SSc, and none in the control gorup. The mean values for QT interval did not exceed the range of normal values. No signs of systolic cardial dysfunction were detected, while in 6 patients left ventricle diastolic dysfunction was recognized. Valvular lesions were observed in 8 patients, but only in 2 patients wer ethey hemodynamically important. Conclusions: 24-hour Holter minitoring and echocardiography enable the early detection of cardiovascukar dysfunction in patients with systemic sclerosis presenting without apparent cardiac impairment symptoms.


    938/2523

    Tytuł oryginału: Clinical signs pointing to the source of hemorrhage in multiple intracranial aneurysms.
    Autorzy: Zderkiewicz Edward, Pawlik Zbigniew, Czochra Marian, Tabora Arkadiusz
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR83-CR86, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In multiple aneurysms of cerebral vessels it is essential to correctly identify the aneurysm that has caused the hemorrhage, since it must be operated first. On the basis of our own material, we have evaluated the usefulness of various clinical signs and examinations in diagnosing which of several aneurysms was the cause of an intracranial hemorrhage. Material/Methods: The material consited of 163 patients with a total of 391 aneurysms. Diagnosis was based on panangiography and neurological examiantions in all cases and CT in the majority. Results.: All the diagnostic examiantions in question (neurological, angiography, CT and intraoperative evaluation) anabled a correct diagnosis in 72.6 p.c. of cases. In CT scanning, diagnostic value diministhes with time. Intracerebral hematoma is the most persistent sign. The highest rupture index a involved aneurysms localized on the anterior communicating artery, while those on the internal carotid artery ranked second. Four patients in whom intraoperative evaluation showed that the order in which the aneurysms wre treated srugically was erroeus died as the result of rebleeding that occurred prior to planned follow-up surgery. Conclusions: It is vitally important for outcome to determine which of several aneurysms has ruptured, since errors in the sequencing of surgical repair significantly increase mortality due to rebleeding preceding the next stage of surgery. When diagnosing the source of a hemorrhage one should take into account neurological findings, angiography, ECG, CT, MRI, and the location of the aneurysms.


    939/2523

    Tytuł oryginału: Is there a relationship between left ventricular systolic function and serum cytokines level in patients with coronary artery disease?
    Autorzy: Mizia-Stec Katarzyna, Mandecki Tadeusz, Zahorska-Markiewicz Barbara, Janowska Joanna, Szulc Andrzej, Jastrzębska-Maj Ewa, Szymański Leszek
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR87-CR92, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: There is growing evidence that cytokines play a pathogenic role in both heart failure and atherosclerosis. The aim of our study was to assess serum levels of selected cytokines and soluble forms of receptors in patients with coronary artery disase (CAD), and the relation between these concentrations and left ventribular (LV) systolic function. Material/Metods: We measured serum levels of TNFŕ, sTNFR 1 and 2, IL-2, and IL-10 in 100 patients with CAD: 70 patients with LV regional wall motion disturbances (group A); and 30 patients with normal LV function (group B). The control group (group C) consisted of 20 healthy volunteers. Results: Mean serum TNFŕ and IL-10 concentrations were significantly higher in groups A (18.3 ń 3.5; 55.4 ń 118.5 pg/ml) and B (17.9 ń 4.9; 45.3 ń 76.8 pg/ml) than in controls (8.3 ń 1.4, p 0.001; 14.3 ń 28.5; p 0.05; respectively). Moreover, in group A serum levels of sTNFR 1 were higher (1367.4 ń 531.1 pg/ml) than in group C (1093,9 ń 456.9 pg/ml; p 0.05). No differences were found in the study groups between serum sTNFR 2 and IL-2 levels. In group A, both the LV ejection fraction and motion score index correlated with TNFŕ (r = -0.277; r = 0.282, p 0.05), and sTNFR 1 levels (r = -0.258; r = 0.280; p 0.05). Conclusion: The serum concentrations of TNFŕ and IL-10 are increased in patients with CAD. Additionally, patients with impaired LV contractility have higher sTNFR 1 concentrations. Serum cytokine activation may play a role in the development of heart failure in patients with CAD.


    940/2523

    Tytuł oryginału: Modified neck dissections - efficiency of surgical treatment and clinical observations.
    Autorzy: Chodynicki Stanisław, Łazarczyk Bogdan, Woińska-Rojecka Teresa, Południewska Barbara, Łuczaj Jarosław, Tynkiewicz Jerzy, Olszewska Ewa
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR93-CR95, il., bibliogr. 5 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The evaluation of affected lymph node number, the site of metastatic lymph nodes, and spread of neoplastic infiltration beyond the lymph capsule is considered useful in prognosis. The aim of the study was to estimate the frequency of neck nodal metastases occurrence depending on the site of origin, the grade of larynx cancer progresssion, and clinical condition of neck lymph nodes. Material/Methods: The study comprised 315 patients with larynx cancer who underwent surgery in 1994-1999. Laryngectomy was the most frequent procedure, performed in 254 patients, while partial laryngectomy was performed in 61 patients. There were 630 bilateral neck dissections; type I of modified radical surgery in 27 cases, type II in 45 cases, and type III in 558 cases. Results: Neck nodal metastases were detected most rarely in cases of glotic cancer (16 p.c.), and most frequently in transglottic cancer (56 p.c.). Most frequently, the nodal metastases affected the II level of the lymph node groups regardless of the site. Recurrences to the neck lymph nodes were observed in 3.3 p.c. of the cases where the removed lymph nodes did not reveal any metastatic changes in histopathological examiantions. Conclusion: Postopeartive results of the neck lymph node histopathological examination point to the necessity of lymphadenectomy in the II-V levels. Selective lymphadenectomy is not advisable due to the possibility of metastases to all lvels of the neck lymph nodes regardles of the primary tumor site.


    941/2523

    Tytuł oryginału: Vitamin C concentration in gastric juice in patients with precancerous lesions of the stomach and gastric cancer.
    Autorzy: Dąbrowska-Ufniarz Elżbieta, Dzieniszewski Jan, Jarosz Mirosław, Wartanowicz Maria
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR96-CR103, il., tab., bibliogr. 66 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to elucidate what are the concentrations of vitamin C in gastric juice in patients with gastric cancer in comparison to patients with metaplasia. Material/Methods: In patients age 20 to 75 years with H. pylori infection and chronic gastritis, metaplasia and gastric cancer the concentration of vitamin C was determined by specrofotometry of gastric juice during gastroscopy. On the basis of the results of histological examination the following four groups were isolated. Group I (control) - 12 patients with normal gastric mucosa, group II - 16 patients with chronic gastritis, group III - 17 patients with metaplasia and group IV - 16 patients with gastric cancer H. pylori infection was confirmed by urease test and histological examination (Giemsa stainning) in all patients. Results: In controls the mean concentration of vitamin C in gastric juice was 18.2 ćg/ml (5.7 - 31.2 ćg/ml), in gorup II - 6.3 ćg/ml (2.9 - 13.1 ćg/ml) in group III - 3.9 ćg/ml (2.6 - 10.1 ćg/ml) and group IV - 3.2 ćg/ml (1.7 - 9.2 ćg/ml). Statistically significant differences of vitamin C concentration were found among group I and group II, III and IV (p 0.001) and among groups II and III and IV (r 0.01). Conclusion: There are not differences of vitamin C concentration in gastric juice between patients with metaplasia and patients with gastric cancer. This points out that low levele of this vitamin in gastirc juice might play the role in the earlier stages of carcinogenesis.


    942/2523

    Tytuł oryginału: Cytomegalovirus infection and atherogenesis.
    Autorzy: Szkaradkiewicz Andrzej, Bogaczyńska-Staniewicz Joanna, Torliński Lech, Wal Marzena
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR104-CR107, tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Background: Experimental studies and clinical observations indicate the importance of active CMV infection in the development of atherosclerosis. Our research constituted an attempt to evaluate the components of lipid metabolism (total cholesterol and its fractions, triglycerides) in children with active CMV infection. Material/Methods: The research involved 45 children with active primary or secondary CMV infection. The diagnosis was established by measuring anti-CMV serum antibodies (IgM and IgG) using the Enzyme-Linked Fluorescent Assay (ELFA) technique, and by detecting CMV-DNA using the PCR technique. On the basis of diagnostic tests, the children were allocated to one of two groups. The first group of 15 children manifested primary active infection with CMV. The other group consisted of 30 children diagnosed with secondary active CMV infection. Results: In the first group, the mean values of the serum lipid profile were as follows: total cholesterol - 142 ń 32.9 mg/dl; HDL-cholesterol: - 23.4 ń 8.6 mg/dl; LDL- cholesterol - 97.8 ń 30.9 mg/dl; triglycerides - 83 ń 15.5 mg/dl. In the second group of children, the mean values of serum lipid profile were as follows: total cholestserol - 142.5 ń 44.2 mg/dl; HDL- cholesterol - 21.4 ń 10.8 mg/dl, LDL-cholesterol - 87.1 ń 35.3 mg/dl; triglycerides - 101.7 ń 31.2 mg/dl. In all these children, the values of total cholesterol, LDL-cholesterol, and triglycerides conformed to published norms, while HDL-cholesterol was significantly belowe normal. Conclusion: The results we obtained point to dyslipidemia in the couse of active CMV infection, which may be of pathognetic significance at any stage of atherogenesis.


    943/2523

    Tytuł oryginału: Serum levels of tissue inhibitor of metalloproteinases 2 in systemic sclerosis: a preliminary study.
    Autorzy: Dziankowska-Bartkowiak Bożena, Waszczykowska Elżbieta, Łuczyńska Maria, Zalewska Anna, Sysa-Jędrzejowska Anna
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR108-CR112, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The etiopathogensis of systemic sclerosis (SSc) - an autoimmunological disease characterized by excess collagen and other connectve tissue components in skin and internal organs - remains unclear. Given the potential role of matrix enzymes, metalloproteinases, and their tissue inhibitors in pulmonary fibrosis, we assayed the serum concentration of tissue inhibitor of metalloproteinases 2 (TIMP-2) in patients with SSc and explored its possible correlation with the duration of Raynaud's phenomenon, the intensity of sclerosis of the skin, and pulmonary lesions. Material/Methods: We studied 18 SSc patients, 8 with limited SSc and ten with diffuse. The degree of sclerosis of the skin was measured using teh Total Skin Scale. Chest x-rays and spirometric examinations were also performed. The presence and type of antinuclear antibodies (ANA) were determined by indirect immunofluorescence and double immunodiffusion in agar gelatin. Serum TIMP-2 concetration was measured by ELISA. Results: The average serum TIMP-2 concentration was not significantly higher in SSc patients than in controls. No statistically significant difference was found in this respect between limited and diffuse SSc. Despite the lack of correlation between the duration of Raynaud's phenomenon, the degree of sclerosis of the skin, and the serum concentration of TIMP-2, the latter concentration was higher in patients with restrictive pulmonary dysfunction in spirometric testing. Conclusion: Our research, though involving a small group of patients, points to the probable role of TIMP-2 in the development of pulmonary fibrosis.


    944/2523

    Tytuł oryginału: Total IgE levels in children under three years of age.
    Autorzy: Malinowska Elżbieta, Kaczmarski Maciej
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR113-CR118, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The course of type 1 allergic reaction is a result of complex immune processes in which immunoglobulin E plays a crucial role. The serum level of this immunoglobulin (IgE total) is closely related to the age of the patient. The presented paper analyses IGE total in children below 3. Material/Methods: The study was carried out in group of 291 patients aged 5 - 39 months. IgE total were determined using the Fluoro-FAST 3M. The analysis took into consideration the age, sex and living place of the examined children. Results: The artmetic mean of IgE total was 38.8 ń 4.0 IU/ml, the median - 12 IU/ml, whereas the 5th and 95th percentile values amounted to IIU/ml and 185 IU/ml, respectively. According to the standards recommended by the manufacturer of reagents used for determination of IgE total (Bio Whittaker), 103 children (35.4 p.c.) had elevated serum levels of IgE total, whereas 196 (67.4 p.c.) were found to have elevated IgE total according to population standards. The obtained percentage distribution of elevated IgE total values in particular age groups is characterized by stepwise changes, observed in the age intervals for which the range of values considered as normal by the manufacturer is chagned. Conclusions: On the basis of analyzed IgE total determinations it has been established that the manufacturere's standards for children aged from 2 to 3 years are overestimated, whereas the population standards seem to be underestiamted. Therefore the determination of IgE total normal value range requires further studies.


    945/2523

    Tytuł oryginału: Evaluation of lymphocyte subsets and NK cells in septic children.
    Autorzy: Wiśniewska-Ligier Małgorzata, Woźniakowska-Gęsicka Teresa, Zeman Krzysztof, Banasik Małgorzata
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR119-CR124, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Disorders of lymphocyte subpopulations counts and NK cells may not only contribute to impaired elimination of pathogens, but also be an important factor in the development of generalized inflammatory reaction. The aim of the paper was the analysis of subpopulations of lymphocytes and NK cells in children with sepsis and after recovery. Material/Methods: The study comprised 25 septic children (17 infants and 8 children aged from 1 to 3 years). The control group consisted of 25 healthy children. The study was conducted in the initial phase of sepsis and then repeated 2 to 3 months after recovery. In all the children, the percentage and absolute numbers of basic lymphocyte subsets and NK cells in blood serum were evaluated. Results: In the course of sepsis, the absolute number of activated lymphocytes T in the youngest children was higher in comparison with the control gorup. After revovery, the percentage and absolute counts of CD4 lymphocytes in all the children and CD3/CD4 lymhocytes ratio in the youngest children were considerably lower than in the control gorup. The percentage and absolute number of NK cells in the youngest children after recovery were higher in comparison with the control group. Conclusions: In children who underwent sepsis, depression traits of cellular immunity are observed. The occurrence of defensive system disorders after recovery may be an important factor in recurrent infections and creates the necessity of immune system monitoring in children with the hisotry of sepsis for the purpose of prevention.


    946/2523

    Tytuł oryginału: Distribution of hepatitis C virus RNA in whole blood of patients with HCV infection and HBV-HCV coinfection.
    Autorzy: Mazurek Urszula, Wilczok Tadeusz, Mazur Włodzimierz, Bednarek Ilona, Strzałka Barbara, Jurzak Magdalena, Laskowska-Lepiarczyk Ewa, Gonciarz Zbigniew
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR125-CR130, tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: Although HCV and HBV are essentially hepatotropic, several lines of evidence suggest that these viruses can infect other cells, also PBMC in most patients with chronic HCV. Material/Methods: The presence of HBV DNA and HCV-RNA was determined by a polymerase chain reaction (multiplex PCR and RT-PCR -nested PCR) in a group of patients with chronic liver disease. HCV-RNA was investigated in serum, plasma and peripheral blood mononculear cells (PBMC) while HBV-DNA only in serum or plasma. Results: Among 374 patients tested, HCB-RNA was detected in the venous blood of 208 patients; HCV RNA alone was detected in 154 patients and 54 patientwere co-infected by HCV and HBV. HBV-DNA was found in 128 of 374 patients, while infection by HBV only was found in 74 patients. It was also shown that in the presence of HBV the replication ability of HCV is lower (p = 0.085, Goodman-Kruskal Gamma = 0.561 and YuleQ = 0.5610). Conclusions: Since coexistence of HBV adn HCV is not a rare cases, diagnostics of hepatitis cannot be limited to detection of one type of the virus only. Nisinterpretation of the virus type that caused the infection may lead to serious complications, especially in those cases when interferone is used for treatment.


    947/2523

    Tytuł oryginału: An open-label study to evaluate the safety, tolerability and efficacy of rivastigmine in patients with mild to moderate probable Alzheimer's disease in the community setting.
    Autorzy: Bilikiewicz Adam, Opala Grzegorz, Podemski Ryszard, Pużyński Stanisław, Łapin Joanna, Sołtys Krzysztof, Ochudło Stanisław, Barcikowska Maria, Pfeffer Anna, Bilińska Małgorzata, Paradowski Bogusław, Parnowski Tadeusz, Gabryelewicz Tomasz
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.PI9-PI15, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Long-term safety and efficacy of Exelon (rivastigmine) was evaluated in a multi-center open label study of 62 patients with probable mild to moderated Alzheimer's disease living in community setting. Material/Methods: The patients started treatment with 1.5 mg bid (3 mg/day) Exelon and were scheduled to receive doses of 1.5 mg bid Exelon escalating on a biweekly basis. The patients were maintained on the highest tolerated dose within the assigned dose range 1.5 - 60.0 mg bid (3 - 12 mg/day) for the rest of the study. Evaluations were scheduled at biweekly intervals for the first 8 weeks and subsequently at study weeks 12, 18 and 26. Effects of Exelon on cognition were evaluated using the mini-mental state examination (MMSE) and selected items of Alzhemier's disease assessment scale (ADAS-cog) and the staging ot the disease was measured using the global deterioration scale (GDS). Safety was monitored by physical examinations, vital signs, laboratory tests, ECG recording and by the assessment of adverse events. Resutls: 55 patients completed the study (89 p.c.). Patients treated for 26 weeks showed the mean MMSE, ADAS-cog and GDS scores close to baseline values (p = NS) with no improvement and no deterioration. Exelon was generally well tolerated with 11 p.c. of patients withdrawing due to adverse events. The most frequently reported adverse events related to the gastrointestinal tract. Conclusions: In conclusion, the study data indicate that treatment with Exelon is safe, generally well tolerated and inhibits the progression of cognitive decline in patients wtih mild to moderate Alzheimer's disease over 26 weeks of treatment.


    948/2523

    Tytuł oryginału: Clinical outcomes of silicon carbide coated stents in patients with coronary artery disease.
    Autorzy: Kalnins Uldis, Erglis Andrejs, Dinne Iveta, Kumsars Indulis, Jegere Sanda
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.PI16-PI20, tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: According to the literature, the stent thrombosis and restenosis rate after coronary angioplasty (PTCA) can be reduced by using stents covered with biologically active substances. The aim of our study was to investigate clinical outcomes of PTCA alone, conventional stainless steel stents, and special Tenax stents covered by amorphous silicon carbide (a-SiC: H). Material/Methods: The study involved a retrospective cohort of 300 patients with coronary artery disease who underwent interventional treatment from 1998 to 2000. One hundred patients received a Tenax stend (BIOTRONIK, Germany) covered by a-SIC: H. For every patient who received a Tenax stent, one patient wit non-Tenax stenting and one patient with PTCA without stenting were randomly assigned. Results: In the Tenax group, 1 p.c. of the patients had an early coronary event due to subacute stent thrombosis, as compared to 2 p.c. in the non-Tenax group and 3 p.c. in the PTCA group. At 6-month follow-up, the difference in the frequency of major adverse cardiac events was more express between the PTCA group and both groups of patients with stents (32 p.c. vs. 20 p.c.; p = 0.053; 32 p.c. vs. 14 p.c.; p = 0.002) in comparison with the 30-day and 3-month results. In the non-Tenax stenting group more events were detected than in the Tenax group (20 p.c. vs 14 p.c.; p = 0.259), but the diffrence was not statistically significant. Conclusion: The results strongly suggest the protective qualities of a-SiC: H stents in reducing early and late coronary events. It can be speculated that Tenax stents attenuate the progression of endothelial growth at the site of intervention.


    949/2523

    Tytuł oryginału: PACAP and VIP in the photoneuroendocrine system (PNES).
    Autorzy: K”ves Katalin, Vereczki Viktória, Kausz Maria, Kantor Orsolya, Molnar Judith, Nemesk‚ri Agnes, Heinzlmann Andrea, Szabó Enik”, Szabó Flóra, Fógel Kristóf, Lakatos Andras, Szeiffert Gabor, Arimura Akira
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.SR5-SR20, il., tab., bibliogr. 91 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The prewsence of PACAP and VIP was demonstrated in all the four levels of the photoneuroendocrine system (PNES) with the use of immunohistochemistry (IHC), radioimmunoassay (RIA), anterograde and reterograde tracing techniques, and cell immunoblot assay (CIBA). Both peptides paly a physiological role in the PNES. According to our results both PACAP and VIP are involved in the regulation of the gonadotrop hormone secretion and their inhibitory role may be mediated through the neuronal chain of the PNES. Abbreviations: CIBA - cell immunoblot assay, CRF - corticotrop hormone-releasing hormone, FG - fluorogold, FSH - follicle stimulating hormone, GRP - gastrin releasing peptide, HRP - horse-radish peroxidase, icv - intracerebroventricular, IHC - immunohistochemistry, iv - intraveous, LH - luteinizing hormone, LHRH - luteinizing hormone-releasing hormone, ME - median eminence, MSG - monosodium glutamate, PACAP - pituitary adenylate cyclase activating polypeptide, PhA-L - Phaseolus Vulgaris Leucoagglutinin, PHI - peptide histidine isoleucine, PNES - photoeuroendocrine system, PVN - paravetricular nucleus, RIA - radioimmunoassay, sc - subcutaneous, SCN suprachiasmatic nucleus, SON - supraoptic nucleus, VIP - vasoactive intestinal polypeptide.


    950/2523

    Tytuł oryginału: The course of vision disturbances in a patient with the MELAS syndrome.
    Autorzy: Pachalska Maria, DiMauro Salvatore, Formińska-Kapuścik Maria, Kurzbauer Henryk, Talar Jan, MacQueen Bruce Duncan, Pawlicka Iwona, Jeleńska-Szyguła Irena
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CS11-CS20, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: This article describes the neuropsychological and ophthalmic symptoms presented by a patient with MELAS, a mitochondrial cytopathy. This rare disease is characterized by a remitting-relapsing course against the background of a slowly progressive degenerative process. Case report: The patient is a 22-year-old Polish female, with initial onset of symptoms in 1994; the clinical diagnosis of MELAS was established in 1998, and confirmed in 2000 by the discovery of a novel mtDNA mutation. Her visual acuity fluctuates from near-normal to near-blindness, often changing dramatically within a matter of weeks; the visual field has more or less steadily narrowed to lunate. Visual evoked potentials show sporadic distrubances, while the nerve fiber layer shows significant attenuation. The evidence points to a complex etiology, involving both cortical damage and attenuation of the optic nerves and neural pathways. A similar two phase pattern - episodic disturbances with rapid spontaneous revovery against a background of progressive deterioration - occurs in neuropsychological testing, which reveals progressive dementia and episodic aphasia. Conclusions: The peculiiar pathomechanism of MELAS results in simultaneous insults to various parts of the central and peripheral nervous systems, creating the complex and highly variable pattern seen in this patient. In clinical practice care should be taken not to overlook the possible significance of such a pattern appearing in various systems and on varying levels.


    951/2523

    Tytuł oryginału: Tumor markers in metastatic disease from cancer of unknown primary origin.
    Autorzy: Milović Marijana, Popov Ivan, Jelić Svetislav
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.MT25-MT30, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: About 5 - 10 p.c. of cancer patients suffer from cancer of unknown primary (CUP). Sopisticated diagnostic techniques have not improved diagnostic efficacy for these patients. The aim of our analysis was to evaluate serum levels of four tumor markers and to relate them to the histology, number, and sites of metastases, the response to chamotherapy, and survival. Material/Methods: Blood samples from 46 patients with CUP were assayed for CEA, CA 19-9, CA 15-3 and CA 125. Specific IMx tumor marker assays (Abbott) were used to measure tumor marker quantities. Results: No significant differences were detected between the mean levels of all markers for the two histological types (adenocarcinoma vs. undifferentiated carcinoma). The comparison of tumor marker values in patients with one metastatic location to those with two or more showed no significant differencnes. We found no differences in marker values between patients with disease sites in the thorax vs. those with abdominal metastases. The comparison of marker negative, CEA positive and non-CEA positive patients failed to reveal significant differences in response rate. The comparison of CEA positive and marker negative patients showed significant differences in survival (log-rank, p = 0.02). Conclusion: Our results suggest that patients with CUP have a nonspecific overexpression of serum tumor markers and that routine use of these markers does not offer diagnostic assistance. Neverthelless, the pattern of expression of some biological markers, such as CEA, could have prognostic significance for survival.


    952/2523

    Tytuł oryginału: Dynamic MR imaging of soft tissue tumors with assessment of the rate and character of lesion enhancement.
    Autorzy: Tacikowska Małgorzata
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.MT31-MT35, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The aim of this study was to analyze the diagnostic usefulness of dynamic MRI with determination of the coefficient of enhancement rate and the character of tumor enhancement, and to assess both parameters in the differentiation of malignant lesions. Material/Methods: The material consisted of 45 patients (30 sarcomas, 15 non-malignant lesions), age 16 - 64 years. MRI was done usin an Elscint 2T unit, gradient echo techniques, apex angle 80ř. The repetition time (TR) was 80 - 200 ms, the echo time (TE) was 2 - 6 ms, I excitation; the acquisition time (TA) was 70 - 80 ms. The coefficient of tissue enhancement rate was calculated in the region of interest, and expressed as percent per second (erc p.c./s.) The limit value of erc p.c./s was determined. The sensitivity and specificity of MRI were calculated in the differentiation of malignant tumors. The method of contrast filling of the tumors was assessed in successive phases after administration of gadolinium Gd-DTPA. Results: Dynamic MRI with determination of the index of tumor enhancement rate is highly sensitive (93 p.c.) and specific (73 p.c.) in the differentiation of malignant and benign lesions. The usefulness of the assessment of tumor enhacnement character was not confirmed, since the sensitivity and specificity wre 73 p.c. and 33 p.c. Dynamic MRI with determination of erc p.c./s and tumor enhancement character is highly sensitive (93 p.c.) and specific (87 p.c.). Conclusions: Dynamic MRI with determination of erc p.c.; s and tumor enhancement character is the best method for differential diagnosis.


    953/2523

    Tytuł oryginału: MR proton spectroscopy in liver examinations of healthy individuals in vivo.
    Autorzy: Tarasów Eugeniusz, Siergiejczyk Leszek, Panasiuk Anatol, Kubas Bożena, Dzienis Wojciech, Prokopowicz Danuta, Walecki Jerzy
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.MT36-MT40, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Magnetic resonance proton spectroscopy (1H MRS) is a non-invasive method that provides in vivo measurement of metabolic concentrations in body tissue. However, relatively little is known about the potential of 1H MR spectoscopy fot the qualification of liver metabolites. The aim of this study was to determine the usefulness of 1H MRS in establishing the metabolic pattern of normal human liver. Material/Methods: Proton specrtoscopy of the liver, using the Picker system, Edge Eclipse 1.5T, with whole-body coil and PRESS 35 sequence, was conducted in a group of 24 healthy volunteers. In all subjects we also evaluated the thckness of the subcutaneous fat tissue in MR images and body mass index. Results: The presence of lipid resonances, phosphoesters (Pe), glycogen/glucose (Glc), and glutamine/glutamate (Gln) were observed in the spectra. Total lipid concentration, CH3 and (CH2)n of the lipid resonancs were higher in the men than in the woemn, while the metabolite contents in the CH2=CH-CH2 gorups of lipids, Pe, Glc and Bln peaks were similar in both genders. We observed statistically significant positive correlation, more apparent in the gorup of men, between TL concentration and BMI. There was no statistically significant correlation between lipid total concentration and age. Conclusion: Proton spectorscopy enables the quantitative evaluation of lipid contents in the liver. The correlation between liber triglyceride contents and body mass ndex shows that the tendency to obesity is also connected with lipid accumulation in the liver.


    954/2523

    Tytuł oryginału: Tonal nitric oxide and health: anti-bacterial and -viral actions and implications for HIV.
    Autorzy: Benz Danielle, Cadet Patrick, Mantione Kirk, Zhu Wei, Stefano George B.
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.RA27-RA31, tab., bibliogr. 46 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • aIDS
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Nitric oxide has been shown to have important physiological regulatory roles, i.e., vasodilation, neurotransmitter release, etc. Now, we review its role as an antibacterial and antiviral agent. Nitric oxide has also been identified as an improtant factor in the development of nonspecific immunity. And accordingly, nitric oxide synthase (NOS), the catalytic wnzyme producing nitric oxide, is a key element in the protective activities of nitric oxide. The expression of inducible (i) NOS is regulated by cytokines. iNOS-derived nitric oxide was found to contribute to both early and late phases of antibacterial activity. Enzymes, such as proteases (reverse transcriptases, and ribonucleotide reductase, etc.) containing cysteine residues, appear to be targets for nitric oxide nitrosylation, as well as viral-encoded transcription factors that are involved in viral replication. It would appear than thiss multifunctional signaling molecule is not only involved with signaling between cells, it also appears to maintain the immediate environment free of microbial agents.


    955/2523

    Tytuł oryginału: Hepatocyte proliferation in health and in liver failure.
    Autorzy: Rozga Jacek
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.RA32-RA38, il., bibliogr. 58 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Mammalian liver possesses an extraordinary capacity for compensatory growth in response to conditions that induce cell loss by physical, infectious, or toxic injury. In normal animals and humans, it is a tightly regulated process of both hypertrophy and hyperplasia involving different liver cell populations and a finely tuned interplay between growth factors, cytokines, extracellular matrix components and other regulators. The regeneration response is maximal when two-thirds of teh liver is resected. When a lesser amount of parenchyma is removed, residual liver grows more slowly. Resections exceeding two-thirds of the liver mass also retard andn diminish both DNA synthesis and mitotic activity and subtotal (90 p.c.) hepatectomy invariably results in the death of rats without regeneration. The underling mechanicms of liver growth inhibition are poorly understood. In particular, only a few studies exist that provide insight into the mechanisms that control regeneration after extensive heaptocyte loss. In this regard, the role of growth-regulatory factors and other compounds that accumulate in the blood circulation as a result of hepatic insufficiency and liver cell death remains unclear. We have initiated studies of these mechanisms and demonstrated that in rats with low (10 p.c.) hepatocyte mass, a marked and sustained elevation of blood IL-6, HGF adn TGF-á1 levels was associated with lack of heaptocyte proliferation and suppression of Stat3 DNA binding. While searching for the possible cause of inhibited IL-6/Stat 3 signaling, we found that IL-6 receptor (IL-6R & gp130) was preserved, that nuclear Stat3 protein content was lowered, and that IL-6/Stat3 pathway inhibtors (SOCS-1, PIAS3) were induced during the pre-replicative Go-G1 period.


    956/2523

    Tytuł oryginału: Regulation of renal tubular sodium transport by cardiac natriuretic peptides: two decades of research.
    Autorzy: Bełtowski Jerzy, Wójcicka Grażyna
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.RA39-RA52, il., bibliogr. 188 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: This review presents the current state of our knowledge regarding the regulation of renal tubular sodium transprot by natriuretic peptides, with special emphasis on recent findings in this field. Natriuretic peptides constitute a complex system involved in the regulation of sodium balance and blood pressure. The natriuretic peptide family consists of atrial peptides, such as atrial natriuretic factor (ANF, ANP90-126), long-acting natriuretic peptide (ANP1-30), vessel dilator (ANP31-67) andn kaliuretic peptide (ANP79-98), as well as brain or B-type natriuretic peptide (BNP), C-type natriuretic peptide (CNP) and urodilatin. Natriuretic peptides act on target cells through A-type and B-type receptors and stimulate cyclic GMP synthesis. ANF stimulates natriuresis mainly by inhibiting soidum reabsorption in the inner medullary collecting duct. The effect results from coordinate inhibition of apical sodium channels and basolateral Na+, K+-ATPase. Additional effects on sodium transport occure in more proximal nephron segments and on glomerular filtration when hormone concentration is elevated. BNP and urodilatin share the same mechanism of action. CNP synthetized in several nephron segments acts through specific B-type natriuretic peptide receptors, which are also expressed in renal tubule, but have a different distribution than A-type receptors. ANP1-30, ANP51-67 and ANP79-98 decrease Na+, K+-ATPase activity in tubular cells through a prostaglandin E2-deendent mechanism.


    957/2523

    Tytuł oryginału: Bakers' asthma - how far are we from prevention?
    Tytuł polski: Astma piekarzy - jak daleko do prewencji?
    Autorzy: Walusiak J[olanta], Pałczyński C.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.5-7, bibliogr. 22 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Astma piekarzy wciąż należy do najczęstszych chorób zawodowych. Autorzy omawiają aktualne problemy dotyczące alergii zawodowej dróg odechowych u piekarzy, ze szczególnym uwzględnieniem czynników ryzyka i zależności pomiędzy występowaniem objawów alergicznych a poziomime narażenia.


    958/2523

    Tytuł oryginału: A case of Churg-Strauss syndrome and montelukast therapy.
    Tytuł polski: Przypadek zespołu Churga-Strauss i leczenie montelukastem.
    Autorzy: Świerczyńska M., Mastalerz L., Niżankowska-Mogilnicka E.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.9, 11-12, bibliogr. 10 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie polskie: W pracy przedstawiono przypadek 28-letniego chorego z zespołem Churga-Strauss (Churg-Strauss syndrome, CSS), który pojawił się w trakcie leczenia montelukastem. Pacjent został przyjęty z powodu duszności astmatycznej, gorączki i kaszlu. Przy przyjęciu stwierdzono leukocytozę oraz eozynofilię. W badaniu radiologicznym klatki piersiowej stwierdzono nacieki w górnych i środkowych polach płucnych. Biopsja oskrzela była prawidłowa. W popłuczynach pęcherzykowo-oskrzelowych wykazano Citobacter freundii. Ze względu na hipereozynofilię rozpatrywano wiele jej przyczyn, w tym również CSS, objawy nie spełniały jednak wszystkich kryterów diagnostycznych CSS. Ostatecznie rozpzonano astmę alergiczną oraz bakteryjne zapalenie płuc. Do leczenia włączono antybiotyki oraz steroidy doustne. Stan chorego uległa poprawie i nacieki płucne cofnęły się. Po wypisie dawki steroidów doustnych stopniowo zmniejszano, a następnie zamieniono na steroidy wziewne. Po 6 miesiącach od wypisu rozpoczęto leczenie montelukastem. W trakcie terapii tym lekiem stan chorego uległ pogorszeniu i pojawiły się objawy pozapłucne. Zespół Churga-Strauss potwierdzono przez biopsję zmian skórnych. Do leczenia włączono doustne steroidy z dobrym skutkiem. W dyskusji omówiono możliwe przyczyny coraz częstszego pojawiania się przypadków CSS w trakcie terapii lekami przewciwleukotrienowymi.


    959/2523

    Tytuł oryginału: Cells and mediators in nasal and bronchoalveolar lavage fluid from patients with occupational asthma due to diisocyanates.]
    Tytuł polski: Komórki i mediatory w popłuczynach nosowych i oskrzelowo-pęcherzykowych u chorych na astmę oskrzelową wywołaną przez izocyjaniany.
    Autorzy: Krakowiak A[nna], Pałczyński C., Walusiak J., Ruta U., Wittczak T., Gruchała J.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.13-19, il., tab., bibliogr. 24 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: W badaniu brało udział 30 osób chorych na astmę oskrzelową zawodowo narażonych na izocyjaniany. U każdego pacjenta przeprowadzono wywiad chorobowy, badanie przedmiotowe, wykonano punktowe testy skórne, oznaczono całkowite stężenie IgE w surowicy i występowanie antygenowo swoistych przeciwciał IgE oraz badanie spirometryczne. Dodatkowo analizowano zmiany w składzie morfologicznym i biochemicznym oraz stężenia mediatorów w popłuczynach nosowych i oskrzelowo-pęcherzykowych przed i 25 h po prowokacji izocyjanianami i placebo. Średnia wartość całkowitego stężęnai IgE wynosiła 4r kU/I, u 10 osób stwierdzono IgE antygenowo swoiste. Występowanie podwójnej reakcji alergicznej odnotowano u 10 osób, zaś u pozostałych potwierdzono izolowaną reakcję późną po prowokacji izocyajnianami. Jedna osoba skarżyła się na objawy nieżytu nosa po prowokacji. Znamienny statystycznie wzrost odsetka eozynofilów i neutrofilów oraz albumin odnotowanoe w popłuczynach nosowych i oskrzelowo-pęcherzykowych w 25 h po prowokacji izocyjanianami. Nie obserowowano istotnych zmian w zakresie analizowanych parametrów po prowokacji placebo. Prowokacji wziewna izocyjanianami wywołała podobne zmainy zarówno w składzie komórkowym, biochemicznym, jak i w zmianach stężeń medatorów w górnych i dolnych drogach; reakcją alergiczną najczęściej odnotowywana po prowokacji izocyjanianami była izolowana późna reakcja alergiczna.


    960/2523

    Tytuł oryginału: The evaluation of neutrophils functions in patients with atopic dermatitis.
    Tytuł polski: Przydatność oceny czynności granulocytów obojętnochłonnych u chorych na atopowe zapalenie skóry.
    Autorzy: Samochocki Z[bigniew], Zabielski S., Paluchowska E.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.20-24, tab., bibliogr. 28 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Nawrotowe zakażenia bakteryjne skóry są cechą atopowego zapalenia skóry (AZS). Jedną z przyczyn tego zjawiska mogą być zaburzenia czynności PMN. Celem pracy była ocena zdolności granulocytów obojętnochłonnych (polymorphonuclear, PMN) krwi obwodowej i puli skórnej do migracji, redukcji i pochłaniania oraz ocena przydatności tych testów w przewidywaniu przebiegu AZS. Badaniami objęto 32 chorych na AZS (f18 K, 14 M, w wieku średnio 23,6 ń 6,2 lat) i 32 osoby zdrowe (13 K, 19 M, w wieku średnio 23,4 ń 2,7 lat). Ocenę czynności granulocytów obojętnochłonnych skóry i krwi obwodowej dokonano metodą Clausena na podstawie ich zdolności do spontaniczenj migracji oraz redukcji NBT i pochłaniania lateksu - testem Parka. Uzyskane wyniki poddano analizie statystycznej. Stwierdzono, że u chorych a AZS obserwuje się częściowe zaburzenie funkcji PMN, czego wyrazem jest ich zmniejszone zdolność do spontanicznej migracji. Określenie tego parametru może być pomocne w rozpoznawaniu AZS, natomiast nie jest przydatne w prognozowaniu przebiegu choroby. Podwyższona wartość testu NBT granulocytów tylko puli skórnej może przemawiać za zachowaną ich zdolnością bakteriobójczą i świadczyć o ich pobudzeniu zależnym od kolonizacji bakterii na powierzchni skóry.


    961/2523

    Tytuł oryginału: Interrelation of cytokines and their association with acute phase proteins in Hodgkin's disease and in rheumatoid arthritis.
    Tytuł polski: Współzależność cytokin i ich związek z białkami ostrej fazy w chorobie Hodgkina i reumatoidalnym zapaleniu stawów.
    Autorzy: Karter Y[esari], Uzun H., Tunckale A., Aydin S., Ertrk N. T., Aran S., Yaldiran A., ™ztrk E.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.25-28, tab., bibliogr. 16 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • hematologia
  • onkologia
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Kilka cytokin uznano za silne immunologiczne mediatory w chorobie Hodgkina (HD) i w reumatoidalnym zapaleniu stawów (RA). Wykorzystując metodę ELISA określono stężenia cytokin -IL-1á, IL-6, TNFŕ i białek o strej fazy, a w tym CRP, á2-mikrogloulinę, ceruloplazminę, ferrytynę, fibrynogen i haptoglobinę w grupie chorych z HD nieleczonych (6 kobiet, 7 mężczyzn, śr. wiek 34 +/- 16) i z RA (7 kobiet i 5 mężczyzn, śr. wiek 43 +/- 12). Charakteryzowali się oni zwiększonym wskaźnikiem opadania erytrocytów (102,60 +/- 23 mm/h i 103,72 +/- 15,09 mm/h - odpowiednio.Poszukowano koreloacji i związku badanych cytokin z białkami ostrej fazy. W analizie statystycznej zastosowano metodę ANOVA i metodę korelacji. Stężenia IL-1 zaró no u chorych na HD (f26,17 +/- 33,00 pg/ml), jak i z RA (26,04 +/- 22,67 pg/ml) były znamiennie większe niż w grupie kontrolnej (3,58 +/- 0,15 pg/ml) (p 0.001). Średnie stężeneia IL-6 i TNFŕ u chorych na HD wynosiły 89,6 +/- 104,36 pg/ml i 77,52 +/- 32,14 pg/ml - odpowiednio, przy wartościach w grupie kontrolnej 3,53 +/- 0,93 pg/ml i 6,35 +/- 2,29 pg/ml (p 0,001). Podobnie u chorych na RA wartości IL-6 wynosiły 66,52 +/- 109,32 pg/ml TNFŕ 71,30 +/- 18,60 pg/ml. U chorych na HD stężenia á2-mikroglouliny (5,83 +/- 5,26 mg/l), CRP (9,25 +/-5.69 mg/l) i haptoglobiny (370,12 +/- 326,19 mg/dl) były znamiennie większe. Podobne zmainy stwierdzono u chorych na RA, u których stężenie á2-mikroglobuliny (6,58 +/- 7,89 mg/l), CRP (9,98 +/- 5.36 mg/l), ceruloplazminy (66,50 +/- 88,85 mg/dl) i fibrynogenu (483,09 +/- 173,72 mg/dl) były rówież znamiennie większe. Wykazano liniową korelację...m


    962/2523

    Tytuł oryginału: Studies on IL-6, IL-8, bFGF, sTNFRI, sTNFRII and sIL-2R in serum of patients with colorectal cancer.
    Tytuł polski: Badania IL-6, IL-8, bFGF, sTNRFI, sTNFRII i sIL-2R w surowicy chorych na raka jelita grubego.
    Autorzy: Grotowski M[aciej], Piechota W. N., Maruszyński M.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.29-35, il., tab., bibliogr 28 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Cytokiny są grupą mediatorów o zazwyczaj krótkim szeregu białka, które odgrywają ważną rolę w rozwoju, działaniu i kontroli komórek odporności i wielu innych układów. Ekspresja cytokin w surowicy u chorych na nowotwory złośliwe przewodu pokarmowego wciąż nie jest dobrze poznana. Celem pracy było zbadanie w surowicy u chorych na gruczolakoraka jelita grubego przedoperacyjnych stężeń IL-6, IL-8, podstawowego czynniak wzrostu fibroblasta (vFGF) i rozpuszczalnych (s) receptorów (R) czynnika martiwcy guza - TNF (sTNFRI i sTNFRII) oraz IL-2 (sIL-2R). Oceniano również czułość badanych czynników i związek między ich stężeniami a stopniem zaawansowania nowotworu. Badaniem objęto 81 chorych z rozpoznanym histologicznie przed operacją gruczolakorakiem jelita grubego (grupa chorych na raka) oraz 40 zdrowcyh ochotników (grupa kontrolna). Badane czynniki mierzono, stosując zestaw ELISA. Używając metody percentylowej, w oparciu o wyniki grupy kontrolnej obliczano czułość badanych czynników. Stwierdzono, że w grupie chorych w surowicy występowało zanczące zwiększenie ich stężenia, które wynosiło: IL-6 - 5,9, IL-8 - 4,4, bFGF - 3,4, sTNFRI - 1,5, sTNFRII - 1,4 i sIL-2R - 2,0 pg/ml i były 2-krotnie większe w porównaniu z grupą kontrolną (p 0,001). Wartości graniczne w grupie kontrolnej wynosiło: IL-6 - 4,5; IL-8 - 21,1; bFGF - 6,25; sTNFRI - 2254; sTNFRII - 3010 i sIL - 2R - 1676 pg/ml. Czułość IL-6 wynosiła 37 proc., IL-8 - 65,4 proc., bFGF - 25,9 proc., sTNFRI - 30,9 proc., sTNFRII - 50,6 proc. i SIL-2R 71, 6 proc. Stężenia IL-6, IL-8 i sIL-25 dobrze korelowały z progresją nowotworu (p 0,05). Oznaczenie poziomów...


    963/2523

    Tytuł oryginału: Comparison of CEA, IL-6, IL-8, bFGF, sTNFRI, sTNFRII and sIL-2R levels in serum of colorectal cancer patients.
    Tytuł polski: Porównanie stężeń antygenu CEA, IL-6, IL-8, bFGF, sTNFRI, sTNFRII i sIL-2R w surowicy u chorych na raka jelita grubego.
    Autorzy: Grotowski M[aciej], Piechota W. N.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.36-43, tab., bibliogr. 26 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Antygen CA jest najpowszechniej używanym antygenem u chorych na raka jelita grubego do rozpoznawania i monitorowania przebiegu choroby. Jego ograniczona czułość i swoistość powodują, że jest zbyt słaby do wykrywania wczesnych postaci tego nowotworu. Ostanio liczne badania zwróciły uwagę na czynniki regulujące odporność, które mogą ułatwić wzrost nowotworów. W tym badaniu analizowaiśmy przedoperacyjne stężenia antygenu CEA, interleukin (IL-6 i IL-8), podstawowego czynnika wzrostu fibroblasta (bFGF) oraz rozpuszczalnych receptorów czynnika martwicy guza (sTNFRI i sTNFRII) i IL-2. Określaliśmy ich czułość oraz współzależność między zasięgiem ich wzrostu a czynnikami kliniczno-patologicznymi. Porównywaliśmy też częstość występowania dodatnich wyników antygenu CEA, badanych cytokin i rozpuszczalnych receptorów. Badaniem objęto 81 chorych na raka jelita grubego (grupa z rakiem) oraz 40 zdrowych osób (grupa kontrolna). Stopień zaawansowaniaai nowotworu oceniano wg klasyfikacji Dukes'a. Stężenia antygenu CEA mierzono w grupie z rakiem używając kitów MEIA. Za górną granicę normy przyjęto wartość 3 ng/ml. W obu gruchach stężenie cytokin i rozpuszczalnych receptorów mierzono używając kitu ELISA. W oparciu o wyniki grupy kontrolnej ustalono normy dla badanych cytokin i rozpuszczalnych receptorów oraz określono ich czułość. Czynnikami kliniczno-patologicznymi były: płeć, wiek, typ histologiczny, przerzuty do wątroby, rozsianie otrzewnowe, zajęcie węzłów chłonnych, umiejscowienie nowotworu, trwanie objawów i stopnie Dukes'a. Ekspresja antygenu CEA, IL-8 oraz sIL-2R dobrze korelowała z analogicznymi...


    964/2523

    Tytuł oryginału: Investigations on the role of immunological factors in aseptic loosening of total cemented and uncemented hip prosthesis. [P.] 3: Morphological investigations.
    Tytuł polski: Badania nad rolą czynników immunologicznych w obluzowaniu aseptycznym całkowitej cementowej i bezcementowej protezy stawu biodrowego.
    Autorzy: Denys P[aweł], Szmigiel A., Żołyński A.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (1) s.44-49, il., bibliogr. 21 poz., sum.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Dokumentacja morfologiczna obejmuje wyniki badań histopatologicznych uzyskanych w mikroskopie świetlnym, wyniki badań immunohistochemicznych i mikroskopowo-elektronowych. Potwierdzono opisywane w piśmiennictwie aktywacje i proliferacje makrofagów wokół mas martwiczych i fragmentów polietylenu. Znaleziono także dane potwierdzające udział komórkowych reakcji immunologicznych w procesie obluzowania protezy: obecność komórek limfocytarnych i plazmocytów w tkankach strefy styku protezy.


    965/2523

    Tytuł oryginału: Significant variations of responsiveness of rat gut smooth muscles to glutamate.
    Autorzy: Milovanovic Dragan R., Matovic Milovan, Milicic Biljana, Jankovic Slobodan M.
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.507-511, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Our four-year study, conducted on isolated rat stomach and rectum strips from adult rats of the same brood in five series, demonstrated for the first time notable variations of the responsiveness of the gut smooth muscles to glutamate, the findings that point to strong variability of glutamate contractile action which could lead to inconsistencies and should be taken into acount in the future research.


    966/2523

    Tytuł oryginału: Azathioprine-induced fatal macrocytic anemia in rabbits.
    Autorzy: Al-Safi Saafan, Tashtoush Bassam, Abdul-Razzak Khalid
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.513-516, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Azathioprine (AZA) is used clinically sometimes at high doses for short-term therapy to treat acute rejection of kidney allograft or to desensitize hypersensitive patients to it. The delayed consequences of this approach had not been well investigated. Therefore, in this study we have investigated the delayed consequences of high-dose short-term AZA administration in rabbits. Our results showed that oral administraton of AZA (10 mg/kg/day) to rabbits for two weeks induced reversible thrombocytosis and delayed fatal macrocytic anemia. Moreover, neither the hemoglobin level nor the the white blood cell count was affected by AZA. The solvent of AZA had no effect onblood cell counts and hemoglobin levels. We can conclude that although high-dose AZA therapy may not induce immediate and significant changes in blood picture, delayed fatal macrocytosis may occur.


    967/2523

    Tytuł oryginału: SIB 1893 possesses pro- and anticounvulsant activity in the electroshock seizure threshold test in mice.
    Autorzy: Łuszczki Jarogniew, Borowicz Kinga K., Czuczwar Stanisław J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.517-520, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: SIB 1893, a non-competitive antagonist of group I metabotropic glutamate receptor sutype 5, administered at the doses ranging between 0.5 - 2 mg/kg markedly lowered the electorconvulsive thershold, whereas if applied at the higher dose of 40 mg/kg, it significantly raised the threshold for electroconvulsions in mice, exhibiting both pro- and anticonvulsive properties in this test.


    968/2523

    Tytuł oryginału: Electroconvulsions elevate the levels of lipid peroxidation products in mice.
    Autorzy: Rola Radosław, Świąder Mariusz, Czuczwar Stanisław J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.521-524, il., bibliogr. 14 poz., sum.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The objective of this study was to determine whether electroconvulsions lead to excessive lipid peroxidation. The concentrations of the conjugated dienes (CD) and malonyl dialdehyde (MDA) in the homogenates of the brains after seizures induced with 25 mA current (MES) measured immediately after seizures were significantly higher in comparison with the control brains. There were no significant differences between control group and animals treated with multiple MES. Significant rise in CD concentrations was also observed at 1 h following MES. The results indicate that electroconvulsions may lead to the increased formation of lipid peroxidation products.


    969/2523

    Tytuł oryginału: VIII Conference on: Ethanol-drug interactions and pharmacological treatment of alcohol dependece, Łódź, October 18, 2002 - [abstracts].
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.525-548 - 8 Konferencja pt. Interakcje etanol-lek i farmakologiczne leczenie zależności alkoholowej Łódź 18.10. 2002
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • króliki
  • szczury


    970/2523

    Tytuł oryginału: Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients.
    Autorzy: Rejdak Konrad, Bartosik-Psujek Halina, Dobosz Beata, Kocki Tomasz, Grieb Paweł, Giovannoni Gavin, Turski Waldemar A., Stelmasiak Zbigniew
    Źródło: Neurosci. Lett. 2002: 331 (1) s.63-65, il., bibliogr. 16 poz.
    Sygnatura GBL: 305,936

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The present study was undertaken to measure cerebrospinal fluid (CSF) levels of kynurenic acid (KYNA) in patients with relapsing-onset multiple sclerosis (MS) during remission or not progressing for at least 2 months. In these patients the levels of CSF KYNA were found to be significantly lower compared with subjects with non-inflammatory neurological diseases, as well as those with inflammatory disease (median interquartile range): 0,41 (0.3 - 0.5) pmol/ml, n = 26 vs. 0.67 (0.5 - 1.1), n = 23, P 0.01 and 1.7 (1.5 - 2.6), n = 16, P 0.001, respectively). These results provide further evidence of the alterations in the kynurenine pathway during remitting-onset MS.


    971/2523

    Tytuł oryginału: Successful treatment of leukaemia cutis with cladribine in a patient with B-cell chronic lymphocytic leukaemia.
    Autorzy: Robak E[wa], Robak T[adeusz], Biernat W[ojciech], Bartkowiak J[acek], Krykowski E[uzebiusz]
    Źródło: Br. J. Dermatol. 2002: 147 (4) s.775-780, il., bibliogr. 27 poz.
    Sygnatura GBL: 300,728

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Cutaneous presentation of B-cell chronic lymphocytic laukaemia (B-CLL) is uncommon, and the influence of skin changes on B-CLL prognosis is unclear. We report a patient with B-CLL Rai II, with multiple nodular skin infiltrations on the trunk, arms and thighs as well as constitutional symptoms, who was successfully treated with cladribine. The peripheral blood (PB) lymphocytes were CD19, CD20, Cd23 and CD5 positive, which confirmed the diagnosis of B-CLL. Skin biopsy of one of the lesions showed an intense infiltrate composed of small lymphocytes with no epidermotropism. These cells also showed the expression of CD19, CD20, CD23 and CD5 antigens similar to those presented on PB lymphocytes. Polymerase chain reaction performed on bone marrow lymphocytes and a lesional skin biopsy using consensus primers for immunoglobulin heavy-chain genes also showed the same monoclonal population of B lymphocytes both in the bone marrow and in the skin. The patient received four courses of cladribine 0ú12 mg/kg**-1 daily as a 2-h infusion for five consecutive days. The courses were repeated at monthly intervals. The lymphocytosis gradually decreased and the PB count normalized after three courses. At the same time, a significant decrease in the cutaneous symptoms was observed. The patient became free of skin tumours after the fourth course of cladribine; only slight discoloration at the previous sites of cutaneous infiltration remained. There was no relapse of laukaemia cutis during a further 7 months of observation.


    972/2523

    Tytuł oryginału: Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes.
    Autorzy: Zapolska-Downar Danuta, Zapolski-Downar Andrzej, Naruszewicz Marek, Siennicka Aldona, Krasnodębska Barbara, Kołodziej Blanka
    Źródło: Life Sci. 2002: 71 (24) s.2897-2908, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 304,948

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: It is currently believed that oxidative stress and inflammation play a significant role in atherogenesis. Artichoke extract exhibits hypolipemic properties and contains numerous active substances with antioxidant properties in vitro. We have studied the influence of aqueous and ethanolic extracts from artichoke on intracellular oxidative stress stimulated by inflammatory mediators (TNFŕ and LPS) and ox-LDL in endothelial cells and monocytes. Oxidative stress which reflects the intracellular production of reactive oxygen species (ROS) was followed by measuring the oxidation of 2', 7'-dichlorofluorescin (DCFH) to 2', 7'-dichlorofluorescin (DCF). Agueous and ethanol extracts from artichoke were found to inhibit basal and stimulated ROS production in endothelial cells and monocytes in dose dependent manner. In endothelial cells, the ethanolic extraxt (50 ćg/ml) reduced ox-LDL-induced intracellular ROS production by 60 p.c. (p 0,001) while aqueous extract (50 ćg/ml) by 43 p.c. (p 0,01). The ethanolic extract (50 ćg/ml) reduced ox-LDL-induced intracellular ROS production in monocytes by 76 p.c. (p 0,01). Effective concentrations (25-100 ćg/ml) were well below the cytotoxic levels of the extracts which started at 1 mg/ml as assessed by LDH leakage and trypan blue exclusion. Penetration of some active substances into the cells was necessary for inhibition to take place as juged from the effect of preincubation time. These results demonstrate that artichoke extracts have marked protective properties against oxidative stress induced by inflammatory mediators ans ox-LDL in cultured endothelial cells and monocytes.


    973/2523

    Tytuł oryginału: Influence of contralateral stimulation by two-tone complexes, narrow-band and broad-band noise signals on the 2f1-f2 distortion product otoacoustic emission levels in humans.
    Autorzy: Lisowska Grażyna, Smurzyński Jacek, Morawski Krzysztof, Namysłowski Grzegorz, Probst Rudolf
    Źródło: Acta Otolaryngol. 2002: 122 (6) s.613-619, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 300,481

    Hasła klasyfikacyjne GBL:
  • pediatria
  • otorynolaryngologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In order to test the frequency specificity of the efferent suppressive effect on otoacoustic emissions, changes in the 2f1-f2 distortion product otoacoustic emission (DPOAE) levels induced by contralateral stimuli of different spectra were measured in 10 normally hearing adults. Three types of contralateral stimuli were used: (I) a set of 6 pairs of pure tones with the same frequencies as used for DPOAE stimulation; (II) 6 narrow-band noise signals with cut-off frequencies equal to the frequencies of the primary tones used for DPOAE stimulation; and (III) broad-band noise with a bandwidth of 840-6,000 Hz. A small suppressive effect was observed mainly in the mid-frequency region. Broad-band noise was more effective at suppressing DPOAEs than narrow-band noises and two-tone complexes. Occasionally, small enhancements in DPOAE amplitudes were observed. Based on the results of this study, it is concluded that DPOAE changes induced by contralateral stimuli are not frequency-specific, and are too small to have routine clinical value.


    974/2523

    Tytuł oryginału: Short-time deoxynivalenol treatment induces metabolic disturbances in the rat.
    Autorzy: Szkudelska Katarzyna, Szkudelski Tomasz, Nogowski Leszek
    Źródło: Toxicol. Lett. 2002: 136 (1) s.25-31, il., tab., bibliogr. [36] poz.
    Sygnatura GBL: 306,158

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Deoxynivalenol (DON) is produced by several Fusarium species and may contaminate feeds causing reduced food consumption and utilisation, reduced body weight gain and other unfavourable changes in animals. To verify if its adverse influence involves also hormonal and metabolic changes, the effect of DON on blood insulin, glucagon, leptin and metabolic parameters in growing Wistar rats was studied. Animals were treated subcutaneously with DON in the amount of 1 mg/kg b.w. After 3 days a significant increase in blood insulin, glucose and free fatty acids were observed in these animals in comparison to the control group. DON treatment caused an increment in glycogen depots and a reduction in triglycerides content in the muscle. Studies on isolated adipocytes revealed that DON (20 ćmol/l) slightly stimulated basal lipogenesis, whereas insulin-induced lipid synthesis and lipolysis were unchanged. Results obtained after subcutaneous DON administration indicate that its adverse effects in animals may partially result from metabolic disturbances evoked by this mycotoxin.


    975/2523

    Tytuł oryginału: Antimicrobial effect of Rhodiola rosea L. roots and callus extracts on some strains of Staphylococcus aureus.
    Tytuł polski: Wpływ wyciągów z korzeni i kalusa Rhodiola rosea L. na niektóre szczepy Staphylococcus aureus.
    Autorzy: Furmanowa M[irosława], Starościak B., Lutomski J., Kozłowski J., Urbańska N[atalia], Krajewska-Patan A., Pietrosiuk A[gnieszka], Szypuła W[ojciech]
    Źródło: Herba Pol. 2002: 48 (1) s.23-31, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie polskie: Wyciągi z korzeni Rhodiola rosea L. zebranych ze środowiska naturalnego (Babia Góra, Karpaty) oraz Ogrodu Roślin Leczniczych Instytutu Roślin i Przetworów Zielarkich w Poznaniu, jak również wyciągi z kalusa in vitro, zmniejszały wzrost trzech szczepów Staphylococcus aureus: ATCC 6538 P, ATCC 25923 i NCTC 4163. Najbardziej wrażliwy był S. aureus NCTC 4163. Wyciągi z korzeni były bardziej aktywne. Powodowały większą strefę zahamowania wzrostu.

    Streszczenie angielskie: Extracts of Rhodiola rosea obtained from intact plant roots harvested from the Medicinal Plants Garden of the Institute of Medicinal Plants in Poznań, from plants growing in the wild (Babia Góra in the Carpathian Mountains) and from callus cultivated in vitro reduced the growth of the three Staphylococcus aureus strains: ATCC 6538 P, ATCC 25923 and NCTC 4163. S. Aureus NCTC 4163 was the most sensitive to their action. The extracts of intact plant roots produced a higher growth inhibition zone than callus extracts.


    976/2523

    Tytuł oryginału: Application of supercritical CO2 extraction for separation of natural antibiotics from lichens.
    Tytuł polski: Zastosowanie ekstrakcji CO2 w stanie nadkrytycznym do rozdziału naturalnych antybiotyków z porostów.
    Autorzy: Lisickov K., Najdenova V., Zoltan D.
    Źródło: Herba Pol. 2002: 48 (1) s.32-39, il., tab., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: W badaniach użyto niekonwencjonalnej metody ekstrakcji do rozdziału aktywnego składnika (kwas usninowy) o właściwościach antybiotycznych z porostu Usnea barbata L. Ekstrakcję kwasu usninowego za pomocą CO2 w stanie nadkrytycznym z porostu Usnea barbata L. prowadzono w następujących warunkach: ciśnienie - 330 barów, czas ekstrakcji - 3 godz., temepratura - 40, 50, 60 i 80řC. Równocześnie dla porównania prowadzono klasyczną ekstrakcję za pomocą etanolu. Ponadto określono aktywność antybiotyczną kwasu usninowego otrzymanego za pomocą ekstrakcji CO2 w stanie nadkrytycznym wobec następujących drobnoustrojów: Staphylococcus aureus, Streptococcus pyogenes, Pneumococcus sp., Bacillus diphtheriae, Bacillus pumilus i Sarcina lutea.

    Streszczenie angielskie: In the frame of this materials in use non-conventional extraction treatment for separation of active component - (usnic acid), natural antibiotic from lichen Usnea barbata L. Extraction of usnic acid with supercritical CO2 from lichen Usnea barbata L., was leading under following conditions: working pressure 300 bars, time of extraction - 3h, workind temperature 40, 50, 60 and 80řC. In the same time is confirmed efficiency and superiority of supercritical extraction with CO2, against to classic solid-liquid extraxtion with ethanol. There was researching antibiotics activity of usnic acid obtains with supercritical extraction with CO2 over following microorganisms: Staphylococcus aureus, Streptococcus pyogenes, Pneumococcus sp., Bacillus diphtheriae, Bacillus pumils and Sarcina lutea.


    977/2523

    Tytuł oryginału: Longitudinal changes in mandibular bone mineral density compared with hip bone mineral density and quantitative ultrasound at calcaneus and hand phalanges.
    Autorzy: Drozdowska B., Pluskiewicz W.
    Źródło: Br. J. Radiol. 2002: 75 (897) s.743-747, tab., bibliogr. 13 poz.
    Sygnatura GBL: ,300,256

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The aim of this prospective study was to evaluate changes in bone mineral density (BMD) of the mandible (m-BMD) compared with hip BMD and ultrasound parameters of the calcaneus and hand phalanges over 28 months. The study group consisted of 18 post-menopausal edentulous women with no reasons known to effect bone metabolism, such as disease or medication. Each women had undergone natural menopause. No previous fractures were noted. Measurements were performed at baseline and repeated after 28 months. Bone status was assessed by measuring BMD using dual energy X-ray absorptiometry (DXA) at the mandible and hip and by measuring speed of sound (SOS), broadband ultrasound attenuation (BUA), stiffness index (SI) and amplitude-dependent SOS (Ad-SOS) using quantitative ultrasound at the calcaneus and phalanges of the hand. The coefficient of variation for mandibular measurements was 2,6 p.c. BMD of the mandible, femoral neck and Ward's triangle decreased significantly (-7.54 p.c., -1.2 p.c., -1.97 p.c. per year, respectively, p 0.05), whilst BUA, SI and Ad-SOS decreased, but not significantly (-1.1 p.c., -0.47 p.c., -0.08 p.c. per year, respectively). Both SOS and BMD of the trochanter had almost the same value without significant differences. The least significant change (LSC), denoting the minimum difference between two successive results in an individual that can be considered to reflect a real change,was calculated. With the exception of changes in m-BMD, no significant changes were observed at any of the sites for the majority of the women (38-39 p.c.)...


    978/2523

    Tytuł oryginału: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the placenta and myometrium.
    Autorzy: Kuczyński Jarosław, Uszyński Waldemar, Żekanowska Ewa, Soszka Tomasz, Uszyński Mieczysław
    Źródło: Eur. J. Obstet. Gynecol. 2002: 105 (1) s.15-19, il., bibliogr. 17 poz.
    Sygnatura GBL: 305,582

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • ciąża
  • płeć żeńska

    Streszczenie angielskie: Background: Placental abruption is mainly due to the rupture of the uterine spiral arteries, but adjacent tissues are also damaged and substances derived from distintegrated placenta and myometrium probably cause coagulation disturbances, such as hypofibrinogenemia and disseminated intravascular coagulation (DIC). Aim: To measure whether placenta and myometrium are significant sources of tissue factor (TF) and tissue pathway inhibitor (TFPI), the components of key role in the initiation of coagulation. Materials and methods: Strips of placenta and myometrium were obtained from 48 women delivered by cesarean section at term. TF and TFPI concentrations were measured by immunoenzymatic method (ELISA) in tissue homogenates. Main results: Concentration of TF in placenta and myometrium was 31 (25-37) and 7.4 (4.9 - 11.4) ng/mg of total protein, respectively. In the plasma of the same women, it was 0.004 ng/mg of total protein. TFPI concentration was 13 (10 - 17) ng/mg of total protein in placenta, 4.5 (3.1 - 7.3) ng/mg in myometrium, and 0.70 (0.50 - 0.80) ng/mg in blood plasma protein. Conclusion: The levels of TF in placenta and myometrium, over TF in blood plasma may be clinically significant in obstetrics, for instance, in the etiology of DIC in placental abruption. The concentration of TFPI - natural inhibitor of TF - seems to be too low to prevent initiation of coagulation.


    979/2523

    Tytuł oryginału: Detection of serum Pneumocystis carinii DNA in the course of P. carinii pneumonia in experimental animals and HIV-infected patients.
    Autorzy: Gołąb Elżbieta, Sobolewska Alicja, Bitkowska Elżbieta, Bednarska Agnieszka, Berak Hanna, Dzbeński Tadeusz H.
    Źródło: Acta Parasitol. 2002: 47 (3) s.235-238, tab., bibliogr. [9] poz.
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • aIDS
  • genetyka
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: A nested PCR which amplified a part of the mitochondrial gene encoding the large subunit of rRNA of Pneumocystis carinii was used to detect P. carinii DNA in sera obtained from HIV-infected patients and immunosuppressed rats. P. carinii DNA was found in sera from nearly 52 p.c. of rats between 6th and 9th week of immunosuppressive treatment and in 12 serum samples out of 51 collected from HIV-infected patients, including 4 from clinically suspected and laboratory confirmed cases of PCP. The results of the studies indicated that DNA of P. carinii is most likely to appear in the blood in the advanced infection, however, the test for serum DNA may be of little value for the diagnosis of PCP since negative results do not exlude active infections and positive ones may be encountered in asymptomatic carriers.


    980/2523

    Tytuł oryginału: Pathogenesis of experimental toxoplasmosis in mice with strains differing in virulence.
    Autorzy: Kodym Petr, Blażek Karel, Maly Marek, Hrda Stepanka
    Źródło: Acta Parasitol. 2002: 47 (3) s.239-248, il., tab., bibliogr. s. 247-248
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: Parameters of virulence and the course of infection were compared in mice infected with Toxoplasma gondii strains P-Cz (mice virulent), 38 (cyst-forming, highly pathogenic) and HIF (cyst-forming, virulent). Mice, that succumbed to infection with cyst-forming strain 38 had lesions in the spleen (days 7-14 p.i.), liver (days 7-14 p.i.), lungs (days 9-21 p.i.), heart (days 14-21 p.i.), and brain (days 21-35 p.i.). In contrast, the animals which succumbed to strain P-Cz had practically unaffected hearts and brains. There were no fundamental differences in the temporal sequence of histopathological changes in infection with virulent and both cyst-forming strains. Depending on the virulence of each strain the infections differed markedly in the degree of organ damage, duration of parasitemia, numbers of cysts in the brain , as well as in mortality and body weight loss. The differencesin post mortem findings are not due to different organ affinity, but to the virulence-dependent time of death. All P-Cc infected mice die in the early stage of infection, before their hearts and brains can be seriously damaged.


    981/2523

    Tytuł oryginału: Larval toxocarosis in mice: immunoreactivity after multiple high dose infections.
    Autorzy: Aldawek Ahmed M., Levkut Mikulas, Revajowa Viera, Dvoroznakova Emilia
    Źródło: Acta Parasitol. 2002: 47 (3) s.249-254, il., bibliogr. [24] poz.
    Sygnatura GBL: 303,018

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Immunological responses of mice to threefold infection with infective Toxocara canis were studied up to 42 days. Mice of the experimental group were infected orally with 1000 infective eggs on days 0, 12, and 20 of the experiment (a total of 3000 eggs/mouse). The proliferative activity of spleen lymphocytes, production of specific antibodies in the serum, leukocyte counts, and T cells subpopulations in the blood and spleens were examined. The spleen T cells were significantly inhibited to 21 day post infection (dpi) while B cells were stimulated. An increased. An increased level of specific antibodies persisted almost the whole experiment. Leukocytosis with a dominant lymphocytosis was evident. In the peripheral blood the number of both CD8+ and CD4+ cells was significantly increased. Contradictory, a significant increase of the spleen CD8+ cells with a significant decrease of CD4+ cells was observed. In conclusion, the multiple high infection resulted in variable changes in the immune effector mechanisms. Some components were stimulated while others were inhibited which may suggest that immunosuppression is not the only major outcome of larval toxocarosis.


    982/2523

    Tytuł oryginału: Allergen-specific T lymphocytes as targets for specific immunotherapy: striking at the roots of type I allergy.
    Autorzy: Bohle Barbara
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.233-241, bibliogr. 80 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the past decades allergic diseases have tremendously increased and hypersensitivity reaction represent a growing healt concern in industrialized countries. Despite various effective therapeutic options for the treatment of allergic disease, only specific immunotherapy (SIT) has been shown to have effects on the underlying immunological mechanisms, namely functional changes at the level of T helper (Th) lymphocytes. It was found that allergen-specific CD4+ Th2 lymphocytes play a key in the pathophysiology of atopic disease. During successful SIT, the Th2-dominated immune response is modified towards a Th1 response, leading to a decline in allergen-specific IgE levels in the long term. In order to improve the efficacy and safety of SIT, novel approaches were developed targeting allergen-specific Th2 lymphocytes since specific inactivation or modulation towards Th1 cells could interfere with the disease process. In view of this aspect, this review will basically focus on two new, promising approaches to improve SIT: (1) the use of hypoallergenic proteins characterized by reduced IgE-binding capacities but retained T lymphocyte-activiting properties and (2) oligodeoxynucleotides containing CpG motifs as an example of adjuvants which foster Th1 immune responses. Both approaches promise to be capable of adjusting the pathological Th2 immune response.


    983/2523

    Tytuł oryginału: Type I interferons as immunoregulatory molecules; implications for therapy in experimental autoimmune uveoretinitis.
    Autorzy: Mizuguchi Junichiro, Takeuchi Masaru, Usui Masahiko
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.243-254, bibliogr. 125 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: Clinical trials have shown that type I interferon (IFN)-ŕ/á have some beneficial effects on organ-specific autoimmune diseases, such as Behcet's diseases and multiple sclerosis, although the precise mechanisms remain largely unresolved. T helper cells 1(Th1)-mediated autoimmune responses are involved in the initiation and/or progression of human uveitis, such as Behcet's disease. The animal model of experimental autoimmune uveoretinitis (EAU), characterized by a monophasic clinical course, has contributed to the understanding of the pathogenesis of human uveitis. Th1 producing IFN-ç induce EAU development, while Th2 producing IL-4/IL-10 prevent the disease. However, depending on the cytokine milieu, the pro-inflammatory cytokine IFN-ç may attenuate the autoimmune responses and anti-inflammatory cytokine IL-4 exacerbates it. Chemokines also play a crucial role in EAU development, which might be resolved by Th2-mediated immune responses. The administration of IFN-ŕ/á prevents EAU development, accompanied by a diminished production of IFN-ç/IL-10. Interestingly, however, IFN-ŕ/á also have some beneficial effects on patients with Th2-like phenotype in addition to Th1-like phenotype. Thus, the immuno-modulatory action of IFN-ŕ/á may be dependent on the context of cytokine combinant and/or their concentrations.


    984/2523

    Tytuł oryginału: V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?
    Autorzy: Golub Rachel
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.255-262, il., bibliogr. 60 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Lymphocytes can undergo novel types of secondary genetic rearrangements that after the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.


    985/2523

    Tytuł oryginału: The TCR/CD3 complex: molecular interactions in a changing structure.
    Autorzy: Feito Maria Jos‚, Jim‚nez-Perianez Arturo, Ojeda Gloria, Sanchez Alejandra, Portol‚s Pilar, Rojo Jos‚ M.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.263-272, il., bibliogr. 94 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement, 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.


    986/2523

    Tytuł oryginału: DNA viruses and genetic modification of dendritic cells.
    Autorzy: Jenne Lars, Steinkasserer Alexander
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.273-277, bibliogr. 34 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • mikrobiologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: An alternative approach to the use of tumor-peptide-loaded dendritic cells (DC) in immunotherapy would be the use of genetically modified DC using viral vectors expressing tumor-associated antigens (TAA). However, viruses have developed several immune escape mechanisms and, thus, one has to study the interaction between viruses and DC beforer these viruses can be used as an alternative strategy. Here we report that vaccinia virus (VV) as well as herpes simplex virus 1 (HSV-1) are able to potently infect monocyte-derived DC, however, this infection leads to the inhibition of the DC-mediated T cell stimulation in vitro.


    987/2523

    Tytuł oryginału: The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders.
    Autorzy: Holtmann Martin H., Schuchmann Marcus, Zeller Geraldine, Galle Peter R., Neurath Markus F.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.270-288, il., bibliogr. 95 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Tumor necrosis factor ŕ (TNF-ŕ) is a pleiotropic cytokine with strong proinflammatory and immunomodulatory properties. TNF-ŕ plays a critical role in many acute or chronic inflammatory diseases and anti-TNF strategies have proven to be clinically effective. Two TNF-specific cell surface receptors. TNF-R1 (p60) and TNF-R2 (p80), have been identified and the function of these receptors and the downstream intracellular signal-transduction pathways have been extensively studied in vitro. For a long time p60 was considered to be the predominant mediator of TNF signaling, whereas p80 was ascribed only an auxilliary function. However, there is increasing clinical and experimental evidence for an important independent role of p80 signaling in chronic inflammatory conditions. To date, most data exist for Crohn's disease. Upregulation of p80 and increased p80 signaling aggravates experimental colitis and is likely to contribute to the chronicity of inflammation in vivo. Further studies are required to elucidate critically important steps in TNF signaling that might be dysregulated. This will lead to a better understanding of the pathogenesis of these diseases and potentially reveal new, more specific therapeutic targets.


    988/2523

    Tytuł oryginału: The cGMP syntheisis and PKG1 expression in murine lymphoid organs.
    Autorzy: Kurowska Ewa, Kobiałka Marcin, Zioło Ewa, Strządała Leon, Gorczyca Wojciech A.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.289-294, il., bibliogr. 35 poz.
    Sygnatura GBL: 304,223

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Numerous reports indicate that cyclic 3', 5' guanosine monophosphate (cGMP) is involved in the regulation of immune processes. However, the mechanisms responsible for the synthesis of this nucleotide and its signaling pathways in immune cells are still not well recognized. The aim of our studies was to establish: 1) which form of guanylyl cyclase (GC) synthesizes cGMP in murine lymphoid organs and 2) whether the same organs express the isoforms PKG1ŕ and/or PKG1á of protein kinase G, known as possible target for synthesized cGMP. Cells isolated from thymus, lymph nodes, and spleen were treated with activators (SNP, ANP, CNP, STa) of soluble or particulate cyclases. Sodium nitroprusside (SNP) elevated intracellular cGMP 2-fold in thymic and lymph node cells and about 10-fold in spleen cells. Atrial natriuretic peptide (ANP) caused modest but statistically significant increases of cGMP in cells of all three organs. Additionally, spleen cells elevated their cGMP content about 2-fold in response to C-type natriuretic protein (CNP). In cellular homogenates of the all analyzed organs, the antibody anti-PKG1á stained the 78 kDa band corresponding to the molecular mass PKG1. Only homogenates of spleen cells were stained by the antibody recognizing PKG1ŕ. Our results indicate that in the investigated organs cGMP may be synthesized mainly by soluble GC in response to nitric oxide. The modest increase of cGMP upon stimulation by ANP suggests that in all these organs either exists only a small subpopulation of cells that express particulate cyclase GC-A or GC-A is expressed at very low level...


    989/2523

    Tytuł oryginału: Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner.
    Autorzy: Basta-Kaim A., Budziszewska B., Jaworska-Feil L., Tetich M., Leśkiewicz M., Kubera M., Lasoń W.
    Źródło: Neuropharmacology 2002: 43 (6) s.1035-1043, il., bibliogr. [36] poz.
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Antipsychotic drugs can modulate transcription factors ansd also nuclear receptors, but their action on glucocorticoid receptors (GR)-members of the steroid/thyroid hormone receptor family has been studied so far. In the present study we investigated effects of various antipsychotics on the glucocorticol-mediated gene transcription in fibroplast cells, stably tranfected with a mouse mammary tumor virus promoter (LMCAT cells). Chlorpromazine (3-100 ćM) inhibited the corticosterone-induced gene transcription in a concentration- and time-dependent manner. Clozapine showed a similar, but less potent effect, while haloperiod acted only in high concentrations, and other antipsychotics drugs (sulpiride, raclopride, remoxipride) were without any effect. It was also found that a phorbol ester (an activator of protein kinase C (PKC) and A-23187 (Ca2+-ionophore) attenuated the inhibitory effect of chloropromazine on the GR-induced gene transcription. An antagonist of the L-type Ca2+ channel, as an inhibitor of phospholipase C (PLC) inhibited the corticosterone-induced gene transcription, but had no effect on the chlorpromazine-induced changes. The involvement of a PKC/LC pathway in the chlorpromazine action was confirmed by Western blot analysis showed that the drug in question decreased the PLC-á1 protein level, and to a lesser extent that of the PKC-ŕ protein in LMCAT cells. The aferomentioned data suggest that inhibition of the glucorticosteroid-induced gene transcription by chlorpromazine and clozapine may be a mechanism by which these drugs block some effects induced...


    990/2523

    Tytuł oryginału: Biocompatibility of C-C composites covered with PyC and pHEMA.
    Autorzy: Buresova M., Balik K., Machovic V., Novotna M., Pesakova V., Hulejova H., Sochor M.
    Źródło: Inż. Biomater. 2002: 5 (20) s.3-5, il., tab., bibliogr. 3 poz.
    Sygnatura GBL: 313,500

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny


    991/2523

    Tytuł oryginału: Keratinolytic fungi in an acidic petroleum waste lagoon at a petroleum refinery.
    Tytuł polski: Grzyby keratynolityczne w lagunie kwaśnych odpadów rafineryjnych na terenie rafinerii ropy naftowej.
    Autorzy: Ulfig Krzysztof, Płaza Grażyna, Terakowski Maciej, Worsztynowicz Adam
    Źródło: Rocz. Państ. Zakł. Hig. 2002: 53 (3) s.267-276, tab., bibliogr. 21 poz., sum.
    Sygnatura GBL: 301,906

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy było przebadanie grzybów keratynolitycznych w lagunie kwaśnych odpadów rafineryjnych (przed bioremediacją) w obrębie rafinerii ropy naftowej znajdującej się na terenie gęsto zaludnionym. Wysiokie stężenia węglowodorów ropopochodnych (nie polarnych i polarnych związków alifatycznych oraz WWA) uniemożliwiły wzrost badanych grzbów w glinie i odpadach z laguny. Natruralny proces samooczyszczania znacznie obniżył zawartość węglowodorów, podwyższył pH i spowodował obfity wzrost Trichophyton ajelloi w glebie organicznej. Gleba ta zawierała materiał pochodzący ze strefy korzeniowej traw rosnących w kilku zielonych oazach na obrzeżu laguny. Nie można wykluczyć, że szczepy Trichophyton ajelloi zaadaptowane do skrajnych warunków w lagunie brały aktywny udział w procesie usuwania zanieczyszczeń ropopochodnych. Gatunki grzybów wyizolowane w niniejszej pracy nie stwarzaly istotnego zagrożenia epidemiologicznego. Zanieczyszczenia ropopochodne mogą jednak sprzyjać wzrostowi potencjalnych patogenów, np. Microsporum gypseum w innych typach gleb.


    992/2523

    Tytuł oryginału: Adhesion molecules of immunoglobulin gene superfamily in stroke.
    Autorzy: Zaremba Jarosław, Losy Jacek
    Źródło: Folia Morphol. 2002: 61 (1) s.1-6, bibliogr. 60 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Stroke-induced inflammatory reaction leads to the accumulation of leukocytes in the brain ischaemic region, where they exert a detrimental effect - promotion and extension of cerebral damage. Intracerebral infiltration of peripheral blood leukocytes requires prior endothelial-leukocyte interactions that are mediated by such cell surface proteins as adhesion molecules. Among adhesion molecules, it is the immunoglobulin gene superfamily (IgSF) that is responsible for strong attachment and transendothelial migration of leukocytes. The principal members of IgSF are: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1). In this review the following issues were described and discussed: an increased expression of ICAM-1 and VCAM_1 in ischaemic brain as well as a detection of their soluble(s) forms in sera of stroke victims. The presented data suggest the involvement of both ICAM-1 and VCAM-1 in the sequence and timing of the infiltration of leukocytes into the brain ischaemic zone after stroke. They have also revealed changes in serum concentrations of sICAM-1 and sVCAM-1 that are characteristic for stroke. Recently, increase in sPECAM-1 levels in serum and cerebbrospinal fluid (CSF) has been shown within 24 h of the onset of stroke, having indirectly suggested involvement of the molecule in the inflammatory events during the early phase of stroke.


    993/2523

    Tytuł oryginału: Cholinergic innervation and calretinin-immunoreactive neurones in the hippocampus during postnatal development of the rat brain.
    Autorzy: Ludkiewicz Beata, Wójcik Sławomir, Spodnik Edyta, Domaradzka-Pytel Beata, Moryś Janusz
    Źródło: Folia Morphol. 2002: 61 (1) s.7-14, il., bibliogr. 41 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Immunohistochemical study of the cholinergic innervation of the hippocampal calretinin-containing cells was conducted on 28 rat brains of postnatal ages: PO, P4, P7, P14, P21, P30 and P60. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and calretinin were analysed using confocal laser-scanning microscope. Obtained data demonstrate that during development as well as in adult species calretinin-containing neurones in teh rat hippocampus form sparse synaptic contact with VAChT-ir terminals. It seems probable that cholinergic innervation is not crucial for the functioning of CR-ir cells - probably they remain under the greater influence of a system other than the cholinergic system.


    994/2523

    Tytuł oryginału: Uterus-innervating neurones of paracervical ganglion in the pig: immunochistochemical characteristics.
    Autorzy: Wąsowicz Krzysztof, Podlasz Piotr, Czaja Krzysztof, Łakomy Mirosław
    Źródło: Folia Morphol. 2002: 61 (1) s.15-20, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • weterynaria

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie angielskie: Immunohistochemical characteristics of neurones innervating the porcine uterus located in paracervical ganglia were studied with a combination of retrograde fluorescent tracing and immunofluorescence. Retrograde fluorescent tracer Fast Blue (FB) was injected into the uterine horn and uterine cervix. The presence of biologically active substances, tyrosine hydroxylase (TH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), galanin (GAL), Met-enkephalin-Arg-Gly-Leu (MEAGL) and calcitonin gene-related peptide (CGRP) was studied in FB-positive neurones localised in paracervical ganglia. FB-positive neurones containing TH, NPY, VIP and MEAGL were numerous, while those containing CGRP were scare. The results pointed to some species-related differences in immunochistochemical coding of neurones of paracervical ganglion responsible for uterus innervation.


    995/2523

    Tytuł oryginału: The morphological types of neurones of the medial and lateral mamillary nuclei in a newborn guinea pig: Nissl, Klver-Barrera and Golgi studies.
    Autorzy: Robak Anna
    Źródło: Folia Morphol. 2002: 61 (1) s.21-30, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie

    Streszczenie angielskie: The studies were carried out on the hypothalamus of 5 newborn (PO stage) guinea pigs. The sections were impregnated according to three modifications of the Golgi technique or stained according to the Nissl and Klver-Barrera methods. On the basis of the shape and size of perikarya, dendroarchitecture, patern of axon as well as the inner structure of neurones, in the medial (Mm) and lateral (MI) mamillary nuclei for morphological types of nerve cells were distinguished: cap-like with two subtypes (33 p.c. of the cell population), fusiform (35 p.c.), triangular (12 p.c.) and rounded unidendritic (21 p.c.) neurones. The majority of them possessed spines on their dendrites. They spiny cells, both cap-like and fusiform ones, were observed preponderantly, in the medial mamillary nucleus, whereas in the lateral mamillary nucleus there were mainly seen the triangular and fusiform neurones, either spiny or aspiny cells. The spineless rounded unidendritic cells were dispersed throughout the mamllary region, but the were twice as numerous in Mm as in MI, where they were the least numerous.


    996/2523

    Tytuł oryginału: Development of valves in the small saphenous vein in human fetuses.
    Autorzy: Czarniawska-Grzesińska Małgorzata, Bruska Małgorzata
    Źródło: Folia Morphol. 2002: 61 (1) s.37-42, il., bibliogr. 15 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The study was performed on 82 small saphenous veins in human fetuses of both sexes aged 9 to 37 weeks. The earliest valves were observed in 13 week-old fetuses. In fetuses between 13 and 18 weeks old the number of valves increased from 1 to 8. In the older fetuses between 19 and 37 weeks the number of valves varied from 5 to 9 and does not seem to be relsated to age. During development more valves were found in the upper part of the small saphenous vein. The height of valves increases with age and differs between particular valves of the same vein.


    997/2523

    Tytuł oryginału: Multiple vessel variations in the retropubic region.
    Autorzy: Sarikcioglu Levent, Sindel Muzaffer
    Źródło: Folia Morphol. 2002: 61 (1) s.43-45, il., bibliogr. 9 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We encountered some multiple vessel variationsin the retropubic region of a 55-year-old male cadaver. The obturator artery had its origin from the external iliac artery, and inferior epigastric artery from the femoral artery. Additionally, an anastomosis between obturator and inferior epigastric veins (venous Crown of death) was observed.


    998/2523

    Tytuł oryginału: Bilio-pancreatic anomalies obscured with MRCP.
    Autorzy: Bobek-Billewicz Barbara, Gorycki Tomasz, Studniarek Michał, Szurowska Edyta
    Źródło: Folia Morphol. 2002: 61 (1) s.47-51, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • radiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In this article the authors discuss whether or not diagnostic potential of MR cholangiopancreatography is strong enough to replace direct cholangiography in all cases. The pre- surgery analysis of a variety of pancreato-biliary disorders diagnosed using MRCP images is presented with the emphasising the importance of source images. Six cases of pancreato-biliary disorders are presented in which MRCP indicated the place of ductal stenosis as well as the morphologic variants or ductal uninspected shape which is critical for surgery or planned drainage. Coronal and axial MRCP source and MIP images were obtained with 0,5T Gyroscan NT. Anomalies of the biliary or pancreatic ducts included two cases of choledochal cystic dilatation; two cases of aberrant biliary ducts, one case of gallbladder duct variant and a case of an additional pancreatic duct. In 3 out of 6 cases, the MRCP source images produced using the complementary method supplied more complete information concerning ductal junctions than teh MIP images. Whereas in 3 out of 6 cases, both kinds of images were equally reliable. In 4 out of 6 cases, endoscopy was performed, an din 2 cases ERCP images were not diagnostic for ductal anatomy. However, full delineation of biliary and pancreatic ducts was complete in all MRCP images. MRCP within source images and maximum intensity projections show particular promise for the assessment of pancreatobiliary anomalies in order to reduce the number of higher-risk endoscopic interventions. The technique should be the method ...


    999/2523

    Tytuł oryginału: Aberrant left subclavian artery.
    Autorzy: Jakubowicz Marian, Ratajczak Wojciech, Nowik Marek
    Źródło: Folia Morphol. 2002: 61 (1) s.53-56, il., bibliogr. 20 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This paper describes a rare case in which the left subclavian artery originates from a common stem arising from the aortic arch and splits into a brachiocephalic trunk and a left subclavian artery. The course of other large vessels of the aortic arch in this case are typical.


    1000/2523

    Tytuł oryginału: Neurological symptoms as the result of enlarged dimensions and non-typical course of inferior superficial temporal vein.
    Autorzy: Maciejewski Ryszard, Drop Andrzej
    Źródło: Folia Morphol. 2002: 61 (1) s.57-60, il., bibliogr. 20 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Neurological symptoms as the result of non-typical course of superficial cerebral veins are described in available literature very rarely. The case described below indicates that in some circumstances the compression symptoms derived from the cerebral cortex may be incredibly more serious than their anatomical reasons. In our observation a young woman was described complaining of paroxysmal numbness of the left upper limb with paraesthesiae of the left side of the face, the left eye and left half of the tongue. The patient said that in childhood she used to have paroxysmal itching of the left hand. She also said that CT of the head made a few years ago after a car accident was without pathological changes. Neurological examination, x-ray of the skull and EEG test performed during first visit proved normal. After one year of the disease, Jackson-type epilepsy, combined with loss of sensation of the left half of the face for the firszt time, was present. Neurological andx ophthalmological examination of the bottom of the eye proved normal. Skull x-ray was normal. Then disturbances of the vision in the left half of the field appeared. EEG was still in norm. The MRI the showed the asymmetry in the course and dilated superficial vein between teh basis of the right temporal lobe and the tentorium of the cerebellum. The diameter of this vein was 2.5 mm, but there were no vascular malformations. Bottom of the eye normal, but in the field of vision the white and red colours were dominated.


    1001/2523

    Tytuł oryginału: Professor Władysław Kubik (1923-2000).
    Autorzy: Narkiewicz Olgierd, Grzybiak Marek
    Źródło: Folia Morphol. 2002: 61 (1) s.61-62, il.
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Kubik
  • Władysław 1923-2000


    1002/2523

    Tytuł oryginału: Visualisation of diverticula of the upper part of the alimentary tract; comparison of roentgenologic and endoscopic techniques.
    Autorzy: Burdan Franciszek, Różyło-Kalinowska Ingrid, Juśkiewicz Wit, Maciejewski Ryszard, Wallner Grzegorz, Zgodziński Witold, Zinkiewicz Krzysztof, Złomaniec Janusz, Dąbrowski Andrzej
    Źródło: Folia Morphol. 2002: 61 (1) s.297-301, il., bibliogr. 37 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • radiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Diverticula of the upper part of the alimentary tract, irrespcetive of their etiology, are frequently observed benign changes of the pharynx, oesophagus, stomach and duodenum. In the present work, patients of the II General Surgery Department of the Medical University of Lublin, with radiologiaclly or endoscopically proved diverticula of the upper part of the alimentary tract, were examined. The presence of diverticula of such localalisation was an indication for supplementary endoscopic or radiological examination. The localisation, size, diameter of the opening, mucosal relief of diverticula and its contiguity were checked and analysed. Our data suggest that both medical procedures are complementary to each other. All previously observed changes in diverticula of the thoracic part of the oesophagus and the infradiaphgram part of the alimentary tract were fully proved. The radiological examination gave a better view of Zenker's diverticulum, especially in short and obese patients. Sampling and better visualisation of the diverticula opening testify to the unquestionable superiority of endosopy. However, precise evaluation by radiological process fully completes the diagnostic protocol. Both diagnostic procedures are usually supplemented by manometric examination of the oesophagus and superior and inferior oesophageal sphincters. This enables teh accurate diverticulaetiology to be stated.


    1003/2523

    Tytuł oryginału: Professor Stanisław Misztal, (1927 - 2002).
    Autorzy: Przegaliński Edmund
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.211-213, il.
    Sygnatura GBL: 313,156

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Misztal
  • Stanisław 1927-2002


    1004/2523

    Tytuł oryginału: Beneficial and harmful effects of thiols.
    Autorzy: Włodek Lidia
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.215-223, il., bibliogr. 47 poz.
    Sygnatura GBL: 313,156

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Biothiols are extraordinarily efficient antioxidants protecting the cells against conseuences of damage induced by free radical, due to their ability to react with the latter. In such antioxidant reactions, thiols undergo oneelectron oxidation with the formation of thiyl radicals. For this reason, attention has been focused mostly on antioxidant properties of thiols. Considerably less attention has been paid to thiyl radicals (RS) formed simultaneously in these reactions. However, protective and repairing efficacy of thiols depends not only on their capacity to detoxify free radicals but also on chemical character and reactivity of the formed thiyl radical. Furthermore, quick and efficient removal of RS radical leads to disturbance in balanced state of antioxidant reaction, which effectively increases repairing capacity. Dangerous thiyl radicals, which can cause peroxidative injury, should immediately undergo regenerative reduction to thiols. Under physiological conditions, thiyl radicals can react with thiolate anion yielding disulfide radical anion (RSSR) as an intermediate and finally disulfides and superoxide radical anion (O2), which is next inactivated in teh reaction catalyzed by superoxide dismutase (SOD). Thiyl radicals can also be reduced to thiols by reacting with ascorbate with the formation of low-activity ascorbyl radical, that subsequently enters disproportiation reaction.


    1005/2523

    Tytuł oryginału: Neurotransmitter levels and [3H]muscimol binding sites in the brain of rats selectively bred for alcohol preference and non-preference.
    Autorzy: Dyr Wanda, Siemiątkowski Marek, Krząścik Paweł, Bidziński Andrzej, Płaźnik Adam, Kostowski Wojciech
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.225-230, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Alcohol-naive high- (Warsaw High Preferring; WHP) and low- (Warsaw Low Preferring; WLP) preferring lines of rat were studied to determine the distribution and density of [3H]muscimol binding sites in the brain using quantitative autoradiography. The results have shown no difference in the density of [3H]muscimol binding sites in the cingulate and frontal cortex, dorsal and ventral striatum, lateral and medial septum, caduate-putamen, nucleus accumbens in the both lines of animals. In the separate experiments, the levels of neurotransmitters were measured in the frontal cortex, hippocampus and striatum of the WHP and WLP rats. The content of dopamine was significantly lower in the striatum of the WHP rats as compared to the WLP animals. The levels of serotonin and noradrenaline were without any important differences in the examined structures of both lines of rats.


    1006/2523

    Tytuł oryginału: Effects of ŕ-ketoglutarate on lipid peroxidation and antioxidant status during chronic ethanol administration in Wistar rats.
    Autorzy: Velvizhi Selvaraj, Nagalashmi Thiyagarajan, Essa Mustafa Mohamed, Dakshayani Kadiyala Babu, Subramanian Perumal
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.231-236, tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The effects of ŕ-ketoglutarate (ŕ-KG) on ethanol-induced hepatotoxicity were studied in biochemiacal experiments in rats. The levels of serum transaminases and thiobarbituric acid reactive substances were significantly increased in ethanol-treated rats. These levels were significantly decreased in ŕ-KG- and ethanol-treated rats. Further, non-enzymatic (vitamins C and E) and enzymatic (superoxide dismutase and catalase) antioxidants were significantly decreased in ethanol-treated rats, and were increased in ŕ-KG- and ethanol-treated rats. The biochemical alterations during ŕ-KG treatment could be due to (i) teh participation of ŕ-KG in the non-enzymatic oxidative decarboxylation in the hydrogen peroxide decomposition process and (ii) enhancing the proper metabolism of fats which could suppress oxygen radical generation and thus prevent the lipid peroxidative damages in rats.


    1007/2523

    Tytuł oryginału: Influence of SKF 91488, histamine n-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats.
    Autorzy: Jochem Jerzy, Żwirska-Korczala Krystyna, Rybus-Kalinowska Barbara, Jagodzińska Julia, Korzonek-Szlacheta Ilona
    Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.237-244, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The histamine system influences various activities of the central nervous system, including cardiovascular regulation. Histamine administered intracerebroventricularly (icv) in anesthetized rats produces the increase in mean arterial pressure (MAP) and xdheart rate (HR), however, in contrast to normotensive animals, histamine-induced rises in MAP an dHR in critically hypotensive animals are significantly higher. Similarly to exogenous histamine, inhibition of the central histamine N-methyltransfer (HNMT) activity (the enzyme catabolizing histamine in the central nervous system) resulting in the increase in endogenous histamine concentration, also leads to the pressor effect in normotensive rats. The present study was designed to determine the role of endogenous centarl histamine in cardiovascular regulation in a rat model of blood volume-blood pressure controlled hemorrhagic hypotension. In normotensive animals, HNMT inhibitor SKF 91488 produced dose-dependent (20-100 ćg icv) pressor effect accompanied by tachycardia, similarly as exogenous histamine (0.5-5 ćg icv) did. The subpressor dose of SKF 91488 (10 ćg) evoked the increased in blood volumes necessary to induce hypotension of 40 and 20 mmHg and the action was accompanied by the rise in histamine concentrations in the hypothalamus (5.18 ń 0.45 vs 4.23 ń 0.41 nmol/g; p 0.5) and medulla oblongata (0.41 ń 0.05 vs 0.30 ń 0.06 nmol/g; p 0.05), with no changes in the cortical histamine concentrations (0.84 ń 0.18 vs 0.75 ń 0.17 nmol/g), compared to the conrol icv saline-treated group...


    1008/2523

    Tytuł oryginału: The effect of poneratoxin on neuromuscular transmission in the rat diaphragm.
    Autorzy: Hendrich Andrzej B., Mozrzymas Jerzy W., Konopińska Danuta, Scuka Maria
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.195-202, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The effect of the ant venom neuropeptide - poneratoxin (PoTX) - on neuromuscular transmission in rat diaphragm tissue was studied by means of intracellular recordings of spontaneous miniature endoplate potentials (MEPPs)and of nerve evoked endplate potentials (EPPs). A 2 ćM concentration of PoTX caused a pronounced but transient increase in MEPPs frequency. Moreover, within the first few minutes of PoTX administration, the area, rise time and half decay time of MEPPs gradually decreased, reaching steady values after 15-20 min. The alteration of the area, rise time and half decay time of EPPs after PoTX application was similar to that observed for MEPPs. We conclude that PoTX affects neuromuscular transmission in rat tissue, and suggest that PoTX could exert both pre- and postsynaptic effects.


    1009/2523

    Tytuł oryginału: W. Mejbaum - Katzenellenbogen's Molecular Biology Seminars. 9. Liposomes. From models to applications: abstracts.
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.213-305, il., tab., bibliogr. [przy streszcz.] - Seminarium pt. Liposomy od modeli do zastosowań Wrocław - Szklarska Poręba - Piechowice 26-29.05. 2002
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    1010/2523

    Tytuł oryginału: Hip biomechanics in orthopaedic clinical practice.
    Autorzy: Antolic Vane, Kralj-Iglic Veronika, Iglic Ales, Pompe Borut
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.311-315, il., tab., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Mantuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Radiographic and clinical studies, cupled with biomechanical assessment of the hip, are important tools for predicting the development of hip osteoarthitis of the hip. In order to better understand the treatment of hip dysplasia, it is necessary to determine the contact stress in the hip joint. In this study, a three-dimensional mathematical model was used to determine hip joint contact stress. Because of the discrepancy in the results of analyses of different radiographic indicators of hip dysplasia, the calculation of hip joint contact stress is proposed for a more accurate assessment of the severity of hip dysplasia.


    1011/2523

    Tytuł oryginału: Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.
    Autorzy: Benoit Evelyne, Mattei Cesar, Ouanounou Gilles, Meunier Frederica A., Suput Dusan, Le Gall Frederic, Marquais Michel, Dechraoui Marie Y., Molgo Jordi
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.317-321, bibliogr. 15 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Żaby

    Streszczenie angielskie: This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cationselective pores and indirectly affect the functioning of the Na+-Ca++ exchanger.


    1012/2523

    Tytuł oryginału: Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes.
    Autorzy: Kovacic-Milivojevic Branka, Damsky Caroline C., Gardner David G., Ilić Dusko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.323-329, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: The vertebrate heart responds to hemodynamic load with the enlargement of postmitotic, terminally differentiated cardiac myocytes. Such hypertrophic changers are characterized by alternations in sarcomeric organization and gene expression. Previously, we estabilished a role for a nonreceptor tyrosine kinase, focal adhesion kinase, in signaling the changes in cytoskeletal organization associated with hypertrophy. Here, we report on data suporting a key role for p130Cas in this process,. In neonatal cardiac myocytes FAK, Cas and paxillin are located in sarcomeric Z-lines, suggesting that the Z-line is an important signaling locus in these cells. The expression of different Cas mutants results in a nearly complete loss of sarcomeric organization in these myocytes. Moreover, expression of the C-terminal focal adhesion-targeting domain of FAK both disrupted sarcomeric organization and interfered with the localization of endogenous Cas to Z-lines. These findings suggest that the association of FAK and Cas and the preservation of multiple protein-interaction motifs of Cas are required for the correct assembly of sarcomeres in cardiac myocytes.


    1013/2523

    Tytuł oryginału: A paradigm for quantifying ventricular contraction.
    Autorzy: Palladino Joseph L., Noordergraaf Abraham
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.331-335, il., tab., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: The left ventricle may be described as a time, volume and flow dependent pressure generator. First, isovolumic pressure is measured at various and-diastolic volumes. Next, pressure is adjusted to account for small changes accompanying ejection, denoted the ejection effect. The resulting analytical function can describe pressure generation and ventricular outflow of the ventricle under a wide range of contractile and vascular conditions. This paradigm is unique in separating isvolumic from ejecting ventricular properties, as well as ventricular from vascular conditions.


    1014/2523

    Tytuł oryginału: A dosimetric method of total body irradiation.
    Autorzy: Vrtar Mladen
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.337-340, il., bibliogr. 6 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The determination of the dose delivered to the body during Total Body Irradiation (TBI) is not easy, as direct measurements are impossible. This article presents the intention to develop a systematic and simple method for absorbed dose determination in 60Co TBI using mid plane dose factors (MDF) and external measurements, i.e. entrance and exit dose readings by semiconductor detectors. In order to perform the radiation field analysis prior to TBI treatment, a special silicon n-type detector with increased sensitivity (1200 nC/Gy) was used. The dependence of the calibration factor of this detector exposed to different dose rates in standard and TBI conditions was investigated. A theoretical model of anthropomorphic phantoms of cylindrical ellipsoid shape was estabilished. The software made it possible to generalize the applicability of TBI dosimetry to any individual case of real patient data. A quality assurance analysis of dosimetric results of 350 patients, who underwent TBI during a 17-year period, was performed.


    1015/2523

    Tytuł oryginału: Cell markers in the recognition of acute myeloblastic leukaemia subtypes.
    Autorzy: Andoljsek Dusan, Preloznik Zupan Irena, Zontar Darja, Cernelc Peter, Mlakar Uros, Modic Mojca, Pretnar Joze, Zver Samo
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.343-345, tab., bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • onkologia
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The diagnosis of acute myeloblastic leukaemia (AML) is based on cell morphology, cytogenetic and molecular changes, cell markers and clinical data. Our aim was to estabilish whether morphology and cell markers are comparable in the evaluation of AML. Bone marrow smears were analysed, and flow cytometry and monoclonal antibodies were used to determine cell type and maturity. Morphology and cell markers correlated differently in different AML subtypes.


    1016/2523

    Tytuł oryginału: Modelling the state of bone cysts by statistical analysis of intensities of X-ray images.
    Autorzy: Brecelj Janez, Bole Velimir
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.347-349, il., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The subject of this article is the state of a benign bone disease. The principle aim of this study is the construction of a statistical model for estimating the otherwise unobservable variable for the state of the disease. The distribution of intensity of X-ray images of the affected part and the healthy part of the bone are evaluated. Quantiles of both distributions are used in the estimation of a multinomial logit model by which the variable for the state of the disease is quantified.


    1017/2523

    Tytuł oryginału: Equinatoxin II-induced lysis of the cultured endothelial cell line ECV-304.
    Autorzy: Bunc Matjaz, Rozman Janez, Starc Radovan, Macek Peter, Suput Dusan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.351-353, il., tab., bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Equinatoxin II (EqT II) is a pore-forming actinoporin. Its lethality in rat tissue is due to cardio-respiratory effects. The toxin contracts the vascular smooth muscle only in the presence of intact endothelium. In our study, its effects on the endothelial cell culture ECV-304 were tested. The EqT II effects were dose-dependent and were influenced by calcium ions and sucrose. The obtained results support the conclusion that calcium ions are the intracellular messengers of the EqT II effects on the isolated endothelial cells.


    1018/2523

    Tytuł oryginału: Nicardipine diminished equinatoxin II-induced decrease of coronary flow in isolated rat and pig hearts.
    Autorzy: Bunc Matjaz, Rozman Janez, Vidmar Alenka, Rakovec Peter, Drevensek Gorazd, Budihna Metka V., Suput Dusan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.355-357, bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • Świnie
  • płeć męska

    Streszczenie angielskie: Equination II (EqT II) is a basic, cardiotoxic polypeptide. The vasoconstrictory effect of the toxin on isolated porcine coronary arteries was diminished by nicardipine, an L-type calcium channel antagonist. A comparison was made of the effects of EqT II alone and EqT II in the presence of nicardipine on the coronary flow in porcine and rat hearts isolated according to Langendorff's method. In both models EqT II decreased coronary flow in a dose-dependent manner and there were no statistically significant differences between the two models (p 0.05). However, 1ćM nicardipine diminished the effects of EqT II on coronary flow in isolated porcine hearts more than in isolated rat hearts (p 0.05). The results suggest that the activation of L-type calcium channels is one of the mechanisms involved in the lowering of coronary flow induced by EqT II.


    1019/2523

    Tytuł oryginału: The importance of HLA DQB1*0602 typing in Slovene patinets with narcolepsy.
    Autorzy: Dolenc-Grosel Leja, Vodusek David B.
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.359-360, tab., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • neurologia
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The HLA class II region genes DQB1*0602 and DQA1*0102 are currently the best genetic predictors for narcolepsy in humans. The aim of this study was to identify the HLA DQ alleles (DQB1*0602 and DQA1*0102) in Slovene sporadic narcoleptic patients. 11 patients who fulfilled ICSD criteria for narcolepsy entered the study. DRB1*1501 DQB1*0602 was present in all the patients while DQA1*0102 was absent in 2 patients. We propose that DQB1*0602 typing is important in diagnosing narcolepsy in Slovene patients.


    1020/2523

    Tytuł oryginału: The outcome of autologous chondrocyte transplantation treatment of cartilage lesions in the knee.
    Autorzy: Drobnic Matej, Kregar-Velikonja Nevenka, Radosavljevic Damjan, Gorensek Miro, Koritnik Branko, Malicev Elvira, Wozniak Gordana, Jeras Matjaz, Knezevic Miomir
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.361-363, il., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Recent results of the clinical outcome of autologous chondrocyte transplantation (ACT) treatment in a group of 28 patients with focal femoral condyle cartilage lesions revealed a correlation trend with the quality of the in vitro cell culture matrix-protein synthesis. No impact of the patients' age and chondrocyte cryopreservation prior to implantation was observed. Further studies are needed to confirm the preliminary results.


    1021/2523

    Tytuł oryginału: Biomechanical analysis of Chiari osteotomy.
    Autorzy: Herman Simon, Kralj-Iglic Veronika, Iglic Ales, Antolic Vane, Herman Srecko
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.365-366, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • chirurgia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The decrease in contact hip joint stress after Chiari osteotomy is studied using a mathematical model. In the model, additional coverage of the femoral head by the ala ossis ilei segment is taken into account. It is shown that this additional coverage significantly decreases stress, mostly by the indirect effect caused by the shift of the stress pole.


    1022/2523

    Tytuł oryginału: The muscle adaptation process as a result of pathological changes or specific training procedures.
    Autorzy: Kersevan Katarina, Valencic Vojko, Djordjevic Srdjan, Simunic Bostjan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.367-369, il., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Muscle responses to tetanic electrical stimulation were detected by the non-invasive tensiomyographic (TMG) measuring method. The main objective of this study was to find out whether the TMG measuring method is suitable for monitoring the unfused tetanus (stimulation frequencies ranging from 1 Hz to the fusion frequency (ff) - the frequency at which tetanus occurs), and whether this monitoring provides any information on skeletal muscles, structural or functional changes. The muscle adaptation process was observed in damped unfused tetanus (DUT). The measured results in the clinical environment as well as on the sports field indicate that DUT is caused by a type II muscle fibres fatigue process. Separate observation of type II muscle fibres enables more efficient treatment and observation of pathological changes, and helps professional athletes and their trainers to better understand the influence of training stimulii on the training process.


    1023/2523

    Tytuł oryginału: Echocardiographic evaluation of regional left atrial function after rapid atrial pacing.
    Autorzy: Kozelj Mirta, Zupan Igor, Butinar Janos, Seliskar Alenka, Rakovec Peter
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.371-373, tab., bibliogr. 6 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • psy

    Streszczenie angielskie: Rapid regular atrial pacing (RAP) produces changes in atrial function similar to those caused by atrial fibrillation in animal models. Left atrial appendage (LAA) function represents regional atrial function. The aim of our study was to investigate the influence of RAP on left atrial regional function and to evaluate the reversibility of changes after terminationtermination of pacing in a canine model. Eight dogs were subjected to RAP (400 bpm) for 16 days. Transesophageal echocardiography was performed at baseline, immediately after RAP and 4 weeks after the terminationtermination of RAP. The LAA peak late emptying velocity (LAA-E) and filling wave (LAA-f) were measured. LAA-E velocities were significantly reduced and filling wave velocities (LAA-f) were significantly less negative after RAP compared with the baselline values. Four weeks after terminationtermination of pacing, the LAA-E and LAA-f velocities were normal. RAP results in impaired regional atrial systolic and diastolic function. The changes were completely reversible 4 weeks after terminationtermination of pacing. These results suggest that the LAA is mechanically stunned after RAP.


    1024/2523

    Tytuł oryginału: Differences in the oxygenation of the forearm muscle during isometric contraction in trained and untrained subjects.
    Autorzy: Usaj Anton
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.375-377, il., bibliogr. 2 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of this study was to test a hypothesis that a longer duration of isometric contraction is related to an increased oxygenation status of the muscle. A group of trained rock climbers and untrained subjects performed 15 kp sustained isometric contraction until fatigue set in. The oxygenation status was assessed using near infrared spectroscopy (ISS, USA). The results support the hypothesis. The concentration of relative oxygenated hemoglobin was higher in the rock climbers than in the untrained subjects. The relative total hemoglobin did not differentiate the two groups enough to show that blood volume also strongly influences contraction time.


    1025/2523

    Tytuł oryginału: The effect of proprioceptive training in patients with recurrent dislocation of the patella.
    Autorzy: Vengust Rok, Strojnik Vojko, Pavlovicic Vinko, Antolic Vane, Zupanc Oskar
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.379-380, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Eleven patients with recurrent dislocation of the patella were subjected to knee proprioceptive training. Patients exhibited a gain in their Lysholm and Activity scores (p 0.03 and 0.009). No patient needed operative procedure.


    1026/2523

    Tytuł oryginału: Hazard identification for 3,5-dichlorophenol in the aquatic environment.
    Autorzy: Zagorc-Koncan Jana, Zgajnar Gotvajn Andreja, Tisler Tatjana
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.381-382, bibliogr. 5 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The risk assessment of substances in various environmental compartments is essential for their proper, safe and environmentally friendly production, handling, use and final deposition or destruction. Hazard identification is an important part of risk assessment. The aim of our research was to present a methodology for the hazard identifuication of substances dangerous to the aquatic environment according to the 93/21/EEC Directive relating to the classification, packaging and labelling of dangerous substances, from the adverse effect assessment of chemicals in European Union. A battery of toxicity tests and biodegradability studies with 3,5-dichlorophenol were performed. The substance was classified as toxic to aquatic organisms with possible long-term adverse effects. The presented methodology assures reliable data for the classification and labelling of substances according to their harmful effect on aquatic biota, suitable for the competent authorities at the national and EU level.


    1027/2523

    Tytuł oryginału: Impaired sinus node function and global atrial conduction time after high rate atrial pacing in dogs.
    Autorzy: Zupan Igor, Kozelj Mirta, Butinar Janos, Rakovec Peter
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.383-384, tab., bibliogr. 4 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • psy

    Streszczenie angielskie: In animal and human studies, it has been shown that atrial fibrillation shortens the atrial refractory period and impairs its rate adaptation. The objective of this study was to evaluate the effects of high-rate pacing on sinus node function and intra-atrial conduction. Eight dogs were subjected to rapid atrial pacing (AP) at 400 bpm for 16 days. Sinus node recovery time (SNRT) and P-wave duration were measured at baseline, immediately after AP and four weeks after the termination of AP. SNRT immediately after AP was significantly prolonged at all pacing rates compared to the baseline values. P-wave duration was significantly longer after AP relative to the baseline values. All the variables were completely reversible four after the termination of pacing. Rapid AP induces sinus node dysfunction and prolongs the intra-atrial conduction time. IT is possible that the electrical remodelling extends to the sinus node as well.


    1028/2523

    Tytuł oryginału: Neuronal basis of neuroleptic-induced extrapyramidal side effects.
    Autorzy: Ossowska Krystyna
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.299-312, il., bibliogr. 80 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: The article reviews presently commonly accepted concepts of neuronal basis of neuroleptic-induced extrapyramidal side effects. The data obtained both, in humans and laboratory animals, point to the blockade of a large number of the striatal dopamine D2 receptors by neuroleptics as a primary cause of these disturbances. This phenomenon leads to the appearance of parkinsonian symptoms shortly after therapy commencement. On the other hand, chronic administration of neuroleptics evokes supersensitivity to dopamine connected with the increased number of D2 receptors and supersensitivity of D1 receptors, which can be significant for the development of tardive dyskinesia. Primary and secondary changes in the function of dopamine receptors lead to partially opposite, pathological changes in the activity of neuronal pathways connecting the basal ganglia. Besides functional changes, neuroleptic-induced lesions of the striatal neurons and genetic predispositions can also play a role in tardive dyskinesia.


    1029/2523

    Tytuł oryginału: Neuroprotective role of adenosine in the CNS.
    Autorzy: Wardas Jadwiga
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.313-326, il., tab., bibliogr. 117 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: It is well estabilished that in the CNS, endogenous adenosine plays a pivotal role in neurodegeneration. A low, nanomolar concentration of adenosine is normally present in the extracellular fluid, but it increases dramatically during enhanced nerve activity, hypoxia or ischemia. In these pathological conditions, adenosinergic transmission-potentiating agents, which elevate adenosine level by either inhibiting its degradation (adenosine deaminase and kinase inhibitors) or preventing its transport, offer protection against ischemic or excitotoxic neuronal damage. The directly acting adenosine A1 receptor agonists are known to mediate neuroprotection, mostly by the blockade of Ca2+ influx, which results in the inhibition of glutamate release and reduction of its excitatory effects at a postsynaptic level. More recent data have shown that antagonists of adenosine A2A receptors markedly reduce cerebral ischemic damage in animal models of focal and global ischemia. Moreover, these compounds attenuate the neuronal loss induced by excitatory amino acids (EAA). A neuroprotective effect of adenosine A2A receptor antagonists was also shown in animal models of Parkinson's disease (MPTP, 6-OHDA, methamphetamine). Hence, it might be suggested that adenosine A2A receptor antagonists may represent a novel strategy in the therapeutic approach to pathologies characterized by acute or chronic neurodegenerative events, since they not only reverse motor impairment but can act as neuroprotective compounds by promoting cell survival.


    1030/2523

    Tytuł oryginału: In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors.
    Autorzy: Wesołowska Anna
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.327-341, il., tab., bibliogr. 65 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In recent years much attention has been focused on the functional importance of 5-HT5, and 5-HT6 and 5-HT7 receptors in the pathogenesis of neuropsychiatric and other diseases. In this connection, intensive studies with ligands of these receptors are currently in progress. Recognition of the structural characteristics responsible for the bilding of a ligand molecule to an appropriate receptor, and development of an active complex have reached an advanced stage in the research for selective compounds. This review was undertaken to summarize the results of structure-activity relationship studies with ligands of 5-HT5, 5HT6 and 5-HT7 receptors. Additionally, some data on localization, pharmacological properties and the functional role of those receptors were reported.


    1031/2523

    Tytuł oryginału: Effect of antidepressant drugs on the hypothalamic-pituitary-adrenal axis activity and glucocorticoid receptor function.
    Autorzy: Budziszewska Bogusława
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.343-349, bibliogr. 50 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • endokrynologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis is the main biochemical change, besides disturbed monoaminergic neurotransmission, observed in the patients suffering from a major depression. High incidence of depression in Cushing's syndrome as well as antidepressant effects of adrenocortical enzyme inhibitors in major depression [17, 20, 29, 42] support hypothesis that hyperactivity of HPA axis may be involved in pathogenesis of depression.


    1032/2523

    Tytuł oryginału: Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats.
    Autorzy: Papla Iwona, Filip Małgorzata, Przegaliński Edmund
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.351-357, il., bibliogr. 35 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study, we investigated the role of 5-HT1B receptors located in the ventral tegmental area (VTA) in the amphetamine-induced locomotor hyperactivity in rats. Male Wistar rats, implanted bilaterally with cannulae in the VTA were infused with saline (0.2 ćl/side), GR 55562 (an antagonist of 5-HT1B receptors; 0.1 - 1 ćg/side) or CP 93129 (an agonist of 5-HT1B receptors; 0.003 - 0.03 ćg/side) immediately prior to the injection of saline (1 ml/kg, ip) or amphetamine (0.5 mg/kg, ip). The monitoring of locomotor activity in photobeam chambers began at once and proceeded for 60 min. Neither GR 55562 nor CP 93129 affected basal locomotor activity. Pretreatment with GR 55562 (0.1 - 1 ćg/side) did not affect the locomotor hyperactivity evoked by amphetamine. On the other hand, microinjections of CP 93129 (0.01 - 0.03 ćg/side) enhanced the amphetamine-induced hyperlocomotor activity. GR 55562 (1 ćg/side) markedly reduced the enhancing effects of CP 93129 (0.01 ćg/side) on the amphetamine-induced hyperactivity. These findings indicate that 5-HT1B receptors located in the VTA do not play a major role in the hyperlocomotion elicited by amphetamine, whereas their activation may modulate the behavioral response to the psychostimulant.


    1033/2523

    Tytuł oryginału: Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity.
    Autorzy: Poleszak Ewa, Malec Danuta
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.359-366, il., bibliogr. 43 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The influence of adenosine receptor agonists and antagonists on cocaine and amphetamine-induced hyperactivity was examined in mice. All adenosine receptor agonists significantly decreased the locomotor activity in mice, and the effects were dose-dependent. It seems that adenosine A1 and A2 receptors might be involved in this reaction. Moreover, all adenosine receptor agonists: 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680), A2A receptor agonist, N6-cyclopentyladenosine (CPA), A1 receptor agonist, and 5'-N-ethylcarboxamidoadenosine (NECA), A2/A1 receptor agonist significantly and dose-dependently decreased cocaine-induced locomotor activity. CPA reduced cocaine action at the doses which, given alone, did not influence motility, while CGS 21680 and NECA decreased the action of cocaine at the doses which, given alone, decreased locomotor activity in animals. These results suggest the involvement of both adenosine receptors in the action of cocaine although agonists of A1 receptors seem to have stronger influence on it. The selective blockade of A2 adenosine receptor by DMPX (3,7-dimethyl-1-propargylxanthine) significantly enhanced cocaine-induced locomotor activity of animals. Caffeine had similar action but the effect was not significant. CPT (8-cyclopentyltheophylline) - A1 receptor antagonist, did not show any influence in this test. Similarly, all adenosine receptor agonists decreased amphetamine-induced hyperactivity, but at the higher doses than those which were active in cocaine-induced hyperactivity. The selective blockade of A2....


    1034/2523

    Tytuł oryginału: Effect of cocaine and amphetamine on biosynthesis of proenkephalin and prodynorphin in some regions of the rat limbic system.
    Autorzy: Turchan Jadwiga, Maj Marcin, Przewłocka Barbara, Przewłocki Ryszard
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.367-372, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: A vast body of evidence points to the role of the limbic system in the mechanism of drug dependence. Opioid peptides localized in the limbic system may play a role in central effects of substances of abuse. The goal of the present study was to investigate the influence of acutely and chronically administered drugs of abuse, cocaine and amphetamine on biosynthesis of prodynorphin and proenkephalin in the rat amygdala, the structure involved in the mechanism of drug addiction. Acute injection of cocaine (20 mg/kg ip every hour for 3 h) or amphetamine (2.5 mg/kg) did not changed or decreased the level of proenkephalin mRNA in the central nucleus of the amygdala. In contrast, the level of prodynorphin mRNA was significantly increased in this structure after cocaine. Repeated cocaine administration (20 mg/kg ip every hour for 3h, for 5 days) had no effect on the proenkephalin and prodynorphin mRNA in the central nucleus of the amygdala. Chronic amphetamine (2.5 mg/kg twice daily for 5 days) administration decreased proenkephalin and increased prodynorphin mRNA level in the central nucleus of the amygdala (at 24 and 48 h). Moreover, significant increase in prodynorphin mRNA level was observed in the hippocampal dentate gyrus after acute (cocaine) and chronic (cocaine, amphetamine) administration of the psychostimulants. The observed adaptive changes in the activity of two opioid systems in two structures of the limbic system, central nucleus of amygdala and hippocampus, may contribute to the neurochemical mechanism of drug addiction after psychostimulants. These studies also....


    1035/2523

    Tytuł oryginału: Repeated treatment with selective serotonin reuptake inhibitors but not anxiolytics prevents the stress-induced deficit of fighting behavior.
    Autorzy: Ossowska Grażyna, Żebrowska-Łupina Iwona, Danilczuk Zofia, Klenk-Majewska Bożena
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.373-380, il., tab., bibliogr. 46 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Several animal models of "depression" have been examined. One of them is chronic unpredictable stress (CUS)-induced deficit of fighting behavior in rats. In the present study, we compared the effects of two antidepressants (fluoxetine or fluvoxamine) and three anxiolytics (buspirone, lorazepam or oxazepam) on the electric footshock-induced fighting behavior in the pairs of male Wistar rats exposed to CUS procedure (16-day application of various unpredictable stressors). It was found that, in chronically stressed rats, the number of fighting attacks was significantly reduced (by about 70 p.c.). Prolonged (for 14 days) treatment of rats with fluoxetine or fluvoxamine (both at the dose of 10 mg/kg/day) counteracted the deficit of aggression induced by the chronic stress,. On the contrary, the anxiolytics: lorazepam (0.5 mg/kg/day), oxazepam (5 mg/kg/day) or buspirone (0.2 mg/kg/day) administered for 14 days, did not modify the deficit of fighting induced by CUS procedure. It must be underlined that prolonged treatment with all used drugs did not change the intensity of fighting in normal (unstressed) rats. In conclusion, prolonged tratment with antidepressant drugs prevents the CUS-induced deficit of fighting behavior, whereas no beneficial effect of anxiolytic agents was found.


    1036/2523

    Tytuł oryginału: Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors.
    Autorzy: Rogóż Zofia, Wróbel Andrzej, Dlaboga Daniel, Dziedzicka-Wasylewska Marta
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.381-389, tab., bibliogr. 42 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Mirtazapine (MIR) is an antidepressant drug which enhances noradrenergic and serotonergic 5-HT1A neurotransmission via antagonistic action at central ŕ2-adrenergic autoreceptors and heteroreceptors. We reported earlier that tricyclic antidepressants administered repeatedly induced adaptive changes in the central dopaminergic D2/D3 receptors. Therefore, we designed our present study to determine whether repeated MIR treatment could evoke similar effect. The experiments were carried out on male Wistar rats. MIR was administered at a dose of 10 mg/kg once or repeatedly (twice daily for 14 days). The obtained results showed that MIR administered repeatedly potentiated the hyperlocomotion induced by D-amphetamine but not by quinpirole or 7-OH-DPAT. Biochemical study showed that MIR administered repeatedly decreased the binding of [3H]quinpirole (a D2/D3 receptor agonist) in the shell part of the nucleus accumbens septi and in the islands of Calleja but did not change the binding in the nucleus caudatus (medial or lateral). On the other hand, both acute and repeated drug treatment did not change the [3H]7-OH-DPAT (a D3 receptor agonist) binding sites in the islands of Calleja as well as in the shell part of nucleus accumbens septi. In addition, MIR did not alter the level of mRNA encoding dopamine D2 receptors, not only after repeated but also after acute treatment. The above results indicate that repeated MIR administration did not induce any adaptive change (behavioral and biochemical changes) in the dopaminergic D2/D3 system.


    1037/2523

    Tytuł oryginału: Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice.
    Autorzy: Wesołowska Anna, Borycz Jolanta, Paluchowska Maria H., Chojnacka-Wójcik Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.391-399, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: In this study, we examined the role of 5-hydroxytryptamine (5-HT)1A and ŕ1-adrenergic receptors in the hypothermia induced by 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine (NAN-190) and its analogs, 1-(2-methoxyphenyl)-4-[(4-succinimido)butyl]piperazine (MM77) and trans-1(2-methoxyphenyl)-4-[4-(2-phthalimido)cyclohexyl]piperazine (MP245), which - like NAN-190 - showed a high affinity for 5-HT1A and ŕ1-adrenoceptors. Administration of NAN-190 (a partial agonist of presynaptic and an antagonist of postsynaptic 5-HT1A receptors and ŕ1-adrenoceptors), MM77 and MP245 (antagonists of postsynaptic 5-HT1A receptors), as well as 8-OH-DPAT (a 5-HT1A agonist) and prazosin (an ŕ1-adrenoceptor antagonist) induced a dose-dependent hypothermia in mice. The silent antagonist of 5-HT1A receptors, WAY 100635, which abolished the hypothermic effect of 8-OH-DPAT, inhibited the hypothermia induced by NAN-190 administered at a dose of 1 mg/kg (but not 2 mg/kg) and by MP245 (0.5 and 1 mg/kg), but failed to change the MM77 (1 and 4 mg/kg)-induced decrease in body temperature in mice. The ŕ1-adrenoceptor agonist St587, which reduced the hypothermic effect of prazosin, inhibited the decrease in body temperature evoked by NAN-190 at the higher dose and by MP245at both the doses used, but did not affect the MM77-induced hypothermia in mice. The obtained results suggest that the hypothermia in mice induced by NAN-190 and its constrained analog MP245 is connected with stimulation of 5-HT1A receptors and with blockade of ŕ1-adrenoceptors, participation of these receptors not being equivalent, though. The origin of the hypothermia evoked by MM77 is still unknown.


    1038/2523

    Tytuł oryginału: Using reverse transcription and a competitive polymerase chain reaction for quantification of ŕ1B-adrenoceptor mRNA.
    Autorzy: Kreiner Grzegorz, Sanak Marek, Zelek-Molik Agnieszka, Nalepa Irena
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.401-405, il., bibliogr. 10 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Molecular cloning studies have revealed the existence of three subtypes of ŕ1-adrenergic receptor (ŕ1-AR), namely ŕ1A, ŕ1B and ŕ1D. They are encoded by separate genes and have distinct pharmacological profiles. In rats' brain, the expression of mRNA for subtypes of an ŕ1-AR is partially structure-dependent. Our previous studies employing Northerm blot analysis of mRNA have shown that in the hippocapmus, where ŕ1A predominates, the ŕ1B receptor (ŕ1B-AR) was almost undetectable. The goal of the present study was to estabilish the method of reverse transcription and competitive polymerase chain reaction (RT-cPCR) to quantify a steady state level of ŕ1B-AR mRNA in the hippocampus, prefrontal cortex and thalamus, and to compare the ŕ1B-AR' pattern of expression with that revealed by Northern blot analysis. Our results have shown that ŕ1B-AR is similarly represented in the thalamus and prefrontal cortex. In the hippocampus, ten times lower expression of ŕ1B mRNA has been demonstrated with RT-cPCR, which was below a detection limit of Northern blot hybridization technique.


    1039/2523

    Tytuł oryginału: Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4.
    Autorzy: Wójcikowski Jacek, Pichard-Garcia Lydiane, Maurel Patrick, Daniel Władysława A.
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.407-410, il., bibliogr. 10 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca kazuistyczna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The effects of perazine on the activities of CYP1A2 and CYP3A4 in a primary culture of human hepatocytes of one patient were studied in vitro. The CYPs activities were assessed by measuring the rate of acetanilide 4-hydroxylation (CYP1A2) and cyclosporine A oxidation (CYP3A4) after treatment with TCDD (a CYP1A subfamily inducer) or rifampicin (mainly a CYP3A4 inducer). The amounts of the metabolities formed in hepatocytes were assayed in the extracellular medium using the HPLC method. TCDD and rifampicin induced the formation of 4-hydroxyacetanilide and cyclosporine A metabolities (monohydroxycyclosporine A, dihydroxycyclosporine A, N-desmethylcyclosporine A), respectively. The formation of 4-hydroxyacetanilide was strongly inhibited by three different concentrations of perazine (10, 25 and 50 ćM) reaching 8,3 and 2 p.c. of the control value, respectively. In the case of CYP3A4 activity, no such an effect of perazine was observed. Perazine showed only a week inhibition of the activity of cyclosporine A oxidase (to 96-86 p.c. of the control value). The obtained results suggest a strong inhibitory effect of perazine on human CYP1A2 activity with predicted Ki value similar to those of the known for CYP1A2 inhibitors, such as furafylline and fluvoxamine.


    1040/2523

    Tytuł oryginału: Beware the wolves are about.
    Autorzy: McLellan I.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.42-44 - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1041/2523

    Tytuł oryginału: Operating room air pollution - clinical experience from Germany.
    Autorzy: Taeger K., Harth M.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.44-46, tab., bibliogr. 3 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • chirurgia
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1042/2523

    Tytuł oryginału: Anaesthesia and risk.
    Autorzy: Aitkenhead A. R.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.49-53, tab., bibliogr. 17 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1043/2523

    Tytuł oryginału: Some anesthetic aspects in vascular neurosurgery.
    Autorzy: Lewelt W.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.53-55, bibliogr. 8 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1044/2523

    Tytuł oryginału: Head trauma, cerebral vascular damage and secondary brain ischemia.
    Autorzy: DeWitt D. S., Prough D. S.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.55-61, tab., bibliogr. 96 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1045/2523

    Tytuł oryginału: The open lung management in anesthesia and intensive care.
    Autorzy: Lachmann B., Haitsma J. J.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.61-64, il., bibliogr. 20 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • anestezjologia
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1046/2523

    Tytuł oryginału: Atelectasis during anaesthesia and methods to prevent it.
    Autorzy: Hedenstierna G.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.67-69, il., bibliogr. 18 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • pulmonologia
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1047/2523

    Tytuł oryginału: Apneic ventilation, experimental and clinical research.
    Autorzy: Babinski M. F.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.69-71 - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca historyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • historia nowożytna
  • historia XX wieku
  • historia po r.1945


    1048/2523

    Tytuł oryginału: Non obstetric emergencies in pregnant women.
    Autorzy: May A. E.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.93-94, bibliogr.7 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ginekologia i położnictwo
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża


    1049/2523

    Tytuł oryginału: Interventional neuroradiology and anesthesia.
    Autorzy: Lewelt W.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.94-97, bibliogr. 5 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • anestezjologia
  • neurologia
  • radiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1050/2523

    Tytuł oryginału: Are the problems of premedication solved in paediatric anaesthesia?
    Autorzy: Holzki J.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.100-102, il., bibliogr. 10 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • farmacja
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1051/2523

    Tytuł oryginału: Low flow anaesthesia in infants and children.
    Autorzy: Meakin G. H.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.102-105, bibliogr. 26 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • pediatria
  • anestezjologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta


    1052/2523

    Tytuł oryginału: Significant back problems and regional anaesthesia.
    Autorzy: May A. E.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.108-110, bibliogr. 12 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża


    1053/2523

    Tytuł oryginału: The history of modern CPR - in my time.
    Autorzy: Baskett P. J. F.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.120-122 - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca historyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XX wieku
  • historia po r.1945


    1054/2523

    Tytuł oryginału: Controversies in emergency medicine.
    Autorzy: Dick W. F.
    Źródło: Anestezjol. Intens. Ter. 2002: 34 supl. 1: XIV Międzynarodowy Zjazd Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii : wykłady i streszczenia s.124-128, il., tab., bibliogr. 28 poz. - 14 Międzynarodowy Zjazd Polskiegio Towarzystwa Anestezjologii i Intensywnej Terapii Lublin 11-14.09. 2002
    Sygnatura GBL: 305,376

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1055/2523

    Tytuł oryginału: Age-adjustment of HRV measures and its prognostic value for risk assessment in patients late after myocardial infarction.
    Autorzy: Sosnowski Maciej, MacFarlane Peter W., Czyż Zbigniew, Skrzypek-Wańha Janina, Boczkowska-Gaik Ewa, Tendera Michał
    Źródło: Int. J. Cardiol. 2002: 86 (2/3) s.249-258, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aims of our study were: (1) to establish the normal limit of the heart rate variability (HRV) indices in a healthy population and in its fourage-related subgroups, including a new HRV index, HRV fraction; and (2) to analyse the frequency and predictive value of abnormally low HRV in a population of post-infarction patients in respect to the cut-points chosen (raw or age-adjusted). Methods: Normal population of 296 healthy subjects (81 f, 215 m, aged 47 ń 10 years) and post-infarction population of 298 patients ( 3 months after acute MI, 65 f, 233 m, aged 56 ń 10) were examined. The normal population was divided into 4 subsets based on age at entry: 35, 35-44, 45-54 and 54 years. Based on a 24 h ECG the standard HRV analysis was performed to obtain the following indices: mean RR interval, SDNN and SDANN. A new index of HRV, HRV fraction (HRVF, p.c.) was calculated based on a numercial processing of the RR intervals return map. All patients were followed for 24 months. The endpoints of the study were death (of any reason) and cardiac death. Results: Means and normal limits for SDNN, SDANN and HRVF were: 147 ń 36 ms [95 p.c. CI 89-220], 136 ń 36 ms [79-212] and 53 ń 9 p.c. [35-68]. The HRV values below the lower normal limit (LNL) were observed in 20-25 p.c. of post-MI patients. During a 2 year follow-up there were 36 deaths (total mortality 12.1 p.c.), while cardiac mortality was 9.1 p.c. (27 cases). The prognostic value of the analysed indices was similar (sens 53-61 p.c., spec 79-84 p.c., PPV 2-26 p.c., NPV 93-94 p.c.)...


    1056/2523

    Tytuł oryginału: Unexpected eosinophilic mycoarditis in a young woman with rapidly progressive dilated cardiomyopathy.
    Autorzy: Bilińska Zofia T., Bilińska Maria, Grzybowski Jacek, Przyłuski Jakub, Michalak Ewa, Walczak Ewa, Wagner Teresa, Rużyłło Witold
    Źródło: Int. J. Cardiol. 2002: 86 (2/3) s.295-297, ml., bibliogr. 5 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: We present the case of 23-year-old woman with good living conditions, one year history of ventricular arrhythmia and 6 months history of decreased exercise tolerance, who was found to have dilated cardiomyopathy after aborted sudden death. Endomyocardial biopsy did not show specific findings. Within 3 months she develooped profound bradycardia requiring pacemaker implantation and refractory heart failure, treated with heart transplantation. Intense eosinophilic myocarditis was found in the explanted heart. Retrospective analysis of the patient's blood count revealed mild eosinophilia (eosinophil count: 0.86 x 109/1) on one examination only. Following heart transplantation the patient had persistent eisinophilia (eosinophil count: 0.62 x 109/1). Although there was no proven parasitic infestation, based on positive family history of Enterobius vermicularis infestation she was treated with broad-spectrum antiparasitic agent: albendazole and her eosinophil count returned to normal values. This case shows that active eosinophilic myocarditis may present clinically as progressive dilated cardiomyopathy with severe involvement of conduction system. Massive myocardial tissue eosinophilia occurred in the setting of mild and transient blood eosinophilia. Favourable outcome following antiparasitic treatment suggests a potential parasitic infestation as a cause of the disease.


    1057/2523

    Tytuł oryginału: Effect of angiotensin II on ANP-dependent guanylyl cyclase activity in cultured mouse and rat podocytes.
    Autorzy: Golos Magdalena, Lewko Barbara, Bryl Ewa, Witkowski Jacek M., Dubaniewicz Anna, Olszewska Agnieszka, Latawiec Elżbieta, Angielski Stefan, Stepiński Jan
    Źródło: Kidney Blood Press. Res. 2002: 25 (5) s.296-302, il., tab., bibliogr. 37 poz., sum.
    Sygnatura GBL: 313,314

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: The presence of a well-developed contractile apparatus is the feature determining mojor roles of podocytes in the renal glomeruli. Receptors for a variety of a variety of vasoactive hormones are expressed in these cells; however, most of the signaling pathways are still unknown and remain to be elucidated. Angiotensin II (Ang II) and atrial natriuretic peptide (ANP), due to their opposite action, are the major modulators of glomerular filtration. In podocytes, Ang II induces rise in intracellular calcium concentration, whereas ANP stimulates generation of cGMP. The present study was designed to check whether ANP-stimulated cGMP synthesis in podocytes might be affected by Ang II. Cultured rat (RP) and mouse (MP) podocytes were stimulated with ANP, in the absence or presence of Ang II and cyclic GMP was determined by RIA method. Co-incubation of podocytes with ANP and Ang II caused significant (p 0.01) suppression of ANP-dependent cGMP generation. The effect was prevented by saralasin, an inhibitor of angiotensin receptors. Phorbol-12-myristate-13-acetate (PMA) mimicked, whereas chelerythrine reversed inhibitory effect of Ang II. In conclusion, angiotensin II counteracts ANP-stimulated cGMP synthesis in cultured podocytes. It seems likely that the protein kinase C pathway is involved in this effect.


    1058/2523

    Tytuł oryginału: The nephrological issues raised during the clinical sessions in the Old Order (Jewish) Hospital of Warsaw.
    Autorzy: Rybus-Potępa Elżbieta, Marczewski Krzysztof
    Źródło: Nephrol. Dial. Transplant. 2002: 17 (12) s.2084-2086, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 312,872

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca historyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XIX wieku
  • historia XX wieku


    1059/2523

    Tytuł oryginału: Discrepancies in creatinine clearance in centenarians when calculated by two different mathematical formulas.
    Autorzy: Wieczorowska-Tobis Katarzyna, Mossakowska Małgorzata, Niemir Zofia, Bręborowicz Andrzej, Oreopoulos Dimitrios G.
    Źródło: Nephrol. Dial. Transplant. 2002: 17 (12) s.2274-2275, bibliogr. 4 poz.
    Sygnatura GBL: 312,872

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca opublikowana za granicą
  • list i notatka
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1060/2523

    Tytuł oryginału: Cell cycle in sporadic melanoma.
    Autorzy: Czajkowski Rafał, Drewa Tomasz, Woźniak Alina, Krzyżyńska-Malinowska Ewa
    Źródło: Int. J. Dermatol. 2002: 41 (9) s.550-556, il., bibliogr. 53 poz.
    Sygnatura GBL: 305,645

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Sporadic melanoma is a neoplasm whose etiology has been fully investigated. Contemporary achievements in molecular biology have made it possible to localize the genes whose damage can contribute to the initiation of neoplastic transformation of malanocytes and lead to a progression of the disease. The majority of these genes are responsible for the correct progression of phase G1 of the cell cycle. Phase G1 of the cell cycle is subject to control by many protooncogenes and antioncogenes, wihich constitute the pRb or p53 pathway, damage to which can lead to the development of malignant melanoma. The present paper discusses disorders inthe control of phase G1 of the cell cycle in sporadic melanoma.


    1061/2523

    Tytuł oryginału: Oxidative stress and neutrophil activation - the two keystones of ischemia/reperfusion injury.
    Autorzy: Kamiński Karol A., Bonda Tomasz A., Korecki Janusz, Musiał Włodzimierz
    Źródło: Int. J. Cardiol. 2002: 86 (1) s.41-59, il., bibliogr. 212 poz.
    Sygnatura GBL: 305,693

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: The widespread introduction of fibrinolytics and recently also PTCA in the treatment of myocardial infarction has changed the picture of modern cardiology. But this therapy also raises new problems and challenges. One of them is the occurrence of ectensive tissue injury caused by reperfusion. Reinstitution of oxegen to the ischemia tissues initiates various processes leading to generation of reactive oxygen species (ROSs). Acting on the plasma membrane ROS damage its organization and release various proinflammatory agents. Different proteins, including receptors, ionic channels, transporters or components of transduction pathways are substrates of oxidation by ROSs. Theis changed structure results in altered functioning and disruption of vital cellular processes. Another key factor of reperfusion injury is activation and infiltration of infarcted are by polymorphonuclear leukocytes (PMNs). Multiple studies identified stages of PMN activation and substances being involved in it. Main interest lies in cellular adhesion molecules, particularly selectins and á2 integrins, as their atagonists were repeatedly found to diminish neutrophil activation and infarct size. Nevertheless new publications strike at the foundations of the established order and confront the realtion between neutrophil infiltration and infarct size. PMNs are linked by close ties to other cells involved in inflammatory response. Seemingly also in cardiac ischemia-reperfusion injury, the activity of neutrophils is modulated by lymphocytes and macrophages. The article describes mutual interactions between different factors involved in the reperfusion injury that may enable preparing new treatments, hopefully as effective and successful as reperfusion therapy.


    1062/2523

    Tytuł oryginału: Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat.
    Autorzy: Dobrzyń A., Górski J.
    Źródło: Horm. Metab. Res. 2002: 34 (9) s.523-529, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 312,226

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: It has previously been shown that prolonged exercise of moderate intensity reduces the content of ceramide in each type of skeletal muscle. This was accompanied by a reduction in the activity of neutral, Mg++-dependent sphingomyelinase (the major enzyme responsible for ceramide formation from sphingomyelin) in the soleus and red gastrocnemius, but not in the white gastrocnemius (A. Dobrzyń and J. Górski, Am. J. Physiol.: Endocrinol. Metab. 282: E277 - E285, 2002). No other data on regulation of ceramide metabolism in contracting muscles are available. The aim of the present study was to examine the content of sphinganine (a key precursor of ceramide on the de novo synthesis route) and the content of sphingosine (the main product of ceramide catabolism) in different skeletal muscle types after two kinds of acute exercise. The experiments were carried out on 30 male Wistar rats, 250-280 g of body weight. The rats were divided equally into three groups: 1 - control, 2 - run until exhaustion (1200 m/h, + 10ř incline), 3 - a group in which the sciatic nerve was stimulated 10 min with tetanic pulses (60 pulses/min). Samples were taken of the soleus and of the red and white section of the gastrocnemius. These muscles are composed mostly of the slow-twitch oxidative, fast-twitchoxidative-glycolytic and fast-twitch glycolytic fibers, respectively. Lipids were extracted with chloroform/methanol. Sphinganine and sphingosine were quantified by high-performance liquid chromatography. Atrest, the content of sphinganine in ...


    1063/2523

    Tytuł oryginału: Expression of very late antigen-4 and lymphocyte function-associated antigen-1 on peripheral blood lymphocytes from patients with graves disease.
    Autorzy: Bossowski Artur, Urban Mirosława, Stasiak-Barmuta Anna, Turowski Dariusz
    Źródło: Pediatr. Res. 2002: 52 (4) s.533-537, il., bibliogr. 31 poz.
    Sygnatura GBL: 300,504

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the syudy was to estimate the expression of á1 integrin CD49d (very antigen-4), á2 integrin CD11a (lymphocyte function-associated antigen 1 alpha), l-selectin (CD62L), and intercellular adhesion molecule-1 [ICAM-1 (CD54)] on peripheral blood mononuclear cells in patients with Graves disease (GD0 (n = 45, mean age 15.9 ń 5.9 y), in patients with nontoxic nodular goiter (NTNG) (n = 25, mean age 15.2 ń 5.7 y), and in sex- and age-matched healthy control subjects (n = 25, mean age 15.9 ń 2.4 y). The expression of the lymphocyte adhesion molecules was analyzed by three-color flow cytometry. decreased percentages of CD49d+ and CD11a+ lymphocytes were observed in untreated Graves' patients in comparison to healthy controls (p 0.007, p 0.036) and non-toxic nodular goiter patients (p 0.006, p 0.019). The analysis of CD62L+ and CD54+ antigen expression on peripheral blood lymphocytes revealed increased percentages of L-selectin- and ICAM-1-positive cells in patients with GD (p 0.005 for CD62L, p 0.008 for ICAM-1) before methimazole therapy, compared with healthy controls. These abnormalities were absent in children with NTNG. In patients with unterated GD, a positive correlation was found between serum levels of free thyroxine and the percentage of CD54+ lymphocytes (r = 0.47, p 0.036). Statistically significant negative correlations existed between free tyroxine concentration in blood serum and the percentage of CD11a+ lymphocytes (r = -0.39,p 0.033). No such correlation was detected between the percentage of lymphocyte markers and serum levels of antithyroid antibodies...


    1064/2523

    Tytuł oryginału: Changes in the volume of temporal lobe structures related to Alzheimer's type dementia.
    Autorzy: Moryś Janusz, Bobek-Billewicz Barbara, Dziewiątkowski Jerzy, Bidzan Leszek, Ussorowska Dorota, Narkiewicz Olgierd
    Źródło: Folia Neuropathol. 2002: 40 (2) s.47-56, il., tab., bibliogr. 59 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • radiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We compared the volumes of the superior temporal gyrus, basolateral temporal area, parahippocampal gyrus, hippocampal head, amygdaloid body and the inferior horn of the lateral ventricle in 29 patients with dementia of Alzheimer's type (DAT) and in 14 cognitively normal controls. Measurements were performed on coronal MR images perpendicular to the long axis of the hippocampus then the raw data were normalised for intracranial volume. The volumes of all studied structures were significantly msaller in patients with DAT than in age-matched control group. The differences in the volume between DAT and age-matched control group were the largest for the amygdaloid body and the basolateral temporal area. The discriminant analysis including the volume of both the basolateral area and the left amygdaloid body allows for correct classification of 100 p.c. DAT patients and 93 p.c. controls. We conclude that the estimation of the volume of the amygdaloid body and basolateral temporal area seems to be the most important factor for DAT diagnosis.


    1065/2523

    Tytuł oryginału: An attempt at evaluating borderline conditions of Parkinson's disease and its preclinical stage on the basis of clincial and morphological correlation.
    Autorzy: Krygowska-Wajs Anna, Adamek Dariusz, Szczudlik Andrzej, Kałuża Józef
    Źródło: Folia Neuropathol. 2002: 40 (2) s.57-66, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the investigations was to find to what extent neurodegenerative changes develop in the brains of patients with no clinical symptoms of dementia, parkinsonism and other neurodegenerative diseases. It has been found that neurodegenerative pathology, as evaluated using immunohistochemical methods with monoclonal antibodies (Mab) against ubiquitin, tau protein, ŕ-synuclein, and á-amyloid, occurs more frequently than the presence of Lewy bodies. The degenerative changes involved the neurones of cerebral and cerebellar cortex, basal ganglia and medulla oblongata, where neurofibrillary tangles were found. Mab positive materials have been found in the cytoplasm of the cell body and the cell processes (axons) of the neurones and glial cells. Senile plaques, á-amyloid positive, were frequently noted.


    1066/2523

    Tytuł oryginału: Abnormal nerve conduction velocity as a marker of immaturity in childhood muscle spinal atrophy.
    Autorzy: Krajewska Grażyna, Hausmanowa-Petrusewicz Irena
    Źródło: Folia Neuropathol. 2002: 40 (2) s.67-74, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Motor conduction velocity (CV) was tested in 117 infants and children with proximal spinal muscular atrophy (SMA), aged 1-53 months, and in 99 age-adjusted healthy controls. The children were classified into SMA forms 1 and 2 according to SMA International Consortium Criteria. In all children CV was tested in four nerves and the following parameters were taken into account: distal latency, conduction velocity, amplitude of muscle response. The electromyography of muscles revealed neurogenic changes. In all cases of severe form 1 motor CV was markedly slowed, with significantly prolonged distal latency adn reduced amplitude of M response. In surviving children CV, although increasing with age, was always below the values of normal age-adjusted children. The slowing was particularly pronounced in the femoral nerve. In SMA2 children the values of all tested parameters wre closer to the values of age-adjusted healthy children, nevertheless they were always below the edge of normal values, also the rate of maturation was much slower than in normal children. Sensory CV was normal children. Sensory CV was normal in all tested groups. The findings are suggestive of delayed nerve maturation in childhood SMA.


    1067/2523

    Tytuł oryginału: Suspensional reaggregates of human foetal neocortex and tegmentum as objects of neurotransplantation.
    Autorzy: Bystron Irina Pavlovna, Smirnov Eugene Borisovich, Otellin Vladimir Alexandrovich, Wierzba-Bobrowicz Teresa, Dymecki Jerzy
    Źródło: Folia Neuropathol. 2002: 40 (2) s.75-85, il., bibliogr. 25 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Suspensional reaggregates were obtained from human neocortical and tegmental anlagen (7 weeks of gestation), using 0.1 p.c. tripsin solution, and cultivated in Medium 199. Suspensional reaggregates, formed after 2 days in vitro, were grafted into the Wistar rat striatum. Incipient stages of histogenesis in the reaggregates and their interaction with host brain were investigated using light and electron microscopy, with antibodies against vimentin, glial fibrillary acidic protein (GFAP), proliferating cell nuclear antigen (PCNA), ferritin, as well as lectin ricinus communis agglutinin (RCA). The reaggregates showed a low level of tissue organistaion. An intermediate condition between suspension and the true tissue could be observed in them. These reaggregates had two evident features: a rather irregular cell arrangement (without parallel bundles of radial glia), and the presence of special intercellular junctions. Some cells made up fragments of neuroepithelial sheet in the form of true rosettes. The one-week-old grafts were integrated with the host brain as well as dissociated and contained host astrocytes. Degenerated cells and detritus appeared rarely. The data of this work let us conclude that the suspensional aggregate grafting combines some advantages of suspensional and solid grafting methods.


    1068/2523

    Tytuł oryginału: Ultrastructure of synaptic junctions in the cerebellar cortex in experimental valproate encephalopathy and after terminating chronic application of the antiepileptic.
    Autorzy: Sobaniec-Łotowska Maria E.
    Źródło: Folia Neuropathol. 2002: 40 (2) s.87-96, il., bibliogr. 44 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • badanie porównawcze
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of the study was to analyse in TEM the evolution of changes in structural elements of synaptic junctions of the cerebellar cortex in rats in valproate encephalopathy induced by chronic 12-month administration of sodium valproate - VPA (once daily intragastrically, in a dose of 200 mg/kg b.w.) and after withdrawal of this antiepileptic for 1 and 3 months. After 9 and 12 months of the experiment, synaptic endings of both the symmetrical and asymmetrical synapses in the neuropil of the cerebellar cortex, especially in the molecular layer, showed signs of sever damage (mainly swelling) and even disintegration. They were mostly observed in axodendritic endings and axospinal endings on the dendritic spines of Purkinje cells, being manifested in teh presence of large vacuolar structures, electron lucent areas and swollen mitochondria within the cytoplasm. A reduced number of axonal synaptic vesicles (with more type F vesicles preserved) could be seen. One and 3 months after the end of chronic application of VPA, the synaptic junctions did not show morphological exponents of the repair processes. The alterations observed in the synaptic junctions of the cerebellar cortex may suggest disorders in neurotransmission processes, such as exhaustion and damage caused by ischaemia due to damage to the blood-brain barrier induced by VPA and/or its toxic metabolites.


    1069/2523

    Tytuł oryginału: Studies on the pharmacokinetics of total and free valproate in mono- and bitherapy with carbamazepine in epileptic children and adolescents.
    Autorzy: Steinborn Barbara, Galas-Zgorzalewicz Bożena
    Źródło: Folia Neuropathol. 2002: 40 (2) s.97-100, tab., bibliogr. 25 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: The aim of this study was to obtain a pharmacokinetic calculation for valproic acid (VPA) and its free fraction in 50 children and adolescents (4-18 years) treated for epilepsy in VPA monotherapy and bitherapy with carbamazepine (CBZ). The diurnal fluctuation of serum concentration of total and free VPA during monotherpay was observed. The additional antiepileptic medication of VPA and CBZ was connected with prominent diurnal free VPA serum fluctuations. Pharamcokinetic parameters of total and free VPA in monotherapy were significantly different. The change of free and total VPA pharamcokinetics during bitherapy with CBZ was observed, too. No changes in half-life time of VPA in mono- and bitherpay were noticed. THe variability of pharmacokinteic parameters of free VPA suggests the need for monitoring unbound VPA plasma concentrations during bitherpay with CBZ.


    1070/2523

    Tytuł oryginału: Application of organotypic hippocampal culture for study of selective neuronal death.
    Autorzy: Sarnowska Anna
    Źródło: Folia Neuropathol. 2002: 40 (2) s.101-106, il., bibliogr. 13 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The organotypic hippocampal culture model was established according to the Stoppini method. THe transversal hippocampal slices from 7-day-old Wistar rats were cultured 14 days in vitro then subjected to acute metaboilc stress induced either by glucose deprivation or by additional treatment with a chemical respiratory chain inhibitor-cyanide in 3 mM concentration. The rate of cell death was monitored up to several hours post-treatment in living tissue by propidium iodide staining or by a trypan-blue exclusion test. No signs of selective vulnerability of any particular hippocampal region or cellular layers to applied metabolicinsults were found. Slices demonstrated total resistance even to prolonged (24 h) abscence of glucose in the culture medium, whereas the cyanide caused death which was almost immediate and unspecific to any region cells. In contrast, induction of oxidative stress by hydrogen peroxide treatment resulted in concentration and time-dependent neuronal death preferentially observed in CA1 sector of pyramidal layer. Both clinical and experimental studies confirm that the hippocampus, and particularly its CA1 sub-field, is exceptionally vunerable to ischaemic and other brain injuries. The causative role of free radical generation and the resulting oxidative stress have been widely discussed in these pathologies. Our results imply that CA1 pyramidal cells do not differe from the other hippocampal neurones in their reaction to metabolic stress. On the contrary, and from mainly unknown reasons, these CA1 neurones are extremely sensitive to the reactive oxygen-triggered damage.


    1071/2523

    Tytuł oryginału: Coexistence of diffuse large B-cell lymphoma within pontocerebellar angle schwannoma.
    Autorzy: Kolasa Paweł, Kordek Radzisław
    Źródło: Folia Neuropathol. 2002: 40 (2) s.107-110, il., bibliogr. 16 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • onkologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: We present an unusual case of diffuse large B-cell lymphoma within pontocerebellar angle shwannoma in 62-year-old woman. The patient suffered for 5 months with V, VII and VIII nerves paresis and with cerebellar ataxia. CT scan demonstrated large hyperdensive mass in cerebellopontine angle translocating cerebellar hemisphere and cerebral trunk. The patient was subjected to surgery and the tumour was removed totally by suboccipital retromastoidal right craniectomy approach. Histopathological examination revealed schwannoma infiltrated with high grade B-cell lymphoma. The patient did well following surgery without any other lymphoma manifestations, and she died from a heart attack 20 months later. Solitary lymphoma of pontocerebellar angle coexisting with schwannoma is an unusual finding, thus our case is the first report.


    1072/2523

    Tytuł oryginału: Eleven years intraoperative ATG bolus. A list of successes.
    Autorzy: Kaden Jrgen
    Źródło: Ann. Transplant. 2002: 7 (3) s.4-10, il., tab., bibliogr. 43 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Infection therapy for organ transplantation using monoclonall antibodies has been in recent years reevaluated. Results from various centers indicate the value of such therapy, especially in sensitized patients undergoing kidney transplantation as well as in simultaneous kidney - pancreas transplant patients. Author presents the experience of eleven years of intraoperative ATG bolus administration in the Berlin - Friedrichshain Kidney Transplantation Center.


    1073/2523

    Tytuł oryginału: Mechanisms of ischemic preconditioning and its application in transplantation.
    Autorzy: Kosieradzki Maciej
    Źródło: Ann. Transplant. 2002: 7 (3) s.12-20, il., bibliogr. 96 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Ischemic preconditioning is a phenomenon of increased tissue resistance to ischemic injury evoked by brirf intermittent periods of ischemia. Since its discovery in 1986, extensive studies were undertaken to explain its mechanisms and induce protection pharmacologically. There is convincing evidence on adenosine receptors., ATP-dependent potassium channels, nitric oxide and tyrosine kinases pathways involvement in the process. Universal ability of various tissues to adopt protection from short-time ischemia and reperfusion makes clinical applications of the phenomenon, including field of transplantation medicine, highly appealing. This review summarizes known physiological pathways of ischemic preconditioning. Trials on protection against cold ischemia and other transplant-related issues of preconditioning are also presented.


    1074/2523

    Tytuł oryginału: Experience with ATG short course high dose induction therapy in a series of 112 enteric drained pancreatic transplants.
    Autorzy: Bonatti H., Berger N, Kafka R., Tabbi M. G., K”nigsrainer A., Margreiter R., Steurer W.
    Źródło: Ann. Transplant. 2002: 7 (3) s.22-27, il., bibliogr. 13 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: New immunosuppressive protocols and advanced surgical technique resulted in a major improvement in the outcome of pancreatic transplantation. Patients and methods: 112 enteric drained whole pancreas transplants (PTx) performed at the Insbruck University Hospital between 3.1997 and 10.2001 were retrospectively analysed. Prophylactic immunosuppression consisted of FK506, MMF and steroids. A short course of high dose ATG induction was given additionally. Perioperative antimicrobial prophylaxis consisted of Amoxicllin/Clavulanic (32 PTx), Pipercillin/Tazobactam (68 PTx), quinolones (10 PTx) or macrolide (2 PTx). 64 patients additionally received fluconazole. Results: Actuarial patient, pancreas and kidney graft survival at one year were 96.4 p.c., 86.7 p.c. and 95.3 p.c., surgical complication rate was 28 p.c., rejection rate 40 p.c.. Eight grafts were lost due to intraabdominal infection, seven due to rejection. Median perioperative observation days (OD) were 29 (range 14-125), patients were on antibiotics for 68 p.c. of OD, and developed fever on 33 p.c. of OD. Incidence of CMV infection was 42 p.c. (bat only five patients developed CMV disease), HSV 24 p.c., intraabdominal infection 22 p.c., UTI 11 p.c., wound infection 9 p.c. and pneumonia: 5 p.c. Conclusion: ATG short course induction is well tolerated after enteric drained PTX. Infection represents a frequent and at least for IA sepsis serious complication after PTx with enteric drainage.


    1075/2523

    Tytuł oryginału: Freedom from rejection and stable kidney function are excellent criteria for steroid withdrawal in tacrolimus-treated kidney transplant recipients.
    Autorzy: Włodarczyk Z., Wałaszewski J., Perner F., Vitko S., Ostrowski M., Bachleda P., Kokot F[ranciszek], Klinger M., Szenohradsky P., Studenik P., Navratil P., Asztalos L., Rutkowski B., Nagy K. Karmar, Hickey D.
    Źródło: Ann. Transplant. 2002: 7 (3) s.28-31, il., tab., bibliogr. 5 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Objectives: This prospective, randomized, multicentre study investigated the efficacy and safety of two tacrolimus-based regimens and their potential to withdraw steroids. Methods: In total 489 patients were randomised to receive either tacrolimus and MMF (n=243) or tacrolimus and azathioprine (n=246) concomitantly with steroids in both treatment groups. The initial oral dose of tacrolimus was 0.2 mg/kg/day, MMF dose was 1 g/day, azathioprine was administered at 1-2 mg/day. Steroids were tapered from 20 mg/day to 5 mg/day. From month 3 onwards, steroids were withdrawn in patients who were free from steroid-resistant rejection and who had serum creatinine concentrations 160 ćmol/L. Study duration was 6 months. Results: Patient survival at month 6 was 98.3 p.c. (Tac/MMF/S) and 98.4 p.c. (Tac/AzaS), graft survival at 6 month was 95.0 p.c. (Tac/MMF/S) and 93.5 p.c. (Tac/Aza/S). The 6-month incidences of biopdy-proven acute rejection were 18.9 p.c. (Tac/MMF/S compared with 28.8 p.c. (Tac/Aza/S), p=0.038. The 6-month incidence of steroid-resistant acute rejection were 2.1 p.c. (Tac/MMF/S) and 4.9 p.c. (Tac/Aza/S), p=ns. At the end of month 3, steroid withdrawal was performed in 60.5 p.c. (Tac/MMF/S) and 48.8 p.c. (Tac/Aza/S) of patients, p 0.01. During months 4-6, 2.7 p.c. of patients in the Tac/MMF group had a biopsy-confirmed acute rejection compared with 0.8 p.c. of patients in the Tac/Aza group. In patients who continued to receive steroids, the incidences of biopsy-proven acute rejection during months 4-6 were 3.5 p.c. (Tac/MMF/S) and 132,8 ćmol/L (Tac/Aza/S). Conclusion: Both tacrolimus regimens are efficacious and safe. The combination of Tacrolimus and MMF achieved a lower rejection rate and permitted a higher proportion of steroid-free patients. Ther overall incidence of acute rejection was low and kidney function was good.


    1076/2523

    Tytuł oryginału: DNA from rejecting donor organs can be detected in recipient lymphoid and non-lymphoid tissues.
    Autorzy: Interewicz B., Olszewski W. L., Maksymowicz M., Stanisławska J., Szyper E.
    Źródło: Ann. Transplant. 2002: 7 (3) s.32-35, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • hematologia
  • kardiologia
  • transplantologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Rejecting tissue and organ grafts shed cellular debris from damaged cells. Cellular debris contains fragments of nuclei with their genetic material. The question arises what is the fate of donor. DNA in recipient fluids and tissues. Is it enzymatically disintegrated and becomes a waste product or it is utilized by recipient cells. We have shown, using sex-mismatched transplants and the Sry-gene fragment PCR detection method, that at the time of rejection recipient tissue contain donor DNA. The concentration of donor DNA did not paralled the concentration of live donor passenger cells. There were differences in donor DNA concentration depending on whether heart, skin or BMC were transplanted. Moreover, there was more donor DNA in recipient tissues than in control syngeneic transplants. Interestingly, a relatively, a high donor DNA concentration was detected in syngeneic recipients reflecting the extent of non-immune pre-transplantation ischemic damage of the graft.


    1077/2523

    Tytuł oryginału: Serum cytokine concentration after liver lobe harvesting for transplantation.
    Autorzy: Słotwiński R., Olszewski W. L., Paluszkiewicz R., Zieniewicz K., Hevelke P., Zaleska M., Krawczyk M., Krasnodębski I. W.
    Źródło: Ann. Transplant. 2002: 7 (3) s.36-39, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective: To investigate cytokine concentration after liver lobe harvesting for transplantation in order to prove that it is a relatively safe surgical procedure with limited tissue injury. Material and methods: Study was performed in 17 healthy liver donors and 6 patients with benign liver tumors. Serum levels of IL-6, IL-Ira and sTNFRI were measured before surgery and on the days 1, 3 and 7 thereafter, by immunoassay (ELISA). Results: There a significant increase in serum concentrations of IL-6 on day 1-7 (from 2.4 pg/ml to 315.1ń526, 47.3ń48 and 15.3ń15pg/ml; p=0.0002, p=0.0006, p=0.003), for IL-Ira on day 1-3 (from 472.5ń436 pg/ml to 2072.6ń3511 and 715.5ń268 pg/ml; p=0.001, p=0.004), and for sTNFRI on day 1-3 (from 1075.7ń338.0 pg/ml to 1601.4ń317.0 and 1528.9ń402.0 pg/ml; p=0.0006, p=0.003), following liver harvesting. No significant difference was observed between pre and postoperative IL--6 serum concentration, whereas IL-Ira and sTNFRI were elevated only on day 3 after liver resection (p=0.02, p=0.04. A significantly higher level of sTNFRI was seen in patients after liver resection, as compared to liver donors on day 1 (p=0.01), 3 (p=0.03) and 7 (p=0.0006) after surgery, whereas on day 3 (p=0.03) and 7 (p=0.0) when IL-Ira was measured. Conclusion: The short period of elevated concentrations of IL6, sTNFRI and ILIra after harvesting of lobes for transplantation and relatively low serum level of these cytokines indicate that this type of procedure does not evoke any major postoperative SIRS-type reaction as seen not infrequently after resection of liver for primary or secondary liver pathology.


    1078/2523

    Tytuł oryginału: Induction of long term peripheral microchimerism in non-human primates in a model of xenogeneic peripheral tolerance induction.
    Autorzy: Simon A. R., Schr”der C., Martin U., Tessmann R., Templin C., Laaf G., Wiebe K., Steinhoff G., Lapin B., Chikobava M., Haverich A.
    Źródło: Ann. Transplant. 2002: 7 (3) s.40-45, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • transplantologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • małpy
  • Świnie

    Streszczenie angielskie: Xenotransplantation represents a promising solution to the ever increasing shortage of donor organs in allotransplantation. However, due to different and stronger models of rejection, successful xenotransplantation will require different organ-protective regimes from those used in allogenic transplantation today. Since one can simply increase the dosage of the drugs used, immunomodulation or tolerance induction of the recipient would be the most desirable approach. Transfusion of donor leukocytes has been shown to downregulate recipient responses or even induce peripheral tolerance in small animal models. Since the infusion of donor cells represents a relatively simple approach, as one can purify and compose the inoculum exactly before infusion, we studied whether this approach can be successfully employed in a preclinical swine to nonhuman primate model of peripheral tolerance induction/immunomodulation. In our model, baboons underwent sequential column adsorption and complement blockade. The animals received only initial immunosuppression with cyclophosphamide. No further immunosuppression was given. Subsequently all animals received 1-3x10**10 porcine splenocytes i.v. Development and maintainance of chimerism was analyzed by sequential flow cytometric and PCR analyses. Other parameters studied included effects of the preparatory induction protocol. We could show that a low level of chimerism is maintained in these animals for up to 1,5 years, despite the fact that they received no additional immunosuppression after the initial one. At no time of the experiment did any animal...


    1079/2523

    Tytuł oryginału: High duodeno-jejunal anastomosis as a safe method of enteric drainage in simultaneous pancreas and kidney transplantation.
    Autorzy: Ziaja Jacek, Wullstein Christoph, Woeste Guido, Bechstein Wolf Otto
    Źródło: Ann. Transplant. 2002: 7 (3) s.46-49, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • gastroenterologia
  • transplantologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: On the key issues in successful pancreas transplantation is uncomplicated drainage of pancreas exocrine secretion. Objective: The aim of the study is to present results of side-to-side high duodeno-jejunal anastomasis as routine method of enteric drainage in simultaneous pancreas kidney transplantation (SPK). Methods: 30 diabetic patients underwent SPK at the Department of Surgery, Ruhr University Bochum in 2001. The pancreas was drained using a portion of duodenal segment anastomosed to the first loop of jejunum about 20-40 cm distal to the Treitz ligament. Results: Early relaparotomy was required in 20 p.c. patients. The mean time of the first relaparotomy was 5,5 (range 1-110 days after transplantation. In 10 p.c. cases graft pancreatectomy was necessary. Perioperative mortality was 3,3 p.c. Currently 83,3 p.c. patients are insulin-free and 86,6 p.c. patients are free of dialysis. Conclusions: These data suggest, that side-to-side high duodeno- jejunal anastomosis is a safe method of drainage of pancreas exocrine secretion in SPK.


    1080/2523

    Tytuł oryginału: Application of recombinant activated factor VII for treatment of impaired haemostasis during liver transplantation in recipients with Wilson's disease - a report of two cases.
    Autorzy: Jureczko L[idia], Trzebicki J., Zawadzki A., Pacholczyk M., Łągiewska B., Kołacz M., Szyszko G., Mayzner-Zawadzka E.
    Źródło: Ann. Transplant. 2002: 7 (3) s.52-54, tab., bibliogr. 6 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • transplantologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Recombinant activated factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S, Denmark) is a treatment used to prevent and arrest intra- and postoperative bleeding in patients with haemophilia A or B complicated by circulating anticoagulants (inhibitors of FVII and FIX) and in patients without haemophilia who spontaneously develop inhibitors of FVIII, i.e. in acquired haemophilia. Patients who qualify for liver transplantation due to liver dysfunction may have varying degrees of coagulation impairment and thus carry an elevated risk of massive bleeding and have worse prognosis. The authors administered recombinant activated factor VII to two patients with coagulation abnormalities in the couse of Wilsons's disease during liver transplantation.


    1081/2523

    Tytuł oryginału: Distribution of actin in etoposide-induced human leukemia cell line K-562 using fluorescence and immunoelectron microscopy technique.
    Autorzy: Grzanka Alina, Grzanka Dariusz
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.43-50, il., bibliogr. 26 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Localization of actin was studied in erythroleukemic cell line K-562 after treatment with etoposide for 72 hours in a range of concentration 0.02 - 200 ćM/L. Actin was visualised by fluorescence microscopy and streptavidingold method. These findings indicate that changes in actin after treatment with etoposide were dose-dependent. Significant changes in the cellular distribution of F-actin in K-562 cells were obtained after treatment with 20 and 200ćM/L etoposide. In comparison with control cells, the number of the cells decreased and cells were larger especially at 200ćM/L. F-actin was diffusely distributed throught the cell at 20ćM/L. Treatment of cells with 200ćM/L etoposide showed F-actin diffusely distributed throughout the cell with local actin assemblies and also at the cell periphery. Immunogold labelling of actin was observed in cells treated with all doses of etoposide and control cells. Labelling was found in the nucleus and also in the cytoplasm. At the ultrastructural level, cells treated with 200ćM/L etoposide showed protrusions at the surface, in which increase of actin was often observed. Etoposide causes changes in actin distribution of K-562 cells, and the changes in expression of actin were not only restricted to cell with features of apoptosis.


    1082/2523

    Tytuł oryginału: Pattern of renal á1(ŕ1 - ŕ6) integrins distribution in IgA nephropathy and Henoch-Schoenlein nephritis.
    Autorzy: Wągrowska-Danilewicz Małgorzata, Danilewicz Marian
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.51-57, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • pediatria
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Immunoperoxidase staining was carried out using monoclonal antibodies against integrins ŕ1á1, ŕ2á1, ŕ3á1, ŕ4á1 and ŕ6á1 on renal biopsy specimens from patients with IgA nephropathy (IgN, n = 15) and Henoch-Schoenlein nephritis (HSN, n = 10). The basic pattern of glomerular and tubulointerstitial (ŕ1 - á6)á1 integrin distribution was similar in both studied groups, however increase in mesangial ŕ1á1 integrin immunoexpression in biopsies from HSN patients as compared to biopsies from IgAN patients was observed. There were no statistical differences in the intensity of tubulointerstitial (ŕ1 - ŕ6)á1 integrins immunolabelling in renal tissue between IgAN and HSN patients. The similar pattern of distribution of á1 integrins in renal tissue in IgAN and HSN patients may support the hypothesis of common pathogenesis of IgAN and HSN. Upregulation of ŕ1á1 integrin on mesangial regions in biopsy specimens in patients with HSN may be connected to the much more florid glomerular changes in renal tissue in this type of glomerulonephritis than in IgAN.


    1083/2523

    Tytuł oryginału: Effect of melatonin and all-trans retinoic acid on the proliferation and induction of the apoptotic pathway in the culture of human breast cancer cell line MCF-7.
    Autorzy: Czeczuga-Semeniuk Ewa, Wołczyński Sławomir, Anchim Tomasz, Dzięcioł Janusz, Dąbrowska Milena, Pietruczuk Mirosława
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.59-65, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Melatonin in the in vitro conditions inhibits cell growth and proliferation of estrogen sensitive (ER+) cell line MCF-7 in culture. In the present study, during a 48-hour incubation melatonin at a concentration of 10-**5M inhibited [3H]thymidine incorporation into cancer cells at the level of 69.52 p.c. ń 10.99 p.c. Melatonin had no inhibitory effect on the physiological stimulatory action of estradiol. Tamoxifen added to the medium modulated the melatonin action only when the latter was added 24 hours after tamoxifen (46.45 p.c. ń 4.40, p 0.05). Tretinoin added to the culture caused a statistically significant reduction in [3H]thymidine incorporation into the cancer cells, compared to he melatonin and tretinoin groups, when treatment with retinoid was synergistic (39.05 p.c. ń 5.44, p 0.05) or sequential (tretinoin and after 24h melatonin) (39.96 p.c. ń 1.55, p 0.05). This was confirmed by immunocytochemical investigations, which showed a statistically significant reduction in the percentage of PCNA- and Ki67-positive cells. Apart from the inhibitory effect on MCF-7 cell proliferation retinoids induce the apoptotic pathway in a dose-dependent manner. Melatonin added to the culture enhances this effect, which may indicate the potential for the use of both substances in the treatment of breast cancer in women.


    1084/2523

    Tytuł oryginału: Estrogen and progesterone receptors in neoplastic and non-neoplastic thyroid lesions.
    Autorzy: Lewy-Trenda Iwona
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.67-72, tab., bibliogr. 42 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • pediatria
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The pathogenesis of thyroid cancer is complex. Iodium deficiency, genetic factors, sex, older age, irradiation in childhood, thyroid growth stimulating antibodies and epithelial growth factor possibly affect its development. Recent reports, also epidemiological, have shown that differentiated thyroid cancer (papillary, follicular, oxyphillic) is dependent on sex hormones, especially estrogens. This has prompted research into the presence of estrogens and progesterone, as well as androgen receptors (ER, PR and AR) in normal and neoplastic thyreocytes and estradiol content in thyroid tissue. The results of these investigations imply that thyroid cancer are estrogen-dependent. There is, however, no agreement in reports about correlation between tumor malignancy and ER, PR and AR expression. In this study 72 thyroid glands have been examined using immunohistochemical assays with ERs and PRs antibodies. Positive staining was demonstrated mainly in differentiated thyroid cancer nuclei (17 ERs positive and 2 PRs positive). There was no expression of antibodies in non-neoplastic cells or in adjacent tissues. The nuclei of 3 oxyphillic and 4 follicular adenomas were also ERs positive. On the other hand nuclei of 5 fokkicular adenomas were PRs positive. These results are in agreement with most available data. It seems, however, that the material so far examined by the investigators is too small. Furthermore, because of using various methods the results cannot be compared. Further studies are necessary to reveal if there is any true influence of sex hormones on the development of thyroid lesions and if the detection of sex hormone receptors may help in choosing adequate therapy.


    1085/2523

    Tytuł oryginału: Indocyanine green angiography in the diagnosis of small choroidal tumours.
    Autorzy: Kubicka-Trząska Agnieszka, Starzycka Maria, Romanowska-Dixon Bożena
    Źródło: Ophthalmologica 2002: 216 (5) s.316-319, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 300,913

    Hasła klasyfikacyjne GBL:
  • onkologia
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: To evaluate indocyanine green (ICG) angiography in the diagnosis of small choroidal tumours. Methods: We studied 40 patients with small chorodial tumours, 22 males and 18 females. The tumour thickness on ultrasonography ranged from 2.2 to 4.3 mm. Results: Nineteen pigmented tumours showed early and late diffuse hypofluorescence, consistent with naevi. Eight non-pigmented tumours showed normal choroidal vessels in calibre, configuraiton, and branching, typical of non-pigmented naevi. The early frame of ICG angiography showed in 13 cases pathological, intrinsic vascularization, suggestive of melanomas. Conclusion: This preliminary study suggests that ICG angiography may be helpful in differentiating choroidal naevi from small melanomas.


    1086/2523

    Tytuł oryginału: Treatment of neuropathic urinary and faecal incontinence.
    Autorzy: Skobejko-Włodarksa L.
    Źródło: Eur. J. Pediatr. Surg. 2002: 12 (5) s.318-321, il., tab., bibliogr. 10 poz., Zsfg, r‚s., res.
    Sygnatura GBL: 312,942

    Hasła klasyfikacyjne GBL:
  • neurologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: The author presents 14 children after meningomyelocoele repair with faecal and urinary incontinence, aged from 6 to 17 years who have undergone the MACE procedure. MACE with synchromous Mitrofanoff continent stoma creation was performed in one child with severe steniosis of the urethra. MACE with simultaneous bladder augmentation was used in 10 patients. 5 of them underwent colocystoplasty, 3 had ileocystoplasty and 2 ureterocystoplasty. Of these 10 children, three have additionally undergone the Mitrofanoff procedure. patients' follow-up ranged from six months to two years. Three children had trouble with the MACE stoma because of its stenosis. One of them required revision of the stoma. All patients became clean and dry, and this operation improved not only their quality of life, but also their independence.


    1087/2523

    Tytuł oryginału: Transabdominal ultrasound for visualizing gastric submucosal tumors diagnosed by endosonography: can surveillance be simplified?
    Autorzy: Polkowski M., Palucki J., Butruk E.
    Źródło: Endoscopy 2002: 34 (12) s.979-983, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 305,439

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background an study aims: Management options for gastric submucosal tumors (SMTs) include tumor removal or surveilance. If the latter is chosen, it requires repeated measurements of the tumor diameter. Although this can be achieved using endoscopy or endosonography (EUS), a less invasive and cheaper method would be welcome. THe aim of this prospective study was to assess the proportion of gastric SMTs that can be visualized using transabdominal ultrasound of the water-filled stomach. Patients and methods: Fifty-one consecutive patients with endosonographically diagnosed gastric SMTs underwent transabdominal ultrasound examinations of the water-filled stomach performed immediately after EUS; both procedures were carried out by the same investigator. Transabdominal ultrasound was considered positive only if: firstly, the tumor was visualized unequivocally; secondly, its dimensions could be measured; and thirdly, photographic documentation could be recorded. In each case, a positive result had to be confirmed by an independent in vestigator, who reviewed the photographic documentation. Results: The median size of SMTs on EUS was 25 mm (range 4-55 mm). Twelve tumors were located in the antrum, 25 in the gastric body, and 14 in the gastric fundus or cardia. Transabdominal ultrasound demonstrated the tumor in 35 of 51 patients (69 p.c.). For tumors ó 30 mm, the visualization rate was 61 p.c. (22 of 36). The location of the tumor and its EUS features did not significantly affect the sensitivity of transbdominal ultrasound. Conclusions:...


    1088/2523

    Tytuł oryginału: Primenenie videotorakoskopii v khirurgicheskom lechenii miastenii.
    Tytuł angielski: Application of videothoracoscopy in surgical treatment of myasthenia.
    Autorzy: Peljukhovskij S. V.
    Źródło: Klin. Khir. 2002 (8) s.23-24, bibliogr. 11 poz., sum.
    Sygnatura GBL: 303,753

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In 39 patients with various forms of myasthenia operation thymectomy was performed, including those 9 (20.5 p.c.), to whom it was done using method of videothoracoscopy. There were no postoperative complications. Good cosmetic effect was noted, the duration of hospital treatment of the patietns had reduced more than twice, causing economic effect.


    1089/2523

    Tytuł oryginału: B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity.
    Autorzy: Tsuji Ryohei F., Szczepanik Marian, Kawikova Ivana, Paliwal Vipin, Campos Regis A., Itakura Atsuko, Akahira-Azuma Moe, Baumgarth Nicole, Herzenberg Leonore A., Askenase Philip W.
    Źródło: J. Exp. Med. 2002: 196 (10) s.1277-1290, il., bibliogr. 59 poz.
    Sygnatura GBL: 310,177

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Contact sensitivity (CS) is a classic example of in vivo T cell immunity in which skin sensitization with reactive hapten leads to immunized T cells, which are then recruited locally to mediate antigen-specific inflammation after subsequent skin challenge. We have previously shown that T cell recruitment in CS is triggered by local activation of complement, which generates C5a that triggers C5a receptors most likely on mast cells. Here, we show that B-1 cell-derived antihapten IgM antibodies generated within 1 day (d) immunization combine with local challenge antigen to activate complement to recruit the T cells. These findins overturn three widely accepted immune response paradigms by showing that (a) specific IgM antibodies are required to initiate CS, which is a classical model of T cell immunity thought exlusively due to T cells, (b) CS priming induces production of specific IgM antibodies within 1 d, although primary antibody responses typically begin by day 4, and (c) B-1 cells produce the 1-d IgM response to CS priming, although these cells generally are thought to be nonresponsive to antigenic stimulation. Coupled with previous evidence, our findings indicate that the elicitation of CS is initiated by rapidly formed IgM antibodies. The IgM and challenge antigen likely form local complexes that activite complement, generating C5a, leading to local vascular activation to recruit the antigen-primed effector T cells that mediate the CS response.


    1090/2523

    Tytuł oryginału: Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells.
    Autorzy: Błasiak Janusz, Gloc Ewa, Młynarski Wojciech, Drzewoski Józef, Skórski Tomasz
    Źródło: Leuk. Res. 2002: 26 (12) s.1093-1096, il., bibliogr. 8 poz.
    Sygnatura GBL: 306,151

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • genetyka
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Human lymphocytes, p53 protein-deficient acute promyelocytic leukemia cell line HL-60, murine pro-B lymphoid cell line BaF3 and its TEL/ABL-transformed clone cells were exposed to idarubicin with and without pre-treatment with amifostine. Idarubicin at 0.5 - 5ćM evoked DNA damage measured by the Comet assay. Amifostine at 14 mM decreased DNA-damaging effect of idarubicin in human lymphocytes and BaF3 cells, but increased the effect in TEL/ABL-transformed cells. Amifostine had no influence on the action of idarubicin in HL-60 cells. Our results suggest that the reaction of the cell to DNA damage may contribute to its diverse response to amifostine combined with anticancer drugs and that p53 and fusion tyrosine kkinases may be involved in this diveristy.


    1091/2523

    Tytuł oryginału: European Society of Cardiology Congress 31 August - 4 September 2001, Berlin - Germany: abstracts.
    Źródło: Eur. Heart J. 2002: 23 supl. s.I-XVI, 1-791, il., tab. - Kongres Europejskiego Towarzystwa Kardiologicznego Berlin 31.08-04.09. 2002
    Sygnatura GBL: 306,213

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Europejskie Towarzystwo Kardiologiczne


    1092/2523

    Tytuł oryginału: Karol Marcinkowski University of Medical Science, Poznań Faculty of Medicine Division of Dentistry : course credit transfer system : information package 2001/2002
    Opracowanie edytorskie: Przystanowicz Aleksander (ed.), Rębała Leszek (ed.), Shaw Geoffrey (ed.).
    Źródło: - Poznań, Dział Wydaw. Uczelnianych AM 2002, 73, [1] s., [3] k. tabl. : il., tab., 31 cm.
    Sygnatura GBL: 802,193

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • informator
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Akademia Medyczna w Poznaniu


    1093/2523

    Tytuł oryginału: Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 1: Alterations of myelinated axons.
    Autorzy: Liberski Paweł P., Bratosiewicz-Wąsik Jolanta, Gajdusek D. Carleton, Brown Paul
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.121-129, il., bibliogr. s. 127-129
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki

    Streszczenie angielskie: Classical and ultrastructural neuropathology of prion diseases are generally well described. Here we report that alternations of myelinated fibres in hamsters infected either with polioencephalopathic strains of scrapie or panencephalopathic strains of CJD (Echigo-1) are virtually identical and differ only quantitatively. In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres.


    1094/2523

    Tytuł oryginału: Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 2: Astrocytic and macrophage reaction towards axonal destruction.
    Autorzy: Liberski Paweł P., Bratosiewicz-Wąsik Jolanta, Gajdusek D. Carleton, Brown Paul
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.131-139, il., bibliogr. s. 137-139
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki
  • Świnki morskie

    Streszczenie angielskie: We report hare the microglial (macrophage) and astrocytic reaction in several models of transmissible spongiform encephalopathies (TSEs) or prion diseases. With the low power electron microscopy it was readily apparent that myelinated vacuoles were surrounded by cells and their processes. The latter belonged either to hyperplastic reactive astrocytes or to macrophages. Typically, reactive astrocytes exhibited cytoplasm filled with innumerable glial filaments and, occasionally, other organelles (like cilia) and abundant tortuous intercellular junctions of adhesive plaque junction type. Desmosome-like junctions connecting astrocytic elements were also seen. As described earlier, astrocytic process were occasionally interdigitated with oligodendroglial cells and their processes. Two types of macrophages were readily described. The majority of them exhibited electron-dense cytoplasm and numerous "empty" vacuoles (digestive chambers) containing cellular debris. Occasional vacuoles were surrounded by a thin collar reminiscent of "lyre-like inclusions" of the second type of macrophages. Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae.


    1095/2523

    Tytuł oryginału: How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited.
    Autorzy: Liberski Paweł P., Gajdusek D. Carleton, Brown Paul
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.141-147, il., bibliogr. s. 145-147
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki

    Streszczenie angielskie: As in other neurodegenerative diseases such as Alzheimer's disease, neurons in prion diseases or transmisible spongiform encephalopathies (TSEs) die via programmed cell death of which the apoptotic process is relatively well characterized. A subcellular alteration linked to apoptosis is the formation of autophagic vacuoles, which we and others demonstrated in CJD- and scrapie-affected rodent brains. Autophagy may co-exist with apoptosis or may precede it and the process may be induced by apoptosis stimuli. Here, we extend these observations using different model of scrapie and CJD. Both scrapie models (the 265K and 22C-H) demonstrated autophagic vacuoles with the same frequency; hence, they will be described together. While the following changes had been observed simultaneously in different areas of the same sample, this description is organised as if it followed a sequence of events. First, a part of the neuronal cytoplasm was sequestrated by concentric arrays of membrane; that part of the cytoplasm closed by membranes appeared relatively normal but its density often appeared increased. Next, electron density of the central dramatically increased. Then, membranes proliferated within the cytoplasm in a labyrinth-like manner and an area sequestrated by these membranes enlarged and became more complex structure consisting of vacuoles, electron-dense area and areas of normally-looking cytoplasm connected with convoluted membranes. Finally, a large area of the cytoplasm was transformed into a collection of autophagic vascuoles of different sizes. Virtually identical alternations, albeit with much lower frequency, were seen in terminally ill CJD-affected hansters.


    1096/2523

    Tytuł oryginału: Codon 219 in Creutzfeld-Jakob disease in Poland.
    Autorzy: Bratosiewicz-Wąsik Jolanta, Wąsik Tomasz J., Liberski Paweł P.
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.149-151, il., bibliogr. s. 151
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • komunikat

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Prion diseases are a group of etiologically heterogenous diseases. In addition to familial cases linked to mutations of PRNP open reading frame they include also cases of unknown etiology. One of the susceptibility factors to sporadic as well as iatrogenic prion diseases are PRNP polymorphisms. In the present study, we analyzed sequences of the PRNP gene codon 219 of 16 Polish CJD cases and we found heterozygous GAG to GAT changes on the sense strand and only wild type sequences on an antisense strand. The RFLP technique was used to verify this divergence and only wild type sequences were revealed.


    1097/2523

    Tytuł oryginału: Molecular biology of prions.
    Autorzy: Weissmann Charles, Enari Masato, Kl”hn Peter Christian, Rossi Daniela, Flechsig Eckhard
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.153-166, il., tab., bibliogr. [111] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in they are transmissible, not only experimentally but also by natural routes, mainly by ingestion. The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistence to conventional sterilisation procedures, and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals in cell culture.


    1098/2523

    Tytuł oryginału: Variant Creutzfeldt-Jakob disease.
    Autorzy: Will Robert George
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.167-173, il., tab., bibliogr. [18] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Variant Crutzfeldt-Jakob disease is caused by the transmission of bovine spongiform encephalopathy to humans. The clinical and investigative features of variant CJD are relatively distinct from sporadic CDJ. The number of cases of vCJD are increasing with time in the UK, but the total future number of cases of vCJD is uncertain.


    1099/2523

    Tytuł oryginału: Neuropathology of variant Creutzfeldt-Jakob disease.
    Autorzy: Ironside James W., Head Mark W., McCardle Linda, Knight Richard
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.175-182, il., tab., bibliogr. s. 181-182
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The clinical, neuropathological genetic and biochemical features of variant Creutzfeldt-Jakob disease (vCJD) are compared to the 926 other cases of suspected CJD referred to the National CJD Surveillance Unit laboratory from 1999 - 2001. Histological studies of the central nervous system, lymphoid tissues and other organs were accompanied by immunocytochemistry for prion protein (PrP); Western blot analysis of PrP**RES was performed on frozen brain tissue. The pathology of vCJD showed relatively uniform morphological and immunocytochemical characteristics, with PrP accumulation in lymphoid tissues, but not in other non-neural tissues. PrP**RES accumulation in vCJD showed a uniform glycotype pattern distinct from sporadic CJD. All cases of vCJD were methionine homozygotes at codon 129 of the PrP gene. In view of the spread of bovine spongiform encephalopathy in Europe and Japan, continuing surveillance is required for all forms of CJD, with histological and biochemical analysis of suspected cases to allow an accurate laboratory diagnosis.


    1100/2523

    Tytuł oryginału: Bovine spongiform encephalopathy. Update.
    Autorzy: Bradley Ray
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.183-195, il., tab., bibliogr. [24] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia
  • weterynaria

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło
  • koty

    Streszczenie angielskie: Bovine spongiform encephalopathy (BSE) is a zoonosis being the origin of variant Creutzfeldt-Jakob disease and an important cattle in its own right. Countries have been slow to learn the importance of protecting, not only their cattle populations, but also their human populations. Since 2000, several additional European countries have reported BSE in native-born stock and this has led to a concern about the BSE status of countries that have imported cattle and cattle products from infected countries. Extensive feed and offal bans and application of newly-developed, 'Rapid' tests for prion protein in central nervous tissue of targeted, high-risk animals and slaughter cattle over 30 months old now provides the tools whereby the public are fully protected and BSE can be eradicated.


    1101/2523

    Tytuł oryginału: Prion diseases: a dual view of the prion hypothesis as seen from a distance.
    Autorzy: Liberski Paweł P., Jaskólski Mariusz
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.197-226, il., tab., bibliogr. [269] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: We review the historical background and principles of the prion theory in its current shape. We showed that most of data may be still interpreted dually according to the protein only hypothesis and according to the theory in which additional component is necessary to comprise the infectivity. The enormous impact of structural biological studies is also stressed.


    1102/2523

    Tytuł oryginału: Plasma tissue inhibitor of metalloproteinases-1 and transforming growth factor á1 - possible non-invasive biomarkers of hepatic fibrosis in patients with chronic B and C hepatitis.
    Autorzy: Flisiak Robert, Maxwell Paul, Prokopowicz Danuta, Timms Peter M., Panasiuk Anatol
    Źródło: Hepatogastroenterology 2002: 49 (47) s.1369-1372, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 304,355

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background/Aims: The role of transforming growth factor-á1 (TGF-á1) in liver fibrosis is in part related to impairment of extracellular matrix breakdown by stimulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) gene. The aim of he study was to evaluate association between TGF-á1 and TIMP-1 in relation to liver injury in chronic viral hepatitis N and C. Methodology: Association between plasma TGF-á1 and TIMP-1 was evaluated in 28 consecutive patients undergoing kiver biopsy for chronic viral hepatitis B and C (CH-B, CH-C) and these tests were correlated with hepatic fibrosis, inflammation and liver function tests. Moreover carboxyterminal cross-linked telopeptide of type 1 procollagen (ICTP) and carboxyterminal propeptide of type 1 collagen (PICP) were also measured for assessment of extracellular matrix breakdown or synthesis, respectively. Results: Chronic viral hepatitis B and C resulted in a significant increase in plasma TIMP-1 levels but not TGF-á1. Among biochemical markers of liver injury, significant correlation with TGF-á1 and TIMP-1 was demonstrated in respect to aminotransferase activities in both groups. TIMP-1 showed significant correlation with ICTP levels in both CH-B (r = 0.59) and CH-C (r = 0.62), whereas TGF-á1 was correlated with ICTP only in CH-C patients (r = 0.75). PICP did not demonstrate any corelation with either TGF-á1 or TIMP-1. Hepatic fibrosis, but not inflammation, correlated significantly with TGF-á1 (CH-B: r = 0.73; CH-C: r = 0.79) and TIMP-1 (CH-B: r = 0.66; CH-C r = 0.71) in both groups and there was a significant...


    1103/2523

    Tytuł oryginału: Complexed prostate-specific antigen, complexed prostate-specific antigen of total and transition zone, complexed/total prostate-specific antigen ratio, free-to-total prostate-specific antigen ratio, density of total and transition zone prostate-specific antigen: results of the prospective multicenter european trial.
    Autorzy: Djavan Bob, Remzi Mesut, Zlotta Alexandre R., Ravery Vincent, Hammerer Peter, Reissigl Andreas, Dobroński Piotr, Kaisary Amir, Marberger Michael
    Źródło: Urology 2002: 60 (4a) suppl. s.4-9, tab., bibliogr. 30 poz.
    Sygnatura GBL: 312,634

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: This prospective, multicenter European Prostate Cancer Detection study evaluated the value and performance of the molecular forms of prostate-specific antigen (PSA) and their derivatives in combinantion with prostate gland and transition zone volumes in early detection of prostate cancer in patients with PSA levels between 4 and 10 ng/mL. Of 750 men enrolled at 7 different European urology centers into the study between November 2001 and March 2002, 340 (45.3 p.c.) had a total PSA (tPSA) between 4 and 10 ng/mL (age range, 46 to 87 years). In all patients, the ratio of complexed PSA (cPSA) to tPSA (c/tPSA), cPSA density (cPSAD), cPSAD of the transition zone, PSA, free (fPSA), ratio of fPSA to tPSA (f/tPSA), tPSA density (PSAD), and PSAD of the transition zone were measured and collected 5 to 10 minutes before the sextant biopsy with 2 additional transition zone cores. Measurements of tPSA and fPSA were done with the AxSYM test, whereas cPSA was measured with the ACS 180 cPSA assay. All patients had a transrectal ultrasound-guided sextant prostate biopsy, and 2 additional transition zone bipsies and total and transition zone volumes were measured at the time of biopsy. Histopathologic findings revealed benign in 237 patients and prostate cancer in 103 patients (69.7 p.c. and 30.3 p.c., respectively). Statistically significant differences included larger total volumes, larger transition zone volumes, and f/tPSA in patients with benign disease (P = 0.0009, P 0.0001, P 0.0001, respectively). At 90 p.c. and 95 p.c. sensitivity, specificity of cPSA was significantly...


    1104/2523

    Tytuł oryginału: DNA microarrays - a methodological breakthrough in genetics.
    Autorzy: Kamiński Stanisław
    Źródło: J. Appl. Genet. 2002: 43 (2) s.123-130, il., bibliogr. [18] poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny


    1105/2523

    Tytuł oryginału: Journal of Applied Genetics
    Tytuł angielski: Novel linkage mapping approach using DNA pooling in human and animal genetics. [P.] 1: Detection of complex disease loci.
    Autorzy: Pareek Chandra S., Pareek Ravi S., Walawski Krzysztof
    Źródło: J. Appl. Genet. 2002: 43 (2) s.175-192, il., tab., bibliogr. [48] poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: DNA pooling is a potential methodology for genetic loci with small effect contributing rapid preliminary screening of the genome for the allelic association with the most common class of polymorphic short tandem repeart markers. The methodology assumes as a common founder for the linked disease locus of interest and searches for a region of a chromosome sheared between affected individuals. The general theory of DNA pooling basically relies on the observed differences in the alletic distribution between pools from affected and unaffected individuals, including a reduction in the number of alleles in the affected pool, which indicate the sharing of a chromosomal region. The power od statistic for associated linkage mapping can be determined using two recently developed strategies, firstly, by measuring the differences of allelic image patterns produced by two DNA pools of extreme character and secondly, by measuring total allele content differences by comparing between two pools containing large numbers of DNA samples. These strategies have effectively been utilized to identify the shared chromosomal regions for linkage studies and to investigate the candidate disease locci for fine structure gene mapping using allelic association. This paper outlines the utilization of DNA pooling as a patential tool to locate the complex disease loci, statistical methods for accurate estimates of allelic frequencies from DNA pools, its advantagess, drawbacks and significance in associate linkage mapping using pooled DNA samples.


    1106/2523

    Tytuł oryginału: Clinical features, treatment and genetic background of Treacher Collins syndrome.
    Autorzy: Marszałek Bożena, Wójcicki Piotr, Kobus Kazimierz, Trzeciak Wiesław H.
    Źródło: J. Appl. Genet. 2002: 43 (2) s.223-233, il., tab., bibliogr. [24] poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Treacher Collins syndrome (TCS) is an autosomal dominant disorder of craniofacial development. The major features of the disease include midface hypoplasia, micrognathia, microtia, conductive hearing loss and cleft palate. Current procedures of surgical treatment of TCS are discussed and novel findings concerning the genetic backgroung of TCS are described. The TCS locus has been mapped to chromosome 5q31.3-32. The TCOFI gene contains 26 exons and encodes a 1411 amino acid protein named treacle. In the TCOFI gene 51 mutations have been identified. Most of these mutations are insertions or deletions, which result in an introduction of a premature terminantion codon into the reading frame. Mutational spectra support the hypothesis that TCS results from haploinsufficiency of treacle.


    1107/2523

    Tytuł oryginału: Fluctuactions of gastrin. Motilin and total bile acid levels in porcine blood before and after feeding.
    Tytuł polski: Zmienność poziomu gastryny, motyliny i kwasów żółciowych w surowicy świń przed i po karmieniu.
    Autorzy: Romański Krzysztof W., Salomon Ewa, Borodulin-Nadzieja Ludmiła, Janocha Anna
    Źródło: Folia Med. Crac. 2002: 43 (1/2) s.5-12, tab., bibliogr. 42 poz., streszcz.
    Sygnatura GBL: 304,697

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie polskie: U czterech młodych, zdrowych świń wykonywano radioimmunologiczne badania poziomu gastryny w surowicy, motyliny w osoczu oraz poziomu sumy kwasów żółciowych w surowicy krwi w ciągu czterech godzin okresu międzytrawiennego oraz w okresie do jednej godziny po zastoswaniu standardowej procedury karmienia. U zwierząt głodzonych 24 godziny, stężenia gastryny, motyliny i kwasów żółciowych wykazywały oscylacje i czas trwania okresów oscylacji był podobny do czasu trwania cyklu motorycznego w okresie międzytrawiennym. Jednakże tylko piki poziomu motyliny były czasowo skorelowane z pikami poziomu kwasów żółciowych. Karmienie nie znosiło oscylacji poziomu motyliny i kwasów żółciowych oraz istotnie obniżało poziom kwasów żółciowych w surowicy. Zatem współzależność pomiędzy poziomami gastryny, motyliny i kwasów żółćiowych różnią się częściowo u świń od tych u człowieka i psa; ponadto pozostaje szereg niejasności odnośnie regulacyjnej roli obu badanych hormonów, zwłaszcza w okresie poposiłkowym.

    Streszczenie angielskie: In four yount healthy pigs, the radioimmunological determinations of serum gastrin, plasma motilin and total serum bile acids were performed during four hours of the interdigestive state and up to one hour after standard feeding procedure. In 24-hr fasted animals, gastrin, motilin and bile acid concentrations fluctuated and duration of oscillation periods was similar to the length of the interdigestive motor cycle. However only motilin peaks were temporally correlated with bile acid peaks. Feeding did not abolish motilin and bile acid fluctuations and significantly decreased serum bile acid level. It is concluded that the relationships among gastrin, motilin and bile acids are in part different in pigs from those in man and dog and still some controversy exists as to the regulatory role of both hormones mainly in the postprandial state.


    1108/2523

    Tytuł oryginału: Interdigestive contractions of the gallbladder in rabbits: the real time ultrasonographical studies.
    Tytuł polski: Skurcze międzytrawienne pęcherzyka żółciowego u królików. Badanie USG.
    Autorzy: Romański Krzysztof W., Woźniak-Stolarska Barbara
    Źródło: Folia Med. Crac. 2002: 43 (1/2) s.13-20, tab., bibliogr. 32 poz., streszcz.
    Sygnatura GBL: 304,697

    Hasła klasyfikacyjne GBL:
  • radiologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie polskie: Brak doniesień dotyczących ultrasonograficznego badania kurczliwości pęcherzyka żółciowego u królika. Zatem celem obecnych badań była ocena dynamiki skurczów pęcherzyka żółciowego u 7 królików. Zwierzęta karmiono 24 godziny przed doświadczeniami, które trwały 3-5 godzin. Badania ultrasonograficzne przeprowadzano co 10 minut używając aparatu typu USG 220 SLC. Sektorową sondę 3,5 MHz przykładano w rejonie prawego podżebrza. Uzyskiwano maksymalne podłużne obrazy pęcherzyka żółciowego i szacowano objętość pęcherzyka żółciowego stosując 3 metody. Najwyższe wartości otrzymano dzięki użyciu emtody przybliżającej kształt pęcherzyka żółciowego do elipsoidy. Stosując metodę przybliżania kształtu pęcherzyka żółciowego do beczki otrzymano wyniki pośrednie, a najniższe wartości otrzymano metodą sumy cylindrów. Wartość średnia wszystkich objętości pęcherzyka żółciowego uzyskanych ostatnią metodą wynosiła 1,34 ń 0,10 ml. Wartości szczytowe i międzyszczytowe wynosiły odpowiednio 2,23 ń 0,33 i 0,99 ń 0,18 ml. Średnia odległość pomiędzy pikami wynosiła 69,6 ń 7,4 min pozostając w przybliżeniu zgodną z opisaną w piśmiennictwie długością cykli MMC u królika. Wyniki sugerują, że model ultrasonografii pęcherzyka żółciowego królika może być ogólnie użyteczny w badaniach dynamiki pęcherzyka żółciowego.

    Streszczenie angielskie: There are no reports concerning the ultrasonographical examination of gallbladder contractility in rabbits. Thus, the aim of this study was to assess the dynamics of gallbladder contractions in 7 rabbits. Animals were fasted 24 h before the experiments lasting 3-5 h. Ultrasonographical examinations were performed every 10 min using USG 220 SLC machine. The sectorial ultrasound 3.5 MHz was placed in the right subcostal region. The maximal longitudinal gallbladder scans were obtained and the gallbladder volume was estimated using 3 methods. The highest values were obtained with the method approximating the gallbladder shape to ellipsoid. The second method approximating gallbladder shape to the barrel provided intermediate results and the lowest results were obtained with the sum-of-cylinders method. The overall mean of interdigestive gallbladder volume using the latter method was 1.34 ń 0.10 ml. Peak and interpeak values were 2.23 ń 0.33 and 0.99 ń 0.18 ml, respectively, p 0.01. The mean peak distance was 69.6 ń 7.4 min approximately remaining in concert with the reported MMC intervals in rabbits. It is concluded that the rabbit model for gallbladder ultrasonography may be useful for the study of gallbladder dynamics.


    1109/2523

    Tytuł oryginału: The usefulness of low-pressure pneumoperitoneum in laparoscopic surgery.
    Tytuł polski: Przydatność techniki odmy niskociśnieniowej w chirurgii laparoskopowej.
    Autorzy: Barczyński Marcin, Herman Roman Maria
    Źródło: Folia Med. Crac. 2002: 43 (1/2) s.43-50, tab., bibliogr. 50 poz., streszcz.
    Sygnatura GBL: 304,697

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy była ocena przydatności techniki odmy niskociśnieniowej (ON) w chirurgii laparoskopowej. Grupę kolejnych 152 chorych z objawową niepowikłaną kamicą pęcherzyka żółciowego zakwalifikowanych do zabiegu cholecystektomii laparoskopowej (LC) przeanalizowano co do możliwości wykonania zabiegu w technice ON. Zastosowano następujące kryteria wyłączenia: BMI 27 oraz laparotomia w wywiadzie. Spośród 152 chorych jedynie 82 (53,9 proc.) chorych spełniających kryteria włączenia do bdania zakwalifikowano do zabiegu w technice ON (73 kobiety i 9 mężczyzn). BMI wynosił średnio 25,23 ń 1,4; średni wiek wynosił 46 ń 7,8 lat. Odmę otrzewnową wytwarzano za pomocą igły Veressa do ciśnienia 12 mmHg, a pierwszy troakar TERNAMIAN-EndoTip zakładano od kontrolą optyki. Po wkłuciu pozostałych troakarów roboczych, ciśnienie odmy otrzewnowej obniżano do 7 mmHg. W czasie zabiegu operacyjengo monitorowano chorych kapnograficnzie. Spośród 82 chorych włączonych do badania LC w technice ON wykonano z powodzeniem u 73 chorych (89 proc.). U 8 (9,75 proc.) chorych (wszyscy byli płci męskiej, a 3 miało ponad 55 lat) ciśnienie odmy otrzewnowej zwiększono do 15 mmHg z uwagi na długość pęcherzyka żółciowego przekraczającą 12 cm i niewystarczającą ekspozycję okolicy trójkąta Calota. u 1 chorego (1.22 proc.) wykonano konwersję do laparotomii z powodu trudności w identyfikacji struktur anatomicznych w obrębie trójkąta Calota. LC może być wykonana w technice ON u większości pacjentów z BMI 27, ...

    Streszczenie angielskie: The aim of the study was to assess the usefulness of low-pressure pneumopertoneum (LP) in laparoscopic surgery. A consecutive group of 152 patietns qualified for laparoscopic cholecystectomy (LC) was assessed as to the possibility of performing the procedure with LP 7 mmHg. The following exclusion criteria were used: Body Mas Index (BMI) 27 and laparotomy in medical history. The subsequent stage of the trial included 82 (53.9 p.c.) patietns (73 females, 9 males) meeting the inclusion criteria. The mean BMI was 25.23 ń 1.4; mean age was 46 ń 7.8 years. All the patietns suffered from symptomatic uncomplicated gallstones confirmed in ultrasound. The pneumoperitoenum was created in a blind way with a Veress needle up to pressure of 12 mmHg and the first 10mm TERNAMIAN-EndoTip trocar was introduced under direct visual control. After the placement of other trocars, the working pressure was reduced from 12mmHg to 7mmHg. The pCO2 concentration was monitored intraoperatively by a capnometer. Among 82 patients included into the study the LPLC was successfully performed in 73 (89 p.c.) patietns. In 8 (9.75 p.c.) patietns the working pressure had to be increased to 15 mmHg due to the gallbladder exceeding 12cm in length and difficulties in its proper mobilization required to visualize the neck of the gallbladder. All these patietns were male and 3 of them were 55 years of age or more. In 1 (1.22 p.c.) patient conversion was necessary because of difficulties in identification ...


    1110/2523

    Tytuł oryginału: Influence of different pressures of pneumoperitoneum on the autonomic system function during laparoscopy.
    Tytuł polski: Wpływ ciśnienia odmy otrzewnowej na czynność autonomicznego układu nerwowego w trakcie laparoskopii.
    Autorzy: Barczyński Marcin, Herman Roman Maria
    Źródło: Folia Med. Crac. 2002: 43 (1/2) s.51-58, tab., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 304,697

    Hasła klasyfikacyjne GBL:
  • neurologia
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wpływ ciśnienia odmy otrzewnowej na aktywność autonomicznego układu nerwowego (AUN) nie była dotychczas szczegółowo analizowana. Do prospektywnego badania włączono 20 chorych zakwalifikowanych do cholecystektomiii laparoskopowej. Zrandomizowano ich do dwóch 10-osobowych grup: odmy niskociśnieniowej (LP = 7 mmHg) i odmy standardowej (SP = 12 mmHg). Wprowadzenie do znieczulenia ogólnego uzyskiwano fentanylem i thiopenthalem, które podtrzymywano isofluranem. Wentylację kontrolowano mechanicznie (18 oddechów na minutę, końcowowydechowa prężność CO2 30-35 mmHg, ciągłe monitorowanie kapnograficzne). Ciśnienie odmy otrzewnowej utrzymywano za pomocą automatycznego insuflatora Co2. Pacjenci byli utrzymywani w pozycji leżącej w czasie całego badania. Czynność AUN oceniano za pomocą analizy zmienności rytmu serca (HRV), wykonując śródoperacyjnie 3 pomiary po 5 minut: przed wprowadzeniem do znieczulenia, po wprowadzeniu i po wytworzeniu odmy otrzewnowej. W ocenie HRV wykorzystano analizę widmową niskich (LF = 0,05 - 0,15 Hz) i wysokich (HF = 0,15 - 0,45 Hz) komponent częstotliwości za pomocą szybkiej transformacji Fourierowskiej. Przeprowadzono anlizę statystyczną uzyskanych wyników. Składowa LF uległa obniżeniu po wprowadzeniu do znieczulenia a zwiększyła się po wytworzeniu odmy w obu grupach (p 0,01). LP w mniejszym stopniu aktywowała AUN niż SP (LF: 68,12 ń 6,56 nu vs. 78,26 ń 5,43 nu, p 0,01; HF: 24 ń 3,48 vs. 15.56 ń 2,54 nu, p 0,05). Reasumując, wytworzenie odmy ...

    Streszczenie angielskie: The effects of different pressure values of pneumoperitoneum on the activity of the autonomic nervous system (ANS) have not been investigated in detail. In this prospective study, 20 patietns qualified for laparoscopic cholecystectomy were randomised to either low-pressure (LP = 7 mmHg) or standard-pressure (SP = 12 mmHg) pneumoperitoneum groups, 10 patients each. The anesthesia was induced with fentanyl and thiopental and maintained with isoflurane. Ventilation was mechanically controlled (18 breaths per minute, end-tidal CO2 30-35 mmHg, instant capnometer monitoring). Intraabdominal pressure was maintained automatically by a CO2 insufflator. Patient were kept in a horizontal position. The ANS was evaluated by heart rate variability (HRV) analysis (POSTER ECG 2002 System) measured intraoperatively in three recordings of 5 minutes each: in awake patient, after induction of general anesthesia, and after creation of pneumoperitoneum. Power spectral analysis of HRV was applied, the low-frequency (LF = 0.05 - 0.15 Hz) and high frequency (HF - 0.15 - 0.45 Hz) spectral density of the HRV were analysed using the Fast Forier Transform algorithm. The appropriate statistical analysis of data was performed. LF density decreased at the anesthetized stage and increased at the insufflated stage in both groups (p 0.01). LP resulted in lower sympathetic activation than SP pneumoperitoneum (LF: 68.12 ń 6.56 nu vs. 78.26 ń 5.43 nu, p 0.01; HF: 24 ń 3.48 nu vs. 15.56 ń 2.54 nu, p ...


    1111/2523

    Tytuł oryginału: Various patterns of oral mucosa candidiasis treatment in HIV patients.
    Tytuł polski: Sposoby leczenia kandydozy błony śluzowej jamy ustnej u chorych zakażonych HIV.
    Autorzy: Macura Anna B., Bort Artur, Postawa-Kłosińska Barbara, Mach Tomasz
    Źródło: Folia Med. Crac. 2002: 43 (1/2) s.69-77, il., tab., bibliogr. 19 poz., sum.
    Sygnatura GBL: 304,697

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • aIDS
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Jama ustna jest miejscem występowani różnych objawów u chorych zakażonych wirusem HIV. Jednym z najczęstszych jest kandydoza jamy ustnej. Może ona być pierwszym objawem choroby podstawowej. Długotrwała obserwacja wykazała, że leczenie antyretrowirusowe jest korzystne również w odniesieniu do tego oportunistycznego zakażenia, ponieważ zmniejsza zarówno liczbę nawrotów, jak i ich nasilenie. Jednakże przedłużenie czasu przeżycia pacjentów stwarza konieczność również przedłużenia leczenia przeciwgrzybiczego a także obserwacji jego skuteczności i stosowanych metod. Celem pracy była ocena wpływu leczenia antyretrowirusowego co najmniej trzema lekami na występowanie kandydozy jamy ustnej u chorych leczonych w oddziale szpitalnym lub Regionalnej Przychodni HIV/AIDS przy Katedrze i Klinice Chorób Zakaźnych Collegium Medicum UJ w Krakowie. Badaniem objęto 75 pacjentów z potwierdzonym zakażeniem HIV. Wykazano, obniżenie liczby grzybów w jamie ustnej u pacjentów poddanych leczeniu antyretrowirusowemu oraz zwiększenie wrażliwości grzybów na flukonazol.

    Streszczenie angielskie: Oral cavity is the site of numerous HIV infection manifestations. Oral mucosa candidiasis is the most common one. It may be the earliest sign of the underlying disease. Long lasting observations give evidence that antiretroviral therapy is beneficial also in the cases of this opportunistic infection because it reduces both the number and severity of relapses, however, the prolongation of the patients' survival time creates the need of antifungal therapy prolongation, and thorough observation of its effectiveness and methods. We decided to analyze the influence of antiretroviral therapy with at least three drugs on the development of oral mucosa candidiasis in the out- and inpatietns of the Jagiellonian University Medical College Clinic of Infectious Diseases (or Outpatient Clinic) in Cracow. The study was carried out in 75 patietns with confirmed HIV infection. We have shown a decrease in the number of fungi present in the oral cavity in patients under antiretroviral treatment as well as higher susceptibiltiy to fluconazole.


    1112/2523

    Tytuł oryginału: Smooth-muscle progenitor cells of bone marrow origin contribute to the development of neointimal thickenings in rat aortic allografts and injured rat carotid arteries.
    Autorzy: Religa Piotr, Bojakowski Krzysztof, Maksymowicz Michał, Bojakowska Maria, Sirsjo Allan, Gaciong Zbigniew, Olszewski Waldemar, Hedin Ulf, Thyberg Johan
    Źródło: Transplantation 2002: 74 (9) s.1310-1315, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 304,909

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • transplantologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: This study indicates that circulating progenitors of bone marrow orgin give to cells with smooth muscle-like properties during formation of neointimal thickenings in the arterial wall after allotransplantation and after balloon injury. A segment of abdominal aorta was transplanted from female F344 to male LEW rats, and the grafts were analyzed for male cells by using the SRY gene a marker. Immunostaining demonstrated that CD45-positive leukocytes made up 35-45 p.c. of the neointimal cells during the 8-week period eamined. Concurrently, up to 70 p.c. of the neointimal cells were of host origin, as shown by real-time polymerase chain reaction for the SRY gene (Y chromosome). This suggests that te neointima contained host cells also of noniflammatory character. Accordingly, many cells positive for smooth-muscle ŕ-actin were detected in this layer. To explore the possible bone marrow origin of allograft cells, female LEW rats were irradiated and substituted with bone marrow from male LEW rats. Subsequently, the animals received an aortic transplant from female F344 rats or were exposed to a balloon injury of the carotid artery. Immunostaining and real-time polymerase chain reaction confirmed the above findings, but the fractions of leukocytes and SRY-positive cells were lower in the carotids than in the allografts. Combined primed in situ labelin and immunostaining verified that not only inflammatory but also smooth muscle-like cells of male origin appeared in the vessel wall in both situations. These observations suggest that the smooth-muscle cells that participate in the development of neointimal lesions during vascular disease may, in part, originate from circulating progenitors.


    1113/2523

    Tytuł oryginału: Some aspects of hemostasis in CAPD patients treated with erythropoietin.
    Autorzy: Małyszko Jolanta, Suchowierska Ewa, Małyszko Jacek S., Myśliwiec Michał
    Źródło: Kidney Blood Press. Res. 2002: 25 (4) s.240-244, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,314

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Bleeding diathesis and simultaneous thrombotic complications may be seen in dialyzed patients. Erythropoietin may shift the precarious balance of the hemostatic system towards thrombosis. Thrombin activatable fibrinolysis inhibitor (TAFI) is a key protein linking coagulation and fibrinolysis. Methods: The effects of 3-month erythropoietin treatment on some hemostatic parameters - TAFI, fibrinolytic activity index (FAI), markers of ongoing coagulation (thrombin-antithrombin complexes and prothrombin fragments 1 + 2), marker of ongoing fibrinolysis (plasmin-antiplasmin complexes) and marker of endothelial cell injury (thrombomodulin) - were studied in 17 patients on continuous ambulatory peritoneal dialysis (CAPD). Patients on CAPD not treated with rHuEPO were also studied. Healthy volunteers served as a control group. 2,000 U erythropoietin was given subcutaneously three times a week. Commercially available kits were used to determine hemostatic parameters. Results: All the hemostatic parameters studied were significantly higher in CAPD patients when compared to the control group. All these hemostatic parameters except the plasmin-antiplasmin complexes did not differ significantly between patients before rHuEPO therapy and patients without rHuEPO. Erythropoietin therapy resulted in a significant decrease in plasmin-antiplasmin complexes, a significant rise in FAI after 3 months of drug administration, and a tendency to decrease the TAFI concentration and activity (after 1 month, p = 0.11 and p = 0.10, respectively; after 3 months p = 0.07 and p = 0.06, respectively)...


    1114/2523

    Tytuł oryginału: Lymphocytes in the structure of non-neoplastic goitre.
    Autorzy: Biczysko Maciej, Stajgis Paweł, Żeromski Jan
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.73-81, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • pediatria
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Mononuclear cells infiltrating the thyroid in various pathological states including those of the autoimmune etiology are common. The role of mononuclear onfiltrates in Hashimoto's goiter or Graves-Basedow disease is well understood. The present study was undertaken to analyze the immunophenotype of lymphocytes and the occurrence of antigen presenting cells in Graves-Basedow disease, toxic nodular goiter or simple goiter to compare these disease entitis with respect to their role in autoimmunization with thyroid antigens. Ninety-four thyroid specimens obtained from goiter patients undergoing surgery were studied. Cryostat sections were investigated with a panel of antibodies against antigens of lymphocyte differentiation using immunohistochemistry by APAAP. Semiquantitative technique was used to count the cells with positive reactivity in the visual field magnified 400 times under a light microscope. The structure of goiter varying in etiology contained all basic lymphocyte subpopulations and antigen presenting cells. T lymphocytes, especially CD3+, CD4+ cells were predominant, however the differences did not significantly correlate with any of the above mentioned patient group. There were also the signs of activation of infiltrate cells confirmed by a positive reaction with antibodies against class II MHC antigens. However, the presence of these cells did not correlate significantly with any of the analyzed groups. Furthermore, the expression of HLA class II antigens on epithelial calls of the thyroid was found in all groups, however much frequently in Graves-Basedow disease and toxic nodular goiter. This indicates a possibility of autoimmunization...


    1115/2523

    Tytuł oryginału: Degenerated lumbar intervertebral disc. A morphological study.
    Autorzy: Lebkowski Wojciech J., Dzięcioł Janusz
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.83-86, il., bibliogr. 8 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Acording to many investigators, lumbar disc herniation is formed by the nucleus pulposus displaced to the vertebral canal through the cracks in the annulus fibrosus as a final result of disc degeneration. Specimens obtained during 187 disc surgeries were studied to identify the morphological nature of various of disc herniation, especially protrusion and prolapse. In 29 p.c. of cases the herniated part was annulus fibrosus and in 21.5 p.c. cases the annulus fibrosus was seriously involved. Simultaneously 308 autopsy specimens were studied. On gross examination the signs of degeneration were advanced in 82, and strongly pronounced in 42. In 15 specimens, aged 40 years or older, fibre bundles werer reversed to normal convex orientation producing annulus fibrosus bulge. Microscopic examination showed pronounced myxomatous degeneration within the annulus fibrosus. In these circumstances, we belive that general opinion must be verified. Because in some herniations the nuclei pulposes are not involved and herniations are solety prolapses of annulus fibrosus. So, the lumbar intervertebral disc herniation should be classified on the basis of histological examinations as a herniation of nucleus pulposus, herniation of annulus fibrosus or as a mixed type herniation where both disc elements are involved.


    1116/2523

    Tytuł oryginału: Is it possible to identify siblings by studying bone marrow under a microscope? Two unusual cases of Gaucher disease.
    Autorzy: Papla Bolesław, Machaczka Maciej, Skotnicki Aleksander B.
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.87-90, il., bibliogr. 8 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Two cases of Gaucher disease have been reported in siblings, in whom an unusual similar histological pattern permitted the pathologist (BP) to identify family relation of patients bearing different names.


    1117/2523

    Tytuł oryginału: Nephrogenic adenoma of the urinary bladder - a case report and review of the literature.
    Autorzy: Chosia Maria, Świtała Jerzy, Domagała Wenancjusz
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.91-95, il., bibliogr. 26 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Nephrogenic adenoma is a rare benign of the urinary tract involving mainly the urinary bladder. The clinical manifestations, endoscopic signs and histopathological pattern of NA should be differentiated from a cancer, which may be a source of misinterpretation. Here we report a case of a 70-year--old man previously treated for papillary urothelial carcinoma. Six months later he developed a tumour, giving rise to a suspicion of recurrence. Histopathologically the tumour was diagnosed as nephrogenic adenoma. It is the first case of nephrogenic adenoma in Polish literature.


    1118/2523

    Tytuł oryginału: Rhabdomyosarcomatous (myoblastic ?) phentype of metastatic malignant melanoma. A case report.
    Autorzy: Pasz-Walczak Grażyna, Jesionek-Kupnicka Dorota, Kubiak Robert, Biernat Wojciech, Sygut Jacek, Kordek Radzisław
    Źródło: Pol. J. Pathol. 2002: 53 (2) s.97-100, il., bibliogr. 12 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Melanoma may present a great variety of cell morphology and mimic virtually almost all other neoplasms, and metastatic lesions pose major diagnostic diffimulties. A typical immunoreactive profile of melanoma is: S-100p- and HMB-45-positivity, but these markers are not always present. Other new antigents for melanoma are NKIC3 and Anti-Melan-A (MART-1). This tumor may also present axpression of unspecific markers, as cytokeratin, CEA, EMA, desmin, NFP, GFAP, CD68 and actins. We present here unusual featres of two metastatic melanomas, showing the anaplastic pattern, imunopositive for desmin.


    1119/2523

    Tytuł oryginału: Reliability of endosonography in evaluation of anal fistulae and abscesses.
    Autorzy: Sudoł-Szopińska I[wona], Gęśla J., Jakubowski W[iesław], Noszczyk W[ojciech], Szczepkowski M., Sarti D.
    Źródło: Acta Radiol. 2002: 43 (6) s.599-602, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,623

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective: To assess the reliability of anal endosonography (AES) in the diagnosis of anal fistulae and abscesses. Material and Methods: 86 patients with different types of anal fistulae and abscesses were prospectively examined with a 7.0 MHz transducer. Type of anal fistulae, differentiation between simple and complex tracts, and location of their internal openings were defined. In 66 cases with permeable external opening hydrogen peroxide solution was introduced into the fistula tract. Reliability of AES was defined after surgical treatment of all cases. Results: 74 anal fistulae, including 43 transsphincteric, 11 intersphincteric, 6 suprasphincteric, 3 superficial, and 11 ano-vaginal were found on AES. 27 fistulae were complex, and 47 simple fistulae. In 10 patients a coexisting abscess was found; the remaining 12 abscesses were without any fistula. Surgery confirmed the type of anal fistula in patients (86.5 p.c.), and location of internal openings in 60 cases (81.1 p.c.). All abscesses were confirmed. Conclusion: AES showed high accuracy in diagnosing anal fistulae and abscesses.


    1120/2523

    Tytuł oryginału: Quercetin, apoptosis, heat shock.
    Autorzy: Jakubowicz-Gil Joanna, Rzymowska Jolanta, Gawron Antoni
    Źródło: Biochem. Pharmacol. 2002: 64 (11) s.1591-1595, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 304,395

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro
  • ludzie

    Streszczenie angielskie: The present study was designed to investigate the correlation between the expression level of Hsp27 and Hsp72 and induction of apoptosis in HeLa cells in response to quercetin treatment. Treatment of HeLa cells with quercetin or with 1 hr period of hyperthermia (42ř) increased the number of apoptotic cells. Inhibition of the expression of Hsp72 and Hsp27in tumour cells by anti-sense oligonucleotides, enhanced the induction of apoptosis by quercetin. Heat shock itself had little effect on apoptotic cell death in these cells, but when combinedwith quercetin treatment, caused a significant increase in the number of apoptotic cells. These results suggest that the reduction of Hsps expression in the HeLa cell line promotes the induction of apoptosis by quercetin.


    1121/2523

    Tytuł oryginału: Primary mediastinal large B-cell lymphoma is an important differential among mediastinal tumours.
    Autorzy: Maryniak Renata K., Roszkowska-Purska Katarzyna
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.139-144, il., bibliogr. 29 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The study involved 51 patietns with histopathologically verified diagnoses of primary mediastinal large B-cell lymphoma (PMBL). Clinically they presented as the anterior mediastinal tumours, frequently with the superior vena cava syndrome (21 patietns) and usually (in 42 out of 51) without involvement of other locations. Morphologically the tumours were very pleomorphic. Histopathologically they were composed of germinal center cells, clear cells or polymorphic cells of various size and shape. However, there were also PMBLs composed of cells resembling Reed-Sternberg and Hodgkin cells and small cells. Various types of stromal sclerosis were evident in most biopsies. Due to lymphoma patterns mimicking other tumours with primary or secondary mediastinal location it was necessary to use a panel of immunocytochemical stains. CD20 staining proved to be indispensable for distinguishing PMBL. The patients were treated with CHOP or MEVA (V - VIII courses) followed by radiotherapy of the mediastinum (3600 - 4200cGy/t). Complete remission was obtained in 21 patients with overall survival ranging from 36 to 99 months. A total of 24 patients are alive, 3 of them live with persisting disease. One patient was lost to follow up, 26 died despite the treatment due to persistnece of mediastinal tumour or dissemination to distant organs.


    1122/2523

    Tytuł oryginału: Molecular aspects of bone healing and remodeling.
    Autorzy: Szczęsny Grzegorz
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.145-153, tab., bibliogr. 136 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The process of fracture healing involves a complex series of coordinated cellular and molecular processes leading to removal of material contaminating the wound, angiogenesis validating restoration of disrupted microcirculation, and restoration of bone continuity by activation, proliferation and chemotaxis of bone progenitors from surrounding periosteum and endosterum. The regulation of various cell populations that orchestrate in this rocess depends on the biological effect evoked by cytokines and growth factors. The paper presents the state-of-the-art knowledge of the influence of growth factors and cytokines, namely TGF-á, BMP, IGF, PDGF, FGF, NO, IL-1, IL-6, IL-11 on the process of fracture healing.


    1123/2523

    Tytuł oryginału: A correlation between immunoexpression of CD44, ŕ-SMA and CD68+ cells in IgA-nephropathy and in mesangial proliferative IgA-negative glomerulonephritis.
    Autorzy: Wągrowska-Danilewicz Małgorzata, Danilewicz Marian
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.155-162, il., tab., bibligor. 37 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Immunoperoxidase staining was carried out using monoclonal antibodies against CD44, ŕ-smooth muscle actin and CD68 on renal biopsy specimens from patients with IgA nephropathy (IgAN, n=16) and mesangial proliferative IgA-negative glomerulonephritis (MesProGN, n=15). As a control 10 biopsy specimens of the kidneys removed because of trauma were used. The results showed increase in glomerular CD44+ cells and CD68+ cells in IgAN biopsies as compared with controls and MesProGN. The intensity of glomerular ŕ-SMA was increased in IgAN and MesProGN as compared with controls, but no statistical differences were shown in glomerular expression of ŕ-SMA between IgAN and MesProGN. In both study groups there were significant positive correlations between glomerular CD44+ cells and CD68+ cells, as well as the intensity of ŕ-SMA immunostaining. The interstitial expression of CD44 and ŕ-SMA in IgAN patietns was significantly higher as compared with controls and MesProGN group, whereas the mean values of interstitial CD68+ cells did not differsignificantly in these glomerulopatheis. in both IgAN and MesProGN there were significant positive correlations between interstitial expression of CD44 and ŕ-SMA, between intensity of CD44 immunostaining and 68+ cells as well as interstitial volume. In conclusion, our study suggests possible role of CD44 interaction in macrophage recruitment and the development of interstitial fibrosis and glomerular sclerosis in both glomerulopathies.


    1124/2523

    Tytuł oryginału: Rudolf Virchow and presentation of his scientific achievement in Polish medical magazines in the 19th century and the beginning of 20th century.
    Autorzy: Sabat Daniel, Dziembała Anna, Panasiewicz Małgorzata
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.163-168, il., bibliogr. 26 poz.
    Sygnatura GBL: 301,852

    Typ dokumentu:
  • praca historyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XIX wieku

    Temat osobowy:
  • Virchow
  • Rudolf 1821-1902

    Streszczenie angielskie: The development of pathological anatomy in the second half of the 19th century was mainly associated with the scientific activity of Rudolf Virchow. last year we celebrated the 180th birth anniversary and this year the 100th death anniversary of this outstanding man. The paper presents the scientific achievements of Rudolf Virchow as it was presented in Polish medical magazines in the 19th century and the beginning of 20th century. In 1858, his theory of cellular pathology became a basis for the understanding and fight against pathologic processes in living organisms. The theory also contributed to an increased interest in pathologic anatomy, especially histopathology and Virchow himself. in 1859 an extensive summary of the article, issued a year before, entitled "Cellular pathology based on physiolgoical and pathological tehroy of tissues" appeared in the subsequent issues of "Tygodnik Lekarski' ("Medical Weekly"). Also a translation of the XI chapter of "Cellular pathology..." devoted to nerve tissue appeared in the same magazine. this is the only treatise in Polish onteh most important work in the history of pathological anatomy of the 19th century. Three years later, in 1862, Włodzimierz Brodowski delivered to the students of Medical and Surgery Academy in Warsaw a lecture "Introduction to the lecture on pathological anatomy" which was later printed in "Pamiętnik Towarzystwa Lekarskiego Warszawskiego" ("diary of Warsaw Medical Association"). He presented the development of pathological anatomy along iwht the achievements of Virchow...


    1125/2523

    Tytuł oryginału: Silicoproteinosis of the lung in a 49-year-old man.
    Autorzy: Papla Bolesław, Dubiel-Bigaj Magdalena, Malinowski Eugeniusz
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.169-171, il., bibliogr. 6 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: We report a rare case of silicosis, histologically corresponding to silicoproteinosis and tuberculosis, in a man working consecutively as a miner, blacksmith and founder. A microscopic study revealed deposits in alveoli, in which immunohistochemistry did not reveal surfactant (SP-A), that was present in the alveolar fluid in alveolar lipoproteinosis.


    1126/2523

    Tytuł oryginału: Ectopic thyroid tissue as a tumour of the heart - case report and review of the literature.
    Autorzy: Chosia Maria, Waligórski Szymon, Listewnik Maria H., Wiechowski Seweryn
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.173-175, il., bibliogr. 14 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • onkologia
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Here we report a case of a 48-year-old woman with ectopic thyroid tissue in the right ventricle. The tumour involved 1/3 of the ventricle and adhered to the myocardium. The lesion was removed completely and a bioprosthesis was placed due to tricuspid insufficiency, and then a pacemaker was implanted. The diagnosis was made upon examination of the postoperative tissue. The paper discusses embryological implications of the development of thyroid tissue in the heart. This case is first in the polish literature.


    1127/2523

    Tytuł oryginału: Primary undifferentiated small cell carcinoma (Merkel cell carcinoma) in a patient after heart transplantation - case report.
    Autorzy: Maksymiuk Beata, Wygoda Andrzej, Zakliczyński Michał, Paleń Piotr
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.177-180, il., bibliogr. 17 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • onkologia
  • transplantologia
  • traumatologia i ortopedia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Here we report a case of a 48-year-old man after heart transplantation in whom two years after the procedure an appendage germ tumour was diagnosed and a year after its removal in the same area a primary undifferentiated small cell carcinoma (Merkel cell carcinoma) with metastases to the axillary lymph nodes was detected. The diagnosis of Merkel cell carcinoma was confirmed by immunohistochemical staining showing a typical perinuclea expression of cytokeratin 20 with the absence of reactivity with wide spectrum cytokeratin and the presence of neuroendocrine markers of neurone-specific enolase and chromogranin. Primary undifferentiated small cell carcinoma occurs more frequently in patients receiving immunosuppressive treatment as compared with a general population and occurs much more frequently in those below 50 years of age.


    1128/2523

    Tytuł oryginału: Mice and humans: chromosome engineering and its application to functional genomics.
    Autorzy: Klysik Jan
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.553-569, il., bibliogr. [93] poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Functional modelling of human genes and diseases requires suitable mammalian model organisms. For its genetic malleability, the mouse is likely to continue to play a major role in defining basic genetic traits and complex pathological disorders. Recently, gene targeting tecyniques have been extended towards developing new engineering strategies for generating extensive lsions and rearrangements in mouse chromosomes. While these advances create new opportunities to address similar aberrations observed in human diseases, they also open new ways of scaling-up mutagensis projects that try to catalogue and annotate cellular functions of mammalian genes.


    1129/2523

    Tytuł oryginału: Molecular basis of inherited predispositions for tumors.
    Autorzy: Lubiński Jan, Górski Bohdan, Kurzawski Grzegorz, Jakubowska Anna, Cybulski Cezary, Suchy Janina, Dębniak Tadeusz, Grabowska Ewa, Lener Marcin, Nej Katarzyna
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.571-581, il., tab., bibliogr. [63] poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: On the basis of literature data and own experience the authors review the current knowledge about the molecular basis of inherited predispositions for tumors. They hpothesize that in the near perspective 5-10 years studies using existing registry data/metarial and the latest novel tehcnology will allow the identification of the molecular background for the majority of hereditay cancers which will have normous practical consequences especially for the prevention of malignancies.


    1130/2523

    Tytuł oryginału: Recognition and repair of DNA-cisplatin adducts.
    Autorzy: Woźniak Katarzyna, Błasiak Janusz
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.583-596, il., tab., bibliogr. [100] poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Anticancer activity of cisplatin (cis-diamminedichloroplatinum) is believed to result from its interaction with DNA. The drug reacts with nucleophilic sites in DNA forming monoadducts as well as intr-and interstrand crosslinks. DNA-cisplatin adducts are specifically recognized by several proteins. They can be divided into two classes. One constitutes proteins which recognize DNA damage as an initial step of the nucleotide excision and mismatch repari pathways. The other class contains proteins stabilizing cellular DNA-protein and protein-protein complexes, including non-histone proteins stabilizing cellular DNA-protein and protein-protein complexes, including non-histone proteins from the HMG (high-mibility-group) family. They specifically recognize 1,2-interstrand d(GpG0 and d(ApG) crosslinks of DNA-cisplatin adducts and inhibit their repair. Many HMG-domain proteins can function as transcription factors, e.g. UBF, an RNA polymerase I transcription factor, the mamalian testis-determining factor SRY and the human mitochondrial transcription factor mtTFA. Moreover, it seems that some proteins, which probably recognize DNA-cisplatin adducts non-specifically, e.g. actin and other nuclear matrix proteins, can disturb the the structural and functional organization of the nucleus and whole cell. The formation of complexes between DNA and proteins in the presence of cisplatin and the changes in the cell architecture may account for the drug cytotoxicity.


    1131/2523

    Tytuł oryginału: NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
    Autorzy: Borowski Peter, Niebuhr Andreas, Schmitz Herbert, Hosmane Ramachandra S., Bretner Maria, Siwecka Maria A., Kulikowski Tadeusz
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.597-614, il., tab., bibliogr. [82] poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are invovled in transcription and replication of viral single-stranded RNA genomes. The enzymatic acitivities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme and attractive target for development of FLaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, eupdate the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase anddescribe the different mechanisms by which the compouneds act. Some of the compounds reviewed herein could show potential utility as antiviral agents atgainst Flaviviridae viruses.


    1132/2523

    Tytuł oryginału: Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro.
    Autorzy: Kowalczyk Piotr, Woszczyński Marek, Ostrowski Jerzy
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.615-624, il., bibliogr. s. 622-624
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The ribosomal protein S2 (RPS2) is encoded by a gene from the highly conserved mammalian repetitive gene family LLRep3. It participates in aminoacyl-transfer RNA binding to ribosome, potentially affecting the fidelity of mRNA translation. These studies were designed to measure the expressiono f RPS2 during increased cell proliferation. Using Western and Northern blot analyses, we found that the levels of RPS2 protein and its corresponding mRNA were higher in mouse hepatocellular carcinoma, in mouse livers after one-third partial hepatectomy, and in serum-starved cultured hepatocytes following serum treatment. Our study shows that the increased expression of RPS2 correlated with increased cell proliferation. However, whether the altered expression of this protein reflects its involvement in cellular proliferationor represents an associated phenomena is still a key question that needs to be explored.


    1133/2523

    Tytuł oryginału: Optimisation of transfection conditions of CD34+ hematopoietic cells derived from human umbilical cord blood.
    Autorzy: Ołdak Tomasz, Kruszewski Marcin, Machaj Eugeniusz Krzysztof, Gajkowska Agnieszka, Pojda Zygmunt
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.625-632, il., tab., bibliogr. s. 630-632
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Human umbilical cord blood is frequently used as a source of transplantable hematopoietic cells and more recently as a target of gene therapy - a new approach for treatment of various disorders. The aim of our study was optimisation of the transfection conditions of cord blood-derived CD34+ hematopoietic cells. Mononuclear cells fraction was isolated from cord blood samples by density gradient centrifugation. Subsequently, CD34+ hematopoietic cells were separated on immunomagnetic MiniMACS columns. Pure population of CD34+ cells was incubated in a serum free medium supplemented with thrombopoietin, stem cell factor and Flt-3 ligand for 48 h and then transfected with plasmid DNA carrying the enhanced version of green fluorescent protein (EGFP) as a reporter gene. We studied the influence of various pulse settings and DNA concentrations on teh transfection efficiency, measured by flow cytometry as the fluorescence of target cells due to the expression of EGFP. The optimal settings were as follows: 4 mm cuvette, 1600 ćF, 550 V/cm, and 10 ćg of DNA per 500 ć1. With these settings we obtained a high transfection frequency (41.2 p.c.) without a marked decrease of cell viability. An increase of the pulse capacitance and/or of DNA concentration resulted in a greater electroporation efficiency, but also in a decrease of cell viability. In conclusion, the results described here allow one to recommend electroporation as an efficient method of gene delivery into CD34+ hematopoietic cells derived from human umbilical cord blood.


    1134/2523

    Tytuł oryginału: Spectral properties of phthalocyanines incorporated into resting and stimulated human peripheral blood cells.
    Autorzy: Waszkowiak Aneta, Frąckowiak Danuta, Wiktorowicz Krzysztof, Miyake Jun
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.633-641, il., bibliogr. s. 640-641
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Human peripheral blood cells stimulated by phytohemagglutinin (which serve as a model of cancerous cells) and resting cells were incubated in dimethyl sulfoxide solutions of various phthalocyanines. In order to diminish the influence of atmospheric oxygen the cells were embedded in a polymer (polyvinyl alcohol) film. Fluorescence spectra of the samples were measured over two regions of excitation wavelengths: at 405 nm (predominant absorption of the cell material) and in the regions of strong absorption of phthalocyanines (at about 605 nm and 337 nm). The intrinsic emission of cell material became changed as a result both of cells' stimulation and of incubation of cells in dye solution. In most cases the stimulated cells when stained by dye exhibited higher long wavelength fluorescence intensity than resting cells. this suggests higher efficiency of dye incorporation into cancerous cells than into healthy cells. the absorption spectra of samples were also measured. The spectra of various phthalocyanines in incubation solvent, in polymer and in the cells embedded in polymer, were compared. The comparison of properties of the cells stimulated for different time periods enabled to establishe the conditions of stimulation creating a population of cells incorporating a large number of sensitizing molecules.


    1135/2523

    Tytuł oryginału: Adhesion properties of human bladder cell lines with extracellular matrix components: the role of integrins and glycosylation.
    Autorzy: Lityńska Anna, Przybyło Małgorzata, Pocheć Ewa, Laidler Piotr
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.643-650, il., bibliogr. s. 649-650
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Integrin subunits present on human bladder cells displayed heterogeneous functional specificity in adhesion to extracellular matrix proteins (ECM). The non-malignant cell line (HCV29) showed significantly higher adhesion efficiency to collagen IV, laminin (LN) and fibronectin (FN) than cancer (T24, Hu456) and v-raf transfected (BC3726) cell lines. Specific antibodies to the ŕ2, ŕ5 and á1 integrin subunits inhibited adhesion of the non-malignant cells, indicating these integrin participation in the adhesion to ECM proteins. in contrast, adhesion of cancer cells was not inhibited by specific antibodies to the á1 integrin subunit. Antiboedies to ŕ3 integrin increased adhesion of cancer cells to collagen, LN and FN, but also of the HCV29 line with colagen. It seems that ŕ3 subunit plays a major role in modulation of other integrin receptors especially in cancer cells. Differences in adhesion to ECM proteins between the non-malignant and cancer cell lines in response to Gal and Fuc were not evident, except for the v-raf transfected cell line which showed a distinct about 6-fold increased adhesion to LN on addition of both saccharides. N-Acetylneuraminic acid inhibited adhesion of all cell lines to LN and FN irrespective of their malignancy.


    1136/2523

    Tytuł oryginału: The effect of Arg209 to Lys mutation in mouse thymidylate synthase.
    Autorzy: Cieśla Joanna, Gołos Barbara, Wałajtys-Rode Elżbieta, Jagielska Elżbieta, Płucienniczak Andrzej, Rode Wojciech
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.651-658, il., tab., bibliogr. s. 657-658
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • hematologia
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Mouse thymidylate synthase R209K (a mutation corresponding to R218K in Lactobacillus casei), overexpressed in thymidylate synthase-deficient Escherichia coli strain, was poorly soluble and with only feeble enzyme activity. The mutated protein, incubated with FdUMP and N5,10 -methylenetetrahydrofolate, did not form a complex stable under conditions of SDS/polyacrylamide gel electrophoresis. The reaction catalyzed by the R209K enzyme (studied in a crude extract), compared to that catalyzed by purified wild-type recombinant mouse thymidylate synthase, showed the Km value for dUMP 571-fold higher and Vmax value over 50-fold (assuming that the mutated enzyme constituted 20 p.c. of total crude extract protein) lower. Thus the ratios kcat, R209K/kcat, 'wild' and (kcat, R209K/Km, R209K**dUMP)/(kcat, 'wild'/Km, 'wild'**dUMP) were 0.019 and 0.000032, respectively, documenting that mouse thymidylate synthase R209, similar to the corresponding L. casei R218, is essential for both dUMP binding and enzyme reaction.


    1137/2523

    Tytuł oryginału: Effect of An tracts within the UP element proximal subsite of a model promoter on kinetics of open complex formation by Escherichia coli RNA polymerase.
    Autorzy: Kolasa Iwona K., Łoziński Tomasz, Wierzchowski Kazimierz L.
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.659-669, il., tab., bibliogr. s. 667-669
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: In the open transcription complex (RPo), Escherichia coli RNA polymerase sigma70 and ŕ subunits are known to be in contact with each other and with the promoter region overlapping the -35 hexamer and the proximal part of the UP element. To probe the effect of AnDNA bending tracts in this region on initiation of transcription, kinetics of the formation of RPo by Escherichia coli RNA polymerase at two groups of synthetic consensus-like promoters bearing single DNA bending tracts (i) A5 within the proximal subsite region of the UP element (promoters Pk and Pl) and (ii) A5 (Pg) or A8 (Pm) in the region including the downstream end of the proximal UP subsite and the -35 consensus hexamer was studied in vitro using the fluorescence-detected abortive initiation assay. The kinetic data obtained demonstrate that the overall second-order rate constant Ka of RPo formation is: (i) by almost one order of magnitude larger at Pk and Pl, relative to that at a control unbent promoter, and mainly due to a higher value of the equilibrium constant, k1, of the initial closed complex; and (ii) several-fold smaller at Pg and Pm owing to a strongly decreased value fo k1. For Pm, the latter parameter was found to be dependent exponentially on four Mgý+ ions, as compared with the seven ions remaining in equilibrium with the initial closed complex at the parent Papromoter. This indicates that promoter region bearing a stiff A8úT8 fragment of B'-DNA forms a smaller number of ionic contacts with the ŕ subunit. These findings provide a new insight to and supprot the present model of interactions between RNA polymerase ŕ and sigma70 subunits with the proximal UP subsite and the -35 region of promoters.


    1138/2523

    Tytuł oryginału: Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues.
    Autorzy: Stachelska Alicja, Wieczorek Zbigniew, Ruszczyńska Katarzyna, Stolarski Ryszard, Pietrzak Monika, Lamphear Barry J., Rhoads Robert E., Darżynkiewicz Edward, Jankowska-Anyszka Marzena
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.671-682, il., tab., bibliogr. s. 679-682
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Translation initiation factor eIF4E binds the m**7G cap of eukaryotic mRNAs and mediates recruitment of mRNA to the ribosome during cap-dependent translation initiation. This event is the rate-limiting step of translation and a major target for translational control. In the nematode Caenorhabditis elegans, about 70 p.c. of genes express mRNAs with an unusual cap structure containing m3ý,ý,**7 G, which is poorly recognized by mammalian eIF4E. C. elegans expresses five isoforms of eIF4E (IFE-1, IFE-2, etc.). Three of these (IFE-3, IFE-4 and IFE-5) were investigated by means of spectroscopy and structural modelling based on mouse eIF4E bound to m**7 GDP. Intrinsic fluorescence quenching of Trp residues in the IFEs by iodide ions indicated structural differences between the apo and m**7 G cap bound proteins. Fluorescence quenching by selected cap analogues showed that only IFE-5 forms specific complexes with both m**7 G- and m3ý,ý,**7 G-containing caps (Kas 2x10**6 M**-1 to 7x10**6 M**-1) whereas IFE-3 and IFE-4 discriminated strongly in favor of M**7 G-containing caps. These spectroscopic results quantitatively confirm earlier qualitative data derived from affinity chromatography. The dependence of Kas on pH indicated optimal cap binding of IFE-3, IFE-4 and IFE-5 at pH 7.2, lower by 0.4 ph units than that of eIF4E from human erythrocytes. these results provide insight into the molecular mechanism of recognition of structurally different caps by the highly homologous IFEs.


    1139/2523

    Tytuł oryginału: Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal.
    Autorzy: Sharma Rajendra, Sharma Abha, Yang Yusong, Awasthi Sanjay, Singhal Sharad S., Zimniak Piotr, Awasthi Yogesh C.
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.693-701, il., bibliogr. s. 700-701
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Earlier studies from our laboratories have shown that RLIP76, a previously described Ral-binding GTpase activating protein (Jullien-Flores et al., 1995, J. Biol. Chem. 270: 22473), is identical with the xenobiotic transporter DNP-SG ATPase, adn can catalyze ATP-dependent transport of glutathione-conjugates as well as doxorubin (Awasthi et al., 2000, Biochemistry, 39: 9327). We have now reconstituted purified bacterially expressed RLIP76 in proteoliposomes, and have studied ATP-dependent uptake of the glutathione conjugate of 4-hydroxynonenal (GS-HNE) by these vesicles. Results of these studies show that RLIP76 reconstituted in proteoliposomes catalyzes ATP-dependent transport of GS-HNE against a concentration gradient. The transport of GS-HNE is saturable with respect to ATP as well as GS-HNE with Km values of 1.4 mM and 2.5 ćM, respectively. These studies demonstrate that RLIP76 mediates active transport of GS-HNE, adn are consistent with our previous work showing that RLIP76-mediated efflux of GS-HNE regulates the intracellular concentration of 4-HNE and thereby affects 4-HNE mediated signaling.


    1140/2523

    Tytuł oryginału: The effects of the interaction of myosin essential light chain isoforms with actin in skeletal muscles.
    Autorzy: Nieznańska Hanna, Nieznański Krzysztof, Stępkowski Dariusz
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.709-719, il., tab., bibliogr. 717-719
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: In order to compare the ability of different isoforms of myosin essential light chain to interact with actin, the effect of the latter protein on the proteolytic susceptibility of myosin light chains (MLC-1S and MLC-1V - slow specific and same as ventricular isoform) from slow skeletal muscle was examined. Actin protects both slow muscle essential light chain isoforms from papain digestion, similarly as observed for fast skeletal muscle myosin (Nieznańska et al., 1998, Biochim. Biophys. Acta 1383: 71). The effect of actin decreases as ionic strength rises above physiological values for both fast and slow skeletal myosin, confirming the ionic character of the actin - essential light chain interaction. To better understand the role of this interaction, we examined the effect of synthetic peptide spanning the 10-amino-acid n-terminal sequences of myosin light chain 1 from fast skeletal muscle (MLC-1F0 (MLCFpep: KKDVKKPAAA), MLC-1S (MLCSpep: KKDVPVKKPA) and MLC-1V (MLCVpep: KPEPKKDDAK) on the myorfibrillar ATPase of fast and slow skeletal muscle. In the presence of MLCFpep, we observed an about 19 p.c. increase, and in the presence of MLCSpepabout 36 p.c. increase, in the myofibrillar ATPase activity of fast muscle. On the other hand, in myofibrillar preparations from slow skeletal muscle, MLCSpep as well as MLCVpep caused a lowering of the ATPase activity by about 36 p.c. The above results suggest that MLCSpep induces opposite effects on ATPase activity, depending on the type of myofibrils, but not through its specific N-terminal sequence - which differs from other MLC N-terminal peptides...


    1141/2523

    Tytuł oryginału: Comparison of serological specificity of anti-endotoxin sera directed against whole bacterial cells and core oligosaccharide of Escherichia coli J5-tetanus toxoid conjugate.
    Autorzy: Łukasiewicz Jolanta, Jachymek Wojciech, Niedziela Tomasz, Malik-Gębicka Małgorzata, Dzieciątkowska Monika, Lugowski Czesław
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.721-734, il., bibliogr. s. 732-734
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The rough mutants of Gram-negative bacteria are widely used to induce protective antisera but the nature of the target epitope for such antibodies is not precisely defined. Endotoxin is one of several antigens present on the surface of bacterial cells, which are able to elicit specific antibodies. We studied the specificity of antibodies produced against a conjugate of E. coli J5 endotoxin core oligosaccharide with tetanus toxoid. The use of chemically defined antigen for immunisation excludes the possibility of production of antibodies against otehr cell surface antigens. A comparison of this monospecific anti-endotoxin serum whith antiserum against E. coli J5 whole cells was performed in order to distinguish the role that endotoxin core oligosaccharide plays in the itneraction with humoral host defences form that of other potentially important Gram-negative bacterial surface antigens. The reactivity of both sera with smooth and rough lipopolysaccharides was determined in ELISA, immunoblotting and by flow cytometry. BOth antisera reacted with similar specificity with most lipopolysaccharides of identical or related core type. Less distnct reactions with endotoxins of antibacterial serum in comparison with the anti-conjugate serum were found in all serological tests. LPS of E. coli O100 that showed the strongest reactions with both sera was used to stimulate IL-6, TNFŕ and nitric oxide production by the J-774A.1 cell line. BOth sera were used to inhibit that stimulation and no inhibitroy effects of the examined sera in comparison with non-immune serum were observed.


    1142/2523

    Tytuł oryginału: Steroid signal transduction activated at the cell membrane: from plants to animals.
    Autorzy: Marcinkowska Ewa, Więdłocha Antoni
    Źródło: Acta Bioch. Pol. 2002: 49 (3) s.735-745, il., tab., bibliogr. s. 742-745
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Steroid hormones in plants and in animals are very important for physiological and developmental regulation. In animals steroid hormones are recognized by nuclear receptors, which transcriptionally regulate specific target genes following binding of the ligand. In addition, numerous rapid effects generated by steroids appear to be mediated by a mechanism not depending on the activation of nuclear receptors. Although the existence of separate membrane receptors was postulated many years ago and hundreds of reports supporting this hypothesis have been published, no animal membrane steroid recepotr has been cloned to date. Meanwhile, a plant steroid receptor from Arabidopsis thaliana has been identified and cloned. It is a transmembrane protein which specifically recognizes plant steroids (brassinosteroids) at the cell surface and has a serine/threonine protein kinase activity. It seems that plants ahve no intracellular steroid receptors, since there are nog enes homologus to the family of animal nuclear steroid receptors in the genome of A. thaliana. Since the reason of the rapid responses to steroid hormones in animal cells still remains obscure we show in this article two possible explanations of this phenomenon. Using 1,25-dihydroxyvitamin D3 as an example of animal steroid hormone, we review results of our and of otehr groups concerdatn with the hypothesis of membrane steroid receptors. We also review the results of experiemnts performed with ovarian hormones, that led their authors to the hypothesis explaining rapid steroid actions without distinct membrane steroid receptors...


    1143/2523

    Tytuł oryginału: Proteus syndrome: a case with clonal chromosome aberration.
    Autorzy: Gieruszczak-Białek D[orota], Illiszko M[ariola], Mikołajczyk W[iesław], Skórka A[gata], Korniszewski L[ech]
    Źródło: Genet. Couns. 2002: 13 (4) s.427-432, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,584

    Hasła klasyfikacyjne GBL:
  • onkologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska

    Streszczenie angielskie: Proteus syndrome is a disorder characterized by overgrowth of multiple tissues, connective tissue nevi, epidermal nevi and hyperostoses with asymmetric involvement. The clinical expression of the disorder is extremal variable. Molecular pathogenesis of the syndrome is unknown but it is hypothesized that it resulted from a somatic alternation of a gene leading to mosaic effects that would be lethal if the mutation was carried in nonmosaic fashion, and this may explain the variability among patients. We report a new case who presented at birth with asymmetric hypertrophy of the bones and soft tissues of fingers and a tumor of the chest. Cytogenetic analysis of the excised tumor revealed clonal chromosome aberration: mos46, XY, add(9) (p13) [5]/46,XY[30]. During follow up tumors of the rectum and urinary bladder were diagnosed.


    1144/2523

    Tytuł oryginału: Modulation of melanocortin-induced changes in spinal nociception by ć-opioid receptor agonist and antagonist in neuropathic rats.
    Autorzy: Starowicz Katarzyna, Przewłocki Ryszard, Gispen Willem Hendrik, Przewłocka Barbara
    Źródło: Neuroreport 2002: 13 (18) s.2447-2452, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,357

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Co-localization of opioid and melanocortin receptor expression, especially at the spinal cord level in the dorsal horn and in the gray matter surrounding the central canal led to the suggestion that melanocortins might play a role in nociceptive processes. In the present studies, we aimed to determine the effects of melanocortins, administered intrathecally, on allodynia, and to ascertain whether there is an interaction between opioid and melanocortin systems at the spinal cord level. Neuropathic pain was induced by chronic constriction injury (CCI) of the right sciatic nerve in rats. Tactile allodynia was assessed using von Frey filaments, while thermal hyperlagesia wa evaluated in cold water allodynia test. In the present experiments, melanocortin receptor antagonist, SHU9119 was much more potent than ć-opioid receptor agonist, morphine after their intrathecal (i.th.) administration in neuropathic rats. SHU9119 alleviated allodynia in a comparable manner to DAMGO, a selective and potent ć-opioid receptor agonist. Administration of melanocortin receptor agonist, melanotan-II (MTII) increased the sensitivity to tactile and cold stimulation. Moreover, we demonstrated that the selective blockade of ć-opioid receptor by cyprodime (CP) enhanced antiallodynic effect of SHU9119 as well as pronociceptive action of MTII, whereas the combined administration of ć receptor agonist (DAMGO) and SHU9119 significantly reduced the analgesic effect of those ligands. DAMGO also reversed the proallodynic effect of melanocortin receptor agonist...


    1145/2523

    Tytuł oryginału: Luminance and chromatic contrast sensitivity in dyslexia: the magnocellular deficit hypothesis revisited.
    Autorzy: Bednarek Dorota B., Grabowska Anna
    Źródło: Neuroreport 2002: 13 (18) s.2521-2525, il., bibliogr. 29 poz.
    Sygnatura GBL: 313,357

    Hasła klasyfikacyjne GBL:
  • pediatria
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The hypothesis of a magnocellular channel deficit in dyslexia was tested. Subjects were 10-year-old dyslexics and normal readers. Psychophysical thresholds for luminance and chromatic contrasts were estimated using black and white and red and green sinusoidal gratings of various spatial frequencies, presented in static and dynamic conditions (drift and reversal). Significant group differences were found for luminance contrast, with a higher sensitivity in dyslexics. No group differences were obtained for chromatic contrast. High luminance sensitivity correlated with low reading and writing skills. The typical finding of an increase contrast sensitivity to low spatial frequency gratings, due to their dynamic presentations, was absent in dyslexics. The results provide support for the magnocellular deficit hypothesis. The pattern of this deficit, however, is much more complex than that emerging from previous research.


    1146/2523

    Tytuł oryginału: Exercise increases mRNA levels for adhesion molecules N-CAM and LI correlating with BDNF response.
    Autorzy: Macias Matylda, Fehr Susanne, Dwornik Anna, Sulejczak Dorota, Wiater Maciej, Czarkowska-Bauch Julita, Skup Małgorzata, Schachner Melitta
    Źródło: Neuroreport 2002: 13 (18) s.2527-2530, il., bibliogr. 27 poz.
    Sygnatura GBL: 313,357

    Hasła klasyfikacyjne GBL:
  • genetyka
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: In situ hybridization was used to evaluate whether long-term moderate locomotor exercise, which up-regulates BDNF and TrkB levels in the spinal gray matter of the adult rat, similarly influences the expression of the cell adhesion molecules N-CAM and LI. Exercise doubled the level of N-CAM mRNA hybridization signal in the lumbar spinal gray. The increase in LI mRNA was less consistent. N-CAM mRNA levels slightly increased in the white matter. BDNF mRNA levels also increased in cells of the ventral horn and the white matter due to the exercise. Theses results suggest that exercise-induced rearrangements of the spinal network involve N-CAM, LI and BDNF, crucial in different aspectcs of synaptic plasticity and synapse formation.


    1147/2523

    Tytuł oryginału: Un cas de r‚cup‚ration partielle de I'audition apr‚s I'ablation d'un neurinome de I'angle pontoc‚r‚belleux.
    Tytuł angielski: Partial hearing recovery after cerebello-pontine angle neurinoma removal.
    Autorzy: Bochenek W., Hatliński G., Kukwa A[ndrzej], Krajewski R.
    Źródło: Rev. Laryngol. Otol. Rhinol. 2002: 123 (3) s.199-201, il., bibliogr. 5 poz., sum.
    Sygnatura GBL: 300,240

    Hasła klasyfikacyjne GBL:
  • neurologia
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: A cause of a 44 year-old women farmer with a total deafness and lack of vestibular function on the left side operated upon the cerebello-pontine cystic neuroma 2.5 x 1.5 cm large via the retromastoidal craniectomy is presented. Despite of the negative audiological tests' results the cochlear nerve flatten on the tumor was cautiously separated. Some time after surgery, she observed "a partial recovery of hearing" in the operated ear confirmed by the tonal (mean 0.5-2 kHz 36 dBHL) vocal SRT 70 dB), BERA and EOAEs tests. The paralysis of the left vestibular function did not recover. In consecutive audiogram a notch at 6 kHz 15 dB deep appeared in the operated ear and one can presume an increased vulnerability of this ear to the noise of the agricultural machines used by then by the patient.


    1148/2523

    Tytuł oryginału: Influence du lanr‚otide sur la concentration s‚reique de prolactine chez les patients atteints de tumeurs somato-lactotropes.
    Tytuł angielski: Effect of lanreotide on prolactin level in patients with pituitary mixed tumors.
    Autorzy: Wasko R., Sawicka J., Stachowiak C., Kozak W., Junik R., Sowiński J.
    Źródło: Ann. Endocrinol. 2002: 63 (6 cz. 1) s.532-535, il., bibliogr. 12 poz., sum.
    Sygnatura GBL: 301,225

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Acromegaly is a disease caused by a pituitary tumor (somatotropinoma) or by ectopic secretion of GH or IGF-1. About 15 p.c. of tumors secrete not only GH but PRL as well. Last time a lanreotide and an octreotide (the somatostatine analogues) are useful in the therapy of acromegaly. We observed the influence of the lanreotide on GH and prolactin. We noticed that the lanreotide caused not only serum level reduction of a growth hormone but also prolactine in patients with mixed pituitary tumors.


    1149/2523

    Tytuł oryginału: The role of solar ultraviolet irradiation in zoster.
    Autorzy: Żak-Prelich M., Borkowski J. L., Alexander F., Norval M.
    Źródło: Epidemiol. Infect. 2002: 129 (3) s.593-597, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,292

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Ultraviolet radiation (UVR) suppresses many aspects of cell-mediated immunity but it is uncertain whether solar UV exposure alters resistance to human infectious diseases. Varicella-zoster virus (VZV) causes varicella (chickenpox and zoster in a defined Polish population over 2 years was recorded and ground level solar UV was measured daily. There was a significant seaonality of UVR. Evidence of seasonal variation was found for all zoster cases and for zoster in males, with the lowest number of cases in the winter. The number of zoster cases with lesions occurring on exposed body sites (the face) demonstrated highly significant seasonality with a peak in July/August. Seasonal models for UVR and zoster cases was found in Marh and the minimum in August/ September, probably explained by the respiratory spread of VZV. It is tempting to speculate that the increase in solar UVR in the summer could induce suppression of cellular immunity, thus contributing to the corresponding rise in the incidence of zoster.


    1150/2523

    Tytuł oryginału: Lichtenstein repair for incarcerated groin hernias.
    Autorzy: Wysocki Andrzej, Poźniczek Marek, Krzywoń Jerzy, Strzałka Marcin
    Źródło: Eur. J. Surg. 2002: 168 (8/9) s.452-454, bibliogr. 25 poz.
    Sygnatura GBL: 300,370

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Objective: To evaluate the use of Lichtenstein tension-free repair for incarcerated groin hernias. Design: Prospective consecutive series. Setting: Tertiary academic surgery department, Poland. Subjects: 27 patients whose incarcerated groin hernias were operated on between November 1997 and June 2001. Intervention: Tension-free hernia repair by the Lichtenstein technique. Main outcome measures: Morbidity, recurrence rates and mortality. Results: There were 2 postoperative deaths unrelated to implantation of the mesh (myocardial and cerebral infarction). In 1 patients a subcutaneous fluid collection was noted and was auccessfully treated by evacuation of the fluid. The remaining 24 patients had no complications during follow-up (mean 18 months, range 2-42 months). Conclusion: Monofilament polypropylene mesh can be successfully used not only in elective operations, but also in emergency operations for incarcerated inguinal hernias.


    1151/2523

    Tytuł oryginału: What are GPs in need of for approaching alcohol-related problems?
    Autorzy: Rodriguez-Martos Dauer Alicia
    Źródło: Probl. Med. Rodz. 2002: 4 (1) s.6-11, tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,528

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: To face alcohol-related problems at a Primary Care setting isn't easy because of many barriers. Among them, an insufficient training negatively influences the perceived self-efficacy and the therapeutic commitment. This article recalls the WHO recommendations for its adoption by faculties for general practitioners and suggests the key components (knowledge, skills and attitudes) and strategies (didactic lectures, practical training and promotion of attitudes) for training programmes aimed at general practitioners. Some support materials and the promotion of an easy "4-A plan" (ask, assess, advice, assistanticipate) are suggested as contents of the training programme, whereas the learner-centred principle and the "training trainers" model are strongly recommended for the programme's design.


    1152/2523

    Tytuł oryginału: Suitability of selected markers for indentification of elements of the Intestinal Nervous System (INS).
    Autorzy: Dzienis-Koronkiewicz E[wa], Dębek W[ojciech], Sulkowska M[ariola], Chyczewski L[ech]
    Źródło: Eur. J. Pediatr. Surg. 2002: 12 (6) s.397-401, il., bibliogr. 19 poz., r‚s., res., Zsfg
    Sygnatura GBL: 312,942

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: The possibility of identifying and characterising elements of the enteric nervous system based on their contents of cathepsin D, chromogranin A, neuronal specific enolase and S-100 protein was studied in colorectal specimens (operative full-thickness, seromuscular and mucosomuscular biopsies) obtained from 15 children, aged 2 days to 10 years. Nine patients suffered from Hirschsprung's disease, and two from chronic constipation. Four neonates with imperforate anus or meconium ileus composed the control group. All markers were identified immunohistochemically by antibodies against human antigens with appropriate detection methods. Chromogranin A staining was not always adequate to identify all neuronal cell bodies and other nervous elements. However, it proved superior to the other methods in the depiction of neuroendocrine cells in the intestinal mucosa. Cathepsin D antibodies stained normal and abnormal neural cells with different intensity; nerve fibres were not stained. This marker did not allow an unequivocal differentiation of ganglion cells from macrophages within the submucosa; the latter exhibited exceptionally strong marking and in some cases represented the predominant elements in this area. Neuronal specific enolase was distinctly expressed in nerve cells and fibres of the intestinal wall. Atrophic and hypoplastic features could be identified, suggesting that this method may give some insight into functional aspects. Continuous connections between ganglions were also observed. S-100 protein antibodies resulted in a negative image of unstained ganglion cells surrounded...


    1153/2523

    Tytuł oryginału: Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine. P. 3: Synthesis and pharmacological activity of 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazol[1,2-a]imidazoles.
    Autorzy: Matosiuk Dariusz, Fidecka Sylwia, Antkiewicz-Michaluk Lucyna, Dybala Izabela, Kozioł Anna E.
    Źródło: Eur. J. Med. Chem. 2002: 37 (10) s.845-853, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 312,629

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Synthesis and pharmacological activity of 1-aryl-5,6(1 H)dioxo-2,3-dihydroimidazo[1,2-a]imidazoles (D) are presented. The title compounds were obtained from 1-aryl-2-iminoimidazolidines (1) by cyclization reaction with oxalic acid derivatives-ethyl ester (2) or chloride (3). They were tested for pharmacological activity in animal and binding assay tests. With moderate acute toxicity (LD50 ~ 200 mg kg**-1, i.p.), they exhibited significant and serotonergic activities as results of the `writhing' and the `hot plate' tests indicated, and reduced number of `head twitch' episodes after 5-HTP (5-hydroxytryptophan) administration. Reversion of the antinociception produced in the `writhing' test by small dose of naloxon (5 mg kg**-1) can suggest an opioid-like mechanism of their analgesic activity. The probable receptor inhibition mechanism of their analgesic and serotonergic activity was confirmed in the binding assay tests (by radioligand displacement) toward the opioid ć and serotonin 5-HT2 receptors. Additionally, they exhibited affinity toward the benzodiazepine (BZD) receptor as well, although in behavioral tests compounds did not produce any clear depressive effect on the central nervous system (CNS) of mice. Simple chemical structure of the title compounds, in comparison to other carbonyl derivatives of 1-aryl-2-iminoimidazolidine presented in this series of papers, underline very important role both of a hydrophobic moiety (aromatic ring) and polar groups (hydrogen-bond acceptors) in the serotonin receptor interaction. The coexistence of opioid-like, serotonergic and BZD receptor inhibition activity can be very interesting and can lead to creation of the novel group of antidepressants.


    1154/2523

    Tytuł oryginału: Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.
    Autorzy: Andrzejewska Mariola, Y‚pez-Mulia Lilian, Cedillo-Rivera Roberto, Tapia Amparo, Vilpo Leena, Vilpo Juhani, Kazimierczuk Zygmunt
    Źródło: Eur. J. Med. Chem. 2002: 37 (12) s.973-978, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 312,629

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The synthesis of several halogenated benzimidazoles substituted in position 2 with trifluoromethyl, pentafluoroethyl and 2-thioethylaminodimethyl group is reported. Antiprotozoal and anticancer activity of series of newly synthesized and previously obtained compounds was studied. All of tested bezimidazoles showed remarkable antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Of the studied collection of halogenated benzimidazoles the most anticanceractive was the 5,6-dichloro-2-pentafluoroethyl compound, particularly against breast and prostate cancer cell lines.


    1155/2523

    Tytuł oryginału: Is acute hepatitis B still a nosocomially-acquired infection in Poland? A case-controlled study of transmission routes in a hospital sample.
    Autorzy: Chlabicz Sławomir, Grzeszczuk Anna, Pytel Barbara, Prokopowicz Danuta
    Źródło: Scand. J. Infect. Dis. 2002: 34 (11) s.808-810, tab., bibliogr. 9 poz.
    Sygnatura GBL: 305,538

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • choroby zakaźne

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of this study was to evaluate the role of medically linked risk factors for acute HBV infection in the Podlasie region of North-Eastern Poland. The records of 107 adult patients and 214 age- and sex-matched controls hospitalized in the Department of Infectious Diseases, Białystok, Podlasie Region during the period 1997-2000 with the diagnosis of acute hepatitis B were reviewed. On multivariate analysis, household contact with hepatitis B [odds ratio (OR) = 18.0, 95 p.c. confidence interval (CI) 2.0 - 165.5] and a history of injections (OR = 2.7, 95 p.c. CI 1.5 - 4.7) in the preceding 6 months were independently associated with acute HBV infection. In conclusion, our data indicate that despite a significant decline in the incidence of hepatitis B, injections are still involved in the spread of HBV in Poland.


    1156/2523

    Tytuł oryginału: Synthesis and antitumor activity of novel 2-amino-4-(3,5,5-trimethyl-2-pyrazolino)-1,3,5-triazine derivatives.
    Autorzy: Brzozowski Z., Sączewski F.
    Źródło: Eur. J. Med. Chem. 2002: 37 (9) s.709-720, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 312,629

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The syntheses and antitumor activities of novel 2-amino-4-(3,5,5-trimethyl-2-pyrazolino)-1,3,5-triazine derivatives 4-38 are described. All the comppounds prepared were screened at the National Cancer Institute (NCI) for their activities against a panel of 60 tumor cell lines and relationships between structure and antitumor in vitro are discussed. The triazines 11, 16, 20, 23, 23 and 34-38 exhibited modesr or fairly high activity against one or more human tumor cell lines. Prominent compound with remarkable activity (log GI50, -80- - 5.00) to all investigated cell lines highly potent (log GI50 -8.00- - 7.64) against some cell lines of Laukemia (CCRF-CEM, K-562, RPMI-8226, SR), CNS Cancer (SF-539) and breast Cancer (T-47D) was 2-[2-amino-4-(3,5,5-trimethyl-2-pyrazolino)-1,3,5-triazin-6-yl]-3-(5-nitro-2-thienyl)acrylonitrile (25).


    1157/2523

    Tytuł oryginału: Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine. P. 2: Synthesis and pharmacological activity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-ŕ][1,3,5]triazines.
    Autorzy: Matosiuk Dariusz, Fidecka Sylwia, Antkiewicz-Michaluk Lucyna, Lipkowski Janusz, Dybala Izabela, Koziol Anna E.
    Źródło: Eur. J. Med. Chem. 2002: 37 (9) s.761-772, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 312,629

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Synthesis and pharmacological activity of 1,6-diaryl-5,7 (1H)dioxo-2,3-dihydroimidazo-[1,2-ŕ][1,3,5]triazines (C) are presented. The title compounds were obtained from 1-aryloimidazolinurea derivatives in cyclization reaction with difunctional carbonyl reagents - phosgene (method I) or carbonyldiimidazole (CDI) (method II). Their molecular structures were confirmed by the X-ray analysis of 1-phenyl-6-(4-chlorophenyl)-5,7(1H)-dioxo-2,3-dihydroimidazo[1,2-ŕ][1,3,5]triazine C2) crystals. Compounds C exhibited significant depressive action on the central nervous system (CNS) of the laboratory animals, correlated with very low acute toxicity (LD50 2000 mg kg**-1 i.p.), and showed antinociceptive activity in behavioural models. Reversion of this effect by small dose of naloxone (5 mg kg**-1) can suggest opioid-like mechanism of antinociception produced by these and other carbonyl derivatives of 1-aryl-2-iminoimidazolidine. Additionally, an effect on the serotonin neurotransmission pathway was also observed. The receptor mechanism of activity for investigated compounds was confirmed only for the opioid ć receptor in binding affinity assay test. Same tests performed for the serotonin 5-HT2 and benzodiazepine BZD receptors showed no affinity for tested compounds. The opioid-like and serotonergic activities are similar to these described earlier for chain carbonyl 1-aryl-2-iminoimidazolidine derivatives containing urea moiety, mainly due to similar chemical structure, although compounds C are not able to adopt any of the higher energy confirmations of urea derivatives...


    1158/2523

    Tytuł oryginału: Low-affinity kainate receptor-mediated events reduce the protective activity of phenobarbital and diphenylhydantoin against maximal electroshock in mice.
    Autorzy: Borowicz K. K., Zadrożniak M., Czuczwar S[tanisław] J.
    Źródło: Neuropharmacology 2002: 43 (7) s.1082-1086, tab., bibliogr. [28] poz.
    Sygnatura GBL: 305,141

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: (2S, 2R)-4-Methylglutamic acid (SYM 2081), a potent selective agonist of GluR5 and GluR6 kainate receptor subtypes, applied at the dose of 15.5 mg/kg, equal to its CD16 value (i.e., a dose required to induce convulsions in 16 p.c. of mice), significantly decreased the electroconvulsive threshold from 7.0 to 5.8 mA. When administered at the dose of 11.5 mg/kg, equal to 75 p.c. of its CD16, it markedly attenuated the protective activity of phenobarbital and diphenylhydantoin, but not that valproate, carbamazepine, or diazepam against maximal electroshock-induced seizures in mice. The respective ED50 values were increased from 18.5 to 23.8 mg/kg for phenobarbital, and from 11.7 to 14.7 mg/kg for diphenylhydantoin. Since the free plasma levels of tboth antiepileptic drugs were not influenced by SYM 2081, the pharmacokinetic interaction does not seem to be involved in the observed results. In conclusion, low-affinity kainate receptor-mediated events might be a factor reducing the protective efficacy of some anitepileptic drugs. Furthermore, the activation of GLuR5 and GluR6 kainate receptor subtypes by endogenous glutamate during seizures may be associated with the drug-resistance phenomenon.


    1159/2523

    Tytuł oryginału: Current concepts for peritoneal dialysis solutions.
    Tytuł polski: Współczesne poglądy na płyny do dializy otrzewnowej.
    Autorzy: Grzegorzewska Alicja E., Leander Magdalena
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (4) s.419-426, bibliogr. 56 poz., streszcz. - 8 Polsko-Niemiecko-Czeskie Sympozjum pt. Nowoczesne aspekty nefrologii i nadciśnienia Wrocław 23-25.05. 2002
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy przedstawiono zalety i wady stosowania niestandardowych płynów do dializy otrzewnowej: płynu zawierającego polimer glukozy (PD-PG), aminokwasy (PD-AA) oraz płynu zawierającego bufor wodorowęglanowy lub wodorowęglanowo-mleczanowy. PD-PG poprawia ultrafiltrację podczas długich wymian płynu dzięki procesowi osmozy koloidalnej. Inne korzyści stosowania PD-PG obejmują: wyższe wskaźniki adekwatności dializy, lepszy profil lipidowy surowicy, brak niekorzystnego wpływu na łaknienie i lepszą biozgodność, w porównaniu do standardowych płynów zawierających glukozę. Cechy PD-PG czynią go idealnym płynem do wczesnego rozpoczynania leczenia dializą otrzewnową, do stosowania podczas długich wymian płynu w ciągłej ambulatoryjnej lub ciągłej cyklicznej dializie otrzewnowej oraz podczas zapalenia otrzewnej. PD-AA został zaprojektowany w celu uzupełnienia przezotrzewnowych strat aminokwasów i białek, a tym samym do poprawy stanu odżywienia chorych. PD-AA nie zawiera glukozy, co jest korzystne u chorych na cukrzycę i/lub chorych otyłych. Objawy uboczne PD-AA obejmują zwiększone tworzenie się mocznika i kwasu moczowego, wzrost stężenia homocysteiny w osoczu, obniżenie stężenia wodorowęglanów w surowicy. Uważa się, że receptura PD-AA może być jeszcze ulepszona. Płyny do dializy otrzewnowej zawierające bufor wodorowęglanowy zaprojektowano w celu uniknięcia cytotoksyczności połączenia niskiego pH z mleczanami. Płyny te są wskazane u chorych cierpiących na bóle brzucha podczas wpuszczania płynu dializacyjnego, u dzieci z zespołem Leigha mających mocznicę, i ogólnie - aby poprawić jakość leczenia dializą otrzewnową...


    1160/2523

    Tytuł oryginału: Insulin-like growth factor-I receptor and its relationships to receptors for oestrogen, progesterone and epidermal growth factor in primary breast carcinoma in women.
    Tytuł polski: Receptor insulinopodobnego czynnika wzrostu-I i jego współzależności z receptorami estrogenów, progesteronu i czynnika wzrostu nabłonków w pierwotnych rakach sutka kobiet.
    Autorzy: Kluska Anna, Skasko Elżbieta, Paszko Zygmunt
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (4) s.429-435, tab., bibliogr. 19 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. Receptory hormonów steroidowych są znanymi predykcyjnymi i prognostycznymi wskaźnikami przebiegu raka sutka u kobiet. Receptory czynników wzrostu: insulinopodobnego czynnika wzrostu-I (IGF-I-R) i czynnika wzrostu nabłonków (EGF-R) mogą być również ważnymi czynnikami prognostycznymi. Cel pracy. Celem naszych badań była ocena stężenia receptora IGF-I w pierwotnych rakach sutka u kobiet oraz określenie jego korelacji z receptorami estrogenów, progesteronu i czynnika wzrostu nabłonków. Materiał i metody. W 524 pierwotnych rakach sutka kobiet oznaczono stężenie receptora insulinopodobnego czynnika wzrostu-I (IGF-I-R) oraz określono jego współzależność z receptorami estrogenów (ER), progesteronu (PR) i czynnika wzrostu nabłonków (EGF-R). Stężenia receptorów czynników wzrostu i hormonów steroidowych oznaczano techniką radioligandową. Wyniki. W badanej grupie raków sutka średnie stężenie receptora IGF-I wynosi 17,6 ń 0,9 fmol/mg białka błon. Średnie stężenie IGF-I-R w rakach kobiet miesiączkujących i po menopauzie nie różnią się między sobą znamiennie. Między stężeniami receptorów IGF-I, estrogenów i progesteronu występują dodatnie statystycznie znamienne korelacje. Zależności te, charakteryzujące się wysoką znamiennością, występują w całej badanej grupie raków, zarówno u kobiet miesiączkujących, jak i po menopauzie. Zależności między IGF-I-R i EGF-R są znamienne jedynie w grupie raków ER- i PR-ujemnych (chiý = 3,9124; p = 0,0479; Q = (+) 0,42). Wnioski. Analiza stężeń receptora IGF-I w grupach raków utworzonych ze względu na współwystępowanie w nich receptorów estrogenów i progesteronu sugeruje, że estrtogeny wywierają znacznie większy wpływ na ekspresję IGF-I-R niż progesteron.


    1161/2523

    Tytuł oryginału: Evaluation of types of cervical anastomoses in oesophageal reconstructive surgery.
    Tytuł polski: Ocena typów zespoleń szyjnych w chirurgii wytwórczej przełyku.
    Autorzy: Strutyńska-Karpińska Marta, Ciesielska Agnieszka, Błaszczuk Jerzy, Wierzbicki Jarosław, Zielony Andrzej, Taboła Renata
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (4) s.445-450, il., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. Wśród wielu czynników mających wpływ na funkcję przełyku zastępczego, właściwa średnica zespolenia szyjnego wydaje się jednym z najważniejszych. Materiał i metody. Artykuł przedstawia wyniki oceny klinicznej 2 typów zespoleń szyjnych: "koniec do końca" i "końcowo-boczno-bocznego". Analizie poddano 25 chorych obojga płci: 15 mężczyzn i 10 kobiet w wieku 24-71 lat po wykonanych operacjach wytwórczych przełyku z różnych uszypułowanych odcinków jelit. Wskazaniami do operacji były: pooparzeniowe bliznowe zwężenia w 7 i rak piersiowego odcinka przełyku w 18 przypadkach. Analiza była oparta na ocenie klinicznej, badaniach radiologicznych oraz endoskopowych. Wyniki. Funkcję zastępczego przełyku oceniono jako bardzo dobrą u 14 chorych z zespoleniem szyjnym typu "końcowo-boczno-bocznym". Średnica tego typu zespoleń wynosiła 13-16 mm. U 10 chorych, z zespoleniem szyjnym "koniec do końca" średnica zespolenia wynosiła 8-10 mm. Chorzy ci mieli niewielkie trudności w połykaniu pokarmów stałych i funkcję tego typu zespoleń oceniono jako satysfakcjonującą. U 80 proc. z nich w okresie pooperacyjnym wystąpiła przetoka zespolenia szyjnego, w wyniku której doszło do zwężenia zespolenia. U 1 chorego z zespoleniem typu "koniec do końca' na skutek pooperacyjnej przetoki zespolenia szyjnego, powstało pełne zwężenie zespolenia szyjnego co całkowicie uniemożliwiło odżywianie się przez usta. Wnioski. W naszej opinii, opartej na prezentowanym materiale chorych, zespolenie typu ...

    Streszczenie angielskie: Background. Among various factors having an influence on normal function of artificial oesophagus proper cervical anastomosis diameter seems to be one of essentials. Material and methods. The paper presents results of clinical evaluation of two types of cervical anastomoses: "end to end" and "end-side to side". We examined 25 patients of both sexes: 15 men and 10 women aged between 24 and 71 after oesophagoplaties created of various pedicle bowel segments. Indications for the operation were: postburning cicatrical stenosis in 7 cases and carcinoma of the thoracic part of oesophagus in 18 cases. Our analysis was based on clinical review, radiological and endoscopic examinations. Results. We evaluated function of the created oesophagus as very good in14 patients with "end-side to side" cervical or pharyngeal anastomoses. Diameter of these kinds of anastomoses measured between 13 and 16 mm in radiological examination. In 10 patients with "end to end" cervical anastomosis the diameter was estimated between 8 and 10 mm. These patients had little difficulties in swallowing solid food and we found the function of this kind of anastomosis satisfactory. Of them 80 p.c. developed leakage of cervical anastomosis after operation what, in our opinion, resulted in stenosis of the junction. One patient because of leakage in "end to end" anastomosis developed its complete stricture and it made oral nutrition impossible. Conclusions. In our opinion, based on presented patients, the ...


    1162/2523

    Tytuł oryginału: Breast tubular adenoma - case report.
    Tytuł polski: Gruczolak cewkowy sutka - opis przypadku.
    Autorzy: Osiecka Beata J., Bronowicz Andrzej, Ziółkowski Piotr, Rabczyński Jerzy
    Źródło: Adv. Clin. Exp. Med. 2002: 11 (4) s.513-515, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 313,451

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: W pracy przedstawiono opis przypadku gruczolaka cewkowego sutka. Nowotwór został rozpoznany u 83-letniej kobiety jako guz w lewym sutku i usunięty chirurgicznie. Gruczolak cewkowy sutka jest bardzo rzadkim nowtworem i stwarza trudności w przedoperacyjnej diagnostyce. Rozpoznanie jest oparte na badaniu histopatologicznym poprzedzanym oceną śródoperacyjną guza.


    1163/2523

    Tytuł oryginału: Tick-borne encephalitis in North-Eastern Poland in 1997 - 2001: a retrospective study.
    Autorzy: Grygorczuk Sambor, Mierzyńska Dorota, Zdrodowska Agnieszka, Zajkowska Joanna, Pancewicz Sławomir, Kondrusik Maciej, Świerzbińska Renata, Pryszmont Justyna, Hermanowska-Szpakowicz Teresa
    Źródło: Scand. J. Infect. Dis. 2002: 34 (12) s.904-909, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 305,538

    Hasła klasyfikacyjne GBL:
  • neurologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of this study was to characterize the epidemiology and clinical features of tick-borne encephalitis in North-Eastern Poland. Clinical and epidemiological data were analysed of patients hospitalized with the diagnosis in the Department of the Infectious Diseases and Neuroinfections of the Medical University in Białystok in 1997-2001. Tick-borne encephalitis was diagnosed in 152 patients: 51 (34 p.c.) presented with meningitis, 89 (59 p.c.) with meningoencephatitis and 12 (8 p.c.) with meningoencephalomyelitis. Headache (84 p.c.) and fevwer (81 p.c.) were the most common symptoms. Meningeal signs were present in 137 patients (90 p.c.). Most common neurological abnormalities were: Oppenheim and Babinski signs (74 patients, 49 p.c.), ataxia (37, 24 p.c.), impaired consciousness (37, 24 p.c.) and pareses (16, 10 p.c.). Of patients examined, 146 (96 p.c.) had raised pleiocytosis, frequently accompanied by high cerebrospinal fluid protein concentration (90 p.c.), raised erythrocyte sedimentation rate (65 p.c.), peripheral blood leucocytosis (26 p.c.) and increased aminotransferase activity (16 p.c.). There was only 1 forest worker among the patients. Tick-borne encephalitis remains common in North-Eastern Poland but, possibly because of effective vaccination, it has virtually disappeared among forest employees. The diagnosis appears difficult in some cases, as meningeal signs may not be present and laboratory findings may not be suggestive of a viral infection.


    1164/2523

    Tytuł oryginału: High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor ŕ treatment.
    Autorzy: Ziółkowska Maria, Kurowska Mariola, Radzikowska Anna, Łuszczykiewicz Grażyna, Wiland Piotr, Dziewczopolski Wojciech, Filipowicz-Sosnowska Anna, Pazdur Jacek, Szechiński Jacek, Kowalczewski Jacek, Rell-Bakalarska Maria, Maśliński Włodzimierz
    Źródło: Arthritis Rheum. 2002: 46 (7) s.1744-1753, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 305,037

    Hasła klasyfikacyjne GBL:
  • farmacja
  • reumatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca opublikowana za granicą
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Objective. To test the hypotheses that 1) proinflammatory cytokines affect osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappaB ligand (sRANKL) production and therefore the OPG and sRANKL levels differ in rheumatoid arthritis (RA) patients in comparison with healthy individuals; and 2) anti-tumor necrosis factor ŕ (anti-TNFŕ) therapy influences OPG and sRNAKL levels. Methods. Sera were obtained from healthy individuals or RA patients receiving the combination of infliximab and methotrexate. Peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) were isolated from RA patients. Fibroblast-like synoviocytes (FLS) were isolated from synovial tissue obtained at total knee replacement in RA patients. Supernatants from cells stimulated with cytokines were collected after culture in vitro. Concentrations of OPG and sRANKL were determined by enzymelinked immunosorbent assays. Results. A strong positive correlation between OPG concentration and age was observed in healthy individuals but not in RA patients. The OPG and sRANKL levels were higher in RA patients than in healthy controls. Cultured FLS spontaneously secreted much higher amounts of OPG than PBMCs or SFMCs. Proinflammatory cytokines enhanced OPG production. Anti-TNFŕ treatment resulted in the normalization of serum OPG and sRANKL levels in RA patients without influencing the OPG:sRANKL ratio. Conclusion. Although higher serum levels of OPG and sRANKL are present in RA patients than in healthy individuals, the ratio of OPG:sRANKL is similar. There is an age-dependent increase of OPG but not sRANKL levels in healthy subjects. Anti-TNFŕ treatment results in the normalization of elevated levels of OPG and sRANKL in RA patients.


    1165/2523

    Tytuł oryginału: Tetrabromobenzene induced hepatotoxicity in rats following repeated exposure.
    Tytuł polski: Ocena hepatotoksyczności tetrabromobenzenu u szczurów w warunkach ekspozycji powtarzanej.
    Autorzy: Frydrych Barbara, Czerski Jakub, Szymańska Jadwiga A.
    Źródło: Bromatol. Chem. Toksykol. 2002: 35 (3) s.231-239, il., tab., bibliogr. 17 poz., sum.
    Sygnatura GBL: 305,377

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie polskie: Polibromowane benzeny są znajdowane w środowisku i w tkankach ludzkich. Ich obecność w środowisku może być wynikiem używania heksabromobenzenu jako związku uniepalniającego oraz procesów debrominacji HBB. Celem niniejszego badania było zbadanie toksyczności podostrej jednego z metabolitów środowiskowych tetrabromobenzenu (TBB) oraz sprawdzenie jego wpływu na syntezę hemu. Zaobserwowano wzrost względnej masy wątroby oraz zmiany w poziomach sumy cytochromów. Nie zaobserwowano istotnych statystycznie zmian dla innych wskaźników toksyczności (MDA, GSH, ALAT, ç-GT). Zaobserwowano wzrost aktywności ALA-S. Nie stwierdzono natomiast silnego działania porfirogennego tego związku.


    1166/2523
    2002
    Tytuł angielski: Role of PTEN mutation in pathogenesis of pheochromocytoma : doctorate thesis
    Autorzy: Puc Janusz
    Opracowanie edytorskie: Gaciong Zbigniew (supervisor).; Akademia Medyczna Katedra i Klinika Chorób Wewnętrznych i Nadciśnienia Tętniczego w Warszawie
    Źródło: 2002, 99 k. : il., tab., bibliogr. k. 86-99, sum., maszyn.
    Sygnatura GBL: 45/19945

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • praca doktorska
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy


    1167/2523

    Tytuł oryginału: Healthy start in life : a comparison between health in Poland and Sweden with the first four WHO Health for All Targets as a starting point : doctorate thesis
    Autorzy: Pellmer-Wramner Kristina
    Opracowanie edytorskie: Drygas Wojciech (supervis.).; Medical University Department of Preventive and Social Medicine in Łódź
    Źródło: 2002, [12], 182, [5] s., [34] s. tabl. : bibliogr. s. 162-182, sum., maszyn.
    Sygnatura GBL: 45/19746

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • badanie porównawcze
  • praca doktorska
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.


    1168/2523

    Tytuł oryginału: RET proto-oncogene germline mutation in pheochromocytoma patients - incidence and clinical consequences.
    Tytuł polski: Częstość występowania i znaczenie kliniczne mutacji protoonkogenu RET u chorych z guzem chromochłonnym.
    Autorzy: Pęczkowska Mariola, Januszewicz Andrzej, Franke Gerlind, Hoegerle Stefan, Szmigielski Cezary, Łoń Izabella, Cieśla Magdalena, Janas Jadwiga, Januszewicz Magdalena, Cybulska Idalia, Wocial Bożenna, Łapiński Mariusz, Cieśla Witold, Szostek Mieczysław, Januszewicz Włodzimierz, Neumann Hartmut P. H.
    Źródło: Nadciśn. Tętn. 2002: 6 (4) s.279-284, tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 313,470

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp: Dotychczasowe badania wskazują, że częstość zespołu mnogiej gruczolakowatości (MEN 2), w skład którego wchodzi guz chromochłonny, jest większa niż dotychczas sądzono. Zespół ten dziedziczony jest w sposób autosomalny dominujący i wywołuje go mutacja protoonkogenu RET. Celem pracy jest ocena częstości występowania oraz kliniczne znaczenie mutacji protoonkogenu RET u chorych z guzem chromochłonnym. Materiał i metody: Badania genetyczne w kierunku mutacji protoonkogenu RET przeprowadzono u 106 chorcyh (średni wiek: 49 ń 14,1 roku 26M, 80K) z rozpoznanym i potwierdzonym histopatologicznie guzem chromochłonnym. Pacjenci ci byli uprzednio hospitalizowani i leczeni w Klinice Chorób Wewnętrznych i Nadciśnienia Tętniczego Akademii Med. w Warszawie w latach 1957 - 1998 oraz w Klinice Nadciśnienia Tętniczego Instytutu Kardiologii w Warszawie od roku 1980 do 2001. Oceniano również stężenie kalcytoniny (CT), zarówno w warunkach podstawowych, jak i po stymulacji pentagastryną, oraz stężenie parathormonu. Wyniki: Obecność mutacji protoonkogenu RET wykazano u 8 chorych (7,4 proc.) - w eksonie 11, w kodonie 634,TGC na CGC u 5 chorych, u pozostałych 3 odpowiednio - w eksonie 11, kodonie 634, TGC na GGC, w eksonie 11, kodonie 634, TGC na TGG oraz w eksonie 13, kodonie 791, TAT na CGC. Nadczynność komórek C potwierdzona testem pentagastrynowym stwierdzono u 5 nosicieli, u 2 chorych wynik testu był wątpliwy, jedynie u 1 chorego stężenie kalcytoniny było prawidłowe. Prawidłowe stężenie CT obserwowano u chorego z mutacją w eksonie ...


    1169/2523

    Tytuł oryginału: Georgia.
    Autorzy: Gamkrelidze Amiran, Atun Rifat, Gotsadze George, MacLehose Laura
    Opracowanie edytorskie: MacLehose Laura (ed.), McKee Martin (ed.).
    Źródło: Healt Care Syst. Transit. 2002: 4 (2) 2002 s.I-VIII, 1-72, il., tab., bibliogr. 52 poz.
    Sygnatura GBL: 554,698

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • ekonomika

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1170/2523

    Tytuł oryginału: Slovenia.
    Autorzy: Albreht Tit, Cesen Marjan, Hindle Don, Jakubowski Elke, Kramberger Boris, Petric Vesna Kerstin, Premik Marjan, Toth Martin
    Opracowanie edytorskie: Jakubowski Elke (ed.).
    Źródło: Healt Care Syst. Transit. 2002: 4 (3) s.I-VIII], 1-85, [1-4], il., tab., bibliogr. [7] poz.
    Sygnatura GBL: 554,698

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • ekonomika

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1171/2523

    Tytuł oryginału: World Health Organization : Regional Committee for Europe : report of the fifty-second session
    World Health Organization Regional Committee for Europe
    Źródło: - Copenhagen, WHO 2002, [4], 72 s., 30 cm. - Sesja Regionalnego Komitetu Europejskiego Światowej Organizacji Zdrowia Kopenhaga 16-19.09. 2002
    Sygnatura GBL: 805,601

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1172/2523

    Tytuł oryginału: Assuring availability of opioid analgesics for palliative care : report on a WHO workshop
    World Health Organization
    Źródło: - Budapest, WHO 2002, [6], 139 s. : il., 30 cm. - Warsztaty pt. Zapewnienie dostępności środków przeciwbólowych opioidowych w opiece paliatywnej Budapeszt 25-27.02. 2002
    Sygnatura GBL: 805,608

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1173/2523

    Tytuł oryginału: LDL-cholesterol and coronary artery disease: where we've been, where we're going.
    Autorzy: Sumner Andrew D.
    Źródło: Folia Cardiol. 2002: 9 (3) s.185-192, tab., bibliogr. 42 poz.
    Sygnatura GBL: 313,196

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1174/2523

    Tytuł oryginału: The polymorphism of the HERG gene responsible for the autosomal dominant long-QT syndrome.
    Autorzy: Herbert Ernest, Trusz-Gluza Maria, Moric Ewa, Śmiłowska-Dzielicka Ewa, Mazurek Urszula, Wilczok Tadeusz
    Źródło: Folia Cardiol. 2002: 9 (3) s.193-202, il., tab., bibliogr. 64 poz.
    Sygnatura GBL: 313,196

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1175/2523

    Tytuł oryginału: The Six Annual Meeting of the ESC Working Group on Echocardiography. In collaboration with the Working Group on Echocardiography of the German Society of Cardiology: [abstracts].
    Źródło: Eur. J. Echocardiogr. 2002: 3 suppl. 1 s.[9], S1-S131, il., tab. - 6 Doroczne Spotkanie Grupy Roboczej Echokardiografii Europejskiego Towarzystwa Kardiologicznego we współpracy z Grupą Roboczą Echokardiografii Niemieckiego Towarzystwa Kardiologicznego Monachium 04-07.12. 2002
    Sygnatura GBL: 313,590

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Europejskie Towarzystwo Kardiologiczne


    1176/2523

    Tytuł oryginału: IX Instructional Course Lectures of EFORT: [abstracts].
    Autorzy: Czerwiński Edward
    Źródło: J. Bone Joint Surg. Br. 2002: 84-B suppl. 3 s.349-378 - 9 Instruktażowy Kurs Wykładów EFORT [Europejska Federacja Towarzystw Ortopedycznych] Kraków 24-26.10. 2002
    Sygnatura GBL: 310,919

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1177/2523

    Tytuł oryginału: Reactive oxygen intermediates production and mannan binding lectin concentration in early pregnancy complicated by type 1 diabetes mellitus - preliminary report.
    Tytuł polski: Ocena produkcji reaktywnych form tlenu i stężenia białka wiążącego mannozę we wczesnej ciąży powikłanej cukrzycą typu 1 - doniesienie wstępne.
    Autorzy: Pertyńska-Marczewska Małgorzata, Tchórzewski Henryk, Cedzyński Maciej, Sobczak Małgorzata, Lewkowicz Przemysław, Cypryk Katarzyna, Podciechowski Leszek, Wilczyński Jan
    Źródło: Diabetol. Pol. 2002: 9 (4) s.181-185, il., tab., bibliogr. 31 poz., sum. - 3 Kongres Polskiego Towarzystwa Medycyny Perinatalnej Łódź 25-27.09. 2002
    Sygnatura GBL: 313,197

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • ciąża

    Streszczenie polskie: Układ dopełniacza odgrywa ważną rolę we wrodzonej i nabytej odpornosci. Może być on aktywowany na trzech drogach: klasycznej, alternatywnej i lektynowej. MBL (mannan-binding lectin) odgrywą ważną rolę w odporności wrodzonej. Wiele doniesień wskazuje na to, że u chorych na cukrzycę obserwuje się wzmożoną produkcję reaktywnych form tlenu (RFT) przez neutrofile krwi obwodowej. Wiadomo także, że składowe wrodzonej aktywności są aktywowane w czasie ciąży. Cel pracy. Ocena produkcji RFT oraz stęzenia MBL we wczesnej ciąży matek z cukrzycą oraz zdrowych ciężarnych. Materiał: W ocenie stężenia MBL badaną grupę stanowiło: 7 ciężarnych chorych na cukrzycę, z dobrym wyrównaniem metabolicznym między 7. a 13. tygodniem pierwszej ciąży oraz 10 zdrowych ciężarnych kobiet między 7. a 13. tygodniem pierwszej ciąży. Grupami kontrolnymi było 30 zdrowych, nieciężarnych kobiet oraz 9 nieciężarnych kobiet chorujących na cukrzycę typu 1. W celu oceny produkcji RFT przebadano 12 ciężarnych chorych na cukrzycę, pomiędzy 7-13 tygodniem ciąży. 14 zdrowych nieciężarnych, 14 chorych na cukrzycę nieciężarnych kobiet; oraz 14 zdrowych ciężarnych pomiędzy 7-13 tygodniem ciąży. W celu oceny stężenia MBL zastosowano zmodyfikowana mwetodę Aittonniemiego. Do analizy statystycznej użyto testu U Manna-Whitney'a. Produkcja ROI została oceniono metodą chemiluminescencji, przy użyciu stymulatorów fMLP, PNA, OZ oraz po 15 min. primingu TNF-ŕ. Zastosowano MLX Microtier Plate Luminometr DYNEX, USA. Wraz z programem komputerowym Revelation 97. Wyniki: 1. Zjawisko primingu...


    1178/2523

    Tytuł oryginału: The expressions of intracellular cytokines in the lymphocytes of preeclamptic patients.
    Autorzy: Darmochwał-Kolarz Dorota, Roliński Jacek, Leszczyńska-Gorzelak Bożena, Oleszczuk Jan
    Źródło: Am. J. Reprod. Immunol. 2002: 48 (6) s.381-386, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 313,270

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Purpose: The objective of the study was to investigate the intracellular expressions of T helper 1 (Th1) and Th2 cytokines in peripheral blood T lymphocytes and natural killer (NK) cells of patients with preeclampsia and women with uncomplicated pregnancy. Method of study: Blood samples were taken from 20 patients with preeclampsia and 16 healthy pregnant women. Mononuclear cells were isolated from peripheral blood and stimulated for 5 hr at 37řC and 5 p.c. CO2. Next, the cells were stained with antibodies against surface markers of T-cell subsets and NK cells. After fixation and permeabilization processes, the cells were stained with antibodies against intracellular cytokines - interleukin-2 (Il-2) and interferon-ç (IFN-ç) as well as Il-10 and Il-4. The intracellular expressions of Th1 and Th2 cytokines were determined using the flow cytometric method. Statistical analysis was performed using Mann-Whitney U-test. Results: We found that in patients with preeclampsia the expressions of Il-2 were significantly higher when compared with women with uncomplicated pregnancy. Furthermore, in the group of patients with preeclampsia the expressions of Il-2 were higher in T CD 8+ lymphocytes than in T CD4+ cells. The expressions of IFN-ç did not differ in CD4+ cells and CD8+ cells in both studied groups but they were higher in NK cells in the study group. The expressions of Il-10 were lower in lymphocytes of preeclamptic patients when compared with controls. The expressions of Il-4 did not differ in both studied groups. Conclusions: These results suggest that in patients with preeclampsia there in Th1/Th2 imbalance, with predominant Th1 immunity.


    1179/2523

    Tytuł oryginału: Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome.
    Autorzy: Randeva Harpal S., Lewandowski Krzysztof C., Drzewoski Józef, Brooke-Wavell Katherine, O'Callaghan Chris, Czupryniak Leszek, Hillhouse Edward W., Prelevic Gordana M.
    Źródło: J. Clin. Endocrinol. Metab. 2002: 87 (10) s.4496-4501, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 310,620

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Women with polycystic ovary syndrome (PCOS) have a clustering of cardiovascular risk factors, such as obesity, lipid abnormalities, impaired glucose tolerance, insulin resistance, and hypertension. Exercise is reported to lower the incidence of cardiac events. The effect of exercise on plasma homocysteine concentrations, an independent cardiovascular risk factor, has not been previously reported in women with PCOS. We examined the effects of exercise on plasma total homocysteine concentrations in young overweight or obese PCOS women [age (mean ń SD), 30.6 ń 6,6 yr; body mass index, 35.49 ń 7.57 kg/mý]. Twenty-one women consented to a 6-month exercise program; 12 women (exercisers) adhered to the program, whereas 9 (nonexercisers) did not. In both groups of women, the following parameters were recorded at baseline and 6 months: body mass index, waist-to-hip ratio, and aerobic capacity (maximal oxygen consumption); blood samples were taken after an overnight fast for plasma total homocysteine, insulin, and other biochemical parameters. A significant decrease in plasma total homocysteine concentrations (P 0.001) and waist-to-hip ratio (P = 0.041) and a significant increase in maximal oxygen consumption (P = 0.019) were recorded at 6 months, compared with baseline in the exercise group. This decrease in homocysteine was not explained by changes in anthropometric or biochemical parameters. In contrast, no significant changes in any of the variables were observed in the nonexercise group. Our study has provided the first evidence that regular exercise ignificantly lowers...


    1180/2523

    Tytuł oryginału: Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-ŕ system.
    Autorzy: Strączkowski Marek, Dzienis-Strączkowska Stella, Stępień Agnieszka, Kowalska Irina, Szelachowska Małgorzata, Kinalska Ida
    Źródło: J. Clin. Endocrinol. Metab. 2002: 87 (10) s.4602-4606, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 310,620

    Hasła klasyfikacyjne GBL:
  • immunologia
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Obesity is associated with the increased risk of cardiovascular disease; however, mechanisms responsible for such an increase are not fully understood. IL-8 is a cytokine that might have atherogenic properties. Recent in vitro studies revealed that IL-8 is produced and secreted by human adipocytes. The aim of the present study was to evaluate plasma IL-8 concentrations in obese subjects and the realationships between circulating IL-8 and anthropometric and biochemical parameters and TNF-ŕ system. A total of 75 subjects with normal glucose tolerance, 35 lean and 40 obese, were recruited for this study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test and after the euglycemic hyperinsulinemic clamp. A significant increase in plasma IL-8 was observed in the obese group. In simple regression analysis, performed for the initial evaluation of relationships, plasma IL-8 was related to body mass index, percentage of boody fat, fat mass (FM), and soluble TNF-ŕ receptor 2(sTNFR2) in the obese. In multiple regression analysis, FM, waist-to-hip ratio, gender, sTNFR2, and low density lipoprotein cholesterol were responsible for 44 p.c. of IL-8 variability. During oral glucose tolerance testing, mean plasma Il-8 concentrations increased in booth groups, whereas clamp resulted in a significant increase in plasma Il-8 only in the obese. We conclude that plasma IL-8 levels are increased in obese subjects, and are related to FM and TNF-ŕ system. Increase in circulating IL-8 might be one of the factors linking obesity with greater cardiovascular risk.


    1181/2523

    Tytuł oryginału: Schistosoma haematobium: Cytochemistry of the Mehlis gland and of the ootype wall.
    Autorzy: Moczoń Tadeusz, Świderski Zdzisław
    Źródło: Acta Parasitol. 2002: 47 (4) s.280-287, il., bibliogr. [28] poz.
    Sygnatura GBL: 303,018

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Secretory granules produced by the Mehlis' gland and by the wall of the distal ootype in Schistosomia haematobium females, were examined at the ultrastructural level by means of several cytochemical methods. Strong staining, due to a relatively high percentage of carbohydrates in the granules, was observed in polymethacrylate sections treated with a phosphotungstic acidhydrochloric acid mixture at pH = 0.5. Staining with ferric chloride-mixed-diamine mixtures (the LID and the HID reaction) showed no detectable level of oligosaccharide carboxyl and sulphate groups. A periodic acid-thiocarbohydrazide-silver proteinate reaction which was performed on epoxy sections, revealed a relatively high level of glycopyranosidic 1,2-diol groups in the granules. These results as well as the sensitivity of the secretory granules to the proteolytic action of papain indicated that the secretions produced by the Mehlis' gland and by the ootype wall were neutral glycoproteins.


    1182/2523

    Tytuł oryginału: Flow cytometric analysis of multiple myeloma cells in patients treated with high dose chemotherapy and hematopoietic stem cell transplantation : doctorate thesis
    Autorzy: Abdulnaser Ali Awedan
    Opracowanie edytorskie: Jędrzejczak Wiesław W. (superv.).; The Medical University Department of Hematology, Oncology and Internal Medicine in Warsaw
    Źródło: 2002, III, 86 k. : il., tab., bibliogr. 109 poz., sum., maszyn.
    Sygnatura GBL: 45/19975

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • praca doktorska
  • tytuł obcojęzyczny


    1183/2523

    Tytuł oryginału: Spondylo-epiphyseal dysplasia congenita Spranger-Wiedemann - a case report.
    Tytuł polski: Wrodzona dysplazja kręgów i nasad kości Sprangera-Wiedemanna.
    Autorzy: Beighton Peter, Kozłowski Kazimierz
    Źródło: Pol. J. Radiol. 2002: 67 (4) s.81-84, il., bibliogr. 5 poz.
    Sygnatura GBL: 301,279

    Hasła klasyfikacyjne GBL:
  • pediatria
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie angielskie: A case of a 6-years old boy with spondylo-epiphyseal dysplasia congenital Spranger-Wiedemann type was assessed. The major symptom was bilateral coax vara. This is the first report of this disorder in the Polish literature. In children with bilateral coxa vara the differential diagnosis includes heritable bone dysplasias, notably spondylo-metaphyseal dysplasis Sutcliffe type (comer fracture type) and sponydlo-epiphyseal dysplasia congenita Spranger-Wiedemann type. Diagnostic precision is essential for the clinical and genetic management.


    1184/2523

    Tytuł oryginału: Ketogenic diet: does acetone stop seizures?
    Autorzy: Likhodii Sergei S., Burnham W. McIntyre
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.HY19-HY24, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: The mechanism of action of the ketogenic diet, a therapy for refractory epilepsy, is unknown. Our hypothesis is that acetone, one of three ketones elevated by the ketogenic diet, is directly responsible for the diet's anticonvulsant effects. This study examined the basic concepts of this hypothesis. Material/Methods: Rats were acutely injected with acetone intraperitoneally at doses of 1 or 10 mmol/kg, or received acetone chronically in drinking water (1 p.c. v/v) for 10 days before being injected with 1 mmol/kg dose of acetone. Controls consumed regular water and were injected with vehicle. A pentylenetetrazole seizure test was administered 15 min after the injections. Following the test, acetone was measured in the cerebrospinal fluid. Results: A 10 mmol/kg injection of acetone suppressed seizures in 60 p.c. of rats (P 0.05). A chronic adiministration of acetone followed by a 1 mmol/kg injection suppressed seizures in 47 p.c. of rats (P 0.05). The acetone concentrations in these rats were 10.3 ń 2.3 and 1.0 ń 0.2 mmol/L, respectively. The effect of the acute 1 mmol/g injection (without acetone pretreatment) was not statistically significant. This dose elevated acetone to 1.1 ń 0.1 mmol/L in the cerebrospinal fluid. Conclusion: Our findings suggest that acetone is an anticonvulsant and that chronic administration may enhance its action. Linking acetone to the effects of the ketogenic diet requires further research. In particular, it will be important to confirm that the ketogenic diet generates relevang concentrations of acetone.


    1185/2523

    Tytuł oryginału: Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism.
    Autorzy: Dhossche Dirk, Applegate Heather, Abraham Ann, Maertens Paul, Bland Lorna, Bencsath Aladar, Martinez Jos‚
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.PR1-PR6, il., bibliogr. 59 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Autistic Disorder is an early-onset developmental disorder with severe lifelong impact on social functioning, communication, and behavior. There is currently no marker or cure. The pathophysiology and etiology are obscure. Evidence for abnormal gamma-aminobutyric acid (GABA) function in Autistic Disorders is limited. A few case-reports and small studies have reported differences in GABA levels in plasma, platelets, and urine, compared to controls. Further studies on abnormalities of GABA function in Autistic Disorder are warranted. Material/methods: Plasma GABA levels were measured using a new and sensitive technique, based on gas chromatography/mass spectrometry, in a small group of youngsters with Autistic Disorder and Attention-Deficit/Hyperactivity Disorder. Participants were outpatients between ages 5-15, satisfying modern criteria for these disorders. Results: Elevated plasma GABA levels were found in youngsters with Autistic Disorder. Psychotropic medications did not seem to affect plasma GABA levels in this study. Plasma GABA levels decreased with age. Conclusions: Elevated plasma GABA levels may be a biochemical marker of Autistic Disorder. This study supports the hypothesis that GABAergic mechansms play a role in the etiology or pathophysiology of Autistic Disorder. However, the hypothesis remains unspecified owing to lack of research. Future studies on the clinical associations of seizure disorders, mood disorders, and catatonia in autistic people may provide the necessary data to formulate a coherent theory of GABA dysfunction in Autistic Disorder. More trials of medication with known or suspected effects on GABA function are qarranted.


    1186/2523

    Tytuł oryginału: Recognition of substrate and Skp1 by the Homologue of Slimb (HOS) ubiquitin ligase receptor - role of the F-box.
    Autorzy: Herter Jason R., Fuchs Serge Y.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR283-BR288, il., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: SCFHOS-Rocl E3 ubiquitin ligase is an enzymatic complex, which mediates ubiquitination and subsequent proteasome-dependent degradation of phosphorylated inhibitor of NF-kappaB (IkappaB)and á-catenin. HOS is a WD40 repeats/F-box-containing protein that actually associates with the substrates and binds to Skpl1 via the F-box. Material/Methods: Here, we have studied the structural determinants of teh substrate recognition and ligase recruitment by HOS. The binding (pull-down and immunoprecipitation assays) and ubiquitination assays were perforemed in vitro with purified or partially purified recombinant proteins obtained via expression in bacteria or mammalian cells or by in vitro translation. Results: We identified specific amino acid residues (1143 and L152)) within the F-box of HOS that play a critical role in maintaining the hydrophobic interface of HOS-Skp1 interaction and found substantial similarity between interaction of Skp1 with HOS and with another F-box protein Skp2. Binding of Skp1 augments the ability of HOS to recognize the phosphorylated IkappaBŕ. Conclusions: These observations indicate teh role of teh F-box of HOS in both recruitment of ubiquitin ligase activity and substrate recognition as well as identify the structural elements that are important for both functions of HOS F-box domain. Annbreviations: HOS - Homologue of Slimb; IkappaB - inhibitor of NF-kappaB; á-TrCP - beta-transducin repeats-containing protein; SCF - Skp1-Cullin1-F-box protein complex, NMR - nuclear magnetic resonance.


    1187/2523

    Tytuł oryginału: Use of a non-contact radiant heat bandage on ischemic dermal infections in an ovine model.
    Autorzy: d'Audiffrent Alexandre, Roethle Scott, Tretinyak Alexander, Santilli Steven
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR289-BR292, il., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Background: Chronic non-healing foot wounds are common complication in the diabetic population. Local radiant heat bandage has recently been proposed as an effective adjuvant. The purpose of this study was to evaluate the efficacy of such bandage in controlling infection in an ovine ischemic wound model. Material/Methods: Bilateral flank ischemic wounds were created in a total of 42 sheep. 14 sheep were challenged with Pseudomonas aeruginosa (PA), 13 with Escherichia Coli (EC), and 15 with Methicillin resistant Staphylococcus aureus (MRSA). The left flank was designated the treatment side and the right the control side. The radiant heat bandage was applied for a total of 10 days. The animal were then euthanized and the wounds harvested for bacterial quantification. Results: 39 sheep completed the study. Mean bacterial counts were has follows: for MRSA, control 7.6 x 10**5 CFU/gm vs. heated 2.0 x 10**5 CFU/gm (p = 0.16); for EC, control 1.1 x 10**6 CFU/gm vs. heated 2.7 x 10**5 CFU/gm (p = 0.006); PA, control 1.7 x 10**6 CFU/gm vs. heated 3.9 x 10**9 CFU/gm (p = 0.001). Conclusion: Non-contact radiant bandages controls bacterial growth in ischemic wounds infected with MRSA or EC and may potentially improve wound healing. Wounds infected with PA should no be submitted to such treatment.


    1188/2523

    Tytuł oryginału: Differential expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential.
    Autorzy: Xie Suqing, Kang Jing X.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR293-BR300, il., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Hypersecretion of the precursor of the lysosomal protease cathepsin D (procatherpsin D) has been implicated in the invasive phenotype of human breast cancer. However, the mechanism of the abnormal secretion of procathepsin D remains unclear. Since the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) plays a central role in the intracellular transport and endocytosis of M6P-containing lysosomal enzymes, a deficiency in functional M6P/IGF2R may underline the hypersecretion of procathepsin D in invasive tumors. Materal/Methds: In the present study, we compared the profiles of cathepsin D and the M6P/IGF2R between the highly invasive MDA-MB-231 and the non-invasive MCF-7 cell lines. Results: MDA-MB-231 cells were confirmed to secrete a much larger proportion of procathepsin D into the medium than MCF-7 cells. Addition of M6P to the culture medium significantly altered the secretion of procathepsin D by MCF-7 cells, but had little effect on cathepsin D distribution in MDA-MB-23 cells. Both the M6P-binding capacity and the endocytosis of exogenous M6P-bearing proteins in MDA-MB-231 cells were far less than those in MCF-7 cells. mRNA analysis indicated that the levels of the M6P/IGF2R mRNA in MDA-MB-231 cells were not lower but were even higher than that in MCF-7 cells. Sequence analysis indicated a difference in the 3'-untranslated region of M6P/IGF2R between the two cell lines, but no mutation in the M6P-binding domain of the receptor. Conclusions: The results suggest that a potential defect in a post-transcriptional process (e.g., translation) may exist during synthesis of the m6P/IGF2R n MDA-MB-231 cells, leading to failure to express sufficient functional M6P/IGF2R and thereby resulting in the hypersecretion of procathepsin D...


    1189/2523

    Tytuł oryginału: Structural criteria of biologically active RGD-sites for analysis of protein cellular function - a bioinformatics study.
    Autorzy: Torshin Ivan Y.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR301-BR312, il., tab., bibliogr. 73 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Background: Cell adhesion involves interactions of integrins and extracellular proteins, often facilitated by the RGD motif. Only presence of the RGD in a sequence of a protein may be not sufficient for the biological activity (binding to an integrin) and additional biochemical and/or structural studies are essential. Material/Methods: Structural criteria that would allow identification biologically active RGD-sites on the base of a spatial structure may assist analysis of function of a protein in the cell. For the first time, computational analysis of RGD-sites in a large non-redundant set of protein structures was done. Results: out of 3819 protein chains sequences of about 100 contained RGDs. Analysis of the structures of the RGD-'native' proteins has allowed establishing main determinants of the biologically active conformations of the RGD sites: surface accessibility of the whole RGD-sequence and the secondary structure. The criteria, applied to the reamining proteins of the set, identify 23 proteins (~ 25 p.c.) with potentially active RGD-sites. The results strongly suggest that RGD has a high propensity for being involved in protein-protein interactions and this may explain occurrence of RGDs in intracellular proteins. Results of the analysis suggest (in some cases, confirm) novel integrin-related activities for 7 membrane/extracellular proteins, as well as confirm RGD-facilitated cell attachment for 5 viral proteins. Conclusions: Only presence of RGD in a sequence is not sufficient to propose biological activity of this site. The results also suggest that the method can be used on large scale: for example, for identifying potential integrin-interacting proteins in an animal genome.


    1190/2523

    Tytuł oryginału: Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins.
    Autorzy: Branes Maria C., Contreras Jorge E., Saez Juan C.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR313-BR323, il., tab., bibliogr. 58 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Background: During inflammatory responses activated polymorphonuclear cells (PMNs) adhere to each other and form clusters within the vasculature or injured tissues. We hypothesized that conditions that partially mimic the chemical environment of inflammatory foci induce the expression of functional gap junctions (GJs) between cultures PMNs. Material/Methods: Human PMNs were treated with bacterial lipopolysaccharide (LPS), TNF-ŕ, LPS plus medium conditioned by LPS-treated endothelial cells (ECs) or TNF-ŕ plus ECs conditioned medium. Gap junctional communication was evaluated with the dye coupling technique using a permeant and an impermeant GJ fluorescent dye and GJ lockers. The expression of connexins, GJ protein subunits, was evaluated by immunocytochemistry and immunoblotting. Cytochalasin-D and nocodazole were used to evalaute the involvement of cytoskeleton in the induction of dye coupling. Results: Treatment with LPS or TNF-ŕ induced the formation of PMN aggregates, but cells were not dye coupled. If the latter protocols occurred in medium conditioned by LPS-treated ECs or resting ECs, respectively, intercellular transfere only of the GJ permeant molecule was observed in most clustered cells. Dye coupling was reversibly inhibited by GJ blockers and prevented by cytochalasin-D, a microfilament disrupter, but not by noncodazole, a microtubule disrupter. Treatments that induced dye coupling also induced connexin43 and connexin40, but not connexin32 immunoreactivity. None of these connexins was detected in circulating cells. Conclusion: EC-derived factor(s) and micorofilament integrity are required for dye coupling between LPS- ane TNF-ŕ-treaated PMNs. GJ formation between PMNs is correlated with the presence of connexins43 and 40, but not 32 and requires intact microfilaments.


    1191/2523

    Tytuł oryginału: Levels of F1+2 prothrombin fragments and thrombin - antithrombin III (TAT) complexes in patients with dermatitis herpetiformis.
    Autorzy: Wankiewicz Anna, Iwan-Ziętek Iza, Gwieździński Zenon, Kotschy Maria
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR324-BR327, tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dermatitis herpetiformis (DH) is a rare bullous disease of autoimmune etiology. It is an intestinocutaneous syndrome, in which vesicopapular cutaneous lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin fragment (granular IgA deposits present at the tops of dermal papillae and IgA - EMA present in the serum). Material/Methods: The studied group consisted of 33 patients with dermatitis herpetiformis - 23 males and 10 females aged 22-78 (mean age 44.7). In all the patients, the following parameters of blood coagulation systems were determined in the plasma levels of prothrombin fragments 1+2 (F1+2), levels of thrombin - antithrombin III (TAT) complexes, antithrombin III activity (AT III). Results: In patients with dermatitis herpetiformis, the main level of F1+2 fragments amounted to 9.08 nmol/l, as compared with 1.14 nmol/l in the control group (the difference statistically significant, p 0.0001). In DH patients, the levels of TAT complexes were over twice higher than among the controls and that difference also reached statistical significance (p 0.0001). Mean antithrombin III activity (AT III) in patients with DH reached 102.60 p.c. and was similar to that observed in the control group (104.68 p.c.) Conclusions: In patients with dermatitis herpetiformis, increased levels of F1+2 prothrombin fragments and TAT complexes indicate enhanced in vivo thrombinogenesis. No statistically significant differences of F1+2 TAT and AT III levels in DH patients related to their sex, age and duration of the disease were observed.


    1192/2523

    Tytuł oryginału: Neuroprotective effect of garlic compounds in amyloid-á peptide-induced apoptosis in vitro.
    Autorzy: Peng Qiaoling, Buz'Zard Amber R., Lau Benjamin H. S.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR328-BR337, il., bibliogr. 60 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Neuronal apoptosis is one of the pathoglogical features of Alzheimer's disease (AD) and is associated with senile plaques containing amyloid-á peptide (Aá). Reactive oxygen species (ROS)are proposed to be involved in the apoptotic mechanism of Aá-mediated neurotoxicity. The purpose of this study was to determine the effects of aged garlic extract (AGE) and S-allyl cysteine (SAC) on Aá25-35-induced apoptosis and ROS generation in a rat pheochromocytoma (PC12) cell line. Material/Methods: PC12 cells were grown in RPMI 1640 medium containing 5 p.c. fetal calf serum and 10 p.c. horse serum. Cells were incubated wtih AGE or SAC for 24 h prior to exposure to Aá25-35 for various times. Cell viability, DNA fragmentation, number of apoptotic cells, caspase activity and generation of ROS were determined. Results: Aá25-35-induced apoptosis in PC12 cells was demonstrated by: 1) A dose-dependent loss of cell viability; 2) A time- and dose-dependent increase in apoptotic cells; 3) An induction of DNA fragmentation; and 4) An increase in caspase-3 activity and cleavage of poly (ADP-ribose) polymerase (PARP). After exposing PC12 cells to Aá25-35, a significant increase in ROS preeceded apoptotic events. AGE and SAC not only suppressed the generation of ROS but also attenuated caspase-3 activation, DNA fragmentation, PARP cleavage and eventually protected against Aá-induced apoptosis. Conclusions: Our data suggest that ROS may be involved in Aá-induced apoptosis in PC12 cells. They further suggest that garlic compounds can reduce apoptosis, possibly by enhancing the endogeous antioxidant defenses.


    1193/2523

    Tytuł oryginału: Activity of superoxide dismutase and catalase and the level of lipid peroxidation products reactive with TBA in patients with psoriasis.
    Autorzy: Drewa Gerard, Krzyżyńska-Malinowska Ewa, Woźniak Alina, Protas-Drozd Franciszka, Mila-Kierzenkowska Celestyna, Rozwodowska Małgorzata, Kowaliszyn Bogna, Czajkowski Rafał
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR338-BR343, tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The etiology of psoriasis, one of the most common chronic dermatoses, has not been elucidated yet. Involvement of antioxidant enzymes is suspected. The study aimed to determine the concetrations of lipid pereoxidation products reactive with thiobarbituric acid and antioxidant enzymes activity. Material/Methods: 67 patients of the Chair and Clinic of Dermatology (22 females and 45 males) with psoriasis vulgaris of 3 to 34 years' duration were examined. All were treated topically with preparations for external use. Smooth skin was treated with salicyl ointment, cignoline and tar, while salicyl oil and betamethasone diproproionide with salicylic acid was used on the scalp. Lipid peroxidation products reactive with TBA, expressed as malondialdehyde (MDA) concentration, were determined in erythrocytes using Buege and Aust method. Activities of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT), were determined in erythrocytes according to Misra and Fridovich, and Beers adn Sizer, respectively. Results: In halthy subjects, SOD and CAT activity was 1049.2 ń 261.9 U/gHb and 41.4 ń 13.7 x 10**4 IU/gHb, respectively, and MDA concentration 35.8 ń 10.5 nM/gHb. MDA concentrations in erythrocytes of psoriatic patients before treatment were 44 p.c. higher and SOD and CAT activities 20 p.c. and 27 p.c. lower, respectively, than those observed in the controls. Topical treatment improved the patients' clinical condition, resulting in slow increase of enzyme activity to values comparable with controls. Conclusions: The results confirm the involvement of antioxidant enzymes in the pathogenesis of psoriasis. It is, however, questionable whether the observed abnormalities are responsible for the onset of psoriasis, or resultant from ongoing pathologic process.


    1194/2523

    Tytuł oryginału: Patient, community and clinician perceptions of the quality of life associated with diabetes mellitus.
    Autorzy: Landy Jennifer, Stein Joshua D., Brown Melissa M., Brown Gary C., Sharma Sanjay
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR543-CR548, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: A study was undertaken to assess the quality of life of patients with type 1 and type 2 diabetes mellitus and to ascertain whether clinicians and non-diabetic respondents from the general public have similar views of the impact of diabetes upon health-related quality of life. Material/Methods: Time trade off utility values were generated from a standardized time-tradeoff questionnaire. Three hundred and fifty-two individuals with type 1 or type 2 diabetes mellitus, 157 non-diabetic participants from the general public (community), and 61 healt care clinicians participated in the study. Results: The mean utility score for diabetic patients was 0.889 and the median utility score was 1.000. The mean utility score for clinicians was 0.861, with a median value of 0.894, while the respective mean and median scores for the general public were 0.919 and 0.953. There was a significant difference between the disribution of the means of socres of clinicians and patients as well as between clinicians and the general public. There was no significant difference between the utility scores of patients and the general public. Within the group of diabetic patients, there was no significant difference in utility scores between type 1 and type 2 diabetics. Conclusions: Clinicians tended to over emphasize the impact that diabetes mellitus has on health related quality of life, while the non-diabetic publics' utility values are more closely correlated with those of diabetics themselves. We conclude that there is a significant difference in how clinicians, diabetics and the general public perceive the effect diabetes has upon quality of life.


    1195/2523

    Tytuł oryginału: Development of a site sampling form for evaluation of ED overcrowding.
    Autorzy: Weiss Steven J., Arndahl Jeanine, Ernst Amy A., Derlet Robert, Richards John, Nick Todd G.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR549-CR553, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: ED overcrowding is fast becoming a national crisis although no definition exists. The purpose of this study is to develop and pilot a sampling form that accurately reflects the concept of ED Overcrowding. Material/Methods: A 26-question site-sampling form was designed based on input from academic physicians at 11 medical schools nationwide. The study was conducted at an inner city Academic medical center. Site-samplings were conducted at 20 times over a one-week period by an independent observer. These times ranged from very slow to severely overcrowded. Information was obtained by counting patients in the waiting room, ED rooms, ED halls and registration/triage, ancillary services, the charge nurse, and the attending physicians. The charge nurse, and ED physicians rated the degree of overcrowding and the ED physician rated the feeling of being rushed. A 'combined outcome variable'was created which consisted of the average responses of nurses and physician's opinion of ED overcrowding and physician's feeling of being rushed. All other data was compared to this outcome variable. Results: Sever questions were significantly correlated with the combined outcoe variable. Tese were the number of people in the waiting room, patients awaiting triage, patients awaiting registration, full patient rooms, hallway patient, patients awaiting beds, and total registred patients. Accoridng to this scale our ED was overcrowded 20 p.c. of the time. Conclusions: This analysis clarifies the definition of overcrowding, helps indicate the variance among responses to overcrowding questions, and provides the foundation for prospective analysis of overcrowding in multiple EDs.


    1196/2523

    Tytuł oryginału: Incidence of complications of peptic ulcers in patients with Helicobacter pylori (Hp) infection and/or NSAID use in the era of Hp eradication.
    Autorzy: Bobrzyński Andrzej, Bęben Piotr, Budzyński Andrzej, Bielański Władysław, Płonka Małgorzata, Konturek Stanisław J.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR554-CR557, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hp and NSAID are considered as major pathogens in peptic ulcerations and their complications but little is konwn about the incidence of ulcaers and their complications following widespread use of Hp eradication. The aim of the study were: 1) to analyze incidence of ulcers and their complications, bleeding and perforations at time when the HP eradicaton has been used in ulcer therapy, and 2) to assess the impact of Hp infection and NSAID use on the incidence of ulcers and complications. Material/Methods: From 1996 to 2001, 381 patients with complications of peptic ulcers were admitted to the emergency surgery, including 273 patients with bleeding ulcers and 108 with perforations out of a sample of 6515 dyspeptic patients examined with upper endoscopy and 13C-urea breath test (UBT). Results: The rate of ulcer bleeding and perforations, remained relatively constant throughout the study period. NSAID use in that group increased form 15.8 p.c. in 1999 to 19.3 p.c. in 2001. The incidence of HP in patients with complications assessd by UBT or CLO was 76.7 p.c., while the incidence of Hp in 7920 patients ranged form 72.8 p.c. in 1996 to 53.8 p.c. in 2001. There were 1940 (29.7 p.c.) patients with duodenal and/or gastric ulcer diagnosed by upper gastroscopy. The decline in the prevalence of peptic ulcer from about 44 p.c. to 8 p.c. occurred over the same time. A slight increase in the number of ulcer resulting from NSAID use was observed so was the number of ulcers without Hp or NSAID (idiopathic). Conclusions: Despite decreased Hp prevalence, the incidence of ulcers complications remained unchanged probably due to increased use of NSAID and the appearance of idiopathic ulcers.


    1197/2523

    Tytuł oryginału: Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk.
    Autorzy: Ye Zheng, Parry James M.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR558-CR565, il., tab., bibliogr. 47 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Rapid NAT2 acetylation has been considered as a risk factor for developing colon cancer in a number of studies, however the overall results of such studies are inconsistent. To clarify the influence of NAT2 rapid acetylation status on colon cancer risk, we have performed a metaanalysis of 20 published case-control studies (4431 cases, 4547 controls). Material/Methods: Odd ration was employed to evaluate the risk of colon cancer and NAT2 rapid acetylation status. To take into account the possibility of heterogeneity across the studies a statistical test for heterogeneity across the studies was performed. The summary odds ratios were assessed by calculating a weighted average of odds ratios for all of the studies. Results: The pooling of studies based on phenotyping methods indicated that the overall odds ratio of colon cancer risk associated wtih rapid acetylator was 1.51 (95 p.c. Cl: 1.07 - 2.12). However, the risk of colon cancer associated with rapid acetylator from the studies based on genotyping method was lower with a calculated overall odds ratio of 1.06 (95 p.c. Cl: 0.97 - 1.15). Pooling studies were also conducted on specific tumour sites and ethnic groups. The results show that effect of rapid acetylator on colon cancer risk was not obviously different. Conslusions: The results of our meta-analyses do not support the hypothesis that NAT2 alone is an important risk factor for colon cancer and suggests that NAT2 rapid acetylation status has no specific effect on the risk of developing colon cancer.


    1198/2523

    Tytuł oryginału: Angiotensin I-converting enzyme insertion/deletion polymorphism and adrenergic response to exercise in hypertensive patients.
    Autorzy: Jalil Jorge E., Córdova Samuel, Ocaranza Maria Paz, Schumacher Erwin, Braun Sandra, Chamorro Gastón, Fardella Carlos, Lavandero Sergio
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR566-CR571, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The inserton/deletion ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce divrse adrenergic responses to physiological stimuli. The aim of this study was to evaluate the influence of the ACE I/D polymorphism on the adrenergic response to isotonic exercise in middle-aged hypertensive patients. Material/Methods: Submaximal exercise (on a treadmill, using the Naughton protocol at 75 p.c. of maximal heart rate) was performed in 34 patients homozygous for the ACE I/D polymorphism (ACE II and ACE DD) with untreated essential hypertension (II = 19, DD = 15). Plasma venous adrenaline and noradrenaline were measured at rest and at submaximal exercise. Results: Plasma ACE activity was significantly higher inthe hypertensive patients carrying the ACE DD genotype compared with the ACE II group. Left atrium size, as well as LV dimensions, mass, and function, were similar in both gorups. Total exercise time, baseline and 75 p.c. maxmal heart rate (MHR) and blood pressure were similar in both groups. Baseline plasma adrenaline and noradrenaline levels were similar in both gorups and increased significantly (p 0.05) by ca 300 p.c. at submaximal exercise without differences between groups. Conclusions: The presence of the D allele on the ACE gene in middle-aged hypertensive pateints determines higher circulating ACE activity but not increased sympathetic activity in response to submaximal exercise.


    1199/2523

    Tytuł oryginału: Epidemiological surveillance of pediatric Hodgkin's disease in southern Iran.
    Autorzy: Karimi Mehran, Yarmohammadi Hooman, Ghavanini Ahmad A., Kumar Perikala V.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR572-CR575, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: To study the epidemiological pattern of Hodgkin's disease (HD) in children of Southern Iran, a total of 120 cases of biopsy-proven Hodgkin's disease, less than 18 years old, submitted for histological diagnosis during 1987 - 1997 were classified, using the Rye's Classification. Material/Methods: Data on age, sex, number in households, socio-economic status, clinical presentation, signs and symptoms, para-clinical data at the time of diagnosis, treatment plan, recurrence and the presence of metastases were derived from the patients' history, and analyzed. Results: The largest subgroups were those of Mixed celularity (66.7 p.c.), followed by Nodular sclerosis (23.3 p.c.), Lypmpocytic predominance (8.3 p.c.) and Lymphocytic depletion (1.7 p.c.). The male-to-remale ratio was 2.87. Patients with Nodular sclerosis were generally older than those in other groups. The mean age in all histopathological classes was higher in females. Conclusion: The epidemiological pattern of the HD in southern Iran is similar to that of other developing countries and the northern part of Iran, in which mixed callularity is the most common subtype. However, this pattern differs from the pattern seen in the United State and Europe, since Nodular sclerosis is the most common subtype in these regions.


    1200/2523

    Tytuł oryginału: Role of semantic control of action in the comprehensive rehabilitation of patients recovering from prolonged post-traumatic coma.
    Autorzy: Pąchalska Maria, Talar Jan, MacQueen Bruce Duncan
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR576-CR586, il., tab., bibliogr. 44 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • neurologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Apraxia, broadly understood as the acquired inability to perform learned, skilled movements not caused by paresis or incomprehension, occurs with greater frequency among patients' recovering from prolonged post-trauamtic coma than has previously been reported. The present article prevents an evaluation of the effectiveness of a rehabilitation program called Semantic Priming, aimed at rebuilding praxis in the patients. Material/Methods: Out of a consective series of 51 patients with post-traumatic coma lasting longer than 4 weeks treated at the centers represented by the authors, 24 were found to have pathological scores on the Boston Test of Praxis. These patients were divided into two matched groups, of wom the experimental group received the Semantic Priming program (involving the systematic use of verbal cues to prime movement activation patterns), and the control group did not. Progress was measured by the Boston Test of Praxis and a test developed by the authors on the basis of Luria's procedure for testing praxis. Results: After 5 weeks of therapy the patients in the experimental gorup showed significantly greater improvement in all measured parameters (p 0.001). Conclusions: Apraxia in the broader sense is a more common problem among post-coma patients than heretofore recognized, and causes concrete problems in rehabilitation and adjestment to daily living. Our program based on the use of semantic priming of activation proved to be highly succesful in remediating apraxia in these patients.


    1201/2523

    Tytuł oryginału: Incidence of childhood cancers in Poland in 1995-1999.
    Autorzy: Kowalczyk Jerzy R., Dudkiewicz Ewa, Balwierz Walentyna, Bogusławska-Jaworska Janina, Rokicka-Milewska Roma
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR587-CR590, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The annual rate for childhood cancers in developed countries amonunts to 105 - 130 new cases per 1 milion children. The Polish population aged 0 - 17 years is estimatd at approximately 10 milion children and adolescents, thus ca. 1100 - 1300 new cases can be expected every years. In 1995, we started a national childhood cancer registry. Material/Methods: information on the new diagnoses of childhood cancers was collected in 11 regional centers and submitted to the national center in Lublin. All data were verified carefully and standardized incidence rates were calculated. Results: In 1995, we registserd 1028 newly diagnosed malignant neoplasms, in 1996 and 1997 - 1036 cases, in 1998 - 1007, and in 1999 - 1158 new cases. The estimated incidence rates were: 102.3; 109.5; 111.9; 111.6 and 118.3 per 1 milion children, respectively. The most frequent childhood cancers include feukemia, which accounts for 28 p.c. of cancer cases, lymphoma (14.3 p.c.) and C. N. S. tumors (16.3 p.c.). Conclusions: Neoplasms of the hematopoietic system (leukemias and lymphomas) account for about 42 p.c. of all childhood cancers. Malignant lymphomas, bone tumors and germinal tumors are more frequently diagnosed in Poland, but the incidence of central nervous system tumors is lower than in other countries.


    1202/2523

    Tytuł oryginału: Clinical and epidemiological assessment of hepatitis C virus infection among voluntary blood donors.
    Autorzy: Łabędzka Hanna, Simon Krzysztof, Gładysz Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR591-CR596, tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: This study analyzes the clinical and epidemiological characteristics of patients infected with hepatitis C virus (HCV), with emphasis on differences between voluntary multiple blood donors, first time blood donors, and non-donating patients with chronic or acute hepatitis C. Material/Methods: Our epidemiological and clinical assessment covered 119 voluntary blood donors, as well as 92 HCV patients and were seen in the same hosptal. Results: A variety of potential HCV transmission routes variety was demonstrated in both examined groups. The main infection routes were associated with diagnostic and therapeutic procedures performed in medical service units. Substantial time divergence was found between probable HCV infection and onset of first symptoms suggesting liver pathology or HCV antibody detection. No subjects from either groups showed specific symptoms pointing univocally at liver disease. Hepatomegaly was the most common symptom observed on physicial examination. No pathology of other organs which could possibly be associated with HCV infection was found in any patient. Increased aminotransferase activity was found in over 40 p.c of the donors, and over 90 p.c. of the non-donating patients on first examination. Liver biopsy histological assessment delivered the most reliable information concerning the degeree of liver pathology degree, which was slight in most cases. Conclusions: Multiple voluntary blood donation does not influence the clinical picture and sourse of HVC infection, not does it not increase the risk of HCV infection.


    1203/2523

    Tytuł oryginału: G-protein á3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus.
    Autorzy: Dzida Grzegorz, Golon-Siekierska Patrycja, Puźniak Andrzej, Sobstyl Jacek, Biłan Andrzej, Mosiewicz Jerzy, Hanzlik Janusz
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR597-CR602, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Diabetes mellitus type 2 results from a complex of hreditary and environmental factors. Genes encoding elements of the G-protein system are candidate genes in hypertension and obesity. Since insulin uses G-sensitive mechanisms to enhance tissue glucose uptake and vasodilatation, the GNB3 gene may be a candidate gene in type 2 diabetes. The goal of our research was to determine if the C825T polymorphism at the G-protein á3 subunit gene locus is associated wtih type 2 diabetes. Material/Methods: The study population consisted of 172 Polish patients with type 2 diabetes and 172 healthy, age- and sex-matched controls. The C825T polymorphism was detected by PCR and RFLP. Results: A higher frequency of genotypes containing the mutation (CT + TT) was observed among the diabetics than in the controls. The T825 variant occurred more often among hypertensive daibeatics (71 p.c.) than among diabetics with normal blood pressure (42.5 p.c.). The OR for hypertension in diabetic subjects bearing CT + TT genotypes was higher than in patients with the CC genotype. Overweight and obesity were not associated with teh T825 variant in either the experimental subjects or the controls. Conclusions: In this population, the T825 variant of the GNB3 gene was not associated withtype 2 diabetes itself, nor with overweight and obesity, but was associated with diabaetic hypertension. Upon confirmation of our results this variant may be useful as a genetic marker of susceptibility to hypertension and vascular complications in type 2 diabetes.


    1204/2523

    Tytuł oryginału: Angiotensin I-converting enzyme and chymase gene polymorphisms - relationship to left ventricular mass in type 2 diabetes patients.
    Autorzy: Gumprecht Janusz, Zychma Marcin, Grzeszczak Władysław, Łącka Beata, Burak Wacław, Mosur Mariusz, Kaczmarski Jacek, Otulski Ireneusz, Stokłosa Tomasz, Czank Piotr
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR603-CR606, tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Type 2 diabetic patients are at increased risk for cardiovascular morbidity and mortality. Increased left ventricular mass also predicts a higher incidence of cardiovascular events. Angiotensin II is a potent mediator of myocardial growth, and angiotensin II can be produced in the heart by angiotensin I-convertig enzyme (ACE) and heart chymase (CMA). The aim of this study was to establish the role of ACE gene insertion/deletion (I/D) and CMA gene CMA/B polymorphisms in determining left ventricular mass in type 2 dibetic patients. Material/Methods: Echocardiographic measurements, ACE gene I/D and CMA/B genotypes were determined in 154 type 2 daibetic patients. Results: Mean LVMI was higher among DD homozygotes compared to heterozygotes and II homozygotes (128.9 g/mý vs. 120.5 g/mý and 120.4 g/mý, respectively), but the difference was not statistically significant (ANOVA P = 0.12). A similar effect was observed for the CMA/B polymorphism, where mean LVMI were 126.6 g/mý, 122.1 g/mý adn 118.2 g/mý, for carriers of AA, AG and GG genotype, respectively (not statistically significant, P = 0.33). ACE I/D adn CMA/B polymorphism were also analyzed jointly, and carriers of both DD and AA genotypes were found to have significantly higher LVMI values (P = 0.05) than non-carriers (133.0 g/mý and 121.2 g/mý, for 21 DD and AA carriers vs. 133 non-carriers). In multivariate analysis, the presence of DD and AA genotpyes was independently associated with LVMI (P = 0.04). Conclusion: Our results may suggest the additive effect of ACE and CMA gene polymorphisms on the increase in left ventricualr mass in NIDDM patients.


    1205/2523

    Tytuł oryginału: T-helper (1) cytokines increase during early pregnancy in women with a history of recurrent spontaneous abortion.
    Autorzy: Rezaei Abbas, Dabbagh Ali
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR607-CR610, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Background: The measurement of various cytokines may provide different tools for evaluation of the immune system. The objective of this study was to access the role of the Th1 cytokines (IL-2, IFN-ç, TNF-ŕ, TNF-á) in this phenomenon, and detection of Th1 cytokines in women with RSA. Material/Methods: The control group consisted of 40 women with no history of pregnancy loss. The abortion group comprised of 92 women having at least 3 pregnancy losses. Blood samples from the control group and women with RSA were taken at the end of first trimester of gestational age and at the time of abortion, respectively. Sera were separated and lymphocytes were chalenged with PHA. All samples were tested for concnetration of Th1 cytokines using ELISA methods. Results: It was found that sera from women with RSA produce higher concentration of TNF-ŕ, TNF-á, and IL-2 in comparison with sera from normal pregnant women (NPW) (P 0.001). We were not able to detect IL-2 in (NPW) whereas in 31 p.c. sera from RSA group. IL-2 was detectable (P 0.001). However, there was no significant differences between IFN-ç, concentration in sera from patients and control group (P 0.182). Tissue culture supernatant from women with RSA also produced higher concentration of RNF-ŕ, IFN-çm TBF-á and IL2, than control group. Conclusions: These data may explain the increase NK-cells cytolytic activity during early pregnancy in RSA group. It may also provide a diagnostic tool to predict the outcome of pregnancy.


    1206/2523

    Tytuł oryginału: Fractal characteristics of brain vessel microangioarchitecture during the fetal period.
    Autorzy: Rybaczuk Marek, Kędzia Alicja, Paradowski Leszek
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.MT145-MT152, il., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Background: Studies of human telencephalon during the fetal period are rare. Recent technologies, such as the Pickworth method, ultraviolet, infrared, and computer image systems, now enable the observation of such barely accessible structures. The present study constitutes an evaluation of the microangioarchitecture of brain vessels during the fetal period and the creation of a fractal model to describe it. Studies formulated in the language of fractals have never previously been applied in modeling brain vessels. Material/Methods: We studied 100 brains in the 4th to 86h month of fetal life, using the Pickworth method, computer image analysis under three different systems, the POV-RAY program, and fractal analysis. Results: The POV-RAY program was used to generate 3-dimensional, tree-like structures. This requires three scaling parameters: length, vessel diameter, and the angle between the branches and the central axis. The vessel structure was modeled by fractals with condensation point. Moreover, these tree-like fractals have different one-sided dimensions. In making fractal models we treated these one-sided dimensions as numerically evaluted parameters of the theory. Of course, the accuracy of the proposed models depends upon the accurate prediction by a fractal of the examined structure. Conclusions: Brain vessels can be modeled with the help of fractals with condensation points, which have differentiated one-sided dimensions.


    1207/2523

    Tytuł oryginału: Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide.
    Autorzy: Członkowska Anna, Kurkowska-Jastrzębska Iwona, Członkowski Andrzej, Peter Doris, Stefano George B.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.RA165-RA177, il., bibliogr. 174 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: It has been known for many years that immune system alterations occur in Parkinson's disease (PD). Changes in lymphocyte populations cerebrospinal fluid and blood, immunoglobulin synthesis, and cytokine and acute phase protein production have been observed in patients with PD. In this regard, PD patients exhibit a lower frequency of infections and cancer, suggesting that immune system stimulation may occur. This hypothesis is further supported by the observation of T-cell activation leading to the production of interferon ç in PD. As in other CNS degenerataive diseases, in damaged regions in the brains of PD patients, there is evidence of inflammation, characterized by glial reaction (especially microglia), as well as increased expression of HLA-DR antigens, cytokines, and components of complement. These observations suggest that immune system mechanisms are involved in the pathogenesis of neuronal damage in PD. The cellular mechanisms of primary injury in PD have not been clarified, however, but it is likely that mitochondrial mutations, oxidative stress and apoptosis play a role. Furthermore, inflammation initiated by neuronal damage in the striatum and the substantia nigra in PD may aggravate the course of the disease. These observations suggest that treatment with anti-inflammatory drugs may act to slow progression of PD.


    1208/2523

    Tytuł oryginału: Nitric oxide and pulmonary circulation.
    Autorzy: Clini Enrico, Ambrosino Nicolino
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.RA178-RA182, bibliogr. 54 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of this review is to outline the characteristics of pulmonary circulation in health and disease and to define the value of exhaled NO (eNO) as a means to assess the involvement of pulmonary cirulation in pathology. The discovery of the endocrine role of the endothelium has generated great interest in its potential role in regulating the vascular tone of the pulmonary vascular bed. Nitric oxide (NO)-mediated, endothelium-dependent relaxation has been demonstrated in the pulmonary arteries of animals and humans. Changes in the NO pathway in pulmonary hypertension are not completely understood. It is clear that NO has an important role in modulating the response to acute hypoxia, increased flow, and shear stress. The amount of exhaled NO (eNO) in different species may be easily measured, reflecting the overall NO metabolism from the lung (thus including epithelial, endothelial and other cell activity). The development of pulmonary hypertension secondary to systemic (systemic sclerosis, chronic heart failure) or pulmonary (COPD) diseases appears to be associated with a decrease in NO production both at rest and during exercise. Chronic inhalation of NO appears to protect against pulmonary hypertension in animal models. Exhaled no is attracting interest for its in vivo ability to represent the features of pulmonary circulation in pathology.


    1209/2523

    Tytuł oryginału: Three-dimensional structure and molecular mechanism of novel enzymes of spore-forming bacteria.
    Autorzy: Jedrzejas Mark J.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.RA183-RA190, il., bibliogr. 38 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Bacillus and Clostridium species are spore-forming bacilli that cause serious diseases in livestock and in humans. An important pathogen in this group of organisms is Bacillus anthracis is which is the causative agent of anthrax. The biochemical properties, structure, function, and mechanism of catalysis of the novel spore germination protease (GPR) that degrades small, acid soluble proteins (SASP) protecting spore's DNA against damage and a novel, cofactor independent phosphoglycerate mutase (iPGM) are described. A coat created from SASP synthesized during sporulation protects DNA in spores and later in the germination this protective coat is removal by a novel GPR protease. GPR does not resemble in its structure any other known protein and functionally likely belongs to a novel class of proteases utilizing glutamic acid residue in its catalysis in order to degrade SASP. This process provides amino acids necessary for synthesis of other proteins or enzymes necessary in vegetative state. In addition during the spore creation process energy is stored in the form of 3-phosphoglycerate by downregulating a novel, diphosphoglycerate independent iPGM. These depots of energy are utilized later by the germinating spore in addition to the above source of amin acids. The two above enzymes are inherently involved in the processes of sporulation, spore germination and outgrowth. A combination of structural investigations and site-directed mutagenesis studies that were used to characterize the functional properties and the active sites of these novel proteins will be discussed. The understanding of...


    1210/2523

    Tytuł oryginału: Critical appraisal of facet joints injecitons for chronic whiplash.
    Autorzy: Kwan Oliver, Friel Jon
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.RA191-RA194, bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Whiplash has been defined as an injury mechanism, an injury, a medicolegal and social dilemma, and a complex chronic pain syndrome. The chronic whiplash syndrome has long been a source of controversy, in large part because most patients do not have any readily identifable injury in either the acute or chronic stage. Many sites of patholog have been postulated over the years, but all have thus far been unsubstantiated by objective research evidence or have been shown in controlled studies to be no more prevalent in injured than in uninjured subjects. Recent promise has been afforded to the possibility of acute facet joing injury in the cervical spine and chronic pain arising from the facet joint. Despite the great appeal of this notion, however, there are considerable methodological and epidemiological barriers to its acceptance, and thre remains a paucity of research to date to advance this theory. In this review, we examine the clinical studies which have identified facet joint pain in whiplash patients and have examined the diagnosis of the same via facet joint blocks and treatment via radiofrequency neurotomy. We conclude that this therapy should not be used until more credible and scientific evidence arises from further study.


    1211/2523

    Tytuł oryginału: Ludwik Hirszfeld: a life in serology.
    Autorzy: Schneider William H.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.355-359, il.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Hirszfeld
  • Ludwik 1884-1954


    1212/2523

    Tytuł oryginału: Ludwik Hirszfeld (1884 - 1954): a personal memoir.
    Autorzy: Balińska Marta Aleksandra
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.361-353
    Sygnatura GBL: 304,223

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Hirszfeld
  • Ludwik 1884-1954


    1213/2523

    Tytuł oryginału: Predicting outcome in hematological stem cell transplantation.
    Autorzy: Dickinson Anne M., Cavet James, Cullup Hannah, Wang Xiao N., Jarvis Mark, Sviland Lisbet, Middleton Peter G.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.371-378, il., tab., bibliogr. 62 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-ŕ, IFN-ç, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell trasplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest than certain cytokine gene polymorphisms may be associated with more severe disease.


    1214/2523

    Tytuł oryginału: Structures and serology of the O-specific polysaccharides of bacteria of the genus Citrobacter.
    Autorzy: Knirel Yuriy A., Kocharova Nina A., Bystrova Olga V., Katzenellenbogen Ewa, Gamian Andrzej
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.379-391, il., tab., bibliogr. 81 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The review presents the structures of the O-spcific polysaccharides (O-antigens) of the lipopolysaccharides isolated from over 25 Citrobacter strains, which represent different species and serogroups. The correlation between O-antigen structure and immunospecificity as well as numerous cross-reactions between Citrobacter and other enterobacterial species are discussed.


    1215/2523

    Tytuł oryginału: Streptomyces and Escherichia coli, model organisms for the analysis of the initiation of bacterial chromosome replication.
    Autorzy: Messer Walter, Zakrzewska-Czerwińska Jolanta
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.393-398, il., bibliogr. 37 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Streptomyces coelicolor A3(2) and Escherichia coli are quite different in their life-style and the structures of their genomes. Streptomyces exhibit complex multicellular development including formation of multigenomic hyphae during growth. These organisms possess a large linear (8.7 Mb) and GC-rich (~72 p.c.) chromosome. The genome sequence of S. coelicolor has just been completed. The difference between E. coli and Streptomyces making them an excellent model organisms for a comparison of their replication modes. In this review, we compare initiation of chromosome replication in both organisms. Their replication origins are different in size, but both have DnaA boxes - a binding motifs for initiator DnaA protein. The two DnaA proteins have practically the same biochemical properties. Many aspects of the control of initiation seem to be similar. A comparison of the two systems thus allows us to define those aspects of replication initiation that are universally used in the eubacterial kingdom.


    1216/2523

    Tytuł oryginału: Lactoferrin and immunologic dissonance: clinical implications.
    Autorzy: Kruzel Marian L., Zimecki Michał
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.399-410, il., tab., bibliogr. 84 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • in vitro

    Streszczenie angielskie: Homeostasis is the maintenance of equilibrium in a biological system by means of positive and negative feedback control mechanisms that counteract influences tending toward physiological dissonance. At the molecular level, homeostasis is controlled by the network of the neuro-endocrine-immune system, in which lactoferrin (LF) plays a central role. The purpose of this review is to provide a comprehensive summary of a collaborative study established between the Hirszfeld Institute of Immunology and Experimental Therapy (Wrocław, Poland) and the University of Texas Helth Science Center (Huston USA) regarding LF and its role in homeostasis. In our studies we focused on the immunoregulatory functions of LF, both in vitro and in vivo. We investigated the immune status of individuals subjected to different isults, including experimental endotoxemia in mice and surgery in humans. We also studied a LF-dependent delayed type hypersensitivity (DTH) response to evaluate some of the mechanisms by which LF can effectively substitute an adjuvant in vaccine.


    1217/2523

    Tytuł oryginału: Experimental therapies for psoriasis.
    Autorzy: Asadullah Khusru, Volk Hans-Dieter, Friedrich Markus, Sterry Wolfram
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.411-420, il., tab., bibliogr. 46 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: There is a high medical need for better therapies for psoriasis. Based on new insight into the pathophysiology of this frequent immune disease, a number of novel systemic immunomodulatory therapies are currently in clinical developmet. These include approaches targeting antigen presentation and costimulation, T cell activation and leukocyte adhesion, action of proinflammatory mediators, and modulating the cytokine balance. Although mainly only preliminary data are available so far, these trials contribute to a further understanding of the disease and will eventually lead to new therapeutic options for psoriasis. Moreover, since psoriasis can be considered as a visible model disease for T cell-mediated disorders characterized by a type 1 cytokine pattern in general, such approaches may have impact for other immune disorders as well. Here we review the rationale and the initial clinical data of these important recent experimental therapies.


    1218/2523

    Tytuł oryginału: Diminished expression of the type II receptor for TGFá (TGFáRII) in T lymphocytes from patients with sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches.
    Autorzy: Zhang Qian, Capocasale Renold J., Fox Floyd E., Bedian Vahe, Vonderheid Eric C., Rook Alain, Moore Jonni S., Nowell Peter C., Haines Dale S., Wasik Mariusz A.
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.421-429, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • genetyka
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Perihperal blood lymphocytes from patients with Sezary syndrome (SzS) frequently demonstrate decreased surface expression of transforming growth factor á receptor II (TGFáRII). The mechanism of this low TGFáRII expression remains unknown. Because mutations within the poly-A tract of the TGFáRII sequence (nucleotides 709 - 718) were shown to result in diminished TGFáRII expression in other types of malignant tumors, we examined the sequence of the TGFáRII poly-A tract in two SzS-derived cell lines and in peripheral blood SzS cells from 17 SzS patients and 4 control, healthy individuals using DNA sequencing and single-stranded conformation polymorphism (SSCP) analysis. A standard bidirectional, automated sequence analysis of the RT-PCR-generated cDNA TGFáRII fragment showed a heterogenous population of the normal length, 10-, with admixed, shortened, 9-base poly-A stretches. Surprisingly, this mixture was present not only in the cells from 5 SzS patients and 2 SzS cell lines, but also in cells from 2 healthy control individuals. Importantly, the proportion of the shortened, 9-base fragments was markedly reduced or practically eliminated when the procedure was modified by usage of high-fidelity DNA polymerase, labeled primers and/or cloned RT-PCR products, which indicates that the presence of the shortened, 9-base fragments represented a procedural phenomenon rather than a true deletional mutation within an allele of the TGFáRII gene. Accordingly, SSCP analysis of genomic DNA did not reveal any mutations within the poly-A tract-containing region. These results indicate ...


    1219/2523

    Tytuł oryginału: In vivo changes in the intestinal lipid peroxidation and the crypt response to whole-body gamma irradiation in diethylnitrosamine-treated mice.
    Tytuł polski: Zmiany in vivo w peroksydacji lipidów oraz odpowiedzi krypt jelitowych myszy napromieniowanych na całe ciało promieniowaniem gamma po zatruciu nitrosodietyloaminą.
    Autorzy: Grudziński Ireneusz P.
    Źródło: Rocz. Państ. Zakł. Hig. 2002: 53 (4) s.333-340, il., bibliogr. 33 poz., streszcz.
    Sygnatura GBL: 301,906

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • radiologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie polskie: Przeprowadzono badania w celu analizy peroksydacji lipidów oraz przeżycia krypt w błonie śluzowej jelita cienkiego myszy zatruwanych per os N-nitrozodietyloaminą (DENA) (o.01, 0.1, or 1.0 mg kg/m.c) przez okres 21 dni oraz napromieniowanych na całe ciało (2.5, 5.0, 7,5, or 10.0 Gy) promieniowaniem gamma po ekspozycji an DENA. Myszy otrzymujące per os fizjologiczny roztwór chlorku sodowego (0.9 proc. NaCl) stanowiły kontrolę w doświadczeniu. Rezultaty wykazały, że DENA obniża letalną dawkę promieniowania gamma dla komórek krypty jelitowej oraz zwiększa wrażliwość krypt na promieniowanie gamma. Obecne wyniki sugerują, że pro-oksydacyjne oddziaływanie DENA i/lub promieniowania gamma jest czynnikiem ryzyka dla przeżywalności krypt jelita cienkiego.


    1220/2523

    Tytuł oryginału: NoiseChem: an European Commission research project on the effects of exposure to noise and industrial chemicals on hearing and balance.
    Autorzy: Prasher Deepak, Morata Thais, Campo Pierre, Fechter Lawrence, Johnson Ann-Christin, Lund Soren Peter, Pawlas Krystyna, Starck Jukka, Sułkowski Wiesław, Śliwińska-Kowalska Mariola
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.5-11, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Exposure to multiple physical and chemical agents is common in occupational environments but workplace hazards and occupational safety critieria for combined exposures are lacking. NoiseCHem is an European Commision research project examining the effects of exposure to noise and chemicals on hearing and balance. Partners in Sweden, Finland, France, Denmark, UK and Poland with expert guidance from partners in the USA will examine workrers and study the mechanisms of action in animals to determine the levels of risk associated with joint exposure to noise and solvents. This paper biriefly outlines the project details.


    1221/2523

    Tytuł oryginału: Identification and assessment of work-related nervous system lesions.
    Autorzy: Langauer-Lewowicka Henryka
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.13-17, bibliogr. 22 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Short historical data on occupational neurotoxicology, as well as on the pathogenic mechanisms of the nervous system impairments due to occupational factors are descirbed. The main difficulties in the assessment of peripheral and central nervous system lesions are stressed.


    1222/2523

    Tytuł oryginału: F2-isoprostanes biomarkers of lipid peroxidation: their utility in evaluation of oxidative stress induced by toxic agents.
    Autorzy: Piłacik Bożena, Wrońska-Nofer Teresa, Wąsowicz Wojciech
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.19-27, il., bibliogr. 74 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: Isoprostanes are prostaglandin-like compounds that are produced by free radical mediated peroxidation of polyunsaturated fatty acids. There is a direct evidence showing that F2-isoprostanes can be utilized as a marker of lipid peroxidation due to the mechanism of their foramtion (nonenzymatic exidation of arachidonic acid), chemical stability, sensitive and non-invasive methods of their estiamtion. An altered generation of F2-isoprostanes has been found in a variety of pathological syndromes associated with oxidative stress. Their quantification allows to elucidate the role of free radicals in oxidative injury. This paper reviews briefly the recent data on isoprostanes: biochemical mechanisms of their formation, methods of their measurement, and the possibilities of their utilization as a quantitative/qualitative marker of oxidative stress in vivo.


    1223/2523

    Tytuł oryginału: Theoretical assumptions and psychometric characteristics of the sense of personal control at work questionnaire.
    Autorzy: Dudek Bohdan, Merecz Dorota, Makowska Zofia
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.29-36, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Personal control is a very important determinant of stress experiennced at work. This variable is taken int account in different models of stress, and its role in the relationship between stress and stress effects has been studied in many research projects. But there is still lack of in-depth theoretical considerations on various definitions of control, which would allow to develop precise operationalization of this phenomenon. The following issues are discussed in this paper: 1) theoretical assumptions important for proper construction of the Sense of Personal Control at Work (SPCW); 2) the origins of SPCW Questionnaire; 3) the results of empirical study on psychometric charactieristics of the SPCW questionnaire. A group of 160 subjects participated in the study; the SPCW Questionnaire was administserd twice with a 2-week interval; at the first stage, it was used together with other instruments, such as Maslach Burnout Inventory, Stress at Work Questionnaire, Work Satisfaction Scale, general Health Questionnaire-28. Reliaility coefficients: cronbach a = 0.81; rtt = 0.69. Validity: correlation coeffcients between personal control and work satisfaction r = 0.44; stress at work r = -0.33; emotional exhaustion r = -0.28; personal accomplishment r = 0.25; depersonalisation r - -0.26; mental health r = -0.19. Explaratory factors analysis have not confirmed theoretical structure of the SPCW Questionnaire.


    1224/2523

    Tytuł oryginału: Toxicokinetics and metabolism of pseudocumene (1,2,4-trimethylbenzene) after inhalation exposure in rats.
    Autorzy: Świercz Radosław, Rydzyński Konrad, Wąsowicz Wojciech, Majcherek Wanda, Wesołowski Wiktor
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.37-42, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The objective of this study was to evaluate the toxicokinetics and metabolism of pseudocumene after inhalation exposure. Male Wistar rats were exposed to pseudocumene vapors at nominal concentrations of 25, 100 or 250 ppm in the dynamic inhalation chambers for 6 h. Blood samples were collected during (between 1st and 6th h) and after exposure (between 6th min and 6th h). Blood concentrations of pseudocumene were estiamted by gas chromatography using the headspace technique. During a six-hour exposure, the concentration of pseudocumene in blood increased rapidly within the first 2 h reaching then a plateau. The elimination of pseudocumene from blood followed an open two-compartment model. Urine samples were collected from the exposed animals, and metabolites were analyzed by gas chromatography with a flame ionization detector. Three metabolites were measured in the rat uring after hydrolysis: 3,4-dimethylbenzoic acid (3,4-DMBA), 2,4-dimethylbenzoid acid (2,4-DMBA) and 2,5-dimethylbenzoic acid (2,5-DMBA). A significant linear correlation was found between the level of exposure and the concentration of dimethylbenzoic acids. The enzyme kinetics of pseudocumene biotransformation was calculated by Lineweaver-Burk equation. Metabolic constants, Km (mg/l) and Vmax (mg/h/kg), the parameters for pseudocumene biotransformation by rats were estiamted (3,4-DMBA-Km = 28, Vmax = 96; 2,4-DMBA - Km = 7, Vmax = 25; 2,5-DMBA - Km = 7, Vmax = 23).


    1225/2523

    Tytuł oryginału: Risk for early ischemic event after acute myocardial infarction in working males.
    Autorzy: Froom Paul, Gofer Dafna, Boyko Valentina, Goldbourt Uri
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.43-48, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We attempt to predict ischemic events in the weeks following the hospital discharge after acute myocaridal infarction (AMI) in order to aid occupational physicians in taking return-to-work decisions. Included in the study were 1299 AMI patients from 14 coronary care units in Israel who had been employed before hospitalization and were seen after discharge 1,2,4,6, 9 and 12 months after the first AMI. Cardiovascular accidnts included death from cardiovascular disease, recurrent infarction or hospitalization due to congestive heart failure or unstable angina. The rate of a first recurrent cardiovascular accident decreased rapidly over the first few weeks. The risk in the third week was still 51 per 1000 person-months, 13.4 (95 p.c. Cl: 9.2 - 19.5) times higher than that after 10 weeks when the incidence reached a low steady state. The major predictors in a logistic regression model for an event were: older age, past history of a cerebrovascular event, and congestive heart failure during the course of hospitalization, but the area under the receiver-operator curve was only 64.4 p.c. We conclude that after acute myocardial infarction, the major risk for a recurrent event is a lapse of tiem from discharge but not other clinical variables. This should be taken into account when considering a proper timing of return-to-work after an acute myocardial infarction.


    1226/2523

    Tytuł oryginału: Work-related unjuries among firefighters: sites and circumstances of their occurrence.
    Autorzy: Szubert Zuzanna, Sobala Wojciech
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.49-55, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the present study was to determine the injury ratio, causes and duration of temporal work disability from on-duty injuries among firefighters, taking into acount the site and circumstances of their occurrence. The study was performed on a representative sample of 1503 firefighters from 29 fire stations who were employed between 1994 and 1997. Subject to investigation were data on the numer of days and cases of work disability due to on-duty injury, personal data (age, work duration) and data on the circumstances of injury during emergency operations, taking part in compulsory physical training, performing maintenance and repair works, on duty at the fire station, and when commuting to or from work. The analysis of work-related causes and cirucmstance of injuries among fireflighters revealed that the majority of injuries (40 p.c.) occurred during compulsory physical training, being responsible for 41 p.c. of post-injury absence at work. The workers employed for less than one year were at highest risk of injury. Injuries during emergency operations made 25 p.c. of all injuries and accounted for 24 p.c. of post-injury absence. The analysis of data showed that the frequency of injuries was not significantly aged-dependent, however, the duration of work disability was found to increase by 20 p.c. with increasing age og workers. The results indicated the need for undertaking preventive intervetions to minimize occupational hazards to those involved in firefighting.


    1227/2523

    Tytuł oryginału: Evaluation of airborne dust and endotoxin in corn storage and processing facilities in Colorado.
    Autorzy: Buchan Roy M., Rijal Pabitra, Sandfort Delvin, Keefe Tom
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.57-64, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The main objectives of this research were to determine what aerosols were present by taking total dust (TD) samples and thoracic particulate mass samples (TPM) on farms and in grain elevators. Cascade impactors were used to characterize size distributions of dust and endotoxing at each site. Total dust concentrations on farms had a genometric mean 3.4 mg/m3 adn 3.3 mg/m3 in elevators. The geometric mean (GM) concentrations for the TPM were 2.4 mg/m3 on farms and 1.0 mg/m3 in elevators. Endotoxin concentrations as geometric means were alarming at 3175 EU/m3 total dust and 983 EU/m3 by TPM on farms. In elevators, the GM concentrations for endotoxins were 2534 EU/m3 total dust, and 526 EU/m3 by TPM. The mass median aerodynamic diameter (MMAD) for endotoxins on farms was 8.0 ćm and 6.5 ćm in elevators. The paired t-test was applied to the log ratios of endotoxin concentrations (EU/m3) and dust concentrations (mg/m3), for paired samples of the TD and TPM. A higher content of endotoxings was associated with TPM for farms but not elevators. It was concluded that although the TPM fraction (dust) may represent a small part of the total mass, the aerosol size is optimum for deposition in the lung's tubular airways, and might cause airway inflamation due to the endotoxins. The TPM fraction of corn dust represents the best measure of exposure with regard to the potential development of long-term airways inflammation, and the potential of chronic obstructive pulmonary disease among chronically exposed workers. All endotoxin concentrations were well above recommendd exposure levels of several researchers familiar with endotoxin health effects.


    1228/2523

    Tytuł oryginału: Asbestos in water sources of the Bazhenovskoye chrysotile asbestos deposit.
    Autorzy: Kashansky Sergey V., Slyshkina Tatiana V.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.65-68, tab., bibliogr. 13 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The paper provides measurements of asbestos fiber levels in water sources from the area of the Bazhenovskoye chrysotile asbestos deposit. All study water samples contained asestos fibers at concentrations one to three orders below the values standardized in the USA (7ú10**6 fibers/liter). All the identified fibers belonged to chrysotile asbestos and no amphibole asbestos, such as tremolite asbestos, has been identified. The anthropogenic load of asbestos fibers in Asbest City's environment is increasing in the volume of 5.770ú10**f14 fibers/liter or 10.2 kg of chrysotile asbestos. The authors consider it advisable to continue studies to measure asbestos levels in the water sources in the areas located in the vicinity of oter Russian asbestos deposits.


    1229/2523

    Tytuł oryginału: Alfred Grotjahn ber Žrzte als Patienten.
    Tytuł polski: Alfred Grotjahn o lekarzach jako pacjentach.
    Autorzy: Goerke Heinz
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.141-149, bibliogr. [7] poz., streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna

    Temat osobowy:
  • Grotjahn
  • Alfred 1869-1931

    Streszczenie polskie: Twórca higieny społecznej jako dyscypliny akademickiej w Niemczech, Alfred Grotjahn (1869-1931), opublikował w roku 1929 zbiór historii choroby, jakie o swoich chorobach sporządzili sami lekarze. Raporty te, Grotjahn zaczerpnął z trzech różnych źródeł: 1) z literatury autobiograficznej, 2) z publikacji kazuistycznych i 3) z badań własnych przeprowadzonych w formie ankiety. Do przeprowadzenia tych studiów skłoniło go przekonanie, iż z reguły brak jest wystarczającego psychologicznego zrozumienia osób wykonujących zawód lekarski dla subiektywnych przeżyć chorych w stosunku do ich choroby, ale także w relacjach z lekarzami i podejmowanymi przez nich działaniami diagnostycznymi i terapeutycznymi. Za celowe uważał uzyskanie wiedzy na temat odczuć własnych i obserwacji samych lekarzy jako chorych, dlatego iż raczej to w ich przypadku, a nie w przypadku osób nie posiadających fachowej wiedzy medycznej należało spodziewać się zarówno trzeźwego jak i obejmującego szczegóły opisu. Jego lekarskie samoobserwacje, jakie udało się pozyskać z literatury autobiograficznej i kazuistycznej, nie przyniosły jednak zbyt wielu informacji. Grotjahn przypuszczał, iż wynikało to ze swego rodzaju nieśmiałości w udzielaniu dokładniejszych informacji dotyczących bardziej intymnych spraw własnej osoby, ale chyba również i z tego, iż niechętnie przechowywano we wspomnieniach choroby jako nieprzyjemne zaburzenia w wykonywaniu zawodu. Inaczej jednak przedstawiały się wyniki rozesłanych przez niego ankiet. Gwarantowały one anonimowość; przedłożono raporty oceniane przez Grotjahna jako szczególnie cenne...


    1230/2523

    Tytuł oryginału: Konflikte zwischen Patienten und Žrzten in wrttembergischen Lungenheilanstalten Anfang des 20. Jahrhunderts.
    Tytuł polski: Konflikty pomiędzy pacjentami a lekarzami w wirtemberskich zakładach leczenia chorób płuc na początku 20-tego stulecia.
    Autorzy: H„hner-Rombach Sylvelyn
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.151-161, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XX wieku
  • ludzie
  • płeć męska

    Streszczenie polskie: Zakłady leczenia chorób płuc borykały się od początku 20-tego stulecia z różnorodnymi problemami ze swymi męskimi pacjentami, dla których trzymiesięczny pobyt ze ściśle określonymi normami zachowania był przyczyną wielu niesnasek. U niektórych pacjentów doprowadziły one do przedwczesnego przerwania postępowania leczniczego, do opuszczenia zakładów bez zezwolenia i do innych wykroczeń w stosunku do reguł zakładów. Próbując utrzymać dyscyplinę medyczną kierownictwo zakładów sięgało po środek polegający na zwolnieniu. Przyczyny takiego zachowania i reakcji na nie zostaną przedstawione na przykładzie zakładów leczenia chorób płuc w Wirtembergii na początku 20-tego stulecia. W centrum zainteresowania pozostaną pacjenci posiadający ubezpieczenie społeczne, których pobyt w zakładach leczniczych opłacany był przez Krajowy Zakład Ubezpieczeń w Wirtembergii. Pod koniec 19-tego i na początku 20-tego stulecia punktem spornym między pacjentami zakładów leczniczych, a lekarzami było w kwestiach terapeutycznych i diagnostycznych stosowanie tuberkuliny. Zaledwie kilka lat po tak zwanej "euforii tuberkulinowej", pacjenci odmawiali jej przyjmowania lub mieli do niej nieufny stosunek. Pacjenci wywodzący się w komplecie z warstwy robotniczej, okazali się być w sytuacjach konfliktowych z lekarzami jednostkami świadomymi wiedzącymi przynajmniej dokładnie, czego nie chcą.


    1231/2523

    Tytuł oryginału: Literaten des 19. Jahrhunderts und ihre Sicht auf Zahnheilkundliches und den Zahnarzt.
    Tytuł polski: Literatura 19-stego stulecia i jej spojrzenie na leczenie stomatologiczne i lekarzy stomatologów.
    Autorzy: Heidel Caris-Petra, Peikert Sylvia
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.163-178, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia XIX wieku

    Streszczenie polskie: Zdrowie i choroba, czynności lekarskie i wreszcie lekarz jako wiodące wątki w literaturze pięknej stanowiły - nie tylko w najnowszych czasach - przedmiot badań zarówno historyczno-literackich i historyczno-społecznych jak i dotyczących historii medycyny. Mimo to jednak poważni autorzy dochodzą do przekonania, iż na polu literatury na możliwe zbadanie w kontekście historyczno-medycznym czeka jeszcze bardzo obszerny materiał źródłowy. O wiele bardziej krytycznie należy w związku z tym potraktować sytuację dotyczącą opracowania tematu leczenia stomatologicznego w literaturze pięknej. Pominąwszy fakt, iż znanych jest stosunkowo niewiele dzieł literackich podejmujących tematykę leczenia stomatologicznego lub lekarzy stomatologów lub też fakt, iż prawie nie ma dostępnych badań historycznych w tym zakresie, to dotychczas w szczególności nie poddano systematycznej analizie wpływu osobistych doświadczeń literatów ze stomatologią i lekarzem stomatologiem na ich dzieła. Po analizie dzienników, notatek o charakterze osobistym, listów i wspomnień przede wszystkim literatów 19-tego i początku 20-tego stulecia takich jak Heinrich Heine, Friedrich Hebbel i Thomas Mann można wyciągnąć w tej kwestii jednak dość jednoznaczne wnioski. Przeżyte w bardzo różnych uwarunkowaniach i okolicznościach spotkania wymienionych wyżej literatów z lekarzami stomatologami i częściowo długotrwałe i bolesne doświadczenia ze schorzeniami zębów i leczeniem stomatologicznym, znalazły w końcu także swój wyraz w ich dziele literackim. Dowodem tego są zarówno stosunkowo dokładne opisy praktyk stomatologicznych jak i stosunkowo różne prezentacje osoby i roli lekarza stomatologa przedstawiane w różnym czasie przez jednego i tego samego autora.


    1232/2523

    Tytuł oryginału: Philipp Melanchthon (1497-1560) und die akademische Medizin in Wittenberg.
    Tytuł polski: Philipp Melanchthon (1497-1560) i medycyna akademicka w Wittenberdze.
    Autorzy: Helm Jrgen
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.179-196, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia XVI wieku

    Temat osobowy:
  • Melanchthon
  • Philipp 1497-1560

    Streszczenie polskie: Stosunek Philippa Melanchthona do medycyny akademickiej jego epoki wielokrotnie stanowił w minionych latach przedmiot studiów medyczno-historycznych. Wykład podsumowuje najistotniejsze wyniki tych prac i pokazuje, czy i w jaki sposób propgram odnowy medycyny Melanchthona wywarł wpływ na zajęcia medyczne na Leucorea. Ponadto w oparciu o porównanie Uniwersytetu w Wittenberdze i katolickiego Uniwersytetu w Ingolstadt, poddaje analizie przypuszczenie wyrażane w nowszych pracach, niż w medycynie akademickiej 16-tego stulecia (również wskutek wpływu Melanchthona) różnice uwarunkowane wyznaniem. Prezentacja ta w formie uroczystego wykładu wypełnia ramy przypadającego na rok 2002 jubileuszu 500-lecia utworzenia Uniwersytetu w Wittenberdze.


    1233/2523

    Tytuł oryginału: Selektion und Attraktion. Patienten im klinischen Versuch im frhen 19. Jahrhundert.
    Tytuł polski: Dobór i atrakcja. Pacjenci w eksperymentach klinicznych w początkach 19-tego stulecia.
    Autorzy: Hess Volker, Thoms Ulrike
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.197-207, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XIX wieku

    Streszczenie polskie: Swobodny dostęp do pacjentów uważany jest w współczesnym piśmiennictwie historii społecznej za istotny warunek powstania nowoczesnej medycyny szpitalnej. Dotyczy to w szczególności rozwoju eksperymentu klinicznego stanowiącego dzisiaj metodyczny standard nauk klinicznych. Podczas gdy wielokrotnie w ostatnich latach podejmowano kwestię dowolności i uzyskania przyzwolenia chorego w okresie po roku 1850, to wyraźnie brak jest jeszcze studiów empirycznych dotyczących doboru i dostępności pacjentów w początkach 19-tego stulecia. Wgląd w praktykę takich eksperymentów dają źródła archiwalne o eksperymentach klinicznych przeprowadzonych w Charit‚ w Berlinie w okresie od 1800 roku do roku 1850. Zawierają one również petycje osób proszących pilnie o dopuszczenie do eksperymentów. W tym kontekście wykład ten próbuje rzucić światło na wzajemne relacje wyznaczone z jednej strony kryteriami doboru medycznego i z drugiej pragnieniem uczestnictwa w eksperymentach, a być może uzyskania jakiś korzyści dla siebie samego. W oparciu o jakie kryteria medyczne dokonywano wyboru pacjentów? Czy w grupie wybranych osobników badanych skonstatować można jakieś cechy wspólne i jakie one miały charakter? Co skłaniało ludzi do błagania o przyjęcie do szeregu uczestników eksperymentu?


    1234/2523

    Tytuł oryginału: Leprakranke im Spiegel sp„tmittelalterlich-frhneuzeitlicher Schauprotokolle und Selbstzeugnisse.
    Tytuł polski: Trędowaci w świetle późnośredniowiecznych i wczesnonowożytnych dokumentów i w świadectwach własnych.
    Autorzy: Jankrift Kay Peter
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.209-217, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia średniowiecza

    Streszczenie polskie: Żadna inna choroba nie poddawała ludzi z epoki późnego średniowiecza i wczesnych czasów nowożytnych takiemu zakresowi decydowania o ich losie jak "trąd" - choroba tak określana przez współczesnych. Do okresu późnego średniowiecza na terenie Rzeszy Niemieckiej wytworzyły się różne centra - oględzin, których pozytywne orzeczenie powodowało radykalne konsekwencje dla dalszego losu osoby podejrzanej o trąd: utratę dotychczasowego otoczenia i przystąpienie do wspólnoty "żyjących" zmarłych w jakimś leprozorium. Informacje o traktowaniu osób podejrzanych o trąd i chorych na trąd ukazane są w świetle dokumentów i raportów oględzinowych poszczególnych zakładów dla trędowatych. Niuanse spowodowane są rodzajem badań wykonywanych z jednej strony przez samych trędowatych mistrzów, a z drugiej strony od 15-tego stulecia na niemieckim obszarze językowym w coraz znaczniejszym stopniu przez lekarzy i chirurgów. Szeroki wgląd w środowisko społeczne badanych, tło podejrzenia o występowanie trądu i orzeczenia umożliwiają zachowane w znacznej ilości dokumenty Wydziału Medycznego Uniwersytetu w Kolonii, uzupełnione w ramach niniejszego wystąpienia kolejnymi świadectwami, przykładowo z Lttich. Światło na samoodbiór trędowatych i podejrzanych o trąd rzucają podania o przyjęcie, jak na przykład Josta Heerde, przyjętego do lepozorium w Mnstwer na początku 17-go stulecia, a także wypowiedzi mieszkańców zakładu dla trędowatych przy okazji wizytacji lekarskich, na przykład z Paderborn w Westfalii.


    1235/2523

    Tytuł oryginału: Arzt und Patient im Lichte preussischer Medizinal-Edikte fr Schlesien.
    Tytuł polski: Lekarz a pacjent w świetle pruskich edyktów medycznych dla Śląska.
    Autorzy: Jonecko Antoni
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.251-279, il., bibliogr. 43 poz., streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Hasła klasyfikacyjne GBL:
  • prawo

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XVIII wieku
  • historia XIX wieku

    Temat korporatywny:
  • Śląsk

    Streszczenie polskie: Po zajęciu Śląska przez Prusy w XVIII wieku, ustanowiono zrazu "Komisariat Wojenny". Następnie utworzono "Izby dla Spraw Wojny i Domen". Przy izbach istniało "Kolegium Medyczne", ktore zajmowało sie polityką zdrowotną, szkoleniem i rozstrzygało spory pomiędzy lekarzami, chirurgami i aptekarzami. Należy odróżnić: 1) ustrój Śląska staro-pruski, który trwał od zajęcia Śląska w 1742 roku, aż do lat 1806-1812, - oraz 2) ustrój nowo-pruski Śląska, wieku XIX. Przedstawiona praca zajmuje się pruskimi sprawami medycznymi głównie pierwszego okresu. Władze pruskie Śląska wydały drukiem bardzo wiele edyktów, regulaminów i patentów o treści medycznej i socjalnej. Drukowano je w różnych oficynach i różnych miastach. Rozporządzenia te były wydawane w języku niemieckim i również w języku polskim. Dokumenty te pozwalają na określenie stosunku lekarza do pacjenta i stosunku absolutystycznego państwa do ludności. Pruska polityka zdrowotna zajmowała się głównie epidemiami, wakcynacją, modnym wówczas zagadnieniem śmierci pozornej i reanimacji, problemami osób kalekich, ubogich, tudzież weteranami, sierotami i wdowami wojennymi, zbiegami oraz tzw. "Domami Poprawy". Największym zainteresowaniem urzędowym cieszyły się rzemieślniczo uprawiane zawody chirurgów, położnych i aptekarzy. Władze pruskie dobrze rozpoznały dużą przydatność i wydolność tych profesji i przyczyniły się do doskonalenia i awansu tych zawodów. Edykty dla Śląska, dla częściowo autonomicznego "Księstwa Śląskiego i Hrabstwa Kłodzkiego" były sygnowane przez króla Fryderyka II, Fryderyka Wilhelma I, Fryderyka Wilhelma II lub Fryderyka Wilhelma III...


    1236/2523

    Tytuł oryginału: Der Chemiker Ragnar Berg (1873-1956) und sein Beitrag zur Ern„hrungsforschung.
    Tytuł polski: Chemik Ragnar Berg (1873-1956) i jego wkład do badań nad odżywianiem.
    Autorzy: Lienert Marina, Rummel Christian
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.311-313, bibliogr. 1 poz. streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Berg
  • Ragnar 1873-1956

    Streszczenie polskie: Doniesienie zajmuje się zwięzłym przedstawianiem osiągnięć badawczych szwedzkiego chemika Ragnara Berga. Jest on znany w związku z jego teorią o odżywianiu nadmiernie zasadowym i odżywianiu nadmiernie kwasorodnym. W zakresie praktyki żywieniowej Berg stwierdził, iż gotowanie jarzyn doprowadza do nadmuiernych strat cennych składników mineralnych. Dlatego zalecał i wprowadził technikę parowania, zamiast niekorzystnego gotowania. Po ukazaniu się monografii Kazimierza Funka, o witaminach w roku 1914, Ranger Berg opublikował drugą z kolei monografię na temat witamin. Berg upamiętnił się w historii techniki żywieniowej poprzez swoje niezwykle ważne i pracochłonne badania nad pierwiastkami śladowymi.


    1237/2523

    Tytuł oryginału: Žltere Patienten in der Medizinischen Klinik der Universit„t Tbingen 1880-1914.
    Tytuł polski: Starsi pacjenci hospitalizowani w Klinice Medycznej Uniwersytetu w Tybindze w latach 1880-1914.
    Autorzy: Moses Simone
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.315-326, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XIX wieku
  • historia XX wieku
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • ludzie

    Streszczenie polskie: W wykładzie zostaną zaprezentowane wyniki analizy ilościowej pacjentów powyżej 55 roku życia w podanym przedziale czasowym. Wykorzystane źródła wyjaśniają kwestie związane z łączną liczbą pacjentów rocznie, ich płcią, wiekiem, zawodem, miejscem zamieszkania i wyznaniem, terminem przyjęcia do szpitala. Wskazują też na to, czy pacjent zmarł w szpitalu. Stwierdzić można, kto płacił za pobyt w klinice i czy ten sam pacjent znalazł się w szpitalu wielokrotnie. Częściowo znaleść też można informacje o zdiagnozowanych chorobach. Istotnym czynnikiem zwiększenia liczby pacjentów starszych w szpitalach było wprowadzenie w latach 1880/90 ustawowego ubezpieczenia zdrowotnego, wypadkowego i na wypadek inwalidztwa. W badanym okresie udział bezpłatnie przyjmowanych do szpitala biednych chorych malał na korzyść pacjentów dysponujących teraz ubezpieczeniem społecznym. Klinika uniwersytecka cieszyła się również dobrą opinią wśród bardziej zamożnych pacjentów, jako że ich udział wśród chorych kliniki medycznej był zawsze stosunkowo wysoki i wzrósł nawet po przełomie wieków. Chociaż starsi pacjenci stawiali wysokie wymagania instytucji medycznej, to spadające wskaźniki umieralności podczas badanego okresu wskazują na coraz lepsze możliwości leczenia.


    1238/2523

    Tytuł oryginału: Therapeutische Effizienz und subjektive Krankheitserfahrung im 18. Jahrhundert.
    Tytuł polski: Terapeutyczna efektywność a subiektywne doświadczenie chorobowe w 18-tym stuleciu.
    Autorzy: Stolberg Michael
    Źródło: Arch. Hist. Filoz. Med. 2002: 65 (2/3) : VIII Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny "Chory między samostanowieniem a paternalizmem" s.375-381, streszcz. - 8 Wspólna Konferencja Polsko-Niemieckiego Towarzystwa Historii Medycyny pt. Chory między samostanowieniem a paternalizmem Wittenberga 06-08.09. 2001
    Sygnatura GBL: 301,366

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XVIII wieku

    Streszczenie polskie: Lekarze i historycy medycyny ze zdumieniem coraz częściej konstatują dominującą rolę i dużą siłę bezwladności w odniesieniu do upustu krwi, środków przeczyszczających oraz innych środków i metod stosowanych w medycynie minionych epok. Są to bowiem rozwiązania terapeutyczne, które wedle dzisiejszego stanu wiedzy były nieskuteczne lub nawet szkodliwe. W moim wykładzie chciałbym pominąć kwestię "rzeczywistej" skuteczności z dzisiejszej perspektywy. Chciałbym skoncentrować się głównie na zbadaniu, jak laicy medyczni 18-tego stulecia oceniali i odbierali skuteczność leczenia przez lekarzy. Za źródło posłużą mi setki listów pacjentów, a mówiąc dokładniej francuskich i niemieckich konsultacji listownych przeprowadzonych przez laików. Badam je obecnie w ramach zakrojonego na szerszą skalę projektu badawczego. Pacjenci lub członkowie ich rodzin lub też ich znajomi obszernie informują o sukcesach przepisów lekarskich, zarówno z perspektywy dotychczasowej historii jaki i w odniesieniu do wcześniejszych zaleceń terapeutycznych lekarza, który przeprowadził listowną konsultację. Nie pozostawjają przy tym jakichkolwiek wątpliwości, że wspomniane środki i sposoby leczenia uważali za skuteczne. Liczni pacjenci prezentują bardzo konkretną poprawę ich stanu fizycznego po zastosowaniu upustu krwi, środków przeczyszczających lub tylko kąpieli. Ze swej strony domagali się zastosowania odpowiedniego leczenia lub ośwadczali o rezygnacji z niego z uwagi na jego zły przebieg. Listy dokumentują jednak również liczne przypadki niepowodzeń terapeutycznych i jednocześnie wskazują na różne wyjaśnienia, jakie laicy medycznmi znajdowali dla wytłumaczenia tych niepowodzeń, nie poddając w wątpliwość ważności i skuteczności terapii zwolenników teorii humoralnej.


    1239/2523

    Tytuł oryginału: The results of postoperative irradiation for locally advanced carcinoma of the larynx.
    Tytuł polski: Ocena wyników pooperacyjnego napromieniania chorych na miejscowo zaawansowanego raka krtani.
    Autorzy: Wieczorek Andrzej, Fijuth Jacek, Michalski Wojciech
    Źródło: Nowotwory 2002: 52 (4) s.287-294, il., tab., bibliogr. 38 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wstęp. Celem pracy był retrospektywna anlaiza wyników pooperacyjnej radioterapii u chorych na zaawansowanego raka krtani oraz ocena wpływu czynników prognostycznych klinicznych i terapeutycznych na rokowanie. Materiał. Materiał kliniczny stanowiła grupa 165 chorych na miejscowo zaawansowanego raka krtani, leczonych w latach 1985-1996, u których przeprowadzono uzupełniające pooperacyjne napromienianie. Wszyscy chorzy mieli wcześniej wykonany zabieg operacyjny, polegający na całkowitym usunięciu krtani, połączonym w 91 przypadkach z jednostronną lub obustronną operacją węzłów chłonnych szyi. Czas od operacji do rozpczęcia naporomieniania po operacji wyniósł od 15 do 162 dni (średnia 53). Dawka całkowita wahała się od 50 Gy do 70 Gy przy dawce frakcyjnej 2 Gy. Analizie poddano czas przeżycia oraz czas do miejscowego nawrotu. Prawdopodobieństwo przeżycia obliczano metodą Kaplana-Meiera. Zbadano wpływ: płci, wieku, stopnia, sprawności, stopni zaawansowania T i N, lokalizacji nowotworu, poziomu hemoglobiny, stopnia zróżnicowania histologicznego, zajęcia usuniętych węzłów chłonnych, przejścia nacieku poza torebkę węzła, stopnia doszczętności zabiegu operacyjnego, obecności niekorzystnych cech rokowniczych, związanych z rozrostem guza pierwotnego (zejście pod głośnię, przejście nacieku poza granice anatomiczne krtani, naciekanie chrząstek lub kombinacja powyższych cech) oraz czas od operacji do rozpoczęcia radioterapii na czas przeżycia oraz czas do wystąpienia miejscowego nawrotu, posługując się modelem proporcjonalneg ryzyka D. R. Cox'a...


    1240/2523

    Tytuł oryginału: Anastomosis site - a risk factor for anastomotic leakage after elective anterior resection of rectal cancer.
    Tytuł polski: Wysokość zespolenia jako czynnik ryzyka nieszczelności u chorych po elektywnej resekcji przedniej z powodu raka odbytnicy.
    Autorzy: Rutkowski Andrzej, Nowacki Marek P., Olędzki Janusz, Bujko Krzysztof
    Źródło: Nowotwory 2002: 52 (4) s.295-299, tab., bibliogr. 24 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było ustalenie zależności pomiędzy wysokością zespolenia okrężniczo-odbytniczego, a ryzykiem nieszczelności i reoperacji. Badano również zależność pomiędzy odległością guza od brzegu odbytu, a szansą na wykonanie operacji oszczędzającej zwieracze. Metoda. Oceniono retrospektywnie 301 chorych, u których wykonano elektywną resekcję przednią z powodu raka odbytnicy. Z badania wyłączono pacjentów, u których występowały naglące wskazania do operacji oraz będących w złym stanie ogólnym, z niedokrwistością lub cukrzycą insulinozależną, o ponad 10-letnim przebiegu. Oceniono ryzyko występowania objawowej nieszczelności. Nieszczelność zespolenia podejrzewano w przypadku objawów rozlanego zapalenia otrzewnej, ropnia w miednicy, obecności gazu lub ropy w drenie. Podejrzenie to weryfikowano badaniem per rectum, ednoskopowo, badaniami obrazowymi oraz oceniano śródoperacyjnie, jeżeli stan chorego wymagał reoperacji. Analizy statystycznej dokonano przy pomocy testu chi-kwadrat przy założonym progu znamienności p 0,05. Wyniki. Wczesne powikłania pooperacyjne (do 30 dni od zabiegu) wystąpiły u 94 chorych (31,2 proc.). Zmarło 2 pacjentów (0,7 proc.). Odsetek nieszczelności zespoleń wyniósł 13,6 proc. Największe ryzyko nieszczelności stwierdzono wówczas gdy dolna granica guza znajdowała się w odległości od 5 cm (26,5 proc.). Przy takim umiejscowieni, odsetek operacji oszczędzających zwieracze był mały (33,1 proc.). Gdy dolna granica guza znajdowałą się w środkowej części odbytnicy, ale poniżej załąmka otrzewnej (powyżej 5 cm do 7-8 cm od brzegu odbytu), ryzyko nieszczelności zespolenia wynosiło 17,3 proc...


    1241/2523

    Tytuł oryginału: Results of treatment with concurrent radiotherapy and cisplatin-based chemotherapy for cancer of the uterine cervix - a preliminary assessment.
    Tytuł polski: Wstępna ocena wyników leczenia raka szyjki macicy napromienianiem skojarzonym z chemioterapią opartą na cisplatynie.
    Autorzy: Rusiecka Małgorzata, Ziemba Beata, Dryl Jacek, Bojarowska Katarzyna, Słocka Beata
    Źródło: Nowotwory 2002: 52 (4) s.301-304, tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: Cel. Badanie podjęto w celu wykazania różnicy w wynikach leczenia radiochemioterapią i radioterapią, oraz wskazania metody skuteczniejszej w leczeniu raka szyjki macicy. Materiał i metoda. Badaniem objęto 53 chore na płaskonabłonkowego raka szyjki macicy, poddane radiochemioterapii w okresie od maja 2000 r. do czerwca 2001 r. z powodu nowotworu zaawansowanego miejscowo: stadia kliniczne od IB-2 do IVA - grupa C. Grupę kontrolną stanowiło 50 kobiet z rozpoznanym rakiem szyjki macicy, w stadiach zaawansowania klinicznego od IB-1 do IVA, leczonych wyłącznie radioterapią w 1997 roku - grupa R. Obie grupy były porównywalne pod względem wieku, warunków napromieniania, rodzaju brachyterapii. W grupie C znalazło się więcej chorych z zaawansowanym nowotworem (bulky, oraz przewaga liczbena wyższych stadiów klinicznych). W grupie tej zastosowano wlewy cisplatyny 1 raz w tygodniu w dawce 40 mg/mý, lecz nie więcej niż 70 mg na 1 wlew. Z powodu masywnego krwawienia z dróg rodnych 6 chorych napromieniono metodą hiperfracji: 2 x 1,2 Gy z przerwą 8 h, aby nie stosować hipofrakcjonacji hemostatycznej. Wyniki. U wszystkich chorych grupy C zaobserwowano pozytywny efekt terapii, w tym ponad 50 proc. całkowitych remisji. U ponad 70 proc. kobiet stosowano sterydy z powodu leukopenii, a 4 chore nie otrzymały pełnej chemioterapii - 6 kursów cisplatyny, z powodu trombocytopenii, które wydaje się być największym problemem leczenia skojarzonego. Ilość odczynów poprowmiennych wzrosła, lecz nie wydłużyła się w czasie, ani nie osiągnęła większego natężenia. Podsumowanie. Wczesne wyniki skojarzonego leczenia radiochemioterapią płąskonabłonkowego raka szyjki macicy są bardzo obiecujące i rekomendują powyższy schemat jako standard terapeutyczny w tym schorzeniu.


    1242/2523

    Tytuł oryginału: Magnetic resonance imaging (MRI) in cervical carcinoma - assessment of diagnostic value of tumour volume.
    Tytuł polski: Badanie metodą rezonansu magnetycznego raka szyjki macicy - ocena wartości diagnostycznej objętości guza.
    Autorzy: Tacikowska Małgorzata, Grzesiakowska Urszula, Sobiczewski Piotr, Tacikowski Tadeusz
    Źródło: Nowotwory 2002: 52 (4) s.305-308, tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Badanie metodą rezonansu magnetycznego (MR) odgrywa kluczową rolę w diagnostyce raka szyjki macicy. Jedną z ważnych części badania MR jest pomiar objętości guza. Cel. 1) ocena zgodności pomiaru objętości w badaniu MR z pooperacyjnym badaniem histopatologicznym; 2) ocena korelacji objętości i największego wymiaru raka szyjki macicy (ocenianych w badaniu MR) z następującymi parametrami: a) stopniem zaawansowania według klasyfikacji FIGO; b) naciekaniem przymacicza; c) przerzutami do węzłów chłonnych. Materiał i metoda. Materiał stanowią badania MR miednicy, wykonane aparatem firmy Elscint 2T, u 21 chorych na raka szyjki macicy. Wiek chorych od 37 do 73 lat. U 15 pacjentek po badaniu MR przeprowadzono operację usunięcia macicy, w pozostałych przypadkach rozpoznanie postawiono na podstawie biopsji. U 10 chorych operowanych dokonano oceny porównawczej objętości guza, ocenianej w badaniach MR i histopatologicznym. U 16 chorych analizowano korelację objętości guza ze stopniem zaawansowania, naciekanim przymacicza i powiększeniem węzłów chłonnych. Wnioski. 1) stwierdzono wysoką zgodnośc badania MR i histopatologicznego (po operacji) w pomiarze objętości guza, p = 0.764; 2) badanie MR z pomiarem objętości guza u chorych z rakiem szyjki macicy odznacza się 100 proc. czułością i specyficznością w rozgraniczeniu stopnia I od pozostałych; 3) ocena objętośći guza lepiej koreluje ze stopniem zaawansowania I i II wg FIGO niż ocena największego wymiaru zmiany; 4) stwierdzono korelację pomiędzy objętością guza i naciekaniem przymacicza; 4) nie stwierdzono korelacji objętości guza z przerzutami do węzłów chłonnych.


    1243/2523

    Tytuł oryginału: Successful use of activated recombinant factor FVIIa in the management of intra abdominal haemorrhage after cytoreductive surgery for advanced carcinoma of the ovary - a case report.
    Tytuł polski: Zastosowanie rekombinowanego czynnika krzepnięcia FVIIa w leczeniu ciężkiego krwotoku dootrzewnowego u chorej po rozległej operacji cytoredukcyjnej z powodu zaawansowanego raka jajnika - opis przypadku.
    Autorzy: Panek Grzegorz, Derlatka Paweł, Bidziński Mariusz, Stachurska Elżbieta, Krynicki Ryszard
    Źródło: Nowotwory 2002: 52 (4) s.309-311, tab., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Chirurgia cytoredukcyjna stanowi podstawę leczenia zaawansowanego raka jajnika. Towarzysząca tego typu operacjom utrata krwi oraz rozległe uszkodzenia tkanek mogą wyzwolić patologiczne procesy wykrzepiania i fibrynolizy, które w niektórych sytuacjach mogą stanowić bezpośrednie zagrożenie życia chorej. Przedstawiono szczegółowy opis przypadku skutecznego zastosowania rekombinowanego czynnika VIIa u chorej z ciężkim krwawieniem dootrzewnowym, po operacji cytoredukcyjnej, wyknywanej z powodu zaawansowanego raka jajnika. U chorej bez pierwotnych zaburzeń układu krzepnięcia krwi zastosowano dwukrotnie preparat NovoSeven w dawce 20 ćg/kg, uzyskując zatrzymanie krwawienia zagrażającego życiu. Korzystny efekt działania tego preparatu wskazuje na możliwość rozważenia jego użycia w przypadku ciężkich krwawień, niemożliwych do opanowania klasycznymi metodami.


    1244/2523

    Tytuł oryginału: Chondrosarcoma of the larynx: a case report and review of the literature.
    Tytuł polski: Chrzęstniakomięsak krtani; opis przypadku i przegląd literatury.
    Autorzy: Jackiewicz Piotr, Kawecki Andrzej, Nasierowska-Guttmejer Anna, Krajewski Romuald
    Źródło: Nowotwory 2002: 52 (4) s.312-315, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie polskie: Chrzęstniakomięsak (chondrosarcoma) jest rzadko występującym nowotworem krtani. Do tej pory w literaturze opiasno około 250 przypadków chrzęstniakomięsaka w tej lokalizacji. W niniejszej pracy przedstawiono przypadek 46-letniego mężczyzny, u którego w oparciu o badanie kliniczne i histiopatologiczne rozpoznano wysokodojrzałego chrzęstniakomięsaka krtani. Przeprowadzono radykalne leczenie operacyjne, polegające na laryngektomii. Badanie mikroskopowe materiału operacyjnego potwierdziło rozpoznanie chrzęstniakomięsaka o budowie mieszanej, złożonej z chrzęstniaka i chrzęstniakomięsaka, rozwijającego się w chrząstce pierścieniowatej. Ocena marginesów chirurgicznych wykazała całkowite wycięcie guza. W oparciu o przegląd literatury uzasadniono konieczność wykonania radykalnej laryngektomii w przypadku zaawansowanego chrzęstniakomięsaka krtani. Omówiono także problem związany z diagnozą guza oraz próbami wykonywania operacji oszczędzających. Takie czynniki jak: rzadkie występowanie choroby, powolny i skryty wzrost guza oraz obraz histopatologiczny przypominający chrzęstniaka utrudniają postawienie właściwego rozpoznania. Operacje oszczędzające, polegające na częściowej laryngektomii, powinny być zawsze brane pod uwagę. Nie ma jednak jeszcze wypracowanych kryteriów, które pozwoliłyby na zastosowanie leczenia, gwarantującego najlepsze rezultaty funkcjonalne i onkologiczne. Kryteria te powinny opierać się na stopniu zaawansowania klinicznego i stopniu dojrzałości histopatologciznej. W celu opracowania optymalnego leczenia konieczne są dalsze badania kliniczne.


    1245/2523

    Tytuł oryginału: Long-chain PUFA supplementation improves PUFA profile in infants with cholestasis.
    Autorzy: Socha Piotr, Koletzko Berthold, Jankowska Irena, Pawłowska Joanna, Demmelmair Hans, Stolarczyk Anna, Świątkowska Elżbieta, Socha Jerzy
    Źródło: Lipids 2002: 37 (10) s.953-957, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 305,815

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: Long-chaim PUFA (LCP) deficiency is a frequent complication in cholestic infants. We investigated the effects of LCP-supplemented formula on EFA status in infants with cholestasis. Twenty-three infants with cholestasis (biliary atresia after surgery, 8; intrahepatic cholestasis, 15) aged 1.9 to 4.9 mon (median 3.1 mon) were randomized to receive commercial infant formulas either without LCP or with LCP from egg phospholipids for 1 mon. Liver tests, nutrient intakes, and plasma phospholipid FA (p.c. w/w) were determined at baseline and after interavention. At baseline, patietns had high serum direct bilirubin levels (5.9 ń 3.0 mg/dL; mean ń SD), they were malnourished (body fat mass: 40 ń 13 p.c. of normal) and presented with PUFA deficiency [plasma phospholipid PUFA: 28.43 p.c. w/w (26.56 - 30.53) in patients vs. 37.02 p.c. w/w (34.53 - 39.58) in controls; median (f1st - 3rd quartile)] with elevated Mead acid and palmitoleic acid. LCP-supplemented (n = 11) and -nonsupplemented groups (n = 12) did not differ in age, indicators of liver function, and EFA status at baseline. After the intervention, LCP-supplemented infants had higher levels of arachidonic acid [7.2 (5.9 - 8.8) vs. 4.2 (f3.0 - 5.3) p.c. w/w; P 0.001] and DHA [2.8 (2.2 - 3.2) vs. 1.6 (1.0 - 2.1) p.c. w/w; P 0.05], accompanied by increased TBARS concentration: 1.9 (1.4 - 2.2) vs 1.3 (1.1 - 1.6) nmol/mL; P 0.05]. We concluded that LCP-supplemented formulae improve LCP status of infants with severe cholestasis but may enhance lipid peroxidation.


    1246/2523

    Tytuł oryginału: Long-term results of lower limb lengthening by physeal distraction.
    Autorzy: Zarzycki Daniel, Tesiorowski Maciej, Zarzycka Maja, Kacki Wojciech, Jasiewicz Barbara
    Źródło: J. Pediatr. Orthop. 2002: 22 (3) s.367-370, il., tab., bibligr. 15 poz.
    Sygnatura GBL: 313,480

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Of the many methods of limb elongation, lengthening by physeal distraction is among the newest. The goal of this study was to estimate the long-term results of femoral and tibial lengthening by epiphyseal distraction. The authors examined 40 patients who underwent 24 femoral and 16 tibial lengthenings. The average follow-up period was 9.6 years. An average of 4.6 cm femoral lengthening and 4.7 cm of tibial lengthening was achieved. The femoral healing index was 38.1 days/cm and the tibial healing index was 35.7 days/cm. After lengthening the epiphyseal cartilage started to functin in all patients, and premature growth cartilage fusion was not observed during follow-up. Complications occurred in eight patients during femoral lengthening and in four during tibial lengthening. The authors suggest that physeal distraction is a good method for moderate and simple limb lengthening. Particular care should be applied to knee function, especially during femoral lengthening.


    1247/2523

    Tytuł oryginału: Long-term results of lower limb lengthening by the Wagner method.
    Autorzy: Zarzycki Daniel, Tesiorowski Maciej, Zarzycka Maja, Kacki Wojciech, Jasiewicz Barbara
    Źródło: J. Pediatr. Orthop. 2002: 22 (3) s.371-374, il., tab., bibligr. 19 poz.
    Sygnatura GBL: 313,480

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Methods of limb lengthening have been continously modified. The construction of an apparatus for gradual bone distraction was a great improvement. The aim of this study was to evaluate the long-term results of lower limb elongation using the Wagner technique. Between 1983 and 1989, 45 patients underwent surgery in the authors' institution. There were 31 femoral and 15 tibial lengthenings. The operation and lengthening procedure were performed according to the rules published by the method's author. The intended amount of lengthening was achieved in 80 p.c. of patients during tibial elongation and in only 52 p.c. during femoral elongation because of many problems, obstacles, and complications during treatment. A significant percentage of improper (deficient or irregular) new bone formation led to femoral malunin in three patients and to tibial and femoral delayed bone consolidation in six patients. Fast distraction produced great forces on the surrounding joint surfaces, resulting in a limited range of motion and joint stiffness. The Wagner technique does not seem to be effective and is associated with a long duration of treatment and some complications impairing the function of the limb.


    1248/2523

    Tytuł oryginału: Education, science and quality assurance in radiotherapy in Europe.
    Autorzy: Heeren Germaine
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (1) s.7-9
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie


    1249/2523

    Tytuł oryginału: Assessment of early toxicity of concomitant radio-chemotherapy in the treatment of locally advanced cervical cancer.
    Autorzy: Wieczorek Andrzej, Kędzierawski Piotr, Smok-Kalwat Jolanta, Banatkiewicz Paweł
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (1) s.11-14, il., bibliogr. 10 poz. - Konferencja pt. Postępy w radioterapii onkologicznej - diagnostyka i leczenie, planowanie klinicznego rokowania Poznań 19-21.04. 2001
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia
  • toksykologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Introduction: The aim of this paper was to assess early toxicity and feasibility of concomitant radiochemotherapy in the treatment of locally advanced cervical cancer in daily routine clinical practise. Material and methods: Between 1st of May 2000 and 15th of November 2000, twenty one patients suffering from stage IIB and IIIB (FIGO classification) cervical carcinoma were treated in the Radiotherapy Department of the Holycross Cancer Centre by concomitant radio-chemotherapy. Early toxicity of the skin, the lower gastrointestinal system and the genitourinary system was assessed according to acute radiation morbidity scoring criteria EORTC/RTOG. Leukopenia, thrombocytopenia, anemia, nausea, vomiting and nephrotoxicity were scored according to the WHO scale. Results: There were no treatment-related deaths and no treatment breaks in radiotherapy due to acute toxicity. Only 48 p.c. of patients completed all 6 courses of cis-platin. The main causes of withdrawals from consecutive cycles of chemotherapy were: leucopenia - grade 2 or 3, thrombocytopenia - grade 3 and patient refusal. One patient developed acute renal failure. Other adverse effects did not exceed grade 2. Conclusions: Concomitant radio-chemotherapy in the treatment of locally advanced cervical cancer was feasible and featured acceptable toxicity. Haematologic adverse effects were the main reasons of discontinued chemotherapy. Radiotherapy was well tolerated and all patients completed the whole course.


    1250/2523

    Tytuł oryginału: Postmastectomy radiotherapy.
    Autorzy: Korzeniowski Stanisław
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (1) s.15-25, tab., bibliogr. 42 poz. - Konferencja pt. Postępy w radioterapii onkologicznej - diagnoza i leczenie, planowanie klinicznego rokowania Poznań 19-21.04. 2001
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia
  • chirurgia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska


    1251/2523

    Tytuł oryginału: The effect of altered fractionation schedule on the spinal cord response: radiobiological considerations.
    Autorzy: Supe Sanjay S., Ganesh K. M., Velmurugan J., Rana B. S., Sankar B. N.
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (1) s.27-35, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Increased fractionation spares late reacting normal tissued more than acute reacting normal tissues. A linear quadratic model is valid from large dose per fraction down to dose per fraction of 2 Gy. Experimental studies on animals and clinical studies on the spinal cord tolerance have shown incidences of myelopathy at doses lower than 50 Gy. The ŕ/á value of the linear quadratic model have been lower for low doses per fraction, indicating a sparing effect of altered fractionation for spinal cord myelitis. Animal data, clinical and radiobiological xplanations suggest of the radiobiological models. Further data suggest that one must not assume the spinal cord to have a greater tolerance at doses per fraction below the conventional dose per fraction of 2 Gy.


    1252/2523

    Tytuł oryginału: Tumors and the danger model.
    Autorzy: Kowalczyk Dariusz W.
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.295-302, il., bibliogr. [26] poz. - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: This article reviews the evidence for the danger model inthe context of immune response to tumors and the insufficiency of the immune system to eliminate tumor growth. Despite their potential immunogenicity tumors do not induce significant immune responses which could destroy malignant cells. According to the danger model, the immune surveillance system fails to detecttumor antigens because transformed cells do not send any danger signals which could activate dendritic cells and initiate an immune response. Instead, tumor cells or antigen presenting cells turn of the responding T cells and induce tolerance. The studies reviewed herein based on model tumor antigens, recombinant viral vectors and detection of tumor specific T cells by MHC/peptide tetramers underscore the critical role of tumor antigen presentation and the context in which it occurs. They indicate that antigen presentation only by activated but not by caner or resting dendritic cells is necessary for the induction of immune responses to tumor antigens. It becomes apparent that the inability of dendiritic cells to become activated provides a biological niche for tumor escape from immune destruction and seems to be a principal mechanisms for the failure of tumor immune surveillance.


    1253/2523

    Tytuł oryginału: Sialyl Lewis-a: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells.
    Autorzy: Ugorski Maciej, Laskowska Anna
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.303-311, il., bibliogr. s. 308-311 - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Neoplastic transformation is often associated with characteristic changes in the expressionof the sialyl Lewis**a and sialyl Lewis**x antigens, representing typical turmor-associated carbohydrate antigens. High amounts of sialyl Lewis**a are present in human adenocarcinomas of the colon, pancreas and stomach. A growing amount of data suggests that this carbohydrate structure is theligand for E-selectin. Sialylated Lewis structures present on the surface of tumor cells are carried by the carbohydrate chains of glycoproteins and glycolipids. There are several lines of evidence showing that sialyl Lewis**a is responsible for the adhesion of human cancer cells to endothelium. E-selectin present on endothelial cells mediates these interactions. Selectins and their carbohydrate ligands can thus play an important role in the selective homing of tumor cells during metastasis. However, the presence of sialyl Lewis**a antigen on the surface of tumor cells and their adhesion to E-selectin-expressing cells in in vitro adhesion assay by itself can not be directly related to metastatic properties of all cancer cells.


    1254/2523

    Tytuł oryginału: Antiangiogenic gene therapy in inhibition of metastasis.
    Autorzy: Szala Stanisław, Szary Jarosław, Cichoń Tomasz, Sochanik Aleksander
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.313-321, il., tab., bibliogr. s. 319-321 - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: This short review attempts to demonstrate the usefulness of antiangiogenic gene therapy in achieving inhibition of growth in experimentally-induced metastases. Certain normal tissues (for example skeletal muscle) may be used in vivo, after genetic modification, as a "bioreactor", able to produce and secrete into the bloodstream rpoteins known to exert antiangiogenic effects. By inhibiting neoangiogenesis these proteins would thus prevent the development of metastases. The review discusses also the perspectives of antimetastatic therapy based on certain types of allogenic cells (for example myoblasts and fibroblasts) that had been genetically modified and then microencapsulated. The strategy of encapsulation is aimed at protecting the modified cells secreting antiangiogenic factors from being eliminated by the immune system. Secretion antiangiogenic factors from being eliminated by the immune system. Secretion of antiangiogenic proteins by these microencapsulated cells can be controlled with inducible promoters. Antiangiogenic genes remaining under the transcriptional control of such promoters may be switched on and off using antibiotics, such as tetracycline derivatives, or steroid hormones.


    1255/2523

    Tytuł oryginału: Metabolic acitvation of adriamycin by NADPH-cytochrome P450 reductase; overview of its biological and biochemical effects.
    Autorzy: Bartoszek Agnieszka
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.323-331, il., tab., bibliogr. 330-331 - 8 Międzynarodowe Sympozjum nt. molekularnych aspektów chemioterapii Gdańsk 05-07.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem

    Streszczenie angielskie: NADPH-cytochrome P450 reductase (P450 reductase) is one of the enzymes implicated in the metabolism of adriamycin, a very important clinically used antitumour drug. However, apart from the enzyme involvement, so far little was known about the chemical route and biochemical effects of this process. We demonstrated that the application of P450 reductase simultaneously with adriamycin to tumour cells in culture significantly increased cytotoxicity of the drug. Under tissue culture conditions, we noticed also that, in the presence of P450 reductase, adriamycin metabolite(s), displaying an altered spectrum within the visible light range were formed. This observation was taken adavantage of to study the metabolism of adriamycin in cell-free systems, using initially the enzyme isolated from rat liver and the recently obtained recombinant human P450 reductase. The reductive conversion of the drug turned out to be a multi-stage process, which occurred only under aerobic conditions and was accompanied by excessive NADPH consumption. Further research carried out iwht the aid of radical scavengers and rafdiolabelled adriamycin revealed that the enhancement of biological acitivity of adriamycin by P450 reductase stemmed from the formation of alkylating metabolite(s) rather than from the promotion of redox cycling known to be nduced in the presence of anthracyclines.


    1256/2523

    Tytuł oryginału: Expression of PiT1 and PiT2 retroviral receptors and transduction efficiency of tumor cells.
    Autorzy: Grabarczyk Piotr, Wysocki Piotr J., Gryska Katarzyna, Mackiewicz Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.333-339, il., bibliogr. [10] poz. - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Recombinant retroviral vectors are still the most common gene delivery vehicles for gene therapy purposes, especially for construction of genetically modified tumor vaccines (GMTV). However, theses vehicles are characterized by relatively low titre and in the case of many tumor cell lines, low transduction efficiency. We constructed bicistronic retroviral vector pseudotypes of amphotropic murine leukemia virus (A-MuLV) and gibbon ape elukemia virus (GaLV), encoding enhanced green fluorescent protein (EGFP) as a rapid and easily detectable reporter gene. Transduction of five different human melanoma and four renal carcinoma cell lines by these two virus pseudotypes revealed differences in transduction efficiency, which wase markedly lower for the renal carcinoma cell lines. Stimulation of retroviral receptor expression (PiT1 and PiT2) by phosphate depletion induced a limited increase of receptor mRNA levels, but did not improve the gene transfer efficiency. In contrast, simultaneous transduction with both vector psuedotypes markedly increased the transduction efficiency, compared to GaLV or A-MuLV alone. The same effect could be achieved by several repeated exposures of target cells to fresh vector preparation. Overexpression of GaLV receptor (PiTq) in target cells significantly increased the transduction rate and enabled retrovirus mediated gene transfer into the cells which normally are not transducible by GaLV pseudotypes. We demonstrated that, using different transduction strategies, the relatively inefficient, widely used retroviral vector systems could be significantly improved.


    1257/2523

    Tytuł oryginału: Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer.
    Autorzy: Kowara Renata, Gołębiowski Filip, Chrzan Paweł, Skokowski Jarosław, Karmolinski Andrzej, Pawełczyk Tadeusz
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.341-350, il., tab., bibliogr. [32] poz. - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Searching for ways to improve the characterization of breast cancer we examined the realtionship between the status of teh FHIT gene transcript and amplification of c-myc and the c-erbB2 oncogene. Abnormal FHIT transcript was detected in 32 of 79 cancers examined. The presence of Fhit protein estimated by Western blots was evident only in cancers exhibiting a normal-sized FHIT transcript. This indicates that abnormal FHIT transcripts observed in our study did not encode any Fhit protein or the amount of such protien was very low. There was no association between the presence of aberrant FHIT gene transcirpt with age, tumor size, estrogen and progesterone receptor status, local metastases and histological grading. However, the abnormalities in FHIT gene transcripts were observed with different frequency depending on the histopathological type of the tumor. The aberrant FHIT transcript was detected in 60 p.c. of lobular cancers and only in 28 p.c. of ductal cancers. Analyzing the occurrence of c-myc and c-erbB2 amplification and the presence of aberrant FHIT gene transcripts we found that the aberrant FHIT transcirpt more frequently occurred in tissues with c-myc amplification. There was a significant (P 0.05) correlation between the occurrence of the aberrant FHIT gene transcript with accompanying c-mcy amplification and positive lymph node status. However, in order to evaluate the predictive value of these findings in breast cancer, an extended clincal follow up will be necessary.


    1258/2523

    Tytuł oryginału: Germline mutations in the BRCA1 gene predisposing to breast and ovarian cancers in Upper Silesia population.
    Autorzy: Grzybowska Ewa, Siemińska Marzena, Zientek Helena, Kalinowska Ewa, Michalska Jadwiga, Utracka-Hutka Beata, Rogozińska-Szczepka Jadwiga, Kaźmierczak-Maciejewska Maria
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.351-356, tab., bibliogr. s. 354-356 - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca epidemiologiczna

    Wskaźnik treści:
  • płeć żeńska
  • ludzie

    Streszczenie angielskie: Germline mutations in the BRCA1 or BRCA2 genes predispose their cariers to breast or/and ovary cancers during their lifetime. The most frequent mutations: 5382insC, 185delAG, C61G and 4153delA in BRCA1, and 6174delT and 9631delC in BRCA2 were studied in a group of 148 probands admitted for genetic counseling, using allele-specific amplification (ASA) PCR test. Fifteen carriers of three different mutations: 5382insC, 185delAG and C61G in BRCA1 were found. Two families carried the 185delAG mutationand additional two C61G in BRCA1. Nobody carried the mutation 4153delA in BRCA1 nor 617delT or 9631delC in BRCA2. Most of the carriers of a germline mutation were observed among the patients who developed bilateral breast cancer (17 p.c.). The lowest frequency of the germline mutations was found inthe healthy persons who had two or more relatives affected with breast or ovarian cancer.


    1259/2523

    Tytuł oryginału: Comparative analysis of prostatic acid phosphatase and prostat-specific antigen mRNA levels in hyperplastic prostate stimulated with steroid hormones and growth factors.
    Autorzy: Dulińska Joanna, Laidler Piotr, Łabędź Maria
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.357-368, il., tab., bibliogr. s. 366-368 - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) are the markers of human prostatic gland. However, it is still not completely understood if and how, steroid hormones and growth factors affect their expression and metabolism in the respect to the major pahtologies of the gland. Appropriate studies were carried out on histopathologically diagnosed benign prostatic hyperplasia - BPH (n - 42) using tissue slices and cells derived from them. They were incubated with steroid hormones: 5-ŕ-dihydrotestosterone (DHT), estradiol (E) and growth factors: epidermal growth factor (EGF), basic fibroblastic growth factor (bFGF) under culture conditiions for up to 24 hours. 32P-labelled specific oligonucleotide probes were used to analyze total RNA isolated from each sample for the presence of PAP and PSA mRNAs. DHT, E, bFGF, EGF or both DHT + bFGF and DHT + EGF increased PAP and PSA mRNA levels in a time- and dose-dependent manner. The highest and statistically significant increase (p 0.001) for PAP mRNA was observed when DHT + bFGF were present in the medium while for PSA mRNA if DHT + EGF were added to the medium.


    1260/2523

    Tytuł oryginału: Analysis of mutations in the p16/CDKN2A gene in sporadic and familial melanoma in the Polish population.
    Autorzy: Lamperska Katarzyna, Karczewska Aldona, Kwiatkowska Eliza
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.369-376, il., tab., bibliogr. s. 374-376 - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • dermatologia i wenerologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca epidemiologiczna

    Streszczenie angielskie: Mutations in CDKN2A have been found in sporadic cutaneous malignant (CMM), in familial CMM and in other syndromes associated with melanoma. In this study DNA was obtained from 207 individuals and five cell lines. There were 157 CMM patients and 50 healthy members of melanoma patients families. The CMM group included patients with one or two melanoma cases in the family, families with dysplastic nevus syndrom (DNS) and patients with a spectrum of other types of cancers in the family. PCR-SSCP analysis and sequencing identified: six substitutions in codon 58 CGA/TGA (Arg/Stop), 16 substitutions GAC/GAT in codon 84 (Asp/Asp), six substitutions CGA/TGA in codon 148 (Arg/Thr), 14 substitutions G/C in 3'UTR and 4 double changes (two in codon 84 and 3'UTR; two in codon 148 and 3'UTR). THe mutation identified in codon 58 was found in tissue only. Other substitutions were polymorphisms found in DNA from tissue and blood samples. Most of them were identified in sporadic CMM (six in codon 148 Ala/Thr, 12 in codon 84 Asp/Asp and six in 3'UTR). The frequency of the polymorphisms was also high in DNS and CMM/DNS families (four in codon 84 Asp/Asp and six in 3'UTR). No mutations or polymorphisms were found in CMM patients with one or two melanoma cases and CMM patients, with other cancers in family history. The analysis of the CDKN2A gene muataions in the Polish population demonstrated: (i) no germline mutations; (ii) a relatively high number of genetic changes in sporadic melanoma; (iii) a high number of polymorphisms in DNS and CMM/DNS families.


    1261/2523

    Tytuł oryginału: Expression of p16 in sporadic primary uveal melanoma.
    Autorzy: Lamperska Katarzyna, Mackiewicz Krystyna, Kaczmarek Aldona, Kwiatkowska Eliza, Starzycka Maria, Romanowska Bożena, Heizman Janina, Stachura Jerzy, Mackiewicz Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.377-385, il., tab., bibliogr. s. 383-385 - 37 Spotkanie Polskiego Towarzystwa Biochemicznego Toruń 10-14.09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • okulistyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Expression of p16 protein, intragenic mutations of CDKN1A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (RS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15 p.c. of cases less than 10 p.c. of melanoma cells were p16 positive, in 70 p.c. of cases less than 50 p.c. of cells, while in 7 p.c. more than 80 p.c. of cells stained for p16 (mean IRS for all cases was 4.87 ń 2.43). In B type the IRS was 8.5 ń 0.7, in A + B type 6.0 ń 2.1 and in the mixed type 4.17 ń 2.43). In B type the IRS was 8.5 ń 0.7, in A + B type 6.0 ń 2.1 and in the mixed type 4.17 ń 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean (IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma.


    1262/2523

    Tytuł oryginału: Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.
    Autorzy: Urbańska Krystyna, Romanowska-Dixon Bożena, Matuszak Zenon, Oszajca Janusz, Nowak-Śliwińska Patrycja, Stochel Grażyna
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.387-391, il., bibliogr. [9] poz. - 5 Sympozjum nt. wolnych rodników w biologii i medycynie Łódź 07-10.06. 2000
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (lambda ex = 830nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.


    1263/2523

    Tytuł oryginału: Side-chain modified vitamin D analogs require activation of both PI 3-K and erk 1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells.
    Autorzy: Marcinkowska Ewa, Kutner Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.393-406, il., tab., bibliogr. s. 404-406
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Synthetic analogs of vitamin D for potential use in differentiation therapy should selectively regulate genes necessary for differentiation without inducing any perturbations in calcium homeostasis. PRI-1906, an analog of vitamin D2, and PRI-2191, an analog of vitamin D3 bind nuclear vitamin D receptor (nVDR) with substantially lower affinity than 1,25-dihydroxyvitamin D3 (1,25-D3), but have higher differentiation-inducing activity as estimated in HL-60 leukemia cell model. To examine how their increased differentiation-inducing activity is regulated we tested the hypothesis that membrane-mediated events, unrelated to nVDR, take part in the differentiation in response to PRI-1906 and PRI-2191. The induction of leukemia cell differentiation in response to the analogs of vitamin D was inhibited by LY294002 (phosphatidylinositol 3-kinase inhibitor), PD 98059 (inhibitor of MEK1,2, an upstream regulator of extracellular-signal regulated kinase) and rapamycin (p70S6K inhibitor) pointing out that activation of signal transduction pathways unrelated to nVDR is necessary for differentiation. On the other hand, inhibition of cytosoloic phospholipase A2 accelerated the differentiation of HL-60 cells induced by either 1,25-D3 or by the vitamin D analogs suggesting possible existence of a feedback loop between extracellular-signal regulated kinases and phospholipase A2.


    1264/2523

    Tytuł oryginału: Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.
    Autorzy: Pawełczak Krzysztof, Makowski Maciej, Kempny Michał, Dzik Jolanta M., Gołos Barbara, Rode Wojciech, Rzeszotarska Barbara
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.407-420, il., tab., bibliogr. s. 418-420 - 1046 Międzynarodowe Sympozjum nt. biologii i chemii pochodnych pterydyny i folionówMiędzynarodowe Sympozjum nt. molekularnych aspektów chemioterapiiMiędzynarodowy Kongres nt. leczenia przeciwnowotworowego Orange BeachGdańskParyż 199319931996
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Synthesis and biological evaluation are described of seven new analogues (309) of two potent thymidylate synthase inhibitors, 10-propargyl-5,8-dideazafolate (1) and its 2-methyll-2-deamino congener ICI 198583 (2). While the new compounds 3 and 4 were analogues of 1 and 2, respectively, containing a p-aminobenzenesulfonyl residue in place of the p-aminobenzoic acid residue, the remaining 5 new compounds were analogues of 4 with the L-glutamic acid residue replaced by glycine (5), L-valine (6), L-alanine (7), L-phenylglycine (8) or L-norvaline (9). The new analogues were tested as inhibitors of thymidylate synthases isolated from tumour (Ehrilich carcinoma), parasite (Hymenolepis diminuta) and normal tissue (regenerating ratliver) and found to ve weaker inhibitors than the parent 10-propargyl-5,8-dideazafolic acid. Selected new analogues, tested as inihbitors of growth of mouse leukemia L 5178Y cells, were less potent than the parent 10-propargyl-5,8-dideazafolic acid. Substitution of the glutamyl residue in compound 4 with L-norvaline (9) resulted in only a 5-fold stronger thymidylate synthase inhibitor, but a 40-fold weaker cell growth inhibitor.


    1265/2523

    Tytuł oryginału: Molecular cloning and sequencing of partial cDNA of tumor necrosis factor and p75 tumor necrosis factor receptor of Syrian golden hamster (Mesorcricetus auratus) with the use of universal primers.
    Autorzy: Dobrzańska Zuzanna, Więckiewicz Joanna, Bigda Jacek
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.427-431, il., bibliogr. [15] poz. - 6 Spotkanie Młodych Immunologów Sekcji Polskiego Towarzystwa Immunologii Doświadczalnej i Klinicznej Gdańsk 2000
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca doświadczalna
  • komunikat

    Wskaźnik treści:
  • zwierzęta
  • chomiki
  • płeć męska

    Streszczenie angielskie: In this study we cloned and analysed partial cDNA of tumor necrosis factor (TNF) and p75 TNF-R receptor of Syrian golden hamster (Mesocricetus auratus). We obtained a 382-bp sequence of TNF and a 148-bp sequence coding for p75 TNF-R. The primers used for the cloning were designed on the basis of inter-species homology, thus presumably can be used for cloning and analysis of TNF and p75 TNF-R genes of other mammals.


    1266/2523

    Tytuł oryginału: Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans.
    Autorzy: Gajko-Galicka Anna
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.433-441, il., tab., bibliogr. s. 439-441
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Osteogeneis imperfecta (OI), commonly known as "brittle bone disease", is a dominant autosomal disorder characetrized by bone fragility and abnormalities of connective tissue. Biochemical and molecular genetic studies have shown that the vast majority of affected individuals have mutations in either the COL1A1 or COL1A2 genes that encode the chains of type I procollagen. OI is associated with a wide spectrum of phenotypes varying from mild to severe and lethal conditions. The mild forms are usually caused by mutations which inactivate one allele of COL1A1 gene and result in a reduced amount of normal type I collagen, while the severe and lethal forms result from dominant negative mutations in COL1A1 or COL1A2 which produce structural defects in the collagen molecule. The most common mutations are substitutions of glycine residues, which are crucial to formation and function of the collagen triple helix, by larger amino acids. Although type I collagen is the major structural protein of both bone and skin, the mutations in type I collagen genes cause a bone disease. Some reports showed that the mutant collagen can be expressed differently in bone and in skin. Since most mutations identified in OI are dominant negative, the gene therapy requires a fundamentally different approach from that used for genetic-recessive disorders. The antisense therapy, by reducing the expression of mutant genes, is able to change a structural mutation into a null mutation, and thus convert severe forms of the disease into mild OI type I.


    1267/2523

    Tytuł oryginału: A novel Gly to Arg substitution at position 388 of the ŕ1 chain of type I collagen in lethal form of osteogenesis imperfecta.
    Autorzy: [Gajko]-Galicka Anna, Wołczyński Sławomir, Leśniewicz Ryszard, Chyczewski Lech, Gindzieński Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.443-450, il., bibliogr. s. 449-450
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna
  • praca epidemiologiczna

    Wskaźnik treści:
  • płód
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska
  • ludzie

    Streszczenie angielskie: Cultured skin fibroblasts from a proband with a lethal form of osteogenesis imperfecta produce two forms of type I collagen chains, with normal and delayed electrophoretic migration; collagen of the proband's motehr was normal. Peptide mapping experiments localized the structural defect in the proband to ŕ1(I) CB8 peptide in which residues 123 to 402 are spaned. Direct sequencing of amplified cDNA covering this region revealed a G to A single base change in one allele of the ŕ1(I) chain, that converted glycine 388 to arginine. Restriction enzyme digestion of the RT-PCR product was consistent with a heterozygous COL1A1 mutation. The novel mutation conforms to the linear gradient of clinical severity for the ŕ1(I) chain and results in reduced thermal stability by 3řC and intracellular retention of abnormal molecules.


    1268/2523

    Tytuł oryginału: Collagen of umbilical cord vein and its alterations in pre-eclampsia.
    Autorzy: Romanowicz Lech, Jaworski Stefan
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.451-458, il., bibliogr. s. 456-458
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The state of the vascular system of the mother and of placenta is known to exert a great influence on intrauterinal development of the fetus. Pre-eclampsia is the most common pathological syndrome connected with pregnancy. Since collagen is one of the main constituents of the vessel wall a comparison was made with collagen content and its molecular polymorphism in umbilical cord veins of newborns from healthy and pre-eclamptic mothers. It was found that umbilical cord veins of newborns from mothers with pre-eclampsia contained 18 p.c. less collagen than those of the newborns from normal pregnancies. This decrease was accompanied by a sligh decrease of collagen solubility, but all its types (I, III, IV, V and VI) were present. However, the umbilical vein wall of newborns from mothers with pre-eclampsia contained relatively less of type I and more of type III collagen than the normal umbilical cord. These differences may be connected with a disturbance of blood flow in fetus of a woman with pre-eclampsia.


    1269/2523

    Tytuł oryginału: Insight into the kinetics and the mode of the interaction between smooth muscle calponin and F-actin.
    Autorzy: Kołakowski Janusz, Dąbrowska Renata
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.471-479, il., tab., bibliogr. s. 478-479
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Kinetics of the smooth muscle calponin-F-actin interaction was studied by stopped-flow measurements of light scattering and fluorescence intensity of pyrene-labelled F-actin. The intensity and character of the changes in light scattering, and thus the mode of calponin binding to actin filaments leading to changes in their shape and bundling, depend on the molar ration of the two proteins. Parallel measurements of pyrene-fluorescence quenching upon calponin binding revealed that intrinsic conformational changes in actin filaments are delayed relative to the binding process and are not markedly influenced by the mode of calponin binding. Bundling of actin filaments by calponin was not correlated with fluorescence changes and thus with alterations in the structure of actin filaments.


    1270/2523

    Tytuł oryginału: Interaction of glycophorin A with lectins as measured by surface plasmon resonance (SPR).
    Autorzy: Krotkiewska Bożena, Pasek Marta, Krotkiewski Hubert
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.481-490, il., tab., bibliogr. s. 489-490
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Glycophorin A (GPA), the major sialoglycoprotien of the human erythrocyte membrane, was isolated from erythrocytes of healthy individuals of blood groups A, B and O using phenol-water extraction of erythrocyte membranes. interaction of individual GPA samples with three lectins (Psathyrella velutina lectin, PVL; Triticum vulgaris lectin, WGA and Sambucus nigra I agglutinin SNA-I) was analyzed using a BIAcore**TM biosensor equipped with a surface plasmon resonance (SPR) detector. The experiments showed no substantial differences in the interaction between native and desialylated GPA samples originating from erythrocytes of either blood group and each of the lectins. Desialylated samples reacted weaker than the native ones with all three lectins. PVL reacted about 50-fold more srongly than wGA which, similar to PVL, recognized GlcNAc and Neu5Ac residues. SNA-I lectin, recognizing ŕ2-6 linked Neu5Ac residues, showed relatively weak reaction with native and only residual reaction with desialylated GPA samples. The data obtained show that SPR is a valuable method to determine interaction of glycoproteins with lectins, which potentially can be used to detect differences in the carbohydrate moiety of individual glycoprotein samples.


    1271/2523

    Tytuł oryginału: The structure of the oligosaccharides of ŕ3á1 integrin from human ureter epithelium (HCV29) cell line.
    Autorzy: Lityńska Anna, Pocheć Ewa, Hoja-Łukowicz Dorota, Kremser Elżbieta, Laidler Piotr, Amoresano Angela, Monti Chiara
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.491-500, il., tab., bibliogr. s. 499-500
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: There is a growing line of evidence that glycosylation of ŕ and á subunits is important for the function of integrins. Integrin ŕ3á1, from human ureter epithelium cell - line HCV29, was isolated by affinity chromatography on laminin GD6 peptide. Characterization of its carbohydrate moieties was carried out using sodium dodecyl sulfate/polyacrylamide gel electrophoresis followed by Western blotting on Immobilon P and on-blot deglycosylation with peptide N-glycosidase-F. Profiles of N-glycans for each subunit were obtained by matrix-assisted laser desorption/ionization mass spectrometry. Our findings demonstrated, in both subunits of integrin ŕ3á1, the presence of complex type oligosaccharides with a wide heterogeneity. Bi-tri- and tetraantennary structures were the most common, while hig-mannose type structures were minor. Also the presence of short poly-N-acetyllactosamine entities was shown. These results show that while tha predominant oligosaccharides of both subunits are identical, some slight differences between them do exist.


    1272/2523

    Tytuł oryginału: The ç-glutamyltransferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups.
    Autorzy: Włodek Przemysław, Sokołowska Maria, Smoleński Olgierd, Włodek Lidia
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.501-507, il., bibliogr. s. 506-507
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: The present work was aimed to obtain information about age-dependent changes of ç-glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl compounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated. The results indicate that the activity of GGT and NPSH levels in the kidneys are reduced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the oldest animals. These findings indicate that the capacity for extracellular glutathione degradation adn, in consequence, the availability of cysteine for intracellular glutathione biosynthesis may be impaired. The increased PB-Cys level indicates potentiation of the thiolation reaction, i.e. development of protein-mixed disulfides. These results reveal age dependent disturbances in the thiol-disulfide equilibrium in the dineys which leads to an imbalance between pro- and antioxidatory processes.


    1273/2523

    Tytuł oryginału: Spectrophotometric method for the determination of renal ouabain-sensitive H+, K+ -ATPase activity.
    Autorzy: Bełtowski Jerzy, Wójcicka Grażyna
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.515-527, il., tab., bibliogr. s. 526-527
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of this work was to develop a method for renal H+, K+ -ATPase measurement based on the previously used Na+, K+ -ATPase assay (Bełtowski et al.: J Physiol Pharmacol.; 1998, 49: 625-37). ATPase activity was assessed by measuring the amount of inorganic phosphate liberated from ATP by isolated microsomal fraction. Both ouabain-sensitive and ouabain-reistant K+ - stimulated and Na+ -independent ATPase activity was detected in the renal cortex and medulla. These activities were blocked by 0.2 mM imidazolpyridine derivative, Sch 28080. The method for ouabainsensitive H+, K+ -ATPase assay is characterized by good reproducibility, linearity and recovery. In contrast, the assay for ouabain-resistant H+, K+ -ATPase was unsatisfactory, probably due to low activity of this enzyme. Ouabain-sensitive H+, K+ -ATPase was stimulated by K+ with Km of 0.26 ń 0.04 mM and 0.69 ń 0.11 mM in cortex and medulla, respectively, and was inhibited by ouabain (Ki of 2.9 ń 0.3 ćM in the renal cortex and 1.9 ń 0.4 ćM in the renal medulla) and by Sch 28080 (Ki of 1.8 ń 0.5 ćM and 2.5 ń 0.9 ćM in cortex and medulla, respectively). We found that ouabain-sensitive H+, K_ -ATPase accounted for about 12 p.c. of total ouabain-sensitive activity in the Na+, K+ -ATPase assay. Therefore, we suggest to use Sch 28080 during Na+, K+ -ATPase measurement to block H+, K+ -ATPase and improve the assay specificity. leptin administered intraperitoneally (1 mg/kg) decreased renal medullary Na+, K+ -ATPase activity by 32.1 p.c. at 1 h after ijection but had no effect on H+, K+ -ATPase activity suggesting that the two renal ouabain-sensitive ATPases are separately regulated.


    1274/2523

    Tytuł oryginału: Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits.
    Autorzy: Gumieniczek Anna, Hopkała Hanna, Wójtowicz Zbigniew, Nikołajuk Justyna
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.529-535, tab., bibliogr. s. 534-535
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • króliki
  • płeć męska
  • zwierzęta

    Streszczenie angielskie: The present study was designed to evaluate the oxidative stress-related parameters in alloxan-induced diabetes in rabbits. After 3, 6, 12 and 24 weeks of hyperglycaemia the enzymatic and non-enzymatic factors were measured in heart tissue fo diabetic and control groups. Superoxide dismutase and glutathione peroxidase activities and the contents of total sulfhydryl compounds signficantly increased at all time intervals. Catalase activity increased initially (after 3 and 6 weeks), decreased after 12 weeks and increased again at the 24th week of the experiment. Glutathione reductase activity increased initially (at 3rd week), decreased below control level after 6 and 12 weeks, then increased again. Ascorbic acid concentration decreased after 3 and 6 weeks, and increased at the 12th and 24th weeks. The level of lipid peroxidation products was reduced after 3, 6 and 12 weeks of the experiment. After 24 weeks it was significantly elevated. These data suggest that hyperglycaemia induces oxidative stress in the heart but the defense mechanisms in the heart tissue are fairly efficacious against oxidative injury.


    1275/2523

    Tytuł oryginału: 10th anniversary of the UNESCO/Polish Academy of Sciences Cellular and Molecular Biology Network.
    Autorzy: Rędowicz M. Jolanta
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.547-549
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • informator
  • tytuł obcojęzyczny


    1276/2523

    Tytuł oryginału: Upregulation of fatty acid synthase gene expression in experimental chronic renal failure.
    Autorzy: Szołkiewicz Marek, Niewęgłowski Tomasz, Korczyńska Justyna, Sucajtys Elżbieta, Stelmańska Ewa, Goyke Elżbieta, Świerczyński Julian, Rutkowski Bolesław
    Źródło: Metabolism 2002: 51 (12) s.1605-1610, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 303,583

    Hasła klasyfikacyjne GBL:
  • genetyka
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Hypertriglyceridemia associated with chronic renal failure (CRF) and elevated plasma concentration of very-low-density lipoprotein (VLDL) are thought to be a consequence of the depressed lipoprotein lipase and hepatic lipase activities and impaired clearance of lipoproteins. However, ther is some evidence that the lipoproteins overproduction might also contribute to hypertriglyceridemia in CRF. This study was performed to test the hypothesis that the increased rate of lipogenesis consequent to upregulation of fatty acid synthase (FAS), a key lipogenic enzyme, gene expression could contribute to overproduction of triacylglycerols and to hypertriglyceridemia in CRF. FAS activity, FAS protein mass (Western nlot analysis), and FAS mRNA level (Northern blot analysis) in liver and epididymal white adipose tissue (WAT) were measured in male Wistar rats 6 weeks after subtotal (5 of 6) nephrectomy or shan operation. Moreover, the rate of lipogenesis in WAT was determined. The CRF group showed significant increase in FAS gene expression (measured as activity, mRNA, and protein abudance) in both liver and WAT. This was associated with the increase in the lipogenesis rate and with the increase in plasma triacylglycerol and VLDL concentrations. Our results suggest that not only decreased removal, but also an increase of triacylglycerol production could contribute, in part, to the CRF-associated hyperlipidemia. Upregulation of FAS gene expression, shown in this report for the first time, reveals another factor involved in disturbed lipid metabolism in CRF....


    1277/2523

    Tytuł oryginału: Morphological lesions detected by light and electron microscopies in chronic type B hepatitis.
    Autorzy: Kasprzak Aldona, Biczysko Wiesława, Adamek Agnieszka, Zabel Maciej
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.103-115, il., tab., bibliogr. 90 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Apart from serologicla daignosis of chronic type B hepatitis, of high importance is specific morphological diagnosis, based on evaluation of liver biopsies. In the evaluation, the techniques are employed, which directly visualize the virus in the cells (electron microscopy) as well as the techniques of cell biology which demonstrate the presence of viral genetic material and viral proteins in situ. This paper reviews the available data on the diagnosis of liver pathomorphology using the above mentioned techniques in chronic HBV infections in adults. The data have been compared with the results of our own studies, performed in children. In chronic type B hepatitis and more frequently in children than in adults, slight or moderate inflammation (grade 1 to 2) and insignificantly advanced fibrosis (stage 1 to 2) are noted in the liver. Both in children and in adults, lesions in hepatocyte nuclei represent the common morphological denominator in the patterns of light and electron microscopy. The cell nuclei are of variable size, irregular shape, they stain irregularly, manifest an altered outline of nuclear envelope, frequently exhibit numerous and enlarged cell nucleoli and chromatin dissociation (the so called empty cell nuclei). In ultrastructural studies, hepatocyte cytoplasm contains Dane's bodies and tubular forms of HBsAg while virus-resembling particles are noted in cell nuclei. Molecular biology techniques (immunocytochemistry, in situ hybiridisation) reveals nuclear and/or cytoplasmic location of HBcAg, cytoplasmic location of HBsAg and a similar location of HBV DNA. THe data permit us to determine precisely the stage of infection and to make appropriate therapeutic decisions.


    1278/2523

    Tytuł oryginału: Morphological and immunological features of liver inflammatory infiltrate in children with chronic hepatitis C.
    Autorzy: Woźniakowska-Gęsicka Teresa, Wiśniewska-Ligier Małgorzata, Kałużyński Andrzej, Turant Maria
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.117-122, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to assess the correlation between morphological and immunological features of lesions in the liver in children with chronic hepatitis C. In the study 11 children with chronic hepatitis C were enrolled. Histopathological and immunomorphological investigations included antigen marking CD45, CD45RA, CD45RO, CD20, CD3, CD8 in liver biopsy specimens. The immunomorphological assessment of the inflammatory infiltrate cells showed the presence of CD45 antigen on the vast majority of leukocytes in the portal tracts and in the lobular parenchyma in all the studied children. One fourth of the inflammatory cells were characterised by CD20 phenotype, 1/2 - by CD3 phenotype, 1/3 - by CD8phenotype, 1/3 - by CD45RA phenotype and 2/3 - by CD45RO phenotype. Conclusions: T and B lymphocytes were predominant in hepatic inflammatory infiltrates (T lymphocytes are twice as numerous as B lymphocytes). Among T lymphocytes, cytotoxic and suppressor cells were prevailing. Most T lymphocytes were characterized by CD45RO phenotype, which shows their activation. A positive correlation between most lymphoid cell markers, staging and grading suggests the role of these cells in liver injury.


    1279/2523

    Tytuł oryginału: Expression of vascular endothelial growth factor (VEGF) in human thyroid tumors.
    Autorzy: Lewy-Trenda Iwona, Wierzchniewska-Ławska Agnieszka
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.129-132, tab., bibliogr. 45 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • onkologia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Vascular endothelial growth factor (VEGF) is one of the factors related to angiogenesis of tumors and physiological and pathological proliferative processes. Location of VEGF in human thyroid tissue with various thyroid disorders was studied in order to explore its possible involvement in proliferative processes. Immunohistochemical examination was performed on 69 formalin-fixed, paraffin-embedded thyroid tissue specimens using the labelled streptoavidin biotin peroxidase complex detection system. VEGF was not identified in normal thyroid follicular cells. Some but not all tumor thyreocytes expressed VEGF in cytoplasm. VEGF positive expression was found in 6/15 patients with papillary carcinoma, 4/9 with follicular carcinoma, 14/28 with follicular adenoma and 2/17 with adenomatous goiter. In benign follicular adenoma and adenomatous goiter the weak expression of VEGF was found in small areas of the tumor tissues, whereas in malignant tumors it was found strongly in many cells. VEGF probably functions as a hypoxia-inducible angiogenic factor, and the expression of VEGF is stronger in malignant tumors, which need more oxygen supply to proliferate. An intensive VEGF production by differentiated thyroid carcinomas could be a promising marker of tumor aggressiveness and may also be useful as a predictor of metastatic potential and extension of tumor mass.


    1280/2523

    Tytuł oryginału: The effect of cisplatin, etoposide and quercetin on Hsp72 expression.
    Autorzy: Jakubowicz-Gil Joanna, Paduch Roman, Gawron Antoni, Kandefer-Szerszeń Martyna
    Źródło: Pol. J. Pathol. 2002: 53 (3) s.133-137, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Heat shock protein 72 (Hsp72) belongs to a group of proteins referred to as molecular chaperones that protect normal and tumoru cells against many stressors such as hyperthermia, some commonly used chemotherapeutics and other apoptotic stimuli. Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF). Our results indicated that Hsp72 expression was drug and cell-type specific. Cisplatin and etoposide did not induce Hsp72 expression in any tumour cells but cisplatin alone induced Hsp72 expression in normal human fibroblasts. Quercetin inhibited heat shock protein expression in Hep-2 cells but induced in HSF. In thermally shocked tumour cells, the expression of Hsp72 was not altered by cisplatin and etoposide, but in normal HSF cells enhanced expression in normal and tumour cells.


    1281/2523

    Tytuł oryginału: M. D. Program Catalogue and Student Guide
    Opracowanie edytorskie: Chyczewska Barbara (ed.), Shaw John Geoffrey (ed.), Tandyrak Mirosława (ed.).
    Źródło: - Poznań, University Publishing Office Karol Marcinkowski University of Medical Sciences 2002, 87, [1] s. : il., 22 cm.
    Sygnatura GBL: 735,681

    Typ dokumentu:
  • tytuł obcojęzyczny
  • informator

    Temat korporatywny:
  • Akademia Medyczna w Poznaniu


    1282/2523

    Tytuł oryginału: General physics a brief guide
    Autorzy: Kubisz Leszek, Tuliszka Marek
    Opracowanie edytorskie: Limanowska-Shaw Honorata (przedm.).
    Źródło: - Poznań, Dział Wydaw. Uczelnianych AM 2002, 64 s. : il., 24 cm.
    Sygnatura GBL: 735,685

    Typ dokumentu:
  • tytuł obcojęzyczny


    1283/2523

    Tytuł oryginału: Origins of biomechanics : factors of regress and progress
    Opracowanie edytorskie: Kornecki Stefan (ed.).
    Academy of Physical Education in Wrocław, Polish Society of Biomechanics
    Źródło: - Wrocław, Wydaw. AWF 2002, 95, [2] s. : il., tab., bibliogr. [przy ref.], 24 cm. - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Seria: Studia i Monografie/AWF we Wrocławiu 63
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1284/2523

    Tytuł oryginału: Cases in musculoskeletal biomechanics : research, answers to scientific questions and solutions to clinical problems
    Autorzy: Perre Georges Van der
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.7-13, bibliogr. s. 12-13 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1285/2523

    Tytuł oryginału: Myofsacial force transmission as a factor of regress and progress
    Autorzy: Huijing Peter A.
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.15-27, il., bibliogr. s. 24-27 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • in vitro


    1286/2523

    Tytuł oryginału: Milestones of progress in research methods in biomechanics
    Autorzy: Morawski Janusz M.
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.29-42, il., bibliogr. s. 41-42 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1287/2523

    Tytuł oryginału: An attempt at creating a mathematical and an artificial neural network models of a simple upper extremity movement
    Autorzy: Wit Andrzej, Wychowański Michał
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.43-54, il., tab., bibliogr. s. 53-54 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca doświadczalna
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska


    1288/2523

    Tytuł oryginału: Matching the force requirements in human spine modelling
    Autorzy: Acar B. Serpil, Grilli Susannah L.
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.55-61, il., bibliogr. s. 60-61 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie


    1289/2523

    Tytuł oryginału: Problems of forensic biomechanics
    Autorzy: Erdmann Włodzimierz Stefan
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.63-68, bibliogr. s. 67-68 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • prawo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1290/2523

    Tytuł oryginału: Postural sway vs. postural strategies in quiet standing
    Autorzy: Kuczyński Michał
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.69-75, il., bibliogr. s. 74-75 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1291/2523

    Tytuł oryginału: Prediction of muscle forces for fast and slow elbow motions using different objective functions
    Autorzy: Raikova Rositsa
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.77-82, il., bibliogr. s. 81 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie


    1292/2523

    Tytuł oryginału: Computational modelling of the human head and neck motion using working model 4D
    Autorzy: Lopik David van, Acar Memis
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.83-91, il., tab., bibliogr. s. 90-91 - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie


    1293/2523

    Tytuł oryginału: Modelling force application to unstable surroundings
    Autorzy: Kornecki Stefan, Szczerban Emilia
    Źródło: W: Origins of biomechanics : factors of regress and progress - Wrocław, 2002 s.93-95, il., bibliogr. [2] poz. - 13 Międzynarodowe Seminarium pt. Podstawy biomechaniki - czynniki cofania się i postępu Wrocław 05-07.10. 2001
    Sygnatura GBL: 735,614

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska


    1294/2523

    Tytuł oryginału: Characterization of Clostridium perfringens strains isolated from Polish patients with suspected antibiotic-associated diarrhea.
    Autorzy: Pituch Hanna, Braak Nicole van den, Belkum Alex van, Leeuwen Willem van, Obuch-Woszczatyński Piotr, Łuczak Mirosław, Verbrugh Henri, Meisel-Mikołajczyk Felicja, Martirosian Gayane
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.BR85-BR88, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of our research was to investigate the role of enterotoxin- producing anaerobic bacteria other than Clostridium difficile in the etiology of antibiotic-associated diarrhea. THis article presents data related to C. perfringens. Material/Methods: Stool samples taken from 158 patients with suspected antibiotic-associated diarrhea were specifically cultured for Clostridium difficile, Bacteroides fragilis and Clostridium perfringens. In order to associate the presence of virulence factors in the bacterial isolated thus collected with disease features, all strains were genetically and phenotypically analyzed for toxin production. All isolated C. perfringens strains were cultured in Ellner sporulation-promoting medium. Results: In 21 of the 158 patients (13 p.c.) C. perfringens could be cultivated from the fecal specimen. None of the strains produced eneterotoxin, and consequently the cpe gene was not detected by PCR in any of these strains. C. perfringens and C. difficile were cultivated from the same stool samples in 4 cases. Interestingly, in one case toxin A-negative/toxin B positive C. difficile and nonenterotoxigenic C. perfringens were co-cultured. After application of a heat shock (100řC at 30 min.) only two C. perfringens strains producing thermoresistant spores were detected. Pulsed field gel electrophoresis (PFGE) demonstrated genetic heterogenicity among the C. perfringens strains, suggesting that these bacteria were already presented upon hospital admission. Conclusion: It seems unlikely that nosocomial transfer has taken place. The relatively low incidence suggests that C. perfringens is not a major primary cause of antibiotic-associated diarrhea.


    1295/2523

    Tytuł oryginału: Distinct regions of loss of heterozygosity on 22q at different sites of head and neck squamous cell carcinomas.
    Autorzy: Reis Patricia Pintor dos, Poli-Frederico Regina C‚lia, Santos Rodrigo Mattos dos, Nishimoto Ines Nobuko, Kowalski Luiz Paulo, Rogatto Silvia Regina
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.BR89-BR94, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia
  • stomatologia
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Frequent loss of heterozygosity (LOH) has been reported in many types of cancer, including head and neck carcinomas. Somatic deletions involving specific chromosomal regions are strongly associated with inactivation of the allele of a tumor suppressor gene located within the deleted region. In most studies concerning LOH in head and neck squamous cell carcinomas (HNSCC) the different anatomical sites are not distinguished. The behavior of tumors arising at various sites differs significantly, however, suggesting different intrinsic tumor propoerties. In this study we compared the LOH on 22q and its relationship to clinciopathological parameters at the three major sites of HNSCC: oral cavity, larynx and pharynx. Material/Methods: LOH and microsatellite instability (MSI) were studied using seven polymorphic microsatellite markers mapped to the 22q11-q13.3 region in 37 oral, 32 laryngeal, and 31 pharyngeal carcinomas. Results: Two separate regions of LOH were identified in the laryngeal (22q11.2-12.1) and oral cavity (22q13.1-13.31) tumors. When the different anatomical sites were compared, a statistically significant difference was found between the presence of LOH at D22S421 (p 0.001), D22S315 (p = 0.014) and D22S929 (p = 0.026) in the laryngeal tumors. Conclusions: These data suggest that distinct regions on 22q are involved in LOH in oral cavity and laryngeal tumorigenesis, but do not support a similar association between the development of pharyngeal tumors and genes located on 22q. These findings implicate the presence of different tumor suppressor genes maping to distinct regions on chromosome 22q in oral and layrngeal carcinomas.


    1296/2523

    Tytuł oryginału: Loss of heterozygosity in primary lung cancer using laser capture microdissection and WAVE DNA fragment analysis techniques.
    Autorzy: Zhu Weigang, Zou Helen, Beck Amy, Chervinsky Dave, Malik Debbie, Brooks John J., Tan Dongfeng
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.BR95-BR99, il., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: A number of molecular changes observed by varied conventional methods, including loss of heterzygosity (LOH) on chromosome 3, have been associated with primary lung cancer. To further define the locus of chromosome 3p allele loss in lung cancer, we performed LOH study by using innovative laser capture microdissection and WAVE DNA Fragment Analysis. Mateiral/Methods: Thirty-eight paired specimens from patients with adenocarcinoma of the lung were used for this study. Formalin-fixed, paraffin-embedded tissue from normal stromal cells or lymphocytes and adenocarcinoma were collected using laser capture microdissection. DNA was extracted and amplified by PCR using six polymorphic DNA markers for chromosome 3. PCR products were analyzed by both gel electrophoresis and WAVE DNA Fragment Analysis. Results: LOH at 3p22-24 was found in tumor cells from twelve out of thirty-eight patients (32 p.c.) when analyzed by WAVE DNA Fragment Analysis and LOH was found in tumor cells from nine out of thirty-eight patients (23 p.c.) when analyzed by gel electrophoresis. LOH was found in normal control from one out of thirty-eight patients. Conclusions: 1. Our results suggest putative tumor suppressor gene(s) is present in a region at 3p22-24, which may play a role in carcinogenesis of lung cancer. 2. Laser capture microdissection is essential tool for defined LOH studies. 3. WAVE DNA Fragment Analysis is an accurate, sensitive and automated tool for analysis of DNA fragments.


    1297/2523

    Tytuł oryginału: Resistance of Klebsiella pneumoniae strains producing and not producing ESBL (extended-spectrum beta-lactamase) type enzymes to selected non-beta-lactam antibiotics.
    Autorzy: Sękowska Alicja, Janicka Grażyna, Kłyszejko Czesław, Wojda Małgorzata, Wróblewski Marcin, Szymankiewicz Maria
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.BR100-BR104, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Bacteria of the Klebsiella genus may cause numerous infections in human, which are often treatead with beta-lactam antibiotics. The fundamental mechanism of Klebsiella resistance to penicillns or cephalosporins involves the production of enzymes - extended-spectrum beta-lactamases (ESBLs). Because of resistance of many Klebsiella spp. strains to beta-lactams, alternative antibiotic therapy can make use of aminoglycosides and quinolones. Material/Methods: The study analyzed the prevalence of ESBL - type enzymes among 256 Klebsiella pneumoniae strains isolated from various clinical materials collected from patients hospitalized between 1997 and 2000. ESBLs were detected by double-disk synergy test (DDST). The prevalence of strains resistant to selected aminoglycosides (gentamicin, amikacin, netilmicin) and quidolones (ciprofloxacin, norfloxacin, nalidixic acid) in the particular years was analysed. Drug sensitivity was determined by disk-diffusion method according to the recommendations of the National Reference Center for Microbial Drug Sensitivity. Results: During the analyzed time interval, a significant increase of the number of K. pneumoniae ESBL(+) strains was noted: in 1997 - 16.5 p.c. (14/85) and in 2000 - 40.4 p.c. (22/54) (p 0.001). Among the ESBL (+) strains, an increase of the number of starins resistant to the tested antibiotics, excepto for anlidixic acid, was demonstrated. Conclusion: A statistically significant increase of multidrug-resistant K. pneumoniae strains, including strains producing ESBLs, was demosntrated in the analyzed material.


    1298/2523

    Tytuł oryginału: Effect of oral supplementation of free amino acids in type 2 diabetic patients - a pilot clinical trial.
    Autorzy: Sulochana Konerirajapuram Natarajan, Lakshmi Soundarajan, Punitham Ranganathan, Arokiasamy Tharigopala, Sukumar Baluswamy, Ramakrishnan Sivaramakrishna
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR131-CR137, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Oral amino acid intake reduces plasma glucose in Streptozotocin-induced diabetic rats. This study examined the effect of oral amino acid supplementation in patients with type 2 diabetes mellitus (DM). Material/Methods: A double blind pilot clinical trail was conducted for a period of 2 moonths on 77 subjects with type 2 DM. Subjects of both sexes, ages 30-60, were included in the trial. All were receiving oral antidiabetic tablets. They were divided into groups on the basis of oral supplementation: (A) lysine, (B) essential amino acids, (C) amino acids and vitamins (fat and water-soluble), and (D) calcium phosphate (control). The subjects were periodically examined for fasting and post-prandial plasma glucose, fasting and post-prandial immunoreactive insulin, plasma amino acids, glycosylated haemoglobin (HbA1c), proteins and albumin in serium, urea and creatinine in plasma and sugar, and proteins and ketones in urine. Results: The results revealed a significant decrease in PP plasma glucose (P 0.05) in group B when compared to group s C and D after 45 days. Plasma Arginine was increased in group C from 3.84 to 9.24 mg/dl. There were no statistically significant changes seen in other parameters between groups and visits. Conclusions: Oral supplementation with amino acids for patients with type 2 DM appears to decrease PP plasma glucose without any change in plasma insulin levels, perhaps due to improved insulin sensitivity. However, the long term effects of amino acids need further study.


    1299/2523

    Tytuł oryginału: Clinical implications of acute mycoardial infarction complicated by high grade atrioventricular block.
    Autorzy: Ruiz-Bail‚n Manuel, Hoyos Eduardo Aguayo de, Issa-Khozouz Ziad, Diaz-Castellanos Miguel Angel, López-Martinez Asunción, Calatrava-López Jes—s, Barranco-Ruiz Mercedes, Ruiz-Ferrón Francisco, Muńoz-Beltran Humberto Jos‚
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR138-CR147, tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of this study was to assess the incidence, clinical course, prognosis and mean length of stay in acute myocardial infarction (AMI) complicated by high-grade atrioventricular block (HAVB). Material/Methods: A retrospective cohort study including all AMI patietns listed from january 1995 to September 2000 in the ARIAM multi-center register. Univariate analysis was carried out to study the factors associated with the development of HAVB, the mortality ratek, and the mean length of stay, and multivariate logistic regression analysis to study whether HAVB is an independent predictive variable for mortality or prolongation of stay. Results: Of the 14.181 AMI patients included int he register, 837 (5.9 p.c.) presented with HAVB, which was associated with age, female sex, increased severity, diabetes, inferior and Q-wave AMIs, and a higher peak creatine phosphokinase (CPK) level. The HAVB patietns developed more complications, required more diagnostic-therapeutic resources, and showed significantly higher mortality (p 0.0001) and increased mean length of stay (p 0.0001). The independent risk factors for HAVB were age, maximum peak CPK, inferior or combined localization of the AMI, Q-wave AMI, diabetes, a Killip and Kimbal score 1, and thrombolysis. HAVB was found to be an independent predictive vairable for mortality and increased mean length of stay. Conclusions: AMI patients with HAVB, despite thrombolytic treatment, are at risk for complications, amortality and longer mean admissions. Further study is needed on the outcome of a more active reperfusion policy, such as direct, rescue angioplasty etc.


    1300/2523

    Tytuł oryginału: Circulating oxidized LDL is associated with increased levels of cell-adhesion molecules in clinically healthy 58-year old men (AIR study).
    Autorzy: Hulthe Johannes, Fagerberg Bj”rn
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR148-CR152, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Inflammation has been postulated to play an important role in atherosclerosis development. Recently, research in this field has been focused on the role of modified lipoproteins, primarily oxidized low density lipoprotein. Adhesion and transendothelial migration of circulating leukocytes, by the action of cell-adhesion molecules, seem to be critical steps in early atherogenesis. Previous in vitro studies on the relationship between ox-LDL and the expression of celladhesion molecules on endothelial cells have shown diverging results. Furthermore, there are as yet no reports on the relationship between circulating ox-LDL and cell-adhesion molecules in vivo. Material/Methods: The relationship between circulating ox-LDL and adhesion molecules was measured by ELISA in clinically healthy, 58-year-old men recruited from the general population (n = 391). Results: The results of the present study showed that circulating ox-LDL was associated with sICAM-1 and sE-selectin, but not with sVCAM-1. After adjustment for other risk factors, i.e. systolic blood pressure, LDL cholesterol, apoB, apoA1 and smoking, the observed relationship between ox-LDL and sICAM-1 and sE-selectin, respectively, remained statistically significant. Conclusion: The observed results fir into the concept that oxidatively modified LDL may regulate the increased expression of cell-adhesion molecules on endothelial cells in vivo. These observations were made in a population-based sample of clinically healthy, middle-aged Caucasian men. Since this was a cross-sectional study no conclusions can be drawn on causality.


    1301/2523

    Tytuł oryginału: Long-term assessment of pulmonary function tests in pediatric survivors of acute respiratory distress syndrome.
    Autorzy: Abraham Ron Ben, Weinbroum Avi A., Roizin Hector, Efrati Ori, Augarten Arie, Harel Ran, Moreh Osnat, Barzilay Zohar, Paret Gideon
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR153-CR157, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: Background: The aim of the study was to evaluate long-term pulmonary function tests in pediatric survivors of acute respiratory distress syndrome (ARDS). Material/Methods: Observational study based on a telephone poll of retrospectively identified post ARDS children who were hospitalized in a pediatric intensive care unit (PICU) in a general 1200-bed teaching, tertiary, regional referral center for children. Results: Follow-up pulmonary function tests were achieved in only 7 children, with a man age of 7.3 ń 4.3 years (range 3-12) and following 5.6 ń 4.3 years after PICU discharge. The etiology for ARDS included: lymphoma (n = 2), pneumonia (n = 2), aspiration (n = 1), petrol ingestion (n - 1) and snake envenomation (n = 1) and snake envenomation (n = 1). The children had been ventilated for 9.4 ń 7.3 days and their worst PaO2/FiO2 ratio was 65.1 ń 17.0 mm Hg. The follow-up pulmonary functions in all the children was within normal limits except for one child who had mildly reduced DLco and one who had mild exercise-induced hypoxemia (oxyhemoglobin saturation of 94 p.c.). neither of the two nor the others showed subjective symptoms or clinical physical limitations. Conclusions: Children who survive ARDS apparently enjoy long-term normal pulmonary function. Some, however, amy present sublicnial dysfunction that persists for many years after the acute episode and evoked only by sophisticated lung tests.


    1302/2523

    Tytuł oryginału: Inflammatory bowel disease in Greece - a hospital-based clinical study of 172 consecutive patients.
    Autorzy: Archimandritis Athanasios J., Kourtesas Dimitris, Sougioultzis Stavros, Giontzis Apostolos, Grigoriadis Pantelis, Davaris Panagiotis, Tzivras Michalis
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR158-CR164, il., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: It has been suggested that inflammatory bowel disease (IBD) has a milder course in Greece than in other Western countries. THe purpose of our study was to assess the clinical icture of IBD in a hospital-based sample of IBD patients, followed from January 1986 to May 2001. Material/Methods: Retrospective study of 172 patients: 130 with UC followed up for 1-360 months (mean 66 ń 57 months) and 42 with CD for 1-240 months (mean: 51.85 ń 63.68 months). Results: 63 UC patients (48 p.c.) required hospitalization, 30 (23 p.c.) on the first attack; 72 (55 p.c.) had left sided colitis and 23 (18 p.c.) pancolitis; in 6 cases, (5 p.c.), surgical intervention was indicated at onset, 4 (3 p.c.) were operated. During FU, 15 patietns (11.5 p.c.) were operated, 4 (3 p.c.) as medical emergencies, 3 (2p.c.) due to colon cancer, the others for intractable colitis or long-standing disease; 5 patients ( 4 p.c.) developed toxic dilation of the colon, 3 (2 p.c.) developed colon cancer and 4 (4 p.c.) extraintestinal malignancies. 7 patients (5 p.c.) died; 2 (1.5 p.c.) due to the disease and the remainder for other causes. 19 CD patients (45 p.c.) had ileocolitis and 14 (33 p.c.) colitis; 22 (52 p.c.) needed hospitalization on the first attack. In 12 patietns (29 p.c.) surgical intervention was required on initial onset or during FU. One patient developed colon cancer (2 p.c.) Two men died (5 p.c.) from mycoardial infarction. Conclusion: IBD does not have a milder course in Greece than in other European populations.


    1303/2523

    Tytuł oryginału: When is total aortic arch replacement indicated in patients with acute aortic dissection?
    Autorzy: Urbanski Paul P.
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR165-CR168, tab., bibliogr. 10 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of this preliminary study was to evaluate the effectiveness of our surgical strategy for acute aortic dissection with special emphasis on curative resection of the dissected segments of the aorta. Material/Methods: Between January 1995 and April 1999, 29 patients underwent surgery for acute aortic dissection. in 16 patients (Group 1) the dissection was limited to the ascending aorta (8 patients - Group 1a) or involved the ascending aorta and the entire aortic arch (8 patients - Group 1b). Complete resection of all dissected aortic segments (ascending aorta or ascending aorta with complete aortic arch) was performed in these cases, extending to the healthy tissue border. 13 patients (Group 2) presented with dissection of the entire aorta). These patients underwent replacement of the proximal part only of the dissected aorta. Results: Early mortality (within 30 days) and the incidence of perioperative cerebrovascular events was 3.4 p.c. and 10.3 p.c. respectively. These events all occurred in Group 2. During the follow-up period of up to six years, there were no significant differences between the surviving patients in regards to long-term mortality and morbidity, although a persisting patent false lumen was observed in seven patients from Group 2. Conclusions: Extension of ascending aorta replacement to include the complete aortic arch can be accomplished in patients amenable to complete resection of the dissected aorta without increasing operative risk and with good mid-term results. We believe that total aortic arch replacement is indicated in these cases.


    1304/2523

    Tytuł oryginału: Assessment of the value of pHmetry results in diagnostics of gastroesphageal reflux as a cause of obstructive bronchitis in children.
    Autorzy: Zielińska Izabela, Czerwionka-Szaflarska Mieczysława
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR169-CR174, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The study assessed the incidence of pathologic gastroesophageal reflux in children with obstructive bronchitis and analyzed the correlation of pHmetric parameters with the incidence of obstructive bronchitis according to age groups. Material/Methods: 109 children aged from 4 months to 17 years with the history of at least two documented incidents of obstructive bronchitis during the period of one year were examined. Each patient underwent 24h esophageal pHmetry. The analyzed patients were divided into 3 age groups: I - 4 months-2 years, II - 3-9 years, III - 10-17 years; each of the obtained groups was divided into 2 subgroups according to the frequency of obstructive bronchitis (a - 2-4 times a year and b - over 4 times a year). Results: Gastroesophageal reflux was diagnsoed on the basis of pHmetry in 62.4 p.c. of patients. It was demonstrated in own material that gastroesophageal reflux is more frequent in boys (64.7 p.c.) than in girls (35.3 p.c.). Comparison of pHmetric parameters in children suffering from obstructive bronchitis more and less frequently did not demonstrate higher pHmetric parameters in children with more frequent occurrence of obstructive bronchitis in any of the age groups. Although gastroesophageal reflux occurred frequently in children with obstructive bronchitis, no proportional correlation was found between the pHmetric parameters and frequency of obstructive bronchitis. Conclusion: Esophageal pHmetry should be performed in children with obstructive bronchitis in order to confirm or exclude gastroesophageal reflux as a cause of recurrent obstructive bronchitis.


    1305/2523

    Tytuł oryginału: Role of fasting serum C-peptide as a predictor of cardiovascular risk associated with the metabolic X-syndrome.
    Autorzy: Haban Peter, Simoncic Robert, Zidekova Eva, Ozdin Lubomir
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR175-CR179, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Insulin resistance with increased insulin and C-peptide levels is the basis of the metabolic X-syndrome, so it is reasonable to expect them to be a good predictor of associated cardiovascular risk factors. Material/Methods: A total of 29 paitents (21 postmenopausal women and 8 men) with type 2 diabetes mellitus (mean duration 14.6 years, 95 p.c. CI 11.9 to 17.3 years), all older than 50, were studied for possible links between fasting serum C-peptide levels and other vascular risk factors. The mean value of the C-peptide in the group was 0.627 nmol/l (95 p.c. CI: 0.464 to 0.789 nmol/l). Results: We found statistically signifcant correlations between C-peptide and traicylglycerosl (TG; r - 0.474; p = 0.009), HDL-cholesterol (inverse; r = -0.567; p = 0.001) and various lipoprotein rations: atherogenic index (= total/DHL cholesterol: r = 0.599; p = 0.0006) or TG/HDL (r = 0.587; p = 0.0008). C-peptide also correlated with the body mass index (BMI: r = 0.519; p = 0.004) and leptin (r = 0.492; p = 0.007). After the coefficient CpG (C-epeptide x fasting glycemia) was introduced, the correlations with lipoproteins became even stronger. Conclusion: We suggest that elevated (fasting) serum C-peptide levels constitute a clinically important marker of the cardiovascular risks associated with the metabolic X-syndrome. It can be used as an effective tool for the early detection of diabetic patients at particular risk for atherosclerotic cardiovascular diseases and needing early preventive measures or aggressive treatment.


    1306/2523

    Tytuł oryginału: Further studies of genetic susceptibility to Graves' disease in a Russian population.
    Autorzy: Chistiakov Dimitry A., Savost'anov Kirill V., Turakulov Rustam I., Petunina Natal'ya, Balabolkin Mikhail I., Nosikov Valery V.
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR180-CR184, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Graves' disease (GD) is a polygenic autoimmune thyroid syndrome. Some of the genes implicated in its pathogenesis may encode thyroid-stimulating hormone receptor (TSHR) and estrogen receptors 1 (ESR1) and 2 (ESR2). We examined dinucleotide repeat polymorphisms in the ESR1 and ESR2 genes and D727E amino acid substitution in the TSHR gene for possible association with GD in a Russian population. Material/Methods: The polymorphic regions of the target genes were amplified by polymerase chain reaction (PCR) on the basis of genomic DNA isolated from blood of 78 unrelated Russian patients with GD and 93 control subjects. TO detect the D727E TSHR polymorphism, the PCR product was additionally digested with Eco721 restriction endonuclease. The genotype and allele frequencies in the groups studied were compared by chi-squared test. The odds ratios and 95 p.c. confidence intervals (CI) were calculated to assess the strength of the relationship between the polymorphisms tested and GD. Results: For polymorphic dinucleotide microsatellites at ESR1 and ESR2, no significant difference was observed in allele frequencies between affected and nonaffected patients. For the D727E TSHR polymorphism, the E allele and the DE genotype were significantly more frequent (p 0.0001) in patients with GD than in control subjects. Conclusions: The D727E variant of the TSHR gene is associated with Graves' disease in a Russian population. The E727 allele and the heterozygous D727E genotype are realated to higher risk of the disease. No association with GD was found for polymorphic microsatellites of the ESR1 and ESR2 gene.


    1307/2523

    Tytuł oryginału: Assessment of correlation between the presence of antiendomysial antibodies and small intestine mucosal villous atrophy in the diagnostics of celiac disease.
    Autorzy: Szaflarska-Szczepanik Anna
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR185-CR188, il., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to analyze the degree of correlation between the presence of serum antiendomysial antibodies and villous atrophy in small intestine mucosa in patients with celiac disease. Material/Methods: Retrospective analysis carried out in a group of 88 children and young adults (28 males, 60 females aged from 2 to 23) hospitalized in the Clinic from 1990 to the present with positive results of serum antiendomysial antibody test performed because of suspected celiac disease. The IgA - EmA test was performed after determination of whole IgA level in the serum using indirect immunofluorescence technique with monkey esophagus as an antigen. All patients underwent endoscopic small intestine biopsy with histopathological assessment of mucosal bioptates using standard hematoxylin and eosin staining. Results: The serum levle sof IGA in all investigated patietns were normal. The levels of antiendomysial antiboides expressed in IF units ranged from 10 to 40960. Histopathological assessment of small intestine mucosal bioptates revealed partial (in 13.6 p.c. of patients) or total (in 86.4 p.c. of patients) villous atrophy. Conclusion: The study demonstrated complete correlation between the presence of serum antiendomysial antibodies and villous atrophy in the small intestine mucosa.


    1308/2523

    Tytuł oryginału: Selected parameters of fibrinolysis system in patients with dermatitis herpetiformis.
    Autorzy: Wankiewicz Anna, Iwan-Ziętek Iza, Kotchy Maria, Gwieździński Zenon
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR189-CR192, tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dermatitis herpetiformis (DH) is a very rare bullous dermatitis of autoimmune origin. It is a sydnrome involving dermal and intestinal pathology, in which vesicopapular skin lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin bioptate (presence of granular IgA deposits in the upper portions of dermal papillae). Materia/Methods: The study was carried out in a group of 33 patients, including 23 males and 10 females aged 22-78 (mean age 44.7 years). The following fibrinolysis system parameters were determined in the sera of all patients: tissue plasminogen activator concentration (t-PA: Ag), urokinase plasminogen activator concentration (u-PA: Ag), plasminogen activator inhibitor concentration (PAI-Ag), plasminogen level, alpha-2 antiplasmin activity (ŕ-2-AP), plasmin - alpha-2 antiplasmin complexes concentration (PAP). Results: Mean t-PA concentration in DH patients was 5.52 ng/ml, vs.4.8 ng/ml in controls. The respective u-PA concentrations amounted to 0.33 ng/ml, and 0.39 ng/ml. PAI-1 concentration was markedly higher in DH patietns (36.2 ng/ml) than in controls (22.40 ng/ml), whereas plasminogen level was significantly lower (86.0 p.c. vs. 115.9 p.c.). In patients, ŕ-2-AP activity was 92 p.c. and was ower than in controls - 103.4 p.c. DH patients demosntrated also higher concentrations of PAP complexes (327.45 ng/ml) than the control group (203.03 ng/ml). Conclusions: Patietns with DH were found to have lower plasminogen and ŕ-2 antiplasmin levels and increased concentrations of PAP complexes, which indicates increased plasminogenesis n vivo. Increased type 1 plasminogen activator inhibitor level (PAI-1) may reflect a chronic inflammatory condition present in DH patients.


    1309/2523

    Tytuł oryginału: Credibility of problem-solving therapy and medication for the treatment of depression among primary care patients.
    Autorzy: Thornett Andrew M., Mynors-Wallis Laurence M.
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR193-CR196, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: Patient beliefs in the effectiveness of treatment may have an importan influence on treatment outcome. Material/Methods: Associations between patient beliefs in the credibility of treatment and outcome were explored in a randomised controlled trial of major depression in primary care (n = 155). The four treatments were antidepressant medication given by research general practitioner, problem solving treatment given by research general practitioner or research practice nurse over 12 weeks or a combination of problem solving treatment and antidepressant medication. Patietns' belief in the credibility of treatment was assessed using a brief Credibility Scale, that was completed following randomisation and after tretment. Depression outcome was measured at 6, 12 and 52 weeks using the Hamilton Rating Scale for depression, and the Beck depression inventory. Results: Pre-treatment, medication treatment was associated with a higher certainty of recovery than was problem-solving treatment from the nurse (p = 0.018). Post-treatment, medication and combination treatment were seen as more logical than problem-solving treatment from the nurse (p 0.03). Post-treatment medication had higher certainty of recovery and was more highly recommended to a friend. Linear regression demonstrated that the depression outcome measures were not associated with either pre- or post-treatment credibility. Conclusions: Patietns found all four treatments highly credible following their initial explanation. There was a significant difference both pre- and post-treatment in favour of patients finding treatment involving medication more credible than problem-solving from a nurse. Pre- and post-treatment scores of credibility were not associated with outcome.


    1310/2523

    Tytuł oryginału: Comparison of three instruments for assessing ongoing intimate partner violence.
    Autorzy: Ernst Amy A., Weiss Steve J., Cham Elaine, Marquez Martina
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR197-CR201, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Acitve injury surveillance programs need to address 'ongoing' intimate partner violence (IPV). While the Abuse Assessment Screen (AAS) has been validated for 'present' (within a year) IPV it is not clear that it is valid for 'present' (ongoing) IPV. We have created an OAS (Ongoing Abuse Screen, OAS) by changing the AAS to specifically request information related to 'ongoing' IPV. The hypothesis of this study was that the OAS represents a construct that is different from either the original AAS or a single question asking about ongoing IPV. Material/Methods: All patietns presenting to the ED during a convenience sampling of shifts completed the survey. The survey included the OAS, the AAS, and the question "Are you presently a victim of IPV?' Comparisons were made between these 3 using the kappa statistic for agreement. Results: A total of 488 surveys were completed. The AAS was positive in 288/488 (59 p.c., 95 p.c. CI = 55-63 p.c.), the OAS was positive in 78/488 (16 p.c., 95 p.c. CI = 13-19 p.c.), and the single question for DV was positive in 14/488 (3 p.c., 95 p.c. CI - 2-5 p.c.). Kappa was 0.28 for the AAS and the OAS. When compared to the single question about present DV, kappa was 0.05 for the AAS and 0.27 for the OAS. Conclusion: The OAS may be a useful tool for evaluating ongoing IPV. The OAS resulted in rates different from that of the AAS and may be more specific to ongoing IPV than the AAS and more sensitive than a single question about DV.


    1311/2523

    Tytuł oryginału: Effect of erythropoietin therapy and selenium supplementation on selected antioxidant parameters in blood of uremic patients on long-term hemodialysis.
    Autorzy: Adamowicz Andrzej, Trafikowska Urszula, Trafikowska Anna, Zachara Bronisław A., Manitius Jacek
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR202-CR205, tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The kidney accumulates the highest level of selenium (Se) in the organism and is the major source of plasma glutathione peroxidase (GSH-Px). Se, as an integral part of the active site of GSH-Px, plays an important role in protecting cell membranes from oxidative damage. Decreased blood Se levels and GSH-Px activity are common in chronic renal failure (CRF) patietns. Our study was an effort to evaluate the effect of erythropoietin (EPO) therapy and Se supplementation for CRF patients undergoing regular hemodialysis (HD) on blood Se, red cell glutathione (GSH), and blood lipid peroxidation product levels, and on blood activity levels of GSH-Px and blood superoxide dismutase (SOD). Material/Methods: Our subjects were divided into three groups: I - CRF patietns on regluar HD and EPO,II-HD patietns receiving EPo and Se, and III - healthy controls. Se levels, SOD and GSH-Px activities were measured spectrofluorometrically, the GSH level by Beutler's colorimetric methods, and lipid peroxidation products using TBARS. Results: EPO therapy with Se supplementation significantly increased whole blood and plasma Se in HD patients, and raised red cell GSH-Px activity, but plasa GSH-Px acitivity, plasma superoxide dismutase, and plasma and red cell TBARS did not respond to Se supplementation. EPO alone showed no effect on these parameters. Conclusions: Treatment with EPO and supplementation with Se significantly increased the element concentration in whole blood and plasma, and GSH-Px activity in red cells. Plasma GSH-Px activity did not resond to Se.


    1312/2523

    Tytuł oryginału: Leptin and estradiol as related to change in pubertal status and body weight.
    Autorzy: Larmore Kimberly A., O'Connor Darlise, Sherman Tami Irwin, Funanage Vicky L., Hassink Sandra G., Klein Karen Oerter
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR206-CR210, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Background: Previous studies have examined the relationship between leptin, body mass, and pubertal status. The present study directly compares the relationship of leptin and estradiol in 5 groups of girls with different combnations of pubertal status and weight. Material/Methods: We studied girls with idiopathic precocious puberty, age-matched non-obese prepubertal girls, age-matched obsese prepubertal girls, normal pubertal girls, and obese pubertal girls (n = 12/group). Results: Leptin levels were significantly higher in obese pubertal girls (26.6 ń 8.4 ng/mL) than in all others. Leptin levels were signifcantly higher in obese prepubertal girls (20.7 ń 10.9 ng/mL) (mean ń SD) compared to girls with precocious puberty (7.7 5.4 ng/mL, p 0.004), non-obese prepubertal girls (5.55 ń 3.6 ng/mL, p 0.001), and normal pubertal girls (4.8 ń 2.9 ng/mL, dard deviation score), which corrects leptin level for gender, pubertal stage, and BMI, was significantly lower in the obese pubertal group than in the 3 non-obese groups. Conclusions: These findings confirm previous studies that body mass, chronolgoical age and pubertal stage are determinants of leptin level. However, these are not the only factors determining leptin level as evidenced by persistent differences in leptin level between obese and non-obese pubertal girls even when correcting for pubertal stage and BMI. While the present study provides no new answers to the question of pubertal regulation, it provides a direct comparison of combination weight, pubertal stage, and leptin level, as background for future studies.


    1313/2523

    Tytuł oryginału: Evaluation of oxidative stress indices during treatment in pregnant women with Intrauterine Growth Retardation.
    Autorzy: Karowicz-Bilińska Agata, Suzin Jacek, Sieroszewski Piotr
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR211-CR216, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Background: We investigated treatment-related changes in oxidative stress indices in intrauterine growth retardation (IUGR) during pregnancy. Four parameters of cell memebrane destruction were measured: malondialdehyde, Schiff bases, lipid peroxides, and conjugated dienes. Material/Methods: The study population included pregnant women under treatment in the Department of Obstetrics and Gynecology at the Medical University of Łódź in 1997-1999, divided into two groups: (I) - 30 healthy pregnant women, (II) - 31 pregnant women with a clinical and ultrasound diagnosis of IUGR. The course of treatment consisted of ten days of intravenous injections of cocarboxylase, Vitamin C, and solcoseryl as antioxidant factors. The parameters of oxidative stress were measured on the first day of hospitalization, after five days of treatment, and on the 10th day of treatment. Results: The mean value of MDA concentration in Group I was 2.03, vs. 2.39 in Group II. The mean value of conjugated dienes was 2.40 in Group I and 2.41 in Group II. The Schiff bases concentration in Group I was 8.03, as opposed to 8.83 in Group II. The concentration of lipid peroxides was 0.113 in Group I and 0.134 in Group II. We found that all the parameters of oxidative stress were higher in IUGR than in normal pregnancy. At the end of treatment a decrease was observed in all oxidative stress parameters. Conclusions: IUGR is correlated with an increase in membrane damage parameters. Therapy for IUGR decreased the values of all indices of oxidative stress.


    1314/2523

    Tytuł oryginału: Determination of lactic acid level in systemic liquids in children with progressive encephalopathies.
    Autorzy: Marszał Elżbieta, Wojaczyńska-Stanek Katarzyna, Pietruszewski Jerzy, Emich-Widera Ewa, Bielińska-Bujniewicz Eugenia
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR217-CR222, tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: This article reports the results of research into the activities of lactic acid concentrations in the body fluids of children with non-progressive encephalopathies (PE) in comparison to patients with non-progressive encephalopathies (NPE) and those with non-progressive encephalopathies with concomitant epilepsy (NPEE). The study was designed to determine whether there is difference between the serum and CSF lactic acid concentrations in children with progressive encephalopathies (PE), static (non-progressive) encephalopathies (NPE) and non progressive encephalopathies with concomitant epilepsy (NPEE), and whether the clinical status correlates with the concentration of these biochemical markers in children with PE. Material/Methods: The assessment involved 138 children of both sexes, whose age ranged between 8 months and 15 years, diagnosed and treated in the Neurology Department at the Pediatric Clinica of the Silesian Medical Academy in Katowice between 1995 and 1997. Lactate concentrations were determined in serum and cerebro-spinal fluid and analyzed statistically. Results: The findings showed higher serum and CSF concentrations in children with PE than in patietns who manifested non-progressive forms of encephalopathy. The degree of clinical symptom aggravation in PE children was likewise analyzed an compared to the values of lactate concentrations in body fluids; however, no correlation was found between these parameters. Conclusion: Children with progressive encephalopathies present higher lactate concentrations in serum and cerebrospinal fluid than patients with static (non-progressive) encephalopathy.


    1315/2523

    Tytuł oryginału: Patient acceptance and reliability of new Humulin/Humalog 3.0 ml prefilled insulin pen in ten Croatian diabetes centres.
    Autorzy: Sucic Mate, Galic Eduard, Cabrijan Tomislav, Ivandic Ante, Petrusic Ante, Wyatt John, Mincheva Nadia, Milicevic Zvonko, Malone James
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.PI21-PI26, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The objective of this study was to assess feature preferences, patietn accpetance, reliability, and safety of the new Lilly Humulinr/HumalogR 3.0 ml prefilled insulin pen in a clinical setting. Material/Methods: A total of 330 patients in Croatia with type 1 or type 2 diabetes mellitus who required at least one injection of insulin per day were treated with Humulin 30/70 or Humalog for 4 to 6 weeks using the new prefilled pen. Questionnaires concerning various aspects of the pen performance were administered at endpoint. Results: The features of the Lilly 3.0 ml pen device ranked most highly by patients (p.c. of excellent or good ratings) were cartridge visibility (93 p.c.), attaching/replacing needles (93 p.c.), ease of dose correction (92 p.c.), checking insulin flow (90 p.c.) and dialling of insulin dose (89 p.c.). Features of the pen device rated most highly by patients in comparison with the delivery systems used before the study and the percentage of patients rating those features as much better or better were ease of dose correction (74 p.c.), cartridge visibility (67 p.c.), autdible dialing clicks (55 p.c.) and size of dose numbers (52 p.c.). Most respondents (78 p.c.) preferred single-unit versus two-unit dosage increments. The majority of patients rated the new prefilled pen as being more convenient and easier to use, and indicated that it represented a significant or modest an improvement over their previous insulin injection method. Conclusio: The results of this study indicate that the new Lilly 3.0 ml prefilled pen is acceptable for patients who were previously using either reusable devices or the traditional syringe and vial.


    1316/2523

    Tytuł oryginału: Eradication of Helicobacter pylori in duodenal ulcer disease Tetracycline & Furazolidone vs. Metronidazole & Amoxicillin in Omeprazole based triple therapy.
    Autorzy: Mansour-Ghanaei Fariborz, Fallah Mohammad S., Shafaghi Afshin
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.PI27-PI30, tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The object of the study was to study the efficacy and safety of furazolidone and tetracycline compared to metronidazole an damoxicillin in an omeprazole based triple therapy in a prospective randomized-blind-clinical trial. Material/Methods: Patients with endoscopicaly verified active duodenal ulcer disease in the presence of Helicobacter pylori infection were eligible to enter the study. Endoscopy was performed a day before and 6-8 weeks after the cessation of treatment. H. pylori status was assessed by histologic examination (Giemsa stain) of biopsy specimens were taken from the antrum and corpus. H. pylori eradication was defined as absence in histology of the biopsy specimens at the second endoscopy. Ulcer healing was considered as decrease in ulcer size to less than 20 p.c. of its primary sieze. Patients were randomly assigned to receive omeprazole 20 mg, amoxicillin 1000 mg and metronidazole 500 mg (OAM group) or omeprazole 20 mg, tetracycline 500 mg and furazolidone 200 mg (OTF group). All medications were taken twice daily, for 2 weeks. Results: Out of 111 patients enrolled in the study, 108 completed a course of treatment and underwent a follow-up endoscopy, with 54 patients in each group. H. pylori eradication was achieved in 52 patients (96.3 p.c. - 95 p.c. CI: 91.27 - 100) in OTF gorup and 45 patietns (83.3 p.c. - 95 p.c. CI: 73.35 - 93.25) in OAM group (P = 0.015). Our study showed the superiority of OTF vs. OAM regimen with a 13 p.c. increment in eradication rate, with only occasional severe side effect. Conclusions: In conclusion OTF regiment is a safe, cheaper and effective alternative for OTF regimen and we recommend it to be used especially in developing countries.


    1317/2523

    Tytuł oryginału: Radioguided parathyroidectomy for reexploration of primary hyperparathyroidism - a case report.
    Autorzy: Kitagawa Wataru, Shimizu Kazuo, Akasu Haruki, Yamada Tetsu, Asayama Isao, Tanaka Shigeo
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CS21-CS25, il., bibliogr. 10 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: We reprot a case of radioguided parathyroidectomy using a hadn-held gamma probe for the reexploration of primary hyperparathyroidism. Case report: The patient was a 66-year-old Japanese woman. She had previously undergone surgical exploration for primary hyperparathyroidism due to a left inferior parathyroid tumor detected by 99mTc-methoxyisobutylisonitrile (MIBI) scintigraphy. However, the pathological diagnosis of the resected tumor was adenomatous goiter. 99mTc-MIBi scintirgraphy was performed again and revealed an abnormal uptake close to the right lower lobe of the tyroid. However, venous sampling for PTH measurements did not support this finding. Sestamibi was injected and the radioactivity was measured pre- and intraoperatively with a hand-held gamma probe. With the patient under general anesthesia, the tumor, which was adjacent to the right recurrent laryngeal nerve, was resected, but it contained only a low level of radioactivity ex vivo, indicating that it was not a parathyroid tumor. A hand-held gamma probe accurately located the radioactive parathyroid tumor in the right lower neck. The resected tumor measured 15x6 mm and weighed 331 mg. The pathological diagnosis was parathyroid adenoma. Conclusions: Radioguided parathyroidectomy is useful to localize parathyroid tumors not only in primary hyperparathyroidism at the initial neck exploration but also for reexploration.


    1318/2523

    Tytuł oryginału: Cat-scratch disease in an immunocompromised host.
    Autorzy: Harsch Igor Alexander, Schahin Simin Pour, Schmelzer Alexander, Hahn Eckhart Georg, Konturek Peter Christopher
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CS26-CS29, il., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Themain causative agents of cat-scratch disease are Bartonella henselae, tiny, gram-negative bacilli. The disease usually has a benign course with the development of a papule at the inoculation site, followed by regional lymphadenopathy. In most cases, complete resolution occurs, but in immunocompromised hosts, the course of the disease can be aggravated. Case report: A patietn recieved methotrexate and corticosteroids for 3 months due to rheumatoid arthritis. He developed fever, exanthema and leukopenia under methotrexate therapy. Dark red indurations with central ulcerations at his right thigh revealed a further problem apart from the methotrexate-induced leucopenia and immunosuppression. The ulcerations were the remainders of recurrent scratches from the patient's cat. The patient's antibody titers against Bartonella henselae remained low and inguinal lymph node swelling was only for a short time to be observed, this reaction obviously weakened as a result of the immunosuppression. However, the typical course, the exclusion of other reasons for the exanthema and the rapid improvement of the patient's condition after antibiotic treatment ascertained the diagnosis. Conclusions: In immunocompromised hosts, diseases with a typically benign course can become severe and life-threatening illnesses. Ownership of pets should be taken into consideration before onset of an immunosuppressive therapy.


    1319/2523

    Tytuł oryginału: Designing the optimal Total Cavopulmonary Connection: pulsatile versus steady flow experiments.
    Autorzy: DeGroff Curt G., Shandas Robin
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.MT41-MT45, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Background: The Total Cavopulmonary Connection (TCPC), used for repair of patients with single ventricle physiology, creates a passive system of blood flow into the pulmonary circulation where enhanced energy efficency may lead to improved long term patient outcomes. Previous numerical and in vitro studies using steady flow have shown that incorporation of SVC (superior vena cava) and IVC (inferior vena cava) offsets lead to decreased energy losses. We hypothesize that the optimal TCPC offset design found in these previous steady flow experiments may not be the optimal design in pulsatile flow situations. Material/Methods: 3-D finite volume numerical models were used to simulate flow through the total cavopulmonary connection. We ran steady and pulsatile flow experiments through 4 TCPC designs each with different SVC to IVC offsets (0.1/4, 1/2, 1 diameter offsets). The total energy (power) loss for each TCPC model was calculated. Results: In steady flow experiments, p.c. difference in energy loss between the most optimal and least optimal design was 26 p.c. In contrast, in pulsatile flow experiments the p.c. difference was only 8 p.c. Conclusion: Our results demonstrate the improvements in energy loss seen using SVC-IVC offsets in steady flow experiments do not necessarily translate to pulsatile flow situations. Overall there was lower differences in efficiency between all TCPC designs in the pulsatile flow experiments. These results emphasize the need for further studies to fully define the relationship between energy losses and TCPC vessel architecture innon-steady flow physiologic situations.


    1320/2523

    Tytuł oryginału: Fractal dimensions of human brain cortex vessels during the fetal period.
    Autorzy: Kędzia Alicja, Rybaczuk Marek, Andrzejak Ryszard
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.MT46-MT51, il., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Background: Fractal dimensions always involve some averaging with respect to the given geometrical object. The classical geometrical description includes overly detailed geometrical information, rendering the precise formulation of equations ineffective. The problems associated with the functionality and growth of biological systems according to their observed geometrical shape reguire a specific approach. Material/Methods: The material consists of 50 brains, 4th to 8th month of fetal life, length C.-R. 83-220 mm. The material was examined using the Pickworth method, computer image analysis (Imtronic, Scion for Windows 1998, and Elf v. 4.2), and fractal analysis. Various transformations were applied: numeric filters, statistical filters, binary geometrical transormations, arithmetical operations. Fractal analysis employs the 'box-counting' fractal dimension. Results: The cortex vein net maintains the fetal character, with a large number of anastomoses, also present in adults. The size of cortex branches amounts to 100-200 ćm. The reduction of some of the anastomoses during the early stages of evolution comes from an increase in the vessels' caliber. During the 4th month, the fractal dimension is 1.26, increasing to 1.53 at month 5. Rapid growth of the fractal dimension has been observed until the 6th and 7th months. This means an increased complexity level and feed volume in the brain. Conclusions: Fractals constitute a promising and effective tool to estimate the structures of brain vessels. The fractal dimension varies during the fetal period. This shows the close correspondence between the structure and functionality.


    1321/2523

    Tytuł oryginału: Liver regeneration: the emergence of new pathways.
    Autorzy: Zimmermann Arthur
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.RA53-RA63, bibliogr. 106 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: The present overview summarizes important knowledge having accumulated during the last years. The liver maintains a steady mass which is basically controlled by a delicate balance between cell gain and cell loss. However, reconstitution of the organ after tissue loss does not only involve replacement of target cells, but also complex remodeling processes resulting in the reconstruction of the typical tissual architecture. Most information in liver regeneration refers to hepatocytes. It is important to note that hepatocytes are not terminally differentiated cells, but cells situated in the G0 phase that can undergo proliferation upon appropriate stimulation. In most situations, hepatic stem cells are not significantly involved in this response. Hepatocyte regenration is accomplished by a sequence of distinct phases: an initiation phase, rendering cells in a state of replicative competence; a proliferation phase, where expansion of the cell population occurs; and a termination phase, where cell growth is suppressed to terminate regeneration at a set point. These three phases are regulated by a whole group of factors, mainly cytokines, the significance of which has in part been defined by use of animal models with target gene deletions (gene knockouts). It seems that several mechanisms are capable to snese the critical cell mass which has to be achieved. Hepatocyte regeneration is accompanied by a complex remodeling of hepatic tissue, with a transient breakdown of the lobular architecture. In contrast to hepatocytes, less is known for the regenerative replacement of bile ducts, blood vessels and hepatic stellate cells.


    1322/2523

    Tytuł oryginału: Asthma and gastroesophageal reflux in children.
    Autorzy: Wąsowska-Królikowska Krystyna, Toporowska-Kowalska Ewa, Krogulska Aneta
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.RA64-RA71, bibliogr. 45 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Gastroesophageal reflux (GER) is a factor often neglected in the etiopathoegensis of asthma. The estimated incidence of GER in asthmatic children reaches 50-60 p.c. and is higher than in the general population. GER may accompany typical symtoms: hoarsness, sore throat, thoracic pain, cough or wheezing. GER may not only aggravate the course of bronchial obstruction, but may aslo cause it, or trigger obstruction due to other factors. Asthma and GER coincidence has been acknowledged for many years. The paper presents a current review of studies concerning the relations between asthma and GER and attempts to establish, which is the cause and which is the result. The hypotheses how GER can lead to bronchial obstruction, and how obstruction can aggravate GER, are also presented. GER is believed to be a factor causing obstruction by : 1. an indirect mechanism - reflex theory, 2. a direct mechanism - reflux theory, and 3. a neuropeptide-mediated mechanims. The paper also presents diagnostic methods allowing to detect GER in asthmatics. A reveiw of recent studies concerning the treatment of GER in asthmatics, both with pharmacolgical and surgical methods, is also included. Beneficial effect of antireflux therapy on the course of asthma has been emphasied. Therefore, antireflux therapy is recommended in all patients with concurrent asthma and GER, irrespective of severity of clinical GER symptoms, even in those with silent GER. The essential drugs used in the treatmet of GER are proton pump inhibitors. Appropriately high dose level and appropriatelylong duration of the therapy should be taken into consideration.


    1323/2523

    Tytuł oryginału: The artificial heart - past, present, and future.
    Autorzy: Zareba Karolina M.
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.RA72-RA77, il., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Patients with advanced congestive heart failure have a very high 5-year mortality despite medical treatment. In such patients, heart transplantation is the treatment of choice. The number of patietns awaiting tansplantation is several-fold higher than the number of procedures performed. Heart transplantation therapy has numerous limitations and is assocaited with serious complications. The left ventricular assist device is a step towards this goal. It can be attached to the weakened left ventricle to temporarily increase blood flow to the body. The use of left ventricular assist devices helps the failing heart to recover and extends the duration over which a patient's heart can wait for a replacement donor heart. This therapy is in use for only up to a few months. The total artificial heart, Jarvik-7, first implanted in 1982, did not succeed due to a poor quality of a patient's life and numerous complications leading to death. Recently, a successful implantation of the AbioCor (Abiomed), the first fully implantable replacement heart, was accomplished. The AbioCor's internal battery system eliminates the need for the patient to bepermanently immobilized through tubes or wires connected to an external power source. Innovative transcutaneous energy transmission permits the recharging of itnernal batteries. The total artificial heart will require adapting it to different human body sizes as well as further improving its technical features. The total artificial heart is a remedy of the future coming to fruition right now, giving a chance to numerous heart failure patients by extending and improving their lives.


    1324/2523

    Tytuł oryginału: Retention and selectivity of liquid-solid chromatographic systems for the analysis of pesticides (Retention Database)
    Autorzy: Tuzimski Tomasz, Soczewiński Edward; Medical University Pharmaceutical Faculty, Department of Inorganic and Analytical Chemistry in Lublin
    Źródło: - Lublin, MU 2002, 219, [5] s. : il., tab., bibliogr. 111 poz., 24 cm.
    Seria: Problemy Nauki, Dydaktyki i Lecznictwa 12
    Sygnatura GBL: 735,794

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny


    1325/2523

    Tytuł oryginału: Course Book : The European Federation of National Association of Orthopaedics and Traumatology and Polish Society of Orthopaedics and Traumatology
    Źródło: - Kraków, EFORT 2002, 154, [2] s., 24 cm. - 9 Konferencja Szkoleniowa EFORT Europejskiej Federacji Narodowych Stowarzyszeń Ortopedycznych i Traumatologicznych Kraków 24-26.10. 2002
    Sygnatura GBL: 735,796

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    1326/2523

    Tytuł oryginału: Annual Report 2001
    Polish Academy of Sciences Medical Research Centre
    Źródło: - Warszawa, PAS MRC 2002, 155 s., 21 cm.
    Sygnatura GBL: 735,811

    Typ dokumentu:
  • sprawozdanie
  • informator
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Polska Akademia Nauk


    1327/2523

    Tytuł oryginału: Gene therapy for hypertension: future or fiction?
    Tytuł polski: Terapia genowa nadciśnienia tętniczego: przyszłość czy fikcja?
    Autorzy: Fennell Jerome P., Brosnan M. Julia, Frater Arlene J., Baker Andrew H., Dominiczak Anna F.
    Źródło: Nadciśn. Tętn. 2002: [6] supl. A: Sympozjum naukowe "Aspekty genetyczne nadciśnienia tętniczego" s.A3-A10, il., tab., bibliogr. 45 poz., streszcz. - Sympozjum naukowe pt. Aspekty genetyczne nadciśnienia tętniczego Warszawa 23.11. 2001
    Sygnatura GBL: 313,470

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie polskie: Niniejszy artykuł to przegląd aktualnych badań poświęconych wykorzystaniu transferu genów kodujących substancje wpływające na naczynia krwionośne w terapii nadciśnienia tętniczego. Dwa główne kierunki badań obejmują zwiększanie działania naczyniorozkurczowego poprzez transfer genów kodujących substancje rozkurczające naczynia lub transfer cząsteczek antysensowych w celu zahamowania ekspresji substancji powodujących skurcz naczyń. W różnych badaniach z użyciem modeli zwierzęcych wykazano skuteczność transferu genów dla kallikreiny, adrenomedulliny, przedsionkowego peptydu natriuretycznego i syntazy tlenku azotu w obniżaniu ciśnienia tętniczego. Metody te wymagają jednak dalszego opracowywania ze względu na potrzebę usprawnienia procedury podawania genu oraz konieczność oceny skutków ubocznych. Wykorzystanie antysensowych oligonukleotydów do zahamowania działania układu renina-angiotensyna okazało się także skuteczne podczas badań na modelach zwierzęcych. Używano różnych metod wprowadzania cząsteczek - liposomów, retrowirusów i plazmidów osiągając różny czas trwania efektu hipotensyjnego. Terapia genowa dostarcza fascynujących możliwości leczenia, jednak konieczność zoptymalizowania używanych wektorów, znalezienia docelowych genów i oceny możliwych efektów ubocznych i długoterminowych wymaga jeszcze wiele wysiłku i czasu.


    1328/2523

    Tytuł oryginału: Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia.
    Autorzy: Gluckman Eliane, Rokicka-Milewska Ritta [Roma], Hann Ian, Nikiforakis Emmanouel, Tavakoli Filipos, Cohen-Scali Sophie, Bacigalupo Andrea
    Źródło: Br. J. Haematol. 2002: 119 (4) s.1075-1082, il., tab., bibliogr. s. 1081-1082
    Sygnatura GBL: 303,964

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In patients with idiopathic severe aplastic anaemia who are treated with immunosuppressive agents to combat T lymphocyte-mediated destruction of haematopoietic progenitor cells, neutropenia is a major cause of infections and toxicity. Evidence from preliminary studies suggests that recombinant human glycosylated granulocyte colony-stimulating factor (lenograstim) increases the number and functionality of neutrophils in patients with severe aplastic anaemia. This randomized, parallel-group, multicentre study was conducted to evaluate the efficacy and safety of subcutaneous lenograstim during the first 12 weeks of standard immunosuppressive therapy in 102 patients with de novo severe aplastic anaemia. The addition of lenograstim to standard therapy resulted in an increase in the proportion of patients showing complete neutrophil response (83ú0 p.c. vs 44ú9 p.c.; P 0ú0001). This was seen even among patients with very severe aplastic anaemia (69ú2 p.c. vs 31ú6 p.c.; P = 0ú012). In patietns receiving lonograstim, median time to complete neutrophil response was shorter (6ú3 vs 16ú1 weeks; P = 0ú0001) and mean duration of first neutrophil response was longer (P = 0ú0248) than in the control group. At a median follow-up of 5 years, no difference was observed between the grous in term of survival, haematological response and occurrence of secondary leukaemia (one patient in each group). We conclude that lenograstim support of immunosuppressive therapy might be used for patients with severe aplastic anaemia as it significantly enhances neutrophil recovery but does not modify the overall response and survival.


    1329/2523

    Tytuł oryginału: Lyn and syk kinases are sequentially engaged in phagocytosis mediated by FcçR.
    Autorzy: Strzelecka-Kiliszek Agnieszka, Kwiatkowska Katarzyna, Sobota Andrzej
    Źródło: J. Immunol. 2002: 169 (12) s.6787-6794, il., tab., bibliogr. 44 poz.
    Sygnatura GBL: 300,982

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Recent data indicate that phagocytosis mediated by FcçRs is controlled by the Src and Syk families of protein tyrosine kinases. In this study, we demosntrate a sequential involvement of Lyn and Syk in the phagocytosis of IgG-coated particles. The particles isolated at the stage of their binding to FcçRs (4řC) were accompanied by high amounts of Lyn, in addition to the signaling ç-chain of FcçRs. Simultaneously, the particle binding induced rapid tyrosine phosphorylation of numerous proteins. During synchronized internalization of the particle induced by shifting the cell to 37řC, Syk kinase ans Src homology 2-containing tyrosine phosphatase-1 (SHP-1) were associated with the formed phagosomes. At this tep, most of the proteins were dephosphorylated, although some underwent further tyrosine phosphorylation. Quantitative immunoelectron microscopy studies confirmed that Lyn accumulated under the plasma membrane beneath the bound particles. High amounts of the ç-chain and tyrosine-phosphorylated proteins were also observed under the bound particles. When the particles ere internalized, the ç-chain was still detected in the region of the phagosomes, while amounts of Lyn were markedly reduced. In contrast, the vicinity of the phagosomes was heavily decorated with anti-Syk and anti-SHP-1 Abs. The local level of protein tyrosine phosphorylation was reduced. THe data indicate that the accumulation of Lyn during the binding of IgG-coated particles to FcçRs correlated with strong tyrosine phosphorylation of numerous proteins, suggesting an initiating role for Lyn in protein phosphorylation at the onset of the phagocytosis. Syk kinase and SHP-1 phosphatase are mainly engaged at the stage of particle internalization.


    1330/2523

    Tytuł oryginału: Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers.
    Autorzy: Naruszewicz Marek, Johansson Marie-Louise, Zapolska-Downar Danuta, Bukowska Hanna
    Źródło: Am. J. Clin. Nutr. 2002: 76 (6) s.1249-1255, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 311,679

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The short-chain fatty acids formed in the human colon by the bacterial fermentation of fiber may have an antiinflammatory effect, may reduce insulin production, and may improve lipid metabolism. We previously showed in hypercholesterolemic patietns that supplementation with the probiotic bacteria Lactobacillus plantarum 299v significantly lowers concentrations of LDL cholesterol and fibrinogen. Objective: We determined the influence of a functional food product containing L. plantarum 299v on lipid profiles, inflammatory markers, and monocyte function in heavy smokers. Design: Thrity-six healthy volunteers (18 women and 18 men) aged 35-45 y participated in a controlled, randomized, doubleblind trial. The experimental group drank 400 mL/d of a rose-hip drink containing L. plantarum 299v (5 x 10**7 colon-forming units/mL); the control group consumed the same volume of product without bacteria. The experiment lasted 6 wk and entailed no changes in lifestyle. Results: Significant decreases in systolic blood pressure (p 0.0001), leptin (P 0.000), and fibinogen (P 0.001) were recorded in the experimental group. No such changes were observed in the control group. Decreases in F2-isoprostanes (37 p.c.) and interleukin 6 (42 p.c.) were also noted in the experimental group in comparison with baseline. Monocytes isolated from subjects treated with L. plantarum showed significantly reduced adhesion (P 0.001) to native and stimulated human umbilical vein endothelial cells. Conclusion: L. plantarum administration leads to a reduction in cardiovascular disease risk factors and could be useful as a protectvie agent in the primary prevention of atherosclerosis in smokers.


    1331/2523

    Tytuł oryginału: Evidence for the hydrolysis of topical applied liposomal lipids in human stratum corneum.
    Autorzy: Zellmer Sebastian
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (3) s.885-888, il., bibliogr. 9 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Liposomes were incubated with an extract of human plantar stratum corneum. The liposomal lipids were hydrolysed, if composed of soy-bean phosphatidylcholine or phosphatidylgycerol. Rigid lipids were not degraded. The temperature optimum of the hydrolysis was between 30-35řC. CaCl2 enhanced, while EDTA reduced the rate of hydrolysis, indicating that the hydrolysis is due to a phospholipase A2.


    1332/2523

    Tytuł oryginału: The role lipid phase structure in the interaction of lactate dehydrogenase with phosphatidylserine. Activity studies.
    Autorzy: Terlecki Grzegorz, Czapińska Elżbieta, Gutowicz Jan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (3) s.895-903, il., bibliogr. 27 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Lactate dehydrogenase is one of the enzymes of the glycolytic path. It has been shown to be able to bind in vitro to cellular membranes. The presence of anionic phospholipids induces changes in the catalytic properties of the enzyme similar to those found when the enzyme is bound to natural membranes. In this study, a nonionic detergent (Tween 20), at concentrations not affecting the catalytic activity of LDL, was used to study the role of the lipid supra-molecular structure in the interaction between pig skeletal muscle lactate dehydrogenase and phosphatidylserine. Tween 20 changes the equilibrium of concentrations between the lipid supra-molecular forms. The detergent at ther used concentration values did not alter the activity of the enzyme when it was used on its own, but did diminsh the level of inhibition induced by the studied phospholipid. The obtained results showed that the interaction is reversible and that the bilayer structure of the lipid is essential for the inhibition.


    1333/2523

    Tytuł oryginału: Further evidence for the importance of lipid bilayers in the interaction between lactate dehydrogenase and phosphatidylserine.
    Autorzy: Terlecki Grzegorz, Gutowicz Jan
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (3) s.905-910, il., bibliogr. 14 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Lactate dehydrogenase (LDH) is one of the glycolytic enzymes, which have been proved to have the capibility to reverse non-specific adsorption on cellular membranous structures in vitro, as well as on the structural proteins of the contractile system of muscle cells. It has been suggested that this binding may play a physiological role, as it alters the enzyme's kinetic properties. Our previous studies on this enzyme showed that its interaction with some anionic phospholipids reveals similar characteristics and similar effect on the activity of the enzyme to those ehich had been observed for the interaction with membranous structures. Disruption of the lipid bilayers by nonionic detergent (Tween 20) restored the enzyme activity inhibited by the presence of phosphatidylserine (PS) liposomes. In this study, we used the measurement of enzyme tryptophanyl fluorescence spectra to monitor the interaction andf possible changes in the enzyme conformation. The investigation provided further evidence of the importance of the bilayer structure in this interaction. Similarly to the effect on the activity of the enzyme, the addition of Tween 20 diminishes the quenching of the LDH tryptophanyl fluorescence, and finally completely restores the fluorescence.


    1334/2523

    Tytuł oryginału: Lipid-based antifungal agents: a concise overiew.
    Autorzy: Arikan Sevtap
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (3) s.919-922, bibliogr. 5 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The development of lipid formulations of antifunagal drugs has been a remarkable progress in the systemic antifungal arena. The lipid-based amphotericin B formulations; amphotericin B lipid complex (ABLC), amphotericin B colloidal dispersion (ABCD), and liposomal amphotericin B (L-AMB) have been in clinical use since 1990s. They are significantly less nephrotoxic than the parent compound and can be safety used at higher doses. The primary cost of these formulations is significantly high and the extent of data related to their head-to-head comparison remains limited. The lipid formulation of nystatin, liposomal nystatin, is another lipid-based polyene under development. Available data concerning the in vitro activity, pharmacokinetic profile, in vivo efficacy, and safety of these formulations are summarized in this overview.


    1335/2523

    Tytuł oryginału: VIII Polish Conference on Cell Biology - erratum and late abstracts.
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (3) s.939-944 - 8 Polska Konferencja nt. biologii komórki Wrocław 23-25.09. 2002
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    1336/2523

    Tytuł oryginału: Co-existence of apoptotic and necrotic features within one single cell as a result of menadione treatment.
    Autorzy: Kamiński Marcin, Karbowski Mariusz, Miyazaki Yu, Kędzior Jakub, Spodnik Jan Henryk, Gil Aleksandra, Woźniak Michał, Wakabayashi Takashi
    Źródło: Folia Morphol. 2002: 61 (4) s.217-220, il., bibliogr. 13 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study we examined the effects of menadione, a redox cycling agent, on structural changes of human osteosarcoma line 143B cells. It has been previosly reported that menadione can cause necrotic or apoptotic cell death in a concentration- depending manner. In our experimental model, cells were treated with 100 ćM menadione for 24 hours. Using electron microscopy technique cells carrying three kinds of morphological changes were detected: necrotic cells, apoptotic cells and those demonstrating a co-existence of apoptotic and necrotic features in one single cell.


    1337/2523

    Tytuł oryginału: Distribution of nitric oxide synthase and neuropeptide Y neurones during the development of the hippocampal formation in the rat.
    Autorzy: Moryś Joanna M., Kowiański Przemysław, Moryś Janusz
    Źródło: Folia Morphol. 2002: 61 (4) s.221-232, il., tab., bibliogr. 55 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Mitric oxide (NO) a short-liver radical, which modulates synaptic plasticity, neuronal oscillations and cerebral blood flow. NOS-containing neurones can be detected anatomically by nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry or by NOS immunohistochemistry. Neuropeptide Y (NPY) is the most abundant peptide in the brain. NPY is connected with several vital functions, such as a feeding behaviour, sexual maturation, regulation of circadian rhythms, body temperature, blood pressure and neuroendocrine secretions. Neuropeptide Y also modulates anxiety-related disorders, limbic epileptic seizures as well as learning and memory processes. The study was performed on 45 Wistar rats of various ages (P0, P4, P7, P10, P14, P21, P30, P60, and P120; P - postnatal day). The free-floating sections were stained with standard immunohistochemistry methods. Thereafter the histological sections were studied using the confocal laser microscope equipped. For 3D reconstruction the image analysis program LaserSharp 2000v. 2.0 (bio-Rad, UK) was used. We found that in the newborn rat both NOS- and NPY-immunoreactivity was weak. It had been increasing gradually until the 7th day of postnatal life, after that until P14 it was maintained on the similar level, and then the number of immunolabelled cells deceased. The developmental changes concerned cell morphology as well - until the 10th day of life the immunoreactive cells were immature, with round or oval bodies and had only a few fibres. From Pf14 the cells' morphology became similar to that in adult.


    1338/2523

    Tytuł oryginału: Differentiation of the cortical plate in early human foetuses.
    Autorzy: Rapalska Katarzyna, Woźniak Witold
    Źródło: Folia Morphol. 2002: 61 (4) s.233-236, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • in vitro

    Streszczenie angielskie: The aim of the study is to describe the differentiation of the cortical plate in human foetuses aged 9 - 11 weeks. Histological sections showed that in this early period of development the cortical plate is differentiated into two zones. The external zone is composed of vertical columns of cells, which are perpendicular to the cortical surface. The internal zone is wider and consists of irregularly arranged clusters of cells.


    1339/2523

    Tytuł oryginału: Mast cell density, neuronal hypertrophy and nerve growth factor expression in patients with acute appendicitis.
    Autorzy: Coskun Nigar, Sindel Muzaffer, Elpek Glsm ™zlem
    Źródło: Folia Morphol. 2002: 61 (4) s.237-243, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In acute appendicitis, although the relationship between the enteric nervous system (ENS) and mast cells (MCs) has been described in a few studies, neither the expression of nerve growth facor (NGF) nor its relation to mast cell density (MCD) and ENS has been delineated yet in this disease. The aim of this study was to immunohistochemically investigate the relationship between MCD, nervous system and NGF expression in the appendices of cases with clinically and histopathologically diagnosed acute appendicitis and of normal controls. Twenty-five patients with acute appendicitis and twelve normal controls were included in our study. Mast cell tryptase, PGP 9.5 and anti-NGF immunostained tissue sections were subjected to quantitative image analysis. Our results showed that MCD, the number of Schwann cells, the number and size of ganglia and NGF staining were significantly greater in acute appendicitis than in the control group (p 0.01). A strong correlation between MCD and NGF staining was detected (r = 0.92) only in cases with acute appendicitis. Similarly MCD was also related to neuronal proliferation and hypertrophy in this group. We failed to detect any relationship between NGF staining and neural components either in the acute appendicitis or control groups. Our findings indicate that mast cells could be one of the important cell populations responsible for nerve proliferation and hypertrophy in acute appendicitis. The relationship between NGF staining and MCD and the lack of correlation between NGF staining and changes in neural components suggest that, in acute appendicitis, NGF might be responsible for the increased number of MCs, but not for neuronal proliferation and hypertrophy.


    1340/2523

    Tytuł oryginału: Formation of synapses on the growth cones in human embryonic inferior ganglion of the vagus.
    Autorzy: Bruska Małgorzata
    Źródło: Folia Morphol. 2002: 61 (4) s.245-249, il., bibliogr. 20 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód

    Streszczenie angielskie: Ultrastructural study was performed on inferior ganglia of the vagus in human embryos age 7 and 8 weeks (developmental stages 18 to 23, 44 to 56 days). The growth cones are observed between the bundles of axons of the inferior ganglia of the vagus. Many primitive synapses (protosynapses) between dendritic and axonal growth cones are observed.


    1341/2523

    Tytuł oryginału: The neuronal structure of the globus pallidus in the rabbit - Nissl and Golgi studies.
    Autorzy: Wasilewska Barbara, Najdzion Janusz, Szteyn Stanisław
    Źródło: Folia Morphol. 2002: 61 (4) s.251-256, il., bibliogr. 44 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: The studies were carried out on the telencephalons of 12 adult rabbits. Two types of neurons were distinguished: 1. Large neurons (perikarya 18 - 40 ćm), which have from 2 to 6 thick, long primary dendrites. Their perikarya have a polygonal, triangular and fusiform shape. The large neurons in the centre of GP have radiated dendritic trees, whereas the dendritic field of the cells along the borders of GP has an elongated shape. The dendritic arbour is not homogenous. The dendrities may be covered with spindle-shaped dendritic swellings, bead-like processes, not numerous spines or they may be smooth as well. The dendritic branches from thin, beaded dendritic processes, that arise from any part of the dendritic tree, as well as "complex terminal endings", which have various types of appendages on their terminal portions. An axon emerges from a thick conical elongation either from the cell body or one of the dendritic trunks. These neurons are the most numerous in the investigated material. 2. Small nerve cells have been infrequent in our material. Their cell bodies are rounded or polygonal. From the perikarya there arise 2 - 4 thin dendritic trunks, which may have irregular swellings and few spines. The dendrites spread out in all directions, making the dendritic field round or oval in shape. Generally most axons of the small cells have not been impregnated. However, a few of them have a thin axon with a conical elongation, which emerges from the cell body and bifurcates into beaded processes.


    1342/2523

    Tytuł oryginału: Computed tomographic assisted study of morphological changes in the sutural areas as resulting from obliteration.
    Autorzy: Skrzat Janusz, Brzegowy Paweł, Walocha Jerzy
    Źródło: Folia Morphol. 2002: 61 (4) s.257-259, il., bibliogr. 8 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The authors have studied the morphological differences of sutural areas in humanskulls at distinct stages of obliteration. A computed tomography aided with computer algorithm of tonal correction was applied to visualise structural changes in the sutural areas that are correlated with sutural osscification. The results of our study suggest that obliteration of cranial sutures is accompanied by local fluctuations of bony density in sutural areas, gradual unification of structural density towards ectocranium. When the obliteration proceeds, the sutural gap ceases. The laminas and diploic layers of the two opposing bones become a single structure of increased integrity.


    1343/2523

    Tytuł oryginału: Divergent effects of quinolinic aminoxyls on mitochondrial ultrastructure and localisation in osteosarcoma 143 B cells.
    Autorzy: Spodnik Jan Henryk, Kędzior Jakub, Gil Aleksandra, Woźniak Michał, Wakabayashi Takashi, Falcioni Giancarlo, Greci Lucedio
    Źródło: Folia Morphol. 2002: 61 (4) s.261-264, il., bibliogr. 18 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study we have shown that quinolinic aromatic aminoxyls are very efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide-induced oxidation. The efficacy of these aminoxyls as protectors of lipids was much higher than the water-soluble 4-OH-TEMPO. We have also shown that QAL causes distinct changes of the morphology of mitochondria: from filamentous to granular enlarged structure via the folding of the former. QAL induces also perinuclear clustering of mitochondria. C-QAL as well as 4-OH-TEMPO treated cells revealed filamentous and scattered pattern of mitochondria. Antioxidant activity of QAL as well as morphological changes of mitochondrial raise the possibility that this drug can affect cell physiology via changes of mitochondrial function.


    1344/2523

    Tytuł oryginału: The neuronal structure of the medial geniculate body in the pig -Nissl and Golgi study.
    Autorzy: Bogus-Nowakowska Krystyna, Szteyn Stanisław, Robak Anna
    Źródło: Folia Morphol. 2002: 61 (4) s.271-276, il., bibliogr. 39 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie angielskie: The studies were carried out on the brains of adult pigs. The preparations were made by means of the Golgi technique as well as the Nissl and Klver-Barrera methods. Four types of neurons were described in the medial geniculate body (MGB) of the pig: 1. Multipolar neurons (perikarya 30 - 45 ćm) with rounded, oval or quadrangular perikarya from which arise 4 - 7 dendritic trunks. The dendrites divide dichotomically twice, may send out collaterals and give off ramifications. The dendritic branches possess varicosities and knob-like spines. These neurons predominate in MGB. 2. Pear-shaped neurons (20 - 35 ćm) with one or two dendritic trunks arising from one pole of the cell body. These dendrites have a tufted appearance. 3. Triangular neurons (30 - 45 ćm) possess three thick dendrites which first bifurcate near the soma and then divide profusely into daughter branches. 4. Fusiform neurons (30 - 50 ćm) have usually two dendritic trunks which arise from the opposite poles of the cell body and divide dichotomically twice. The fusiform neurons are the least numerous in MGB. Most MGB neurons have on the secondary tertiary dendrites and on their ramifications have delicate varicose or bead-like appendages and spine-like protrusions. In all types of neurons an axon arises either from the soma or from the initial portion of the dendritic trunk.


    1345/2523

    Tytuł oryginału: Sciatic nerve variations in some studies on the Polish population and its statistical significance.
    Autorzy: Okraszewska Ewa, Migdalski Łukasz, Jędrzejewski Kazimierz S., Bolanowski Wojciech
    Źródło: Folia Morphol. 2002: 61 (4) s.277-282, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The purpose of the study was to describe and analyse sciatic nerve variation in a relatively small, yeat statistically significant, group. Consequently, a comparison of described variation to that known from former studies was performed. Additonally, we estimated the minimum group necessary for a statistical confirmation of hypothetical differences in sciatic nerve topography between the studied.


    1346/2523

    Tytuł oryginału: The arrangement of muscle fibres in the region of the subthebesian fossa in the aspect of atrial flutter.
    Autorzy: Kozłowski Dariusz, Owerczuk Adam, Piwko Grzegorz, Piszczatowska Grażyna, Kozłowska Magdalena, Bigus Krzysztof, Grzybiak Marek
    Źródło: Folia Morphol. 2002: 61 (4) s.283-289, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The typical atrial flutter is the most common supraventricular tachycardia with reentrant circuit. This tachyarrythmia is based on macroreentry wave going around established anatomic landmarks. The reentry in the inferior right atrial wall passes through narrow isthmus, which is the goal for ablative therapy. The isthmus area is bordered anteriorly by the tricuspid valve and posteriorly by the inferior vena cava, coronary sinus, and eustachian ridge. Near to this area we can find anatomical structure, which can be very important during arising, perpetuation and curing of atrial flutter. The concavity, so-called subthebesian fossa [15], is on the way of typical atrial flutters' reentrant circuit. Regarding the facts mentioned above we decided to examine the morphology and the arrangement of the muscle fibres in this fossa. Research was conducted on material consisting of 70 human hearts of both sexes from the age of 34 ot 72 years. 50 hearts came from patients whose death was not cardiologic in origin. 20 hearts came from humans in whose common atrial flutter was confirmed. We observed the arangement of muscle fibres in the area of subthebesian fossa. Besides we measured the size and deepness of the subthebesian fossa in both groups of hearts. We found that regular arrangement of muscle fibres within subthebesian fossa was present in 23 healthy human hearts (46 p.c.) and 7 cases (35 p.c.) of hearts with atrial flutter. The irregular arrangement of muscle fibres was observed in 27 hearts (54 p.c.) of control group and 13 hearts (65 p.c.) with dysrrhythmia. The thickness of...


    1347/2523

    Tytuł oryginału: Arterial supply of the olfactory trigone and the anterior perforated substance in macrosmatic and microsmatic animals.
    Autorzy: Nachman Ewa, Topol Mirosław
    Źródło: Folia Morphol. 2002: 61 (4) s.265-269, il., bibliogr. 18 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • koty
  • małpy

    Streszczenie angielskie: An investigation was conducted into the differences between macrosmatic and microsmatic animals if arterial supply in the area of the olfactory trigone and the anterior perforated substance. A brain of domestic cat was taken as an example of a macrosmatic animal and a brain of baboon as an example of a micorsmatic animal. The cerebral blood vessels of the cadavers of 30 cats and 11 baboons were filled with latex and, after fixation in acid alcohol by means of microscopic operation, the cortical and deep branches of the anterior and middle cerebral artieres were dissected. We discovered that there were differences between these two groups of animals in the places of arising of deep branches and in their course. In the cat the deep branches running through the area of the olfactory trigone arose from the beginning part of the middle cerebral artery in numbers 5 - 10 and entered the brain in the olfactory tubercle. In the baboon the deep branches arose from two sources: the middle cerebral artery and the anterior cerebral artery. The branches of the middle cerebral artery went through the anterior perforated substance, forming two groups of branches: lateral and medial.


    1348/2523

    Tytuł oryginału: Localisation of focal liver lesions to specific hepatic segments - comparison of multiphase spiral CT and MR imaging.
    Autorzy: Bobek-Billewicz Barbara, Szurowska Edyta, Zapaśnik Adam, Iżycka-Świeszewska Ewa, Gorycki Tomasz, Nowakowski Marek
    Źródło: Folia Morphol. 2002: 61 (4) s.291-297, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: The purpose of this study was an evaluation of the ability of the multiphase spiral CT and MR imaging to localise focal liver lesions in 26 patients who had undergone spiral CT and MRI before surgery. Multiphase spiral CT included noncontrast scans, hepatic arterial-dominant phase, protal venous - dominant phase and equilibrium phase. MRI was performed in all cases. The following sequences were performed: SE and SE T1 - and T2-weighted images, STIR and dynamic T1-weighted FFE study after i.v. administration of gadolinium (Gd-DTPA). The CT and MR scans were prospectively and independently reviewed by three radiologists for visualisation of hepatic and portal veins and segmental localisation of hepatic lesions. The authors used the right and left main portal veins along with transverse fissura, hepatic veins and galbladder fossa as landmarks for the tumour localisation to specific hepatic segments. The primary segmental localtions of the lesions were corectly determined with CT in 22 of 26 focal liver lesions (85 p.c.) and with MR imaging in 25 of 26 lesions (92 p.c.). The full extent of lesions was correctly described with sCT in 19 of 26 focal lesions and with MR in 21 of 26 tumours. MRI and CT were helpful preoperative tools for determining the segmental location of focal liver lesions and for planning the surgical approach.


    1349/2523

    Tytuł oryginału: Analysis of operating field area in transpyramidal retrolabyrinthine approach to posterior cranial fossa.
    Autorzy: Nitek Stanisław, Wysocki Jarosław, Brożek Eliza
    Źródło: Folia Morphol. 2002: 61 (4) s.305-308, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Retrolabyrinthine surgical access to the posterior and middle cranial fossa has a long history of use during the procedures aiming at the removal of small neoplasmatic changes located in the area of the internal auditory tube. A precise knowledge of teh anatomical alterations of teh temporal bone in the aspect of the retrolabyrinthine access to the posterior caranial fossa determiens a successful otoneurosurgical endoscopy, which involves a relatively narrow area. Fortyfour cadaver temporal bones of both sexes were measured to obtain the dimensions of teh surgical area limited by the sigmoid sinus, superior petrosal sinus and posterior labyrinth. The techniques of computer picture analysis were applied in the research. The mean value of the surface area of the figure limited by the sigmoid sinus, superior petrosal sinus and posterior semicircular canal was 175.9 mmý with no significant differences between sexes and sides. The maximal measured value was 356 mmý, and the minimal was 84.3 mmý. The size of the surgical area is characterised by large deviation range but was always sufficient to insert the endoscopic device and standard otosurgical instruments.


    1350/2523

    Tytuł oryginału: Intravascular ultrasound assessment of blood vessel morphology.
    Autorzy: Chrzanowski Łukasz, Jędrzejewski Kazimierz
    Źródło: Folia Morphol. 2002: 61 (4) s.309-312, il., bibliogr. 10 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Intravascular ultrasound (IVUS) is an invasive imaging technique, characterized by the ability to depict the tomographic section of blood vessels' lumen and wall. Thus, it enables the performance of a unique in-vivo assessment of the luminal area and three-layer wall morphology, as well as atherosclerosis within the vessel. The typical composition of an IVUS image and the measuements of observed structures have been shown to correlate well with histology and angioscopy in several in vitro studies. The existing data on intravascualr imaging of the aorta are scant. In this study, the preliminary results of in-vitro IVUS examination of human descending aorta morphology are presented, with reference to the corresponding histological section.


    1351/2523

    Tytuł oryginału: Application of a mixture of glycol polyethylenes for the preparation of microcorrosion casts - an observation.
    Autorzy: Walocha Jerzy A., Miodoński Adam J., Nowogrodzka-Zagórska Maria, Kuciel Radosława, Gorczyca Janusz
    Źródło: Folia Morphol. 2002: 61 (4) s.313-316, tab., bibliogr. 22 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Preparation of microcorrosion casts that can be used for obsrvation in SEM is a laborious, time-consuming precedure. The authors paid particular attention to the process of dissection of the microcorrosion casts. This prompted the authors to reconstruct the plastic mass, produced by the firm Gurr (Great Britain) in the 1970s, which was used by them in previous research to immerse the cast in order to minimise the damage. By using easily obtainable polyethylene glycols, characterised by different physical and chemical features , in order to obtain smooth surface of the section, a low-toxic mixture was composed, which protected the microcorrosion casts sufficiently and did not interfere with the physical and chemical properties of the cast.


    1352/2523

    Tytuł oryginału: Multiple muscular variations in the neck region - case study.
    Autorzy: Coskun Nigar, Yildirim Fatos Belgin, Ozkan Olcay
    Źródło: Folia Morphol. 2002: 61 (4) s.317-319, il., bibliogr. 10 poz.
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • praca kliniczna
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: During routine educational dissection studies, we encountered multiple muscular anomalies in a 25-year-old embalmed male cadaver. The muscular anomalies were observed on the right side. In accordance with theri origin, insertion and innervation features, the abormal muscles were considered sternocleidoccipital, sternomastoid and cleidomastoid muscles. The unilateral muscle variations were observed in both the superficial and deep layer. In the superficial layer, there were two muscles and one muscle bundle, while there was only one muscle in the deep layer. THe first muscle in the superficial layer, known as sternocleidooccipital muscle, consisted of clavicular head and sternal head. The second muscle in the superficial layer was sternomastoid muscle. The muscle observed in the deep layer was cleidomastoid muscle. Additionally, a muscular bundle was observed between the sternocleidoccipital and sternomastoid muscles. A combination of these variations in the same case has not, to our knowledge, been previously described in the available literature.


    1353/2523

    Tytuł oryginału: Report on the activities of the Polish Anatomical Society in 2001.
    Autorzy: Szteyn Stanisław, Jankowska-Steifer Ewa
    Źródło: Folia Morphol. 2002: 61 (4) s.321-322
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • sprawozdanie
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Polskie Towarzystwo Anatomiczne


    1354/2523

    Tytuł oryginału: Exposure and respiratory health in farming in temperate zones - a review of the literature.
    Autorzy: Omland íyvind
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.119-136, tab., bibliogr. 125 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: To review studies in farming populations from temperate zones focusing on: (1) exposure to duse, bacteria, moulds, endotoxin, and ammonia, (2) sensitisation to common airborne allergens, (3) prevalence, incidence and risk factors of chronic bronchitis, asthma and bronchial hyperresponsiveness, and (4) measurements of lung function. Workinag in animal housings can be associated with exposure to organic dust, bacteria, moulds, endotoxin, and ammonia in concentrations that can induce cellular and immunological responses and result in respiratory diseases. Working in poultry housing might be associated with higher exposures to dust, bacteria, and ammonia than in swine and cow housings, and endotoxin exposure seems to be higher in North America than in Europe. Working exposure might inluence the domestic area on farms, and there might be a protective effect of being raised on a farm regarding sensitisation and allergic diseases. Sensitisation to mites seems to be the most prevalent of the common inhalant allergens. Chronic bronchaitis is frequent and data suggests that it is work related in farmers. Findings concaerning asthma are less uniform, and data regarding bronchial hyperresponsiveness are too sparse and inconsistent to evaluate the effect on farming. Several risk factors have been described, and age is shared for all three clinical manifestations, while male gender, atopy, smoking, pig farming, and animal production are common risk factors for chronic bronchitis and asthma. FEC1, and FEV2/FVC seems to be reduced in farmers, and longitudinal studies indicate an increased...


    1355/2523

    Tytuł oryginału: Antigenic and allergenic properties of Amaranthus spinosus Pollen - a commonly growing weed in India.
    Autorzy: Singh Anand B., Dahiya Pushpa
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.147-151, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Amaranthus spinosus (Fam. Amaranthaceae) is an important aeroallergen in India and grows commonly in different parts of the country. In spite of its clinical significance in Type I hypersensitivity disorders, the antigenic and the allergenic properties of the epollen have not been systematically resolved. We investigated antigenic and allergenic properties of 5 pollen samples of Amaranthus spinosus collected from the Delhi area of fortinghtly intervals. The protein content did not exhibit statistically significant variability. However, samples collected during the peak flowering season showed higher protein content. Biochemical characterization of samples showed multiple protein fractions bay IEF and SDS-PAGE analysis. Samples collecated during peak sesason showed a slightly higher number of bands (22) in the mw range of 14-70 kD. Seven protein fractions of 70, 66, 60, 50, 40, 30 and 14 kD were observed to have IgE binding capabilities and 9 were treated as allergenic. The observations will be helpful in standardizing pollen antigens for diagnosis and immunotherapy in India.


    1356/2523

    Tytuł oryginału: Hearing loss among private farmers in the light of current criteria for diminished sense of hearing.
    Autorzy: Solecki Leszek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.157-162, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • otorynolaryngologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The study covered a group of 128 private farmers aged 28-65 (mean age 47.2) who had a period of occupational activity of 11-40 years (23.9 yeras average). The evaluation of hearing capability was based on 2 calculated values: PTA (mean from frequency: 0.5; 1; 2 and 3 kHz) and HFA (mean from 3; 4; and 6 kHz). Statisticallysignificant differences in mean hearing loss were observed between the 2 groups in the study; farmers - coantrol group (p 0.001). The value of 20 dB was adopted as a criterion of the deterioration of hearing. This ciriterion was exceeded in 78 p.c. of farmers examined - within the range of high frequencies (HFA), and in 45 p.c. of farmers within the range of medium frequencies (PTA). In the control group, abnormal hearing loss was noted in 17 p.c. of people only for mean HFA valued. In the group of farmers a significant correlation was noted between hearing loss (PTA and HFA) and agae, as well as period of occupational activity. It was statistically confirmed that the most significant decrease in hearing occurred during the age interval up to the age of 50 and durint the period of occupational activity of up to 30 years. The results of thh study confirmed that noise present in the agricultural environment is the primary cause of the decrease in hearing among private farmers.


    1357/2523

    Tytuł oryginału: A controlled intervention study concerning the effect of intended temperature rise on house dust mite load.
    Autorzy: Sidenius Kirsten E., Hallas Thorkil E., Poulsen Lars K., Mosbech Holger
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.163-168, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 313,158

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: In epidemiological studies, increased indoor temperature - producing a lower relative humidity - is associated with low house dust mite (HDM) load. Twenty-eightdwellings were allocated for either intervention (f12/15 completed) or control (11/13 completed). In the intervention group, participants were asked to increase the bedroom temperature bay at least 3řC compared to the self-assessed temperature of the previous winter. Dust samples were repeatedly collected from mattress and floor, and bedroom temperature and relative humidity were recorded hourly throughout one year. Dusts was analysed for allergen (Der f 1 + Der p 1 + Der m 1 = Der 1) by ELISA and HDMs were counted. Changes in mite and in mite allergen concentration were the same in the control and intervention groups, and measured temperatures did not differ during intervention period in the groups (18řC and 19řC). Groups turned out not to be comparabale with respect to initial (self-assessed) bedroom temperature (lowest in the intervention group). There was a significant seasonal variation, with doubled Der 1 concentrations in dust collected in July-November compared to January-May samples. No effect was obtained on mites or mite allergens, but this may be due either to a general lack of effect of increase in bedroom temperature, or to an insufficient increase in temperature in our intervention group. Seasonal variations in HDM and HDM allergens must be accounted for when data on exposure are interpreted.


    1358/2523

    Tytuł oryginału: Disorders of the musculoskeletal system among dentists from the aspect of ergonomics and prophylaxis.
    Autorzy: Szymańska Jolanta
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.169-173, tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The profession of dentist exposes them during their work to many burdensome and harmful factors. The irrational posture adopted by dentists during their work causes discomfort and disorders of the musculoskeletal system and the peripheral nervous system. The methods and organization of the work of Polish dentists were evaluated from the aspecat of ergonomics, with regard to reported by them painful disorders connected with the musculoskeletal system, with the aim of applying proper methods of treatment and prpohylaxis. The study showed that dentists worked in conditions which generally produced disorders of the musculoskeletal system. As a result, the long working time in the course of a day was used irrationally from the point of view of ergonomics, which over the years of work consequently increased the number of disorders of the musculoskeletal system. Dentists must make use of various forms of treatment. The effectiveness of prophylaxis concerning the musculoskeletal system were only partly assessed by the respondents through questionnaire. Most dentists are convinced of the effectiveness of physical activity in prophylaxis which they carry out themselves.


    1359/2523

    Tytuł oryginału: Hematological alternations after pyrethroids poisoning in mice.
    Autorzy: Haratym-Maj Agnieszka
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.199-206, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was evaluation of the effect of ŕ-cypermethrin, deltamethrin or fenvalerate poisoning on hematological parameters in male and female Swiss mice in suba-acute poisoning. All pyrethroids examined, irrespecataive of the dose and sex of animals, caused an increase in the number of leukocytes in peripheral blood. In ŕ-cypermethrin poisoning no changes in the hematological parameters were obseraved in male mice, wheras in female animals the administration of a lower ŕ-cypermethrine dose resulted in an inhibition, and a higher dose in mobilization of hemopoietic system. In male mice poisoned with deltamethrin or fenvalerate, mobilization of the hemopoietic system was noted. No changes in the hematological parameters were observed in female mice poisoned with a higher deltamethrin dose. In female animals which were administered a lower deltamethrin dose or fenvalerate a decrease was noted in the number of erythrocytes, as well as hemoglobin and hematocrit levels.


    1360/2523

    Tytuł oryginału: The prevalence of piroplasms in a population of Ixodes ricinus (Acari: Ixodidae) from North-Western Poland.
    Autorzy: Kuźna-Grygiel Wanda, Bukowska Katarzyna, Cichocka Agnieszka, Kosik-Bogacka Danuta, Skotarczak Bogumiła
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.175-178, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Developmental forms of Babesia spp. were studied in isolated salivary glands of Ixodes ricinus, subjected to the Feulgen reaction. The same ticks were also host to Babesia microti, which was determined by PCR amplification with primers specific to the fragemnt of a gene encoding the nuclear small subunit ribosomal RNA (SS-rDNA). Presence of Babesia spp. was recorded in the salivary glands of 59.9 p.c. of ticks collected, both in nymphs and adults. PCR reactions specific to Babesia microti were positive in 1.9 p.c. of nymphs.


    1361/2523

    Tytuł oryginału: Occurrence of enterotoxigenic Staphylococcus aureus in food.
    Autorzy: Holeckova Beata, Holoda Emil, Fotta Marian, Kalinacaova Viera, Gondol Julius, Grolmus Jan
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.179-182, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Gastroenteritis is one of the most frequent microbial diseases, which is caused by the ingestion of food contaminated with staphylococcal enterotoxins. In our study, the production of staphylococcal enterotoxins A, B (SEA, SEB) and the presence of respectiave staphylococcal enterotoxin genes were investigated in the field S. aureus isolates obatained from foods and food industry manufactures in East Slovakia. Radioimmunoassay (RIA), polymerase chain reaction (PCR) and dit-baalot hybaridisation were used for examination. The ability to synthetise enterotoxins was found in 20 (39.2 p.c.) of the total number of 51 isolates. Production of SAW was recorded in 3 (5.9 p.c.), production of SEB in 12 (23.5 p.c.) and production SEA together with SEB in 5 (9.8 p.c.) staphylococcal isolates. Nine (47.4 p.c.) sheep cheese isolates of the total number of 19 produced enterotoxins, especially SEB (36.8 p.c.). S. aureus isolates from pasta were enterotoxigenic in 6 cases (33.3 p.c.). The synthesis of enterotoxings was not detected in Bryndza cheese and sausages isolates. One enterotoxigenic isolate was obatained from smears of technological equipment and 4 isolates from throat and nasal swabs. No differences in results were recorded between RIA and PCR as well as PCR and dot-blot hybridisation. Our results suggest that ist is of special importance to follow the presence of enterotoxigenic S. aureus strains in foodstuffs, especially for protecting the consumers from food poisoning.


    1362/2523

    Tytuł oryginału: Toxin producing micromycetes on fruit, berries, and vegetables.
    Autorzy: Lugauskas Albinas, Stakeniene Jurgita
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.183-197, tab., bibliogr. 51 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In 1999-2001 the investigations on mycological state of stored and sold fruit, berries, and vegetables grown in Lithuania and imported from other countries were performed. The samples of foodstuff were taken from storehouses, various supermakets, and market places. Such ecological conditions lead to a rapid spreading of micormycetes and contamination of other articles of food stored and sold nearby. On fresh fruit and berries the development of microorganisms is slow. However, microorganisms penetrate into internal tissuees of berries and fruit, thus becoming difficult to notice vasually. Some microorganisms, especially micromycetes of some species belonging to the Penicillium Link, Aspergillus Mich. ex Fr., and other genera, are able to produce secondary metabolites (mycotoxins) of various compostitions that are toxic to plants, animals, and humans. Therefore, the ability of micromycetes to synthesisse and excrete toxic secondary metabolites was examined. Considering this issue, 393 micromycete strains ascribed to 54 genera and 176 species were tested. 46 strains were identified as active producers of toxic substances and were selected for further examinations. Most of them belonged to the Penicillium, Aspergillus and Fusarium genera. Their detection frequency on the investigated berries, fruit, and vegetables was determinedd, and the impact upon warm-ablooded animals (BALB/c mice) was tested. Significant changes of the internal organs and blood composition were found in mice infecated with toxic micromycetes. In conclusion, it was evidenced that more than 10 p.c. of micromycete strains...


    1363/2523

    Tytuł oryginału: Magnetic resonance imaging of the heart.
    Tytuł polski: Obrazowanie serca metodą rezonansu magnetycznego.
    Autorzy: Sandstede J”rn J. W., Beer Meinrad, Pabst Thomas, K”stler Herbert, Kenn Werner, Neubauer Stefan, Hahn Dietbert
    Źródło: Prz. Lek. 2002: 59 (8) s.595-600, il., bibliogr. 38 poz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1364/2523

    Tytuł oryginału: Cytological and morphological differences between two species of the genus Tettigonia (Orthoptera, Tettigoniidae) from Korea.
    Autorzy: Warchałowska-Śliwa Elżbieta, Kostia Dariusz, Śliwa Leopold
    Źródło: Folia Biol. 2002: 50 (1/2) s.23-28, il., bibliogr. s. 28
    Sygnatura GBL: 302,991

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Tettigonia ussuriana and T. dolichopoda maritima differ in the length of tegmina, details in venation, and in females in details of the subgenital plate. The two speices of the genus Tettigonia have the same number and morphology of autosomes but a different morphology of the X chromosome: in T. ussuriana it is metacentric, whereas in T. dolichopoda maritima acrocentric. In both species, euchromatic zones and breaks of one or to chromatids during meiosis and mitosis in the X chromosome were observed. Additionally, B chromosomes were noted in most individuals of both species.


    1365/2523

    Tytuł oryginału: Gene polymorphisms of the renin-angiotensin-aldosterone system and essential arterial hypertension in childhood.
    Autorzy: Petrović Danijel, Bidovec Matja, Peterlin Borut
    Źródło: Folia Biol. 2002: 50 (1/2) s.53-56, tab., bibliogr. s. 56
    Sygnatura GBL: 302,991

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: In order to investigate the contribution of candidate genes in the renin-angiotensin-aldosterone system (RAAS) in pathogenesis of essential arterial hypertension (EAH), the I/D polymorphism of ACE gene, the M235T polymorphism of the angiotensinogen gene, and the angiotensin II type 1 receptor (AGT1R) A1166C gene polymorphism in a group of children with EAH were analyzed. Fifty-seven children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared with 57 subjects with normal blood pressure (the control group). Arterial hypertension was defined as systolic/diastolic blood pressure measurments higher than 95 age-gender-height percentile of the adopted reference values. A trend was found towards an association between the M235T angiotensinogen gene polymorphism and EAH in childgood in a dominant model (odds ratio (OR) 2.1; 95 p.c. confidence interval (CI) 0.9 - 5.1; P = 0.077), whereas the authors failed to demonstrate an association between the ACE I/D gene polymorphism, or the A1166C AGT1R gene polymorphism and EAH in childhood. Additionally, evidence was found of interaction between the angiotensinogen-TT genotype and obesity on the risk of EAH in childhood (OR 19.3; 95 p.c. CI 1.1 - 77.3; P = 0.014). In conclusion, the M235T angiotensinogen gene polymorphism is considered alone as well as in interaction with obesity to be risk factors for EAH in childhood.


    1366/2523

    Tytuł oryginału: Effect of thyroxine on some digestive enzymes of the adult male toad, Bufo melanostictus.
    Autorzy: Bhattacharyya Sanat K., Chaki Korak K., Misra Kamales K.
    Źródło: Folia Biol. 2002: 50 (1/2) s.83-90, tab., bibliogr. s. 89-90
    Sygnatura GBL: 302,991

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Żaby
  • płeć męska

    Streszczenie angielskie: Thyroxine is known to play an important role during the developmental process of amphibians. The present work is designed on the hypothesis that a functional relationship exists between the thyroid gland and digestive physiology in the adult toad. Three doese of thyroxine (25 ćg/100 g; 50 ćg/100 g; 100 ćg/100 ćg body weight) were orally administered daily to the adult male toad, Bufo melanostictus and changes in -amylase, pepsin, trypsin, and esterase activities of the different zones of the digestive tract, pancreas and liver were observed. The observations were made on 7, 15, and 30 days of thyroxine treatment. The result shows that the dose of 25 ćg increases the enzyme activities in the gastrointesinal tract, liver and pancreas of 7 days treatment. However, prolonged treatment with all the doses shows little effect on these enzymes. The pattern of changes in the enzymatic activities in the digestive tract of the adult male toads show more advanced compartmentalizaiton than that of fishes. It is also found that site-specific enzyme production is not pronounced in this amphibious vertebrate. It is proposed that a positive functional relationship between thyroxine and digestive enzymes exists in the adult male toad.


    1367/2523

    Tytuł oryginału: Retrograde iliac endarterectomy - modified technique combining conventiomal surgical and interventional procedures.
    Autorzy: Schr”der Alfred, Mckner Kersten, Vogel Steffen
    Źródło: Acta Angiol. 2002: 8 (4) s.143-146, il., bibliogr. 6 poz.
    Sygnatura GBL: 313,274

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background. Retrograde ring-stripper endartectomy of iliac arteries throught an inguinal approach modified by combining interventiuonal procedures. Material and methods. 52 iliac arteries underwent modified retrograde ring-stripper endartectomy. Passage of the lesions with a giude wire permits endarterectomy over the wire as a central splint under fluoroscopic control. Resiudual lesions are corrected by ballon or stent angioplasty. Results. Conversion to a conventional operation was required in 8 limbs. Initial technical success was was achieved in 44 limbs. Cumulative secondary patience was 95.8 p.c. at 24 months (S.E. 4.7 p.c.). Conclusion. Modified ring-stripper endarectomy witrh angioplasty is a safe and effective procedure. Long-term results are reqiured.


    1368/2523

    Tytuł oryginału: Elevated neuropeptide Y plasma concentration in non-dippers with essential hypertension.
    Tytuł polski: Podwyższone stężenie neuropeptydu Y we krwi u chorych z nadciśnieniem tętniczym pierwotnym i brakiem nocnego obniżenia ciśnienia tętniczego.
    Autorzy: Łapiński Mariusz, Januszewicz Andrzej, Lewandowski Jacek, Symonides Bartosz, Kuch-Wocial Agnieszka, Wocial Bożena, Ignatowska-Świtalska Hanna
    Źródło: Nadciśn. Tętn. 2002: 6 (1) s.9-15, il., tab., bibliogr. 33 poz., streszcz.
    Sygnatura GBL: 313,470

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp. Brak nocnego obniżenia ciśnienia tętniczego prowadzi do zwiększonej częstości powikłań narządowych nadciśnienia tętniczego, a jego przyczyny pozostają niejasne. Celem pracy była ocena zależności między biochemicznymi wykładnikami aktywności współczulnej a rytmem dobowym ciśnienia u chorych z pierwotnym nadciśnieniem tętniczym. Materiał i metody. Da badania zakwalifikowano 68 chorych z nadciśnieniem tętniczym w średnim wieku 40 ń 1 lat (20 K, 48 M). Do grupy kontrolnej włączono 25 zdrowych ochotników w średnim wieku 38 ń 1 lat (8 K i 17 M). U badanych wykonywano 24-godzinny pomiar ciśnienia (SpaceLabs 90207) oraz oznaczano we krwi stężenie katecholamin i neuropeptydu Y. Całodobowo prowadzono zbiórkę moczu w celu oznaczenia wydalania katecholamin. Wyniki. U chorych z nadciśnieniem tętniczym stężenie neuropeptydu Y było wyższe niż u osób zdrowych. Stężenie katecholamin w surowicy i ich wydalanie z moczem były w obu grupach podobne. Chorych z nadciśnieniem podzielono na dwie grupy zależnie od obecności - dippers (46 chorych) - lub braku nocnego obniżenia ciśnienia - non-dippers (22 chorych). Stężenie neuropeptydu Y było istotnie wyższe w grupie non-dippers niż w grupie dippers (10,6 ń 1 vs. 8,6 ń 1 fmol/ml, p 0,05). Nie stwierdzono między grupami różnic w zakresie stężenia katecholamin w surowicy i katecholamin wydalanych z moczem. W obu grupach wydalanie katecholamin w czasie nocy było istotnie niższe aniżeli w ciągu dnia. Nocne i dzienne wydalanie katecholamin było podobne w grupie dippers i non-dippers. Wnioski. Uzyskane wyniki wskazują, że neurpeptyd Y może wpływać...


    1369/2523

    Tytuł oryginału: Synthesis pyrymidin-8-on (2,1-F) theophylline-9-alkyl carboxylic acids derivatives acting on CNS and cardio-vascular system : [doctorate thesis]
    Autorzy: Fhid Omeran
    Opracowanie edytorskie: Pawłowski Maciej (supervis.).; Uniwersytet Jagielloński Collegium Medicum,, Katedra Chemii Farmaceutycznej w Krakowie
    Źródło: 2002, 130 k. : tab., bibliogr. 97 poz., maszyn.
    Sygnatura GBL: 45/19878

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca doktorska
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    1370/2523

    Tytuł oryginału: The quality of life in patients suffer from resistant ascites treated with intraperitoneal infusion of hr TNF ŕ.
    Autorzy: Nowakowska-Zajdel Ewa, Muc-Wierzgoń Małgorzata, Zubelewicz-Szkodzińska Barbara, Wierzgoń Janusz, Klakla Katarzyna, Kokot Teresa, Kozowicz Andrzej, Cichocka Mirosława
    Źródło: Ann. Acad. Med. Siles. 2002: 50/51 s.73-79, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,709

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1371/2523

    Tytuł oryginału: Molecular epidemiology in preventive medicine - rationale and expectations.
    Autorzy: Jędrychowski Wiesław A., Perera Frederica P.
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.3-18, il., tab., bibliogr. 33 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: There are four major for with biomarkers may be used in epidemiological research: (1) to improve the assessment of exposure; (2) to identify subgroups of persons of different susceptibility to the effects of the exposure; (3) to measure early health outcome with some predictive significance; and (4) to differentiate disease subtypes with potentially different aetiologies. The least explored in epidemiological research is early health outcome measures to predict the occurence of clinical disease and to elucidate the biological mechanism of pathogenesis. This use is conceptually more complex than rather simple and the well-estabilished use of biomarkers to improve exposure assessment or to study interindividual variations in disease susceptibility. In principle, this form of use could accelerate or otherwise facilitate etiological research. For the etiologic studies biomarkers should (1) be on the causal pathway, (2) have a high probability of progression to clinical disease, and (3) account for all or most of the cases of the specified clinical outcome. Such biomarkers would be useful provided they presented a long lead-time relative to clinical disease occurrence. Biomarkers with good predictivity of a disease may be used for: (1) screening for pre-clinical disease; (2) enhancement of conventional epidemiological studies of diseases aectiology; (3) monitoring for variation or change in population health risk ; and (4) evaluation and monitoring of primary prevention measures.


    1372/2523

    Tytuł oryginału: Molecular basis of endothelial dysfunction and its correction.
    Autorzy: Gryglewski Ryszard
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.19-25, bibliogr. 42 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1373/2523

    Tytuł oryginału: Molecular epidemiology in cancer prevention.
    Autorzy: Perera Frederica P.
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.29-48, bibliogr. 136 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cancer prevention has been the stated goal of molecular cancer epidemiology for the past 17 years; and much has been written about its promise and potential. Using the exampples of four well studied environmentall carcinogens - tobacco smoke, polycyclic aromatic hydrocarbons, aflatoxin B1, and benzene - and their role in lung, breast, liver cancer and leukemia, we can trace the progress of molecular epidemiology, asking "How far have we come toward the goal of prevention?" This review demonstrates that molecular epidemiology has made important contributions in identifying causal factors in cancer, in documenting the major role of individual susceptibility in risk from environmental carcinogens, and in developing new interventions. In particular, the research has underscored the importance of focusing interventions (regulations, public education programs, health surveillance, behavior modification programs, and chemoprevention strategies) on subgroups at greatest risk as a result of genetic and/or acquired susceptibility. But the translation of research to risk assessment and preventive health policy has not yet happened in a meaningful way. Thus a priority is the incorporation of existing scientific data on differential susceptibility into risk assessment and the creation of an infrastructure to further this process by linkings scientists, policymakers, and other constituencies.


    1374/2523

    Tytuł oryginału: Prostate cancer susceptibility: a role for interactions between polymorphic genes and exposure to ultraviolet radiation.
    Autorzy: Bodiwala Dhaval, Luscombe Christopher J., French Michael E., Liu Samson, Saxby Mark F., Jones Peter W., Ramachandran Sudarshan, Fryer Anthony A., Grant William B., Strange Richard C.
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.49-58, il., tab., bibliogr. 33 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia
  • radiologia
  • urologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1375/2523

    Tytuł oryginału: Formation of DNA adducts and environmental exposures to airborne carcinogens.
    Autorzy: Peluso Marco, Munnia Armelle
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.59-68, tab., bibliogr. 32 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The incomplete combustion of organic matter results in the release of mixtures of greenhouse gases and other airborne pyrolysis products, including polycyclic aromatic hydrocarbons, which are capable to form dNA adduct after metabolic activation. DNA addducts are a biomarker that reveals xenobiotic exposure, possibly predictive of cancer risk. We have examined the association between environmental exposures and DNA adducts in selected dosimeter studies. In the Epic-Florence cohort, DNA adducts were significantly higher for traffic workers in respect to random sample. Urban residents tended also to show higher DNA adduct levels than those resident in suburban areas. In a meta-analysis of thirteen 32-postlabelling studies on occupational cohorts, the formation of DNA adducts was significantly associated with external levels of air pollutants, such as benzo(a)pyrene. However, a significant inter-individual variation in the levels of DNA adducts for apparently similar occupational exposure levels has been found. Thus, we have evaluated the role of genetic susceptibilities and different dietary intakes in influencing adduct formation. Our findings suggest the involvement of XPD, XRCC1 and XRCC3 genes in the repair of aromatic DNA adducts and the involvement of XRCC3 gene in teh repair of endogenous adducts. Our study supports also the protective effects of frequent consumption of fresh fruit and vegetables against aduct production.


    1376/2523

    Tytuł oryginału: Biomarkers in human disease states.
    Autorzy: Anderson Diana
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.69-81, tab., bibliogr. 23 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • onkologia
  • endokrynologia
  • hematologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Oncogenes are involved with the regulation of cellular proliferation and thus could be important in the development of disease states. The ras genes encode a protein of 189 amino acids of molecular weight 21kDa, designated as p21, and are in all eukaryotic cells contained on the inner surface of the plasma membrane. Ras p21 proteins were measured in plasma from lung cancer patients and patients with chronic obstructive pulmonary disease (COPD). Proteins were separated by gel electrophoresis, transferred to a nitrocellulose membrane by Western blotting and detected by chemiluminescence. A monoclonal pan-ras antibody was used as the primary antibody. Optical densities of the peak area of the protein bands were calculated and values which were two standard deviations above negative control means were considered positive. Many of the cancer patients and some of the COPD patients gave positive responses. Thus an increase in ras oncoproteins could be a biomarker for cancer or the disease state in general, but it cannot be ruled out that it is a biomarker for exposure since many of the individuals examined were smokers. The single cell gel electrophoresis (Comet) assay was used in lymphocytes from patients with diabetes and thalassemia. Brieflyy this assay conducted under alkaline conditions detects single strand breaks and alkali-labile sites by measuring the migration of denatured fragments within an agarose gel subjected to electrophoresis. When diabetes insulin-dependent and non-insulin-dependent ...


    1377/2523

    Tytuł oryginału: Microsatellite instability and gastrointestinal carcinoma: a never-ending story.
    Autorzy: Stachura Jerzy, Popiela Tadeusz, Czopek Jacek, Zazula Monika, Rudzki Zbigniew, Okoń Krzysztof, Kulig Jan, Białas Magdalena, Kołodziejczyk Piotr, Sińczak Anna, Papla Bolesław
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.83-93, il., bibliogr. 39 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We briefly review the current status of the research on the microsatellite status of colorectal and gastric carcinomas basing on the literature and our own studies. Investigation of microsatellite instability (MSI) is possible in archival material, and may by applied to analysis of relatively large retrospective series of cases. A specific profile of MSI-H (high) colorectal carcinomas, including right-sided location, mucinous an dsolid histology, and predominance of high-grade cases is a constant finding regardless of the geographical origin of the studied population, despide the fact that other aspects of colorectal cancer pathology differ markedly among various ethnic groups. The MSI-H tumors present several several intuively associated with bad prognosis, including the highest Ki67 proliferative fraction, but paradoxically may be associated with a more favorable outcome than MSS (stable) or MSI-L (low) cancers. The distinct status of the MSI-L colorectal cancers ("mild mutator pathway") is still unclear, but some reports, including our study, suggest that this group may present specific biologic features not necessarily placing it among MSS and MSI-H tumors. In gastric carcinoma the better prognosis linked to the MSI status emerges more and more firmly from the plethora of conflicting data. MSI-L gastric carcinomas may contain disproportionally high percentage of EBV-positive cases. The comparative aspect of the microsatellite research suffers from lack of widely acccepted standardized procedures aimed at detection of MSI, and from inconsistency in defining the MSS, MSI-L and MSI-H phenotypes among various authors.


    1378/2523

    Tytuł oryginału: Assessment of biomarkers of the immunomodulatory effects of asbestos in asbestos cement plant workers.
    Autorzy: Tulinska Jana, Dusinska Maria, Jahnova Eva, Liskova Aurelia, Kuricova Miroslava, Weissova Silvia, Horvathova Mira, Wsolova Ladislava, Machata Miroslaw, Kyrtopoulos Soterios A., Fuortes Laurence
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.95-101, il. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Immune parameters were examined in 61 workers exposed to asbestos fibres for an average of 23 years as well as in 46 town and 21 in-factory unexposed controls. Humoral immunity was evaluated by levels of immunoglobulins, concentrations of interleukins and soluble adhesion molecules. Cellular immunity was determined by phenotypic analysis of peripheral blood leukocytes (CD3, HLA DR, CD4, CD8, CD16+56, CD19), expression of adhesion molecules on leukocytes and activation markers on eosinophils. Immune function assays - proliferative response of lymphocytes and phagocytic activity of leukocytes were evaluated in exposed and unexposed populations. Using multifactorial analysis of variance we found significantly increased levels of immunoglobulin E, concentrations of IL-6 and soluble adhesion molecule ICAM-1 in asbestos exposed workers. Expression of adhesion molecule CD62L (L-selectin) on monocytes and granulocytes was significantly higher in explosed workers. Moreover CD69 and CD66b markers on eosinophils were significantly increased among people exposed to asbestos. Immune function assays showed a significant decrease in proliferative response of lymphocytes stimulated by T-cell mitogen PHA in the exposed group. Proliferation of lymphocytes stimulated through T-cell receptors, T-dependent B-cell response an memory cell function did not differ between exposed workers and controls. Spearman correlation analysis revealed decreasing proliferative response of T and B-lymphocytes in the exposed population with ...


    1379/2523

    Tytuł oryginału: Ferric reducing ability of plasma (FRAP) as antioxidant parameter in relation to endotheline-1 (ET-1) and tumor necrosis factor - alpha (TNF-alpha) in patients after myocardial infarction.
    Autorzy: Stępniewski Marek, Kitliński Marek, Pietrzycka Agata, Nessler Jadwiga, Pukal Małgorzata, Zielińska Ewa
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.103-106, il., bibliogr. 14 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska


    1380/2523

    Tytuł oryginału: Chlamydia pneumoniae in cerebrospinal fluid from patients with Alzheimer's disease and in atherosclerotic plaques.
    Autorzy: Jaremko Małgorzata, Paradowski Bogusław, Leszek Jerzy, Skóra Jan, Dobosz Tadeusz
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.107-113, il., tab., bibliogr. 32 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Chlamydia pneumoniae causes a range of the respiratory tract diseases in human and according to references has been associated with other clinical manifestations, including Alzheimer's disease, atherosclerosis, asthma and multiple sclerosis. The aim of this study were to determine the presence of C. pneumoniae DNA in atherosclerotic plaques and in cerebrospinal fluids of patients with Alzheimer disease. Bacterial DNA were preparated using the Chelex method and were screened by nested PCR reaction for fragment of the 16 S rRNA gene. The primers pairs HL-1, HR-1, and HM-1, HR-1 producing the 437-bp and 229-bp products, respectively. We showed the presence of C. pneumoniae DNA in 40 p.c. of cerebrospinal fluids and in 31 p.c. of atherosclerotic plaques. In conclusion, nested PCR detection of the fragment of bacterial 16 S rRNA gene is suitable technique to evidence of C. pneumoniae in human tissues.


    1381/2523

    Tytuł oryginału: Monitoring of genotoxic risk in industrial areas with an example Rużomberok papermill and factory.
    Autorzy: Micieta Karol, Murin Gustav, Kunova Katarina, Halasova Erika, Bukovska Eva
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.115-121, tab., bibliogr. 18 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • badanie porównawcze
  • praca epidemiologiczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objectives: To compare sensitivity of plant cell bioindication assay with human cell screening method on the example of heavy polluted area around papermill plant. Design: Two-year screening of bioindication effect at cytogenitc level of plant as well as human cells by regular sampling from three sites near the source of pollution and one control site. Setting: City Rużomberok is one of 12 air polluted areas in Slovakia, that according the Ministry of the Environment's of Slovak Republic needs special air protection. And this aim, consequently, needs serious screening of the impact of emission produced on living cells. Main outcome measure: Frequency of aborted/altered pollen grains and chromosomal aberations in peripheral lymphocytes in blood samples of children living in neighbourhoods of papermill plant. Results: From the 12 plant species analysed, significant difference from the control samples were found in frequency and occurrence of abortive an danomalous microspores and pollen grains among 9 species in year 1999 and 8 species in year 2000. They were: Pinus sylvestris L., Robinia pseudoacacia L., Corylus avellana L., Linaria vulgaris Mill., Melilotus albus Medik., Trifolium pratense L., Calystegia sepium R.Br., Chelidonium majus L., Cichorium intybus L. In the Pinus sylvestris L. samples we observed an increased amount of anomalous (unreducted, 2n, 4n) pollen grains, which represent mutagenity at the genome level. Spontaneous level of chromosomal aberrations in peripheral lymphocytes of children ...


    1382/2523

    Tytuł oryginału: Emerging concepts of genetic epidemiology.
    Autorzy: Pietrzyk Jacek J.
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.129-137, bibliogr. 46 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: The paper describes the scope and the primary objectives of genetic epidemiology. A synthesis of main methodological tools, including ascertainment strategies, heritability, segregation and linkage analyses is presented. The bases of molecular diagnosis of disease susceptibility genes by means of positional cloning and gene candidate approach are briefly described. The paper is closed by a short overview of genetic epidemiology development in Poland.


    1383/2523

    Tytuł oryginału: Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric mucosa and risk of gastro-duodenal ulcerations in men.
    Autorzy: Bielański Władysław, Konturek Stanisław J., Płonka Małgorzata, Cześnikiewicz Marta, Penar Agnieszka, Jędrychowski Wiesław
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.139-162, il., bibliogr. 59 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAID) are the most common pathogens in the stomach, but their interaction on gastro-duodenal mucosa has been little studied. Hp infection in humans does not interfere with NSAID-induced gastric ulcer healing by omeprazole, therefore, there is no rationale to eradicate the germ under these conditions. Hp infection induces COX-2 expression resulting in excessive biosynthesis of gastroprotective prostaglandin (PG), which should in turn counteract NSAID-induced gastropathy and contribute to healing of existing ulcers. Some investigators claim that Hp infection acts synergistically with NSAID on ulcergenesis and propose that Hp should be eradicated, particularly at the onset of long-term NSAID therapy but this is the subject of controversy. Material and methods: Our studies on 6515 dyspeptic patients undergoing upper endoscopy and 13C-urea breath test (UBT) revealed that about 70 p.c. of these patients are Hp positive and 31 p.c. of them develop gastro-duodenal ulcers. Of these ulcers, 66 p.c. were Hp positive non NSAID users, 3 p.c. were Hp negative and NSAID users, 8 p.c. were both Hp positive and NSAID users, while 23 p.c. ulcers were both Hp and NSAID negative. An evidence was obtained for negative interaction between Hp infection and NSADI on risk of gastro-duodenal ulcers suggesting that Hp may attenuate the peptic ulcerogenesis. Conclusions: Our results support the concept that 1) the interaction between Hp infection ...


    1384/2523

    Tytuł oryginału: Predictive assay for adverse health outcomes in molecular epidemiology.
    Autorzy: Cebulska-Wasilewska Antonina
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.163-175, il., tab., bibliogr. 18 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: There is continuously increasing concern about exposure of individuals to hazardous chemicals or physical agents and the possible resultant effects on human health. Chromosome aberrations as structural or numerical chromosome changes, resulting from direct DNA breakage or from inhibition of DNA repair or synthesis, measured in peripheral blood lymphocytes have been used in occupational health surveillance programs in order to assess genotoxic risks. The concept for this biomarker assumes that the extent of genetic damage in peripheral lymphocytes reflects similar events in the precursor cells for carcinogenic processes. In the first cellular division the frequencies of unstable chromosome aberrations (dicentrics, rings fragments) and stable chromosome aberration - translocations (analyzed with FISH technique) are often studied for the purpose of retrospective biological dosimetry, in the second cellular division sister chromatid exchanges and high frequency cells. Discussed here results of cytogenetic damage detected in a monitoring studies have shown the association with adverse health outcome and the influence of confounding factors related to the life style. Susceptibility to the activity of environmental agent was evaluated in studies on variation between responses to challenging dose of UV or X-rays followed by the evaluation of the repair capacity of the damage induced by a challenging dose. The induced and residual damage was detected with the use of the DNA damage analysis by single cell gel electrophoresis ...


    1385/2523

    Tytuł oryginału: Research on genetic aspects of obesity in South Poland.
    Autorzy: Wybrańska Iwona, Malczewska-Malec Małgorzata, Kieć-Wilk Beata, Jabrocka Agata, Zdzienicka Anna, Niedbał Sylwia, Gruca Anna, Dembińska-Kieć Aldona
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.181-193, tab., bibliogr. 52 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Obesity is multi-factorial disease with both genetic and environmental component. The aim of our study was to determine the frequency distribution of selected "obesity candidate gene" polymorphism in families from South Poland and to assess the influence of studied polymorphisms, with phenotype, and biochemical parameters. The study was carried out in group of 122 patients from 40 families with genetically trait of obesity. The following variants have been analysed: monogenic obesity mutation: leptin (OB) and PPARç-2 and common polymorphisms: beta2AR, beta3AR, UCPP-1, DRD2, LPL-H, LPL-P, apo CIII, TNF-ŕ, PPAR-ç-2, apo E, FABP-1 and MCR-4. Any monogenic obesity mutation was detected in our study group. The single gene polymorphisms influenced the lipid and carbohydrate metabolism parameters. The DRD2 C allele had the highest occurrence (77,3 p.c.) in our study group. The coexistence of more than one susceptible allele was powerful determinant of development obesity. Our results confirm significant relationship between gene-environment and gene-gene interaction in obesity phenotype.


    1386/2523

    Tytuł oryginału: Lipid biomarkers in nutritional epidemiology.
    Autorzy: Charzewska Jadwiga, Chwojnowska Zofia
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.195-202, tab., bibliogr. 10 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Nutrition epidemiology has progressed during last decades and provided unprecedented information on the relation between diet and health. In spite of these facts still many questions remain. Where are the gaps? There are several areas which demand attention: improvement of dietary assessment methods, measuring errors of methods, exploring gene-diet interaction or even better planning a study design. However, among above, nutrition epidemiologist has as one of the primary interests, to investigate objective measures of biochemical indicators of dietary intake, so called biologic markers of energy and particular nutrients intake. In theory, observed nutrient intakes should at least potentially be related to the amount of proper biochemical markers. However, it cannot be assumed that there is a close or simple relationship. There are various complicating factors in the relationship and for that reason a new biochemical approach is needed. The example of fatty acids as biomarkers for fat consumption and lipid status in serum of 39 men will be discussed. Summing up, conclude that major differences in fatty acids composition of adipose tissue are not explained by all differences in fatty acids intake with diet. Other factors such as unmeasured dietary variables or genetic influences can be responsible for the observed relationship.


    1387/2523

    Tytuł oryginału: Selenium in Polish population. Nutritional status, dietary daily intake, and clinical aspects.
    Autorzy: Wasowicz Wojciech
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.203-211, il., tab., bibliogr. 43 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The concentration of selenium (Se) in human organism varies widely between geographical areas depending on its content in soil and plants and dietary Se intake, bioavailability and retention, mineral interactions and other factors. Lack of knowledge of the reference values of Se parameters in healthy individuals may prevent the diagnosis of abnormal states or the identification of population group that are risk of diseases owing to Se deficiency. The study includes healthy inhabitants of different regions of Poland; pregnant women, children from 0 to 15 years of age and adults. Systematic determinations allow us to observe changes of the concentration of Se in time, which may be significant for developing preventive action. The results obtained confirm our thesis that Se concentration in the blood of the inhabitants of Poland depends on the region of the country. In recent years, in a considerable number of Polish inhabitants, the concentration of Se in blood plasma has been relatively low - about 50-55 ćg/l, and the calculated daily dietary intake about 30-40 ćg/day. The low levels of the elements in the blood and urine are probably due to its deficiency in the diet.


    1388/2523

    Tytuł oryginału: Immunological markers of susceptibility in respiratory epidemiology.
    Autorzy: Zejda Jan E., Złotkowska Renata
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.243-252, il., tab., bibliog. 50 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • pediatria
  • toksykologia
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.


    1389/2523

    Tytuł oryginału: Placental antioxidant system in relation to environmental pollution expressed as trace elements concentrations.
    Autorzy: Stępniewski Marek, Pietrzycka Agata, Zamorska Lucyna, Zadrożna Monika, Kitliński Marek, Solarska Katarzyna, Batko Bogdan
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.253-260, il., tab., bibliogr. 4 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • in vitro


    1390/2523

    Tytuł oryginału: Reimplantation of ureters into the colon cap during sigmoidocystoplasty for treatment of vesicoureteric reflux associated with neurogenic bladder: long-term outcome.
    Autorzy: Yamataka Atsuyuki, Wang Kun, Ohshiro Kiyohiko, Lane Geoffrey J., Gamal Alsagheer, Miyano Takeshi
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.6-9, il., bibliogr. 6 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The authors present the long-term outcome of reimplantation of ureters into the colon cap (RUCC) during sigmoidocystoplasty (SCP) for the treatment of vesicoureteric reflux (VUR) associated with neurogenic bladder. A retrospective review of thirteen patients with VUR associated with neurogenic bladder (24 ureters) that had RUCC during SCP at our institution was dne. Mean age at surgery was 10.9 yrs (range: 2.1 - 16.4 yrs). Mean follow-up period is 11.5 yrs (range: 5.3 - 16.3 yrs). Severrity of VUR was grade V in 4/24 ureters, grade IV in 12/24, grade III in 4/24, and grade II in 4/24. RUCC was performed into the taenia coli located in the anterior wall of the colon cap in 11/13 patients, and into the posterior wall of the colon cap in 2/13. The average length of the submucosal tunnel created during reimplantation was 23.0 mm. Excisional tapering of the ureter was performed in six ureters, and folding of the ureter in three. Postoperataive complications encountered were vesicoureteric junction stenosis, vesical calculi, and sponttaneous bladder perforation. Renal scarring that progressed to chronic renal faailure developed post-SCP in two patients. There has been no recurrence of VUR. RUCC during SCP is successful and should be actively considered when there is VUR associated with neurogenic bladder and the bladder wall is unsuitable for conventional reimplantation.


    1391/2523

    Tytuł oryginału: Comparison of extravesical and intravesical methods of surgical treatment of primary vesicoureteral reflux in children.
    Autorzy: Kudela Grzegorz, Koszutski Tomasz, Bohosiewicz Janusz, Skrabski Robert
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.10-13, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • urologia
  • chirurgia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study is the assessment of the results of surgical treatment of vesicoureteral reflux using the extravesical Politano-Leadbetter and Cohen methods and intravesical modified Lich-Gregoir method and analysis of postoperative complications and necessary hospitalizations. From January 1995 through February 2000, 111 children with primary reflux were operated on. The Lich-Gregoir procedure was performed on 36 children (50 ureters), the Poloitano-Leadbetter procedure, in 35 children (41 ureters) and the Cohen procedure in 40 children (80 ureters). The extravesical operation was done slightly faster than the intravaesical methods (p 0.05). Perioperative complications were found in 18.8 p.c. children operated by intravesical methods and in 2.8 p.c. children after an extravesical operation (p 0.05). The hospitalization time after unilateral detrusorrhaphy was 6.4 ń 1.3 days and 10.7 ń 2.5 days after the unilateral Politano-Leadbetter procedure (p 0.05). The hospitalization duration after bilateral detrusorrhaphy was 5.6 ń 1.6 days adn 11 ń 2.6 days after the bilateral Cohen procedure (p 0.05). Reflux grade III and IV completely resolved in 100 p.c. of cases treated by intravaesical procedures and in 95 p.c. after extravesical procedures (p 0.05). The results of antireflux procedures are good in all groups; none of the surgical methods was found to be significantly more effective than the others. The number of complications and necessary hospitalizations after the Lich-Gregoir procedure was lower.


    1392/2523

    Tytuł oryginału: Quick correction of hemostasis by recombinant activated Factor VII as rescue therapy in pediatric surgery - our own experience.
    Autorzy: Markiewicz Małgorzata, Kaliciński Piotr, Kamiński Andrzej, Ismail Hor, Drewniak Tomasz
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.14-17, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Severe bleeding in surgery is a serious problem, espcially in children. The small total body volume of circulating blood makes treatment of patients with massive blood loss very difficult. Loss of what for an adult is a small amount of blood easily leads to shock in children. It is very important to reduce blood loss and to treat hemorrhage with the most effective drugs. Highly invasive surgery, especially reseaction of the liver, kidney etc, laparotomies after severe multiorgan trauma can always cause blood loos and hemorrhage, which, if unchecked in time, can be life-threatening for patients because of blood loss shock or post-transfusion problems (DIC, coagulopathy). The risk of deaths is especially high in patients with congenital or acquired coagulopathy before surgery. It is well known that survival, postoperative complications, as well as post-operataive hospital stay are dependent on perioperative blood loss and the volume of transfused blood and blood perparations. All of the above make it very important to reduce blood loss during surgery. Fecombinant activated Factor VII (NovoSeven, NovoNOrdisk) is very useful in treating patients with various congential hemostatic diseases. rFVIIa has been used in recent years for the treatment of patients with severe bleeding in other clinical situations. In this article we present our expereience with treating such patients. Between 1997-2001 we used rFVIIa in 16 different clinical situations as rescue therapy ot obtain immediate coagulation correction. In all cases full clinical correction was achieved. INR before administration of rFVIIa ranged between 10 and 2.28; after administration, 0.98-2.51 (mean...


    1393/2523

    Tytuł oryginału: Changeable views on the treatment of gastroschisis.
    Autorzy: Chilarski Andrzej, Bułhak-Guz Hanna, Grochulska-Cerska Hanna
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.18-22, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The mortality rate associated wtih gastroschisis has declined markedly over the last two decades due to many factors such as prenatal diagnosis, neonatal intensive care, improved surigcal techinique, total parenteral nutrition. The aim of this study was to analyze clinical material comprising patients with gastroschisis in its prenatal and postanatal aspects. Out of 36 fetuses, the diagnosis of gastroschisis was established prenatally in 27 (75 p.c.). There are two conditions found on US examination that may imply the need for prenatal intervention: severe oligohydramnion and indications for amnioinfusion and signs of closing gastroschisis, an indication for emergency cesarean section. As far as postanatal tretment is concerned, there are three options: - simple reduction of the eviscerated bowel (5 patients in our series), - open reduction, with ensuing fascial closure (9 patients in our series), - multistage procedure (22 patients in our series). There is some confusion in the literature as regards the choice of the appropriate option. The ultimate goal is to achieve full fascial closure. In order to complete this in one step and to avoid compartemnt syndrome, some conditions must be fulfilled: - the eviscerated bowel must be relatively unchanged, with no ischemia nor necrosis, - the with of abdominal defect must enable the reduction, - complicated gastroschisis (e. g. with atresia, perforation) has to be excluded from this procedure, - intraabdominal pressure should be monitored intra- and postoperatratively. We have been using a system of monitoring of intraabdominal pressure based upon measurement of intrabladder pressure by means of a simple mobile device. Tegmentum has been used in all of the newborns that were evaluated as candidates for a multistage procedure (22). It is based on a polyethylene mesh covered with a polyurethane layer.


    1394/2523

    Tytuł oryginału: Bilateral Wilms tumor. Changes in management over time. Own experience.
    Autorzy: Dembowska Bożena, Perek Danuta, Rutynowska Olga, Brożyna Agnieszka, Gastoł Piotr, Dura Wiesław T.
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.23-28, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • nefrologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study was to assess treatment methods and survival of children with bilateral Wilms' tumor (BTW) treated over a 34-year period in one department. The medical records of 26 patients with BWT treated between 1966 - 2000 were reviewed with particular emphasis on treatment and histology. The patients were divided into 2 groups according to the treatment applied. Group I consisted of 9 patients treated between 1966 - 1982. Treatment was based on initial surgery. Group II consisted of 17 patients treated between 1983 - 2000. All of them received preoperataive chemotherapy followed by kidney sparing operations when possible and/or irradiation. Among 26 patients, 25 presented with synchronous and one with anachronous Wilms' tumor. Three patients were diagnosed with anaplastic tumors, 2 had blastemal predominance, and the rest were of standard histology. In Group I, different kinds of primary surgical procedures were performed in 4 patiens (unilateral nephrectomy, heminephrectomy) followed by radiotherapy and chemotherapy with Actinomycin D (ACTD). Four patients started treatment with chemotherapy - 1 course of ACTD and Vincristine (VCR) and radiotherapy 12 cGy to the kidney with the less advance tumor followed by heminephrectomy in 1 pt, nephrectomy 1 pt, and 2 bilateral nephrectomies. None of the patients in this group survived, 4 died of treatment complications, the remaining from the diseases. In Group II all 17 patients received preoperative chemotherapy consisting of ACTD, VCR. In the case of poor response other drugs such as Doxorubicin, Carboplatin, Toposide, Ifosfamide and Dacarbazine were implemented...


    1395/2523

    Tytuł oryginału: Is outcome of children with acute appendicitis dependent on preoperative antibiotics prophylaxis and type of surgical approach?
    Autorzy: Niedzielski Jerzy, Przewratil Przemysław
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.29-32, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Antibiotics are widely used in preoperative profilaxis in order to decrease the incidence of postoperative complications in patients with acute appendicitis (AA). The aim of this study was to evaluate the possible effect of single preoperative dose of Cefotaxime as well as the type of surgical approach on outcome of children with AA. The 297 children underwent appendectomy in two periods of time: 1990 - 1992 (I) and 1998 - 1999 (II). In period I antibiotics were administered intra- or postop and appendectomy was performed via lower longitudinal incision with opening of the sheath of the right rectus abdominis. In period II antibiotic was administered preoperatively as a routine and appendectomy was done through a transverse right lower quadrant incision. Fifty children of period I (26.9 p.c.) presented with advanced stages of AA comparing with 22 patients (19.8 p.c.) of period II. Postop complications were observed respectively in 7 (3.8 p.c. - I) and 4 (3.6 p.c. - II) instances. Authors conclude that both preoperative antibiotics prophylaxis and different surgical approach have no significant impact on final outcome of children with AA, exept for definitely better cosmetic results after appendectomies performed trough transverse incision (period II).


    1396/2523

    Tytuł oryginału: Experience with allografts and silver sulfadiazine in burn wound treatment.
    Autorzy: Szmytkowska Krystyna
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.33-35, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • transplantologia
  • traumatologia i ortopedia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Two groups of children treated for burns at our department are presented in the paper. In one of the groups glycerol-preserved human skin was used for local treatment, the other group was treated with silver sulphadiazine. Two years after wound healing scar assessment was performed with the help of a special formula. A retrospective documentation analysis was performed to assess the influence of local therapy type on the duration of hospital stay. The results are encouraging, clearly showing a better scar quality and higher patients comfort achieved with allograft treatment.


    1397/2523

    Tytuł oryginału: Osteomyelitis of the pelvis.
    Autorzy: Okłot Krzysztof, Królicka Jolanta
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.36-39, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: The authors present two cases of ilium osteomyelitis in children. The patients were treated at the Trauma and Orthopedic Department of the Niekłańska Street District Children's Hospital in Warsaw between 1997 - 1999. There were some diagnostic difficulties at the beginning of the illness in both children. In addition to antibiotic therapy both children were treated with surgical drainage of the large pus accumulations, which were situated around the iliac wing. Fast recovery occurred after surgical intervention. Long-term follow-up shows full recovery in the older child and some secondary pelvis deformation because of Y growth plate and sacro-iliac joint destruction in the newborn. There was no recurrence of osteomyelitis in either patient.


    1398/2523

    Tytuł oryginału: Neonatal invagination: cause of secondary ileal atresia.
    Autorzy: Vrsansky Pavol, Al Faour A., Dabbagh H., Vrsansky D., Koulouris E.
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.40-42, il., bibliogr. 4 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć męska

    Streszczenie angielskie: The authors refer an observation of neonatal intussusceptions at 36th day of life, which resulted in ileum attresia in a newborn, which had proved patency of teh gastro-intestinal tract with repeated stools before an accident. The case directly confirms etiology of intestinal accident (intussusceptions) with necrosis in atresia.


    1399/2523

    Tytuł oryginału: Acquired gastric-outlet obstruction in a 2-year-old child with peptic ulcer disease.
    Autorzy: Kirejczyk Jan Krzysztof, Dębek Wojciech, Lenkiewicz Tomasz
    Źródło: Surg. Childh. Int. 2002: 10 (1) s.43-46, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • chirurgia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • płeć żeńska

    Streszczenie angielskie: A case of a child with acquired pyloric obstruction in the course of peptic ulcer disease is presented. Medical treatment was unsuccaessful. Pyloroplasty and gastrojejunostomy were performed. One year after the operation the child takes solid food and has resumed normal growth. Various aspects of etiology and management are discussed.


    1400/2523

    Tytuł oryginału: Immune biomarkers in salt miners exposed to salt dust, diesel exhaust and NOx.
    Autorzy: Back‚ Eva, Lotz Gabriele, Tittelbach Ulrike, Plitzko Sabine, Gierke Erhardt, Thim Carmen, Schneider Wolfram Dietmar
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.261-267, tab., bibliogr. 14 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Selected immune parametrers in the blood of salt miners were analysed to calculate whether there is an effect of salt dust, diesel exhaust, NOx and smoking on these biomarkers. Analysis of soluble markers in the serum (s-ICAM, MCP-1, CC16, Immunoglobulins) was done in 290 miners. Analysis of cells (complete blood count, lymphocyte substes) was performed in 143 subjects. Significant differents between non-smokers and smokers were found for the number of all leukocyte types (p 0.012) and also for the serum parameters CC16 (p = 0.021), s-ICAM (p = 0.00), IgE (p = 0.039), IgM (p = 0.027). Regression analysis indicates an effect of the exposure in the salt mine, number of lymphocytes, T-cells and activated T-cells seems to be higher with increasing exposure (e.g. results for respirable dust p = 0.0099, p = 0.011). These results suggest, that the analysis of lymphocytes and their subsets can coplete other investigations (e.g. lung function analysis) to monitor exposure response relationship in occupational studies investigating the effect of inhaled substances.


    1401/2523

    Tytuł oryginału: Circulating micrometastatic cells in patients with gastric cancer.
    Autorzy: Zembala Marek, Pituch-Noworolska Anna, Baj-Krzyworzeka Monika, Baran Jarosław, Drabik Grażyna, Mieżyński Witold, Popiela Tadeusz, Czupryna Antoni, Szczepanik Antoni, Stachura Jerzy, Urbańczyk Katarzyna
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.273-280, il., tab., bibliogr. 25 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1402/2523

    Tytuł oryginału: Risk factors for nonmelanoma skin cancer in Prievidza district, Slovakia.
    Autorzy: Pesch Beate, Unfried Klaus, Jakubis Pavel, Jakubis Marian, Keegan Thomas, Miskovic Peter, Nieuwenhuijsen Mark, Hergem”ller Andre, Rabstein Sylvia, Ranft Ulrich
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.281-294, il., tab., bibliogr. 31 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The nonmelanoma skin cancer (NMSC) risk associated with the combustion of arsenic-rich coal to generate power in the district of Prievidza, Slovakia, was investigated as part of a European Union-funded project, EXPosure to ArSenic and CANcer in Central and Eastern Europe (EXPASCAN). We conducted a population-based case-control study with 264 cases and 286 controls. A questionnaire was used to obtain exposure and confounder information. Arsenic was measured in urine, soil, house and dust. DNA was extracted from buccal swaps to analyze sequence variations in the repair gene ERCC2 among other candidate genes. Historical arsenic pollution was modeled, and current arsenic exposure in environmental and biological specimen - although much lower than in the past - still shows a significant variation by distance to the power plant. Exposure of the study subjects to environmental arsenic was assessed with the residential hitory and annual arsenic emissions (Asres), further with nutritional habits taking additionally into account the consumption of home-grown food (Asnut). High exposure to environmental arsenic was associated with an excess risk for both Asres (odds ratio (OR) 1.90, 95 p.c. confidence interval (CI) 1.38-2.62) and Asnut (OR 1.83, 95 p.c. CI 0.98-3.43). Among other potential risk factors, skin characteristics and DNA repair were analyzed in more detail. Blonde or red hair was associated with an excess risk (oR 22.64, 95 p.c. CI 1.34-5.19). There were no overall effects of the sequence variations ...


    1403/2523

    Tytuł oryginału: Risk assessment and human exposure to endocrine disrupters.
    Autorzy: Bencko Vladimir
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.295-305, il., tab., bibliogr. 22 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ochrona środowiska
  • onkologia
  • endokrynologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Human exposure to endocrine disrupters (EDs) is widespread and is considered to pose a growing threat to human health. Recent advances in molecular and genetic research and better understanding of mechanisms of blastic cell transformation have led to efforts to improve cancer risk assessment for populations exposed to this family of xenobiotics. In risk assessment, low dose extrapolation of cancer incidence data from experimental animals and epidemiology studies has been largely on models assuming linear correlation at low doses, despite existence of evidence showing othervise. Another weakness of ED risk assessment is poor exposure data in ecological studies. Those are frequently rough estimates derived from contaminated items of local food basket surveys. Polyhalogenated hydrocarbons and arsenic are treated as examples. These is growing sense of urgency to develop a biologically based dose response model of cancer risk, integrating emerging data from molecular biology epidemiology to provide more realistic data for risk assessors, public health managers and environmental issues administrators.


    1404/2523

    Tytuł oryginału: Biomarkers of exposure and effect in an investigation of the influence of harmful occupational pollutants on the respiratory system mediated by the disturbances of antioxidant status of welders.
    Autorzy: Kolarzyk Emilia, Stępniewski Marek, Pietrzycka Agata, Kitlinski Marek, Helbin Jadwiga, Zagrodzki Paweł
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.307-315, il., tab., bibliogr. 20 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: A hypotehsis of existing cause-effect relationship between the disturbances of antioxidative balance, as a biomarker of occupational exposition to nitrogen oxides and ozone, concentration of selected trace elements in blood serum and hair, taken as biomarkers of exposition, and impairment of the respiratory system, regarded as a biomarker of effect has been tested on a representative goup of welders occupationally exposed to these pollutants. The subjects of the study were 94 welders aged 41.2 (+10.0) exposed in their workshops to nitric oxides and ozone in concentration exceeding TLV. As a control group served 115 workers, 40.8 (++10.2) years old, performing virtually the same tasks, except welding. It was found that in the group of welders concentrations of TAS, CT, SOD were lower compared to the controls. COPD and Small Airway Disease (SAD) in the welders groups was more frequent than in the controls (COPD:14.9 p.c. welders, 3.5 p.c controls; at risk of COPD 37.2 p.c. welders, 15.7 p.c controls; SAD:32 p.c. and 20 p.c respectively). From a wide array of trace elements in blood and their taken into account in principal components analysis (PCA), and mutual contributions analysis (MCA), only the relation of MEF50, Cu in blood serum and TAS were statistically valid. MCA revealed that asymmetrical interactions exist between TAS and Cu (ëCu-TAS = 97.2 p.c., ëTAS-Cu = 36.1), as well as between TAS and MEF50 (ëMEF50-TAS = 82.4 p.c., ëTAS-MEF50 = 23.9). The Concentration of copper in blood serum correlacted better with antioxidant status (TAS) than the content of this element in hair.


    1405/2523

    Tytuł oryginału: Molecular end-points in preventive medicine of chronic degenerative diseases. From animal models to humans.
    Autorzy: Izzotti Alberto
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.319-330, il., bibliogr. 20 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Molecular biology explores interactions between risk factors and organism deferences in healthy individual during the long laaatncy of chronic-degenerative disease. We developed experimental animal models to demonstrate the ability of this approach in predicting risk of developing diseases and to identify preventive measures. Cigarette smoke (CS) induces in 28 days only DNA adduct increases in respiratory, urinary and cardiovascular apparatus of exposed rats. Similar adducts were detected in the atherosclerotic aorta of human patients, their level being higher in GSTM1-null nonsmokers. CS also induces DNA adduct formation in the liver of transplacentally exposed foetuses. Multigene expression analysis by cDNA arrays revealed that foetus counteracts CS-related DNA alterations by decreasing cell cycle rate and inducing DNA repair activities, a defensive mechanism resulting in growth retardation. Light induces in 4 weeks molecular lesions in skin, including nucleotide modifications, increased cell replication rate and protooncogene expression. Related skin cancer ariase only 27-38 weeks later. In animal models, formation of CS-induced molecular alterations can be prevented by administrating chemopreventive drugs, thus demonstrating their efficacy and safety. A phase II chemopreventive trials performed in human smokers demonstrated the ability of N-acetyl-L-cystine to inhibit DNA adduct and 8-OH-dG formation in pulmonary alveolar marcophages. A frequent problem in similar studies is the availability of negligible ...


    1406/2523

    Tytuł oryginału: Screening the human expression library for protein interaction with vacuolating cytotoxin (VacA) of Helicobacter pylori.
    Autorzy: Wesołowska Aleksandra, Ostrowski Jerzy
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.331-337, il., bibliogr. 15 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Vacuolating cytotoxin (VacA) is the main virulence factor of Helicobacter pylori, a well-recignized pathogen that infects up to 50 p.c. of the world's human population. Infection with Helicobacter pylori is associated with both antral gastritis and duodenal ulcer and increases the risk of gastric adenocarcinoma. According to epidemiological data, the stage of the disease depends on the genetic diversity of vacA between the different strain of bacteria. In fact pathogenesis may depend on both bacterial and the human genotype. Specific protein interactions could constitute the molecular mechanism responsible for this correlation and therefore the human proteins binding to VacA were indentified. Using VacA as bait in a yeast two hybrid system the cDNA library representing the sequence expressed as mRNA in the tissue of gastric patient infected with Helicobacter pylori was screened. Results indicate that there is an interaction between the carboxy-terminal fragment of VacA with the subunit á of human trimeric protein G. With reference to the earlier stidies with several bacterial toxins that modify G proteins it is not unlikely that this interaction influences the Helicobacter pylori pathogenesis.


    1407/2523

    Tytuł oryginału: Occupational exposure to monochlorobenzene: biomarkers of effect do not confirm TWA = 350 mg/m3.
    Autorzy: Molodkina Nina N., Sorkina Nelli S., Tkacheva Tatiana A.
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.339-342, tab., bibliogr. 5 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia

    Typ dokumentu:
  • badanie porównawcze
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    1408/2523

    Tytuł oryginału: Intermediate endpoints in the molecular epidemiology of cancer.
    Autorzy: Bonassi Stefano
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.347-353, tab., bibliogr. 17 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Intermediate endpoints of cancer (IEC) are those events that can be used to antipicate the clinical diagnosis of the disease. An alteration or an increase over the background frequency of these biomarkers allows estimating the risk of cancer development, since they generally lie on the pathway leading from the initiation of the neoplastic process to the occurrence of invasive cancer. Given the key role in public health and the potential use of this information to predict the development of disease and to implement disease prevention programs a special consideration should be given to the validation process of intermediate endopoints. Among biomarkers considered as candidate IEC, good theoretical evidence and a number of epidemiological prospective studies supports the evidence that chromosome aberrations measured in lymphocytes of healthy individuals are predictive of cancer risk. Appying the figures estimated by these studies, the proportion of cancers that could be attributed to an increase in the frequency of chromosomal aberrations was evaluated to be 23-24 p.c. The estimation of cancer risk in astronauts after space missions was reported as an exmple of how this information can be in risk assessment.


    1409/2523

    Tytuł oryginału: Ethical issues in molecular epidemiology.
    Autorzy: Richter Elihu D., Peretz Tamar
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.355-368, il., tab., bibliogr. 24 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: New developments in Molecular Epidemiology make it possible to (1) identify groups at excess group risk for cancer from exposures to carcinogens; (2) identify individuals at special risk from genetic susceptibility (3) identify subgroups at special individual risks for adverse health effects from exposures to toxic agents; and (4) assess the role of interventions in reducing the risks for these effects (e.g. reduction in clastogenic changes as a maarker of nutritional modification of effects from exposure to ionizing radiation). They also hold the promise of providing information on specificity on dose-response relationships in medico-legal assessments for elligibility for compensation. The use of biomarkers in the assessment of the benefits of community-based interventions is especially promising. This paper presents case studies which exame some of the ethical questions arising from the emergence of molecular epidemiology. Will new data from molecular epidemiology promote or dilute new concepts of protection based on the precautionary principle? In occupational medicine, will biomarkers be used to identify new genetic sub castes whose members will be targeted for removal from the work environment, on grounds of cost-benefit? In population-cohorts, e.g. individuals with past high exposures to hazardous agents, does knowledge coming from use of biomarkers for early detection on early sings of potential risk in groups justify monitoring if there are no known benefits to the individual from early detection?...


    1410/2523

    Tytuł oryginału: Family history of disease (genetic risk) and illness behaviours in colon cancer patients.
    Autorzy: Tobiasz-Adamczyk Beata, Bajka Jadwiga, Brzyski Piotr
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.373-379, il., tab., bibliogr. 9 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the study was to assess the significance of family history of cancer risk on the development of coping strategies employed by colon cancer patients. in the analysed group of 321 colon cancer patients 131 (40.8 p.c.) reported family history of cancer. These patients were less likely than other patients to engage in behaviours that reduced the risk of occurring symptoms and in coping strategies with illness. They varied in their emotional responses to symptoms; a sense of fatalism and the feeling of resignation was declared in higher level (OR = 1.71, CI 0.93 - 3.17), similarly as the association between stress, stressful life events and the aetiology of their disease (OR = 1.62, CI 1.03 - 2.54). They also more frequently reported genetic determinants in the course of disease, felt less responsible (guility) for the onset of disease. Median time period from the onset of symptoms until seeking first medical consultation was higher in patients with family history of cancer.


    1411/2523

    Tytuł oryginału: Hyperinsulinemia as predictor and risk factor for unknown type 2 diabetes. Polish multicenter study on diabetes epidemiology (PMSDE), 1998-2000.
    Autorzy: Szybiński Zbigniew, Szurkowska Magdalena, Placzkiewicz Ewa, Szafraniec Krystyna
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.381-393, il., tab., bibliogr. 40 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Increasing diabetes prevalence requires new strategies for its prevention, early diagnosis and prompt treatment. Apart from glucose in OGTT insulin is considered a possible metabolic marker in early diagnosis of type 2 diabetes. The study was performed to determine in cross-sectional investigation plasm ainsulin concentrations in subjects with diffreent phases of glucose intolerance and to assess the clinical usefulness of insulinemia in identification of the individuals at risk and in early diagnosis of type 2 diabetes. Insulinemia in 2-h-OGTT in IGT, and fasting and 2-h-OGTT in UD have been identified in multiple analysis as the potential strong risk factors of IGT an dUD with the corresponding highest values of the risk coefficient. Therefore, determination of the plasma insulin concentration may be useful in early diagnosis of IGT and UD.


    1412/2523

    Tytuł oryginału: Influence of antihypertensive treatment with perindopril, pindolol or felodipin on plasma leptin concentration in patients with essential hypertension.
    Autorzy: Ficek J., Kokot F[ranciszek], Chudek J., Adamczak M., Ficek R., Więcek A.
    Źródło: Horm. Metab. Res. 2002: 34 (11/12) s.703-708, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 312,226

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Leptin - produced predominantly by adipocytes - is presumably also involved in pathogenesis of essential hypertension (EH). In the present study, we addressed the question whether and to what extent antihypertensive monotherapy does influence leptinemia in patients with mild or moderate EH. Forty-two EH patients were enrolled in this randomized, open-labeled study. In all subjects, plasma concentrations of leptin, insulin, glucose, cholesterol, triglicerides and creatinine were estimated twice - before and one month after initiation of monotherapy with perindopril, pindolol or felodipin, respectively. Plasma leptin concentration, in the afteron and midnight, was significantly higher in patients with esential hypertension than normotensive healthy subjects (p 0.01). Therapy with perindopril or felodipin did not influence the daily profile of leptinemia or insulinemia, respectively. However, pindolol monotherapy showed a marked (p 0.01) suppressive effect on the daily profile of leptinemia, but did not influence insulinemia. Conclusions: First, patients with essential hypertension are characterized by higher plasma leptin levels as compared with normotensive healthy subjects; second, suppressive effect of pindolol on leptinemia may be pathophysiological relevance in the course of weight gain during á-blocker therapy.


    1413/2523

    Tytuł oryginału: Chronic graft-versus-host disease and its management in children.
    Autorzy: Vossen J. M., Breedeveld L., Bakker J. D. J., Mertens B., Well-Sipman M. H. van
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (4) s.133-138, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Chronic graft-versus-host disease is sometimes a severe, disabling and long-lasting complication of allogeneic hematopoietic stem cell transplantation. Its frequency lies between 10 and 40 p.c. of pediatric graft recipients, depending on a number of risk factors. Such factors are the type, i.e. HLA-identical related or not, gender and age of the stem cell transplant donor, original diagnosis of the patient and, most importantly, the occurrence or not of a prior acute graft-versus-host disease. Chronic graft-versus-host disease manifests itself as a collagen vascular autoimmune disease. Its treatment consists of immuno-modulatory and antiinfections drugs, in addition to supportive care and psycho-social support. Medical treatment demands a tailor-made approach and careful and prolonged surveillance.


    1414/2523

    Tytuł oryginału: The value of postoperative radiotherapy of primary spinal cord glioma.
    Autorzy: Nowak-Sadzikowska Jadwiga, Gliński Bogdan
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (4) s.139-147, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Forty patients with spinal cord gliomas, irradiated postoperatively between 1976 and 1994 at the Department of Radiation Oncology of Maria Skłodowska-Curie Memorial Centre in Kraków, were retrospectively reviewed. Twenty seven (67 p.c.) patients were classified as those with ependymomas, and 13 (33 p.c.) with astrocytomas. Thirty six patients were irradiated because of non radical excision, in 4 cases indication for radiotherapy was high grade histology. The overall actuarial survival rates at 5 and 10-years were 74 p.c. and 71 p.c., respectively. The 10-year relapse free survival was 69 p.c. Multivariate analysis showed that only age, histology and neurological function were correlated with survival time. Patients under 30 years of age, with ependymoma, and with very good, good or moderate neurological function carried the best prognosis.


    1415/2523

    Tytuł oryginału: Cancer gene therapy - state-of-the-art.
    Autorzy: Wysocki Piotr J., Mackiewicz-Wysocka Małgorzata, Mackiewicz Andrzej
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (4) s.149-155, bibliogr. 40 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: A number of gene therapy clinical trials are being carried out the world over. Gene therapy is being applied in (I) cancer diseases, involving the largest number of patients, (II) monogenic diseases, (III) infectious diseases, (IV) vascular diseases, (V) autoimmune diseases and others. In the last decade, several strategies of cancer gene therapy have emerged due to a rapid development of gene delivery systems, both viral (recombinant retroviruses, adenoviruses, AAVs, herpes viruses) aand non-viral (liposomes, gene guns, electroporation). To date four main strategies of cancer gene therapy have been evaluated in clinical trials: (I) immunogene therapy, (II) suicide gene therapy, (III) antiangiogenic gene therapy, (IV) and administration of tumour suppressor genes. These strategies mostly involve: malignant melanoma, prostate cancer, renal cell cancer, colon cancer, breast and ovarian cancers, lung cancers, neoplastic diseases of the blood and brain tumours. At the Department of Cancer Immunology at the GreatPoland Cancer Center Gene Modified Tumour Vaccine has been tested in malignant melanoma patients for more than six years. Due to encouraging results from phase I and II of clinical trials a phase III was designed and will be started in 2003.


    1416/2523

    Tytuł oryginału: Hormonal therapy combined with radiotherapy in locally advanced prostate cancer.
    Autorzy: Milecki Piotr, Kwias Zbigniew
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (4) s.157-163, bibliogr. 30 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia
  • radiologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie angielskie: At present radiation therapy and radical prostatectomy are considered to be the treatment of choice for clinical T1-T2 prostate cancer. In a more advanced stage of the disease (T3) 10-year overall survival is observed in approximately 40 p.c. of patients treated with conventional radiotherapy. So far only a few methods for improving the efficacy of radiotherapy have been introduced. One of them is a three-dimensional conformal radiotherapy with 3 dimensional treatment planning. These novel methods make it possible to escalate the dose to the target and protect healthy tissue at the same time. The optimal volume of irradiation, total dose, fraction dose, techniques of radiotherapy, and the end points used during the follow-up are open to debate. In recent years a few clinical trials involving hormonal therapy and radiotherapy have been carried out. The most important of these are: RTOG 8307, RTOG 8610, RTOG 9202, and EORTC 22863. In the RTOG 8307 trial the comparison of outcomes of a combined treatment with a matched-control group of patients treated by radiotherapy alone has shown that adding hormonal therapy to radiotherapy resulted in a better outcome. Another trials RTOG 8531 and RTOG 8610 produced benefit due to the implementation of hormonal therapy in radiotherapy. The EORTC trial No. 22863 showed improvement in the 5-year overall survival when hormonal therapy after the completion of radiotherapy was continued for 3 years in the investigational arm. The RTOG 9202 study indicated benefit obtained from 2 years of adjuvant hormonal therapy...


    1417/2523

    Tytuł oryginału: Alternative end joining during switch recombination in patients with Ataxia-Teleangiectasia.
    Autorzy: Pan Qiang, Petit-Fr‚re Corinne, L„hdesm„ki Aleksi, Gregorek Hanna, Chrzanowska Krystyna H., Hammarstr”m Lennart
    Źródło: Eur. J. Immunol. 2002: 32 (5) s.1300-1308, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 312,318

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Ataxia-Teleangiectasia (A-T) and Nimegen breakage syndrome (NBS) are recessive genetic diseases with similar cellular phenotypes that caused by mutations in the recently described ATM (encoding ATM) and NBS1 (encoding p95) genes, respectively. Both disorders are accompanied by immunodeficiency in a majority of patients, but the mechanism involved has as yet not been established. We demonstrate that in cells from A-T patients, the switch (S) recombination junctions are aberrant and characterized by a strong dependence on short sequence homologies and devoid of normally occurring mutations around the breakpoint. A low number of S fragments were generated in cells from NBS patients and showed only limited dependence on sequence identify and mutation frequencies were similar to those observed in normal controls. We propose that ATM and p95 are both involved in the final (step(s) in class switch recombination with related, but disparate, functional roles. Thus, the general pathway involved in DNA repair also has a major influence on the immunoglobulin isotype switching process.


    1418/2523

    Tytuł oryginału: Increased IL-10 production during spontaneous apoptosis of monocytes.
    Autorzy: Bzowska Małgorzata, Guzik Krzysztof, Barczyk Katarzyna, Ernst Martin, Flad Hans-Dieter, Pryjma Janusz
    Źródło: Eur. J. Immunol. 2002: 32 (7) s.2011-2020, il., bibliogr. 46 poz.
    Sygnatura GBL: 312,318

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Monocytes/macrophages undergo apoptosis and are in contact with apoptosis cells both in vitro and in vivo. The data show that monocytes undergoing spontaneous apoptosis in vitro change their cytokine production profile. We demonstrate that the lipopolysaccharide (LPS)-induced production of interleukin-10 (IL-1)) is up-regulated, while production of proinflammatory cytokines such as tumor necrosis factor-ŕ (TNF-ŕ) and interleukin-1á (IL-1á) is either not affected or reduced. These differences seen both at the protein and mRNA level directly correlate with the appearance of apoptotic cells in the culture. Flow cytometry analysis using double staining, surface with annexin V and intracellular with anti-IL-10, suggested that annexin V-negative monocytes are the predominant source of IL-10. Analysis of sorted populations of monocytes indicated that the increase in IL-10 synthesis appears to result from direct interactions between non-apoptotic and apoptotic cells at the time of stimulation. Also non-apoptotic, freshly isolated monocytes produced more IL-10 upon stimulation with LPS, Staphylococcus aureus or zymosan when apoptotic neutrophils were added to the culture. In contrast, monocyte-derived macrophages did not produce more IL-10 in the presence of apoptotic neutrophils. Finally, we found that the presence of apoptotic monocytes in the culture may influence specific immune responses. The data show that in the presence of annexin V-positive monotocyes CD-4 positive memmory T cells produce less IFN-ç upon stimulation with purified protein derivative of tuberculin...


    1419/2523

    Tytuł oryginału: Perspectives in cardiac ultrasound.
    Tytuł polski: Perspektywy badania ultrasonograficznego serca.
    Autorzy: Roelandt J. R. T. C., Bruining N., Bom N.
    Źródło: Prz. Lek. 2002: 59 (8) s.557-561, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1420/2523

    Tytuł oryginału: Clinical and echocardiographic features in patients with dilated cardiomyopathy: wave intensity and diastolic abnormality analysis.
    Tytuł polski: Klinicze i echokardiograficzne cechy pacjentów z kardiomiopatią rozstrzeniową: intensywność fali i analiza zaburzeń rozkurczu.
    Autorzy: Siniawski Henryk, Unbehaun Axel, Lehmkuhl Hans, Susanne Kapell, Schoen Frank, Hetzer Roland
    Źródło: Prz. Lek. 2002: 59 (8) s.562-567, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp: Kardiomiopatia rozstrzeniwa (KR) nie jest do końca poznaną jednostką chorobową, a pilnym i istotnym problemem oczekująacym na zbadanie jest odpowiednia klasyfikacja chorych w oparciu o którą można by było precyzyjnie przewidzieć indywidualny przebieg schorzenia. Kryteria oceny stosowane dziś, oparte na objawach klinicznych, a także na czynnościowych badanaich nie inwazyjnych i inwazyjnych, są dalekie od doskonałości. Ocena maksymalnego zużycia tlenu (max. VO2) jako wskaźnika-kryterium niewydolności serca u chorych z KR jest badaniem czasochłonnym i bardziej opisującym wydolność krążeniowo-oddechową całkowitą a w mniejszym stopniu dającą speacyficzne informacje o chorym sercu. Zdefiniowanie obciążenie serca wydaje się być kluczem do rozwiązania problemu oceny chorego serca. Stan wydolności zintegrowanego układu sercowo-naczyniowego i jego obciążenia może być opisany w oparciu o nową metodę tzw. określania "Fali Intensywnej" (Wave Intensity = WI). Metoda ta opiera się o określenie fali ciśnienia i jej szybkości wewnątrz naczynia. Badania te są wstępnymi doświadczeniami nad użytkowaniem metody oznaczania "Fali Intensywnej" w Deutsches Herzzentrum Berlin u chorych w końcowym stadium kardiomiopatii rozstrzeniowej, u chorych po transplantacji serca i u zdrowych ochotników. Materiał i metoda: Z grupy 182 chorych z KR znajdujących się na liście transplantacji, zbadano trzydziestu jeden ambulatoryjnych chorych (17 proc.) Grupa A). Chorzy byli w wieku średnio 43 ń 14,2 lata, pośród których było 16 mężczyzn i 20 kobiet. Maksymalne zużycie tlenu wynosiło średnio 16,1 (ń 9,810 mg/kg/min...


    1421/2523

    Tytuł oryginału: Prevalence and risk factors for airway diseases in farmers - summary of results of the European Farmers' Project.
    Autorzy: Radon Katja, Monso Eduard, Weber Christoph, Danuser Brigitta, Iversen Martin, Opravil Ulrike, Donham Kelley, Hartung J”rg, Pedersen Soeren, Garz Susanne, Blainey David, Rabe Uta, Nowak Dennis
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.207-213, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the European Farmers' Project was to determine prevalence and risk factors of respiratory diseases in farmers across Europe. A cross-sectional study in 7 centres was carried out. In the first stage of the study, nearly 8000 farmers in Denmark, Germany, Switzerland, the UK, and Spain answered a standardised questionnaire on farming characteristics and respiratory symptoms. The second stage of the study included exposure assessment and lung function measurements in 4 of the centres. Within the group of farmers, pig farmers were at high risk of asthma-like syndrome as compared to farmers keeping other kinds of animals. Among plant farmers, greenhouse workers were at higher risk for symptoms of asthma. The prevalence of symptoms of allergies were significantly lower among animal farmers as compared to the population of the European Community Respiratory Health Survey. In contrast, animal farmers had a signifcantly higher prevalence of symptoms of chronic bronchitis. The major risk factor for respiratory symptoms was shown to be ventilation of the animal houses and greenhouses. Intervention studies are now warranted to test the effectiveness of improved ventilation on respiratory health. The reasons for the low prevalence of allergic diseases among farmers are currently under study.


    1422/2523

    Tytuł oryginału: Distribution of dermally absorbed 14C DDT in the organs of wistar rats.
    Autorzy: Toś-Luty Sabina, Tokarska-Rodak Małgorzata, Latuszyńska Jadwiga, Przebirowska Daniela
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.215-223, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of study was evaluation of the concentration of dermally applied 14C DDT in the organs of rats, and evaluation of histological and ultrastructural changes after the dermal application of unlabelled DDT standard in the organs of rats, in which the presence of this pesticide was determined by the radio-isotopic method. 14C DDT of radiochemical purity of 97 p.c. was applied in the study. The activity of the preparation per 1 cmý of the tail skin was 22.2 kB2 -n (175.38 ćg DDT). The material for the study was taken directly after single exposure and 6 h, 8 h, 10 h, 12 h, 14 h, 18 h and 20 h after exposure. The following organs were taken for the determination of radioactivity of tissues: brain, heart, lung, liver, kidney, skin at the site of exposure. Unlabelled chemically pure, DDT (99.7 p.c.) was used to evaluate histological and ultrastructural changes after dermal application. Experimental animals received an oil emulsion of DDT (10 mg/9 cmý), applied to the skin of the tail for 4 weeks. The time of exposure was 4 h daily. The animals of the control group were dermally exposed to the emulsion at the same time and under the same conditions. 4 h after dermal exposure it was observed that the preparaation applied on the surface of 9 cmý in the amount of 1.578 ćg was present in the skin in the amount of 1 ćg/9 cmý (0.11 ćg/cmý), i.e. 0.063 p.c. of 14C DDT applied dose. Directly after dermal application lasting 4 h the greatest amount of 14C DDT was noted in the liver - 0.285 ćg, i.e. 0.033 ćg/g. Histopatological and ultrastructural changes were observed in the liver, kidney, lungs and heart.


    1423/2523

    Tytuł oryginału: Exposure to airborne microorganisms and endotoxin in a potato processing plant.
    Autorzy: Dutkiewicz Jacek, Krysińska-Traczyk Ewa, Skórska Czesława, Cholewa Grażyna, Sitkowska Jolanta
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.225-235, il., tab., bibliogr. 72 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Microbiological air sampling was performed in a big potato processing plant located in eastern Poland. Air samples for determination of concentrations of microorganism, dust and endotoxin were collected at 6 sites in the division producing potato flakes and meal from dried potato pulp and at 2 sites in the division producing potato syrup from imported starch. The concentrations of total airborne microorganisms were within a range of 28.3 - 93.1 x 10**3. Mesophilic bacteria were dominant at all sampling sites, forming 73.1 - 98.8 p.c. of the total count. Among them, distinctly prevailed corynebacteria (irregular Gram-positive rods) that accounted for 54.3 - 81.1 p.c. of the total airborne microflora. The most common were strains of Corynebacterium spp., followed by strains of Arthrobacter spp., Microbacterium spp., and Agromyces ramosus. The later species, so far not reported from the air of occupational environments, abundantly develops in the parenchyma of potato tubers. Its airborne concentration increased rapidly after peeling of potatoes, and attained maximal values at cutting and blanching (steaming and sulfuration) of potatoes, and at sacking of potato meal. The proportions of Gram-negative bacteria and endospore-forming bacilli were low, respectively 0.6 - 7.6 p.c. and 2.0 - 8.1 p.c. of total count. Fungi constituted 1.2 - 26.9 p.c. of total count. The dominant species was Asprgillus niger that formed 99.8 p.c. of total airborne fungi. The values of the respiraable fraction of airborne microflora varied between 25.3 - 73.2 p.c. The concentrations of airborne dust were 1.4 - 26.6 mg/m3...


    1424/2523

    Tytuł oryginału: Precipitin response of potato processing workers to work-related microbial allergens.
    Autorzy: Dutkiewicz Jacek, Skórska Czesława, Krysińska-Traczyk Ewa, Cholewa Grażyna, Sitkowska Jolanta, Milanowski Janusz, Góra Anna
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.237-242, il., tab., bibliogr. 43 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Serum samples from 61 potato processing workers and 30 urban dwellers not exposed to organic dusts (as a reference group) were examined in agar-gel precipitation test performed by Ouchterlony double diffusion method with the antigens of 12 microorganisms associated with organic dusts. Each serum was tested twice: not concentrated, and three-fold concentrated, for the detection of low levels of precipitins. The antibody response of workers to the antigen of coryneform bacterium Agromyces ramosus was high, at both not concentrated and 3-fold concentrated sera (respectively 29.5 p.c. and 45.9 p.c.) - significantly greater than in reference group (p 0.001). Workers' response to the antigens of Gram-negative bacterium Alcaligenes faecalis and thermophilic actinomycete Thermoactinomyces vulgaris was lower (respoectively 13.1 p.c. and 13.1 p.c. at not concentrated sera, 24.6 p.c. and 29.5 p.c. at 3-fold concentrated sera) but in all cases significantly greater than in reference group (p 0.05 at not concentrated sera, p 0.01 and p 0.001 at 3-fold concentrated sera). The frequency of positive precipitin reactions of potato workers to antigen of Penicllium citrinum was high only at 3-fold concentrated sera (55.7 p.c.) - significantly higher compared to reference group (p 0.001). The antibody response of potato workers to other antigens was either unspecific or low, showing no significant difference compared to reference group. Twenty eight out of 61 examined potato processing workers (45.9 p.c.) reported the occurence of the work related pulmonary symptoms. The frequency of postivie....


    1425/2523

    Tytuł oryginału: The effects of exposure to organic dust on the respiratory system of potato processing workers.
    Autorzy: Milanowski Janusz, Góra Anna, Skórska Czesława, Mackiewicz Barbara, Krysińska-Traczyk Ewa, Cholewa Grażyna, Sitkowska Jolanta, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.243-247, tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: A cross-sectional study was carried out to evaluate lung function and the prevalence of work-related symptoms in workers of a potato processing plant located in Lublin region (easern Poland). The study group comprised 61 workers employed in 2 depertments. The examination included: physician-administrated questionnaire on occurence of work-related symptoms, occupational history and smoking habits. Spirometry was performed before (7.00 - 8.00) and after (f16.00 - 17.00) the morning shift. Altogether 41/61 (67.2 p.c.) subjects reported at least one symptom associated with their job. Pulmonary symptoms were recorded in 28/61 (45.9 p.c.) subjects. The most commonly recorded complaints were: cough (44.3 p.c.), hoarseness (19.7 p.c.), shorteness of breath (f18 p.c.), followed by headache and skin lesion (13.1 p.c. each), and eye and nose irritation (11.5 p.c.). The prevalence of work-related symptoms (except for eye and nose irritation) was higher in the group of subjects wroking longer than 4 years (the difference was statistically significant only for skin lesion). Among non-smoking workers a significantly higher prevalence of headache was seen compared to smokers (Fisher's test, p 0.05). Smokers complained more frequently of respiratory symptoms such as cough, shortness of breath, hoarseness and chest pain. The difference was significant only for cough (p 0.05) A statistically sifnificant over-shift decline in all measured spirmoetric values: FVC, FEV1 (p 0.001), FEV1/VC (p 0.05), PEF (p 0.01) was observed.


    1426/2523

    Tytuł oryginału: Occupational airborne and hand dermatitis to hop (Humulus lupulus) with non-occupational relapses.
    Autorzy: Śpiewak Radosław, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.249-252, tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: We report a case of a 57-years-old female faremr with occupational airborne dermatitis and hand dermatitis to hop (Humulus lupulus). The disease appeared at the age of 46, after 30 years of working with hop without any health problems. The patient had skin erythema of the face, neck and d‚collet‚, oedema of the eyelids, conjunctivitis, as well as acute dermatittis of the hands. The symptoms were provoked both by fresh and dried hop, appeared after half-an-hour of working and persisted over 1 - 2 days. There were no other skin or allergic problems. Skin test were carried out with hop leaves (saline exatract: prick positive, patch negative, glycerol extract: prick positive, path negative) and hop cones (saline extract: prick positive, patch negative; glycerol extract: prick negative, patch positive after 48 and 72 hours). Despite discontinuing work, the patient experienced several relapses of her dermatitis. We identified new sources of hop allergens: a beauty cream and a herbal sedative, both containing hop extract. During the next hop cultivation period it also turned out that sleeping in one bed with her husband was provoking relapses of the patient's dermatitis. The husband admitted that sometimes he felt too tired to wash thoroughly after working on the plantation. Our case shows that connubial contacts with husband working in the same workplace may cause relapses of occupational dermatitis. To our knowledge, this is the first report on the concurrent occupational and connubial dermatitis to hop.


    1427/2523

    Tytuł oryginału: Positive findings of Borrelia burgdorferi in Culex (Culex) pipiens pipiens larvae in the surrounding of Brno city determined by the PCR method.
    Autorzy: Żakovska Alena, Nejedla Petra, Holikova Alena, Dendis Milos
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.257-259, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: After first finding Borrelia in the midgut of imago mosquitoes, we concentrated on the presence of Borrelia in mosquitoe development stages - larvae of the third or fourth instar. In the summer season in the years of 2000 - 2001 a total of 439 Culex (Culex) pipens pipens larvae were collected from a barrel of rainwater in the Obrany holiday area of Brno city (East Moravia, Czech Republic). The larvae midgut was observed under dark-field microscopy. Ten DFM positive samples (2.28 p.c.) were further analysed using the single-tube nested PCR method for the presence of flagellum DNA sequence specific for Borrelia burgdorferi sensu lato, of which 5 were positive. Borrelian positivity of Culex (C.) pipens pipens larvae was 1.14 p.c. One spirochete isolated strain in BSK-H medium was obtained. PCR detection for borrelian DNA of the isolated strain was negative. From these results we can conclude that a low percentage Borreliae can be also found in mosquitoe larvae and are likely to survive into imago stage.


    1428/2523

    Tytuł oryginału: Legionella in sprinkling water as a potential occupational risk factor for gardeners.
    Autorzy: Stojek Nimfa Maria, Dutkiewicz Jacek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.261-264, tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: To study a possibility of infection with Legionella at gardening by inhaling of water aerosolized at sprinkling of plants, samples of tap water used for sprinking of plants grown in outdoor gardens and in greenhouses in the Lublin province (eastern POland) were examined for the presence of Legionella, along with the samples of soil, artificial medium and air collected in modern greenhouses. The strains of Legionella were isolated from 8 our of 36 samples of water (22.2 p.c.) collected from outdoor taps used for sprinking plants cultivated in outdoor gardens, and from 5 out of 20 samples of water (25.0 p.c.) collected from indoor taps used for sprinking of plasnts cultivated in traditional greenhouses or foil tunnels. Both in the samples collected from outdoor and indoor taps Legionella pneumophila 2 - 14 was more common that Legionella spp. (respectively 13.9 p.c. vs. 8.3 p.c., and 15.0 p.c. vs. 10.0 p.c.). No legionellae were found in 18 samples of tap water, 14 samples of soil, 14 samples of artificial medium or 6 samples of air collectd in modern greenhouses. The results of this preliminary study suggest that water aerosolized at sprinking of plants represents a potential source of Legionella infection among gardeners.


    1429/2523

    Tytuł oryginału: Social and health insurances in agriculture, Lublin, 23-25 October 2002. IX International Symposium on Ergonomics, Work Safety and Occupational Hygiene.
    Autorzy: Solecki Leszek
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.265-266 - 9 Międzynarodowe Sympozjum pt. Społeczne i zdrowotne ubezpieczenia w rolnictwie Lublin 23-25.10. 2002
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • ekonomika

    Typ dokumentu:
  • praca związana ze zjazdem
  • sprawozdanie
  • tytuł obcojęzyczny


    1430/2523

    Tytuł oryginału: Fast-track alfentanil general anaesthesia for open heart surgery: a review of our first forty valvular operations.
    Tytuł polski: Anestezja alfentanylem do operacji kardiochirurgicznych "krótkiej ścieżki" - wyniki naszych pierwszych 40 operacji zastawkowych.
    Autorzy: Vanek Tomas, Jares Martin, Straka Zbynek, Brucek Petr
    Źródło: Anestezjol. Intens. Ter. 2002: 34wyd.spec.C s.5C-7C, il., tab., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • anestezjologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie polskie: W pracy przedstawiono doświadczenia anestezji alfentanylem we wlewie 0,2 - 1,5 mg kg-1 min-1 poprzedzonych podaniem dawki nasycającej 20 mcg kg-1, midazolamem, propofolem, izofluranem i atrakurium, bez analgezji zewnątrzoponowej, do operacji zastawkowych w trybie "krótkiej ścieżki". Opisaną metodę zastosowano u 40 kolejnych pacjentów w wieku 67 ń 11 lat, ze średnią frakcją wyrzutową 59 ń 12 proc. i ocenionych w skali EURO na 5 pkt (2 - 12). W 19 przypadkach wymieniono zastawkę aortalną, w 15 oprócz zastawki aortalnej wykonano pomostowanie naczyń wieńcowych, u 4 wymieniono zastawkę mitralną, a u 2 pacjentów poddano operacji Bentalia z pomostowaniem naczyń wieńcowych. Średni czas trwania perfuzji wyniósł 55 ń 16 min, zakleszczenia aorty 43 ń 12 min, a całej operacji - 198 ń 47 min. Na całą operację zużyto średnio 12 ń 3,9 mg alfentanylu (151 ń 40 mcg kg-1). Ekstubacja bezpośrednio na stole nie była głównym ocenianym parametrem, niemniej jednak 19 (47,5 proc.) chorych usunięto rurkę bezpośrednio na sali operacyjnej w okresie 10 minut od zaszycia skóry. Pozostałych chorych ekstubowano w oddziale intensywnej terapii w 41 ń 40 min po zabiegu. Dwóch chorych reoperowano z powodu krwawienia i tamponady serca. Żaden chory nie wymagał późniejszej intubacji z powodu niewydolności oddechowej czy też krążenia, nikt też nie umarł w okresie 30 dni od operacji. Anestezja alfentanylem może być polecana do zabiegów "krótkiej ścieżki" przeprowadzonych z zastosowaniem krążenia ...

    Streszczenie angielskie: Experience with fast-track general anaesthesia based on alfentanil (loading dose 20 mcg kg-1 followed by continuous infusion of 0.2 - 1.5 mcg kg-1 min-1) + midazolam, propofol, isoflurane and atra-curicum, without epidueal catheter insertion, for cardiac valve surgery, is reported. The method was used in 40 consecutive, unselected patients, aged 67 ń 11 years, with mean left ventricular ejection fraction 59 ń 12 p.c., median EuroSCORE 5 (2-12). The patients underwent aortic valve replacement - AVR in 19 cases, combined procedures: AVR + coronary artery bypass grafting (15), mitral valve replacement (4), Bentall operation + coronary artery bypass grafting (2). The mean duration of cardiopulmonary bypass was 55 ń 16 min, mean aortic occlusion time was 43 ń 12 min, mean time of surgery 198 ń 47 min. The average total dose of alfentanil per procedure was 12 ń 3.9 mg (151 ń 40 mcg kg-1). Immediate extubation was not the primary end point of the study, but 19 patients (47,5 p.c.) met standard extubation criteria very early and were extubated in the operating room within 10 minutes after skin closure; others were trasported to the ICU and extubated within 41 ń 40 min. Two patients required early surgical revision due to postoperative bleeding or cardiac tamponade. None of the patients was reintubated due to respiratory or cardiac failure and none died within 30 days after surgery. We conclude that fast-tract alfentanil-based general anaesthesia con be recommended for ...


    1431/2523

    Tytuł oryginału: Postoperative bleeding in cardiac surgery; the role of thromboelastography.
    Tytuł polski: Krwawienie pooperacyjne w kardiochirurgii; znaczenie tromboelastografii.
    Autorzy: Mokrejs Jiri
    Źródło: Anestezjol. Intens. Ter. 2002: 34wyd.spec.C s.49C-52C, il., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • toksykologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie polskie: Przedstawiono dwa przypadki przedłużonego krwawienia pooperacyjnego po operacjach w krążeniu pozaustrojowym, których przyczyny nie udało się jednoznacznie określić tradycyjnymi badaniami laboratoryjnymi. W obu przypadkach tromboelastografia pozwoliła na wykrycie zaburzeń czynności płytek, spowodowanych niskocząsteczkową heparyną w pierwszym przypadku oraz - obecnością heparyny w tkankach - w drugim przypadku. Na tle tych obserwacji klinicznych omówiono znaczenie tromboelastografii w praktyce kardiochirurgicznej.

    Streszczenie angielskie: I describe two cases of prolonged postoperative bleeding after open-heart surgery that could not be diagnosed with traditional laboratory tests. Thromboelastography revealed a serious LMWH-induced thrombocyte dysfunction in the first case, and the presence of the residual tissue heparin - in the second one. The role and practical use of thromboelastography are discussed.


    1432/2523

    Tytuł oryginału: Anaesthesia and myocardial pre-conditioning.
    Tytuł polski: Anestezja a hartowanie mięśnia sercowego.
    Autorzy: Murali Bala, Latimer Ray
    Źródło: Anestezjol. Intens. Ter. 2002: 34wyd.spec.C s.63C-65C, bibliogr. 15 poz.
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • anestezjologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1433/2523

    Tytuł oryginału: Levosimendan in cardiac anaesthesia.
    Tytuł polski: Lewosimendan w kardioanestezji.
    Autorzy: Jalonen Jouko
    Źródło: Anestezjol. Intens. Ter. 2002: 34wyd.spec.C s.66C-67C, bibliogr. 16 poz.
    Sygnatura GBL: 305,376

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • farmacja
  • anestezjologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1434/2523

    Tytuł oryginału: The technique of total body irradiation applied at the Leszczyński Memorial Hospital.
    Autorzy: Kawa-Iwanicka Aneta, Dybek Marcin, Iwanicki Tomasz, Łobodziec Włodzimierz, Radkowski Andrzej
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (2) s.53-60, il., tab., bibliogr. 8 poz. - Konferencja pt. Postępy w radiologii onkologicznej - diagnostyka, leczenie, planowanie leczenia Poznań 19-21.04. 2001
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Purpose: To improve the reproductibility of patient positioning in fractionated irradiation and to achieve uniform irradiation of the patient, within 12-15Gy, excluding the lungs. Method: Two special body frames were manufactured, one for treatment planning and the other for the treatment itself. Special tin markers were inserted in the walls to make it possible for a patient to maintain the same position during each fraction of irradiation. Patient treatment was carried out in six fractions (four lateral and two AP/PA fields), twice a day, over three consecutive days. The lungs were shielded during AP/PA fractions and during one lateral fraction. The shape of the shields for AP/PA fields was determined with the use of computer tomography scans, and for lateral fields on the basis of radiographic pictures taken by a simulator. The doses calculated at some selected anatomical points for every patient were checked by in vivo measurements which were carried out by means of MOSFET detectors. Results and conclusions: Reproductibility of patient positioning during consecutive treatments and a uniform total dose distribution over the range of 12-15 Gy (except in the lungs) have been achieved. This has been confirmed by in vivo measurements.


    1435/2523

    Tytuł oryginału: Results of postoperative radiotherapy in lowgrade gliomas.
    Autorzy: Kępka Lucyna, Fijuth Jacek, Leszczyk Czesława, Dyttus-Cebulok Katarzyna, Zolciak Agnieszka
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (2) s.61-73, il., tab., bibliogr. 41 poz. - Konferencja pt. Postępy w radiologii onkologicznej - diagnostyka, leczenie, planowanie leczenia Poznań 19-21.04. 2001
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • pediatria
  • radiologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Purpose: To evaluate results of postoperative radiotherapy (PRT) for Low-Grade Gliomas (LGG). Material and methods: Between and 1955, 158 patients with LGG (WHO II) received PRT. A multivariate analysis for possible prognostic factors was performed. CT scans taken prior to surgery and at the time of recurrence were compared to define the recurrence pattern in relation to initial tumour site and the irradiated volume. Results: Ten-year overall and progression free survival rates were 41 p.c. and 29 p.c., respectively. A multivariate analysis revealed that good WHO performance status, seizures at presentation, duration of symptoms before treatment 12 months, age 54 years and gross total resection were associated with increased survival. All but three analysed recurrences occurred within the initial tumor sites. Three was only one case of recurrence outside the previously irradiated volume. Conclusion: Long-term treatment results were unfavourable for most LGG patients. Our data confirm the prognostic value of the above-mentioned factors.


    1436/2523

    Tytuł oryginału: Radiobiological considerations of re-irradiation tolerance of the spinal cord.
    Autorzy: Supe Sanjay S., Ganesh K. M., Velmurugan J., Rana B. S., Sankar B. N.
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (2) s.81-85, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Re-irradiation tolerance of the spinal cord depends upon the volume of the spinal cord irradiated, the total dose, the dose per fractional, the elapssed time between the treatment and the region of the spinal cord involved. Clinical data on the treatment tolerance of the spinal cord are sparse and inconclusive. Radiobiological laboratory evidence has indicated the presence of long term recovery of the spinal cord damage. Fractionation sensitivity during reirradiation is comparable with the first session of radiation treatment. After an initial dose of 45 Gy, 50 p.c. recovery reported by Schulthesis and Stephens for an elapsed period of two years for re-irradiation considerations.


    1437/2523

    Tytuł oryginału: Changing definitions of Public Health in the UK - their implications on Public Health education in practice.
    Tytuł polski: Zmiany definicji zdrowia publicznego w Wielkiej Brytanii - ich znaczenie praktyczne dla edukacji w dziedzinie zdrowia publicznego.
    Autorzy: Whitfield Malcolm, Smith Anthony
    Źródło: Zdr. Publ. 2002: 112 (2) s.149-151
    Sygnatura GBL: 301,109

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny


    1438/2523

    Tytuł oryginału: Monitoring labour market success of Faculty of Health Sciences alumni.
    Tytuł polski: Monitoring sukcesu absolwentów Wydziału Nauk o Zdrowiu na rynku pracy.
    Autorzy: Biesma R. G., Roulaux C., Groot W., Merode G. Van
    Źródło: Zdr. Publ. 2002: 112 (2) s.152-155, tab., bibliogr. 5 poz.
    Sygnatura GBL: 301,109

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny


    1439/2523

    Tytuł oryginału: Defining genetic public health skills. The context and the literature.
    Tytuł polski: Określenie umiejętności w zakresie zdrowia publicznego. Kontekst i piśmiennictwo.
    Autorzy: Smith Anthony, Giles Melanie, Whitfield Malcolm, Hind Daniel
    Źródło: Zdr. Publ. 2002: 112 (2) s.156-161, bibliogr. 60 poz.
    Sygnatura GBL: 301,109

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny


    1440/2523

    Tytuł oryginału: Przegląd profesjonalnych kompetencji w zakresie zdrowia publicznego.
    Tytuł angielski: Overview on professional competence in Public Health.
    Autorzy: Biesma R. G., Czabanowska K[atarzyna], Groot W., Vaatstra H. F., Merode G. Van
    Źródło: Zdr. Publ. 2002: 112 (2) s.168-174, bibliogr. 24 poz., sum.
    Sygnatura GBL: 301,109

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: Celem artykułu jest dokonanie przeglądu dostępnej literatury na temat konceptualizacji, oraz omówienie perspektyw i klasyfikacji kompetencji zawodowych. Następnie opisano wybrane badania dotyczące identyfikacji podstawowych kompetencji w dziedzinie zdrowia publicznego. Dla celów projektu LEONARDO da Vinci: 'Poprawa zatrudnienia wśród absolwentów zdrowia publicznego' potrzebne jest jasne zrozumienie jak można określić, zmierzyć i rozwinąć kompetencje, oraz uznanie faktu, że wymagania dotyczące kompetencji zmieniają się i będą wciąż się zmieniać na stale rozwijającym sie rynku. Celem projektu LEONARDO da Vinci jest określenie kompetencji kluczowych dla specjalistów zdrowia publicznego starających się o zatrudnienie, opracowanie narzędzia samooceny dla absolwentów oraz przyjęcie programów edukacyjnych dla potrzeb rynku pracy w dziedzinie zdrowia publicznego. W oparciu o przegląd badań dotyczących kompetencji zawodowych stwierdzono, że istnieje potrzeba dalszego rozwoju i doskonalenia pojęcia kompetencje zawodowe w zakresie zdrowia publicznego.


    1441/2523

    Tytuł oryginału: Measuring employers' preferences for competences of junior Public Health professionals.
    Tytuł polski: Pomiar preferencji pracodawców dotyczących zakresu wiedzy absolwentów zdrowia publicznego.
    Autorzy: Biesma R. G., Pavlova M., Groot W., Vaatstra H. F., Merode G. Van
    Źródło: Zdr. Publ. 2002: 112 (2) s.175-181, bibliogr. 18 poz., sum.
    Sygnatura GBL: 301,109

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: Na wstępie artykułu krótko omówiono różne metody pomaru kompetencji. Celem badań nad projektem EU LEONARDO jest analiza preferencji pracodawców w odniesieniu do wymaganych kompetencji absolwentów zdrowia publicznego w Wielkiej Brytanii, Polsce i Holandii. Proponowane metody składaja się z pośredniego pomiaru kompetencji przy użyciu dwóch metod, które się wzajemnie uzupełniają i dostarczają wskazówek co do wiarygodności badań ankietowych.


    1442/2523

    Tytuł oryginału: Prehl'ad urazov na zakladnych skolach v skolskych rokoch 1996-2000 v okrese Nitra
    Autorzy: Sutka Vladimir
    Źródło: W: Integracja w procesie kształcenia i wychowania fizycznego - Wrocław, 2002 s.333-338, il., tab., bibliogr. 2 poz., sum. - 5 Międzynarodowa Konferencja Naukowa "Dydaktyka wychowania fizycznego" pt. Integracja w procesie kształcenia i wychowania fizycznego Olejnica 09-11.09. 2001
    Sygnatura GBL: 735,968

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1443/2523

    Tytuł oryginału: Unknown lung pathology in patients with cystic fibrosis is becoming known.
    Autorzy: Kulczycki Lucas L., Castro Henry J., Castro Marcela Jimenez, Bellanti Joseph A.
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.81-87, il., tab., bibliogr. 54 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska


    1444/2523

    Tytuł oryginału: Clinico-pathological aspects of radiofrequency ablation in the treatment of benign thyroid tumors.
    Autorzy: Nawrot Ireneusz, Grzesiuk Wiesław, Kluge Przemysław, Wojtaszek Mikołaj, Kyzioł-Otto Grażyna, Otto Maciej, Buczyńska-Chyl Jolanta, Karwacki Jerzy, Jędrasik Maciej, Chudziński Witold, Pietrasik Kamil, Dębińska-Szymańska Tamara, Jaworski Maciej, Bar-Andziak Ewa, Tołłoczko Tadeusz, Woźniewicz Bogdan M., Szmidt Jacek
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.97-101, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the study was to standardize a dependable method, which would be used to differentiate thyroid carcinoma in fine-needle biopsies and to adapt radiofrequency ablation techniques to safety treat benign thyroid tumors. Fine-needle aspiration biopsies, taken pre- and intraoperatively were assessed cytologically and histologically. Immunochemical markers (PCNA, Ki67 and AgNOR) were used to differentiate between carcinoma and benign folicular adenomas. Apoptosis was studied in benign tumors using TUNEL, Bcl-2, CD95 and Bax immunoassays. Ablation was performed intraoperatively on thyroid tissue fragments ranging in size from 1,3 to 2,2 cm, mean 1,7 ń 0,5 prepared for resection with full blood perfusion of the gland. AgNOR silver staining was used to assess the number of active nucleoi "NORs". Benign proliferation showed a number of 1-2 nuceloli, in adenomas 4-6 nucleoli and 8 nucleoli in malignancies. PCNA showed highest specificity where 80 p.c. of cancerous cells had positive results. The Ki67 marker in primary cancer showed no staining and stained positive in 50 p.c. of metastatic cancer. Apoptosis was also not increased in the case of adenomas. In the 58 patients undergoing the procedure we noted in 4 patients (6,1 p.c.) temporary laryngeal nerve paralysis, in 2 (3 p.c.) cases minute bleeding after needle arm retraction. To conclude: 1) the suggested assay panel is able to discriminate between follicular carcinoma and adenoma, 2) radiofrequency ablation can be an alternative to surgical methods in neutral nodular goiter, 3) necrosis zone of the ablated thyroid lesion is closely correlated to the used ablation parameters.


    1445/2523

    Tytuł oryginału: Pathology of endocrine pancreas in persistent hyperinsulinemic hypoglycemia in children - practical diagnostic considerations.
    Autorzy: Pronicki Maciej, Grajkowska Wiesława, Iwanicka Katarzyna, Szymańska-Dębińska Tamara, Taybert Joanna, Drewniak Tomasz
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.103-108, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Persistent hyperinsulinemic hypoglicemia (PHH) is connected with many different histopathological lesions of endocrine pancreas. Their character may be both cytological and architectural. The previously widely used term nesidioblastosis caused much confusion because of lack of strict criteria. At present most authors recognise two basic forms: focal and diffuse. This concept provides the basis for possible effectiveness of limited surgery with the aid of intraoperative frozen sections. In many patients defined molecular abnormalities related to hyperfunction and proliferation of beta cells were reported. The aim of the study was to reassess histopathological slides from resection specimens of the pancreas from 70 children with PHH aged 1 week to 16 years treated in our institution. Multiple blocks were step-sectioned and stained routinely as well as immunohistochemically to visualise all 4 types of endocrine cells. Age matched control group consisted of 40 pancreata obtained during autopsy from children who died due to endocrine unrelated events. Ten possible different abnormal features of endocrine cell population were recorded. The following different patterns of lesions were found: 1.adenoma; 2.focal adenomatosis; 3.diffuse florid "nesidiodysplasia" type; 4.diffuse with minimally hypertrophic endocrine nuclei; 5. diffuse only with distinct hypertrophic nuclei; 6.diffuse borderline; 7.normal histology. We concluded that focal lesions underlying PHH in children are clearly defined pathologically, and have reliable morphological criteria...


    1446/2523

    Tytuł oryginału: Functional disturbances of urinary tract in children with recurrent urinary tract infections and enuresis nocturna.
    Autorzy: Winiecka Wiesława
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.109-111, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the work was to assess the function of lower urinary tract in children with primary enuresis nocturna and recurrent urinary tract infections. Urodynamic examinations (uroflowmetry and cystometry) were done using Duet f. Dantec. The examinations were carried out in 87 children at the age from 5 to 16 years (mean age 8,6 year), who were divided in groups: I - 49 children without anatomical abnormalities in urinary tract, II - 38 children with vesicoureteral refluxes of II degree. The results showed disturbances of urinary tract in (73/87) children, more often in group II. The most frequent abnormality in both groups was detrusor instability (44/87), decreased cystometric capacity of bladder (18/87) and sphincter-detrusor dyssynergia (9/87). In children with primary enuresis nocturna and recurrent urinary tract infections, disturbances of urinary tract function appear in over 80 p.c.


    1447/2523

    Tytuł oryginału: Determination of anti-calreticulin antibodies in sera of children with untreated celiac disease: comparison with anti-endomysial and anti-reticulin antibodies.
    Autorzy: Zegadło-Mylik Maria, Cukrowska Bożena, Rujner Jolanta, Syczewska Małgorzata, Socha Jerzy, Woźniewicz Bogdan M.
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.113-116, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Calreticulin (CRT) has been identified as one of the autoantigens of anti-gliadin antibodies found in celiac disease. In this study we have examined the validity of serum anti-CRT antibody levels in patients with celiac disease and in control group and assessed their sensitivity and specificity against standard serological tests. Serum IgA anti-CRT antibody levels measured by ELISA and IgA anti-endomysial antibodies (EmA) and IgA anti-reticulin antibodies (ARA) by indirect immunofluorescence were determined in 35 untreated celiac disease and in 24 non-celiac controls. IgA EmA and IgA ARA antibodies were positive in 32 and 34 patients (sensitivity 91,4 and 97,1 p.c.). IgA anti-CRT antibodies were positive in 15 celiac patients out of 33 examined (sensitivity 45,5 p.c.). No controls were ARA, EmA and anti-CRT positive. Our results revealed that anti-CRT antibodies despite their high specificity in IgA (100 p.c.) have limited value in screening programs for celiac disease.


    1448/2523

    Tytuł oryginału: The incidence of nodular lymphoid hyperplasia of the colon in children with different types of chronic constipation.
    Autorzy: Romańczuk Wrzesław, Woźniewicz Bogdan M., Samojedny Antoni
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.117-123, il., tab.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: The terms lymphonodular hyperplasia are used to denote those changes in the mucosa of the gastrointestinal tract that appear as small, 1-5 mm nodes in radiological studies and/or endoscopy and histologically are seen as a lymphoid follicular pattern. The objective of this study was to attempt to assess the frequency of lymphonodular hyperplasia of the colon (lnhpc) in children with various types of chronic constipation. The study encompassed 122 patients from the pediatric ward and pediatric outpatient department of the gastroenterology clinic treated between 1999 and 2002 for chronic constipation. The diagnosis of lnhpc was based on rectoscopic examination (the presence of at least 10 enlarged lymph nodules) and the results of histological examination (proctitis chronica follicularis non-specifica). Our results showed that lnhpc in children with chronic constipation is an unfavorable prognostic factor and may be indicative of greater disturbances of the colon, manifesting as distinct slowing of intestinal transit time. Lnphc may point to a role of allergy in the development of constipation in children. We concluded that in cases when lnhpc is defined in a child, it is necessary to expand diagnosis to include total and segmental colonic transit times and allergy testing.


    1449/2523

    Tytuł oryginału: Fibrinogen/fibrin and albumin colocalize on the surface of placental villi - a novel element of feto-maternal barrier?
    Autorzy: Wasiutyński Aleksander, Wilczyński Grzegorz M., Morton Marcin, Koperski Łukasz, Górnicka Barbara, Ziarkiewicz-Wróblewska Bogna
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.125-129, il., bibliogr. 14 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The phenomenon of fetal escape from maternal anti-allogenic immune response is not completely understood. It was hypothesized that fibrininogen/fibrin and albumin, derived from plasma, can form on the surfaces of various cells, a complex, which is able to prevent the access of immune-competent cells and molecules. In this report, we have investigated, using immunohistochemical approach, whether such a complex could exist on the surface of villi in the human placenta. By means of both peroxidase-based and fluorescent techniques, we have immunolocalized fibrinogen/fibrin and albumin in paraffin sections of normal termplacentas, obtained upon delivery from 11 women. We found marked deposition of both fibrinogen/fibrin and albumin around the villi, in the form of dense layers covering respectively 78,4 ń 1,4 p.c. and 82,4 ń 1,2 p.c. of the villous surface. At those sites, both immunoreactivities strictly colocalized, as revealed by doublelabel immunofluorescent confocal microscopy. The analysis of fluorescence-resonance energy transfer (FRET) between fluorophores indicated that a substantial portion of fibrinogen/fibrin and albumin molecules on the villous surface are separated from each other by the distance smaller or equal to 30nm. Our results the presence of an inter-molecular complex between fibrinogen/fibrin and albumin on the surface of human trophoblast, which might constitute a novel element of a protective barrier at the feto-maternal interface.


    1450/2523

    Tytuł oryginału: Lipoblastoma with a new chromosomal translocation.
    Autorzy: Wang Huanghua, Greco Alba, Ahmed Atif
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.131-134, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: Lipoblastoma is a rare pediatric adipose tissue tumor that has to be distinguished from lipoma and myxoid liposarcoma. Cytogenetic studies can help in the differential diagnosis. Most lipoblastoma cases show cytogenetic alterations involving chromosome 8. We review the literature and report a case of a lipoblastoma in a 9-month old male infant with t(2;12)(q32;q15) translocation. According to our knowledge this is the first reported case of lipoblastoma with this translocation.


    1451/2523

    Tytuł oryginału: Desmoplastic infantile ganglioglioma - rare large supratentorial tumour of infancy with favourable prognosis. Case report.
    Autorzy: Grajkowska Wiesława, Pronicki Maciej, Barszcz Sławomir, Roszkowski Marcin, Gładkowska-Dura Małgorzata
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.135-137, il., bibliogr. 14 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • płeć żeńska

    Streszczenie angielskie: We present a case of a large cystic brain tumour in 8-month-old infant characterized by the following clinicopathologic features: presentation in early infancy; massive size with a large cystic and small solid component; supratentorial location in the frontoparietal region; astroglial, neuronal and desmoplastic elements and a good outcome following complete surgical resection. Pertinent literature data are discussed.


    1452/2523

    Tytuł oryginału: Difficulties in the diagnosis of paediatric craniopharyngioma.
    Autorzy: Mrugacz Małgorzata, Oziębło-Kupczyk Monika, Średzińska-Kita Dorota, Bakunowicz-Łazarczyk Alina
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.139-140, bibliogr. 17 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • okulistyka
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Craniopharyngioma is the most common childhood tumour and thought to arise from embryonic remmants of Rathke's pouch. We reported a case of a 17-year-old girl with craniopharyngioma.


    1453/2523

    Tytuł oryginału: Annals of Diagnostic Paediatric Pathology
    Tytuł angielski: Cushing's disease in a 5 months infant due to a basophilic microadenoma of the pituitary gland.
    Autorzy: Ferraz Maria Lucia da Fonseca, Oliveira Gamaniel de, Almeida Joao, Reis Marlene Antonia dos, Teixeira Vincente de Paula Antunes, Castro Eumenia Costa da Cunha
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.141-143, il., bibliogr. 29 poz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: We report a five-month old girl with classical clinical features of Cushing's syndrome. Histological findings showed a basophilic microadenoma of the pituitary gland, leading to a diagnosis of Cushing disease (CD). The child died because of untreatable septic shock. The importance of the present report resides in the age of the child at the diagnosis. CD is the most often diagnosed in children older than seven years, and our patient was only five months old when we detected the pituitary adenoma, this was the earliest case diagnosed thus far. Cushing's syndrome in pediatric patients has been rarely reported and most of the cases are due to functioning adrenal tumour, usually a malignant carcinoma but occasionally a benign adenoma. The present case shows that the pituitary of this patients should be investigated with important implications in terms of therapeutic approaches such as radiotherapy of the pituitary, which can cure the patient when treatment is started as soon as possible.


    1454/2523

    Tytuł oryginału: A scanning electron microscopic study of phenotypic plasticity and surface structural changes of aortal smooth muscle cells in primary culture.
    Autorzy: Tukaj Cecylia, Bohdanowicz Jerzy, Kubasik-Juraniec Jolanta
    Źródło: Folia Morphol. 2002: 61 (4) s.191-198, bibliogr. 15 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Phenotypic modulation of smooth muscle cells (SMCs) from a contractile to a synthetic state characterised by active proliferation appears to be an early event in the pathogenesis of atherosclerosis. A similar transition occurs when SMCs are established in culture. In this study the phenotypic plasticity and surface structural changes of aortal smooth muscle cells during the transition from the contractile to the synthetic state and during maturation have been structurally assesed by scanning electron microscope (SEM). The experiments were performed on SMCs obtained from aorta of neonatal rats after enzymatic digestion and then cultured on glass cover slips. SEM obsrvations revealed a three-dimensional appearance characteristic for different stages of SMCs. Intensively proliferating cells from monolayer region were large, polygonal in shape with lamellipodia and well spread. Long, uniform in diameter, finger-like microvilli were densely arranged on the surface of these cells. In the thickened region of culture, the cells were rather small, generally spindle-shaped, not well spread, with low density of short, bubble-like microvilli on the surface. Numerous plasma membrane structural altrations in apoptotic cells were observed by SEM; loss of cellular adhesion, smoothing, shrinkage and outpouching of membrane segments have been recognised as markers associated with the cell injury and death. It was concluded that scanning microscopy observations would allow a more complete understanding of SMCs and their changes in culture and atherosclerotic disease.


    1455/2523

    Tytuł oryginału: Morphology of the temporal canal and postglenoid foramen with reference to the size of the jugular foramen in man and selected species of animals.
    Autorzy: Wysocki Jarosław
    Źródło: Folia Morphol. 2002: 61 (4) s.199-208, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The jugular foramen and postglenoid foramen are the main venous foramina of the skull of placental mammals. Their mutual relations are closely related to the development of teh internal and external jugular vein, depending on the given kind. On the basis of measuring studies, it was decided to investigate the relations of the size of these foramina and to quantitatively determine which of them prevails. The studies were performed with macerated human and animal skulls. Altogether 100 skulls of human adults of both sexes, 100 of macaccas, 67 of bisons, 25 of mongrel dogs, 37 of foxes and 25 of rats wer examined. The jugular foramen was the outlet of the sigmoid sinus or its equivalents and the postoglenoid foramen was the outlet of the sigmoid sinus or its equivalents and the postglenoid foramen - the petrosquamous ofr temporal canal. The jugular foramen was always singular and characterised by a small variability in the morphology, consisting only in the occurrence of sht internal division or its lack. The postglenoid foramen, on the other hand, in the majority of the studied kinds was variable and numerous. The numbr of foramina ranged from 1 in man to 7 - 10 in bisons. In the cours of measurement, it was found that the area of the postglenoid foramen in relation to the area of the jugular foramen is 0.897 p.c. in man, 24 p.c. in macaccas, 30.7 p.c. in dogs, 34.4 p.c. in foxes, 53.9 p.c. in rats and 248.5 p.c. in bisons. The results obtained indicate that in bisons the system fo venous sinuses, connected with the postglenoid foramina, has a decisive significance for the drainage of...


    1456/2523

    Tytuł oryginału: Imunocytochemical evidence for growth hormone-releasing hormone in the tanycytes of the median eminence of the rat.
    Autorzy: Carretero Jos‚, Burks Deborah, Rubio Manuel, Blanco Enrique, Herrero Julio J., Bodego Pilar, Juanes Juan A., Hernandez Elena, Riesco Jos‚ M.
    Źródło: Folia Morphol. 2002: 61 (4) s.209-216, il., tab., bibliogr. 69 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The current study was performed to analyse the potential existence and structure of a GHRH-transporting tuberoinfundibular system in the rat median eminence. The immunocytochemical analysis using anti-GHRH revealed an intense immunoreaction in the ependimary cells, tanycytes, at the level of the floor of the infundibular recess forming part of the median eminence. The basal processes of these cells course towards the external layer of the median eminence and reach the growth hormone-releasing hormone (GHRH) fibres of the tuberoinfundibular tract and this reaction was incrase after intraventricular treatment with colchicine. Thus, these observations suggest the existence of a second ora alternative cerebrospinal fluid-mediated route of GHRH transport to the median eminence and implicate the involvement of tanycytes in the regulation of this novel transport system.


    1457/2523

    Tytuł oryginału: Alterations in cell nuclei during apoptosis.
    Autorzy: Rogalińska Małgorzata
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.995-1018, tab., bibliogr. 114 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Apoptosis is a genetically programmed phenomenon that aids in maintaining homeostasis in multicellular organisms. The characteristic morphological features of apoptosis are highly conservative and are dependent on the cell type and the apoptotic inducer. The nuclear events occurring during apoptosis include changes at the molecular level (i.e. DNA cleavage, modifications of nuclear polypeptides, and proteolysis of several proteins important for cell maintenance), and, consequently, alterations at the morphological level (i.e. chromatin condensation, nuclear shrinkage, DNA fragmentation and apoptotic body formation). These events are still not fully understood. It is very probable that a progressive decrease in pH could also be an essential factor for the induction of nuclease and protease activities, and an important element of the op[timal conditions for their function. This review details teh current state of knowledge on apoptotic nuclear events, with particular focus on the proteins involved in the execution of apoptosis in cell nuclei, and on the differences in substrate cleavage profiles for different types of cell undergoing cell death.


    1458/2523

    Tytuł oryginału: The isoform- and location-dependence of the functioning of the plasma membrane calcium pump.
    Autorzy: Żylińska Ludmiła, Kawecka Iwona, Lachowicz Lilla, Szemraj Janusz
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1037-1045, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The plasma membrane is a specialised multi-component structure with inter- and intracellular signalling functions. Ca**2+ plays a crucial role in cellular physiology, and an ATP-driven plasma membrane calcium pump (PMCA) plays the greatest role in the maintenance of a low free Ca**2+ concentration in the cytoplasm. The enzyme is coded by four separate genes (PMCA 1-4), and, due to alternative splicing, more than 20 variants can exist. PMCA 1 and 4 isoforms are present in almost all tissues, whereas PMCA 2 and 3 are found in more specialised cell types. The variants differ primarily in their regulatory regions, thus the modulation of calcium pump activity strongly depends on teh isoform and the membrane omposition. The unique function of PMCA isoforms was confirmed using the practical experimental models - a rat pheochromocytoma cell line, a human neuroblastoma cell line, or, more recently knockout mice. In addition, based on the finding that PMCA could interact with several specific signaling proteins, it was concluded that its location in defined sites of the cell membrane could be a prerequisite for efficient intercellular communication.


    1459/2523

    Tytuł oryginału: Effect of intramuscular application of selected neuropeptides on morphology of muscle.
    Autorzy: Gendek-Kubiak Hanna
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1059-1064, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna
  • komunikat

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie
  • płeć męska

    Streszczenie angielskie: The aim of the study was to examine a morphological picture of guinea pig skeletal muscles injected with neuropeptide Y (NPY), substance P (SP) or vasoactive intestinal peptide (VIP), to evaluate the influence of a single injection of the mentioned neuropeptides (NPS) on muscle morphology and mast cell, T lymphocyte an dmarcophage chemotaxis. There were different degrees of muscle fibre injuries as well as different intensities an dcompositions of infiltrations inside the muscle after the introduction of the NPS. The observed changes did not disappear, but increased after 24 hours, comparing to the 3-hour post-injection changes, suggesting that NPS are proinflammatory rather than antiinflammatory factors in skeletal muscles. The, local particularly delayed action of NPS in vivo requires further studies.


    1460/2523

    Tytuł oryginału: Reactive oxygen species upregulate expression of PAI-1 in endothelial cells.
    Autorzy: Świątkowska Maria, Szemraj Janusz, Al-Nedawi Khalid N.I., Pawłowska Zofia
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1065-1071, il., bibliogr. 18 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • tytuł obcojęzyczny
  • komunikat
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Second messenger involved in the signal transduction pathway leading to induction of the plasminogen activator inhibitor (PAI-1) have not yet benn wellharacterized. This study focuses on the mechanisms of regulation of PAI-1 expression by reactive oxygen species (ROS) in human endothelial cells. Inhibition of the tumor necrosis factor ŕ (TNFŕ)-induced expression of PAI-1by antioxidant N-acetyl-L-cysteine (NAC) indicated redox - sensitive mechanisms involved in the signalling pathway. Because TNFŕ induces PAI-1 production in endothelial cells, and NAC attenuated this response, we attempted to investigate the possible involvement of ROS in the activation of PAI-1 by TNFŕ. Upregulation of PAI-1 expression in endothelial cells by the stimulation with TNFŕ (50ng/ml) or H2O2 (10-200ćM), observed by measurement of the antigen and mRNA levels, was reversed in the presence of NAC (20 mM). The stimulatory effect of ROS was detected also at the level of the PAI-1 promoter in endothelial cells transfected with plasmid p800 LUC containing a PAI-1 promoter fragment (+71 to -800). The PAI-1 promoter activity was increased in the presence of ROS, and was suppressed by up to 75 p.c. in the presence of antioxidants. [1]. On the basis of this study we can conclude that reactive oxygen species play an important role in a cytokine-induced activation of PAI-1 expression, and may act as a signal transduction messenger.


    1461/2523

    Tytuł oryginału: Dynamin: characteristics, mechanism of action and function.
    Autorzy: Wiejak Jolanta, Wyroba Elżbieta
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1073-1080, bibliogr. 34 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Dynamin - a member of teh GTP-ase protein family - is essential for many intracellular membrane trafficking events in multiple endocytic processes. The unique biochemical features of dynamin -especially its propensity to assemble - enable severing the nascent vesicles from the membrane. The mechanism of dynamin's action is still a subject of debate - whether it functions as a mechanochemical enzyme or a regulatory GTPase. The GTPase domain of dynamin contains three GTP-binding motifs. This domain is very conservative across the species., including that recently cloned by us in the unicellular eukaryote Paramecium. Dynamin interacts with a number of partners such as endophilin and proteins involved in coordination of endocytosis with motor molecules. A growing body of evidence indicates that dynamin an ddynamin-related proteins involved both in pathology and protection against human diseases. The most interesting are dynamin-like Mx proteins exhibiting antiviral activity.


    1462/2523

    Tytuł oryginału: Thioridazine induces erythrocyte stomatocytosis due to interactions with negatively charged lipids.
    Autorzy: Hendrich Andrzej B., Lichacz Katarzyna, Burek Anna, Michalak Krystyna
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1081-1086, il., bibliogr. 15 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Despite the fact that thioridazine is used clinically as a neuroleptic drug, little is known about the molecular mechanisms underlying its biological effects, in particular about its interactions with membranes. In the present work we investigate the influence of thioridazine on model and cell membranes, using calorimetry, DPH fluorescence polarization measurements, studies of haemodialysis and scanning electron microscopy. The experiments show that thioridazine interacts with lipid bilayers and intercalates into bilayer structure. We found that erythrocyte stomatocytosis induced by the drug might be related to preferential interaction of thioridazine with charged lipids.


    1463/2523

    Tytuł oryginału: The influence of membrane lipid metabolites on lymphocyte potassium channel activity.
    Autorzy: Teisseyre Andrzej, Michalak Krystyna, Kuliszkiewicz-Janus Małgorzata
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1095-1109, il., bibliogr. 23 poz.
    Sygnatura GBL: 306,513

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study, the whole-cell patch-clamp technique was applied to elucidate modulatory effects of high-density lipoproteins (HDL), sphingosine (SPH), sphingosine-1-phosphate (SPP), lysophosphatidic acid (LPA) and sphingosyl- phosphorylcholine (SPC) on the activity of Kv1.3 channels in human T lymphocytes (TL). Obtained data provide evidence that application of SPC at micromolar concentrations shifts teh channel activation midpoint by about 20 mV towards positive membrane potentials. This effect occurs in a concentration-dependent manner and is saturated at SPC concentrations higher than 10 ćM. The shift of channel activation midpoint is accompanied by a pronounced slowing of the activation kinetics. The modulatory effect of SPC is clearly voltage-dependent, being most potent at -20 mV and least potent at +60 mV. The steady-state inactivation curve is also shifted by about 20 mV towards positive membrane potentials. The kinetics of channel inactivation and deactivation (closure) remain unaffected upon SPC treatment. In contrast, application of HDL (250 ćg/ml), SPH (50 and 100 ćM), SPP (10 ćM) and LPA (10 and 36 ćM) does not exert any modulatory effect on the channel activity. The effect of SPC on Kv1.3 channel gating resembles the effect exerted by extracellular zinc at the concentration of 10 ćM. It is concluded that the effect of SPC is specific and may be due to the presence of a choline residue in SPC molecules. The possible mechanism and the physiological significance of this modulatory effect on Kv1.3 channels are discussed.


    1464/2523

    Tytuł oryginału: The adjuvant activity of lactoferrin in the generation of DTH to ovalbumin can be inhibited by bovine serum albumin bearing ŕ-D-mannopyranosyl residues.
    Autorzy: Kocięba Maja, Zimecki Michał, Kruzel Marian, Actor Jeffrey
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1131-1136, il., bibliogr. 6 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Lactoferrin (LF) is an iron-binding glycoprotein present in the cytoplasmic granules of neutrophils and in external secretions of mammals. Although the biological role of human and bovine lactoferrin has been extensively studied, there is still uncertainty as to the nature and function of lactoferrin receptors. We recently determined that methyl-ŕ-D-mannopyranoside given intraperitoneally (i.p.) could suppress the adjuvant activity of LF in the generation of delayed-type hypersensitivity (DTH) to ovalbumin (OVA). We concluded that the lactoferrin effects in DTH are mediated by carbohydratrecognizing receptors like the mannose receptor (MR). This study indicates that subcutaneous (s.c.) administration of very small doses of the Man-bovine serum albumin (Man-BSA) complex, together with a sensitizing dose of the antigen, gives the same effects as i.p. administration of methyl-ŕ-D-mannopyranoside. The latter is aso a blocker of MR, although of a much lower affinity to the ereceptor than Man-BSA. The blocking of the adjuvant effect of LF by the Man-BSA complex (when given together with the sensitising dose of antigen) suggests that the function of antigen-presenting cells in the skin (presumably) immature dendritic cells expressing MR) is inhibited. The results of our study indicate that a receptor with an affinity for mannose is essential for the mediation of adjuvant lactoferrin function in th egeneration of DTH.


    1465/2523

    Tytuł oryginału: Natriuretic peptides reduce plasminogen activator inhibitor-1 expression in human endothelial cells.
    Autorzy: Pawłowska Zofia, Jerczyńska Hanna, Szemraj Janusz, Barańska Patrycja, Świątkowska Maria, Cierniewski Czesław S.
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1153-1157, il., bibliogr. 10 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Plasma concentrations of natriuretic peptides increase in some pathological conditions, but very little is known about the effect of these vasodilator peptides on the regulation of the blood coagulation system. The fundamental role in the regulation of fibrinolysis is played by plasminogen activator inhibitor type 1 (PAI-1). Recent studies demonstrate that natriuretic peptides can modulate PAI-1 expression in bovine aortic smooth muscle cells and rat aortic endothelial cells. In this report, we tested the effect of natriuretic peptides on PAI-1 expression in the human endothelial cell line (EA.hy 926). For this purpose, we treated the cell cultures with ANP, BNP and CNP, and modulation of PAI-1 synthesis was evaluated. We compared the effect of natiuretic peptides on synthesis and release of PAI-1 in unstimulated cells, and after activation with tumour necrosis factor ŕ (TNFŕ). Natriuretic peptides abolished TNFŕ- induced upregulation of PAI-1 expression at both the PAI-1 mRNA and the antigen levels. The inhibitory efficiency was higher in the case of CNP when compared to that produced by ANP and BNP, particularly when TNFŕ-stimulated cells were used. We observed an inhibition of stimulatory effect of TNFŕ on PAI-1 expression also at the level of the PAI-1 promoter in cells transfected with a PAI-1 promoter fragment (+71 to -800). The PAI-1 promoter activity was markedly inhibited by C-type natriuretic peptide, already at a very low (0.001 ćM) concentration of the peptide.


    1466/2523

    Tytuł oryginału: The exertional compartment syndrome: a review of the literature.
    Tytuł polski: Powysiłkowy zespół przedziałów powięziowych. Przegląd literatury.
    Autorzy: Verleisdonk E. J. M. M.
    Źródło: Ortop. Traumatol. Rehabil. 2002: 4 (5) s.626-631, il., tab., bibliogr. 48 poz., streszcz.
    Sygnatura GBL: 313,531

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Autor dokonał przeglądu piśmiennictwa omawiającego powysiłkowy zespół przedziałów powięziowych, który może wystąpić w formie ostrej lub przewlekłej podczas uprawiania sportu i ćwiczeń. Przewlekła (powysiłkowa) postać występuje częściej niż zespół ostry i w większości przypadków lokalizuje się w przedniej i bocznej komorze mięśniowej goleni. W tym artykule przeglądowym opisano cechy kliniczne tego zespołu i omówiono niektóre niejasności dotyczące anatomii, patofizjologii, diagnostyki i postępowania. Autor stwierdza, że jedynym logicznym sposobem leczenia zespołu ciasnoty przedziałów powięziowych jest fasciotomia, niewielki ale skuteczny zabieg chirurgiczny o niskiej częstości powikłań.


    1467/2523

    Tytuł oryginału: Angiogenesis and some prognostic parameters of invasive ductal breast carcinoma in women.
    Autorzy: Olewniczak Sławomir, Chosia Maria, Kwas Artur, Kram Andrzej, Domagała Wenancjusz
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.183-188, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The purpose of the study was to correlate angiogenesis parameters (micorvessel count, area and perimeter) with some clinical and morphological factors in 251 invasive ductal breast carcinomas in women. Endothelium was stained with antiCD31 antibody, and measurements were made using a computerised image analysis in the whole study population and separately for two subgroups with and without metastases to acillary lymph nodes. High angiognesis parameters in primary tumours were associated with older age, large tumour diameter, high grade and the associations were statistically significant. Furthermore the microvessel density was signifcantly higher in tumours metastasing to lymph nodes as compared with tumours without metastases. Mcirovessel perimeter was found to be the most useful of vessel parameters analysed. The corrlation between angigonesis and some clinical and morphological parameters, especially lymph node status may indicate the prognostic value of angiognesis in invasive ductal breast carciomas.


    1468/2523

    Tytuł oryginału: Genetic analysis of HER-2/neu gene amplification in paraffin embedded tumour tissue in women with breast cancer.
    Autorzy: Zadrożny Marek, Smolarz Beata, Romanowicz-Makowska Hanna, Kozłowska Elżbieta, Kulig Andrzej
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.189-193, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: In recent years several novel prognostic determinants of breast cancer have been identified, including HER-2/neu. The oncogene called HER-2/neu or c-erbB-2 located at 17q21 encods a 185-kD transmembrane glycoprotein, p185. THe HER-/neu gene is frequently overexpressed in human breast cancers as a result of gene amplification and/or elevated transcription. In this study we investigated the association between the presnce of HER-1/neu gene amplification and appearance and/or progression of breast cancer. Paraffin embedded tumour tissue was obtained from 82 women with breast cancer. Blood samples from age mateched healthy women served as control (n = 50). The amplification of HER-2/neu gene was determined by PCR amplification of HER-2/neu gene was determined by PCR amplification using appropriate primers. The amplification of HER/2/neu gene was significantly higher in women with breast cancer as compared with conrol (P 0.05). Additionally, there were differences in the amplification status betwen node-positive and node-negative breast cancer patients. The results suggest that the presence fo amplification of HER-2/neu gene may be linked with the appearance and/or progression of breast cancer.


    1469/2523

    Tytuł oryginału: The expression of tumorigenesis markers in oral papilloma.
    Autorzy: Reszeć Joanna, Sulkowska Mariola, Famulski Waldemar, Guzińska-Ustymowicz Katarzyna, Sulkowski Stanisław
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.195-200, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Oral papilloma is the most frequent benign tumor of the oral cavity but its biological potential for malignant transformation is still to be evaluated. The alteration of apoptosis and uncontrolled cell proliferation is considered to be an important factor in oral tumorigenesis. The aim of our study was to evaluate by immunohistochemistry P53, Bcl-2, CD44 and PCNA expression in oral papillomas with and wityout dysplasia. We examined a series of 55 oral papillomas, including 12 (21.8 p.c.) cases of papillomas with epithelial dysplasia. Staining patterns were correlated with sex, age, tumor location, size and presence or absence of epithelial dysplasia. P53 showed positive reaction in 70.9 p.c. PCNA in 80 p.c., CD44 in 50.9 p.c. and Bcl-2 in 21.8 p.c. of papillomas. Ther was no correlation between sex, age, tumor size, location and presence of dysplastic epitehelium in papillomas. We observed a statistically significant correlation between Bcl-2, CD44 expression and presence of epithelial dysplasia in papillomas. Coexistence of PCNA and P53 positive immunostaining was observed. Papillomas with overexpression of P53 adn PCNA showed negative reaction for CD44 protein. The results of our study suggest that overexpression of P53 and PCNA might be an early event in oral tumorigenesis, whereas CD44 and Bcl-2 are potential markers of epithelial dysplasia in oral papillomas.


    1470/2523

    Tytuł oryginału: Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats.
    Autorzy: Dzięgiel Piotr, Surowiak Paweł, Rabczyński Jerzy, Zabel Maciej
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.201-204, il., bibliogr. 29 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • gastroenterologia
  • kardiologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: In the course of anthracyclin administration, melatonin acts as an effective scavenger of oxygen free radicals and exerts cardio- and nephroprotective effects. The present study aimed at corroborating cytostatic effectiveness of daunorubicin, applied in parallel with melatonin, in rats with transplanted Morris hepatoma. The percentage of tumour cells, which manifested traits of necrosis was recorded and extent of apoptosis was evaluated in tumour cells and in cells of myocardium. Daunorubicin administration was followed by a significant increase in necrosis and apoptosis in tumour cells and by intensified apoptosis in myocardium cells. Melatonin administered in parallel with daunorubicin decreased the extent of necrosis in tumour cells and reduced the proportion of apoptotic cardiomyocytes.


    1471/2523

    Tytuł oryginału: The influence of BMOV [bis(maltolato)oxovanadium(IV)] on biochemical and morphological alterations characteristic for streptozotocin-diabetic rat liver Golgi complexes.
    Autorzy: Dąbroś Wojciech, Dziga Dariusz, Kordowiak Anna M.
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.205-213, il., tab., bibliogr. 44 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The activity of galactosyltransferase (GalT), the Golgi apparatus marker enzyme, together with the morphology of this organelle in rat liver, are so characteristic that we have used them for twenty years as a test of streptozotocin-diabetes, and of the efficacy of different drugs. Bis-Maltolato)oxovanadium(IV) (BMOV), an oral vanadium complex with anti-diabetic properties, best of these drugs, was seen to reverse the previously found biochemical and morphological changes. Four groups of diabetic rats were studied in different conditions: 1) untreated diabetes (D group), 2) pre-treatment with BMOV for two days, to accustom the animals to the taste of vanadium solution and to verify possible cytoprotection of the drug, followed by the induction of diabetes c. 3 weeks later (pVD group). The third group - 3) consisted of the rats, in which STZ-diabetes was induced followed by treatment of diabetic animals with 1.8 mmol BMOV in 0.5 p.c. NaCl for seven days (D+V group). The fourth group - 4) consisted of the animals treated as pVD group, followed by induction of diabetes three weeks later and treatment with BMOV (pVD+V group) for seven days. In agreement with other invesitagtors, the reduction of body weight was seen in all diabetic rats. Vanadium treatment caused the greatest body weight reduction. Liquid and food intake was lower in both groups at seven days after treatment with VMOV. Major biochemical alterations in yields of Golgi-richi membrane fraction were found in D, pVD and pVD+V groups. They were signifcantly lowe (p 0.01) than in D+V group. A significantly lower acitvity...


    1472/2523

    Tytuł oryginału: The influence of nitric oxide synthesis modulation on the pancreatic acinar cells in caerulein-induced acute pancreatitis. An ultrastructural and morphometric study.
    Autorzy: Andrzejewska Anna, Jurkowska Grażyna, Augustynowicz Albert
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.215-221, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The goal of our study was to evaluate the influence of NO synthesis modulation on the ultrastructural changes in the pancreatic acinar cells in connection with morphometric assessment of the volume and numerical densities of mitochondria (Vvm, Nvm) and zymogen granules (Vvz, Nvz) in caerulein-induced acute pancreatitis (AP). During AP induction rats were treated with L-arginine - substrate for NO syntheis, NG-nitro-L-arginine (L-NNA) - NO synthase inhibitor, gliceryl trinitrate (NTG) - NO donor, L-arginine+L-NNA or saline. This study demonstrated that administration of L-NNA leads to the formation of numerous, large autophagosomes and mitochondria oedema in pancreatic acinar cells. Treatment with L-arginine or NTG during AP induction resulted in a diminution of the ultrastructural changes with a concomitant increase of Vvz. Vvm and Nvm were significantly lower in the L-arginine treated group compared to the untreated AP. The results indicate that: L-NNA enhances damage to acinar cells which may be indicative of a protective role for endogenous NO in oedematous AP. The application of L-arginine or NTG decreases the damage to acinar cells evaluated ultrastructurally, suggesting the morphological changes accompanying the onset of AP in rats after the administration of either substrate for endogenous NO synthesis or oxogenous No donor follow a favourable course.


    1473/2523

    Tytuł oryginału: Immunofluorescence in situ and the serologic indices of Chlamydia pneumoniae infection in patients with an abdominal aortic aneurysm.
    Autorzy: Wolski Andrzej, Korobowicz Elżbieta, Siezieniewska Zofia, Mazur Elżbieta, Niedźwiadek Justyna, Kozioł-Montewka Maria, Michalak Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.223-228, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to evaluate the frequency of Chlamydia pneumoniae infection in patients with abdominal aortic aneurysm (AAA) using selected methods. The histological specimens of aneurysm wall were evaluated, the method of immunofluorescence was used to reveal the antigen in the wall of AAA and the titers of specific antibodies of IgG, IgM and IgA classes in blood plasma were marked. Atherosclerotic changes in the aneurysm wall were found in all patients. In 20 (87 p.c.) patients the C. pneumoniae antigen was seen in the wall of abdominal aneurysm using the indirect immunofluorescence method. A significant relation between the method of direct C. pneumoniae diagnosis, aneurysm symptoms and histologically detected inflammation in its wall was confirmed. Serologic markers of the chronic C. pneumoniae infection were seen in 20 (87 p.c.) out of 23 patients and in 6 (30 p.c.) out of 20 subjects of the control group and this difference was statistically significant. It was observed, that all patients with serologic indices of active C. pneumoniae infection, had symptomatic aneurysm. The presence of Chlamydia pneumoniae in the wall of AAA as well as the occurrence of serologic indices of the chronic infection in these patients can confirm the hypothesis of the relation between the infection with this microorganism and the development of the disease.


    1474/2523

    Tytuł oryginału: Asynchronous collecting duct carcinoma of the kidney and pulmonary adenocarcinoma. A case report.
    Autorzy: Okoń Krzysztof, Demczuk Sergiusz, Dobrowolska Barbara, Kaznowska Ewa, Dobrowolski Zygmunt, Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.229-234, il., bibliogr. 20 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • nefrologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Collecting duct carcinoma (CDC) is a rare renal malignancy accounting for about 0.4 - 2.6 p.c. of cases. We report a case of CDC in a 61-year-old woman previously operated on for pulmonary adenocarcinoma. On histological examination and immunohistochemical research diagnosis of asynchronous primary bronchial carcinoma and renal CDC was made. The authors review the available literature on CDC and differential diagnosis of metastatic versus primary renal carcinomas.


    1475/2523

    Tytuł oryginału: EBV-positive lymphoepithelial carcinoma of salivary gland in a woman of anon-endemic area - a case report.
    Autorzy: Białas Magdalena, Sińczak Anna, Choińska-Stefańska Agnieszka, Zygulska Aneta
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.235-238, il., bibliogr. 18 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • genetyka
  • mikrobiologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Lymphoepithelial carcinoma of the salivary glands is a very rare malignancy comprising not more than 0.4 p.c. of all salivary gland neoplasms in the non-endemic areas. In contrast it is much more frequent among native Greenlanders, North American Inuit (Eskimo) and Southern Chinese people living in Hong Kong. We report a case of a 74-year-old woman of Polish origin diagnosed with a lymphoepithelial carcinoma of the right parotid gland. The neoplastic cells were negative for EBV latent membrane protein (LMP-1), but in situ hybridisation for EBV mRNA (EBER) demonstrated positivity in almost all epithelial cells. No signs of EBV infection were found in the reactive lymphocytic component. The patient was treated with radiotherapy.


    1476/2523

    Tytuł oryginału: Pluribus unum of primary gastric antigen-dependent lymphomas.
    Autorzy: Gałązka Krystyna, Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (4) s.239-246, bibliogr. 79 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The paper presents start-of-art knowledge of primary gastric B-cell lymphomas. Despite the progress of the investigations, a lot of questions remain still unanswered and many doubts wait for explanation.


    1477/2523

    Tytuł oryginału: Myosins and pathology: genetics and biology.
    Autorzy: Rędowicz Maria Jolanta
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.789-804, il., bibliogr. s. 800-804 - 38 Spotkanie Polskiego Towarzystwa Biochemicznego Wrocław 09. 2002
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: This article summarizes current knowledge on the genetics and possible molecular mechanisms of human pathologies resulted from mutations within the genes encoding several myosin isoforms. Mutations within the genes encoding some myosin isoforms have been found to be responsible for blindness (myosins III and VIIA), deafness (myosins I, IIA, IIIA, VI, VIIA and XV) and familial hypertrophic cardiomyopathy (á cardiac myosin heavy chain and both the regulatory and essential light chains). Myosin III localizes predominantly to photoreceptor cells and is proved to be engaged in the vision process in Drosophila. In the inner ear, myosin I is postulated to play a role as an adaptive motor in the tip links of stereocilia of hair cells, myosin IIA seems to be responsible for stabilizing the contacts between adjacent inner ear hair cells, myosin VI plays a role as an intracellular motor transporting membrane structures within the hair cells while myosin VIIA most probably participates in forming links between neighbouring stereocilia and myosin XV probably stabilizes the stereocilia structure. About 30 p.c. of patients with familial hypertrophic cardiomyopathy havae mutations within the genes encoding the á cardiac myosin heavy chain and both light chains that are grouped within the regions of myosin head crucial for its functions. The alterations lead to the destabilization of sarcomeres and to a decrease of the myosin ATPase activity and its ability to move actin filaments.


    1478/2523

    Tytuł oryginału: Structural determinants of cooperativity in acto-myosin interactions.
    Autorzy: Moraczewska Joanna
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.806-812, il., bibliogr. 811-812 - 38 Spotkanie Polskiego Towarzystwa Biochemicznego Wrocław 09. 2002
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Regulation of muscle contraction is a very cooperative process. The presence of tropomyosin on the thin filament is both necessary and sufficient for cooperativity to occur. Data recently obtained with various tropomyosin isoforms and mutants in the thin filament for cooperative protein interactions. Forming an end-to-end overlap between neighboring tropomyosin molecules is not necessary for the cooperativity of the thin filament activation. When direct contacts between tropomyosin molecules are disrupted, the conformational changes in the filament are most probably transmitted cooperatively through actin subunits, although the exact nature of these changes is not known. The function of tropomyosin ends, alternatively expressed in various isoforms, is to confer specific actin affinity. Tropomyosin's affinity or actin is directly related to the size of the apparent cooperative unit defined as the number of actin subunits turned into the active state by binding of one myosin head. Inner sequences of tropomyosin, particularly actin-binding periods 3 to 5, play crucial role in myosin-induced activation of the thin filament. A plausible mechanism of tropomyosin function in this process is that inner tropomyosin regions are either specifically recognized by myosin or they define the right actin conformation required for tropomyosin movement from its blocking position.


    1479/2523

    Tytuł oryginału: Directionality of kinesin motors.
    Autorzy: Kasprzak Andrzej A., Hajdo Łukasz
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.813-821, il., bibliogr. s. 820-821 - 38 Spotkanie Polskiego Towarzystwa Biochemicznego Wrocław 09. 2002
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesisns are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemcial and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.


    1480/2523

    Tytuł oryginału: Actin in human colon adenocarcinoma cells with different metastatic potential.
    Autorzy: Nowak Dorota, Krawczenko Agnieszka, Duś Danuta, Malicka-Błaszkiewicz Maria
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.823-828, il., bibliogr. s. 827-828 - 38 Spotkanie Polskiego Towarzystwa Biochemicznego Wrocław 09. 2002
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Four human colon adenocarcinoma cell line variants with different metastatic potential were used to examine whether a correlation exists between actin level, state of actin polymerization and invasiveness of tumour cells. Monomeric (G), toatal (T) and filamentous (F) actin were determined in the cytosolic fraction of these cells. A statistically significant decrease in G actin level and increase in the state of actin polymerization (measued by F : G actin ratio) were found in the cytosol of three cell variants with higher metastatic potential and invasiveness (EB3, 3LNLN 5W) compared with the parental cell line (LS180). Our experimental data lead to the conclusion that there is a correlation between the metastatic capacity of human colon adenocarcinoma cells and the state of actin polymerization.


    1481/2523

    Tytuł oryginału: Myosin molecule packing within the vertebrate skeletal muscle thick filaments. A complete bipolar model.
    Autorzy: Skubiszak Ludmiła, Kowalczyk Leszek
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.829-840, il., tab., bibliogr. s. 838-840 - 3845 Spotkanie Polskiego Towarzystwa BiochemicznegoDoroczne Spotkanie Towarzystwa Biofizycznego WrocławBoston 09. 20022001
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: Computer modelling related to the real dimensions of both the whole filament and the myosin molecue subfragments has revealed two alternative modes for myosin molecule packing which lead to the head disposition similar to that observed by EM on the surface of the cross-bridge zone of the relaxed vertebrate skeletal muscle thick filaments. One of the modes has been known for three decades and is usually incorporated into the so-called three-stranded model. The new mode differs from the former one in two aspects: (1) myosin heads are grouped into asymmetrical cross-bridge crowns instead of symmetrical ones: (2) not the whole myosin tail, but only a 43-nm C-terminus of each of them is straightened and near-parallel to the filament axis, the rest of the tail is twisted. Concurrent exploration of these alternative modes has revealed their influence on the filament features. The parameter values for the filament models as well as for the building units depicting the myosin molecule subfragments are verified by experimental data found in the literature. On the basis of the new mode for myosin molecule packing a complete bipolar structure of the thick filament is created.


    1482/2523

    Tytuł oryginału: The vertebrate skeletal muscle thick filaments are not three-stranded. Reinterpretation of some experimental data.
    Autorzy: Skubiszak Ludmiła, Kowalczyk Leszek
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.841-853, il., bibliogr. s. 851-853 - 3845 Spotkanie Polskiego Towarzystwa BiochemicznegoDoroczne Spotkanie Towarzystwa Biofizycznego WrocławBoston 09. 20022001
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: Computer simulation of mass distribution within the model and Fourier transforms of images depicting mass distribution are explored for verification of two alternative modes of the myosin molecule arrangement within the vertebrate skeletal muscle thick filaments. The model well depicting the complete bipolar structure of the thick filament and revealing a true threefold-rotational symmetry is a tube covered by two helices with a pitch of 2 x 43 nm due to arrangement of the myosin tails along a helical path and grouping of all myosin heads in the crowns rotated by 240ř ane each containing ghree cross-bridges separated by 0ř, 120ř, and 180ř. The cross-bridge crown parameters are verified by EM images as well as by optical and low-angle X-ray diffraction patterns found in the literature. The myosin tail arrangement, at which the C-terminus of about 43-nm length is near-parallel to the filament axis and the rest of the tail is quite strongly twisted arround, is verified by the high-angle C-ray diffraction patterns. A consequence of the new packing is a new way of movement of the myosin cross-bridges, namely, not by bending in the hinge domains, but by unwrapping from the thick filament surface towards the thin filaments along a helical path.


    1483/2523

    Tytuł oryginału: Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).
    Autorzy: Awasthi Sanjay, Sharma Rajendra, Yang Yusong, Singhal Sharad S., Pikula Sławomir, Bandorowicz-Pikula Joanna, Singh Shivendra V., Zimniak Piotr, Awasthi Yogesh C.
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.855-867, il., tab., bibliogr. s. 863-867
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: We have recently demonstrated that a previously known Ral-binding GTPase activating protein, RLIP76, can also catalyze ATP-dependent transport of various structurally unrelated xeno- and endobiotics irrespective of their net charge (Awasthi et al., 2000, Biochemistry, 39: 9327). RLIP76 is a non-ATP binding cassette (ABC) protien but it has two ATP-binding sites and shows basal ATPase activity which is stimulated in the presence of its transport substrates (allocrites) such as doxorubicin (DOX) and S-(2,4-dinitrophenyl) glutathione (DNP-SG). Proteoliposomes reconstituted with purified RLIP76 catalyze ATP-dependent, saturable transport of DOX, as well as of glutathione-conjugates including leukotrienes (LTC4) and the GSH-conjugate of 4-hydroxynonenal (GS-HNE). In erythrocytes the majority of transport activity for DOX, GS-HNE, and LTCA is a ccounted for by RLIP76. Cells exposed to mild oxidative stress show a rapid and transient induction of RLIP76 resulting in an increased efflux of GS-HNE and acquire resistance to oxidative stress mediated toxicity and apoptosis. Cells transfected with RLIP76 acquire resistance to DOX through increased efflux of the drug suggesting its possible role in the mechanisms of drug-resistance. In this article, we discuss the significance of transport functions of RLIP76 highlighting its role in the defense mechanisms against oxidative injury, and modulation of signaling mechanisms.


    1484/2523

    Tytuł oryginału: Transmembrane segment M2 of glycine receptor as a model system for the pore-forming structure of ion channels.
    Autorzy: Bednarczyk Piotr, Szewczyk Adam, Dołowy Krzysztof
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.869-875, il., bibliogr. s. 874-875
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The glycine receptor belongs to the ligand-gated ion channel superfamily. It is a chloride conducting channel composed of four transmembrane domains. It was previously shown that the second transmembrane domain (M2) of the glycine receptor forms an ion conduction pathway throught lipid bilayers. The amino-acid sequence of the transmembrane segment M2 of the glycine receptor has a high homology to all receptors of the ligand-gated ion channel superfamily. In our report, we have used a synthetic M2 peptide. It was incorporated into a planar membrane of known lipid composition and currents induced by M2 were measured by the Black Lipid Membrane technique. When the planar lipid bilayer was composed of 75 p.c. phosphatidylethanolamine and 25 p.c. phosphatidylserine, the reversal potential measured in a 150/600 mM KCl (sic/trans) gradient was - 19 mV suggesting that the examined pore was preferential to anions, PK/PCl = 0.25. In contrast, when 75 p.c. phosphatidylserine and 25 p.c. phosphatidylethanolamine was used, the reversal potential was +20 mV and the pore was preferential to cations, PK/PCCl = 4.36. SIngle-channel currents were recorded with two predominant amplitudes corresponding to the main-conductance and sub-conductance states. Both conductance states (about 12 pS and 30 pS) were measured in a symmetric solution of 50 mM KCl. The observed single-channel properties suggest that the selectivity and conductance of the pore formed by the M2 peptide of the glycine receptor depend on the lipid composition of the planar bilayer.


    1485/2523

    Tytuł oryginału: Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.
    Autorzy: Czajkowski Rafał, Barańska Jolanta
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.877-889, il., bibliogr. s. 886-889 - 4 Polsko-Ukraińska Konferencja im. Jakuba Parnasa Wrocław 15-17.09. 2002
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: In this reveiw we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptros involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on teh P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 adn P2Y12. The former is linked to phospholipase C and the later is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-triphosphate and cAMP mediated signalling, is discussed.


    1486/2523

    Tytuł oryginału: Hydrolysis of cyclic GMP in rat peritoneal macrophages.
    Autorzy: Witwicka Hanna, Kobiałka Marcin, Gorczyca Wojciech A.
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.891-897, il., bibliogr. s. 896-897 - 8 Polska Konferencja Biologii Komórki Wrocław 23-25.09. 2002
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Intact rat peritoneal macorphgaes (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. APDE activity toward [3H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca2+ /calmodulin-independent but increased in the presence of cGMP excess. Similar results were obtained when [3H]cAMP was used as a substrate. The hydrolytic activity towards both nucleotides was inhibited in the presence of IBMX. Therefore, the PDEs of families 2, 5, 10 and 11 are potential candidates for cGMP hydrolysis in the rPM. They may not only regulate the cGMP level in a feedback-controlled way but also link cGMP-dependent pathways with those regulated by cAMP.


    1487/2523

    Tytuł oryginału: Protective role of L-methionine against free radical damage of rat brain synaptosomes.
    Autorzy: Slyshenkov Vyacheslav S., Shevalye Anna A., Liopo Anton V., Wojtczak Lech
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.907-916, il., tab., bibliogr. s. 913-316
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Incubation of rat brain synaptosomal-mitochondrial fraction with tert-butylhydroperoxide resulted in accumulation of the lipid peroxidatin product, conjugated dienes, damage of teh synaptosomal membrane as evidenced by leakage of lactate dehydrogenase, and decrease of the total content of glutathione and of teh GSH/GSSG ratio. This treatment also produced a consideraable decrease of the ouabain-sensitive ATPase activity and a much smaller diminution of the activities of glutathione reductase and glutathione transferase. Preincubation of the synaptosomal/michochondrial fraction with 0.5 or 1.0 mM L-methionine significantly protected against lipid peroxidation, membrane damage and changes in the glutatione system produced by low (1 mM) concentrations of tert-butylhydroperoxide and completely preented inactivation of uabain-sensitive ATPase, gluathione reductase and glutathione transferease by such treatment. The importance of L-methionine in antioxidant protection is discussed.


    1488/2523

    Tytuł oryginału: Effect of natural phenols on the catalytic activity of cytochrome P450 2E1.
    Autorzy: Mikstacka Renata, Gnojkowski Jerzy, Baer-Dubowska Wanda
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.917-925, il., bibliogr. 923-925
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: The effect of protocatechuic acid, tannic acid and trans-resveratrol on the activity of p-nitrophenol hydroxylase (PNPH), an enzymatic marker of CYP2E1, was examined in liver microsomes from acetone induced mice. trans-Resveratrol was found to be the most potent inhibitor (IC50 = 18.5 ń 0.4 ćM) of PNPH, while protocatechuic acid had no effect on the enzyme activity. Tannic acid with IC50 = 29.6 ń 3.3 ćM showed mixed and trans-resveratrol competitive inhibition kinetics (Ki = 1 ćM and 2.1 ćM, respectively). Moreover, trans-resveratrol produced a NADPH-dependent loss of PNPH activity, suggesting mechanism-based CYP2E1 inactivation. These results indicate that trans-resveratrol and tannic acid may modulate cytochrome P45 2E1 and influence the metabolic activation of xenobiotics mmediated by this P450 isoform.


    1489/2523

    Tytuł oryginału: Species- and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration.
    Autorzy: Bełtowski Jerzy, Wójcicka Grażyna, Marciniak Andrzej
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.927-936, il., bibliogr. s. 935-936
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • zwierzęta
  • króliki
  • myszy
  • szczury
  • płeć męska

    Streszczenie angielskie: Paraoxonase 1 (PON1), contained in plasma high-density lipoproteins, plays an important role in the protection of plasma lipoproteins and cell membranes from oxidative damage. Previous studies indicate that human PON1 is stimulated by high NaCl concentrations. The aim of this study was to characterize in more detail the effect of salts on serum PON1. Paraoxon-hydrolyzing activity of human serum was stimulated by 81.6 p.c. following the addition of 1 M NaCl. The effect of NaCl was dose-dependent between 0.5 and 2 M. PON1 activity toward phenyl acetate was reduced by 1 M NaCl by 55.2 p.c. Both the paraoxon- and phenyl acetate-hydrolysing activity was slightly lower in heparinized plasma than in serum, but NaCl had similar stimulatory and inhibitory effects on these activities, respectively. In rat, rabbit, and mouse, NaCl reduced PON1 activity. KCl had a similar effect on human PON1 as NaCl. Sodium nitrite also stimulated human PON1 but much less effectively than chloride salts. In contrast, sucrose, sodium acetate and sodium lactate had no significant effect. NaBr was a less effective PON1 activator than NaCl, whereas the effect of NaJ was non-significant. The activity of human PON1 toward homogentisic acid lactone and ç-decanolactone was unaltered by NaCl. These data indicate that: 1) high concentrations of chlorides stimulate human PON1 activity toward paraoxon but not other substrates, 2) PONI is inhibited by Cl- in other mammalian species, 3) the potency of human PON1 activation by halogene salts increases with decreasing atomic mass of the halide anion.


    1490/2523

    Tytuł oryginału: Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression.
    Autorzy: Suematsu Naoya, Okamoto Kazuki, Isohashi Fumihide
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.937-945, il., tab., bibliogr. s. 944-945
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: A cytosolic aceytl-CaA hydrolase (CACH) cDNA has been isolated from mouse liver cDNA library and sequenced. Recombinant expression of the cDNA in insect cells resulted in overproduction of active acetyl-CoA hydrolyzing enzyme protein. The mouse CACH cDNA encoded a 556-amino-acid sequence that was 93.5 p.c. identical to rat CACH, suggestign a conserved role for this enzyme in the mammalian liver. Database searching shows no homology to other known proteins, but reveals homological cDNA sequences showing two single-nucleotide polymorphisms (SNAPs) in the CACH conding region. The discovery of mouse CACH cDNA is an important step towards genetic studies on the functional analysis of this enzyme bay gene-knockout and transgenic approaches.


    1491/2523

    Tytuł oryginału: Up-regulation of spermidine/spermine N1-acetyltransferase (SSAT) expression is a part of proliferative but not anabolic response of mouse kidney.
    Autorzy: Dudkowska Magdalena, Stachurska Agnieszka, Grzelakowska-Sztabert Barbara, Manteuffel-Cymborowska Małgorzata
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.969-977, il., bibliogr. s. 975-977
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: A differential expression pattern of spermidine/spermine N1-acetyltransferase (SSAT), the enzyme critical to proper homeostasis of cellular polyamines, is reported in mouse kidney undergoing hyperplasia and hypertrophy. We have shown that SSAT activity and SSAT mRNA are significantly induced by antifolate CB 3717 and folate that evoke a drug-injury-deendent hyperplasia. In contrast, SSAT activity mRNA is positively controlled by this androgen. Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717. Our results document that the increased SSAT Expression solely accompanies the proliferative response of mouse kidney, and suggest the importance of post-transcriptional regulation to the control of SSAT activity in both hyperplastic and hypertrophic experimental models.


    1492/2523

    Tytuł oryginału: IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.
    Autorzy: Trojan Ladislas A., Kopiński Piotr, Wei Ming X., Ly Adama, Głogowska Aleksandra, Czarny Jolanta, Shevelev Aleksander, Przewłocki Ryszard, Henin Dominique, Trojan Jerzy
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.979-990, il., bibliogr. s. 985-990
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Alterations in the expression of growth factors and their receptors are associated with the growth and development of human tumors. One such growth factor is IGF-I (insulin-like growth factor I), a 70-amino-acid polypeptide expressed in many fissues, including brain. IGF-I is also expressed at high levels in some nervous system-derived tumors, especially in glioblastoma. When using IGF-I as a diagnostic marker, 17 different tumors are considered as expressing the IGF-I gene. Malignant glioma, the most common human brain cancer, is usually fatal. Average survival is less than one year. Our strategy of gene therapy for the treatment of gliomas adn other solid tumors is based on: 1) diagnostic using IGF-I gene expression as a differential marker, and 2) application of "triple-helix anti-IGF-I" therapy. In the latter approach, tumor cells are transfected wtih a vector, which encodes an oligoribonucleotide - an RNA styrand containing oligopurine sequence which might be capaable of forming a triple helix with an oligopurine and/or oligopyrimidine sequence of the promotor of IGF-I gene (RNA-IGF-I DNA triple helix). Human tumor cells trensfected in vito become down-regulated in the production of IGF-I and present immunogenic (MHC-I adn B7 expression) and apoptotic characteristics. Similar results were obtained when IGF-I antisense strategy was applied. In both strategies the transfected cells reimplanted in vivo lose tumorigenicity and elicit tumor specific immunity which leads to elimination of establaished tumors.


    1493/2523

    Tytuł oryginału: Carbohydrate moieties of N-cadherin from human melanoma cell lines.
    Autorzy: Ciołczyk-Wierzbicka Dorota, Gil Dorota, Hoja-Łukowicz Dorota, Lityńska Anna, Laidler Piotr
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.991-998, il., tab., bibliogr. 997-998
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Expression of N-cadherin an adhesion molecule of the cadherin family, in tumor cells as associated with their increased invasive potential. Many studies suggested the role of N-linked oligosaccharides as important factors that contribute to metastasis by influencing tumor cell invasion and adhesion. N-cadherin is a heavily glycosylated protein. We have analysed the carbohydrate profile of this protein synthesized inhuman melanoma cell lines: WM35 from the primary tumor site and WM239, WM9, and A375 from different metastatic sits. N-cadherin was immunoprecipitated with anti-human N-cadherin plyclonal antibodies. Characterisation of its carbohydrate moieties was carried out by SDS/PAGE electrophoresis and blotting, followed by immunochemical identification of the N-catherin polypeptides and analysis of their hlycans using highly specifica digoxigenin or biotin labaelled lectins. The positive reaction of N-cadherin from the WM35 cell line with Galanthus nivalis agglutinin (GNA), Datura stramonium agglutinin (DSA) and Sambucus nigra agglutinin (SNA) indicated the presence of high-mannose type glycans and biantennary complex type oligosaccharides with ŕ2-6 linked sialic acid. N-cadherin from WM239, WM9, and A375 cell lines gave a positive reaction with Phaseolus vulgaris leukoagglutinin (L-PHA) and lotus Tetragonolobus purpureas agglutinin (LTA). This indicated the presence of tri- or tetra-antennary complex type glycans with ŕ-fucose. In addition, N-cadherin from WM (lymphomodus metastatic site) adn A375 (solid tumor metastatic site) contained complex type chains with ŕ2-3 sialic acid (positive reaction with Maackia amurensis agglutinin - MAA). The results demonstrated that N-glcans of N-cadherin are altered in metastatic melanomas in a way charakteristic for invasive tumor cells.


    1494/2523

    Tytuł oryginału: Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.
    Autorzy: Sobolewski Krzysztof, Bańkowski Edward, Pałka Jerzy, Jaworski Stefan
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.999-1004, il., bibliogr. s. 1003-1004
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the ubilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an improtant role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associted with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulting them to produce collagen and sulphated glycosaminoglycans.


    1495/2523

    Tytuł oryginału: Inhibition of proteolytic processing of adenoviral proteins by î-amonocaproic acid and ambenum in adenovirus-infected cells.
    Autorzy: Nosach Lidiya, Dyachenko Nataliya, Zhovnovataya Valentina, Lozinskiy Miron, Lozitsky Victor
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.1005-1012, il., tab., bibliogr. s. 1010-1012 - 8 Międzynarodowe Sympozjum nt. molekularnych aspektów chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs î-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.


    1496/2523

    Tytuł oryginału: Report of the 4th Polish-Ukrainian Parnas conference.
    Autorzy: Dzugaj Andrzej, Barańska Jolanta
    Źródło: Acta Bioch. Pol. 2002: 49 (4) s.1053-1054 - 4 Konferencja Polsko-Ukarińska Jakuba Parnasa Wrocław 15-17.09. 2002
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • sprawozdanie
  • tytuł obcojęzyczny

    Temat osobowy:
  • Parnas
  • Jakub


    1497/2523

    Tytuł oryginału: Clinical application of transthoracic Doppler echocardiography to assess coronary flow reserve.
    Tytuł polski: Kliniczne zastosowanie pomiaru rezerwy wieńcowej przy użyciu przezklatkowej echokardiografii dopplerowskiej.
    Autorzy: Dimitrow Petkow
    Źródło: Prz. Lek. 2002: 59 (8) s.629-631, bibliogr. 42 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W poniższej pracy poglądowej omówiono metody (ze szczególnym uwzględnieniem przezklatkowej echokardiografii dopplerowskiej) służące do pomiaru śródbłonkowo-niezależnej oraz śródbłonkowo-zależnej wazodilatacji w zakresie krążenia wieńcowego. Rezerwa wieńcowa jest ważnym parametrem funkcjonalnym dla zrozumienia patofizjologii krążenia wieńcowego. Pomiar rezerwy wieńcowej znajduje zastosowanie w ocenie istotności zwężenia tętnicy nasierdziowej jak również w ocenie mikrokrążenia wieńcowego. W przypadku zwężenia tętniczy wieńcowej, rezerwa wieńcowa jest istotnym parametrem hemodynamicznym ułatwiającym podjęcie decyzji, przykładowo o wykonaniu lub odroczeniu zabiegu PTCA w przypadku granicznego zwężenia tętnicy (40 - 70 proc.). Przy braku zwężeń na poziomie tętnic nasierdziowych, rezerwa wieńcowa może być obniżona w sytuacji, gdy mikrokrążenie wieńcowe jest upośledzone w przebiegu: nadciśnienia tętniczego z i bez przerostu mięśnia sercowego, cukrzyczy, hipercholesterolemii, kardiomiopatii przerostowej, zwężenia zastawki aortalnej lub w zespole X.


    1498/2523

    Tytuł oryginału: The contribution of non-invasive imaging modalities to the diagnosis of left ventricular pseudoaneurysm.
    Tytuł polski: Udział nieinwazyjnych metod obrazowania w diagnostyce tętniaka rzekomego lewej komory.
    Autorzy: Popescu Bogdan A., Ginghina Carmen, Coman Ioan M., Stoian Ioana, Stoica Adina, Stanescu Dan, Georgescu Serban Al., Fotiade Bradu, Apetrei Eduard
    Źródło: Prz. Lek. 2002: 59 (8) s.642-645, il., bibliogr. 14 poz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Left ventricular pseudoaneurysm (LVPA) is a rare entity characterized by a tendency to spontaneous rupture due to its morphology, a lack to myocardial fibers and fibrous tissue delineating the cavity. An early diagnosis is essential in order to guide appropriate therapy. Purpose: To determine the diagnostic accuracy of different imaging techniques, treatment results, and prognosis of patients (pts) with LVPA. Methods: We evaluated the incidence of LVPA during a five-year period. The initial clinical presentation, the etiology of LVPA, time between symptom onset and diagnosis, and use of various non-invasive techniques were studied. Mean follow-up was 15 months. Results: Of 19113 pts admitted to our Institute in a five-year period, LVPA was diagnosed in 11 pts (o.or p.c.) (mean age 51 ń 3.9 years, 8 men). The diagnosis of LVPA was confirmed by surgery in 4 pts, and by pathology in 2 pts. LVPA was and incidental finding in one asymptomatic pt, it was diagnosed in 6 pts presenting with an acute myocardial infarction (AMI) and in 4 pts presenting with LV failure. The main etiology was coronary artery disease (CAD) (9 pts), with the remaining 2 cases being post-traumatic (thoracic stab wound, surgery). LVPA location was postero-inferior in 6 patients infero-lateral in 3 patients, and anterior in 2 patients. ECG, X-ray and TTE were performed in all cases. 6 pts had a radionuclide angiography (RNA), 3 pts had a computed tomography (CT) scan and 2 pts had a magnetic resonance imaging (MRI) study. Two-dimensional transthoracic echocardiography (TTE) provided information regarding LVPA...


    1499/2523

    Tytuł oryginału: Clinical application of 3-dimensional echocardiography.
    Tytuł polski: Zastosowanie kliniczne trójwymiarowej echokardiografii.
    Autorzy: Kasprzak Jarosław D.
    Źródło: Prz. Lek. 2002: 59 (8) s.650-654, il., bibliogr. 42 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Echokardiografia trójwymiarowa jest nową metodą obrazowania serca, umożliwiającąrejestrację i analizę przestrzennych zbiorów danych dotyczących jego struktury. Pozwala ona na dokładną i powtarzalną ocenę anatomii i funkcji serca. Artykuł prezentuje stosowane metody akwizycji, obróbki cyfrowej i prezentacji danych. Omówiono również zastosowanie kliniczne, ograniczenia oraz możliwe kierunki rozwoju tej nowoczesnej metody obrazowania. Najbardziej istotne kierunki praktycznych zastosowań techniki obejmują wspomaganie planowania terapii metodami kardiologii zabiegowej i kardiochirurgii (operacje wypadania płatka zastawki mitralnej, interwencyjne leczenie wad wrodzonych, np. zamykanie ubytku przegrody przedsionków) i ocenę nietypowych patologii jak np. guzy serca. Metoda pozwala także na dokładną ocenę objętości i masy struktur serca. Najistotniejsze etapy ewolucji metody, oczekiwane w niedalekiej przyszłości, to wprowadzenie szybkich, przyjaznych dla użytkownika metod umożliwiających trójwymiarową analizę danych w czasie realnym.


    1500/2523

    Tytuł oryginału: Clinical application of 3-dimensional echocardiography - a 3-year single center experience.
    Tytuł polski: Zastosowanie klinicznej echokardiografii trówymiarowej - doświadczenia 3-letnie.
    Autorzy: Ciesielczyk Michał, Drożdż Jarosław, Krzemińska-Pakuła Maria, Plewka Michał, Zwierzak Marcin, Wierzbowska Karina, Kasprzak Jarosław D.
    Źródło: Prz. Lek. 2002: 59 (8) s.658-662, il., bibliogr. 43 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Echokardiografia trójwymiarowa (3DE) jest nową i szybko rozwijającą się techniką echokardiograficzną. Teoretycznie 3DE powinna mieć zastosowanie w trudnych badaniach, gdy w badaniu dwuwymiarowym (2DE) nie można uzyskać oczekiwanych informacji z powodu złożonych zależności przestrzennych w objętym chorobą sercu lub niemożności uzyskania odpowiedniej płaszczyzny przekroju. Dokładna ocena ilościowa stanowi kolejną zaletę zastosowania 3DE. Metody: W badaniu prezentujemy 3-letnie doświadczenie naszego ośrodka w zastosowaniu 3DE. Retrospektywna analiza bazy danych pozwoliła uzyskać dane 204 badań 3DE. Wszystkie badania zostały przeprwoadzone na aparacie Tom-Tecechoscan 3.1 z zastosowaniem rotacyjnej akwizycji danych. Wyniki: Ogółem wykonano 474 akwizycje obrazów trójwymiarowych. Wskazaniem do wykonania badania 3DE były: ocena funkcji lewej komory serca (51); wady zastawkowe (47); ocena aorty piersiowej (36); guzy serca (22). Jakość uzyskanego obrazu 3D była oceniana w trójstopniowej skali; 0 - zła, 1 - dostateczna, 2 - dobra, 3 - optymalna. Średnia jakość rekonststrukcji 3D wynosiła 2,1 ń 0,8 (w 73 proc. badań uzyskano jakość dobrą lub optymalną). W porównaniu z 2DE, dodatkowe informacje jakościowe lub ilościowe uzyskano u 47 proc. pacjentów; w podziale wg wskazań do badania: w 41 proc. badań funkcji lewej komory serca; w 40 proc. badań wad zastawkowych; w 31 proc. badań aorty piersiowej; w 64 proc. badań wad wrodzonych, w 64 proc. badań guzów serca. Wnioski: 3DE może być zastosowane jako wydajne narzędzie rutynowej diagnostyki kardiologicznej. 3DE jest wartościową techniką w klinicznie uzasadnionych przypadkach, wnosząc dodatkową informację jakościową lub ilościową w 47 proc. badań.


    1501/2523

    Tytuł oryginału: ACL - deficient knee.
    Tytuł polski: Kolano bez więzadła krzyżowego przedniego.
    Autorzy: Adamczyk Grzegorz
    Źródło: Acta Clin. 2002: 2 (1) s.11-16, il., tab., bibliogr. 29 poz., streszcz.
    Sygnatura GBL: 313,595

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Unaczynienie WKP pochodzi w większości od tętnicy środkowej kolana, jak również z gałązek końcowych tętnic dolnych kolana przyśrodkowej i bocznej. Większość ukrwienia dociera z tylno-górnej okolicy przyczepu udowego. Naczynia krwionośne rozgałęziają się w błonie maziowej formując oplatającą więzadło sieć, która tworzy osłonkę odżywczą. Naczynia te komunikują się z siecią naczyń wewnątrzwięzadłowych. Połączenia więzadła z kością nie uczestniczą w zaopatrzeniu WKP w krew. Ponad 1.5 proc. WKP stanowią nerwy. W więzadle stwierdza się 44 typy mechanoreceptorów, pomiędzy nimi są np. wolne zakończenia nerwowe, które inicjują ochronne napięcie mięśni już w 53 msek. po urazie, podczas gdy w kolanie pozbawionym WKP ta reakcja jest opóźniona o około 200 msek. WKP jest więc bardzo ważnym ogniwem w szlakach czucia głębokiego, jego impulsacja pełni podstawową rolę w regulacji odruchowego napięcia mięśni zapewniającego kontrolę stabilności kolana w mechanizmach tzw. kontrakcji mięśniowej. Większość pacjentów po uszkodzeniu WKP zmienia stereotyp chodu, by uniknąć przedniego podwichnięcia piszczeli, które nasila się przy skurczu mięśnia czworogłowego (przy kącie 15 - 25ř podwichnięcie jest największe) i rozwija chód z unikaniem jego aktywności. Nie leczone uszkodzenie WKP prowadzi do przedniej niestabilności stawu kolanowego, a w konsekwencji do uszkodzenia łąkotek a następnie degeneracji chrząstki stawowej. U młodych i aktywnych pacjentów postęp choroby jest bardzo szybki, w grupie ...

    Streszczenie angielskie: Anterior cruciate ligament (ACL) acts as a main restraint of anterior translation of the tibia. ACL is intrasynovial but extraarticular, because it reflects synovium from posteror capcule of the knee joint and is synovial fold that serves as a main source of nutrition and vascularisation for ACL. Part of ACL tear may spontaneously heal inside the synovial coverage. Ligament is highly innervated, more than 1,5 p.c. of its volume is constituted by nerve endings, 4 types of receptors are detected inside the ACL, mainly in approximity of bone attachments. ACL serves as a main tract for proprioceptive reactions. In the knee joint ACL is gradually loaded as the knee extends. In the absence of sufficient coactivation from the hamstrings, the posterior pull they apply to the proximal tibia is not avaiable leaving the ACL as the sole structure to stabilize the joint. Latency of neuromuscular control of deformity in healthy individuals is 53 ms and among the ACL - deficient individuals letency is about 200 ms. In the absence of ACL patients tend to develop a quadriceps-avoidance gait to reduce a quadriceps contraction during walking and finally loose about 10 p.c. of quadriceps muscle strongth. Untreated ruptures lead to anterior laxitty and subsequent meniscal tears in a great majority of cases, but about 1/3 patients in a long-term may be asymptomatic, and 47 p.c. may for some time returned to amateur sport. Meniscal tears are observed among 86 p.c. patients with an ACL ...


    1502/2523

    Tytuł oryginału: Anterior cruciate ligament reconstruction using hamstrings in press-fit technique without hardware.
    Autorzy: Paessler H. H.
    Źródło: Acta Clin. 2002: 2 (1) s.40-45, il., bibliogr. 7 poz.
    Sygnatura GBL: 313,595

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • transplantologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1503/2523

    Tytuł oryginału: New techniques for anterior cruciate ligament revision surgery.
    Autorzy: Paessler H. H., Mastrokalos D. S., Motsis E. K.
    Źródło: Acta Clin. 2002: 2 (1) s.48-60, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,595

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Similar to the development in joint replacement surgery, revision surgery is becoming more and more important in Anterior Cruciate Ligament (ACL) surgery. Localistaion and volume of previous tunnels are crucial for planning revision surgery. Based on these different tunnel conditiones, a new grading system has been developed indicating the difficulty of the upcoming revision surgery. Evaluation of our more than 500 cases of ACL revision surgery demonstrated in 74 p.c. malposition of the previous bone tunnels as the reason for graft failure and revision. Severely abnormal tunnel position allows in generally for new tunnel drilling in the correct position (Grade 1 revision). Isolated tibial tunnel dilation is seen mainly following ACL reconstruction using bone-patellar tendon-bone grafts (BPTB). In most of these cases the femoral tunnell is obliterated by the bone block of the BPTB (Grade II). In these cases, bone grafting of the tibial tunnel alone is frequently neccessary. Severe dilation of both the tibial and femoral tunnels are seen mainly following ACL reconstruction using hamstring with graft fixation far away from the anatomical side (Grade III). In these cases bone grafting of the both old and drilling of new tunnels in the correct positon as a one stage procedure might be a possible solution. On the tibial side the tunnels may be positioned or dilated too far anteriorly and/or posteriorly or medially. In some instances the opening of the old tunnel by osteotomy may be the safest approach for revision, especially if the old graft is still ...


    1504/2523

    Tytuł oryginału: Posterior cruciate ligament injuries and its treatment.
    Tytuł polski: Uszkodzenia więzadła krzyżowego tylnego i jego leczenie.
    Autorzy: Adamczyk Grzegorz
    Źródło: Acta Clin. 2002: 2 (1) s.62-76, il., tab., bibliogr. 30 poz., streszcz.
    Sygnatura GBL: 313,595

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Więzadło krzyżowe tylne (WKT) jest strukturą anatomiczną stanowiącą główny ogranicznik tylnego przemieszczenia kości piszczelowej względem kości udowej. Funkcjonalnie można je podzielić na kilka części, z których najważniejsze są: pęczek przednio-boczny i pęczek tylno-przyśrodkowy. Pęczek przednio-oczny napina się przy kolanie zgiętym do 90ř, tylno przyśrodkowy przy kolanie zgiętym do 30ř. WKT ma 38 mm długości, około 13 mm średnicy, jest położone wewnątrzstawowo, ale na zewnątrz błony maziowej, którą wpukla od tyłu do stawu tak, że tworzy ona grubą warstwę synowialną przykrywającą WKT z 3 stron. Dodatkowymi elementami tylnego kompleksu więzadłowo-torebkowego stawu kolanowego są więzadła łąkotkowo-udowe przednie (Humphreya) i tylne (Wrisberga). Więzadło Wrisberga rozpoczyna się na rogu tylnym łąkotki bocznej, tylnym brzegu kości piszczelowej, przechodzi skośnie i ku tyłowi od WKT i ma swój osobny końcowy przyczep na kości udowej, może mieć grubość do 50 proc. WKT, przeciętnie 20 proc. Więzadło przednie Humphreya zaczyna się na rogu tylnym łąkotki bocznej, przebiega wzdłuż przedniego brzegu WKT i przyczepia do kłykcia przyśrodkowego kości udowej. Przy uszkodzonym WKT więzadła te mają pewne znaczenie w redukowaniu objawu szuflad tylnej. WKT jest grubsze od WKP, ale jego parametry mechaniczne u ludzi młodych obciążenia końcowe - 1627 ń 491N i sztywność liniowa - 204 ń 66 N są zbliżone do WKP, wg Harnera pączek przednio-boczny ma 2,5x wiekszą wytrzymałość niż ...

    Streszczenie angielskie: Posterior cruciate ligament is a main restraint of posterior translation of tibia. PCL acts primaliry as two functional separate bundles, with anterolateral portion acting predominantly in flexion and a posteromedial acting predominantly in extension. The linear stiffnes of the anterolateral bundle is 2,5 times greater than that of the posteromedial bundle and menisco-femoral ligaments. The strength and stiffness of the anterolateral component of PCL has significant implication for ligament recopnstruction. PCL is a main component of functional entity of posterolateral anatomical structures of the knee joint composed of two parts: posterolateral complex of the knee in terms of teh superficail lateral collateral ligament and "deep ligament complex", which include the arcuate ligament, popliteus tendon, fabellofibular ligament and the posterolateral capsule - so called posterior complex ligaments. The main mechanisms are high velocity injuries, e.g. hyperextension or fall on flexed knee and direct trauma of proximal tibia. Incidence of PCL injury is reported to be from 1 - 40 p.c. of acute knee injuries, in 42 p.c. of patients with haemarthrosis occurs PCL lesions. A total of 45,9 p.c. of PCL injuries were combined ACL/PCL tears, 41,2 PCL/PLC tears and only 3 p.c. were isolated PCL tears. The base of diagnosis is a clinical ivestigation, and the most accurate clinical test to evaluate the PCL injury is the posterior drawer at 90ř of flexion performed with the patient ...


    1505/2523

    Tytuł oryginału: The future of knee ligament surgery.
    Autorzy: Fu Freddie H., Musahl Volker
    Źródło: Acta Clin. 2002: 2 (r1) s.101-107, bibliogr. 50 poz.
    Sygnatura GBL: 313,595

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Approximately 100,000 anterior cruciate ligament (ACL) reconstructions are being performed every year in the United States alone. Long-term clinical outcome can still not exceed 85 - 90 p.c. as a result of biological, biomechanical, and technical reasons. Biological incorporation of grafts in bone tunnels (bone-to-bone and bone-to-tendon healing) is still not completely understood and is currently subject of basic since research. Knowledge on in situ forces and in vivo strains in the ACL are the basis of rehabilitation regimens. Ultimately, healing and remodeling of the ACL graft needs to be improved. Gene therapy can be applied to the field of Orthopaedic surgery by transfer of defined genes encoding for growth factors into tareget tissues (e.g. ligamnet, cartilage or bone). Local cells at injury sites can then highly and persistently produce therapeutic proteins. Gene transfer techniqes in animal models have shown promising first results when enhancing graft incorporation. In addition, Computer Assisted Orthopaedic Surgery (CAOS) is now considered to add further precision and accuracy to knee ligament surgery. Passive and active systems are thereby distinguished. In the future, a simple muscle biopsy may be enough to provide the cell that can restore any kind of defect in the knee by growing the local cell line. With improved medical imaging techniques and surgical robotics, clinical outcome may be improved.


    1506/2523

    Tytuł oryginału: Experimental nail infection with pathogenic fungi.
    Tytuł polski: Doświadczalne zakażenie paznokci grzybami patogennymi.
    Autorzy: Macura Anna B., Pawlik Bolesław, Perun Magdalena
    Źródło: Mikol. Lek. 2002: 9 (4) s.179-183, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,181

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie: Dermatofity, grzyby drożdżopodobne z rodzaju Candida oraz niektóre gatunki grzybów pleśniowych mogą atakować paznokcie, powodując grzybice paznokci. Cel pracy: Celem pracy była ocena podatności stóp i rąk osób zdrowych na zkażenie grzybami, które najczęściej wywołują grzybicę paznokci. Materiał i metody: Paznokcie pochodziły od 30 zdrowych osób (18 kobiet i 12 mężczyzn) w wieku od 8 do 85 lat. Dystalne fragmenty płytek paznokciowych po rozdrobnieniu i sterylizacji były zakażone 6 szczepami grzybów (T. mentagrophytes, T. rubrum, C. albicans, C. parapsilosis, A. flavus, S. brevicaulis) wyizolowanymi obficie z paznokci pacjentów z grzybicą paznokci. Zakażenia dokonywano osobno dla paznokci stóp i rąk odpowiednio przygotowanym inokulum, zawierającym 5 x 10**7 form tworzących kolonie w 1 mililitrze, prowadząc inkubację w temp. 27řC przez 14 dni dla dermatofitów i przez 7 dni pozostałych grzybów. Efektywność zakażenia oceniano w preparatach bezpośrednich rozjaśnionych, na podstawie obserwacji strzępek grzybni wnikających do fragmentów paznokci. Wyniki: Podatność paznokci pochodzących od tych samych osób na zakażenie poszczególnymi grzybami była różna. W części przypadków wogóle nie doszło do zakażenia, a w części ulegały bardzo intensywnemu zakażeniu innym grzybem. Stwierdzono wyższą podatność na zakażenie grzybicze paznokci stóp niż rąk. Paznokcie stóp ulegały najbardziej intensywnemu zakażeniu szczepem S. brevicaulis (60 proc.), T. mentagrophytes (53,2 proc.), T. rubrum (50 proc.) oraz C. albicans (43,4 proc.). Paznokcie rąk ulegały tak intensywnemu zakażeniu szczepem T. mentagrophytes i T. rubrum (po 40 proc.) oraz S. brevicaulis (36,7 proc.) i C. Albicans (33,2 proc.).


    1507/2523

    Tytuł oryginału: The imaging of onychomycosis using digital epiluminescence microscopy.
    Tytuł polski: Obraz grzybicy paznokci w cyfrowej mikroskopii epiluminescencyjnej.
    Autorzy: Ratka Małgorzata, Ratka Wojciech, Popik Małgorzata
    Źródło: Mikol. Lek. 2002: 9 (4) s.185-188, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,181

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy była ocena przydatności cyfrowej mikroskopii epiluminescencyjnej w diagnostyce grzybicy paznokci. Cyfrowa mikroskopia epiluminescencyjna jest układem złożonym z mikroskopu z wbudowanym źródłem spolaryzowanego światła widzialnego oraz komputera. W przypadku grzybicy paznokci urządzenie to pozwala na wykrycie, bardzo często nieuchwytnych w standardowym badaniu klinicznym, a patognomonicznych dla infekcji dermatofitowej, objawów siatki poprzecznej lub gałązkowej. Umożliwia to, mimo ujemnych badań mikologicznych, wczesne wdrożenie leczenia przeciwgrzybiczego. Badanie przeprowadzane jest in vivo i jest całkowicie bezinwazyjne. Przebadano 44 pacjentów z grzybicą dermatofitową paznokci u których występował objaw siatki. Siatkę poprzeczną stwierdzono w 21 przypadkach (47,8 proc.), gałązkowatą w 6 (13,6 proc.), a jednocześnie poprzeczną i gałązkowatą w 17 (38,6 proc.). Najczęstszą postacią grzybicy była DLSO - 30 przypadków (68,2 proc.), następnie SO - 11 (25 proc.) i TDO - 3 (6,8 proc.). Cyfrowa mikroskopia epiluminescencyjna dodatkowo umożliwia prowadzenie dokładnej dokumentacji oraz pozwala na monitorowanie przebiegu i skuteczności leczenia grzybicy paznokci.


    1508/2523

    Tytuł oryginału: Investigation of essential oil from Cirsium rivulare (Jacq.) All. flowers.
    Tytuł polski: Badania olejku eterycznego z kwiatostanów Cirsium rivulare (Jacq.) All. flowers.
    Autorzy: Nazaruk J[olanta], Góra J., Majda T., Gudej J[an]
    Źródło: Herba Pol. 2002: 48 (4) s.193-197, il., tab., bibliogr. 5 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Celem pracy była analiza fitochemiczna olejku eterycznego z kwiatostanów ostrożenia łąkowego Cirsium rivulare (Jacq.) All. metodą GC i GC MS. Olejek otrzymano podczas destylacji z parą wodną świeżego surowca w aparacie Derynga, z wydajnością 0,05 proc. w przeliczeniu na suchą masę. Dominującymi składnikami olejku były kwasy tłuszczowe i węglowodory. Oprócz tego stwierdzono obecność monoterpenów (á-ocymen, limonen, á-pinen) i seskwiterpenów (tlenek á-karioflenu).

    Streszczenie angielskie: The aim of this study was phytochemical investigation of essential oil from Cirsium rivulare (Jacq.) All. flowers by GC and GC-MS method. Essential oil was obtained by hydrodistillation from fresh source in Deryng's apparatus with yield 0,05 p.c. in count over dry plant material. The dominannt constituents were fatty acids and carbohydrates. Moreover found monoterpens (á-ocimene, limonene, á-pinene) and sesquiterpenes (á-caryphyllene oxide).


    1509/2523

    Tytuł oryginału: Sterole i triterpeny w kwiatach Pyrus communis L.
    Tytuł angielski: Sterols and triterpenes in Pyrus communis L. flowers.
    Autorzy: Rychlińska I[zabela], Gudej J[an]
    Źródło: Herba Pol. 2002: 48 (4) s.198-205, il., tab., bibliogr. 15 poz., sum. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Z kwiatów gruszy dziko rosnącej za pomocą chromatografii kolumnowej wyizolowano kwas ursolowy. Jego strukturę potwierdzono metodami spektralnymi (IR, NMR). Inne triterpeny i sterole badano metodą TLC, GC, GC/MS we frakcjach otrzymanych z wyciągu benzynowego i chloroformowego z kwiatów gruszy. Z triterpenów zidentyfikowano kwas oleanowy, ursolowy, ŕ-amyrynę, neooleandien; ze steroli á-sitosterol i sacharosten. Porównano chromatograficznie (TCL) zespół steroli i triterpenów występujących w kwiatach gruszy dzikiej z z espołem steroli i triterpenów w kwiatach wybranych odmian hodowlanych. W badanych surowcach zespół wyżej wymienionych związków był jakościowo identyczny.

    Streszczenie angielskie: Using column chromatography ursolic acid was isolated from flowers of naturally growing Pyrus communis L. Its structure was determined by spectroscopic methods (IR, NMR). Other sterols and triterpenes in fractions obtained form benzine and chloform extracts from flowers of naturally growing Pyrus communis were examined using TLC, GC, GC/MS methods. Following triterpens were identified: oleanolic acid, ursolic acid, ŕ-amyrin and neoolenadiene, as well as sterols á-sitosterol i saccharostenose. The compositions of triterpene and sterolic fractions from flowers of naturally growing Pyrus communis and from flowers of cultivated varieties were compared chromatographically (TLC). Those compositions turned out to be similar.


    1510/2523

    Tytuł oryginału: Sterols in the roots and herb from Hieracium pilosella L.
    Tytuł polski: Sterole w korzeniach i zielu Hieracium pilosella L.
    Autorzy: Krzaczek T[adeusz], Łukasiewicz E., Gawrońska-Grzywacz M.
    Źródło: Herba Pol. 2002: 48 (4) s.206-209, il., tab., bibliogr. 12 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Metodą GCMS przeprowadzono porównawcze badania obecności steroli w korzeniach i zielu H. pilosella. W obu badanych frakcjach zidentyfikowano á-sitosterol, stigmasterol, kampesterol oraz ŕ-saccharostenon. Stigmast-7-en-3-ol stwierdzono tylko w zielu a stigmast-4-en-on tylko w korzeniach. Sitosterol i stigmasterol były związkami dominującymi w obu surowcach. Metodą wagową określono całkowitą ilość steroli w zielu (0,24 proc.) oraz w korzeniach (0,16 proc.).

    Streszczenie angielskie: A comparative study of the sterol components of roots and herb of H. pilosella was carried out using GCMS techniques. á-sitosterol, stigmasterol, campesterol and ŕsaccharostenon were identified in both fractions. Stigmast-7-en-3-ol was identified only in herb and stigmast-4-en-3-on only in roots. Sitosterol and stigmasterol were the the predominant sterol comnenets in analysed raw materials. Besides, by means of the weight method the total amounts of sterols was determined: in herb 0,24 p.c. and in roots 0,16 p.c.


    1511/2523

    Tytuł oryginału: Sterols in the the herb and rhizomes from Comarum palustre L.
    Tytuł polski: Sterole w zielu i kłączach Comarum palustre L.
    Autorzy: Sokołowska-Woźniak A[nna], Krzaczek T[adeusz], Białopiotrowicz Ł., Gawdzik J., Mardarowicz M.
    Źródło: Herba Pol. 2002: 48 (4) s.210-213, il., tab., bibliogr. 6 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Z ekstraktu eteru naftowego z ziela i kłącza C.palustre w typowy sposób wyodrębniono frakcję octanów steroli. Metodą wagową określano całkowitą ilość steroli w zielu (0,1192 proc.) i kłączu (0,0517 proc.) w 100 g surowca. Skład mieszaniny steroli badano metodą kapilarnej chromatografii gazowej. W obu badanych frakcjach stwierdzono występowanie: stigmasterolu, á-sitosterolu, kampesterolu i ergosterolu. Stigmasterol i á-sitosterol były związkami dominującymi w zielu i kłączach C. palustre.

    Streszczenie angielskie: The fraction of sterols acetates from the herb and rhizomes from C. palustre have been isolated in the typical way from petrolum ether extract. By means of the weight method the total amounts of sterols was determined in herb (0.1192 p.c.), in rhizomes (0.0517 p.c.) . The mixture of sterols acetates was investigated by capillary gas chromatography GC MS techniques. Stigmasterol, á-sitosterol, campesterol and ergosterol were identified in both fractions. Stigmasterol and ásitosterol were the predominant sterol components in analysed raw materials from c. palustre.


    1512/2523

    Tytuł oryginału: Phenolic acids from Cydonia japonica Pers.
    Tytuł polski: Kwasy fenolowe w Cydonia japonica Pers.
    Autorzy: Sokołowska-Woźniak A[nna], Szewczyk K, Nowak R[enata]
    Źródło: Herba Pol. 2002: 48 (4) s.214-218, tab., bibliogr. 11 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Metodą dwukierunkowej chromatografii cienkowarstwowej (2D-TLC) oraz wysokosprawnej chromatografii cieczowej (HPLC) analizowano zespółfenolokwasów z owocni, nasion i liści C. japonica. Zidentyfikowano czternaście fenolokwasów. Dominującymi kwasami w badanych surowcach były: kawowy, protokatechowy, galusowy, p-hydroksybenzoesowy, p-kumarowy, syryngowy i wanilinowy. Zawartość poszczególnych kwasów w badanych frakcjach była zróżnicowana. W liściach kwasy występowały w największej ilości, zwłaszcza kwas kawowy - 266,25 ćg/g, i kwas protokatechowy - 123,80 ćg/g.

    Streszczenie angielskie: Phenolic acids from pericarps, seeds and leaves in the C. japonica were analysed by means of two dimensional thin layer chromatography and RP-HPLC methods. The fourteen acids were identified. The following phenolic acids predominated in all the examined material: caffeic, protocatechnic, gallic, p-hydroxybenzoic, p-coumaric, ferulic, syringic, vanilic. The content of nine major phenolic acids was described. In leaves acids occurred in the greatest content, especially caffeic (266.25 ćg/g) and the protocatechuic acid (123.80 ćg/g).


    1513/2523

    Tytuł oryginału: The determination of the lipophilic parameters of phenolic acids by chromatographic and spectrophotometric methods.
    Tytuł polski: Wyznaczanie parametrów lipofilności kwasów fenolowych metodą chromatograficzną i kinetyczną metodą spektrofotometryczną.
    Autorzy: Persona A., Smolarz H. D., Fekner Z.
    Źródło: Herba Pol. 2002: 48 (4) s.219-224, il., tab., bibliogr. 12 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Lipofilność serii kwasów fenolowych była wyznaczana przy zastosowaniu dwóch różnych technik pomiarowych: TLC na płytkach celulozowych z fazami ruchomymi zawirającymi mieszaninę metanolu i wody oraz 1 proc. i 5 proc. dodatek kwasu octwoego i spektrofotometryczną metodą kinetyczną. Stwierdzono dobrą korelację pomiędzy lipofilnością wyznaczoną eksperymentalnie a wartościami obliczonymi teoretycznie. Sugeruje to, że równania krzywych RMW vs. log Ptau lub RMW vs. PMW vs. log Pteoret dla kongenerycznej grupy związków mogą być wykorzystane do oszacowania lipofilności badanych substancji już na poziomie chromatograficznego rozdziału ekstraktów roślinnych.

    Streszczenie angielskie: The lipophilicity of series of phenolic acids has been determined by two experimental techniques: TLC of commercial cellulose plates with methanol-water-acetic acid as mobile phase, and spectrophotometric UV/VIS kinetic method. These results were compared with theoretical calculations according Broto's, Viswandhan's and Crippen's methods. Obtained results shown good correlation between lipophilicity determined by use experimental techniques and theoretically calculated values. It suggest that calibration equations RMN vs. logPtheoret for congeneric series of compounds may be used for estimation of liphophilicity investigated compounds (logP0 just on the stage of their chromatographic separation in plant extracts.


    1514/2523

    Tytuł oryginału: Optimization of a measurement of flavonol aglycones in some medicinal plants by SPE-RP-HPLC method. P. 1: Analysis of standard aglycones mixture stability in different hydrolysis conditions.
    Tytuł polski: Optymalizacja oznaczania aglikonów flawonolowych metodą SPE-RP-HPLC w niektórych ekstraktach roślinnych.
    Autorzy: Nowak R[enata]
    Źródło: Herba Pol. 2002: 48 (4) s.225-232, il., tab., bibliogr. 12 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Celem pracy była optymalizacja metody oznaczania flawonoli w ekstraktach roślinnych. W pierwszym etapie badano wpływ stosowanych warunków warunków hydrolizy na stabilność i detekcję aglikonów flawonowych. Wykazano, między innymi, dużą trwałość większości wzorcowych aglikonów flawonolowych podczas ogrzewania w środowisku kwasowym oraz znaczący wpływ środowiska reakcji (rodzaju i stężenia kwasu) na wysokość i pole powirzchni analizowanych związków. Wskazano na potrzebę stosowania w analizie ilościowej roztworów substancji wzorcowych o pH zbliżonym do pH analizowanych hydrolizatów oraz na możliwość otrzymania zafałszowanych wyników podczas zastosowania kwasu siarkowego do hydrolizy badanego ekstraktu.

    Streszczenie angielskie: The aim of this examination was optimization of flavonols' detection method in plant's extracts. In the first stage of the research the analysis of standard aglycones mixture stability in different hydrolysis conditions was performed. It was shown, among others, that most of the flavonols aglycones presented high durability during heating with acid. Moreover, the significant impact of acidity of environment of the reaction (acid's kind and concentration) on the height and surface area of analyzed compounds was observed. These facts indicate the necessity of using in quantitative analysis solutions of standards of pH similar to pH of analyzed hydrolyzates. Also the possibility of obtaining incorrect results while using sulfuric acids as hydrolytic medium of the examined extracts was shown.


    1515/2523

    Tytuł oryginału: The effect of metal ions action on volatile oil content and composition in medicinal plants from Umbelliferae family.
    Tytuł polski: Wpływ jonów metali na zawartość i skład olejku eterycznego w roślinach leczniczych z rodziny Umbelliferae.
    Autorzy: Wierzchowska-Renke K[rystyna], Ochocka J. R., Głowniak K[azimierz], Marek D., Jańczyk J.
    Źródło: Herba Pol. 2002: 48 (4) s.233-241, il., tab., bibliogr. 12 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: W pracy omówiono reakcje roślin z rodziny Umbelliferae wywołane przez oddziaływanie na nie jonów Ti, Mn i Cu. Materiałem badanym były: Crithmum maritimum L. - rośliny nawożone dolistnie 0,04 proc. roztworem Tytanitu (Ti stanowi jego główny składnik), Pastinaca sativa L. - stresowany przez 24, 48 i 72 godziny roztworami Cu, mieszaniną roztworów Cu + Mn i tytanitem (0,04 proc. i 0,4 proc.) oraz Peucedanum verticillare Koch, srtresowany roztworami jonów Cu i Cu + Ti (24, 48 i 72 godziny). Stwierdzono, że na zawartość olejku i jego skład w roślinach poddanych działaniu wyżej wymienionych jonów metali wpływa szereg czynników, takich jak stężenie i rodzaj roztworu stresującego, sposób jego podania (np. dolistne), czas ekspozycji oraz wiek roślin narażonych na stres. Reakcja poszczególnych gatunków była odmienna.

    Streszczenie angielskie: We describe the reaction of Umbeliferae family plants caused by Ti, Mn and Cu ions application. The studied material was: Crithmum maritimum L. after fertilization with 0.04 Tytanit (Ti main component) formula on the leaves Pastinaca staiva L. stressed with Cu and Cu + Mn and Tytanit (0.04 p.c. and 0.4 p.c.) for 24, 48 and 72 h, Peucedanum verticillare Koch, stressed with Cu and Cu + Ti (24, 48 and 72 h). The volatile oils content and compositum in plants stressed with metal ions solutions depends on many factoprs. Among them one should mention the method of application (leaves' fertilization, direct effect), their concentrations, the time of exposition and age of plants exposed to the stress. The reaction of particular plant species to the experimental stress varied.


    1516/2523

    Tytuł oryginału: Centella asiatica (L.) Urban cultured in vitro - the effect of Zn and Ti ions application on growth of plantlets and accumulation of selected elements.
    Tytuł polski: Centella asiatica (L.) Urban w hodowli in vitro - ocena efektu działąnia jonów Zn i Ti na wzrost roślin i gromadzenie przez nie niektórych pierwiastków.
    Autorzy: Wierzchowska-Renke K[rystyna], Guzewska J., Furmanowa M., Ochocka J. R., Oklejak M., Dorosz A., Wróbel M.
    Źródło: Herba Pol. 2002: 48 (4) s.261-269, il., tab., bibliogr. 16 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: W prezentowanej pracy omówiono w jaki sposób abiotyczne czynniki stresogenne, takie jak jony Zn i Ti, działają na wzrost Centella asiatica (L.) Urban (Apiaceae) oraz na gromadzenie przez nie niektórych pierwiastków. Rośliny hodowawano na pożywkach Nitsch i Nitsch (NN) lub Schenk i Hildebrandt (SH) z różnymi regulatorami wzrostu. Jony Zn w postaci ZnSO4 w 4 stężeniach dodawano do pożywki na 3 do 7 tygodni. Jony tytanu zawarte w nawozie dolistnym - Tytanicie, dodawano do pożywki lub rośliny zanurzano w 0,04 proc. roztworze, a następnie płukano lub nie w wodzie. Oznaczano zawartość form "wolnych" (rozpuszczalnych w wodzie) i "związanych" (w strukturach komórkowych) wybranych biopierwiastków: Cu, Mn, Zn, Fe, Ca and Mg metodą ASA stosując spektrofotometr SP 1900 Pye Unicam. Przeprowadzone obserwacje wykazały, że podanie jonów cynku i tytanu wpływa nie tylko na wzrost i rozwój C. asiatica w hodowli in vitro, lecz także wywołuje zmiany w jej składzie mineralnym. W badanych próbach stwierdzono znaczne różnice w zawartości oznaczanych pierwiastków (Cu, Zn, Mn, Fe, Mg, Ca). Na poziom ich oddziaływała nie tylko ilość Zn dodanego do pożywki, czy forma podania jonów tytanu, lecz także czas ekspozycji.

    Streszczenie angielskie: The aim of the work was to find how the abiotic stress factors, such as Zn and Ti ions, influenced on growth factor and accumulation of some elements in plantlets of C. asiatica (L.) Urban (Apiaceae). Plantlets were cultured on Nitsch and Nitsch (NN) or Schenk and Hildebrandt (SH) modified media with various growth regulators. Zn ions as ZnSO4 were additionaly put into medium in 4 concentrations for 3 to 7 weeks. Ti ions as 0.04 p.c. solution of Tytanit - foliar fertilizer were added into medium or stems of plantlets were soakink in solution only or with subsequent rinsing in sterile water. The concentrations of selected biolelments: Cu, Mn, Zn, Fe, Ca, and Mg (determined by ASA using Spectrophotometer SP 1900 Pye Unicam in "free" (soluble in water) and "bound" (in cell structure) forms were evaluated. The observations have shown tha Zn and Ti application influenced on the weight and development of Centella asiatica cultured in vitro and caused changes in their mineral composition. Important differences in concentration of evaluated elements were found in studied samples. The content of analysed bioelements was dependent not only on Zn concentration in the medium but also of the form of Ti application or of the duration of the experiment.


    1517/2523

    Tytuł oryginału: Effect of 10-day treatment with Padma 28 on the serum ŕ-fetoprotein and á2-microglobulin levels in rats pretreated with subacute intoxication of cadmium chloride.
    Tytuł polski: Wpływ 10-dniowego podawania Padmy 28 na stężenie ŕ-fetoproteiny i á2-mikroglobuliny w surowicy krwi szczurów poddanych podostremu zatruciu chlorkiem kadmu.
    Autorzy: Jagiełło-Wójtowicz E[wa], Jeleniewicz K[rystyna], Chodkowska A[nna]
    Źródło: Herba Pol. 2002: 48 (4) s.270-273, il., bibliogr. 14 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Celem tej pracy było zbadanie wpływu 10-dniowego podawania Padmy 28 na stężenie ŕ-fetoproteiny (AFP) i á2-mikroglobuliny w surowicy krwi szczurów poddanych 14-dniowemu zatruciu chlorkiem kadmu. Wykazano, że podostre zatrucie szczurów kadmem poduje istotne zwiększenie stężenia AFP i á2-mikroglobuliny w surowicy krwi. Padma 28 stosowana przez 10 dni zmniejszała stężenie AFP i á2-mikroglobuliny w surowicy krwi szczurów zatrutych chlorkiem kadmu. Wydaje się, że Padma 28 może wykazywać ochronne działanie w podostrym zatruciu kadmem u szczurów.

    Streszczenie angielskie: The aim of the study was to investigate the effect of 10-day treatment with Padma 28 on the levels of ŕ-fetoprotein (AFP) and á2-microglobulin in the serum of cadmium-poisoned rats. It was found that subacute intoxication with cadmium chloride significantly enhanced AFP and á2-microglobulin levels in the serum of cadmium-poisoned rats in comparison with the group receiving cadmium only. The data presented here indicated protective action of Padma 28 in cadmium-poisoned rats.


    1518/2523

    Tytuł oryginału: Effects of chelidonine and Ukrain on the activity of serum ALT and AST in rats intoxicated by copper chloride.
    Tytuł polski: Wpływ chelodoniny i leku Ukrain na aktywność aminotransferaz (ALT i AST) w surowicy krwi szczurów zatrutych chlorkiem miedzi.
    Autorzy: Jagiełło-Wójtowicz E[wa], Izdebska M., Piątkowska-Chmiel I.
    Źródło: Herba Pol. 2002: 48 (4) s.274-277, il., bibliogr. 9 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Celem tej pracy była ocena 10-dniowego stosowania chelidoniny lub leku Ukrain na aktywność AST i ALT w surowicy krwi szczurów poddanych ostremu zatruciu chlorkiem miedzi. Wykazano, że ostre zatrucie miedzią prowadzi do wzrostu aktywności obu aminotransferaz w porównaniu z grupą kontrolną. 10-dniowe stosowanie chelidoniny (50,0 i 100,0 mg/kg i.p.) lub leku Ukrain (7,0 i 14,0 mg/kg i.p.) zwiększało istotnie aktywność AST oraz ALT (tylko Ukrain w dawce 7,0 mg/kg i.p.) w surowicy krwi szczurów zatrutych chlorkiem miedzi. Uzyskane wyniki wskazują, że zarówno chelidonina jak i Ukrain zwiększają aktywność aminotransferaz w surowicy krwi szczurów zatrutych chlorkiem miedzi i nie wykazują działania ochronnego.

    Streszczenie angielskie: In this study we have investigated the effects of 10-day treatment with chelidonine or Ukrain on the activities of aminotransferases (ALT and AST) in the serum of copper-poisoned rats. It was found that the acute copper chloride poisoning significantly enhanced AST and ALT activity in serum of rats in comparison in the control group. 10-day treatment with chelidonine (50.0 and 100.0 mg/kg i.p.) or Ukrain (7.0 and 14.0 mg/kg i.p.) significantly increased the activity of AST and ALT (only for Ukrain in a dose of 7.0 mg.kg) in the serum of copper-poisoned rats in comparison with the group receiving cooper chloride only. The results indicate that 10-day treatment with chelidonine or Ukrain increased the activities of aminotransferases in serum of copper-poisoned rats and did not affect the protective changes.


    1519/2523

    Tytuł oryginału: Effects of chelidonine and Ukrain on the activity of minotransferases in serum of rats intoxicated by tin chloride.
    Tytuł polski: Wpływ chelidoniny i leku Ukrain na aktywność aminotransferaz w surowicy krwi szczurów zatrutych chlorkiem cyny.
    Autorzy: Jagiełło-Wójtowicz E[wa], Piątkowska-Chmiel I., Chodkowska A[nna], Izdebska M.
    Źródło: Herba Pol. 2002: 48 (4) s.278-281, il., bibliogr. 8 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Celem pracy była ocena wpływu 10-dniowego podawania chelidoniny i leku Ukrain na aktywność ALT i AST w surowicy krwi szczurów poddanych ostremu zatruciu chlorkiem cyny. Stwierdzono, że ostre zatrucie cyną zwiększało aktywność obu aminotransferaz w porównaniu z grupą kontrolną. 10-dniowe podawanie chelidoniny (tylko w dawce 100.0 mg.kg i.p.) zwiększło istotnie aktywność AST i pozostawało bez wpływu na aktywność ALT w surowicy krwi szczurów poddanych ostermu zatruciu cyną. Natomiast 10-dniowe stosowanie leku Ukrain (tylko w dawce 14,0 mg.kg i.p.) zwiększało istotnie aktywność AST i zmniejszało aktywność ALT w surowicy krwi szczurów poddanych ostremu zatruciu chlorkiem cyny.

    Streszczenie angielskie: The aim of the presented paper was to investigate the effects of chelidonine or Ukrain on the activity of serum aminotransferases AST and ALT in serum of tin-poisoned rats. The acute administration of tin chloride significantly increased AST and ALT activity in serum of rats in comparison in the control group. 10-day treatment with chelidonine (only in a dose of 100.0 mg/kg i.p.) significantly enhanced the activity of AST and did not affect the activity of ALT in the serum of tin-poisoned rats in comparison with the group receiving tin chlorid4 only. However, 110-day treatment with Ukrain in doses of 7.0 and 14.0 mg/kg i.p. decreased the activity of ST (only in a dose of 15.0 mg.kg i.p.) in the serum of tin-poisoned rats.


    1520/2523

    Tytuł oryginału: Qualitative properties of Melissa officinalis L. during ontogenetic development.
    Tytuł polski: Jakościowe właściwości Melissa oficinalis L. podczas rozwoju ontogenetycznego.
    Autorzy: Vaverkova S., Holla M., Tekel J., Haban M., Vozar I.
    Źródło: Herba Pol. 2002: 48 (4) s.289-294, il., tab., bibliogr. 11 poz., streszcz. - 3 Międzynarodowe Sympozjum Chromatograficzne nt. produktów pochodzenia naturalnego Kazimierz Dolny 12-15.06. 2002
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Badano jakościowe właściwości: Melissa officinalis L. pochodzącej z 3 stanowisk Republiki Słowackiej w 5 okresach rozwoju. Wyniki badań są średnimi z otrzymanych wartości. Stwierdzono, że zawartość olejku eterycznego w liściach badanej rośliny była wyższa we wcześniejszych okresach rozwoju ontogenetycznego. Skład olejku występującego w liściach i łodygach także zależny był od fazy rozwoju ontogenetycznego. Zaobserwowano istnienie ścisłej zależności pomiędzy zawartością cytronellalu, neralu i geranialu.

    Streszczenie angielskie: Qualitative properties of Melissa officinalis L. have been studied during five vegetation periods at three localities in Slovak Republic. The results are averages of the factors under investigation. The oil content in individual leaf insertions ranged in the way that the highest amount of the oil was contained in ontogenetically youngest ones. The composition of the oil in stalks and leaves depended also on the ontogenetic phase of plant development, whereas exists a close relationship among the contents of citronellal, neral and geranial.


    1521/2523

    Tytuł oryginału: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine. Łajs, 25-28 September 2002
    Opracowanie edytorskie: Foryś Urszula (ed.), Ziółko Mariusz (ed.).
    Uniwersytet Wydział Matematyki, Informacji i Mechaniki, Instytut Matematyki Stosowanej i Mechaniki w Warszawie, Uniwersytet Górniczo-Hutniczy Zakład Elektroniki
    Źródło: - Warszawa, UW 2002, 154 s. : il., tab., bibliogr. [przy rozdz.], 24 cm. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1522/2523

    Tytuł oryginału: False nearest neighbours method in analysis of EEG time series
    Autorzy: Boguś Piotr, Jakitowicz Janusz
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.9-14, il., bibliogr. 11 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1523/2523

    Tytuł oryginału: Petiole measurements and fractal dimensions of outlines as useable features in automatic identification of plants
    Autorzy: Borkowski Wojciech
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.15-23, il., tab., bibliogr. 22 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • badanie porównawcze
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1524/2523

    Tytuł oryginału: An application of Kohonen neural network for T wave alternans detection in the ECG signal
    Autorzy: Chmielowiec Aleksander, Skorupski Andrzej
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.25-30, il., bibliogr. 4 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1525/2523

    Tytuł oryginału: Mathematical model of photosynthesis process in leaf
    Autorzy: Dawidowicz Antoni Leon, Zalasiński Jerzy Leszek
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.31-36, il., bibliogr. 16 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1526/2523

    Tytuł oryginału: Delay logistic equation with diffusion
    Autorzy: Foryś Urszula, Marciniak-Czochra Anna
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.37-42, il., bibliogr. 16 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1527/2523

    Tytuł oryginału: Some remarks on coral reefs, mathematical modelling and organic architecture of the future
    Autorzy: Nowak Jakub, Foryś Urszula, Mokwa-Borkowska Anna
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.43-48, il., bibliogr. 8 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1528/2523

    Tytuł oryginału: Transmittance coefficients for high flux hemodialyzers
    Autorzy: Gałach Magda, Ciechanowska Anna, Sabalińska Stanisława, Waniewski Jacek, Wójcicki Jan M., Weryński Andrzej
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.49-56, il., tab., bibliogr. 4 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1529/2523

    Tytuł oryginału: Application of statistical methods in health psychology
    Autorzy: Gałuszka Anita
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.57-62, tab., bibliogr. 16 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • kardiologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1530/2523

    Tytuł oryginału: Simulation of the initiation of pulse wave in the ascending aorta with the connected use of FPM and FEM
    Autorzy: Kalita Piotr, Paszyński Maciej, Pelc Andrzej
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.63-68, il., bibliogr. 17 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1531/2523

    Tytuł oryginału: Speech signal segmentation
    Autorzy: Kępiński Michał, Ziółko Mariusz
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.69-74, il., bibliogr. 8 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1532/2523

    Tytuł oryginału: On a mathematical model of humoral immune response against cancer
    Autorzy: Kolev Mikhail
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.75-81, il., bibliogr. 7 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1533/2523

    Tytuł oryginału: Sampling with replacement dependent upon size
    Autorzy: Kopocińska Ilona, Kopociński Bolesław
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.83-88, tab., bibliogr. 11 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1534/2523

    Tytuł oryginału: Description of human growth using mathematical models
    Autorzy: Kosińska Magdalena, Sitek Mirosława
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.89-94, il., tab., bibliogr. 18 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta


    1535/2523

    Tytuł oryginału: Describing competitive systems at the level of interacting individuals
    Autorzy: Lachowicz Mirosław
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.95-100, bibliogr. 12 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1536/2523

    Tytuł oryginału: Modeling of non-linear fluid by the fluid particle model with the application to blood flow simulations
    Autorzy: Paszyński Maciej, Schaefer Robert
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.101-107, il., bibliogr. 13 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1537/2523

    Tytuł oryginału: Numerical aspects of optimal input design for pharmacokinetic compartmental models
    Autorzy: Pietrenko-Dąbrowska Anna, Kalicka Renata
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.109-114, il., bibliogr. 5 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1538/2523

    Tytuł oryginału: Variational formulation of three dimensional blood flow in arteries, with non-linear Casson constitutive equation
    Autorzy: Schaefer Robert, Paszyński Maciej
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.115-120, il., bibliogr. 16 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1539/2523

    Tytuł oryginału: Comparision of phylogeny algorithms under assumption of different transition and transversion rates
    Autorzy: Starosolskii Zbigniew
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.121-126, il., tab., bibliogr. 6 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1540/2523

    Tytuł oryginału: Frequency analysis of open air temperature
    Autorzy: Sypka Przemysław, Ziółko Mariusz
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.127-132, il., bibliogr. 3 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1541/2523

    Tytuł oryginału: Positive feedback in a broad class of models of drug resistance
    Autorzy: Śmieja Jarosław, Świerniak Andrzej, Polański Adam, Kimmel Marek
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.133-141, bibliogr. 17 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1542/2523

    Tytuł oryginału: Modelling of lineshapes in electron spin resonance spectra of spin labelled cell membranes
    Autorzy: Świrydowicz Sławomir, Penkowski Michał
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.143-147, bibliogr. 5 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1543/2523

    Tytuł oryginału: A simple mathematical model for tumour-immune system interactions
    Autorzy: Waniewski Jacek, Zhivkov Petar
    Źródło: W: Proceedings of the Eight National Conference on Application of Mathematics in Biology and Medicine - Warszawa, 2002 s.149-154, il., bibliogr. 5 poz. - 8 Krajowa Konferencja pt. Zastosowanie matematyki w biologii i medycynie Łajs 25-28.09. 2002
    Sygnatura GBL: 735,628

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1544/2523

    Tytuł oryginału: Candida albicans Berthout, 1923: hydrolases activity and own method of digestive tract strains biotyping.
    Autorzy: Kurnatowski Marek, Wąsowska-Królikowska Krystyna, Kurnatowska Alicja
    Źródło: Wiad. Parazytol. 2002: 48 (4) s.441-445, tab., bibliogr. [5] poz.
    Sygnatura GBL: 303,658

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: 112 strains of Candida albicans were isolated from oral cavity and ontocenoses of the upper digestive tract (endoscopy) of children (age: 5-17) with gastrointestinal disorders. Axenic strains were differentiated with API 20C AUX and API ZYM tests (bioM‚rieux). Then enzymograms and biotypes were determined for all the strains based on the activity of 19 hydrolases. The highest activity was noted for: e2 - phosphatase alcaline, e6 - leucine arylamidase, e11 - phosphatase acid, e5 - lipase (c14); e7 - valine arylamidase, e12 - naphtol-AS-BI-phosphohydrolase, e16 - ŕ-glucosidase and e18 - N-acetyl-á-glucosamidase, and the latter four were used for biotyping procedures. Our own system was based on the mathematical binominal distribution formula (1 : 4 : 6 : 4 : 1): all "+"; one "-", three "+"; two "-", two "+"; three "-", one "+"; all "-". We have found the following biotypes A (16.1 ń 3.5 p.c.), B1 (2.7 ń 2.53 p.c.), B3 (8.0 ń 2.5 p.c.), B4 (22.3 ń 3.9 p.c.), C2 (1.8 ń 1.3 p.c.), C3 (7.1 ń 2.4 p.c.), C6 (30.4 ń 4.3 p.c.), D3 (11.6 ń 3.0 p.c.).


    1545/2523

    Tytuł oryginału: The tobacco atlas
    Autorzy: Mackay Judith, Eriksen Michael
    Źródło: - Geneva, World Health Organization 2002, 128 s. : il., tab., 25 cm.
    Sygnatura GBL: 554,750

    Typ dokumentu:
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1546/2523

    Tytuł oryginału: The World health report 2002 : reducing risks, promoting healthy life
    Źródło: - Genewa, World Health Organization 2002, XX, 248 s. : il., tab., bibliogr. [przy rozdz.], 26 cm.
    Sygnatura GBL: 805,638

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1547/2523

    Tytuł oryginału: Health, disease and illness. P. 1: Do we understand our patients?
    Autorzy: Melker Ruut de
    Źródło: Probl. Med. Rodz. 2002: 4 (2) s.6-11, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,528

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Health is a dynamic state related to (sub)cultural factors and to good coping behaviour when dealing with day-to-day problems of life, including any symptoms. The doctor's perspective relates to a more or less objective diagnosis, the disease. The patient's perspective relates to feelings, meanings of perceived symptoms, and the illness. Feeling well doesn't mean that a person has no symptoms. On the contrary, having one or more symptoms is normal: about ninety per cent of people experience at least one symptom during any two-week period. However, only about ten per cent of such symptoms are presented to a professional. Even family doctors see only a selected part of the total morbidity spectrum in a population. The main part of total perceived symptoms is bidden, like the submerged portion of an iceberg. It is a mistake to think that this bidden morbidity consists just of minor symptoms. Even very serious symptoms are sometimes not presented to a doctor. We tend to underestimate the importance of self-limiting diseases and self-care. Studies show that there are also a lot of hidden pathogenic microbial agents which are a threat for certain risk groups. There is also a submerged iceberg of chronic diseases. People's views of their symptoms differ from the medical view. The first question in a consultation should not be "What is the diagnosis?", but "Why is this patient asking me for help today?" If the family doctor doesn't clarify why the patient has come to see him, it will lead to a poor patient-doctor relationship, ineffective care, dissatisfaction, and ...


    1548/2523

    Tytuł oryginału: Diagnostic assessment of postthrombotic syndrome.
    Tytuł polski: Diagnostyka zespołu pozakrzepowego.
    Autorzy: Poredos Pavel
    Źródło: Prz. Flebol. 2002: 10 (2) s.45-48, bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 313,489

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Zespół zakrzepowy (PTS) przedstawia różnorodny obraz kliniczny będący następstwem zakrzepicy żył głębokich. Głównym patomechanizmem zespołu pozakrzepowego jest niewydolność zastawkowa rekanalizowanego segmentu żylnego i bocznic, powodująca nadciśnienie żylne. Podstawą diagnozy jest badanie kliniczne, jednakże dla rozpoznania niewydolności zastawkowej i refluksu niezbędne są badania dodatkowe. Istnieje kilka nieinwazyjnych metod oceny niewydolności zastawkowej takich jak: fotopletyzmografia, Ta: Doppler o fali ciągłej oraz duplex-scan. Pletyzmografia żylna jest metodą niezbyt kosztowną oraz łatwą do nauczenia. Badanie wskazuje na rozległość niewydolnego segmentu zastawkowego, jednak nie wnosi wiele więcej precyzyjnych informacji, niż dokładne badanie zmian skórnych. Ostatnio badanie duplex-scan łączące prezentację ultrasonograficzną B obrazu żył z dopplerowskim pomiarem przepływu znalazło zastosowanie do oceny żył głębokich i powierzchownych u chorych z przewlekłą niewydolnością żylną. Duplex-scan jest w stanie wykryć, zlokalizować i ocenić stopień refluksu krwi w układzie żylnym. Aparatura do wykonywania tego badania jest jednak bardziej kosztowna oraz wymaga większego doświadczenia od badającego w porównaniu z pletyzmografią. Doppler o fali ciągłej jest prostym badaniem do rozpoznania refluksu żylnego, jednak jego powtarzalność i swoistość są niskie - zwłaszcza dla niedoświadczonej osoby. Zmiany wolumetryczne objętości kończyny są zależne od refluksu krwi. Technika ta jest skomplikowana i rzadko używana rutynowo w praktyce klinicznej. Również flebografia, która jest...


    1549/2523

    Tytuł oryginału: Immunological characterization of the Campylobacter jejuni 72Dz/92 cjaD gene product and its fusion with B subunit of E. coli LT toxin.
    Autorzy: Wyszyńska Agnieszka, Pawelec Dariusz P., Jagusztyn-Krynicka Elżbieta K.
    Źródło: Acta Microbiol. Pol. 2002: 51 (4) s.313-326, il., tab., bibliogr. s. 324-326
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Campylobacter jejuni 72Dz/92 cjaD gene, orthologue of C. jejuni NCTC 11168 cj0113, C. jejuni M275 ompl18 and C. jejuni ATCC 29428 omp18, has been cloned, sequenced and analysed from the viewpoint of its immunological attributes. Neither the 5' nor 3' fragment of the cjaD encodes protein capable of reacting with anti-Campylobacter antibodies. Several fusions of the cjaD with eltB, which encodes B subunit of the E. coli LT toxin, have been constructed. The hybrid proteins, which differ in respect to their cellular localization, retain the ability to react with GM1 and are recognized by the antibodies specific for both moieties of the proteins. The fusion protein equipped with signal sequence, reveals a stronger affinity to GM1 than ints equivalent which is unable to cross the inner membrane. Two recombinant plasmids (pUWM405 expressing both LTB and CjaD proteins and pUWM299 containing cjaD gene fused into 3' end of Escherichia coli eltB gene lacking signal sequence) were introduced into avirulent Salmonella enterica servoar Typhimurium strain where they are stably maintained.


    1550/2523

    Tytuł oryginału: Detection of Escherichia coli O157:H7 in raw meat by immunomagnetic separation and multiplex PCR.
    Autorzy: Łękowska-Kochaniak Aneta, Czajkowska Danuta, Popowski Janusz
    Źródło: Acta Microbiol. Pol. 2002: 51 (4) s.327-337, il., tab., bibliogr. s. 336-337
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: The aim of this research was to elaborate fast and sensitive method of detection of E. coli O157:H7 in food samples. Raw ground meat obtained from retail was artificially inoculated with low numbers of E. coli O157:H7. 18 h enrichment culture allowed pathogenic bacteria to multiply to the levels detectable in multiplex PCR. Immunomagnetic separation with magnetic beads coated with an antibody against E. coli O157:H7 were used to concentrate target bacteria and to separate PCR inhibitors. A portion of the bacterial suspension was used in a multiplex PCR to amplify eae (attaching and effacing) gene, stx (shiga toxin) genes and 90 kbp plasmid. The sensitivity of E. coli O157:H7 detection method was shown to be 1 cfu per 25 g of food sample. The total analysis can be completed within 24 h, whilst traditional methods involves enrichment, direct plating and confirmation tests with entire time at least 3 days.


    1551/2523

    Tytuł oryginału: Patients with unstable angina pectoris present increased humoral response against Helicobacter pylori in compariosn with patients with aggravated dyspepsia.
    Autorzy: Rechciński Tomasz, Kasprzak Jarosław D., Chmiela Magdalena, Krzemińska-Pakuła Maria, Rudnicka Wiesława
    Źródło: Acta Microbiol. Pol. 2002: 51 (4) s.339-344, tab., bibliogr. s. 343-344
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • gastroenterologia
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: A role of autoimmune process and its link with bacterial infections in initiation or aggravation of atherosclerosis symptoms has been suggested. Antigenic mimicry and cross-reactivity of circulating antibodies have been indicated as some major factors in this process. In this study, the prevalence and titers of IgG and IgA antibodies reacting with glycine extract of H. pylori surface antigens were determined immunoenzymatically (ELISA) in the group of patients with unstable ischaemic heart disease and in patients with aggravated dyspepsia. Our results reveal that elevated titers of IgG anti-H. pylori are more typical for cardiac patients and lower prevalence of IgA anti-H. pylori - for those with aggravated dyspepsia. This supports the hypothesis that intensed humoral response in immunoglobulins class G against some bacterial antigens may play a role in the aggravation of symptoms of coronary atherosclerosis.


    1552/2523

    Tytuł oryginału: Intraperitoneal fluid accumulation induced by Clostridium perfringens alpha-toxin (Phospholipase C).
    Autorzy: Maegawa Tsuneo, Wang Xingmin, Karasawa Tadahiro, Zuka Masahiko, Kita Hiroyuki, Nakamura Shinichi
    Źródło: Acta Microbiol. Pol. 2002: 51 (4) s.387-389, tab., bibliogr. [10] poz.
    Sygnatura GBL: 302,697

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: We report that the intraperitoneal injection of Clostridium perfringens alpha-toxin into mice induces ascites. This phenomenon was monitored by measuring fluid volume and analyzing hematologic data. The mouse toxicity test provides a simple and useful model for examining C. perfringens alpha-toxin-induced vascular permeability.


    1553/2523

    Tytuł oryginału: Rare types of acute leukaemia - analysis of immunophenotype of leukaemia cells.
    Autorzy: Kacińska Ewa, Balwierz Walentyna, Klekawka Tomasz, Hawrylecka Dorota, Skotnicki Aleksander, Pituch-Noworolska Anna
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.1-13, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The immunophenotype of leukaemia cells of 12 patients with rare types of acute leukaemia were shown. The immunophenotype assay was based on direct staining of leukamia cells with monoclonal antibodies conjugated with phycoerythrin or fluorescein for surface expression of determinants and staining fixed cells for cytoplasm expression of determinants. The analysis described different types of atypical immunophenotypes. The rare types of acute leukaemia included: mixed lineage leukaemia (AMLL), bi-phenotypic and bi-lineage leukaemia (i.e. common ALL/AML), co-expression of determinants from the other cell line (common ALL+My) and a case of clinical co-existence of non-Hodgkin's lymphoma (NHL) and acute myeloblastic leukaemia (AML). The clinical course and results of therapy cases were shortly presented with a discussion.


    1554/2523

    Tytuł oryginału: FcçRIIa polymorphism in a Polish population.
    Autorzy: Pawlik Andrzej, Florczak Marcin, Brzeżniak Ryszard, Dutkiewicz Grażyna, Mizerski Arnold, Gawrońska-Szklarz Barbara
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.14-16, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We have investigated the FcçRIIa polymorphism in a Polish population. The frequency of FcçRIIa alleles was similar to those obtained in other Caucasian populations. There was no differences in this polymorphism between male and female and depending from age studied subjects. The determination of FcçRIIa polymorphism may have implications for future studies designed to elucidate the relationship between FcçRIIa and diseases susceptibility.


    1555/2523

    Tytuł oryginału: Intracellular expression of TNF-ŕ and IL-8 of peripheral blood monocytes and antioxidant defence in nephrotic syndrome.
    Autorzy: Zachwieja Jacek, Niemir Zofia, Bobkowski Waldemar, Dobrowolska-Zachwieja Agnieszka, Zaniew Marcin, Siwińska Aldona, Lewandowska-Stachowiak Maria, Maciejewski Janusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.17-22, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Background. Minimal change nephrotic syndrome is accompanied by and probably related to an abnormal T-lymphocyte and monocyte function. Several immunological abnormalities are in favor of this hypothesis, but until now the precise nature and cause of the disease is not established. Methods. In the present study we measured the expression of TNF-ŕ and IL-8 in peripheral blood monocytes. In addition total antioxidant status (TAS) as well as the antioxidant enzymes activity were measured respectively, in the serum and erythrocytes. 39 children with NS were studied. Of these 20 with the first episode of NS formed group I, and 19 children in remission ( 6 month) of NS formed group II. The age range was 4-17 years with a mean of 8.4. Twenty-life healthy children matched for age constituted the control group. The intracellular expression of cytokines was detected after incubation with Brefeldin A (BFA). Results. TAS was significantly reduced in group I compared to the controls (0.74 ń 0.16 mmol/l vs. 1.14 ń 0.49 mmol/l; p=0.002). Glutathione peroxidase activity was lower in group I compared to the controls (24.56 ń 4.06 U/g Hb vs. 31.25 ń 5.67 U/g Hb, p=0.013). Glutathione reductase activity was lower in group I than in the controls (8.30 ń 1.97 U/g Hb vs. 9.96 ń 3.08 U/g Hb, p=0.048) and was also lower in group II than in the controls (6.98 ń 2.89 U/g Hb vs. 9.96 ń 3.08 U/g Hb, p=0.016). There was no difference in superoxide dismutase activity between the 3 groups (Group I - 1168.45 ń 234.45 U/g Hb; Group II - 1146.56 ń 287.43 U/g Hb; Control - 1056.23 ń 216.32 U/g Hb)...


    1556/2523

    Tytuł oryginału: Serum levels of interleukin-12, interleukin-15 and interleukin-18 and their association with disease activity in patients with systemic lupus erythematosus.
    Autorzy: Robak Ewa
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.23-29, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Systemic lupus erythematosus (SLE) is a highly heterogenous disorder in which multiple immunologic abnormalities have been described. In this study we investigate the serum concentration of interleukin (IL)-12, IL-15 and IL-18 using an enzyme-linked immunosorbent assay (ELISA) in 60 patients with SLE and 20 healthy controls. We also examined a possible association between the serum levels of those proteins and SLE activity as well as particular clinical and laboratory parameters and immunosuppressive treatment. The levels of all three interleukins was higher in SLE patients than in normal persons. There was also a positive correlation between IL-12, IL-15 and IL-18 serum concentration and SLE activity score, but associations were not statistically signicant (p 0.05). We found a significant positive correlation between IL-12 and IL-18 ((= 0.419, p 0.01) and IL-15 and IL-18 ((= 0.500; p 0.001). The level of IL-18 was higher in the SLE patients with serum antinuclear antibodies (median 660.0 pg/ml) than in patients without antinuclear antibodies (median 326.5 pg/ml) (p 0.03) as well as in patients with immunoglobulin deposits at the dermal-epidermal junction (median 746.0 pg/ml and 444.0 pg/ml respectively; p 0.04). The level of IL-12 was also higher in the patients with skin immunoglobulin deposits (328.9 pg/ml) than without this phenomenon (257.0 pg/ml) (p 0.05). The levels of all three cytokines in the patients treated and untreated with immunosuppressive drugs were similar. In conclusion, serum levels of IL-12, IL-15 and IL-18 are higher in SLE patients...


    1557/2523

    Tytuł oryginału: Production of artificial antibodies directed to human sperm surface antigens by filamentous phage display library technique.
    Autorzy: Fiszer Dorota, Rozwadowska Natalia, Grygielska Beata, Domagała Alina, Tomczak Kinga, Kurpisz Maciej
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.30-34, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: We have constructed cDNA library of antibody variable fragments using repertoire of B lymphocytes from healthy individual and from infertile patients with antisperm antibodies in serum. Both pools of cells were deposited in peritoneal cavity of SCID mice and to increase population of specific B cells secreting antisperm antibodies, lymphocytes were immunized in situ with extract of sperm antigens. We used native or deglycosylated sperm extracts for performed immunizations. Obtained in this way primed B cells constituted a source of mRNA for creation of cDNA library. Heavy (ç) and light (kappa and delta) chains were cloned into pComb3HSS vector which formed a basis for phage display library of Fab fragments directed to sperm surface antigens.


    1558/2523

    Tytuł oryginału: Sulfurtransferases activity and sulfane sulfur level in cells of the immune system. Preliminary report.
    Autorzy: Wróbel Maria, Grabowska Agnieszka, Włodek Lidia, Czubak Jerzy, Marcinkiewicz Janusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.35-40, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The activity of rhodanese, cystathionase and 3-mercaptopyruvate sulfurtransferase (MPST), participating in L-cysteine desulfuration, and the level of sulfane sulfur, a product of the process, were determined in murine peritoneal macrophages, bone marrow derived dendritic cells, lymph node lymphocytes, and in macrophage type cell line - J774. Among all the investigated cells, the highest value of MPST activity was detected in the lymphocytes, what - together with the estimated high level of sulfane sulfur-containing compounds - may correlate with the high rate of DNA synthesis and proliferation, characteristic of these cells. Dendritic cells, in turn, showed the highest cystathionase activity and a relatively high MPST and rhodanese activity, but surprisingly, sulfane sulfur was not detected. It would be interesting to explain whether these antigen presenting dendritic cells release sulfane sulfur-containing compounds to stimulate lymphocyte proliferation. In peritoneal macrophages, a relatively high activity of MPST and rhodanese and a high level of sulfane sulfur compounds may provide the pretection against reactive oxygen species produced after their activation. It was also observed that mouse macrophage cell line presented a significantly lower activity of MPST and rhodanese and a lower level of sulfane sulfur in comparison to mouse peritoneal macrophages.


    1559/2523

    Tytuł oryginału: Professor Bernard Zabłocki MD, PhD (1907-2002).
    Autorzy: Madaliński Kazimierz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.41
    Sygnatura GBL: 313,243

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Zabłocki
  • Bernard 1907-2002


    1560/2523

    Tytuł oryginału: Automatic backscatter analysis of regional right ventricular systolic function using colour kinesis in patients with inferior wall acute myocardial infarction with or without right ventricular involvement.
    Tytuł polski: Skurczowa czynność prawej komory u chorych z zawałem ściany dolnej serca. Rola automatycznej detekcji wsierdzia i kolorkinezy.
    Autorzy: Krm Turhan, ™zbay Gltac, Korucu Cengiz, Eker Hseyin, ™ztekin Erkan
    Źródło: Kardiol. Pol. 2002: 57 (11) s.416-421, il., tab., bibliogr. 28 poz., streszcz.
    Sygnatura GBL: 313,397

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wstęp. U chorych z ostrym zawałem serca (AMI) ściany dolnej, czynność prawej komory (RV) w istotny sposób wpływa na funkcję mięśnia sercowego, rokowanie i wydolność wysiłkową. W ostatnich latach do oceny czynności RV wprowadzono wiele metod echokardiograficznych, ale użyteczność nowych metod, takich jak koorikineza (CK) i automatyczna detekcja wsierdzia z automatyczną oceną funkcji "acoustic quantification" (AQ), nie była jeszcze badana. Cel. Sprawdzenie czy AQ i CK mogą służyć do ilościowej oceny globalnej i regionalnej czynności RV u chorych z dolnym AMI. Metodyka. Grupę badaną stanowiło 32 kolejnych chorych z dolnym AMI z zajęciem RV lub bez zawału RV (odpowiednio, n = 17 i n = 15) oraz 15 zdrowych osób kontrolnych odpowiednio dobranych pod względem wieku i płci. Wyniki otrzymane przy pomocy CK i AQ porównano pomiędzy badanymi grupami. W celu dokładnej oceny wsierdzia RV, dokonano dalszej oceny ilościowej CK przy pomocy pomiarów skurczowej ruchomości segmentalnej wsierdzia (SEM). Wyniki. W porównaniu do grupy kontrolnej, chorzy z dolnym AMI mieli obniżoną frakcjonowaną zmianę powierzchni RV, przy czym obniżenie to było istotnie mniejsze u chorych bez zajęcia RV niż u chorych z zajęciem RV (odpowiednio, 30 ń 7 p.c., 36 ń 6 p.c. i 45 ń 6 p.c.; p 0.05 i p 0.01). Również istotne różnice zaobserwowano w średnich wartościach SEM dotyczących ścainy wolnej RV (odpoweidnio, 3,9 ń 1.1 mm, 5.2 ń 1.3 mm i 6.3 ń 1.4 mm; p 0.05 i p 0.01) i przegrody (odpowiednio, 4.9 ń 1.5 mm i 7.2 ń 1.4 mm; p 0.05 i p 0.05). Wnioski. Wyniki nasze wskazują, że nowe techniki echokardiograficzne - AQ i CK, mogą słżyć do oceny zaburzeń kurczliwości prawej komory w przebiegu AMI.


    1561/2523

    Tytuł oryginału: Levels of zinc, copper and selenium in subjects with diagnosed renal neoplasms.
    Tytuł polski: Poziomy cynku, miedzi i selenu u osób z rozpoznanym nowotworem nerki.
    Autorzy: Orłowski Czesław, Matych Józef, Daragó Adam, Jędrzejczak Marian, Sapota Andrzej
    Źródło: Bromatol. Chem. Toksykol. 2002: 35 (4) s.369-375, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 305,377

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem badań był pomiar stężeń wybranych pierwiastków niezbędnych w korze nerek oraz ich wydalania z moczem u osób z rozpoznanym nowotworem nerek. Badania prowadzono w trzech grupach: grupa badana (osoby z rozpoznanym nowotworem nerek, którym operacyjnie usunięto jedną nerkę), grupa kontrolna in vivo (osoby zdrowe), grupa kontrolna post mortem (osoby zmarłe). Poziomy badanych pierwiastków w korze nerek u osób z nowotworem nerek nie odbiegały zasadniczo od poziomów obserwowanych w grupie kontrolnej post mortem, były natomiast znacznie wyższe w korze nerek niż w tkance nowotworowej. Dotyczy to zwłaszcza Zn, który jak wiadomo ulega kumulacji w korze nerek. Istotnym zjawiskiem zaobserwowanym w naszych badaniach jest wzmożone wydalanie badanych pierwiastków oraz białka całkowitego z moczem u osób z nowotworem nerek, w porównaniu z grupą kontrolną. Po usuniecia nerki to wzmożone wydalanie ulegało dalszemu nasileniu. Zjawisko to najwyraźniej widoczne jest dla białka całkowitego oraz miedzi.

    Streszczenie angielskie: The aim of the study was to measure concentrations of selected essential elements (Zn, Cu, Se) in renal cortex and neoplastic tissue as well as their excretion in urine in subjects with diagnosed renal neoplasm. The study was performed in three groups: the investigated group (subjects with diagnosed renal neoplasm, who underwent single nephrectomy), the control group in vivo (healthy subjects), the control group post mortem (dead subjects). The levels of the tested elements in renal cortex in subjects with renal neoplasm did not differ basically from the levels observed in the control group post mortem, however they were significantly higher in renal cortex than in neoplastic tissue. This is particularly related to Zn, which is known to cumulate in renal cortex. In subjects with renal neoplasm increased excretion in urine of nearly all the tested elements was observed before nephrectomy. This phenomenon is most pronounced for whole protein and copper.


    1562/2523

    Tytuł oryginału: Financing a biotech project in Poland. Bacteriophage therapy : case study
    Autorzy: Rychlewski Leszek
    Źródło: W: Bio-Forum III : biotechnology business-science conference - Łódź, 2002 s.7-10 - Konferencja Bio-Forum III nt. biotechnologii Łódź 20-21.05. 2002
    Sygnatura GBL: 735,931

    Hasła klasyfikacyjne GBL:
  • ekonomika

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    1563/2523

    Tytuł oryginału: Amlodypina, nowoczesny antagonista wapnia - metody syntezy.
    Tytuł angielski: Amlodypine, modern calcium antagonist - methods of synthesis.
    Autorzy: Hajmowicz Halina, Jańczewski Dominik, Synoradzki Ludwik
    Źródło: Wiad. Chem. 2002: 56 (5/6) s.469-481, il., tab., bibliogr. 17 poz., sum.
    Sygnatura GBL: 310,575

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The paper is a review of the methods of synthesis of amlodypine (1), 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-pyridino-3,5-dicarboxylate, a modern drug belonging to the calcium antagonists group. The synthesis of amlodypine is a multistep process. A Williamson reaction with the formation of a compound with an ether bond (5) is usually the first step. This reaction is follwed by a Hantzsch reaction with the formation of a correspondingly substituted dihydropyridine ring. Two routes of the realization of this step, which limits the overall process yield, are described. Chlorobenzoic aldehyde (8) and 4-(2-Rn-ethoxy) ethyl acetylacetate (5) are substrates in both routes. Nitrogen in the dihydropyridine ring originates either from methyl aminocrotonate (7) (route I) or from ammonium acetate (11) (by amination of 5) (route II). mlodypine (1) is formed in the third step after deprotecting the amino group or introducing the amino group into the molecule. The formation of amlodypine benzenosulfonate (2) can follow or it can be combined with the third step. There are two valid patents in Poland concerning the preparatation of amlodypine benzenosulfonate (2) of Pfizer and of Lek Polska. A patent application of Adamed is under consideration of the Patent Office.


    1564/2523

    Tytuł oryginału: Nie ma problemu środowiskowych estrogenów.
    Tytuł angielski: Environmental estrogens are not a problem.
    Autorzy: Mastalerz Przemysław
    Źródło: Wiad. Chem. 2002: 56 (5/6) s.483-494, il., tab., bibliogr. 29 poz., sum.
    Sygnatura GBL: 310,575

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • urologia
  • ochrona środowiska

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In ecological literature the term "environmental estrogens" refers to industrial compounds which contaminate the environment and have estrogen-like biological activity. In a strict sense the term should include also estrogens produced by plants (phytoestrogens) but these are scarcely mentioned by environmentalists who all their attention concentrate on man-made chemicals. The first observation of hormonal activity of an industrial chemical dates back to 1950 when Burlington et al. reported that DDT affects the secondary sex characterics of male birds [3]. Similar observations multiplied in later years but the observed effects were alway s weak or very weak and did not attract much interest. The situation changed when environmentalists became aware of the huge propaganda potential of esrogenic activity of pesticides such as DDT and begun using that activity as one of the tools helping their efforts to bring about a ban of man-made pesticidal compounds. In many ecological publications the hormonal activity of industrial compounds was suitably enlarged and horrifying scenarios were developed, some of them predicting even the end of mankind due to cancer and catastrophic reduction of fertility [4-7]. As usual, the mass media are happily helping to ring the alarm bells. Fortunately there are several reasons to dismiss the environmental estrogens scare. First of all, plants such as rice, wheat, cabbage, potatoes and many other contain substantial amounts of compounds with estrogenic activity but are eaten daily without harm. And there are no scientific ground to believe that industirla estrogens are more harmful than phytohormones...


    1565/2523

    Tytuł oryginału: The endovascular treatment of popliteal aneurysms with the Hemobahn system.
    Tytuł polski: Endowaskularne leczenie tętniaków tętnicy podkolanowej za pomocą stentu pokrywanego Hemobahn.
    Autorzy: Flessenk„mper Ingo, Marcus Mario, Podlesny Bogdan
    Źródło: Chir. Pol. 2002: 4 (3) s.113-116, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,505

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Due to multiple problems associated with the conventional open surgical therapy for popliteal aneurysms an interventional approach was sought. Ten patietns were provided with covered stentgrafts (Hemobahn). Eight of these imlantations proved successful in a follow-up control after an average period of 16 months. We observed 2 single occlusions. The reasons for these, as well as the advantages and disadvantages of this method, will be evaluated in the discussion.


    1566/2523

    Tytuł oryginału: Estrogen receptor ŕ and á expression in theca and granulosa cells from women with polycystic ovary syndrome.
    Autorzy: Jakimiuk Artur J., Weitsman Stacy R., Yen Hui-Wen, Bogusiewicz Michał, Magoffin Denis A.
    Źródło: J. Clin. Endocrinol. Metab. 2002: 87 (12) s.5532-5538, il., bibliogr. 40 poz.
    Sygnatura GBL: 310,620

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: A defining characteristic of dominant follicles is high estradiol concentrations. Abnormal expression of estrogen receptors (ERs) could contribute to poor follicular develoment and ovulatory failure in polycystic ovary syndrome (PCOS). The aim of this study was to determine whether there are differences in ERŕ and ERá expression in granulosa cells (GC) and theca cells (TC) from women with PCOS, compared with regulary cycling women. GC and TC were obtained by microdissection from 12 polycystic and 23 normal ovaries. ERŕ and ERá mRNA and protein expression were measured by semiquantitative RT-PCR and Western blot, respectively. In control ovaries, both GC and TC ERŕ mRNAs were higher in small antral (SA) than in dominant follicles. ERŕ mRNA was similar in PCOS and size-matched control follicles. In control follicles, ERŕ protein concentrations were higher in GC than in TC. In GC, the ERŕ concentrations were comparable among SA, dominant, and PCOS follicles. In TC, ERŕ concentrations were lower in dominant follicles but were markedly increased in PCOS. In control ovaries, GC and TC expression of ERá mRNA was higher in SA, compared with dominant follicles. In PCOS, ERá mRNA was intermediate between SA and dominant follicles in both GC amnd TC. In GC, the ERá protein concentrations followed the same pattern as mRNA expression; but in TC ERá, protein in PCOS was equivalent to that in dominant follicles. The results of this study demonstrate that there are significamnt alterations in the expression of ERŕ and ERá in PCOS that may be related to abnormal follicular development.


    1567/2523

    Tytuł oryginału: Multiple pregnancies in ART: our responsibility to inform the patients.
    Autorzy: Shenfield F.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.275-278, bibliogr. 11 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: In this article, we ask whether publication of results increases patients autonomy in ART, and what are the differences between adversing and informing in a field where access in often unjustly restricted. The need for the publication of complications, especially this of multiple pregnancies, and our responsibility to the future child is stressed.


    1568/2523

    Tytuł oryginału: Short-term combined hormone replacement therapy in menopausal subjects - does it have any impact on coagulation and fibrinolysis?
    Autorzy: Stachowiak G., Połać I., Jędrzejczyk S., Pakalski A., Stetkiewicz T., Pertyński T.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.279-286, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Objective: to evaluate alterations in coagulation and fibrynolisis variables during 6 months of HRT applied in postmenopausal women. Methods. Our study group were forty six postmenopausal females with climacteric symptoms, who during 6 months received hormonal treatment consisting of transdermal 17-beta-estradiol (17á-E2, 50 mvg/day) ond oral medroxyprogesterone acetate (MPA, 5 mg/day). Controls were forty two healthly age-matched women who were not hormonally treated. At baseline, then in 3rd and 6th month of our trial in all the females the following coagulation and fibrynolosis parameters were measured in blood serum: prothrombin index, INR, APTT, thrombin time, platelet count, fibrinogen, D-dimer, thrombin-antithrombin III complexes, factor VII, antithrombin III, protein C, protein S, PAI-1, t-PA. Results: After 3 months of HRT we observed in the postmenopausal group a lowered prothrombin index with enhanced INR values as compared to the controls. Then 6 months of HRT therapy revealed in the study group a drop in factor VII activities accompanied with increased activities of protein C.


    1569/2523

    Tytuł oryginału: Transcriptional activity of gene P53 and H2b/H4 histone encoding genes as molecular markers in vulvar carcinoma at various stages of advancement of the neoplastic process.
    Autorzy: Paul M., Mazurek U., Kuśmierz D., Wilczok T., Witek A.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.287-291, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Subjects: P53 overexpression or mutations correlate with poor prognosis and high prolifeartive activity in human tumors. Aim. The aim of the study was to evaluate the usefulness of P53 and histone 2Hb/H4 genes expression level as a marker of vulvar carcinoma. Material and methods: The level of P53, 2Hb and H4 mRNA was estimated using RT-QPCR method in vilvar carcinoma (n = 27) at vartious stages of advancement of the neoplastic process. Results: In our experiments the average H2b and H4 genes expression was significantly higher lymph nodes in comparison of normal lymph nodes. Ca vulvae G2 showed significantly higher P53, H2b and H4 mRNA levels than normalk tissues. Ca vulvae G3 showed higher P53 and H2b mRNA levels and lower H4 mRNA level than normal tissues. Conclusion: The results confirm advantage of estimation of P53, 2Hb and mRNA levels as a marker of vulvar carcinoma. Overexpression of H2b encoding gene appears to be connected with genetic instability.


    1570/2523

    Tytuł oryginału: Integrin pattern in rats endometrium after endometriosis induction.
    Autorzy: Szymanowski K., Florek E., Mikołajczyk M., Skrzypczak J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.293-298, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Purpose: The aim of the study was to describe the expression of ŕ3á1, ŕ4á1 and á1 integrins in rats endometrium and their possible changes after surgically induced endometriosis. Material and methods: An experimental was performed on 28 Wistar rats. Fragment of endometrium was implanted into the mesentery of the contralateral horn of the uterus. At the time of the second laparotomy endometrial foci were found in 21 rats. Endometrial foci were excised and fragment of uterine horn of all animals was taken for immunohistochemical staining for ŕ3á1, ŕ4á1 and á1 integrins. Results: Pirmarily all integrins presented identical integrin pattern - no staining in uterine glandular epithelium and moderate or strong in stromma and blood vessels epithelium. In the material from the second laparotomy we observed expression of ŕ3á1 in glandular epithelium of 17 rats. Among them 16 had endometriosis. The next 2 integrins - ŕ4á1 and á1 chain were detected in endometrial glandular epithelium of 18 rats with endometriosis. Conclusion: All the integrins investigated by us were shown to be a good marker of endomteriosis presence.


    1571/2523

    Tytuł oryginału: Integrin pattern in rats endometrium after endometriosis excision.
    Autorzy: Szymanowski K., Mikołajczyk M., Rączyńska P., Florek E., Skrzypczak J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.299-302, bibliogr. 8 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Search for a reliable endometriosis marker still continues. In this study an analysis was performed of the ŕ3á1, ŕ4á1 integrins and á1 integrin subunit in the endometrial glandular epithelium in 28 rats, before peritoneal endometriosis induction, 3 months after induction and 3 months after endometriosis excision. Peritoneal endometriosis induction caused characteristic changes in integrin pattern in uterine glandular epithelium. Of all investigated integrins no one could be detected in glandular epithelium. After endometriosis induction, which succeeded in 21 animals ŕ3á1, ŕ4á1 subunit could be found in endometrial glandular epithelium of 16,18 and 18 animals, respectively. Three months after endometriosis excision these integrins were still present in endometrial epithelium of 6, 5 and 8 rats of the above groups, respectively. The endometrial sampling did not reveal complete return of the integrin pattern in glandular to the pattern observed before endometriosis induction. The question remains whether ŕ3á1, ŕ4á1 and á1 chain has not a fully satisfactory prognostic value in endometriosis diagnosis or did the inflammatory process associated with tissue healing influence integrin pattern.


    1572/2523

    Tytuł oryginału: Urinary lipids in patients with cervical carcinoma: correlation with 24-hour diuresis.
    Autorzy: Górnicki A., Makarewicz R.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.303-308, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Objective: The determination of urinary cholesterol may be an important diagnostic parameter in neoplasms of the genital system, but the mechanism of its excretion in unclear. The aim of this study was to estimate the dependence between lipiduria and glomerular filtration in women with cervical carcinoma. Material and methods. In urine of 26 patients with cervical carcinoma and of healthly women (10) of an equal age and similar profile of diuresis urinary lipids were determined by thin-layer chromatography. In everey case the correlation between the values of different lipids (total and nonesterified cholesterol - NEC, phospholipids and free fatty acids - FFA) and 24-hours diuresis was established. Results. No statistically significant differences between controls and patients were observed in values of different lipids expressed in mg/24h in 24-hour urine samples. There was shown a significant correlation between values of individual classes of excreted lipids and volume of 24-hour urine samples in the group of patients and lack of this correlation in the control group. Therefore, in order to standardize the obtained results they were re-counted and expressed in micrograms per 1-ml of urine. After this procedure, significant differences between controls and patients in mean values of NEC and phospholipids, as expressed in ćg per 1 ml of 24 hour urine no correlation with volume of urine were revelaed. Conclusion: Since the specificity of the urinary lipid determinations as a test for the detection of carcinomas depends...


    1573/2523

    Tytuł oryginału: Reactivity of the sympathetic nervous system and the development of fibrocystic changes in the breast from practitioner's point of view.
    Autorzy: Sieja K., Stanosz S., Błaszczyk M.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.309-313, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Objective: The hypothesis was put forward about the relationship catecholamines with the development of fibrocystic changes in the breast leading on evoluational basis from fibrous subtype, through cystic to fibrocystic. Material and methods: The study included 113 menstruating women. The control group comprised 32 healthy women (mean age 44.9 ń 4.4). The study group included 81 women (mean age 45.5 ń 3.5 y.) with fibrocystic changes in their breasts. Both groups were divided into two age comparments: from 40 to 44 and from 45 to 51 years. The women with fibrocystic changes in their breasts were divided into three subtypes: fibrous, cystic and fibrocystic. Plasma catecholamines concentrations were determined. Results: In women with fibrocystic changes in breasts in age comparment fromm 40 to 44 years, concentratrion of adreneline (p 0.05) was in blood sera significantly higher than in the control group whereas concentration of dopamine was markedly lower. In the age compartment from 45 to 51 years the concentrations of dopamine (p 0.001) was also significantly lower as compared with the control group. Conclusions: 1. Elevated concentration of adrenaline and noradrenaline and decreased of dopamine in blood serum suggest that these monoamines may participate in the pathogenesis of fibrocystic changes of the breasts. 2. Disturbances in catecholamines concentration in women with fibrocystic changes of the breasts indicate the existence of adrenergic system hyperactivity in these women in comparison with the healthly ones. 3. From practitioner's point of view the...


    1574/2523

    Tytuł oryginału: Successful pregnancy outcome in a patient with glycogen storage disease type 1A - case report.
    Autorzy: Czajkowski K., Grymowicz M., Mrozek J., Wójcicka-Bentyn J., Broś M., Sieńko J., Teliga J., Smolarczyk R.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (2) s.315-317, bibliogr. 5 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: In patients with glycogen storage disease type 1A, deficiency of glucose-6-phosphatase results in comparised serum glucose levels control and numerous, metabolic perturbations. We provide a detailed description of the course of pregnancy in the patient with this disorder. Our data suggest that gestation in patients with glycogen storage disease can be successfully managed with carefully monitored protocol of cornstarch supplemented diet.


    1575/2523

    Tytuł oryginału: Triplet pregnancies in women over 40 years of age : a thesis for the degree of doctor of philosophy : doctor thesis
    Autorzy: Keith Louis
    Opracowanie edytorskie: Bręborowicz Grzegorz (supervis.).; Karol Marcinkowski University of Medical Sciences in Poznań
    Źródło: 2002, [1], 128 k. : il., tab., bibliogr. 109 poz., sum., maszyn.
    Sygnatura GBL: 45/20340

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca doktorska
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.


    1576/2523

    Tytuł oryginału: Brain ischemic stroke in children - case analysis with the focus on risk factors.
    Tytuł polski: Udar niedokrwienny mózgu u dzieci - analiza przypadków ze szczególnym uwzględnieniem czynników ryzyka.
    Autorzy: Kopyta Ilona, Emich-Widera Ewa, [Marszał] Elżbieta
    Źródło: Neurol. Dziec. 2002: 11 (22) s.21-27, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 306,367

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Analiza czynników ryzyka u dzieci po przebytym udarze niedokrwiennym mózgu hospitalizowanych w Klinice Neurologii Wieku Rozwojowego w okresie ubiegłych 15 lat. Materiał i metoda: Badaniem objęto 30 dzieci (12 dziewczynek i 18 chłopców), które przebyły udar niedokrwienny mózgu w wieku 12 miesięcy do 15 lat (średnia wieku 8,1 roku). Rozpoznanie udaru niedokrwiennego mózgu postawiono zgodnie z definicją Światowej Organizacji Zdrowia w oparciu o wnikliwy wywiad, badanie neurologiczne, badania neuroobrazowe (CT i/lub MRI, MRA i/lub angio CT). U wszystkich pacjentów przeprowadzono badanie profilu lipidowego (cholesterol całkowity, LDL, HDL, trójglicerydy), poziom fibrynogenu, zbadano czas kaolinowo-kefalinowy (ang. aPTT), poziom przeciwciała antykardiolipinowych w Masach IgM i IgG, aktywność białek C, S, antytrombiny III oraz oporność na aktywną postać białka C (ang. APCR). Wyniki. W badanej grupie pacjentów po przebytym udarze niedokrwiennym mózgu najczęściej występującym czynnikiem ryzyka chorób naczyń mózgowych była dyslipidemia (70 proc.), natomiast deficyt białka S stwierdzono u 20 proc., a APCR u 10 proc. badanych. U kilkorga dzieci ujawniono hyperfibrynogenemię, obecność przeciwciał antykardiolipinowych oraz deficyt białka C. Ponadto u czworga dzieci udar wystąpił po kardiochirurgicznej korekcji wady wrodzonej serca, natomiast jedna pacjentka przebyła ospę wietrzną bezpośrednio przed udarem. Współistnienie kilku czynników ryzyka stwierdzono u większości badanych ...

    Streszczenie angielskie: Risk factors analysis in ischemic stroke children hospitalized at Department of Children Neurology in the period of the last 15 years. Material and method: The study included thirty children (12 girls and 18 boys) who underwent ischemic stroke at the age range between 12 months and 15 years (mean of 8,1 years). The diagnosis of ischemic stroke was formulated according to the definition of WHO following a through interview, neurological neuroimaging examinations (CT, NMR and/or NMA and/or angioCT, eventually classical angiography). In all cases lipid metabolism (total cholesterol level, LDL, HDL triglicerides), fibrinogen level, aPTT, anticardiolipin antibodies of IgM and IgG class, protein C activity, antithrombin III and the resistance to active form of protein C were assessed. Results: The most commonly observed risk factor in ischemic stroke patients of the group under study was dyslipidemia (66,6 p.c.) while protein S deficiency occured in 20 p.c. and the resitance to the active form of protein C and hyperfibrinogenemia in 10 p.c. In four children the stroke followed surgical correction of congenital heart defects, while one patient underwent varicella immidiately prior to the stroke. A few cases revealed the presence of anticardiolipin antibodies and protein C deficit. Concomitant risk factors were present in most of our young patients while there were only three recurrences. Conclusions: The etiologyn of ischemic strokes in majority of patients at the ...


    1577/2523

    Tytuł oryginału: Design, material and modularity of cementless cups
    Autorzy: Effenberger H.
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.99-100 - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro


    1578/2523

    Tytuł oryginału: Validity of cement total hip joint endoprothesis application in patients with ankylosing spondylarthritis
    Autorzy: Gerasymenko S., Polulyakh M., Pidlisetski G.
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.101-102, bibliogr. 5 poz. - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    1579/2523

    Tytuł oryginału: Anatomically adapted, HA coated SBG stem ten years of successful implantation
    Autorzy: Effenberger H., Graf R., Imhof M.
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.103 - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1580/2523

    Tytuł oryginału: Treatment of osteoporotic fractures of the spine by vertebroplasty
    Autorzy: Leong John C. Y., Cheung Kenneth M. C.
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.192, bibliogr. 2 poz. - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1581/2523

    Tytuł oryginału: Surgical tactics of the treatment of the patients with upper extremities' nerves injuries
    Autorzy: Kozlov A. V., Afanasyev L. M., Yakushin L. M., Molochkov E. V.
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.204 - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • traumatologia i ortopedia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1582/2523

    Tytuł oryginału: Rehabilitation after total-knee-arthroplasty
    Autorzy: Grabowski Michael T. W. von, Palme Eckhard, Grabowski Vilia von
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.266-269, il. - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1583/2523

    Tytuł oryginału: The evaluation of results and late complications of radiotherapy in children treated for orbital rhabdomyosarcoma.
    Tytuł polski: Ocena wyników i późnych powikłań radioterapii u dzieci leczonych z powodu mięsaka prążkowanokomórkowego oczodołu.
    Autorzy: Skowrońska-Gardas Anna, Pędziwiatr Katarzyna, Chojnacka Marzanna
    Źródło: Nowotwory 2002: 52 (5) s.389-393, il., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • okulistyka
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Cel. Ocena wyników i późnych powikłań radioterapii u dzieci leczonych z powodu mięsaka prążkowanokomórkowego oczodołu. Materiał i metody. W latach 1980-2000 w I Zakładzie Radioterapii Centrum Onkologii w Warszawie leczono 34 dzieci z rozpoznaniem mięsaka prążkowanokomórkowego oczodołu, w wieku 1-15 lat (mediana 7). Wszystkie dzieci z wyjątkiem 2 otrzymały wstępną chemitoerapię, u 3 zastosowano okaleczający zabieg chirurgiczny (egzenterację). Sześcioro dzieci napromieniano z powodu nawrotu po chemioterapii. U wszystkich dzieci zastosowano chemioterapię megavoltową, za pomocą promieniowania z Co-60 lub akcelatora liniowego. U połowy pacjentów zastosowano indywidualne osłony soczewki i aparatu łzowego. Pięcioro dzieci, leczonych w latach 1996-2000, napromieniano z zastosowaniem technik konformalnych. W celu uzyskania informacji o późnych powikłaniach rozesłano kwestionariusz, z pytaniami dotyczącymi stanu leczonego oka oraz struktur oczodołu i wyglądu twarzy. Wyniki. Trzydziestu jeden pacjentów (91 proc.) żyje, od 24 do 264 miesięcy (mediana 138), po zakończeniu radioterapii i 28 (82 proc.) bez objawów nawrotu. U sześciorga dzieci, napromienianych z powodu wznowy, przeżycie całkowite i bez nawrotu wynosiło odpowiednio 80 proc. i 60 proc. U 33 proc. pacjentów stwierdzono uszkodzenie aparatu łzowego, u 29 proc. zaćmę, i u 20 proc. wpadnięcie gałki ocznej. Retinopatia wystąpiła u 2 dzieci, jaskra u 2, u 3 znaczna asymetria twarzy. W jednym przypadku wykonano enukleację ...

    Streszczenie angielskie: Aim. To analyse treatment results and late complications of radiotherapy in children treated for orbital rhabdomyosarcoma. Material and methods. Between the years 1980 and 2000 34 children (median age 7 yrs. range: 1-15) with orbital RMS, were treated in the 1st Department of the MCCMCC in Warsaw. All but two of the patients received induction chemotherapy; 3 children were treated after ablative surgery (exentertaion); 6 children were irradiated due to recurrence after chemotherapy. All the children were treated with megavoltage radiotherapy from a Co-60 unit or linear accelerator. We applied individual lens and lacrimal apparatus shielding in 16 patients. Five children, treated between 1996-2000, received conformal radiotherapy, with CT and 3-D treatment planning system. To obtain inforamtion about late side effects, we developed a questionnaire, including questions about the status of the affected eye, appearance of the orbit and facial structures. Results. Thirty one patients (91 p.c.) are still living (between 24 and 264 months - median 138 mos) after completion of radiotherapy and 28 (82 p.c.) with no recurrence. In six patients treated due to recurrent tumour OS and DFS was 80 p.c. and 60 p.c., respectively. Late complications were evaluated in 24 patients. We observed lacrimal duct stenosis in 33 p.c., cataract in 29 p.c., enophtalmos in 20 p.c. of patietns. Retinopathy developed in 2 children, glaucoma in 2 pts, and facial asymmetry in 3 pts. In one case ...


    1584/2523

    Tytuł oryginału: Genetic polymorphism of plasminogen activator inhibitor 1 (PAI-1) 1334G/A in patients with colorectal cancer.
    Tytuł polski: Polimorfizm 1334G/A genu inhibitora aktywatorów plazminogenu typu 1 (PAI-1) u chorych na raka jelita grubego.
    Autorzy: Romanowicz-Makowska Hanna, Smolarz Beata, Kozłowska Elżbieta, Przybyłowska Karolina, Kulig Andrzej
    Źródło: Nowotwory 2002: 52 (5) s.394-398, il., tab., bibliogr. 36 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp. Wysoki poziom inhibitora aktywatorów plazminogenu typu 1 (PAI-1) w raku jelita grubego jest związany ze złymi prognozami dla pacjentów. Gen kodujący PAI-1 jest wysoce polimorficzny i przypuszcza się, że zmienność sekwencji genu może wpływać na poziom biosyntezy PAI-1. Mateirały i metody. W obecnej pracy określono rozkład genotypów i częstości alleli polimorfizmu 1334G/A w guzie, prawidłowej błonie śluzowej jelita oraz krwi u 100 chorych na raka jelita grubego. Polimorfizm 1334G/A był analizowany przy zastosowaniu reakcji PCR, z wkorzystaniem starterów allelospecyficznych. Wyniki. Rozkład genotypów polimorfizmu 1334G/A u pacjentów nie różnił się znacząco (p 0.05) od rozkładu przewidywanego przez prawo Hardy'ego-Weinberga. Nie było znaczących różnic w rozkładzie genotypów pomiędzy krwią, tkanką prawidłową, a guzem. Poza tym nie stwierdzono statystycznie istotnych różnic w częstości alleli pomiędzy chorymi na raka jelita grubego, a grupą kontrolną (p 0,05). Wniosek. Uzyskane wyniki sugerują, że polimorfizm 1334G/A genu PAI-1 może nie być związany z występowaniem raka jelita grubego.

    Streszczenie angielskie: Introduction. High concentrations of plasminogen activator inhibitor 1 (PAI-1) are a poor predictive factor for colorectal cancer patients. The PAI-1 gene is highly polymorphic and it is supposed that its variability could contribute to the level of the PAI-1 biosynthesis. Material and methods. We investigated the distribution of genotypes and frequency of alleles of the 1334G/A polymorphism in samples of cancer tissue, distant mucosa and in the blood of 100 patients with colorectal cancer. 1334G/A polymorphism was determined by PCR amplification using allele-specific primers. Results. The distribution of the genotypes of 1334G/A polymorphism did not differ significantly (p 0.05) from that predicted by the Hardy-Weinberg equilibrium. There were no differences in genotype distribution between blood, normal mucosa samples and cancer tissue. Additionally, we found no significant differences in frequencies alleles between colorectal cancer subjects and controls (p 0.05). Conclusion. Our results suggest that 1334G/A polymorphism of PAI-1 gene does not correlate with the development of colorectal cancer.


    1585/2523

    Tytuł oryginału: Clinical symptoms and prognostic factors in breast cancer - related carcinomatous meningitis.
    Tytuł polski: Analiza objawów klinicznych i czynników prognostycznych w nowotworowym zapaleniu opon mózgowo-rdzeniowych u chorych na raka piersi.
    Autorzy: Jagiełło-Gruszfeld Agnieszka, Rudnicka Halina, Niwińska Anna, Mioduszewska Olga, Pieńkowski Tadeusz
    Źródło: Nowotwory 2002: 52 (5) s.399-402, tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. W ostatnim czasie obserwuje się wyraźny wzrost ilości występowania nowotworowego zajęcia opon mózgowo-rdzeniowych wśród chorych na raka piersi. Rokowanie u pacjentek z tą lokalizacją zmian przerzutowych jest bardzo złe. Materiał i metody. W naszej pracy przeanalizowaliśmy 25 przypadków pacjentek z nowotworowym zajęciem opon mózgowo-rdzeniowych. Średnia wieku wynosiła 45 lat (od 29 do 70). Objawy kliniczne, które występowały w momencie rozpoznania, to: bóle głowy, nudności i wymioty, splątanie, zespół móżdżkowy, niedowłady, bóle w okolicy piersiowo-lędźwiowej. W 100 proc. przypadków potwierdzono rozpoznanie poprzez stwierdzenie obecności komórek nowotworowych w badaniu cytologicznym płynu mózgowo-rdzeniowego. U 72 proc. pacjentek obserwowano także podwyższony poziom białka. Leczenie składało się z dokonałowo podawanego raz w tygodniu metotreksatu - 10 mg i Dx - 4 mg. Wyniki. Kliniczną odpowiedź na leczenie oraz poprawę parametrów laboratoryjnych stwierdziliśmy u około 72 proc. pacjentek. Podsumowanie. Nasze obserwacje wskazują, że najważniejszymi korzystnymi czynnikami rokowniczymi w przerzutach do opon móżgowo-rdzeniowych u chorych z rakiem piersi są: jednoczasowe leczenie systemowe, dobry stan ogólny chorych w momencie rozpoznania, dobra odpowiedź klincizna na leczenie metotreksatem, stwierdzona po 2 cyklach leczenia.

    Streszczenie angielskie: Introduction. Carcinomatous meningitis is an uncommon but serious complication of advanced breast cancer, the incidence of which has been, recently, increasing. Material and methods. We have reveiwed 25 cases of carcinomatous meningitis in breast cancer patietns treated inour clinic. The mean age at the time of diagnosis was 45 years (range: 29-70 years). The clinical symptoms at the time of diagnosis were headache, nausea/vomiting, confusion, cerebellar signs, paresis and pain in the thoraco-lumbal region. Cancer cells in cerebrospinal fluid were detected in all the cases. Cerebrospinal fluid protein level was elevated in 72 p.c. of cases. The treatment consisted of intrathecal injection of 10 mg of methotrexate plus dexamethasone 4 mg, adminsitered weekly. Results. The response defined as clinical and laboratory improvement was achieved in 72 p.c. of patients. Conclusion. Our observations suggest that the important prognostic factors in carcinomatous meningitis are: systemic chemotherapy, Karnofsky status at the time leptomeningeal metastases of diagnsois and the clinical response after the first 2 cycles of inthratecal ifnusion of methotrexate.


    1586/2523

    Tytuł oryginału: 500 kHZ intracavitary hyperthermia in the treatment of patients with cervical and endometrial cancer - preliminary results and treatment description.
    Tytuł polski: Wewnątrzjamowa hipertermia 500 kHz w leczeniu chorych na raka szyjki i trzonu macicy - opis metody i wstępne wyniki.
    Autorzy: Piotrkowicz Norbert, Zieliński Jan, Łyczek Jarosław, Dębicki Piotr
    Źródło: Nowotwory 2002: 52 (5) s.403-406, bibligor. 8 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: Terapeutyczne możliwości zastosowania podwyższonej temperatury w leczeniu nowtoworów znane były od dawna. Trudności techniczne w uzyskaniu adekwatnej temperatury w guzie, z jednoczesną ochroną tkanek zdrowych, są jak dotąd postawowym czynnikiem, limitującym szersze praktyczne zastsowanie metody. Materiał i metody. Do przeprowadzenia zabiegów zastosowano sterowany komputerowo generator i 3 wzmacniacze fal radiowych o częstotliwości 500 kHz, przekazujący chorym tkankom energię za pomocą zmodyfikowanego aplikatora (kolpostatu) Fletcher'a. Pomiar temperatury odbywał się za pomocą zestawu trzech termopar. Praktyczny czas przeprowadzenia zabiegu wynosił 60-90 minut. Przeprowadzono 11 zabiegów u 10 chorych z rozpoznaniem raka szyjki macicy i trzonu macicy. Przed rozpoczęciem hipertermii wszystkie chore na raka szyjki poddane zostały napromienieniu z pól zewnętrznych na obszar miednicy małej do dawki 45-46 Gy. Zabieg hipertermii bezpośrednio poprzedzał śródjamową brachyterapię LDR/MDR (dawka 45 Gy/punkt "A" w dwóch etapach), przeprowadzaną za pomocą tego samego kolpostatu. Po poinformowaniu o charakterze zabiegu nagrzewania każdorazowo uzyskiwano zgodę chorej na jego przeprowadzenie. Wyniki. Poza jednym przypadkiem (awaria aparatu) u wszystkich leczonych udało się uzyskać stabilne w czasie terapeutyczne wartości temperatur, a w kilku przypadkach temperatury dochodzące nawet do 48řC były dobrze tolerowane przez chore. Nie stwierdzono żadnych poważniejszych objawów ubocznych zabiegów; nie zaszła konieczność ich przerwania ze względu na brak tolerancji chorej.

    Streszczenie angielskie: The effectiveness of elevated temperature (hyperthermia) in cancer treatment is a well-known issue. However, due to technical problems with generating hyperthermia within the tumour and, at the same time, sparing the healthy tissues, in practice this modality is not widely used. Method. Local hyperthermia was induced by a computer-controlled generator (500 kHz) with three amplifiers transmitting energy to the lesion via a modified uterine brachytherapy applicator. Temperature was measured with 3 thermocouples. Total treatment time was 60-90 minutes. Material. 10 patients with cervical and endometrial cancer were enrolled into this tudy and 11 procedures were performed. Prior to hyperthermia all patients were treated with external field irradiation to the pelvis to the dose of 45-46 Gy. Intracavitary LDR/HDR brachytherapy (dose of 45 Gy/point "A" in two fractions) with colpostat used for the hyperthermia procedure was than performed. Results. In all cases, except one, caused by equipment failure, biologically stable temperature was observed. No severe side effects of treatment were observed. There was no need to terminate treatment due to high temperature intolerance.


    1587/2523

    Tytuł oryginału: Ganglioneurocytoma (central neurocytoma with diffuse ganglionic differentiation) with neuraxis dissemination. Case report and review of the literature.
    Tytuł polski: Ganglioneurocytoma z rozsiewem w centralnym układzie nerwowym. Opis przypadku i przegląd piśmiennictwa.
    Autorzy: Kępka Lucyna, Miller Douglas C., Fijuth Jacek
    Źródło: Nowotwory 2002: 52 (5) s.407-412, il., tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie polskie: Przedstawiono przypadek 46-letniego mężczyzny, u którego dokonano subtotalnej resekcji guza mózgu, zlokalizowanego w okolicy otworu Monroe prawej komory bocznej. W badaniu histopatologicznym zdiagnozowano guz pochodzenia neuronalnego, złożony z 2 typów komórek nowotworowych - neurocytów i komórek zwojowych. Ostatecznie postawiono rozpoznanie histopatologiczne - ganglioneurocytoma. Na podstawie morfologii guza (brak atypii, pleomorfizmu, martwicy) oraz niskiego potencjału proliferacyjnego, oznaczonego za pomocą przeciwciał MIB1, określono, że chodzi o wysokozróżnicowany, dobrze rokujący nowotwór. Stan ogólny i neruologiczny chorego uległ, w ciągu 3 miesięcy po zabiegu operacyjnym, znacznemu pogorszeniu. W rezonansie magnetycznym mózgu wykazano bardzo dużą progresję miejscową nowotworu, z jednoczesnym rozsiewem wzdłuż komór, charakteryzującym się obecnością satelitarnych guzów w rogu skroniowym i potylicznym komory bocznej prawej i jednoczesnym wzmocnieniem kontrastowym wzdłuż komory III. W badaniu cytologicznym płynu mózgowo-rdzeniowego z punkcji lędźwiowej nie znaleziono komórek nowotworowych. Chory został napromieniony na mózg i C1-C2, do dawki 42 Gy w 15 frakcjach, z podwyższeniem dawki na obszar wznowy miejscowej do 46 Gy. Cztery miesiące po zakończeniu radioterapii stwierdzono stabilizację choroby w badaniu radiologicznym i lekką poprawę stanu neurologicznego. Dokonano przeglądu piśmiennictwa dotyczącego tego rzadkiego nowotworu. Zaznaczono, że według niektórych ...

    Streszczenie angielskie: We reprot the case of a 46-year-old man with ganglioneurocytoma, initally managed by subtotal resection. The location of the tumour was typical for central neurocytoma, but there was a rapid local progression (in 3 months) mimicking malignant tumour with simultaneous dissemination in the brain as evidenced by magnetic resonance imaging (MRI). The histological appearance of this tumour lacked features of malignancy and showed tow neoplastic cells types - a predominance of neurocytes with some ganglion cells scattered singly and in clusters in all parts of the tumours. An immunostain for synaptophysin was typical for neuronal tumours. The proliferative potential of the tumour was low, as indicated by an MIB1 immunostain. The disease was managed at progression with radiotherapy delivered to the whole brain (42 Gy in 15 fractions) and with a boost to the primary site (2 fractions of 2 Gy). Four months after radiotherpay the neurological status of the patient had improved and he no longer required steroid administration. MRI revealed tumour stabilisation. We conclude that neuronal tumours like ganglioneurocytoma or central neurocytoma with diffuse ganglionic differentiation may not be as benign as previously thought and discuss other data reporting malignant behaviour of such tumours. Aggressive tumour behaviour can occur in the absence of the described histopathological signs of poor prognosis, making clinical predictions from the pathological data uncertain. The ...


    1588/2523

    Tytuł oryginału: Molecular genetics of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).
    Autorzy: Kowalska Anna
    Źródło: Folia Neuropathol. 2002: 40 (3) s.111-118, il., tab., bibliogr. 81 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • genetyka
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is characterised by behavioural, cognitive and motor disturbances. Pathological changes in the brain include fronto-temporal atrophy with neuronal loss, grey white matter gliosis and superficial cortical spongiform. In addition, introneuronal tau inclusion with the variable occurrence of glial inclusions are present in FTDP-17 brains. The pattern of inheritance in FTDP-17 is autosomal dominant with an early age of onset (45-65 years). The identification of mutations in the tau gene in FTDP-17 demonstrated that there is a direct link between tau dysfunction and neurodegeneration. To date, 14 missense mutations, a three base pair deletion (delta K280) and seven splice site mutations have been found in over 50 FTDP-17 families from different ethnic groups. All of the known mutations occur in the C-terminal end of tau, with the majority affecting exons 9 - 12, which encode the microtubule-binding repeats. The mutations have multiple effects on the biology and function of tau. These varied pathogenic mechanisms most likely explain the wide range of clinical and neuropathological features observed in different families with FTDP-17.


    1589/2523

    Tytuł oryginału: The heterogeneity of neuropathological changes in amyotrophic lateral sclerosis. A review of own autopsy material.
    Autorzy: Adamek Dariusz, Tomik Barbara, Pichór Anna, Kałuża Józef, Szczudlik Andrzej
    Źródło: Folia Neuropathol. 2002: 40 (3) s.119-124, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: As an approach to the validation of different pathological findings in ALS, we have reviewed the histopathological slides of 24 cases (12 men, 12 women) of autopsy-confirmed ALS which had been treated in our centre (18 definite, 3 probable and 3 possible ALS). The mean age and survival was 57.1 years and 23.5 months respectively. The slides (from motor cortex, basal ganglia, brain stem and spinal cord) were reviewed with special attention paid to the severity of motor cortex and corticospinal tract degeneration, infiltrations of macorphages, atrophy of lower motor neurones, accumulation of lipofuscin, chromatolysis and gliosis. We also searched for the occurrence of axonal spheroids and various kinds of inclusions, like Bunina bodies, large hyaline, Lewy-body-like inclusions and even larger "hyaline balls", and ubiquitinated inclusions. The histological examination revealed considerable differences between particular cases. Different kinds of inclusions were found in 19 out of 24 cases. A shorter duration of the disease was found in the cases with numerous macrophages. The apparent histological degeneration of the motor cortex was found in cases with longer duration of the disease. However, the differences were not significant and no correlation between the occurrence of any type of inclusion or any other pathological finding and the duration of the disease was found. Whether apparent pathomorphological "heterogeneity" reflects some true differences in the pathogenesis of ALS is disputable.


    1590/2523

    Tytuł oryginału: Morphological analysis of active microglia - rod and ramified microglia in human brains affected by some neruological diseases (SSPE Alzheimer's disease and Wilson's disease).
    Autorzy: Wierzba-Bobrowicz Teresa, Gwiazda Elżbieta, Kosno-Kruszewska Elżbieta, Lewandowska Eliza, Lechowicz Waldemar, Bertrand Ewa, Szpak Grażyna M., Schmidt-Sidor Bogna
    Źródło: Folia Neuropathol. 2002: 40 (3) s.125-131, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The activation of microglial cells in pathological conditions is manifested primarily by their proliferation, as well as by the occurrence of a new morphological form - rod microglia. In the present study immunohistochemical identification of rod microglial phenotype against ramified microglia was performed on segments of 17 brains derived from 7 cases of encephalitis of viral aetiology (including 5 SSPE cases), 6 cases of Wilson's disesase and 4 cases of Alzheimer's disease. Segments from frontal, temporal and occipital lobes, cerebellum and brainstem were subjected to histological, hostochemical and immunohistochemical reactions. The presence of activated rod and ramified microglia was observed in sections derived from al structures of the brains under study. Both morphological forms of acitivated microglia reacted to antibodies: HLA II, CD68, HAM56 and lectin RCA-1s. Expression of HLA II molecules was less intensive on the surface of microglial rod cells. A positive reaction to PCNA antibody was mainly observed in rod/elongated/cylinder-shaped nuclei, which is a characteristic feature of rod microglia. In the study material, the localisation of microglial processes seemed to depend rather on the structural topography of the cell in the brain than on the nuclear shape of the activated microglial cell. Our observations revealed a strong similarity between immunohistochemical phenotypes of both morphological forms of microglia with the indication that rod microglia is a first developmental form of activated microglia.


    1591/2523

    Tytuł oryginału: The pattern of irreversible brain changes after cardiac arrest in humans.
    Autorzy: Taraszewska Anna, Zelman Irmina B., Ogonowska Wanda, Chrzanowska Hanna
    Źródło: Folia Neuropathol. 2002: 40 (3) s.133-141, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Irreversible brain damage resulting in sustained post-arrest coma is a most serious complication of CA in resuscitated patients. In this study we present the neuropathological examination performed on 17 brains of patients who had remained unconscious for variable post-resuscitation periods and died after survival time ranging from 1 day to 36 days following cardiac arrest. Two main types of irreversible brain lesions were observed. The first one consisted of primary ischaemic selective disseminated neronal death appearing in the form of acidophilic neurones with consecutive neuronal loss and reactive astroglial activation in the brain regions vulnerable to ischaemia or in more widespread distribution. The second included microinfarcts or confluent areas of pancellular necrosis associated with perivascular and diffuse tissue sponginess and was considered as secondary to post-resuscitation systemic and regional circulatory disturbances. These lesions showed multifocal, perivascular and laminar distribution with apparent predilection to the cortical border zones of arterial supply territories and were associated with disintegration and loss of GFAP-reactiave astrocytes. Continuity between the areas of selective neuronal loss and focal tissue pannecrosis with corresponding patchy disappearance of GFAP- and VIM-positive astrocytes indicates the contribution of astroglia in the progression of postischaemic brain lesions. Both types of chagnes, evaluated in the neocortex and hippocampus, were more intensive and heterogeneous in the patients dying after prolonged coms duration than in those with recovery of consciousness within the first days after resuscitation.


    1592/2523

    Tytuł oryginału: Is the normal content of sulfhydryl groups attributable to sparing from dystrophic pathology in dystrophin-deficient muscles?
    Autorzy: Niebrój-Dobosz Irena, Fidziańska Anna, Glinka Zofia, Hausmanowa-Petrusewicz Irena
    Źródło: Folia Neuropathol. 2002: 40 (3) s.143-150, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • zwierzęta
  • myszy

    Streszczenie angielskie: Deficiency of dystrophin in skeletal muscles is supposed to be responsible for all the symptoms associated with Duchenne dystrophy (DMD) and Becker dystrophy (BMD). The dystrophin-deficient mdx mice, however, are clinically almost asymptomatic. Hence, other factor(s) might be responsible for the muscle pathology in DMD and BDM. As sulfhydryl groups are involved in mainatining the structure of membranes and the protein-phospholipid interactions, total, protein-bound and free sulfhydryl groups (-SH) in DMD, BMD, limb-girdle dystrophy (LGMD) and the mdx mice muscles have been determined. A significant decrease of total and protein-bound - SH groups content and an increased proportion of free - SH groups in DMD and BMD was found. In LGMD the changes of total and protein-bound - SH groups content were less expressed. In the mdx mice muscles te content of - SH groups was generally normal, only a higher than normal proportion of free - SH groups content in old and senile animals, especially in their diaphragm, was present. To test the sercolemmal integrity, albumin/creatine kinase (CK) influx/efflux was determined. In early stages of DMD and BMD the albumin influx was increased. In advanced stages of these diseases albumin influx was not observed. In LGMD albumin penetration was present only in a few fibres. CK efflux in vitro was incrased both in early and advanced DMD cases. IN BMD adn LGMD CK efflux was increased only in early stages of the diseases. In mdx mice an increased influx/efflux of albumin/CK was stated in adult animals. The changes persisted in the mdx mice an increased influx/efflux...


    1593/2523

    Tytuł oryginału: IL-15 is elevated in sera of patients with relapsing-remitting multiple sclerosis.
    Autorzy: Losy Jacek, Niezgoda Adam, Zaremba Jarosław
    Źródło: Folia Neuropathol. 2002: 40 (3) s.151-153, tab., bibliogr. 16 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Interleukin-15 is a novel cytokine produced by monocytes/macrophages and sharing several biological activities with IL-2. IL-15 induces T cell proliferation, enhances natural killer (NK) cell cytotoxicity and also stimulates B cells to proliferate and secrete immunoglobulins. The purpose of our study was to measure IL-15 levels in the serum and CSF of 21 patients with relapsing-remitting form of MS, 9 with active gadolinium enhancing lesions in MRI, 12 without enhancing MRI lesions and to compare the results with the control group. IL-15 levels were measured by ELISA. We found a significant incrase of IL-15 in the sera of patients with MS in comparison with the control group consisting of 8 patients with tension headache. IL-15 serum levels were highest in patients with active, gadolinium enhancing lesions. IL-15 CSF levels were low and there was no difference between studied groups. The results may suggest the contribution of IL-15 in the immunopathogenesis of multiple sclerosis.


    1594/2523

    Tytuł oryginału: Apoptosis in non-astrocytic brain tumours in children.
    Autorzy: Buczyński Jarosław, Jesionek-Kupnicka Dorota, Kordek Radzisław, Zakrzewski Krzysztof, Polis Leszek, Liberski Paweł P.
    Źródło: Folia Neuropathol. 2002: 40 (3) s.155-159, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Apoptosis is a process of great significance in cell biology. It plays a crucial role in both physiological and pathological conditions. An example is a tumour growth that is based on a subtle balance between cell division and cell death. Previously necrosis was considered to be the major type of cell death in tumours. Many recent investigations have focused on apoptosis, a phenomenon of great importance, and it is this type of cell death that is frequently "chosen" by a moribund cell. The objects of our interest were central nervous system (CNS) tumours, in which we estimated the number of apoptotic cells and sought for any correlation between the intensity of apoptosis and other markers of proliferation. Therefore, we studied CD34, the marker of angiogenesis, and Ki67, the marker of cell proliferation. We investigated 19 medulloblastomas and 15 ependymomas, among which 6 were anaplastic. We used in-situ labelling of DNA fragments to detect apoptosis in paraffin-embedded tissues. The mean value of the apoptotic ratio (AR) for all examined brain tumours was 0.012 with a standard deviation (SD) of 0.032, for medulloblastomas 0.021 (SD 0.04), for ependymomas 0.001 (SD 0.002) and for anaplastic ependymomas 0.004 (SD 0.003).


    1595/2523

    Tytuł oryginału: A case of pseudo-aprosencephaly.
    Autorzy: Dąmbska Maria, Taraszewska Anna, Czwalińska Tamara
    Źródło: Folia Neuropathol. 2002: 40 (3) s.161-164, il., bibliogr. 11 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: We present a case of rare, severe brain malformations. In a microcephalic premature newborn only a small structure found in the base of the cranium corresponded to the prosencephalic part of the brain. The basal ganglia were lacking and the cortico-subcortical area changed into empty vesicles with only small fragments of cortical stripe. This picture authorises us to speak on the probably complex pathomechanism of anomalies: genetically caused malformations including underdevelopment of telencephalic nuclei and additional occurrence of extrinsic lesions leading to pseudo-aprosencephaly formation.


    1596/2523

    Tytuł oryginału: The effect of whole-body cryotherapy on lipids parameters in experimental rat model.
    Tytuł polski: Wpływ ogólnoustrojowej krioterapii na parametry lipidowe u szczurów.
    Autorzy: Skrzep-Poloczek Bronisława, Romuk Ewa, Birkner Ewa, Wiśniowska Bernadeta, Beck Brygida, Jagodziński Leszek, Stanek Agata, Teister Maria, Sieroń Aleksander
    Źródło: Balneol. Pol. 2002: 44 (1/4) s.7-13, il., tab., bibliogr. 21 poz., streszcz.
    Sygnatura GBL: 305,284

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: W ostatnich latach obserwujemy ogromny wzrost zainetersowania oddziaływaniem niskich temepratur na organizmy żywe. Temepraturuy kriogeniczne (krańcowo niskie) są coraz częściej stosowane w medycynie i biologii. Szybko rozwijająca się krioterapia wykorzystuje działanie niskich temepartur do stymulowania fizjologicznych reakcji organizmu na zimno. Zastosowanie ogólnoustrojowe temperatur kriogenicznych wywołuje wiele reakcji: przeciwbólową, nerwowo-mięśniową, przeciwobrzękową, odpornościową, hormonalną oraz krążeniową. Ich podstawą są procesy termoregulacji. Brak doniesień na temat zachowania się zwierząt poddanych stymulacyjnemu działaniu krioterapii ogólnoustrojowej skłonił nas do ustalenia optymalnych warunków stosowania właśnie u nich krioterapii. Celem naszej pracy była ocena wpływu niskiej temperatury na parametry lipidowe szczurów. Badania przeprowadzano na 30 szczurach rasy Wistar, samcach o ciężarze ciała 317 ń 24 g. Zwierzęta podzielono na 5 grup po 6 szczurów w każdej. Grupa A została poddana 5-dniowej ekspozycji na temperaturę -60 řC, grupa B - 10-dniowej ekspozycji na temperaturę -60řC, grupa C - 5 dniowej ekspozycji na temp. -90řC, grupa D - 10-dniowej ekspozycji na temp. -90řC, grupa E - kontrola bez ekspozycji. Czas trwania jednego zabiegu wynosił minutę. Po zakończonym cyklu ekspozycji w pobranych próbkach krwi oznaczyliśmy cholesterol całkowity, trójglicerydy oraz cholesterol HDL i LDL (metodą enzymatyczną - zestawami firmy Alpha Diagnostics. Na podstawie uzyskanych wyników mmożna wyciągnąć wniosek, że ...

    Streszczenie angielskie: The main objectives of this study were to quantify in whole body cryotherapy rat model changes in serum lipid profile (plasma triglycerides, total cholesterol, HDL-cholesterol, VLDL + LDL cholesterol). Studies were carried out on 30 adult male Wistar FL rats. Animals were randomized into five groups (6 rats each). Group A - rats exposured for temperature -60řC for 5 days, group B - rats exposured for temperature -60řC for 10 days, group C - rats exposured for temperature -90 řC for 5 days, group D - rats exposured for temperature -90řC for 10 days and group E - control rats - without exposure on cryotherapy. We have observed decrease in body weight of animals exposured for temperature -90řC for 5 and 10 days. Whole body cryotherapy by lowering HDL-C and LDL-C fraction and increasing TG level seems to influence lipoprotein metabolism.


    1597/2523

    Tytuł oryginału: Pathophysiology of ageing.
    Autorzy: Knapowski J[an], Wieczorowska-Tobis K[atarzyna], Witowski J[anusz]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.135-146, il., bibliogr. 44 poz.
    Sygnatura GBL: 302,092

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Ageing is characetrized by a gradual decline in organ functional reserves which reduces the ability to maintain homeostasis under conditions of stress. Introduction of cell culture and molecular biology techniques has provided new experimental tools for the analysis of ageing at the molecular level. During ageing progressive degeneration of cells and loss of regenerative capacity are enhanced and with time the alternations caused by them ultimately lead to death. In this paper teh current knowledge of the mechanisms of ageing is summarized.


    1598/2523

    Tytuł oryginału: Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing.
    Autorzy: Chai J., Tarnawski A. S.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.147-157, il., tab., bibliogr. 68 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including immediate early genes such as c-fos, fosB, junB, egr-1 and -2, neuronal genes such as nurr1 and nur77 and muscle genes such as actins and myosis. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission as well as muscle development and function. SRF can be activated by a variety of agents, including serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-ŕ (TNFŕ), agents that increase intracellular Ca2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes as well as extracellular stimuli such as antioxidant and UV light. SRF itself is regulated by both cellular signal transduction pathways and interaction with otehr transcription factors e.g. Sp1, ATF6 and myogenic regulatory factors. Its biological function is best elucidated for myocardium. Specific cardiac SRF transgenesis demonstrated that overexpression of SRF caused hypertrophic cardiomyopathy in mouse and the mouse died of heart failure within 6 months after birth. Other transgenic data suggested that sufficient SRF was needed for embryogenesis and early development. Since SRF is important regulator of numerous genes involved in cell growth and differentiation, including muscle and neural components, SRF may also play a crucial role in tissue injury and ulcer healing, e.g. healing of gastrointestinal ulcers.


    1599/2523

    Tytuł oryginału: Personal conditions differentiating physiological responses to extremely-low-frequency magnetic fields exposure in the light of R.B. Cattell's theory.
    Autorzy: Pecyna Maria B.
    Źródło: Pol. Psychol. Bull. 2002: 33 (3) s.31-37, il., bibliogr. [32] poz.
    Sygnatura GBL: 305,458

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: From among the students of humanistic faculties two groups (N-46 each) equivalent as regards sex, age, education, place of resistence and at the same time distinquished by the level of fear and anxiety were distinquished by Cattell's 16PF (Sixteen Personality factor Questionnaire). Physiological reactions (EEG with distiquuuished wave rhythms: alpha, beta, theta, SMR and delta, as well as EMG, SC/GSR, HR, BVP, BMP and body termerature) to an effect of magnetic fields generated by magnetostimulator Vifor JPS have been tested three times with non-invasive integrator ProComp +/BioGraph V2.1, i.e.: before exposure (chek-out test), after applying placebo effects (reaction) and after their real exposure. Using the Wrocław taxonomy and faactorial analysis it has been proved that values of autonomous system indicators have been modified multi-directionally by personality features describing level of fear and anxiety. Physiological reactions of system components to low-inductions magnetic field therapeutic effect modified particularly the values of: skin conductivity, breath amplitude and frequency, heart pulse frequency in direction of increased stimulating of parasympathetic system, heading towards organism's homeostasis of those features reacted less to those fields, thus values of their physiological indicators for the same dose of fields were lower. Formulating more detailed conclusions forecasting tighhtly determined mode of dosing magnetic fields by giving all personality features having impact on therapeutic process course in the case...


    1600/2523

    Tytuł oryginału: Polish Psychological Bulletin
    Tytuł angielski: Prevalence of traumatic events and posttraumatic symptomatology among alcohol dependent women.
    Autorzy: Lis-Turlejska Maja, Polak Małgorzata
    Źródło: Pol. Psychol. Bull. 2002: 33 (2) s.13-20, tab., bibliogr. s. 19-20
    Sygnatura GBL: 305,458

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The study examined the prevalence of traumatic events and posttraumatic symptomatology (PTSD, depression and anxiety symptoms) in a sample of 60 alcohol dependet women. The data revealed that 98.3 p.c. of 60 alcohol dependent individuals reported that they has experienced at least one traumatic "it happened to me" event. Highest rates of exposure in their lifetime were reported for "physiological assaault", "sudden unexpected death of some close, "life-theatening illness" and "sexual assault". Prevalence of traumatic exposure before dependence and since dependence was also examined with the data showing a high prevalence of physical and sexual assault. There were two subgroups with a different length of treatment. The data showed that the intensity of both anxiety and depressive symptoms wee significantly lower in the subgroup undergoing longer treatment. That differencxe did not occur for the intensity of PTSD symptoms.


    1601/2523

    Tytuł oryginału: Activation of peroxisome proliferator-activated receptor ç suppresses inducible cyclooxygenase and nitric oxide synthase during oral mucosal ulcer healing.
    Autorzy: Slomiany B. L., Slomiany A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.159-169, il., bibliogr. 44 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Peroxisome proliferator-activated receptor-ç (PPARç) is a ligand-dependent transcription factor, belonging to the steroid hormone receptor family, known to play a pivotal role in the resolution of inflammation. In this study, we investigated the efect of a specific PPAR-ç ligand, ciglitazone, on the course of buccal mucosal ulcer healing by analyzing mucosal activity of inducible nitric oxide synthase (NOS-2) and the expression cyclooxygenases (COX-1 an dCOX-2) responsible for prostaglandin (PG) generation. Methods: Groups of rats with experimentally induced buccal mucosal ulcers were administered twice daily for up to 10 days with ciglitazone at 5, 10, and 15 mg/kg or the vehicle, and their mucosal tissue subjected to assessment of ulcer healing rate and biochemical measurements. Results: The ulcer onset, characterized by up-regulation of NOS-2 and COX-2 protein expression, was reflected in a marked increase in the mucosal PGE2 generation and NOS-2 activity, whereas healing was accompanied by a drop in PGE2 and nOS-2 activity, and a decrease in COX-2 and NOS-2 protein expression. The mucosal expression of COX-1 protein, however, remained unchanged. Administration of ciglitazone led to a significant dose-dependent acceleration in the mucosal reduction of PGE2 generation and NOS-2 activity, and produced a marked decline in COX-2 and NOS-2 protein expression, but the rate of ulcer healing and the expression of COX-1 protein remained unaffected. Conclusions: Our findings thus suggest that the ...


    1602/2523

    Tytuł oryginału: The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication - an electrogastrographic study.
    Autorzy: Budzyński A., Bobrzyński A., Lorens K., Konturek P. C., Thor P., Konturek S[anisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.171-182, il., bibliogr. 34 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Cholecystokinin (CCK) plays an important role in the regulation of postprandial gastric motor activity which was found to be abnormal in duodenal ulcer patients. This study was designed to compare the influence of CCK on gastric myoelectrical function in duodenal ulcer patients and healthy controls. Fifteen patients with activite duodenal ulcer and Helicobacter pylori (H. pylori) infection and 15 healthy controls were included into this study. Electrogastrography w(EGG) was performed before and 4 weeks after the eradication of H. pylori in ulcer patients and in healthy controls. We compared EGG parameters in the fasting and postprandial period and during intravenous infusion of caerulein, and analog of CCK with or without of loxiglumide, a specific CCK-1 receptor antagonist. The amplitude of fasting EGG in duodenal ulcer patients was similar to that in control subjects and was not affected by H. Pylori eradication. In contract, the amplitude of postprandial EGG was markedly increased in duodenal ulcer patients when compared to that in healthy controls and it was significantly reduced following the eradication of H. pylori. The blockade of CCK-1 receptors with loxiglumide in healthy controls or H. pylori eradicated ulcer patients significantly enhanced postprandial EGG amplitude almost to the level observed in the infected duodenal ulcer, patients, but failed to affect this amplitude in ulcer patients. Exogenous caerulein, an analog of CCK, failed to affect EGG amplitude in duodenal ulcer patients with H. pylori ...


    1603/2523

    Tytuł oryginału: The influence of epidermal growth factor on the course of ischemia-reperfusion induced pancreatitis in rats.
    Autorzy: Tomaszewska R., Dembiński A[rtur], Warzecha Z., Ceranowicz P., Konturek S[tanisław] J., Stachura J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.183-198, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Acute pancreatitis is accompanied by the enhanced expression of EGF in the pancreas and the administration of EGF was found to exhibit the beneficial efect on edematous cerulein-induced pancreatitis. Therefore, we decided to determine the influence of EGF on necro-hemorrhagic pancreatitis induced by ischaemia and reperfusion (I/R). Acute pancreatitis ws induced in rats by rectricting the pancreatic blood flow (PBF) in the inferior splenic artery for 30 min using microvascular clips. EGF was administered three times daily (10ć/kg per dose s.c.) starting immediately after the clips removal. Rats were sacrificied on day 1,3,5,10 and 21 following ischemia. PBF was measured using a laser Doppler flowmeter. Morphological signs of pancreatitis, as well as the levels of plasma amylase, lipase, interleukin-1á and interleukin-10 concentration and pancreatic cell proliferation were examined. Results: Ischemia with reperfusion caused necro-hemorrhagic pancreatitis with a histological and biochemical maifestation of pancreatic damage, followed by a spontaneous regeneration. The administration of EGF caused the reduction in the histological signs of pancreatic damage, such as necrosis, edema and leukocyte infiltration, and accelerated the pancreatic repair. Also, EGF treatment significantly attenuated the reduction in pancreatic blood flow and DNA syntehsis. The activity of plasma amylase and lipase, as well as plasma interleukin-1á and interleukin-10 concentrations were decreased in EGF treated animals. Conclusions: ...


    1604/2523

    Tytuł oryginału: Effect of static handgrip on plasma adrenomedullin concentration in patients with heart failure and in healthy subjects.
    Autorzy: Krzemiński K., Kruk B., Wójcik-Ziółkowska E., Kozera J., Cybulski G., Nazar K[rystyna]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.199-210, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie angielskie: Adrenomedullin (ADM) release is enhanced in pheochromocytoma, chronic heart failure (HF), hypertension and renal diseases. This study was designed to test the hypothesis that ADM secretion increases also in response to acute stimuli, such as static effort and to compare plasma ADM response to this stimulus in patients with chronic HF and healthy persons. Eight male HF patients (II/III class NYHA) and eight healthy subjects (C) performed two 3-min bouts of static handgrip at 30 p.c. of maximal voluntary contraction, alternately with each hand without any break between the bouts. At the end of both exercise bouts and in 5 min of the recovery period, plasma ADM and catecholamines were determined. In adition, heart rate, blood pressure, and stroke volume (SV) were measured. The baseline plasma ADM and noradrenaline levels were higher, whilst plasma adrenaline and SV were lower in HF patients than in C group. The 1 st exercise bout caused an increase in plasma ADM from 3.32 ń 0.57 to 4.98 ń 0.59 pmol 1-1 (p 0.01) in C and from 6.88 ń 0.58 to 7.80 ń 0.43 pmolú1-1 (p 0.02) in HF patients. The 2nd exercise bout did not produce further elevation in plasma ADM and during recovery the hormone concentration declined to pre-exercise or lower values. There were no differences between groups in exercise-induced increases in plasma ADM. Plasma ADM correleated with SV (r=-0.419) and with noradrenaline concentrations (r = 0.427) . It is concluded that static exercise causes the short-lasting in plasma ADM conccentration which is similar in healthy subjects and in patients with mild heart failure.


    1605/2523

    Tytuł oryginału: The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+, K+-ATPase activity.
    Autorzy: Bełtowski J[erzy], Marciniak A[ndrzej], Wójcicka G[rażyna], Górny D.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.211-231, il., bibliogr. 51 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Cyclic AMP-protein kinase A (PKA) pathway plays an important role in signal transduction in renal tubular cells, however, its role in transport regulation is not completely estabilished. The aim of this study was to invastigate in vivo the effect of PKA on renal Na+, K+-ATPase activity. The study was performed in male Wistar rats. The animals were anaesthetized with pentobarbital and investigated drugs were infused through the catheter inserted into the abdominal aorta. Na+, K-ATPase activity was assayed in an isolated microsomal fraction of the renal cortex and medulla. Cell-permeable cAMP analogue, dibutyryl-cAMP (db-cAMP), dosedependently stimulated Na+, K+-ATPase in the renal cortex and inhbited in the renal medulla. Maximal stimulation (+38.5 p.c.) and inhibition 9-46.8 p.c.0 were observed at a dose of 10**-6 mol/kg/min. Measurement of Na+, K+-ATPase activity at different Na+concentrations revealed that in the renal cortex db-cAMP increased Vmax of the enzyme without any effect on sodium affinity, whereas in the renalmedulla decrease in Vmax was accompanied by decreased sodium affinity, evidenced by elevated K0.5 for sodium. The effect of db-cAMP was mimicked by the infusion of either adenylate cyclase activator, forskolin, or inhibitor of phosphodiesterase, IBBX. Both stimulatory and inhibitory effects of db-cAMP were prevented by pretreatment with protein kinase A inhibitor, KT 5720 (10**8 mol/kg/min) but not by inhibitor of protein kinase G, KT 5823. The inhibitory effect in the renal medulla was ...


    1606/2523

    Tytuł oryginału: The effect of amphetamine sensitization on mouse immunoreactivity.
    Autorzy: Kubera M., Filip M., Basta-Kaim A., Nowak E., Budziszewska B., Tetich M., Holan V., Korzeniak B., Przegaliński E.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.233-242, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Recent studies indicate a role of the immune system in the behavioral effects of amphetamine in rodents. In the present study we attempted to find a connection between the behavioral changes induced by repeated, intermittent administration of amphetamine and some immunological consequences of sensitization to amphetamine in mice. Male Albino Swiss mice were treated repeatedly (for 5 days) with amphetamine (1 mg/kg, i.p.). On day 9, they received a challenge dose of amphetamine (1 mg/kg). Acute administration of amphetamine increased their locomotor activity by ca. 40 p.c. In animals treated repeatedly with amphetamine, the challenge dose of the psychostimulant induced behavioral sensitization, i.e. the higher locomotor activation as compared with that after its first administration to mice. Immune functions were evaluated by the ability of splenocytes to proliferate and to produce cytokines such as interferon ç(IFN-ç), interleukin (IL)-4 and IL-10. Acute amphetamine administration significantly decreased, by ca. 30 p.c. and 25 p.c., the proliferation of splenocytes in response to an optimal and a suboptimal dose of concanavalin A (Con A), respectively, and increased their ability to produce IL-4. Chronic intermitent treatment with amphetamine significantly decreased, by ca. 65 p.c. and 50 p.c., the proliferative response of T cells to an optimal and a suboptimal dose of Con A, respectively, and diminished by 20 p.c. the metabolic activity of splenocytes. The above data showed that both acute and chronic amphetamine ...


    1607/2523

    Tytuł oryginału: Effect of allopregnanolone on D-[3H]-aspartate release and [3H]-glutamate uptake in the hippocampus of kainate-treated mice.
    Autorzy: Leśkiewicz M., Budziszewska B., Jaworska-Feil L., Lasoń W[adysław]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.243-250, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: In order to determine whether the status epilepticus leads to alterations in th e neurosteroid effect on excitatory amino acid transmission, we studied the influence of allopregnanolone on aspartate release and glutamate uptake in mouse hippocampus at various times after kainate administration. No significant differenses in the K+stimulated D-[3H]-aspartate release from the hippocampi of saline- and kainate-treated mice were observed; however, that parameter tended to fall in tissues collected 1h after kainate administration. Allopregnanolone significantly attenuated the K+-stimulated D-[3H]-aspartate release from the hippocampi of control animals, as well at 24 h and 7 days after kainate injection; in contrast it did not affect amino aaacid release from the hippocamp collected 1h after kainate administration. Kainate administration had noeffect on [3H]-glutamate uptake after 1 and 24 h, but elevated that parameter on day 7. Allopregnanolone (10 and 100 ćM) did not affect [3H]-glutamate uptake in control and kainate-treated mice. In conclusion, the present study indicates a loss of the inhibitory effect of allopregnanolone on the potasium - stimulated D-[3H]-asparate release from mouse hippocampus during the kainateinduced status epilepticus; moreover, it excludes involvement of this neurosteroid in the regulation of hipocampal [3H]-glutamate uptake in both control and kainate-treated mice.


    1608/2523

    Tytuł oryginału: 7- nitroindazole enhances amphetamine-evoked dopamine release in rat striatum. An in vivo microdialysis and voltammetric study.
    Autorzy: Nowak P., Brus R[yszard], Oświęcimska J., Sokoła A., Kostrzewa R. M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.251-263, il., bibliogr. 55 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The intracellular second messenger nitric oxide (NO) is implicated in a variety of physiological functions, including release and uptake of dopamine (DA). In the described study, in vivo microdialysis and differential pulse voltammetric techniques were used to determine the involvement of NO in release of DA and its metabolites (dihydroxyphenylalanine, DOPAC; homovanillic acid, HVA) in neostriatum of freely moving rats. While the NO donor molsidomine (30.0 mg/kg; MOLS) and neuronal NO synthase-(nNOS-) inhibitor 7-nitroindazole (10.0 mg/kg; 7-NI) had no effect on the basal in vivo microdialysate level of DA, 7-NI specifically enhanced D,L-amphetamine- (1.0 mg/kg i.p.; AMPH) evoked release of DA. Basal or AMPH effects on DOPAC and HVA levels were not influenced by MOLS or 7-NI. Findings indicate that nitrergic systems have an important role in mediating effects of AMPH on dopaminergic systems.


    1609/2523

    Tytuł oryginału: Propranolol modifies platelet serotonergic mechanisms in rats.
    Autorzy: Żółtowski R., Pawlak R[obert], Matys T., Pietraszek M., Buczko W[łodzimierz]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.265-274, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Though the mechanisms for the vascular actions of vasodilatory beta-blockers are mosty determined, some of their interactions with monoaminergic systems are not elucidated. Because there are evidences supporting a possible involvement of serotonin (5-HT) in the actions of beta-blockers, we studid the effect of propranolol on peripheral serotonergic mechnaisms in normotensive and Goldblatt two-kidney - one clip (2K1C) hypertensive rats. In both groups of animals propranolol decreased systolic blood pressure, significantly increased whole blood serotonin concentration and at the same time it decreased platelet serotonin level. The uptake of the amine by plateles from hypertensive animals was lower than of normotensive animals and it was decreased by propranolol only in the latter. In both groups propranolol inhibited potentiation of ADP - induced platelet aggregation by serotonin. In conclusion, this study provides evidence that propranolol modifies platelet serotonergic mechanisms in normotensive and renal hypertensive rats.


    1610/2523

    Tytuł oryginału: Effect of adrenergic antagonists and cyclooxygenase inhibitors on the nicotine-induced hypothalamic-pituitary-adrenocortical activity.
    Autorzy: Gądek-Michalska A[nna], Bugajski J., Bugajski A.J., Głód R.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.275-287, il., bibliogr. 24 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Nicotine is a potent stimulus for the hypothalamic-pituitary-adrenal (HPA) axis. Systemic nicotine acts via central mechanisms to stimulate by multiple pathways the release of ACTH from the anterior pituitary corticotrops and corticosterone from the adrenal cortex. Nicotine may stimulate indirectly the hypothalamic paraventricular nucleus, the site of the corticotropin-releasing hormone (CRH) neurons which activates ACTH release. In the present studies an involvement of adrenergic systeman dprostaglandins synthesized by constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2) in the nicotine-induced HPA response in rats was investigated. Nicotine (2.5-5 mg/kg i.p.) significantly increased plasma ACTH and corticosterone levels measured 1 hr after administration. Adrenergic receptor antagonists or COX inhibitors were injected i.p. 15 min prior to nicotine and the rats were decapitated 1 hr after the last injection. Prazosin (0.01-0.1 mg/kg), an ŕ1-adrenergic antagonist, significantly decreased th enicotine-evoked ACTH and corticosterone secretion. Yohimbine (0.1 - 1.0 mg/kg), an ŕ2-adrenergic antagonist, moderately diminished ACTH response, and propranolol (0.1 - 10 mg/kg), a á-adrenergic antagonist, did not significantly after the nicotin-induced hormones secretion. Pretreatment with piroxicam (o.2-2.0 mg/kg), a non-selective COX inhibitor significantly diminished ACTH response. These results indicate that systemic nicotine stimulates the HPA axis indirectly, and both adrenergic system ...


    1611/2523

    Tytuł oryginału: Expression of serum response factor in normal rat gastric mucosa.
    Autorzy: Chai J., Baatar D., Moon W., Tarnawski A[ndrzej]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.289-294, il., bibliogr 10 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Serum response factor (SRF) is a transcription factor that is involved in cell proliferation, muscle and neuron development and maintenance. Its exression in gastric mucosa remains unknown. In this study we demonstrated that SRF is expressed in normal rat gastric tissue as two isoforms and localized mainly to smooth muscle cells of muscularis mucosae and its extensions into the lamina propria, to muscularis propria, and musculature ofthe vascular system. To a lesser extent, SRF is also expressedin the gastric epithelium of the mucosal neck area (proliferative zone0 and in the endothelial cells of microvessels. These data suggest that the main role of SRF in normal gastric tissue is to maintain muscular support and contraction and possibly epithelial regeneration.


    1612/2523

    Tytuł oryginału: Centrally applied vasopressin intensifies hypotension and bradycardia after hemorrhage in SHR rats.
    Autorzy: Dobruch J[akub], Paczwa P., Łoń S., Szczepańska-Sadowska E.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.295-298, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Spontaneuosly hypertensive rats (SHR) have been shown to exhibit several alterations in functions of the intrabrain vasopressinergic system. The present study was designed to find out whether centrally administered vasopressin (AVP) may influence the cardiovascular adaptation to hypotensive hypovolemia in SHR rats. Two series of experiments were performed on conscious 17 SHR rats chronically implanted with lateral cerebral ventricle (LCV) cannulas and with femoral artery catheters. Mean arterial pressure (MAP) and heart rate (HR) were monitored before and after arterial bleeding (1,3 p.c. body weight) performed during LCV infusion of 1) artificial cerebrospinal fluid 5 ćl/hour (aCSF); and 2) arginine vasopressin, 100 ng/hour/5ćl of aCSF (AVP). Central administration of aCSF and AVP had no effect on mAP and HR under resting conditions. Hemorrhage evoked significant hypotension (p 0.001) and bradycardia (p 0.001). During central infusion of AVP hemorrhage resulted in significantly greaterhypotension than during central infusion of aCSF alone (p 0,05). The results provide evidence that centrally applied vasopressin significantly modulates cardivascular adjustments to hypotensive hemorrhage in SHR.


    1613/2523

    Tytuł oryginału: Efficiency of the forebrain commissures: memory for stimuli seen by the other hemisphere.
    Autorzy: Kavcic Voyko, Doty Robert W.
    Źródło: Acta Neurobiol. Exp. 2002: 62 (4) s.235-242, il., tab., bibliogr. s. 242
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: How well will one cerebral hemisphere recognize items viewed initially via the other? Nonverbalizable images or words were presented to one visual field and memory for them tested in the same or the other visual field. The initially viewing hemisphere subsequently had no secure advantage in accuracy, and only for images was there a 30-ms (ca 3 p.c.) penalty in reaction time for viewing with the "other "hemisphere. Interhemispheric mnemonic communication is thus highly reliable. At longer retention intervals (1 - 2 min vs. 4 - 30 s., which accumulating added stimuli), however, recognition of words was asymmetric as to hemisphere, in that initial viewing via the right hemisphere was subsequently (and paradoxically) much better recognized via the left (other) hemisphere than was the converse situation. This suggests that the initial engram with right hemispheric viewing of words ultimately becomes established in the left, and that the right has less accurate access to a previous "left hemispheric view".


    1614/2523

    Tytuł oryginału: Alterations in pattern of rapid eye movement activity during REM sleep in depression.
    Autorzy: Wichniak Adam, Antczak Jakub, Wierzbicka Aleksandra, Jernajczyk Wojciech
    Źródło: Acta Neurobiol. Exp. 2002: 62 (4) s.243-250, il., tab., bibliogr. s. 249-250
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to evaluate REM sleep parameters, especially the temporal characteristics of rapid eye movement activity, in depressed patients, and to compare three different methods for scoring of REM density. The sleep of 15 nonmedicated depressed patients and 13 healthy controls was recorded during two consecutive nights. Sleep recordings were scored by raters blinded to the diagnosis. In comparison to healthy controls depressed patients showed an increased REM density and increased REM activity. Both groups differed also regarding the pattern of REM denisty changes between REM sleep periods (REMPs). Whereas in healthy controls REM density in the first REMP was significantly lower than in the successive REMPs, no such difference was found in depressed patients. On visual inspection we failed to find any significant diffefences in the time course of REM activity within the first REMP in depressed patients. All applied methods for scoring of REM denisty distinguished depressed patients from healthy controls with comparable accuracy.


    1615/2523

    Tytuł oryginału: Effect of sound source position on learning and performance of auditory delayed matching-to-sample task in dogs.
    Autorzy: Kuśmierek Paweł, Kowalska Danuta M.
    Źródło: Acta Neurobiol. Exp. 2002: 62 (4) s.251-262, il., bibliogr. s. 261-262
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • psy
  • płeć męska

    Streszczenie angielskie: Spatial adjacency of stimulus source and response site has been proven important for learning of simple behavioural tasks, including auditory quality and location discrimination. We investigated effect of sound source position (adjacent or not adjacent to manipulanda) on learning and performance of a complex auditory recognition memory task. Spatial adjacency of stimuli and manipulanda imporved learning of a simple auditory directional task, which was an intermediate stage of training. In contrast, no improvement of learning and performance of the recognition task was found.


    1616/2523

    Tytuł oryginału: Temporal order judgement for auditory and visual stimuli.
    Autorzy: Kanabus Magdalena, Szeląg Elżbieta, Rojek Ewa, P”ppel Ernst
    Źródło: Acta Neurobiol. Exp. 2002: 62 (4) s.263-270, il., tab., bibliogr. s. 269-270
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The ability to perceive tempral order for pairs of auditory and visual stimuli was investigated in 12 volunteers. They were asked to make judgements about the order of presented stimuli by pressing two response buttons in a certain order. The performance on auditory and visual tests was studied in relation to the Inter-Stimulus-Interval (ISI), which varied from 5 to 500 ms. In general, the level of performance was similar for the two modalities and the criterion of 75 p.c. of correct responses was rreached at ISI longer than 40 ms, independently of the modality. These findings are consistent with previous research. However, at ISI of 5 ms, a significantly higher level of correctness was observed for the auditory than visual task. Such a tendency was also observed for ISIs of 10, 20 and 40 ms. Better processing in the auditory compared to the visual task at shorter ISIs may result from a different kind of transduction mechanism at the level of receptive cells in each modality. Alternatively, subjects may use two different kinds of response strategies in the auditory modality, only one being comparable to the response strategy in the visual modality.


    1617/2523

    Tytuł oryginału: Testing for non-lineaarity in EEG signal of healthy subjects.
    Autorzy: Stępień Robert A.
    Źródło: Acta Neurobiol. Exp. 2002: 62 (4) s.277-281, il., bibliogr. s. 281
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Spontaneous EEG of 21 healthy human subjects obtained by standard procedure of recording is analysed using non-linear prediction methods to check whether the signals were generated by a non-linear dynamics process or by a linear stochastic process. The test for non-linearity is performed by surrogate data method with non-linear prediction error as the test statistic. The null hypothesis that EEG signal (in rest, with eyes closed) is generated by linear stochastic process can be rejected in 17 cases (5 p.c.) out of the 336 (21 subjects, 16 channels) studied epochs. However, most of these rejections concern 3 subjects. The 88 p.c. of rejections of the null hypothesis concern frontal channels. The null hypothesis is not rejected for epochs recorded with eyes open and during photostimulation.


    1618/2523

    Tytuł oryginału: The European Health Report 2002
    Opracowanie edytorskie: Danzon Marc (przedm.).
    Źródło: - Copenhagen, WHO Regional Office for Europe 2002, V, 156 s., il., tab., bibliogr. [przy rozdz.], 26 cm.
    Seria: WHO Regional Publications, European Series 97
    Sygnatura GBL: 805,641

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca epidemiologiczna
  • informator
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1619/2523

    Tytuł oryginału: Vaccines and biologicals : WHO vaccine-preventable diseases : monitoring system : 2002 global summary
    Źródło: - Geneva, World Health Organization 2002, VII, R-380 s. : il., tab. + płyta CD, 30 cm.
    Sygnatura GBL: 805,653

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne

    Typ dokumentu:
  • informator
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • dokument audiowizualny


    1620/2523

    Tytuł oryginału: Serum thyroid hormones in patients with ankylosing spondylitis.
    Tytuł polski: Stężenie hormonów tarczycy w surowicy krwi u chorych na zesztywniające zapalenie stawów kręgosłupa.
    Autorzy: Kotulska Anna, Kucharz Eugeniusz Józef, Goździk Joanna, Kapołka Danuta, Liwoch-Morżoł Wiesława
    Źródło: Reumatologia 2002: 40 (3) s.131-134, tab., bibliogr. 10 poz., sum.
    Sygnatura GBL: 304,900

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Stężenie hormonów tarczycy i tyreotropiny oznaczono w surowicy krwi u 40 chorych na zesztywniające zapalenie stawów kręgosłupa i u 10 osób zdrowych w podobnym wieku. Stężenie wszystkich hormonów tarczycy, z wyjątkiem całkowitej tyroksyny, było mniejsze u chorych niż w grupie kontrolnej, chociaż stwierdzone wartości stężeń hormonów u chorych mieściły się w zakresie wartości prawidłowych. Nie wykazano różnic stężeń badanych hormonów pomiędzy chorymi kobietami i mężczyznami. Nie stwierdzono korelacji stężenia hormonów z szybkością opadania krwinek czerwonych lub wiekiem badanych osób. Niewielkie zmniejszenie stężenia hormonów tarczycy może być wynikiem odpowiedzi organizmu na przewlekłe zapalenie. Wydaje się, że włączenie tarczycy w proces chorobowy ma mniejsze znaczenie kliniczne u pacjentów z zesztywniającym zapaleniem stawów kręgosłupa niż u chorych na inne układowe choroby narządu ruchu.

    Streszczenie angielskie: Serum thyroid hormones and thyrotropin were determined in 40 patients with anmkylosing spondylitis and 10 age-matched controls. Serum levels of all thyroid hormones but total thyroxine were lower in the patients than in the controls although were within the normal range. There was no difference between male and female patients. The hormone level did not correlate with erythrocyte sedimentation rate or age of the investigated subjects. A slight decrease in thyroid hormone level may be resulted from body reaction to inflammation. Thyroid involvement in patients with ankylosing spondylitis seems to be of lesser clinical value than in the patients with other systemic rheumatic diseases.


    1621/2523

    Tytuł oryginału: TRICOMED S.A. - Polska szkoła biomateriałów.
    Tytuł angielski: TRICOMED S.A. - Polish School of the Biomaterials.
    Autorzy: Raczyński Krzysztof
    Źródło: Polimery Med. 2002: 32 (1/2) s.3-12, il. - Tekst równol. w jęz. ang.
    Sygnatura GBL: 305,609

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca historyczna
  • praca techniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • historia nowożytna
  • historia XX wieku


    1622/2523

    Tytuł oryginału: Poliestrowe protezy naczyniowe.
    Tytuł angielski: Synthetic vascular prostheses.
    Autorzy: Struszczyk Marcin H., Bednarek Paweł, Raczyński Krzysztof
    Źródło: Polimery Med. 2002: 32 (1/2) s.13-22, il., bibliogr. 15 poz. - Tekst równol. w jęz. ang.
    Sygnatura GBL: 305,609

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: Politereftalan etylenowy (PET) i w mniejszym stopniu Teflon (PTFE), stały się głównym syntetycznym materiałem do zastosowań biomedycznych, w przeciwieństwie do nylonu, Ivalonu i Vinyonu-N, które tracą swoją wyjściową wytrzymałość mechaniczną. Właściwości implantów z PET i PTFE pozostają zasadniczo nie zmienione nawet przez długi czas. TRICOMED S.A. wytwarza dziane protezy naczyniowe Dallon wykonane z włókien poliestrowych (PET): Dallon, Dallon H, Tricogel. Protezy naczyniowe Dallon oraz Dallon H są wytwarzane w różnorodnych rozmiarach i kształtach, na bazie przędzy wielowłókienkowej. Protezy te charakteryzują się obustronnie welurowaną powierzchnią. Cecha ta nadaje odpowiednie rozwinięcie powierzchni i wspomaga wgajanie protezy. Dallon H jest protezą naczyniową o unikatowym, wysokim powinowactwie do roztworów, w tym także krwi. Właściwość to 5-krotnie obniża zapotrzebowanie na krew w czasie preclottingu, w powrónnaniu ze standardową protezą naczyniową. TricoGel jest cienkościenną protezą uszczelnioną odpowiednio spreparowaną wieprzową żelatyną. Biokompatybilne uszczelnienie protezy zapewnia całkowitą śródoperacyjną szczelność bez preclottingu oraz optymalny czas wgajania protezy Właściwości hydrofilowe protezy uszczelnionej przejawiają się natychmiastowym nawilżeniem jej powierzchni krwią pacjenta. Krew nie wymywa żelatyny ze ścian protezy, lecz powoduje pęcznienie błony żelatynowej, przczyniając się do uszczelnienia protezy. Po wszczepieniu impregnacja ulega resorpcji przy udziale procesów fizykochemicznych i biologicznych, co wspomaga proces przerastania tkanką protezy i jej wgajanie. Autorzy prezentują dokonania firmy TRICOMED S.A. dotyczące protez naczyniowych wykonanych w włókien poliestrowych.

    Streszczenie angielskie: Polyethyleneterephthalate (PET), and to a lesser extent Teflon have cecome the major synthetic grafting material. Unlike nylon, Ivalon, and Vinyon-N which lose their tensile strength after implantation, PET and Teflon remain essentially unchanged even after long periods. TRICHOMED S.A. produces the family of the knitted vascular implants Dallon made from PET fibres including: Dallon, Dallon H, Tricogel. Both Dallon and Dallon H are manufactured in a form of double (external and internal) velour surface using multifilament yarn and having optimal graft design (a variety of sizes and lengths). The velour surface gives the surface a velvety, plush texture, which improves tissue in - growth. Moreover, Dallon H is a unique vascular prostheses showing the increase in the blood susceptibility that is useful for 4 times less blood demand during preclotting as compared with standard prosthesis. Tricogel graft is made of thin-wall prostheses sealed with the poricne gelatin that provides intraoperative tightness (without preclotting) and the optimal healing process. Hydrophilic behavior of the graft is observed as an instant moistening of the surface with patient's blood and as sweating. The blood stream does not dissolve nor washes away the gelatin but causes the gelatin filn to swell, which makes a better tightness. The work will describe the properties of manmade vascular grafts as well as their applications in the vascular surgery.


    1623/2523

    Tytuł oryginału: Telomerase activity in endometrial cancer - RT-PCR and TRAP studies.
    Autorzy: Romanowicz-Makowska Hanna, Smolarz B., Pertyński T.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.223-230, il., tab., bibliogr 33 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Background: Telomerase, a ribonucleoprotien complex that includes the telomerase RNA component (hTR) and the telomerase catalytic subunit gene (hTERT) product, has been shown to be activated in the majority of cancer tissues. Approach: Results from studies that assayed telomerase activity in endometrial cancer samples are reviewed. Materials and methods: The expression of hTR and hTERT RNAs in tissues of various stages of endometrial cancer was analysed The levels of the RNAs in endometrial cancer and normal tissues by reverse transcription polymerase chain reaction (RT-PCR) were investigated Telomerase activity in cancer and control samples was measured by the TRAP assay (telomeric repeat amplification protocol assay). Conclusion: Several data suggest that the quantitative analysis of hTERT and telomerase activity may have potential roles as prognostic adjuncts for both premenopausal and postmenopausal patients with endometrial cancer


    1624/2523

    Tytuł oryginału: The impact of mood state during pregnancy on duration of pregnancy and infant birthweight: a prospective study.
    Autorzy: Makowiec-Dąbrowska Teresa, Siedlecka J., Pajszczyk-Kieszkiewicz T., Wierzbowski T.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.231-241, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The objective of the study was to define the association between mood state of pregnant women and pregnancy outcome. The study was carried out in a group of 39 women with normal singleton pregnancy. The mood state was assessed twice, around 13 and around 30 week of gestation (GW) using the profile of mood state (POMPS) test. At the same time, information on the course of pregnancy, work loas at workplace and at home, life situation, life style and pregnancy history was collected A negative mood was observed in 20 women at the beginning of pregnancy, and in 17 women around 30 GW. The mood state at the beginning of pregnancy had no significant impact on pregnancy outcome. But the presence of negative mood around 30 GW was found to be and independent risk factor of birthweight below 3000 g (OR = 8.95; 95 p.c Cl: 140 - 57.18) and the relationship between body mass and gestational age below 33rd centile (OR - 5.46; 95 p.c. Cl: 1.01 - 29.47). A negative mood also elevated, albeit insignificantly, the risk of termination of pregnancy before 38 GW. The differences between birthweight, duration of pregnacny and assessment of birthweight respective to gestational age in infants born to women who experienced positive or negative mood around 30 GW was around 445 g; 1.7 weeks; and 20th centile, respectively. All these differences were statistically significant. The results of the study show that the assessment of the mood state may be useful in planning interventions focused on reducing the risk of adverse pregnancy outcome.


    1625/2523

    Tytuł oryginału: Infertility and oxidative stress: is there a connection?
    Autorzy: Szczepańska Małgorzata, Koźlik J., Skrzypczak J., Mikołajczyk M.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.243-251, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Oxidative stress, that is impairment in homeostasis leading to an increase in stationary level of reactive oxygen species, may have serious consequences for the organism Last years' research was focused on answering the question whether oxidative stress might be a cause of infertility This subject concerns mainly women with so-called idiopathic infertility. The aim of this study was to assess the activity of glutathione peroxidase, superoxide dismutase, total antioxidant potential and lipid peroxides in peritoneal fluid from fertile and infertile women. The material was divided into three groups: patients with idiopathic infertility, infertile patients diagnosed with PCO and control - fertile patients, without any pathology within the pelvis. In a group of patients with idiopathic infertility we noted the highest activity of antioxidant enzymes which was accompanied by a rise in total antioxidant status. The results of our research did not confirm the role of antioxidant stress in the pathogenesis of infertility in women with an unexplained cause of infertility. Women with idiopathic infertility are probably too heterogeneous. At this moment the cause of infertility in this group of women cannot be explained by inappropriate antioxidant defense or by lowered activity of enzymes of the antioxidant system.


    1626/2523

    Tytuł oryginału: Recombinant DNA templates as a competitive internal standard in qualitative PCR for human papillomavirus detection in cervical cytology.
    Autorzy: Łukaszuk Krzysztof, Liss J., Wójcikowski C.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.253-260, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Introduction: Persistent genital infection with a "high oncogenic risk" type of human papillomavirus (HPV) is considered to be essential for development of most cervical carcinomas. Therefore, HPV DNA detection in cervical cells could be helpful in prevention and treatment of cervical cancer. Materials and methods: We describe here a simple method for qualitative estimation of the quantity of HPV DNA in cervical smears using polymerase chain reaction (PCR) with internal standard (IS). The assay uses a homologous internal standard (IS), a plasmid containing a modified fragment of E6 HPV16 sequence that is co-amplified with the wild-type target sequence in the same vial and with the same pair of primers. Results: The co-amplification reaction generates two fragments of different size that can be clearly distinguished by gel electrophoresis without a need of restriction enzyme digestion. Conclusions: This method minimises the variability of the efficiency of the PCR technique. Application of these qualitative PCRs is useful for clinical follow-up and could be helpful for elucidating the pathogenic roles of HPV in cervical cancer.


    1627/2523

    Tytuł oryginału: Cytochrome P450c17ŕ gene (CYP17) polymorphism and endometrial cancer risk.
    Autorzy: Romanowicz-Makowska Hanna, Smolarz B., Stetkiewicz T., Pertyński T.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.261-264, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Objective: The established risk factors for endometrial cancer show that exposure to estrogens unopposed to progestins can predict the risk of endometrial cancer. CYP17 encodes the enzyme cytochrome P45c17, which catalyses steroid 17ŕ-hydroxylase and 17 - 20 lyase activities at key points in estrogen (estradiol) biosynthesis. We investigated the association between an A1/A2 polymorphism in the promoter regions of CYP176 gene and the occurrence of endometrial cancer among women who had never used hormone replacement therapy. Patients and methods: Tumour tissues were obtained from 44 postmenopausal women with endometrial cancer. Blood samples from 100 age matched healthy women served as control. The A1/A2 polymorphism was determined by PCR-based MvaA1 restriction fragment length polymorphism. Results: The distribution of the genotypes in cancer patients and control did not differ significantly (p 005) from those predicted by Hardy-Weinberg distribution. Additionally, there were no differences in the frequencies of the A1 and A2 alleles between patients and controls. Conclusion: Our results suggest that the A1/A2 polymorphism may not be associated with endometrial cancer but further research performed on larger population is needed to clarify this point.


    1628/2523

    Tytuł oryginału: Antioxidant status after abdominal hysterectomy with and without closing of peritoneum: a pilot study.
    Autorzy: Szymczyk Grzegorz, Bełtowski J., Marciniak A., Maciejczyk-Pencuła M., Kotarski J.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.265-270, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Objective: The concentration of free radicals in blood rises in response to surgical trauma. There is no data in literature about comparison of oxy-radicals levels and antioxidant status between patients operated with closed or nonclosed parietal and visceral paritoneum. Material and methods: We decided to evaluate the antioxidant capacity of serum in connection with the short-term clinical outcome in 17 women undergoing abdominal hysterectomy with or without peritoneal closure. Results: There was no difference in total antioxidant capacity of serum between analysed two groups of patients either 8 or 24 hours after versus those found before the surgical intervention. Levels of peroxidation intensity markers were higher in patients with closed than in patients with non-closed peritoneum. There were no significant differences in postoperataive recovery in both groups of patients. Conclusion: We confirmed observations of other investigators that peritoneal closure could be abolished at abdominal hysterectomy without an influence on patients' well being.


    1629/2523

    Tytuł oryginału: Pregnancy and delivery in patients with factor V Leiden mutation. A case report.
    Autorzy: Smolarczyk Roman, Pokrzepa-Opuchlik M., Czajkowski K., Broś M., Wójcicka-Bentyn J., Grymowicz M.
    Źródło: Pol. J. Gynaecol. Investig. 2002: 5 (1) s.271-274, bibliogr. 17 poz.
    Sygnatura GBL: 313,538

    Hasła klasyfikacyjne GBL:
  • genetyka
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Before the discovery of activated protein C resistance (APCR), nearly 40 percent of all cases of venous thromboembolism were classified as idiopathic. More than 90 percent of the cases of activated protein C resistance are caused by the factor V Leiden mutation. Mutated factor V is resistant to proteolytic inactivation by activated protein C and retains its procoagulant activity and thus predisposes to thrombosis. Recent studies have also pointed to evidence of an association between factor V Leiden mutation and pregnancy complications such as: hypertensive disorders, first and second trimester miscarriage, placental infarction and placental abruption. The aim of this article is to present pregnancy and delivery in a 23-year-old patient with diagnosed factor V Leiden mutation and thrombophlebitis in medical history.


    1630/2523

    Tytuł oryginału: Epidemiology of football - related injuries. P. 1.
    Tytuł polski: Epidemiologia urazów w piłce nożnej.
    Autorzy: Adamczyk Grzegorz, Luboiński Łukasz
    Źródło: Acta Clin. 2002: 2 (3) s.236-250, il., tab., bibliogr. 32 poz., streszcz.
    Sygnatura GBL: 313,595

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Piłka nożna jest jednym z najpopularniejszych, jeśli nie najpopularniejszym sportem na świecie. FIFA jednoczy 203 organizacje narodowe i zrzesza ponad 200 milionów zarejestrowanych graczy, w tym 40 mln kobiet. Mianem urazu sportowego określa się wszystkie uszkodzenia tkanek dokonujące się w czasie treningu sportowego lub gry. Najczęściej stosowanym kryterium uznania urazu sportowego jest konieczność zrezygnowania z minimum jednego dnia treningu lub gry. Koncepcja urazu sportowego różni się od standardowej, gdyż ludzie nie trenujący wyczynowo uznawani są za zdrowych, gdy mogą wykonywać bez przeszkód swoje codzienne obowiązki. Sportowiec musi być zdolny do gry czy treningu na najwyższym poziomie. Dokładna liczba urazów sportowych jest często trudna do oceny, gdyż nierzadko zależy od wielu czynników, takich jak: motywacja, odnotowanie urazu przez lekarza ekipy (jeśli taki w ogóle jest), stopnia świadomości gracza i terenera. Prawdopodobnie wiele wypadków nie jest w ogóle odnotowywanych, gdy gracz obawia się, że zostanie uznany za nie w pełni sprawnego, odsunięty od gry, itp. Narodowy System Rejestrujący Urazy Sportowe w USA (NAIRS) uznaje za uraz "odnotowany uraz, który ogranicza możliwość treningu lub gry przez minimum 1 następujący dzień" i dzieli je na lekkie (1 - 7 dni), umiarkowane (8 - 21) i poważne (ponad 21 dni). Rada Europy zaproponowała definicję urazu sportowego jako wynik uczestniczenia w zajęciach sportowych mający jedną lub więcej z powyższych ...

    Streszczenie angielskie: Football (soccer) is one of the most popular sports in the world. Currently FIFA unifies 203 national associations and represents about 200 million active players, of which about 40 million are women. The incidence of football injuries is estimated to be 10 - 35 per 1000 game hours. One athlete plays on average 100 hours of football per year (from 50 hours per player of a local team, up to 500 hours per player for a professional team). So every player will have minimum one performance-limiting injury per year. High-velocity trauma and direct contact between sportsmen have made of football a kind of a combat sport, connecting both the consequences of chronic overuse and acute injuries. National Athletic Injury Registration System (NAIRS) in the USA precise "The reportable injury is one that limits athletic participation for at least one day after the day of onset". The review of literature suggests the following: - the data of all studies are similar, - the majority of injuries in prospective studies involve the lower extremity (75.4 - 93 p.c.), in retrespective studies (64 p.c. - 86 p.c.), - head/spine/trunk injuries occur more often than upper extremity injuries. Data from porspective studies indicate, that the most frequently injured on the lower extremity were the ankle (170 - 26 p.c.), and knee (17 - 23 p.c.). In youth players the most affected by the injury was the lower extremity (61 p 89 pc.), followed by the head/trunk/spine (9.7 - 24.8 p.c.) and the upper ...


    1631/2523

    Tytuł oryginału: Data to the phytochemical evaluation of moldavian dragonhead (Dracocephalum moldavica L., Lamiaceae).
    Tytuł polski: Badania nad fitochemiczną oceną lalemancji mołdawskiej (Dracocephalum moldavica L., Lamiaceae).
    Autorzy: Kakasy A. Z., Lemberkovics E., Kursinszki L., Janicsak G., Sz”ke E.
    Źródło: Herba Pol. 2002: 48 (3) s.112-119, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Lelemancja (fałdzistka) mołdawska (Dracocephalum moldavica L., Lamiaceae) jest roczną rośliną rosnącą w Azji Środkowej i aklimatyzowanej we Wschodniej i Środkowej Europie, gdzie jest używana w medycynie ludowej jako lek antyseptyczny i pobudzający. Autorzy przeprowadzili jakościowe i ilościowe badania fitochemiczne ziela lalemancji mołdawskiej i otrzymanych z niego wyciągów (nalewki i naparu). Próbki ziela zbierano w różnych stadiach rozwoju rośliny uprawianej na Węgrzech i w Rumunii (Siedmigród). W zielu zbieranym podczas owocowania rośliny zawartość olejku wynosiła 0,83 proc. W olejku tym za pomocą chromatografii gazowej stwierdzono występowanie 5 głównych składników: octanu geranylu (33,1 proc.), geranialu (28,2 proc.), neralu (19,8 proc.), geraniolu (8,2 proc.) i octanu nerylu (2,4 proc.). W olejku eterycznym oddestylowanym z nalewki głównym składnikiem był octan geranylu (58,2 proc), a w olejku oddestylowanym z naparu głownym składnikiem był geraniol (60,1 proc.). Wyciąg metalonowy z ziela lalemancji był badany za pomocą HPLC. Stwierdzono występowanie 5 głównych składników flawonoidowych i kwasu rozmarynowego. Zawartość dwóch kwasów fenolowych (kawowego i rozmarynowego) oznaczono przy użyciu chromatografii cienkowarstwowej i densytometrii. Wysoką zawartość związków fenolowych stwierdzono w próbkach zebranych w trakcie fazy rozwojowej rośliny, w tym kwasu rozmarynowego (2,84 mg proc.), kwasu kawowego (50,3 mg proc.), ogólnej puli flawonoidów (0,58 g proc.) i ...

    Streszczenie angielskie: The moldavian dragonhead (Dracocephalum moldavica L., Lamiaceae) is an annual plant native in Central Asia and naturalized in Eastern and Central Europe it is used in folk medicine as antiseptic and stimulating remedy We carried out qualitative and quantitative phytochemical investigations on moldavian dragon-head herb and on its extracts (tincture and infusion). Plant samples were gathered in different stages of the ontogenesis from cultures in Hungary and Romania (Transylvania). In herb gathered during the reproductive stage of the ontogenesis we measured 0.85 p.c. (v/m) of essential oil, in which we identified by GC analysis five main components: geranyl acetate: 33.1 p.c; geranial: 28.2 p.c; neral: 19.8 p.c.; geraniol: 8.2 p.c. and neryl acetate: 2.4 p.c. In the essential oil distilled from tincture the geranyl acetate (58,2 p.c.) was the main component while in the volatile oil distilled from infusion, the major compound was geraniol (60.1 p.c.). A methanolic extract of the herb investigated by HPLC. Following on-line analysis of spectra, five componants were classified as flavonoids; rosmarinic acid was idenrified by addition of authentic standard. The amount of two phenol carboxylic acids (caffeic and rosmarinic acid) was measured by TLC-densitometry. High values of phenolic compounds were measured in samples gathered during the vegetative stage of the ontogenesis, such as: rosmarinic acid: 2.84 g p.c.; caffeic acid: 50.3 mg p.c.; total flavonoids: 0.58 g ...


    1632/2523

    Tytuł oryginału: Preliminary report on phytochemistry of medicinal plant Rhodiola Kirilowii (Regel.) Maxim.
    Tytuł polski: Wstępne badania fitochemiczne rośliny leczniczej Rhodiola Kirilowii (Regel.) Maxim.
    Autorzy: Pietrosiuk A., Zych M., Kozłowski J., Furmanowa M.
    Źródło: Herba Pol. 2002: 48 (3) s.136-145, il., bibliogr. 23 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Wyciąg z korzeni kilkuletniej rośliny Rhodiola Kirilowii został poddany badaniom fitochemicznym metodą HPLC. Ich celem było znalezienie aktywnych związków: salidrozylu, tyrozolu, rozawiny, alkoholu cynamonowego i triandryny. W badanych ekstraktach nie znaleziono żadnej z wymienionych substancji. Na chromatogramach zaobserwowano natomiast występowanie piku (Rt 8,9 min., o największej absorbancji przy lambda = 220 nm) niezidentyfikowanej substancji. Dalsze badania w toku.

    Streszczenie angielskie: Extracts of Rhodiola Kirilowii plant roots (several years old plant) were studied by HPLC methods. The aim of these studies was searching for active substances: salidroside, tyrosol, rosavin, cinnamyl alcohol and triandrine. In studied extracts mentioned above substances were not found. On chromatograms only peak (Rt 8,9 min., maximal absorbance at lambda = 220 nm) of notidentified substance was observed. Further investigations are in progress.


    1633/2523

    Tytuł oryginału: Estimation of macrophage IL-10 and NO secretion in the cytotoxicity against transplantable melanomas in relation to the progression of these tumours.
    Autorzy: Kozłowska Krystyna, Cichorek Mirosława, Zarzeczna Małgorzata
    Źródło: Folia Morphol. 2002: 61 (3) s.127-131, il., bibliogr. 28 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki
  • płeć męska

    Streszczenie angielskie: The relationship between the secretion of interleukin 10 (IL-10) and nitric oxide (NO) by hamster peritoneal marcophages and their cytotoxic effects on the cells of those two melanoma lines was studied. The nonuniform reaction of macrophages from hamsters bearing two transplantable melanoma lines has been observed. An increase in the cytotoxicity of macrophages from hamsters bearing the amelanotic melanoma line was accmpanied by an inverse correlation between IL-10 and NO secretion. Such a relationship was not found in the case of macrophages from animals bearing the native-melanotic melanoma line. It is suggested that the phenotypical changes of melanomas connected with their progression modified the cytotoxic and secretory activity of the macrophages with regard to IL-10 and NO.


    1634/2523

    Tytuł oryginału: Assessment of a gastric arterial network for oesophageal substitute by means of pulse oximetry.
    Autorzy: Dąbrowski Andrzej, Ciechański Aleksander, Wallner Grzegorz, Ćwik Grzegorz, Kos Marek, Maciejewski Ryszard
    Źródło: Folia Morphol. 2002: 61 (3) s.133-136, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • onkologia
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Insufficient vascularisation of substitutes in the operative reconstruction of the oesophagus is one of the main causes of the occurrence of anastomotic leaks. In the present study, the blood oxygenation of gastric substitutes for the oesophagus was evaluated before and during the reconstruction. A pulse oximeter was used for the assessment (S&J Medico Teknik AIS, Albertslund, Denmark). Oxygenation in the examined places ranged from 79 p.c. to 98 p.c. The values of blood oxygenation in places C1 (fundus of the stomach after the formation of the substitute) and C2 (fundus of the stomach after the formation and stretching of the substitute) were significantly lower than those in analogous places in the stomach before the transformation (C/C1 p 0.02; C/C2 p 0.03, Fisher test). There were no correlations between pulse oximetry values observed and the presence of anastomosis leak.


    1635/2523

    Tytuł oryginału: Pecam-1 expression in patients with relapsing-remitting multiple sclerosis.
    Autorzy: Niezgoda Adam, Losy Jacek
    Źródło: Folia Morphol. 2002: 61 (3) s.143-145, tab., bibliogr. 18 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: PECAM-1 is an adhesion molecule - a member of the immunoglobulin superfamily -involved in the transendothelial migration of leukocytes PECAM-1 is expressed on lymphocytes, monocytes and granulocytes. It is also found on endothelial cells and platelets. We present data showing that the cell-bound form of PECAM-1 expression on monocytes is increased in MS patients, compared to controls. We also show that PECAM-1 is significantly over-expressed on lymphocytes in patients with active MRI lesions, when compared to those without gadolinium - enhancing lesions. Our results suggest that the cell-bound form of PECAM-1 can be regarded as a marker of MS activity.


    1636/2523

    Tytuł oryginału: Asymmetry of the ovale and spinous foramina in mediaeval and contemporary skulls in radiological examinations.
    Autorzy: Teul Iwona, Czerwiński Florian, Gawlikowska Aleksandra, Konstanty-Kurkiewicz Violetta, Sławiński Grzegorz
    Źródło: Folia Morphol. 2002: 61 (3) s.147-152, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • historia średniowiecza
  • historia nowożytna
  • historia XX wieku

    Streszczenie angielskie: The aim of this work was to evaluate the morphology and asymmetry of the ovale and spinous foramina. Examinations were carried out on 102 mediaeval and 85 contemporary male skulls. In both groups there predominated individuals who had died at mature (maturus) and adult (adutus) age. Radiological images in occipital projection were used in the study. Areas of the the foramina ovale, distances between both openings and the distance from the midline running through the middle of the occipital foramen were calculated by means of PC software. The spinal foramen area could not be measured because of the too small surface accessible to the PC software used in our study Correlation between the above measurements and cranial indexes (width-lenght and height-length) were calculated. Significant variety of the ovale and spinous foramina in size, shape, relation to each other and to the midline were analysed. Asymmetry of structure and location was observed in both examined groups of skulls. No cases of the lack of the ovale and spinous foramina were stated.


    1637/2523

    Tytuł oryginału: Three-dimensional reconstruction of the lentiform nucleus from serial sections in man.
    Autorzy: Selcuk Src H., Mustafa Aldur M., Hamdi Celik H.
    Źródło: Folia Morphol. 2002: 61 (3) s.153-156, il., bibliogr. 6 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Three-dimensional (3-D) reconstruction of the lentiform nucleus was performed by using serial macroscopic anatomic sections, taken from a human cadaver. When the rendered form of this wire-frame reconstruction was examined, it was found that both the putamen and globus pallidus had upper and lower poles. The distances between the upper and lower poles were 2.23 cm in the putamen and 1.45 cm in the globus pallidus. The lower poles of the putamen and globus pallidus were about the same level but the upper pole of the putamen was 0.78 cm higher than in the globus pallidus. The vertical dimension of the leniform nucleus was 22.9 mm. This is the first study reporting the three-dimensional reconstruction and the dimensions of the lentiform nucleus of the human brain. We believe that this study will be of help in future studies concerning the lentiform nucleus and its relations.


    1638/2523

    Tytuł oryginału: Professor Mirosław Jan Mossakowski (1929-2001).
    Autorzy: Imieliński Brunon L.
    Źródło: Folia Morphol. 2002: 61 (3) s.157-159, il.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • historia nowożytna
  • historia XX wieku
  • historia XXI wieku

    Temat osobowy:
  • Mossakowski
  • Mirosław Jan 1929-2001


    1639/2523

    Tytuł oryginału: Papers presented during 3rd Conference of Clinical Anatomy of the Polish Anatomical Society. [Abstracts.]
    Opracowanie edytorskie: Grzybiak Marek (Oprac.), Kuta Włodzimierz (oprac.).
    Źródło: Folia Morphol. 2002: 61 (3) s.161-190 - 3 Konferencja Anatomii Klinicznej Polskiego Towarzystwa Anatomicznego Gdańsk 2002
    Sygnatura GBL: 301,720

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Polskie Towarzystwo Anatomiczne


    1640/2523

    Tytuł oryginału: Ginekologia Polska
    Tytuł angielski: Gliomatosis peritonei with mature teratoma of the ovary.
    Autorzy: Gabryś Marian, Blok Krystian, Rabczyński Jerzy, Kochman Agata, Łątkowski Krzysztof, Blok Radosław, Godwin Bwire Ekonjo
    Źródło: Ginekol. Pol. 2002: 73 (12) s.1224-1227, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 301,184

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Praca prezentuje przypadek olbrzymiego, dojrzałego potworniaka jajnika z rozsiewem tkanki glejowej w obrębie otrzewnej i jej wytworów. Po usunięciu nowotworu i sieci większej, wykonano kontrolne badanie laparoskopowe stwierdzając redukcję utkania guzków glejowych z ich włóknieniem oraz wybitnym odczynem komórkowym w sąsiedztwie.

    Streszczenie angielskie: We report a case of monstrual mature teratoma of ovary with implants of glial tissue in peitoneum and its adnexa. After resection of the tumour and omentum laparoscopic examination was performed and revealed reduction, fibrosis of glial implants and massive cellular reaction.


    1641/2523

    Tytuł oryginału: Health care reform in Poland. Introduction of the Social Health Insurance.
    Autorzy: Król Zbigniew J.
    Źródło: Zdr. Zarz. 2002: 4 (5) s.156-162, streszcz.
    Sygnatura GBL: 313,596

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • ekonomika

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie polskie: W artykule autor przedstawia własny pogląd na temat wprowadzonej w Polsce reformy finansowania ochrony zdrowia. Zmiana finansowania została opisana na tle systemu opieki zdrowotnej, który funkcjonował przed wejściem Ustawy o powszechnym ubezpieczeniu zdrowotnym w 1999 roku, poświęcając szczególną uwagę roli samodzielnych zakładów opieki zdrowotnej. Przedstawiono analizę wpływu zmiany sposobu finansowania na funkcjonowanie poszczególnych szczebli systemu.

    Streszczenie angielskie: The implementation of the health sector reforms was not well received by the public or many of the provides themselves. The introduction of an obligation to obtaine fererral to consult a specialist brought about a sense of restricted access. Even in regions where the system of referrals had existed for a long time, there were complaints related to problems in obtaining referrals. It was widely preceived that doctors were 'conomizing on patients' by not issuing referrals while using economic arguments to deny them. In truth, however, only a few Sickness Funds required primary care physicians the cost of specialist consultations and diagnostic tests. The sense of limited access was largely due to the fact that the Sickness Funds purchased a specific number of services (called limits). Those limits pertained to both specialist outpatient care and inpatient treatment. Publicized throught 1999, there were widespread reports of patients being sent back and forth, from hospital to hospital which, despite being infrequent relative to the total number of services performed in Poland, added to the impression of huge errors in reform implementation. The poor financial situation of some health ficilities added to the general confusion and the impressions that health reforms had failed to curb the ever-growing debst. Highly exaggerated stories circulated of hospitals or health care centres standing on the brink of bankruptcy. They were not supported by facts or supplemented with information on the actual causes of problems that were most often connected with the lack of...


    1642/2523

    Tytuł oryginału: Quality improvement in family medicine. Training of Tutors in Family Medicine.
    Autorzy: Król Zbigniew J., Wolańczyk Jan
    Źródło: Zdr. Zarz. 2002: 4 (5) s.170-171, streszcz.
    Sygnatura GBL: 313,596

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Kolegium Lekarzy Rodzinnych

    Streszczenie polskie: W artykule opisano zorganizowany przez Kolegium Lekarzy Rodzinnych w Polsce program powstawania grup rówieśniczo-koleżeńskich. Grupy te tworzone i prowadzone przez lekarzy rodzinnych, absolwentów Szkoły Tutorów. Zadaniem grupy jest wspólne wdrażanie programów poprawy jakości. W artykule przedstawiono cele i sposób kształcenia Tutorów w przeprowadzonych już dwóch edycjach szkolenia

    Streszczenie angielskie: The article describes the program whose aim is to establish peer-review group organized by College of Family Doctors in Poland. Those groups are created and led by family doctors, alumni of the School of Tutors. The goal of the group is to work together and umplement quality improvement programs. The article presents objectives and training procedures in education of Tutors in two completed editions of training courses.


    1643/2523

    Tytuł oryginału: The National Health Found - the governmental proposal for changes in the Polish health care system.
    Autorzy: Juszczyk Grzegorz
    Źródło: Zdr. Zarz. 2002: 4 (5) s.175-176
    Sygnatura GBL: 313,596

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • ekonomika

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny


    1644/2523

    Tytuł oryginału: 2nd Symposium "Progress in molecular diagnosis and treatment of genetic based pediatric malignancies".
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.1-74, il., tab., bibliogr. [przy artyk.] - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południowe 08-09.05. 2002 - Część mater. zamieszczono w formie streszcz.
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Polska Unia Onkologii


    1645/2523

    Tytuł oryginału: Vascular tumors: the many faces of vasculogenesis and angiogenesis.
    Autorzy: Zimmermann Arthur
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.9-16, bibliogr. 76 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południowe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Vascular tumors are frequent lesions with a compleks morphology and a broad spectrum of clinical presentation. They have, therefore, been studied in considerable detail with respect to their biology and pathology, but the understanding of pathogenic mechanisms involved had to await progress in vascular biology. During the last years, an impressive amount of knowledge relating to vasculogenesis and angiogenesis has accumulated, and numerous genes and factors operational in vascular morphogenesis have been identified. The elucidation of these critical mechanisms has an increasing and interesting impact on the uncovering of pathogenic pathways active in vascular tumours. Several important aspects of this field are summarized in the present overview.


    1646/2523

    Tytuł oryginału: Differentiated thyroid cancer: from molecular biology to clinical practice.
    Autorzy: Jarząb Barbara, Włoch Jan, Lange Dariusz, Wiench Małgorzata, Gubała Elżbieta
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.17-20, bibliogr. 47 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południowe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Two main histotypes of thyroid carcinoma - papillary carcinoma and follicular carcinoma - derive from the same cell type but exhibit different routes of molecular development. In papillary carcinoma, receptor kinase encoding protooncogenes RET or TRK play main role in the initiation of tumorigenesis. Their rearrangements have been found in circa 25 p.c. and 10 p.c. of tumors respectively. The initiating event in the remaning part of papillary cancers remains unknown. Some of RET negative cancers may develop towards anaplastic carcinoma, as RET rearrangements have never been observed in this type of cancer. Follicular carcinomas develop from follicular adenomas. RAS mutations are found in a substantial part of benign and malignant follicular tumors, more frequently in iodine-deficient areas. The molecular event criucial for the transition from adenoma to carcinoma remains a matter of debate. Recently a PAX8-PPARç1 rearranggement has been proposed to be essential for this step of tumorigenesis. Finally, loss of TP53 is a common feature of undifferentiated thyroid cancers, responsible for their aggressive phenotype. RET rearrangements are very frequent in thyroid cancers observed in contaminated areas of Belarus, Ukraine and Russia after Chernobyl fall out. It is not clear, whether they are molecular fingerprints of radiation or are signs of an early onset of cancer. The prognosis significance of RET-positivity is also unspecified. RET mutations have been reported with higgher frequency in more advanced cancer, on the other side, RET-positive cancers probably do not proceed towards undifferentiated carcinoma.


    1647/2523

    Tytuł oryginału: Hepatocellular carcinoma: the pathway from progenitor cells to novel entities.
    Autorzy: Zimmermann Arthur
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.21-26, bibliogr. 55 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Malignant liver cell tumours, and in particular hepatocellular carcinomas, exhibit a broad array of growth patterns and types of differentiation. Apart from well established types and subtypes, novel morphocytes have recently emerged, and their identification is important for both, the clinical setting and theoretical considerations. In particular, unique pathways of diferentiation occuring in liver tumors may reflect distinct phases of hepatic ontogenesis. In the present overview, recently uncovered aspects of hepatogenesis are discussed in relation to the pathogenesis of special and in part novel types of malignant liver cell tumours.


    1648/2523

    Tytuł oryginału: Hepatocellular carcinoma in children - treatment perspectives on the basis of international SIOPEL-1 trial experience.
    Autorzy: Czauderna Piotr
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.27-33, il., tab., bibliogr. 43 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Introduction: Hepatocellular carcinoma (HCC) is the second most common malignant liver neoplasms (after hepatoblastoma) in the pediatric population. Objectives: To present information on outcome and prognosis of pediatric HCC and to discuses eventual treatment strategies. Material: Forty patients diagnosed with hepatocellular carcinoma (HCC) were registered in the SIOPEL-1 study from 1990 to 1994 (39 were evaluable). Metastases at diagnosis occurred in 31 p.c. children. Multifocal tumors prevailed (56 p.c.). 37 patients received preoperative chemotherapy (PLADO - cisplatin and doxorubicin). Results: Partial response was observed in 18/37 cases (49 p.c.). Complete tumor resection was achieved in 14 patients (36 p.c.) (including 2 liver transplantations). Twenty cases (51 p.c.) never became operable. Overall survival (OS) at 5 yrs is 28 p.c., while event free survival (EFS) in 17 p.c. The overall poor treatment results of HCC patients were mainly due to advanced tumor stage and low rate of complete excision. In multivariate analysis metastates and high PRETEXT grouping were identified as adverse prognostic factors. Despite fairly high response rate to preoperative chemotherapy over 50 p.c. of tumors remained inoperable. Different therapeutic options in HCC, including: surgery, transplantation, tumor embolization and chemoembolization, ethanol injection, immuno- and hormonotherapy, as well as antiangiogenic therapy, are presented and discussed. Conclusions: 1. Generally poor survival in pediatric hepatocellular carcinoma at modern standards of care...


    1649/2523

    Tytuł oryginału: Cytogenetics and molecular genetics of sarcomas.
    Autorzy: Kazanowska Bernarda
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.35-38, bibliogr. 18 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: A significant amount of research in both molecular genetics and cytogenetics is devoted to the study of genetic changes that occur during malignant transformation. Genes that contribute to tumorigenesis fall into: oncogenes, tumor supressor genes and those that protect the integrity of the genome. A number of soft tissue tumor translocations have been characterized at the molecular level and all result in the formation of fusion proteins. Many of the translocation-encoded fusion genes are transcription factors in adipose tumor, PNET and Ewing sarcoma fibrosarcoma congenital rhabdomyosarcoma alveolar and synovial sarcoma. The p53 mutation gene has been identified in Li-Fraumeni syndrom which is predisposed to a characteristic constellation of tumours: bone and soft tissue sarcomas, brain tumours, breast cancer, adrenal cortical carcinoma and leukemia. Chromosome translocations can provide for identifying genes that are involved in this process and are diagnostic for particular tumor types. The most diagnostically useful aberration in malignant tumors are translocations : t(12;16)(q13;p11) in liposarcomas, t(11;12)(p13;q11-12) in desmoplastic small round-cell tumor, t(11;22)(q24;q12) in PNET/Ewing sarcoma, t(12;15)(p13;q26) in fibrosarcoma congenital, t(12;13) in alveoral rhabdomyosarcoma and t(X;18)(p11;q11) in synovial sarcoma. The important mechanism of oncogene activation in soft tissue sarcoma is MYCN amplification provides to deregulate gene expression and a proliferative advantage tumors. That molecular genetic is the most importance of potential prognostic markers for aggressive tumor, diagnosis and clinical correlative in soft tissue sarcomas.


    1650/2523

    Tytuł oryginału: Current concepts in surgery for soft tissue sarcomas of childhood.
    Autorzy: Godziński Jan
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.39-44, bibliogr. 52 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: Soft tissue sarcomas are heterogenous group of malignancies. It seems most useful to divide those tumours and guide the treatment regarding its chemosensitivity. Surgery remains important part of the treatment, but its role is different in each chemo-sensitivity group. In chemosensitive tumours primary surgery should not be mutilating. The pre-treatment offers great chance for secondary conservative complete local control. Also in case of a post-surgical micro-residue chemotherapy may help to achieve complete remission. In tumours of possible chemosensitivity, primary surgery offers best chance for long-term survival, however, patients with unresectable tumours may have a chance to be turned operable after pre-treatment. In case of post-surgical residue, chemotherapy alone usually does not offer the chance for long-term survival. Local re-treatment should be considered. In case of tumours of uproven chemosensitivity surgery is most reliable method of treatment and, also mutilating, is the first treatment. Microscopical residue requires either re-excision or radiotherapy. Only in case of very extensive tumours, the trial of chemotherapy may be tested. Concluding: 70-80 p.c. of long term survivors after combined treatment in 1990-ties compared to 20 p.c. after surgery alone in 1930-40-ties indicate the importance of chemotherapy. Experience of high rate of local relapses from 1980-ties after systemic treatment only (up to 40-50 p.c.) evidences changing, but crucial role of surgery.


    1651/2523

    Tytuł oryginału: Surgical treatment of differentiated thyroid carcinoma in children.
    Autorzy: Włoch Jan, Handkiewicz-Junak Daria, Kukulska Aleksandra, Jarząb Barbara
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.45-50, il., bibliogr. 44 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: There is a considerable disagreement on differentiated thyroid cancer (DTC) treatment in children. In most centres standard treatment for DTC comprises total thyroidectomy, radioiodine treatment and TSH suppressive therapy. However, not all agree on such radical therapy due to the minor agressivity of differentiated thyroid cancer in children. The opponents question both the indications for total thyroidectomy and complementary radioiodine treatment. The aim of the present study is a retrospective analysis of treatment results in children treated or followed up in our centre. The study included 205 children with DTC (age 4 to 18) observed up to 27 years post initial treatment (median: 4 years). There were 48 children with follicular ca and 156 with papillary ca diagnosed. The median age at diagnosis was 14 years. The treatment comprised total thyroidectomy in 176 cases (86 p.c.), radioiodine therapy in 80 p.c. and TSH suppressive therapy with levothyroxine in all patients. The actuarial survival rate was 100 p.c. and recurrence rate 10,7 p.c. The 5 and 10 - year actuarial disease free survival was 76 p.c. and 74 p.c. respectively. The results were much poorer in children who were not primarily treated by a radical approach. It is to be concluded that total thyroidectomy and radioiodine treatment significantly improve recurrence free survival in children and should be routinely applied even in young children as the primary treatment of differentiated thyroid carcinoma.


    1652/2523

    Tytuł oryginału: Possibilities and limitations in the treatment of hepatocellular carcinoma in children.
    Autorzy: Prokurat Andrzej, Kluge Przemysław, Chrupek Małgorzata, Kościesza Andrzej
    Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (1/2) s.51-55, il., tab., bibliogr. 34 poz. - 2 Sympozjum pt. Postępy w diagnostyce molekularnej i leczeniu nowotworów złośliwych na podłożu genetycznym w pediatrii Zegrze-Południe 08-09.05. 2002
    Sygnatura GBL: 313,395

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: Hepatocellular carcinoma (HCC) is known to be a tumour of older children and adolescence and its closely related to metabolic liver diseases, hepatitis and post HBV/HCV liver cirrhosis. Cirrhosis, multifocal origin of the disease and poor response to chemotherapy are also known limitations in the treatment of HCC. Both traditional surgery and liver transplantation have been applied in the treatment of HCC but the experience in children is still very limited. Indications for each treatment strategies are also not clear in children as the many paediatric patients demonstrate the lack of underlining liver cirrhosis. Possibilities and limitations in the treatment of HCC have been studied in the group of 19 patients treated in the single centre, to assess the results and treatment strategies. The common type of HCC was diagnosed in 14 children and the fibrolamellar variant (FL-HCC) in 5 patients. In 13 children HCC developed secondary to liver cirrhosis and in 11 children history of hepatitis mainly post HBV had been documented. The patients with liver cirrhosis and HCC demonstrated elevated serum level of alfa fotoprotein (AFP), whereas serum AFP of the patients with FL-HCC was within the normal ranges. Eight of 19 children with HCC presented very advanced stage of disease, making surgery impossible. Partial liver resection have been performed in 7 patients. In 5 children with HCC, of whom 4 had liver cirrhosis, orthotopic liver transplantation had been done. Six of 11 operated children are alive. Better prognosis for patients with FL-HCC is suggested. The prognosis for common type of HCC, especially in advanced stages and resulting from liver cirrhosis, despite different approaches remains poor.


    1653/2523

    Tytuł oryginału: Conflict of interest and its significance in science and medicine. The proceedings of an International Conference held in Warsaw.
    Opracowanie edytorskie: Górski Andrzej (Ed.).
    Źródło: Sci. Eng. Ethics 2002: 8 (3) s.257-474, il., tab., bibliogr. [przy artyk.] - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1654/2523

    Tytuł oryginału: Conflict of interest and its significance in science and medicine.
    Autorzy: Górski Andrzej
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.216-262, bibliogr. 7 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1655/2523

    Tytuł oryginału: Ludwik Hirszfeld: scientist and humanist.
    Autorzy: Balinska Marta Aleksandra
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.269-271 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca biograficzna

    Temat osobowy:
  • Hirszfeld
  • Ludwik 1884-1954


    1656/2523

    Tytuł oryginału: Conflicts of interest in science and medicine: the physician's perspective.
    Autorzy: Human Delon
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.273-276, bibliogr. 9 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1657/2523

    Tytuł oryginału: The council of Europe's instruments on biomedical research: how is conflict of interest addressed?
    Autorzy: Zilgalvis Peteris
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.277-281 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    1658/2523

    Tytuł oryginału: Good medical research - the view of the CDBI/Council of Europe.
    Autorzy: Doppelfeld Elmar
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.283-286, bibliogr. 2 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1659/2523

    Tytuł oryginału: Conflicts of interests and access to information resulting from biomedical research: an international legal perspective.
    Autorzy: Byk Christian
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.287-290 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1660/2523

    Tytuł oryginału: Conflicts of interest in science in Armenia.
    Autorzy: Nersesyan Armen K.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.291-293 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1661/2523

    Tytuł oryginału: Funding, objectivity and the socialization of medical research.
    Autorzy: Brown James Robert
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.295-308, bibliogr. 14 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1662/2523

    Tytuł oryginału: Conflict of interest in Croatia: doctors with dual obligations.
    Autorzy: Vrhovac Bozidar
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.309-316, bibliogr. 7 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1663/2523

    Tytuł oryginału: Conflict of interest in medical research in Estonia.
    Autorzy: Tikk Arvo
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.317-318, bibliogr. 3 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1664/2523

    Tytuł oryginału: Moderm medicine and biotechnology: an ethical conflicts of interest?
    Autorzy: Jansen Brigitte
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.319-325, bibliogr. 8 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1665/2523

    Tytuł oryginału: Conflicts of interest in Germany: a legal perspective.
    Autorzy: Lux Christina
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.327-336, bibliogr. 29 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1666/2523

    Tytuł oryginału: Conflict of interest as seen from a researcher's perspective.
    Autorzy: Schieppati Arrigo, Perico Norberto, Remuzzi Giuseppe
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.337-342, bibliogr. 22 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1667/2523

    Tytuł oryginału: Conflict of interest in medicine and science: a Latvian view.
    Autorzy: Rudze Laime
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.343-348, bibliogr. 2 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1668/2523

    Tytuł oryginału: Conflict of interest in medicine in Lithuania: legal and ethical aspects.
    Autorzy: Virbalis Rytis
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.349-352 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1669/2523

    Tytuł oryginału: Conflict of interest issues in informed consent for research of human subjects: a South Asian perspective.
    Autorzy: Jafarey Aamir M.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.353-362, tab., bibliogr. 18 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1670/2523

    Tytuł oryginału: Conflict of interest from Romanian geneticist's perspective.
    Autorzy: Ispas Ioana
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.363-381, il., tab., bibliogr. 23 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1671/2523

    Tytuł oryginału: Conflict of harmony? Clinical research and the medical press in Russia.
    Autorzy: Lichterman Boleslav
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.383-386, bibliogr. 5 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1672/2523

    Tytuł oryginału: Conflicts of interest between Eastern and Western scientific systems.
    Autorzy: Klestova Zinayida, Makarenko Alexander
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.387-392, bibliogr. 10 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1673/2523

    Tytuł oryginału: Conflict of interest: the importance of potential.
    Autorzy: Evans Imogen
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.393-396, bibliogr. 3 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1674/2523

    Tytuł oryginału: The continuing need for disinterested research.
    Autorzy: Ziman John
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.397-399 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1675/2523

    Tytuł oryginału: Managing financial conflicts of interest in clinical research.
    Autorzy: Cohen Jordan J.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.401-406 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1676/2523

    Tytuł oryginału: Who owns the data in clinical trial?
    Autorzy: Drazen Jeffrey M.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.407-411, tab., bibliogr. 5 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1677/2523

    Tytuł oryginału: The impact of conflict of interest on trust in science.
    Autorzy: Friedmann Paul J.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.413-420, bibliogr. 15 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1678/2523

    Tytuł oryginału: Individual and institutional conflict of interest: Policy review by research Universities in the Unitet States.
    Autorzy: Hasselmo Nils
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.421-427, bibliogr. 8 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1679/2523

    Tytuł oryginału: Conflicts of interest in drug development: the practices of Merc and Co., Inc.
    Autorzy: Hirsch Laurence J.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.429-442, il., tab., bibliogr. 42 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1680/2523

    Tytuł oryginału: Academic-industrial relationships: opportunities and pitfalls.
    Autorzy: Martin Joseph B., Reynolds Thomas P.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.443-454, il., tab., bibliogr. 8 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1681/2523

    Tytuł oryginału: Conflict of Interest and medical publication.
    Autorzy: Reidenberg Marcus M.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.455-457, bibliogr. 17 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1682/2523

    Tytuł oryginału: Beyond conflict of interest: the responsible conducts of reasearch.
    Autorzy: Rhoades Lawrence J.
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.459-468, tab., bibliogr. 13 poz., sum. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa


    1683/2523

    Tytuł oryginału: Conference summary "Conflict of interest and its significance in science and medicine".
    Autorzy: Baldwin Wendy
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.469-475, bibliogr. 3 poz. - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • sprawozdanie


    1684/2523

    Tytuł oryginału: Injections of botulinum A toxin for the treatment of anal fissures.
    Autorzy: Trzciński Radzisław, Dziki Adam, Tchórzewski Marcin
    Źródło: Eur. J. Surg. 2002: 168 (12) s.720-723, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 300,370

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Objective: To find out how injections of botulinum A toxin influence the healing of anal fissures. Design: Retrospective study. Setting: Medical University of Lodz, Poland. Subjects: 13 patients (6 women, 7 men), mean age 49 (range 31 - 78), treated with injections of botulinum A toxin 50 units on either side of the anal fissure into the internal anal spincter from May to December 1999. Main outcome measures: Complications and relapse. Results: Seven fissures has healed by one month and four by two months. Two remained unhealed but asymptomatic. There was no incontinence of flatus or faeces after three months of treatment. Resting anal pressure was significantly lower in 10 of 13 patients compared with before treatment (p 0.05). One fissure relapsed after 4 months and this patient had a successful anal stretch. Conclusion: Injection of botulinum A toxin gives good results in the treatment of anal fissures.


    1685/2523

    Tytuł oryginału: Sexual dimorphism in the robusticity of long bones of infants and young children.
    Autorzy: Coussens Anna, Anson Tim, Norris Rachel M., Henneberg Maciej
    Źródło: Prz. Antropol. 2002: 65 s.3-16, il., tab., bibliogr. s. 15, streszcz.
    Sygnatura GBL: 301,512

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.

    Streszczenie polskie: W okresie przedpokwitaniowym dymorfizm szkieletu ludzkiego jest nieznaczny toteż istnieje niewiele metod oznaczania płci na szczątkach szkieletowych małych dzieci i niemowląt. Ze względu na znany dymorfizm płciowy rozmiarów uzębienia i z powodu różnic w wydzielaniu i oddziaływaniu na szkielet hormonów płciowych w czasie życia wewnątrzmacicznego, daje się zaobserwować różnice płciowe w kształceniu trzonu żuchwy dziewcząt i chłopców [LOTH, HENNEBERG 2001]. Wiarygodność oznaczania płci na podstawie trzonu żuchwy sięga zaledwie 81 proc. i należy poszukiwać innych metod oznaczania płci na szkieletach dziecięcych celem podwyższenia rzetelności ocen. Oznaczanie w materiale archeologicznym płci przy pomocy jądrowego DNA, jakkolwiek w niektórych przypadkach możliwe, jest mało użyteczne z powodu niejednakowej trwałości DNA w indywidualnych szczątkach szkieletowych i zróżnicowanego stopnia jego degradacji. Prowadzi to do braku możliwości oznaczania płci wielu osobników. Co więcej, analizy DNA są drogie i niemożliwe do przeprowadzernia w warunkach polowych. W niniejszej pracy przedstawiamy prostą metodę oznaczania płci na podstawie masywności kości długich wyrażonej w postaci wskaźników ilorazowych. Wskaźniki te to stosunek obwodu w środku trzonu do długości maksymalnej trzonu kości (C : ML), stosunek minimalnego obwodu kości ramiennej do długości trzonu (HMC : ML) i stosunek szerokości końca trzonu (metafizy) do maksymalnej długości trzonu (MW : ML). Wskaźniki te zostały określone dla 23 szkieletów dzieci w wieku 0 - 24 miesięcy i jednego dziecka zmarłego w wieku 3 - 4 lat. (Tab. 1 i 2)...

    Streszczenie angielskie: It is difficult to determine the sex of subadult skeletal remains because there is little sexual dimorphism present pre-pubertally. In a historic sample of 24 children aged 0 - 4 years from St. Mary,s Anglican Church, Marion, South Australia, the robustness of femora and of humeri was correlated with sexually dimorphic mandibular morphology. Ratios of midshaft circumference to diaphyseal length of humeri and femora and the ratio of minimum circumference to diaphyseal length of the humerus showed correlation with sex determined by mandibular morphology, male indices being greater than the female ones. The humerus midshaft circumference index showed the greatest difference between sexes (P value = 0.0002). The results need confirmation on known-sex skeletal remains, but for the moment this robusticity dimorphism seems to be a new discovery for osteological practice.


    1686/2523

    Tytuł oryginału: Effect of diurnal variation on body composition under consideration of selected chronobiological marker systems.
    Autorzy: Dittmar Manuela, Raschka Christoph, Koch Horst J.
    Źródło: Prz. Antropol. 2002: 65 s.17-26, il., tab., bibliogr. s. 24-25, streszcz.
    Sygnatura GBL: 301,512

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie polskie: Przedmiotem badań w przedstawionej pracy były zmiany zachodzące w ludzkim organizmie w rytmie dobowym, a w szczególności dzienne zmiany składu ciała. Zmiany te badania na tle zmienności takich markerów chronobiologicznych jak ciśnienie krwi, tętno i temperatura ciała. Pomiary wykonywano czterokrotnie w ciągu dnia, od godziny 5:35 do 0:15 na grupie 27 zdrowych studentów wychowania fizycznego (26 mężczyzn i 6 kobiet) w wieku 22 - 29 lat (średnia wieku 24,9 lat), charakteryzujących się wskaźnikiem BMI (średnio) 23,5 kg/mý. Skład ciała każdego badanego określany był czterokrotnie przy użyciu czterobiegunowego, wieloczęstotliwościowego analizatora bioimpedencji (BIA 2000-M, Data Imput Company, Frankfurt/Main), pracującego przy 800 ćA i dokonującego pomiaru przy czterech stałych częstotliwościach (1, 5, 50, 100 kHz). W trakcie pomiarów badana osoba znajdowała się w leżącej pozycji. Określano dziesięć bezpośrednich i siedem oszacowywanych parametrów składu ciała: rezystancję (R, mierzoną przy trzech częstotliwościach), reaktancję (Xc, przy trzech częstotliwościach), kąt fazowy (PA, przy trzech częstotliwościach), całkowitą wodę organizmu (TBW), wodę zewnątrz- i wewnątrz-komórkową (ECW i ICW), masę ciała szczupłego (LBM), masę pozakomórkową (ECM), masę komórek ciała (BCM) i masę tłuszczu (FM). Zmienność danych dotyczących składu ciała u mężczyzn i kobiet porównano przy użyciu współczynników wariancji (CV). Porównania powtarzanych pomiarów dokonano przy pomocy testu ANOVA Friedmana z testem post hoc Wilcoxina. Zależności między zmiennymi zbadano współczynnikami korelacji Spearmana...

    Streszczenie angielskie: Diurnal variation in body composition in relation to chronobiological parameters was analyzed in 27 healthy students (22 - 29 years) four times over one day from 5:35 to 0:15 h. Body composition was determined by multifrequency bioimpedence analysis at fixed frequencies (1, 5, 50 100 kHz). Resistance (R) and reactance (Xc) were measured. Total, extra and intracellular body water (TBW, ECW, ICW), lean body mass (LBM), and fat mass (FM) were derived, and blood pressure and body temperature were measured. Friedman's ANOVA with post hoc Wilcoxon matched pairs tests revealed a diurnal variability. R and Xc declined in the course of the day. Weight, TBW, ECW, ICW, LBM and ECM increased, whereas height decreased. Chronobiology did not significantly influence FM. Body composition variables displayed inverse associations to RRdiastolic. The diurnal decrease is probably influenced by food and fluid intake. The representative values for body composition should be the morning measures.


    1687/2523

    Tytuł oryginału: Adolescent growth and its relation to menarche, dental and somatic maturation.
    Autorzy: Kaczmarek Maria
    Źródło: Prz. Antropol. 2002: 65 s.27-42, il., tab., bibliogr. s. 39-40, streszcz.
    Sygnatura GBL: 301,512

    Hasła klasyfikacyjne GBL:
  • pediatria
  • stomatologia
  • ginekologia i położnictwo
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było określenie zależności pomiędzy wzrastaniem wysokości ciała w okresie pokwitania a wiekiem menarche, wiekiem zębowym i somatycznym. Współzależności analizowano na podstawie danych dla 181 chłopców i 176 dziewcząt urodzonych w 1980 r. w Poznaniu i okolicy, w średniozamożnych rodzinach, uczestniczących w latach 1985-98 w Poznańskich Badaniach Długofalowych. Badanai o charakterze ciągłym wykonywano dwukrotnie w ciągu roku, zawsze w połowie marca i września. Objęły one okres od 5. do 18. roku życia. Pomiary antropometryczne wykonywano z dużą rzetelnością. Wyliczona z powtórzeń pomiarów wartość błędu intra-subiektywnegob (intra-TEM) dla wysokości ciała wynosiła 0,42 cm, natomiast błędu inter-subiektywnego (inter-TEM) 0,62 cm; wartości te są podobne do cytowanych w literaturze [MALINA et al. 1973, CAMERON 1984, ULIJASZEK i STRICKLAND 1993]. Krzywe wzrastania i punkty krytyczne krzywej dla skoku pokwitaniowego wysokości ciała wykreślono w programie AUXAL, dopasowując do serii indywidualnych pomiarów matematycznych model wzrastania, znany w auksologii jako JPA2 [JOLICOEUR i wsp. 1992]. Dopasowanie modelu do danych pomiarowych okazało się bardzo dobre, o czym świadczy standardowy błąd estymacji SEE równy 0,424 cm, tak jak wartość intra-TEM. Na podstawie wartości współczynników korelacji Pearsona analizowano zależności pomiędzy charakterystykami skoku pokwitaniowego wysokości ciała: wiekiem, osiągniętą wysokością i tempem wzrostu w momencie rozpoczęcia skoku (punkt take off - TO) i szczycie skoku pokwitaniowego (PHV) a miarami dojrzałości fizjologicznej...

    Streszczenie angielskie: Relationships between growth in height during adolescence and menarche, somatic, and dental maturation were analyzed on longitudinal data for 181 boys and 176 girls from the Poznań Growth Study. It was found that the correlation pattern between variables shifts during the spurt indicating the following regularities: The younger and smaller the boys and girls were at the onset of the spurt, and the lower the height velocity at that time, the longer their spurt was likely to last, and the adolescent height increment was langer. Neither the timing of the spurt, nor the spurt duration or height gain had an influence on the final height. The maturation of the dentition was weekly, or no significantly, correlated with growth in height. The age at menarche revealed significant correlations with all characteristics of the growth spurt except for adolescent increment and adult height.


    1688/2523

    Tytuł oryginału: The effects of menstrual and menopausal factors on bone mineral content in healthy Polish women.
    Autorzy: Szklarska Alicja, Jankowska Ewa, Łopuszańska Monika
    Źródło: Prz. Antropol. 2002: 65 s.43-56, il., tab., bibliogr. s. 54-55, streszcz.
    Sygnatura GBL: 301,512

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie polskie: Celem pracy było: (1) ocena, który czynnik, wiek kalendarzowy czy menopauza, ujawnia bardziej szkodliwy wpływ na stan mineralizacji kośćca (BMC) zdrowych kobiet; (2) oszacowanie wpływu innych czynników (wiek manarche, ilość lat reprodukcji, ilość lat po menopauzie) na redukcję masy kostnej. Materiał stanowiła grupa 928 kobiet (715 przed i 213 po menopauzie), w wieku od 20 do 62 lat, zdrowych, czynnych zawodowo mieszkanek Wrocławia. Gęstość gąbczasta, korowa i całkowita oceniana była na przedramieniu ręki niedominującej metodą pQCT przy użyciu aparatu XCT Stratec 960. Badane kobiety podawały w ankiecie wiek chromologiczny, wiek menarche i wiek menopauzy. Z tych danych obliczpono liczbę lat reprodukcji i liczbę lat po menopauzie. Różnice pomiędzy poszczególnymi grupami testowano za pomocą dwuczynnikowej analizy wariancji ANOVA. Uzyskane wyniki wskazują, że menopauza silniej niż wiek chronologiczny pobniża poziom BMC, w szczególności w części gąbczastej (tab. 1). Dlatego też w dalszej analizie wydzielono 2 grupy kobiet: przed i po menopauzie. Wcześniejsza menarche miała istotny wpływ na BMC jedynie u kobiet przed menopauzą (tab. 2 i 3, rys. 4-6). Wśród kobiet po menopauzie na redukcję masy kostnej silniejszy wpływ miała liczba lat jakie upłynęły od menopauzy niż długość okresu reprodukcyjnego (tab. 4). Należy zauważyć, że wiek kalendarzowy istotnie wpływa na obniżenie masy kostnej tylko wśród kobiet po menopauzie (rys. 1 - 3).

    Streszczenie angielskie: The aims of this study were the following: (1) An evaluation of which factor, aging itself or the occurrence of menopause, revealed a more detrimental effect on bone mineral content (BMC) of fealthy women; (2) An assessment of influence of other factors (the menarcheal age, the total number of reproductive years and the length of the period after menopause) on BMC. Our sample material comprised a group of 928 healthy females (715 pre- and 213 postmenopausal), aged 20 - 62. BMC at the ultra-distal radius was assessed by pQCT. BMC differences between particular groups were tested using a two-way ANOVA. The menopause was related to BMC decline and the impact of menopausal hormonal alternations was much stronger than that of chronological age. Among postmenopausal women, the total number of reproductive years was not an independent predictor of better bone status. In premenopausal women the beneficial effect of earlier menarche on bone tissue is maintained.


    1689/2523

    Tytuł oryginału: Recent trends in stature of 14-year-old boys from Wrocław, Poland.
    Autorzy: Kołodziej Halina, Kozieł Sławomir
    Źródło: Prz. Antropol. 2002: 65 s.57-63, il., tab., bibliogr. s. 62-63, streszcz.
    Sygnatura GBL: 301,512

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie polskie: Porównywano wysokość ciała ponad 1014 chłopców w wieku 14 lat z Wrocławia, badanych w 1997 roku, z grupą 3120 14-latków z Wrocławia badanych w 1987 roku. Średnia wysokość ciała badanych chłopców z Wrocławia zwiększyła się z 163,6 cm w 1987 roku do 165,6 cm w 1997. Oznacza to przyrost przeciętnej wysokości ciała o 2,0 cm (tabela 1). Analiza zmian sekularnych wysokości ciała w obrębie grup społecznych wyodrębnionych na podstawie wykształcenia ojca wykazała, że podobnie jak dziesięć lat wcześniej, w 1997 r. najwyżsi byli chłopcy, których ojcowie mieli wyższe wykształcenie, a najniżsi okazali się synowie ojców z wykształceniem zawodowym i podstawowym. Największy przyrost przeciętnej wysokości ciała (2,8 cm) stwierdzono w badanym okresie w grupie chłopców, których ojcowie mieli wykształcenie średnie, przez co grupa ta bardzo zbliżyła się pod względem wysokości ciała do grupy chłopców, których ojcowie mieli wykształcenie wyższe. W ciągu badanego okresu przeciętna wysokość ciała chłopców, których matki miały wykształcenie wyższe, średnie lub zawodowe wzrosła. Największy wzrost przeciętnej wysokości ciała odnotowano wśród synów matek z wykształceniem średnim, przez co grupa ta bardzo zbliżyła się do grupy chłopców, których matki miały wykształcenie wyższe (tab. 1 i rys. 1). Uzyskane wyniki wskazują zatem, że mamy do czynienia ze zmniejszaniem się różnic pomiędzy niektórymi grupami społecznymi wyodrębnionymi na podstawie wykształcenia rodziców, co prowadzi do pewnej dychotomizacji skali społecznej.

    Streszczenie angielskie: The aim of this study was to investigate the educational group-specific secular trends in stature of 14-year-old boys from Wrocław. The study was based on two cohorts of boys measured in 1987 and 1997. On the basis of mother and father education level divided into three categories, social sub-groups were selected. During the period 1987 - 97 the mean stature of 14-year-old boys has risen from 163.6 cm in 1987 to 165.6 cm in 1997. Growth trends were positive in all sub-groups selected on the basis of father education. The analysis of secular changes in body height within the separated social sub-groups showed that boys whose fathers had a university education were the tallest and boys whose fathers had basic vocational or elementary school education were the shortest. The greatest increment in body height (2.82 cm) took place in the sub-group of boys whose fathers had secondary school education. In all of the sub-groups selected on the basic of mother education the growth trends were positive. The boys from the sub-group where the mother had secondary school education experienced the largest increment in body height during the period 1987 - 97.


    1690/2523

    Tytuł oryginału: Anthropometric craniofacial pattern profiles in microcephaly.
    Autorzy: Abdel-Salam Ghada M. H., Gyenis Gyula, Czeizel Andrew E.
    Źródło: Prz. Antropol. 2002: 65 s.65-74, il., tab., bibliogr. s. 73-74, streszcz.
    Sygnatura GBL: 301,512

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.

    Streszczenie polskie: Celem pracy było: (1) zbadanie proporcji mózgowej i twarzowej części głowy u osób z mikrocefalią i określenie stopnia odchyleń tych proporcji od wartości uznawanych za normalne w populacji oraz (2) zbadanie korelacji między obliczoną pojemnością puszki mozgowej a wskaźnikiem IQ w grupie mikrocefalików. U 60 osobników w wieku 1 - 27 lat z rozpoznaną mikrocefalią, pochodzących z Węgierskiego Rejestru Wad Wrodzonych, zmierzono długość i szerokość głowy, wysokość i szerokość twarzy oraz obwód głowy. Oznaczono również iloraz inteligencji IQ. Z pomiarów obliczono wskaźniki ilorazowe i pojemność puszki mózgowej. Wartość pomiarów znormalizowano na właściwe dla płci i wieku normy węgierskie. Porównań osób z różnymi postaciami mikrocefalii i z danych dla osób zdrowych dokonano metodą profili wartości znormalizowanych z. Stwierdzono, że profile nie różnią się istotnie między podgrupami z mikrocefalią prostą (IMC) i złożoną (MMC) oraz między podgrupami z mikrocefalią pierwotną (PMC) i wtórną (SMC). Wskaźnik wewnętrznej zmienności kształtu głowy ĺz u osób z mikrocefalią (średnia z odchyleń standardowych znormalizowanych pomiarów głowy osobnika) u badanych osób wynosił średnio 4,77. U osób tych nieistotny okazał się również współczynnik korelacji między objętością puszki mózgowej i wskaźnikiem inteligencji IQ.

    Streszczenie angielskie: Craniofacial measurements were taken in 60 cases presenting with microcephaly. The case were classified etiologically and morphologically and the latter was further subclassified. Craniofacial pattern profiles, cranial capacity, and the pattern variability index were calculated and compared with normal Hungarian controls of the same age and sex. In addition, correlation analysis between cranial capacity and IQ was done. Our results show significant similarity of the craniofacial pattern profiles between isolated microcephaly (IMC) and multiple microcephaly (MMC), and between primary microcephaly (PMC) and secondary microcephaly (SMC). The pattern variability index of the microcephalic cases was 4.77. There was no correlation between cranial capacity and IQ in the microcephalic patients.


    1691/2523

    Tytuł oryginału: Comparison of various decalcificators in preparation of DNA from human rib bones.
    Autorzy: Żołędziewska Magdalena, Gronkiewicz Stanisław, Dobosz Tadeusz
    Źródło: Prz. Antropol. 2002: 65 s.75-80, tab., bibliogr. s. 79-80, streszcz.
    Sygnatura GBL: 301,512

    Hasła klasyfikacyjne GBL:
  • prawo
  • genetyka
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy podano przegląd technik preparacji DNA z kości ludzkich (fragmentów żeber pobranych wkrótce po śmierci) ze szczególnym uwzględnieniem etapu jedno- i dwustopniowego odwapniania tkanki kostnej przed wydobyciem z niej materiału genetycznego (tabela 2). Wypróbowano bufory odwapniające stosowane przez różnych autorów (tabela 1) a także odwapniacze własnego pomysłu. Stwierdzono, że ze 100 mg wyżej wymienionego materiału można uzyskać ponad 80 mikrogramów DNA, jednakże dlugość wypreparowanych fragmentów nie przekracza 1000 bp. Najlepszym odwapniaczem okazał się 0.5 M roztwór EDTA. Wypróbowano (tabela 3) także przydatność różnych detergentów, wspomagających działanie odwapniaczy. Najlepsze wyniki osiągnięto przy użyciu soli sodowej siarczanu dodecylu (SDS).

    Streszczenie angielskie: Various calcium-binding buffers and agents in DNA preparation from fresh human rib bones were compared. We showed that the buffer described by Kuntze et al. [1996] yielded the highest quantities of DNA, but the obtained DNA was strongly degraded. The best quality DNA was obtained using two buffers: of H„nni et al. [1994] and of Ivanov et al. [1995]. Among the new calcium-binding agents that were not examined before, the most efficient were Bismuth III Oxide and Na/FeEDTA, and - in two-step decalcification - sodium citrate.


    1692/2523

    Tytuł oryginału: Professor Romuald Sztaba.
    Autorzy: Stoba Czesław, Meissner Fritz, Booss Dieter, Łodziński Kazimierz
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.57-59, il.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca biograficzna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku
  • historia XXI wieku

    Temat osobowy:
  • Sztaba
  • Romuald 1913-2002


    1693/2523

    Tytuł oryginału: Edward Drescher - supporter of conservative treatment in giant omphaloceles.
    Autorzy: Latawiec-Mazurkiewicz Irena, Gazda Piotr, Kwas Artur
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.60-64, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca historyczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: In the nineteen fifties and sixties, before Schuster introduced his method of treating giant omphaloceles, the idea of a conservative approach to this condition was justified. Two options were discussed: surgical treatment with risk of subsequent respiratory-circulatory complications following reduction of the omphalocele contents into the peritoneal cavity (without support of modeern neonatal ventilators and neonatal intensive care facilities), versus conservative treatment. The latter approach did not carry the risk of the above-mentioned sequelae; however, such complications like infection, obstruction or intoxication caused by disinfectant applied to the surface of the omphalocele could occur. Edward Drescher, the Head of the Department of Pediatric Surgery, Pomeranian Academy of Medicine (1974-1977) was a supported of the conservative approach in treatment of giant omphaloceles.


    1694/2523

    Tytuł oryginału: Physeal lesions and growth arrest.
    Autorzy: Okłot Krzysztof, Królicka Jolanta, Kucharski Jacek, Waciuta Andrzej, Kowalczuk Jan, Czech Mirosław
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.65-72, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The authors analyzed growth plate arrest in their own clinical material. There were 69 children with different types of growth plate lesions treated at the Trauma and Orthopedic Department of the District Children's Hospital in Warsaw between 1993-2000. The largest number of patients, 23, had suffered from the septic arthritis. There were also other causes of growth plate lesions, such as trauma, developmental abnormalies, bone tumours, congenital anomalies, iatrogenic lesions, and others. Sixty-one orthropedic procedures were performed. Some patients were reoperated because of recurrence of deformations during growth.


    1695/2523

    Tytuł oryginału: Morgagni hernia in children.
    Autorzy: Porębska Anna
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.73-75, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć żeńska

    Streszczenie angielskie: This report presents our experience in the treatment of Morgagni hernia. All patients were female children aged 3 months, 4, and 11 years. Frontal and lateral chest and abdomen films were the basic imaging examination. Contrast examination of the alimentary tract was performed in one child, and two children underwent ultrasonography. Two children were diagnosed with right-sided hernia and one with bilateral hernia. In one child the hernia sac included the transverse colon, in the second one it encompassed the omentum and transverse colon, whereas in the infant, the small bowel. The children were operated throught a transabdominal apporach. The postoperative recovery was uneventful.


    1696/2523

    Tytuł oryginału: Perioperative pain relief following inguinal herniorrhaphy in children. Caudal versus ilioinguinal and iliohypogarstric nerve blockade.
    Autorzy: Nemeth Eva, Thory K., Machay T., Verebely T., Reusz Gy.
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.76-80, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia
  • anestezjologia
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: We evaluated the efficacy of two routinelly used regional anesthetic techniques, caudal epidural blockade (CEB) and ilioinguinal/iliohypogastric nerve blockade (IIB), in pediatric ambulatory surgeery patients. Forty two children undergoing herniorrhaphy were included in a prospective, randomized, observer-binded study. They received either 0.75 ml/kg (maximum 37.5 mg) caudal bupivacaine 2.5 mg/ml with epinephrine 1 : 200000 (CEB group; n = 25; age 42.4 months [13-78]) or 0.5 ml/kg (maximum 37.5 mg) bupivacaine 2.5 mg/ml with epinephrine 1 : 200000 for ilioinguinal/iliohypogastric nerve (NNb group; n = 17; age 42.4 months [12-94l). Postoperative analgesia was complemented by evaluation of the short-term hearrt rate variability (rMSSD : root-nean square of successive differences). The systolic BP at the end of surgery was found to be lower in the CEB group ((92 ń 2.9 mmHg) as compared wityh the IIB group (105 ń 3.0 mm Hg, p 0.005). During the recovery period both the HR and the systolic BP were lower in the CEB group than in the II B group (HR: CEB group 119 ń 3.7 min.**-1 vs. IIB group 136 ń 5.0 min**-1, p 0.05; systolic BP; CEB group 94 ń 4.9 mm HG vs. IIB group 109 ń 3.1 mmHg, p 0.02). During recovery, rMSSD increased to a higher level in the CEB group (30.8 ń 4.8 msec). than in the group (16.0 ń 3.6 msec, p 0.05). Hemodynamic parameters such as the HR and BP and rMSSD all demonstrated a lowerr sympathetic tone during recovery in CEB patients than in IIB patients.


    1697/2523

    Tytuł oryginału: Assessment of burn wound bacteriology in heat injuries treated with silver sulphadiazine vs. Glycerol-preserved human skin allografts.
    Autorzy: Szmytkowska Krystyna
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.81-84, tab., bibliogr. 11 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • farmacja
  • transplantologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.

    Streszczenie angielskie: The following report compares bacterial populations cultured from wound surfaces and bodily ofices of pediatric burn patients. The study group consisted of 81 children treated with allografts; the control group included 79 children treated with silver sulphadiazine. In our study, the most frequent cause of burn wound contamination was autoinfection. Coagulase-negative Staphylococcus aureus was the predominant pathogen in both groups; it was present in 14 patients of the study group and 21 controls. Streptococcus pyogenes, Pseudomonas aeruginosa and Enterococcus sp. were found in one patient each, Acinetobacter baumani in two children. Analysis of the material colled on the third post-burn day showed no change in bacterial population structure compared with that on admission - in two patients receiving antibiotic treatment a reduction was observed in Staphylococcus growth rate. Bacteriological smears collected on the seventh post-burn day showed an increase in A. baumani growth rate. All other bacteria showed low growth rates. Antibiotic thaerapy was introduced in cases with simultaneous thorat, ear or upper airway infection. Our observation leads to the conclusion that while the degree of bacterial contamination of the burn wound is largely influenced by the bacteriological status of the patient prior to the injury, it is the role of the dressing to prevent infection from other patients, personnel or the patient himself.


    1698/2523

    Tytuł oryginału: Gas embolism during irrigation of an infected open fracture of the forearm by hydrogen peroxyde.
    Autorzy: Al Faour A., Vrsansky P., Dabbagh H., Pellerin M., Vrsansky D.
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.85-87, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • pulmonologia
  • toksykologia
  • traumatologia i ortopedia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: Hydrogen peroxide (H202) is widely used in traumatology as an irrigation fluid in fight against an anaerobic infection on infected and dirt wounds. Their observation corresponds with several similar cases, even with patient's death, referred in the literature. Therefore it is important to call clinicians'attention that H2O2 is not perfectly safe product.


    1699/2523

    Tytuł oryginału: Double duodenal obstruction: annular pancreas combined with distal congenital stenosis.
    Autorzy: Papandreou E., Soutis M., Baltogiannis N., Christopoulos-Geroulanos G., Keramidas D.
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.88-90, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska

    Streszczenie angielskie: Congenital duodenal obstruction (CD0) in combination with more distal duodenal obstructions is extremely rare. The latter may be missed if not looked for conscientiously during the operation. This is a report of our experience with two newborn babies, who presented with atresia combined with annulat pancreas and a second distal duodenal obstruction. Material and methods: During the last 15 years (1986-1999) 53 children were opertaed upon for CDO, of whom two had a double duodenal obstruction. They presented with non-bilious vomiting and the plain film of the abdomen showed the typical "double -bouble". Operative findings: a) annular pancreas causing complete pobstruction of the second part of the duodenum, b) distension or dilatation of the duodenum distal to this obstruction due to an additional congenital stenosis. A diamond shaped duodeno-duodenal anastomisis was carried out to relieve the proximal obstruction and a Heinecke-Milulicz plasty was used to relieve the distal stenosis. Results: The postoperative course was uneventful and feedings could be started on the 20th postoperative day. An upper gastrointestinal series on the 30th day showed free passage of the contrast material.


    1700/2523

    Tytuł oryginału: Diagnostic and therapeutic difficulties in the curraino triad.
    Autorzy: Kudela Grzegorz, Bohosiewicz Janusz
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.91-93, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • płeć męska

    Streszczenie angielskie: We report a case of Currarino triad that was erroneously diagnosed as Hirschsprung disease. The correct diagnosis was made during the operation, which consisted of the Duhamel-Ikeda pullthrough procedure and excision of presaacral mass. After the operation massive leakage of cerebrospinal fluid throught the catheter left in the presacral region, high temperature and nuchal rigidity were found. The leakage ceased after three weeks of conservative treatment. Feacal incontinence was noted after surgical treatment. Rectal examination revealed weak sphincters. At 4-year follow-up the child is socially continent thanks to daily enemas. THe Currarino triad is a unique malformation that should be considered in constipation diagnostics. Missing the malformation can cause incorrect treatment, which can be life threatening for the child.


    1701/2523

    Tytuł oryginału: Acute hemorrhagic necrotizing pancreatitis caused by cholelithiasis.
    Autorzy: Kamiński Andrzej, Drewniak Tomasz, Broniszczak Dorota, Kaliciński Piotr, Kluge Przemysław, Teisseyre Joanna, Polnik Dariusz
    Źródło: Surg. Childh. Int. 2002: 10 (2) s.94-98, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,040

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Cholelithiasis is an uncommon disease in children. Acute necrotizing pancreatitis is the mpost serious complication of this disease. During the last year, two female patients aged 12 and 14 years were treated at our center for acute necrotizing pancreatitis complicating cholelithiasis. More than 90 p.c. of their pancreatic glands were necrotic. THe moreseverely ill patients underwent multi-staged surgery, whereass tha patient in relatively better condition was operated on in one stage. The surgery entailed resection of necrotic tissue, cholecystectomy and reconstruction of the outflow of bile and pancreatic juice with a double Roux-Y loop. The postoperative course was complicated by biliary and pancreatic fistulae.


    1702/2523

    Tytuł oryginału: Differential expression intensity of CD58 and HLA-DR on myeloblasts in acute myeloid leukaemia (AML).
    Autorzy: Woźniak Jolanta, Kopeć-Szlęzak Joanna
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.75-79, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The CD58 (LFA-3) and HLA-DR expression intensity on leukemic cells of 53 adult patients with AML M1 and M2 was determined. Also the relation between these expressins and the achievement remission in patients was searched. Two quantitative flow cytometry methods of the expression intensity analysis of CD58 and HLA-DR antigens were performed. The analysis indicated that myeloblasts at diagnosis of patients with post chemotherapy remission (CR+) showed higher of both CD58 and HLA-DR intensity expression as compared to patients with no remission (CR-) despite intensive chemotherapy (p 0.01). Our results indicated that high expression intensity of studied molecules on leukemic myeloblasts myeloblasts might be benificial factor anti-leukemic activity of lymphocytes T and NK cell. Additionally, the level of expression CD58 and HLA-DR may be useful element in the AML remission prognosis.


    1703/2523

    Tytuł oryginału: The estimation of selected auto-immune parameters in patients with pre-eclampsia.
    Autorzy: Darmochwal-Kolarz Dorota, Leszczyńska-Gorzelak Bożena, Roliński Jacek, Oleszczuk Jan
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.80-83, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Background: The aim of the study was to investigate the population of B CD 19+ cells and autoreactive B-1 CD19+5+ lymphocytes in peripheral blood and these presence of anti-cardiolipin antibodies in the serum of patients with pre-eclampsia and healthly pregnant women. Materials and methods: 40 patients with pre-eclampsia and 40 healthly pregnant women were included in the study. The expresion of surface molecules were estimated using the two-color flow cytometric method. The total concentrations of class IgG, IgM and IgA anati-cardiolipin antibodies were measured with the use of the semi-quantitaive ELISA immunenzymatic method. Resuklts: The percentage of B CD 19+ cells in the group of patients with pre-eclampsia did not differ in comparison with healthly, pregnant women. The percentage of B-1 CD19+5+ lymphocytes, which are responsible for the production of autoantobodies, did not exceed 1.5 p.c. in both studied groups. The negative value of anti-cardiolipin antibodies was present in 70.0 p.c. of patients with pre-clampsia and in 75.0 p.c. of healthly women 17.5 p.c. of patients from the study group and 15.0 p.c. of healthly pregnant women had the borderline value of ACA. The positive value of ACA was presented in 12.5 p.c. of patients with pre-eclampsia and 10.0 p.c. from the control group. Conclusions: The results obtained suggested that anti-cardiolipin antibodies are not the leading cause of pre-eclampsia.


    1704/2523

    Tytuł oryginału: Cytokine production in major depression. The role of proinflammatory cytokines and Th1/Th2 dysfunction.
    Autorzy: Kamińska Teresa, Marmurowska-Michałowska Halina, Dubas-Ślemp Halina, Wysocka Alicja, Kandefer-Szerszeń Martyna
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.84-89, tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Over the years a body of evidence has been accumulated suggesting that major depression is associated with dysfunction of immune reactions. Depressed patients exhibiting dysregulation of HPA-axis and excessive production of glucocorticoids have at the same time enchanced proinflammatory response but supressed lymphocyte proliferative reactivity and delayed-type hypersensitivity skin response. The goal of this study was to investigate whether depression is associated with impaired production of several cytokines which, as it is known, are mainly the products of monocytes/macrophages such as IL-1á, IL-6, INF-ŕ, TNF-ŕ and also T lymphocytes subtypes Th1/Th2 such as IL-2, IFN-ç and IL-4, IL-10 respectively. We studied 29 hospitalized patients who met the criteria for majpor depressive disorders and 30 healthly control subjects, matched for age and gender. Depressed patients had elevated serum level of proinflammatory cytokine such as IL-Iá. Significantly increased IL-1á level in vivo was connected with a decrease of its production after stimulation in vivo with a strong inducer (LPS), however these differences were not statistically significant. Moreover, we also detected a defect in IFN-ŕ in vivo release ansd in vitro synthesis, which might influence the cytokines production by Th1/Th2 lymphocytes, observed as significant decrease in IL-10 serum concentrations and/or decrease in IL-2 production in blood cell cultures. The role of the observed overproduction of proinflammatory cytokines and the imbalance in TH1/Th2 cytokines in depression has been discussed.


    1705/2523

    Tytuł oryginału: Soluble platelet endothelial cell adhesion molecule-1 in ischemic stroke patients is related to the extent of early brain damage.
    Autorzy: Zaremba Jarosław, Losy Jacek
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.90-96, il., bibliogr. 54 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Inflammatory response following acute cerebral ischaemia exacerbates damage and enlarges infarct extent. The role of adhesion molecules mediating attachment and migration cells within the ischemic cerebrovascular region seems to be critical in the development of stroke-induced inflammatory reaction. Platelet endothelial cell adhesion molecule-1 (PECAM-1) present at cell to cell junction is reguired for transendothelial migration of leukocyters. We have recently demonstrated that ischaemic stroke patients displayed increased soluble PECAM-1 isoform (sPECAM-1) levels in serum and cerebrospinal fluid (CSF) within 24 after the disease onset. The aims of the present study performed in the same group of 23 ischaemic stroke patients were to investigate the relationship between the levels of sPECAM-1 and the extent of early brain damage as well as stroke severity and its outcome. We have compared sPECAM-1 levels in serum and CSF samples obtained from the patients within 24 h of first-ever completet hemispheric ischaemic stroke with the volume of anatomically relevant rarly computed tomography (CT) of the brain hypodense areas as well as the neurological stroke severity estimated according to the Scandinavian Stroke Scale (SSS) scores and the functional disability assessed with the Barthel Index (BI) scores. The significant correlation between sPECAM-1 levels both in sera and CSF stroke subjects and the volume of early brain CT hypodense areas aswell as both the SSS and the BI scores determined within 24 h of stroke and at 2nd week after...


    1706/2523

    Tytuł oryginału: Analysis of HLA frequencies in donor population of Unrelated Bone Marrow Donor and Cord Blood Registry of Institute of Haematology and Blood Transfusion.
    Autorzy: Nowak Jacek, Gronkowska Anna, Brojer Ewa
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.97-115, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • genetyka
  • hematologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The HLA alleles and haplotypes frequencies of Polish population are helpful in the routine work of HLA laboratory and in searching of underlated bone marrow donors for Polish patients. HLA I class typing was performed by standard serological method in 2580 potential donors from Poland, and HLA DRB1 DNA typing by PCR-SSP or PCR-SSOP at low resolution level in 386 donors chosen by chance from the said population. Allelic and haplotypic (2 or 3 loci haplotype) gene frequencies were estimated by iterative maximum likelihood gene counting method suplemented by expectation maximization and Hardy-Weinberg equilibrium algorithm using ML-EM-HW v. 5.2 software elaborated in our Institute. The resolution of used methods was: 24 specifies of HLA-A, 46 HLA-B, 11 HLA-Cw, and 17 HLA*DRBI. There was a different portion of HLA "blank" in each locus. Allele gene frequencies were comparable with other Central Europe population frequencies. Estimated and observed antigen phenotypic frequencies were very similar. Fit to Hardy-Weinberg equilibrium was tested by Xý test foreach locus separately and was good (p=1.0000). The highest positive linkage was found in following two-locus haplotypes: A*01-B*08 (GF 0.0739, delta 0.0613, p 0.0001), A*03-B*07 (GF 0.0504, delta 0.0333, p 0.0001) and A*25-B*18 (GF 0.0334, delta 0.0288, p 0.0001). Very high, but negative linkage was found for A*02-B*08 (GF 0,0075, delta-0.0215, p 0.0001) and A*01-B*18 (GF 0.0010, delta-0.0095, p 0.0001) two locus halotypes. Sixteen HLA-A-B-DRBI there-locus haplotypes showed gene frequency...


    1707/2523

    Tytuł oryginału: Expression of adhesion molecules and chemiluminescence of peripheral blood neutrophils in children with ulcerative colitis.
    Autorzy: Kisiel Anna, Grzybowska Krystyna, Zeman Krzysztof, Fornalczyk-Wachowska Ewa, Pietruszyński Robert, Płaneta-Małecka Izabela
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.116-122, il., bibliogr. 40 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology. In recent years neutrophils have been throughly studied as the cells directly responsible for tissue damages. The aim of the study was to determine whether in ulcerative colitis neutrophils were activated only in inflammatory focus or perhaps they manifest activation in peripheral blood before leaving circulation. The study comprised 30 children with ulcerative colitis aged between 8-18 years. In all subjects the chemiluminescence of the resting and the FMLP and PMA activated neutrophils was determined, as well as the CD11b, CD18, CD62L and CD16 receptor expression on the resisting neutrophils, and CD11b, and CD62L on the FMLP stimulated neutrophils. The study was conducted in severe disease activity before treatment and after 2 months of remission. Sixteen children with constipation cases formed the control group. In all assessed children with ulcerative colitis there were determined higher values of neutrophil chemiluminescence, both resisting and stimulated in comparison with controls. The CD11b receptor expression in children with severe and moderate disease activities was significant higher, especially on the resting neutrophils, and the CD62L expression was significantly lower in comparison with controls. The test results were normalized during remission.


    1708/2523

    Tytuł oryginału: The influence of genital mycoplasmas on human placental mast cells.
    Autorzy: Wasiela Małgorzata, Brzezińska-Błaszczyk Ewa
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (3) s.123-128, il., bibliogr. 51 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • ginekologia i położnictwo
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The aim of this study was to establish whether genital mycoplasma could active in vivo human placental mast cells to mediator release. We have used temperature-killed Mycoplasma hominis (7 strains), Ureaplasma urealyticum (12 strains) and, for comparison, 5 strains of normal vaginal flora (Lactobacillus fermentum, L.jenseni, L.acidophilus (2 strains), Bifidobacterium adolescents) isolated from cervical canal of pregnant women. We have noticed that that M.homonis- and U.urealyticum-induced histamine release from placental mast cells were very high (up to 41.2 p.c. and 50.2 p.c. respectively). At the same experimental conditions the stimulation of placental mast cells with strains of normal vaginal flora resulted in insignificant histamine secretion (0.4 - 3.8 p.c.). The conclusions were that genital mycoplasma present in reproductive tract can activated placental mast cells to mediator release. Thus it can be speculated that these strains of bacteria may influence the course of pregnancy via interaction with placental mast cells.


    1709/2523

    Tytuł oryginału: Thyroid-associated ophthalmopathy - diagnostics and treatment.
    Tytuł polski: Oftalmopatia Gravesa - diagnostyka i leczenie.
    Autorzy: Lewiński Andrzej, Makarewicz Jacek, Adamczewski Zbigniew, Knapska-Kucharska Małgorzata, Karwowska Anzelmina
    Źródło: Endokrynol. Pol. 2002: 53 (4) supl. 1: Konferencja naukowo-szkoleniowa "Orbitopatia tarczycowa" s.33-46, tab., bibliogr. 67 poz., streszcz. - Konferencja naukowo-szkoleniowa pt. Orbitopatia tarczycowa Poznań 14-15.12. 2001
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • okulistyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W obecnej pracy przedstawiono w zarysie elementy etiopatogenezy oftalmopatii Gravesa (thyroid-associated ophthalmopathy - TAO), diagnostyki tej choroby oraz omówiono szczegółowo zasady doboru najwłaściwszych metod leczenia w zależności od aktywności oraz stopnia nasilenia objawów choroby. Szczególną uwagę zwrócono na te badania diagnostyczne, które należy zastosować w celu właściwej oceny aktywności oftalmopatii.

    Streszczenie angielskie: In this paper, elements of pathogenesis of thyroid-associated opthalmopathy (TAO) have been outlined. Diagnostcs of this disease and the rules of selection of the most appropriate therapy have been discussed in detail with regards to the activity and the degreeof severity of disease course. The diagnostic examinations, which should be applied for a proper assessment of ophthalmopathy activity, have been discussed with particular attention.


    1710/2523

    Tytuł oryginału: Real-time 3D ultrasound imaging using laser-induced breakdown.
    Autorzy: Yasumuro Yoshihiro, Oshiro Osamu, Chihara Kunihiro, Doi Motonori, Sugiura Tadao, Kawada Satoshi
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.3-16, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca techniczna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In this paper we propose a new framework of ultrasonic (US) three-dimensional (3D) imaging, introducing laser-induced breakdown (LIB) as an acoustic source. LIB is a phenomenon in which substances transformed to plasma by a pulsed laser beam. LIB exposively emits a variety of energies such as heat, light and sound that also includes pulsed ultrasound. Emitted US waves have suitable characteristics for instantenous US imaging in terms of low directively to enable a wide view and sharply pulsed waves to enhance the resolution. Utilizing these characteristics, we attempt to apply the synthetic aperture method for frontal 3D imaging in a real-time process. Experimental results show that even sparsely arrayed sensors allow a wider frontal view than that can be achieved in the case using existing transducer devices.


    1711/2523

    Tytuł oryginału: Automatic understanding of medical images - new achievements in syntactic analysis of selected medical images.
    Autorzy: Tadeusiewicz Ryszard, Ogiela Marek R.
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.17-29, il., bibliogr. 15 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In the paper we try to solve very difficult problem connected with the advances in medical imaging technology: how to replace the goal of image recognition by image understanding. The problem under consideration is crucial one for all applications of information technology in automated systems devoted both for automatic medical diagnosis and for successful searching in medical databases distributed throughout the world. The key problem analysis is how to model processes of image understanding by physician. We develop new tool for intelligent perception of differences between images of normal organs and pathological cases, instead of simple image recognition. We also presented how the same method can be used for searching of multimedial medical information in the respective databases. Such indexing approach enables an intelligent selection of interested case of illness based on visual queries.


    1712/2523

    Tytuł oryginału: Physical aspects of selected medical diagnosis methods using radiation.
    Autorzy: Wasilewska-Radwańska Marta, Jung Aleksandra, Kopański Zbigniew, Hac Agnieszka
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.31-40, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Radioisotope technique allows noninvasive medical diagnosis such as diagnostication of Helicobacter pylori (H. pylori) infection by using urea labelled with C-14 and intraoperative control of sentinel node in breath cancer with use of nanocoloid labelled with Tc-99m. The knowledge of radiotracer transport and internal radiation hazard enable to improve medical diagnosis methods. The urea breath test (UBT) results have been used to apply compartmental modelling for determinating severity and localisation of the Helicobacter pylori infection. The water imaging phantom of breast have been elaborated to prepare the application of a hand-held gamma probe Modelo-2 in an intraoperative control of sentinel node in breath cancer (RIGS - RadioImmunoguided Surgery).


    1713/2523

    Tytuł oryginału: In vitro evaluating system for prosthetic heart valves in a case of the Jyros valve.
    Autorzy: Fujimoto T., Tsutsumi Y., Shiraishi Y., Iwasaki K., Yoshida M., Umezu M., Begg J., Woodard J.
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.41-46, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • praca techniczna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The Jyros valve has unique hydrodynamic characteristics comparing with other types of valves. In this study, precise hydrodynamic characteristcs of the valve were examined uisng a mock circulatory system, which we have developed. Further, the influence of leaflet rotation in the Jyros on hemolysis was evaluated. As a result, the valve rotation is shown to reduce flow resistance under the ratational flow condition which was produced by a spiral vortex pump. However, hemolysis was not revealed to be reduced by the Jyros.


    1714/2523

    Tytuł oryginału: Left ventricle simulator for surgeons support.
    Autorzy: Umezu Mitsuo, Arita Makoto, Iwasaki Kiyotaka, Shiraishi Yasuyuki, Tono Sumihiro, Uchida Koji
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.47-53, il., bibliogr. 2 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: The authors have been developing various types of mock circulatory systems to evaluate a performance of artificial organs. Among several attempts, it was indicated that a stimulation of the mitral valve region was very difficult due to a complicated shape and movement of the valve. In this paper a new trial to install a porcine valve into the mock circulatory systemis introduced. A fresh porcine valve with papillary muscles and chordae was fixed into the mitral position of the modified Windkessel-type mock circulatory system. To allow direct 3-D observation of the mitral annulus, a digital video camera and a laser displacement sensor were employed. A circulation was generated by a pneumatically-driven artificial ventricle. When a normal circulatory condition (pump rate: 70BPM, Flow: 3L/min) was selected, similar opening and closing motion to the natural mitral valve could be reproduced. Moreover, a diseases condition was made by shifting a position of papillary muscles. After this procedure, an abnormal movement, such as significant leakage, could also be reproduced.


    1715/2523

    Tytuł oryginału: Measurement of thermal properties of the skin.
    Autorzy: Togawa Tatsuo, Otsuka Kimio, Hassan Moinuddin
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.55-68, il., bibliogr. 19 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The skin is the boundary between the body and its thermal environment, and heat dissipation from the body depends on the thermal properties of the skin such as thermal conductivity and specific heat as well as emissivity when radiation heat transfer is involved. Such parameters can vary with physiological conditions, especially, thermal conductivity of the skin depends largely on the blood perfusion, and thus in vivo measurement is required. The authors have developed a method of non-contact measurement of emissively and thermal inertia that is defined as square root of the product of thermal conductivity, density and specific heat. The principle of this method is based on measurement at a transient when a constant heat load is applied abruptly to the skin surface by changing the ambient radiation temperature in step-wise fashion. Emissivity and thermal inertia can be determined from the change in radiation from the skin surface at the transient and the slope of the gradual change of the skin surface temperature. By this principle, imaging of thermal parameters was realized. While accurate measurement of small surface temperature change is required, it was shown that high precision thermography systems could be used for this purpose, and we obtained thermal parameters of the skin under normal and suppressed or enhanced blood perfusion. A convenient calibration method was also proposed in which effective ambient radiation temperature can be computed from simultaneously-measured apparent temperatures of two test plates maintained at different temperatures and having...


    1716/2523

    Tytuł oryginału: Impedance methods for tissue characterization.
    Autorzy: Pałko Tadeusz
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.69-77, il., bibliogr. 7 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: The spectral characteristics of electroimpedance of chosen tissues were studied. The results of the experimental and medical study show that the complex impedance as a function of frequency differs for normal and abnormal tissue with chronic circulation disturbances (ischemia). The presented methods are useful and easy for experimental and medical application.


    1717/2523

    Tytuł oryginału: Powers and limitations of noninvasive measurements implemented in pulse oximetry.
    Autorzy: Cysewska-Sobusiak Anna
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.79-96, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The subject of the paper is devoted to pulse oximetry which is one of the most modern diagnostic technique in the field of noninvasive biomedical measurements. A brief review of principles and status of pulse oximetry is presented. The impressive advantages of this diagnostic technique as well as serious problems still connected with reliability of instruments indications are discussed. Tendency to development and major directions in future of pulse oximetry are outlined. On the background of data reported in the literature, the author of this paper describes results collected by her during comparative studies. In these studies, well-known commercial pulse oximeters and a specially designed measuring system, which allows to control components of optical signals acquired from living tissues and to trace sources of errors, were used.


    1718/2523

    Tytuł oryginału: Impedance pharyngography for diagnosis of swallowing disorders.
    Autorzy: Yamamoto Yoshitake, Nakamura Takao, Kusuhara Toshimasa, Mori Keiko
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.97-103, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Swallowing disorders are a serious problem occurring in association with cerebrovascular disorder, nerve or muscle disease, laryngeal or esophageal disease, or advanced age. Unfortunately, it is difficult to evaluate swallowing disorders quantitatively. For this reason, we previously proposed a new method, impedance pharyngography (IPG), for evaluating swallowing disorders noninvasively by measuring neck electrical impedance during swallowing. In this study, the efficacy of this method was tested in a cohort of patients with IPG and healthy controls. The change of neck electrical impedance in the pharyngeal phase is mainly caused by the changes in the equivalent cross-sectional area of the near epiglottis. In addition, the increase in equivalent cross-sectional area due to raising of the larynx caused a decrease in neck electrical impedance in the pharyngeal phase. In the case of healthy subjects, IPG results were highly reproducible, and the patterns were simple and similar. In subjects with advanced age, IPG are delayed-action, slowly changing and less reproducible, and showed various patterns among the subjects. In subjects with swallowing disorders IPG results were less reproducible and showed irregular variable patterns. We therefore conclude that the IPG pattern can be used effectively as a simple index of swallowing activity.


    1719/2523

    Tytuł oryginału: New aspects of endoscopic medical imaging and metrology.
    Autorzy: Podbielska Halina
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.105-113, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Endoscopic inspection is widely used in contemporary medicine as a diagnostic tool. Recent developments show also the capabilities of this technology for some highly specialized therapeutic procedures. Although endoscopy is known as an imaging device for intractivity inspection, it doesn't exceed its role as only two dimensional display. This paper explains how to overcome this limitation be exploting for optical techniques as holography or moire projection, what can result not only in three dimensional imaging but in measurements, as well. The potential role of new technique called virtually endoscopy is discussed, as well.


    1720/2523

    Tytuł oryginału: Lung mechanics measurement independent on ventilatory treatment.
    Autorzy: Darowski Marek, Kozarski Maciej
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.115-121, il., bibliogr. 8 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A new methods of lungs mechanics calculation has been developed, which is independent on the method of ventillatory support and may be used automatically during long-term treatment. Lungs compliance assessment is based on the periodical measurements of airway pressure during expiration. Airways resistance is calculated from expiratory time constant. The results of preliminary, model studies showed that proposed method has a clinically acceptable accurracy and can be performed by a separate instrument, independent on a type of the respirator used.


    1721/2523

    Tytuł oryginału: Remote health monitoring system for the elderly living alone.
    Autorzy: Ohta Shigeru, Shinagawa Yoshimitsu, Tanikawa Tomohiro, Nakamoto Hiroshi
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.123-134, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca techniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.

    Streszczenie angielskie: We have recently developed a health monitoring system for the elderly living alone. We monitored their in-house movements without restricting. We placed pyroelectric infrared sensors in each room of their houses so that monitoring will last longer easily. The secondary purpose of this system is to reduce anxiety of both the elderly and their family members living separately. Subjects of either sex were four inall an in their eighties. Continuous monitoring was performed for 40 months. We found that each one had his/her specific pattern of in-house movements. Therefore, we were able to estimate their health condition by checking the staying periods at specific rooms such as a lavatory or amount of exercise comparing with the previous data statistically. If there is an abnormal result after analysis, we have to inform the family of the incident. Final decision should be made by his/her family, not by automatically relying on the computer software. After inquiring with the subject or his/her neighbours by telephone, family members amy call an ambulance, if necessary.


    1722/2523

    Tytuł oryginału: Modeling of light propagation in the adult head for optical brain function measurement.
    Autorzy: Okada Eiji
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.135-147, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Near infrared (NIR) spectroscopy and imaging are now established techniques for measurements of change in oxygenation nad haemo-dynamics within the brain. However, scattering of the light in biological tissue causes ambiguity in the spatial sensitivity profiles and the partial optical path length in the brain. The light propagation in the adult head model of which optical properties are chosen from the reported data of in vitro experiments is validated by time-resolved measurements of the human foreheads. The apparent optical properties estimated by a least squares fit of the diffusion model to the temporal point spread function for the adult head model agree with the experimental results. The heterogeneity of the head scarcely affects the total optical parth length. However the partial optical path length in the brain and the spatial sensitivity profiles which can not be directly obtained by experiment are considerably affected by the heterogeneity of tissue, especially the presence of low scattering subarachnoid space surrounding the brain.


    1723/2523

    Tytuł oryginału: Sol-gels microoptics for biomedical and environmental measurements.
    Autorzy: Podbielska Halina
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.149-159, il., bibliogr. 30 poz.
    Sygnatura GBL: 306,224

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The advantages of sol-gel biomaterials as host matrices for various dopants are pointed out. The role of optode as a transducer of external signal to the detecting units is discussed in this light, explaining the term of an integrated sensing system. Various sensors with bulk or film sol-gel optodes are presented with a special emphasis on oxygen and urea sensors. The advantages of sol-gel microsensors are discussed, as well.


    1724/2523

    Tytuł oryginału: Izmenchivost mitokhondrialnojj DNK v populaciakh russkovo naselenia Stavropolskovo kraja, Orlovskojj i Saratovskojj oblastejj.
    Tytuł angielski: Mitochondrial DNA variation in Russian populations of Stavropol Krai, Oreal and Saratov Oblasts.
    Autorzy: Malyarchuk B. A., Derenko M. V., Grzybowski T., Czarny J., Miścicka-Śliwka D[anuta], Denisova G. A., Kostyunina E. A.
    Źródło: Genetika 2002: 38 (11) s.1532-1538, tab., bibliogr. 29 poz., sum.
    Sygnatura GBL: 304,994

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Mitochondrial DNA (mtDNA) polymorphism was examined in three Russian populations from the European part of Russia (Stavropol krai, Oreel oblast, and Saratov oblast). This analysis showed that mitochondrial gene pool of Russians was represented by the mtDNA types belonging to haplogroups H, V, HV*, J, T, U, K, I, W and X. A mongoloid admixture (1.5 p.c.) was revealed in the form of mtDNA types of macrophaplogroup M. Comparative analysis of the mtDNA haplogroup frequency distribution patterns in six Russian populations from the European part of Russia indicated the absence of substantial genetic differences between them. However, in Russian populations from the southerm and central region the frequency of haplogroup V (average frequency 8 p.c.) was higher than in the populations from more northern regions. Based on the data on mtDNA HVS1 sequence variation, it was shown that the diversity of haplogroup V in Russians (h = 0.72) corresponded to the highest h values observed in Europe. The reasons for genetic differention of the Russian population (historical, ecological, and adaptative) are discussed.


    1725/2523

    Tytuł oryginału: Cytokines in the subretinal fluid of patients with rhegmatogenous retinal detachment.
    Autorzy: Mrugacz Małgorzata, Bakunowicz-Łazarczyk Alina, Moniuszko Tadeusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.45-48, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • okulistyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study was to evaluate the presence of IL-8, IL-10, IL-13, TNF-alpha and IFN-gamma in subretinal fluid of patients with rhegmatogenous retinal detachment. We studied 46 patients operated on retinal detachment. The presence of cytokines was evaluated using immunoenzymatic assay. IL-8, IL-10, IL-13, TNF-alfa and IFN-gamma were found in all subretinal fluid samples. The presence of cytokines in the subretinal fluid suggest their significant involvement in the pathogenesis of rhegmatogenous retinal detachment, especially that complicated by vitreoretinal proliferation (PVR).


    1726/2523

    Tytuł oryginału: Angiocentric lymphoma - its differentiation with the metastatic lung tumours.
    Autorzy: Michnar Marek, Krawczyk Paweł, Rojowski Andrzej, Milanowski Janusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.49-52, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Angiocentric T-cell lymphoma (described by Liebow as lymphomatoid granulomatosis), which typically involves nose and upper respiratory system, is mostly a multisystemic disease. We report a 27-year-old patient with multiple lesions in both lungs in chest X-ray and CT images resembling the metastatic tumour of the lung. The immunophenotype of 74.5 p.c. of T-lymphocytes from BALF was CD3+, CD4+, CD8+, CD45RO+, CD56-, and CD4/CD8 ratio had a value of 0.26. The diagnosis of angiocentric lymphoma in this patient was confirmed by a histopatological analysis of the material from thoracotomy. The patient was treated with aggressive, multidrug chemotherapy, but he died 3 months after the beginning of the disease with the symptoms of the DIC syndrome and respiratory insufficiency.


    1727/2523

    Tytuł oryginału: HLA DRB1 alleles in HCV RNA positive patients with and without anti-HCV antibodies: relationship with the outcome of infections.
    Autorzy: Brojer Ewa, Kryczka Wiesław, Kalińska Aleksandra, Medyńska Joanna, Żupańska Barbara
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.53-57, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In some individuals infected with HCV, the anti-HCV is not detectable and HCV RNA is the only marker of the infection. Since the formation of certain antibodies is MHC restricted, we evaluated whether there are differences in the HLA DRB1 allele frequency between anti-HCV negative and positive hepatitis patients, and whether the DRB1 frequency difers between patients with self-limited and chronic infection. Material: 167 HCVRNA positive (37 anti-HCV negative to end of follow-up) patients, including 42 with acute hepatitis and 125 chronic hepatitis patients; control group of 286 healthy individuals. After the follow-up for at leats 30 months the patients were divided into 2 groups: those with self-limited and those with chronic hepatitis. Other reasons of hepatitis and obvious immune defects were excluded. Methods: HCV RNA by RT PCR, antiHCV by the third generation EIA; DRB1 by INNOLiPA DRB1. Results: We found no difference in the frequency of DRB1 alleles between the healthy individuals and HCV infected patients nor between the anti-HCV negative and positive patients. However, the frequency of DRB1*15 and DRB1*11 observed in the patients with self-limited infection was significantly higher than that in the patients with chronic infection. This difference was independent of anti-HCV delectability.


    1728/2523

    Tytuł oryginału: Humoral and cellular response in children with past pertussis infection.
    Autorzy: Przybyszewski Michał, Grzybowska Krystyna, Banasik Małgorzata, Płaneta-Małecka Izabela, Zeman Krzysztof
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.58-62, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In the 90-ies there has been observed an increased pertussis incidence rate, despite the high percentage of vaccination among the children's population, between 86 p.c. and 99 p.c., depending on the region. Up till now pertussis had been diagnosed mainly in infants and children aged between 2 and 5 but during the last decade the disease was diagnosed mainly in children above 5 years of age who underwent a full cycle of pertussis vaccination. In searching for the reasons of that epidemiologic situation there have been suggested changes in bacteria antigenicity, the phenomenon of the postvaccine immunity decrease, unjustified vaccination exemptions and a possibility of immunological system disorders. The study assess, selected parameters of cellular and humoral response together with the level of postvaccine antibodies resulting after immunization with specific vaccines in children with past pertussis.


    1729/2523

    Tytuł oryginału: Reactivity of human serum transferrin with two mannose-binding lectins: LCA and ConA.
    Autorzy: Sobiesiak Małgorzata
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.63-68, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Acute phase response is a systemic response to mechanical injuries, traumas or bacterial inflammations. Acute phase proteins (apps) play an important role in this non-specific reaction. These serum N-glycoproteins physiologically occur in few variants what is called a microheterogeneity. During acute N-glycoproteins physiologically occur in few variants what is called a microheterogeneity. During acute phase response both concentrations and percentage contents of individual variants are changed. In this report we tried to analyse transferrin microheterogeneity using two lectins: ConcanavalinA (ConA), a lectin from Canavalia ensiformis and for the very first time Lens culinaris agglutinin (LCA). Both lectins have the same specificity for D-glucosyl and D-mannosyl residues. We compared Tf microheterogeneity in three groups of sera: healthy controls and of patients with acute and chronic conditions. To estimate the microheterogeneity of the transferrrin the affinity immunoelectrophoresis according to Bog-Hansen was used. To measure the total transferrin concentration the rocket immunoelectrophoresis acc. to Laurell was used. In a crossed affinoimmunoelectrophoresis with ConA, Tf in healthy sera of patients with traumas and chronic inflammations create four variants: T1, T2, T3, T4 (from the fastest to the most retarded one). The percentage contents in reaction with controls was T1 = 4 p.c., T2 = 9 p.c., T3 = 82 p.c., T4 = 4 p.c. In a crossed affinoimmunoelectrophoresis with LCA, Tf in healthy sera of patients with traumas create three glycoforms: ...


    1730/2523

    Tytuł oryginału: Taurine chloramine - its role in immunity and new perspectives for clinical use.
    Autorzy: Koprowski Marek, Marcinkiewicz Janusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.69-74, il., bibliogr. 47 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In recent years tauring chloramine raised considerable interest as a part of the immune system. Regarded at first as a simple end-product of HOCl metabolism during further studies it revealed oxidative, bactericidal and immunomodulatory properties. Today there is little doubt as to its complex role in mechanisms of both innate and acquired immunity. This review is an attempt to summarize our knowledge about its properties and role in the immune system.


    1731/2523

    Tytuł oryginału: Prognostic value of the time interval between surgery and adjuvant radiotherapy in patients treated for early stage invasive cervical cancer.
    Tytuł polski: Znaczenie rokownicze czasu rozpoczęcia napromieniania pooperacyjnego w leczeniu chorych na raka szyjki macicy we wczesnym stopniu klinicznego zaawansowania.
    Autorzy: Krynicki Ryszard, Panek Grzegorz, Wierzba Waldemar, Jońska Joanna, Lindner Bogusław, Gawrychowski Krzysztof, Bidziński Mariusz
    Źródło: Nowotwory 2002: 52 (6) s.483-486, il., tab., bibliogr. 19 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: Wstęp. Ocena znaczenia prognostycznego czasu, jaki upłynął od operacji chorych na inwazyjnego raka szyki macicy do rozpoczęcia uzupełniającego napromieniania. Materiał i metoda. Przedmiotem analizy retrospektywnej była grupa 96 chorych, pierwotnie operowanych z powodu raka szyjki macicy w stopniu klinicznego zaawansowania Ib i napromienianych uzupełniająco w przypadku obecności niekorzystnych rokowniczo czynników, takich jak: przerzuty do regionalnych węzłów chłonnych, nieradykalna operacja pierwotna. Uzupełniająca radioterapia polegała na napromienianiu na obszar miednicy w dawce 43,2 do 46 Gy z następową brachyterapią dopochwową - LDR w dawce 35 Gy, specyfikowanej na głębokości 0,5 cm od powierzchni aplikatora. Posługując się wielowariantową analizą według modelu hazardu proporcjonalnego Cox'a, oceniono znaczenie prognostyczne wybranych czynników rokowniczych. Okres obserwacji po leczeniu wynosił minimum 60 miesięcy. Wyniki. Spośród 96 chorych objętych obserwacją, okres 5 alt bez objawów choroby przeżyło 78 (81 proc.) kobiet. Odsetek przeżyć 5-letnich w grupie chorych, u których nie stwierdzono przerzutów do węzłów chłonnych miednicy, wyniósł 92 proc., natomiast z przerzutami do węzłów - 56 proc. (p 0,0004). Analiza wpływu odstępu czasu od zabiegu operacyjnego do rozpoczęcia uzupełniającej radioterapii w grupie 71 chorych, napromienianych uzupełniająco ppo nieoptymalnym zakresie operaacji, dostarczyła następujące wyniki: odsetek przeżć 5-letnich ze średnim czasem ...

    Streszczenie angielskie: Aim. Assessment of the prognostic value of the time interval between surgery and adjuvant postoperative radiotherapy. Material and methods. A retrospective analysis of 96 early stage cervical cancer patients, initially treated with surgery. All patients received postoperative radiotherapy in case of positive pelvic lymph nodes or inappropriate surgical margins. All patients received external beam radiotherapy, dose range 43.2 Gy and 46 Gy, adn additionally, intracavitary brachytherapy - (LDR) with a mean dose 35 Gy, measured at 0.r cm below the vaginal cylinder. Cox's proportional hazards model was performed to evaluate independent factors affecting survival. The incidence of treatment-related toxicity was also recorded and scored according to the RTOG/EORTC toxicity scale. The minimum follow-8- was to months. Results. Among 96 patients in 5-year follow-up, 78 (81 p.c.) were still alibe without evidence of disease. The 5-year disease free survival for the node negative group was 92 p.c., and for the nodes positive group - 56 p.c. (p 0.0004). The analysis of prognostic value of the time interval between surgery and adjuvant radiotherapy for the group of 71 patients has demosntrated that the tiem interval of 32.5, 44.5, and over 60 days, resulted in a 5-year disease - free survival of 91 p.c., 88 p.c. and 83 p.c. respectively. The time interval between surgery and radiotherapy over 60 days was also a significant factor negatively affecting survival (p 0.035). ...


    1732/2523

    Tytuł oryginału: Prognostic value of selected imunohistochemical markers in skin melanoma.
    Tytuł polski: Markery immunohistochemicze w czerniaku.
    Autorzy: Kycler Witold, Grodecka-Gazdecka Sylwia, Bręborowicz Jan, Filas Violetta, Teresiak Marek
    Źródło: Nowotwory 2002: 52 (6) s.487-495, il., tab., bibliogr. 40 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Cel pracy. Celem pracy jest ocena znaczenia metaloproteinazy 2 (MMR-2), glikoproteiny CD44 i nm23 kinazy dwufosfonukleozydowej dla przebiegu czerniaka skóry w porównaniu z wpływem czynników klinicznych i histopatologicznych na czas przeżycia. Materiał i metodyka. Analizowano dane 39 pacjentów operowanych z powodu czerniaka w Wielkopolskim Centrum Onkologii w Poznaniu w II Oddziale Chirurgii Onkologicznej po raz pierwszy w latach 1990 - 1994. Ocenie poddano dane kliniczne, takie jak: wiek, płeć, pojawienie się rozsiewu nowotworowego, jego lokalizację oraz czas przeżycia. Na podstawie archiwalnych preparatów histopatologicznych oceniono: grubość nacieku guza w mm wt Breslow'a, poziom naciekania wg Clarka, postać histologiczną, obecność nacieku limfocytarnego, cechy regresji, obecność owrzodzenia, obecność satelitów i przerzutów do węzłów chłonnych. Przeprowadzono badanai ekspresji narkerów immunohistochemicznych w materiale tkankowym uzyskanym z archiwalnych bloczków parafinowych. Określono obecność HMB-45 i PCNA, ekspresję metaloproteinazy 2 (MMP-2, glikoproteiny CD44 i nm23 kinazy dwufosfonukleozydowej. Dane kliniczne, histopatologiczne i immunohistochemiczne oceniono w korelacji z czasem przeżycia. Ocenę czynników prognostycznych przeprowadzono metodą nieparametrycznego modelu proporcjonalengo hazardu wg Coxa. Wyniki. Najistotniejszym czynnikiem rokowniczym w badanej grupie okazał się dodatni wynik reakcji na obecność nm23 kinazy dwufosfonukleotyzydowej i to zarówno ...

    Streszczenie angielskie: Aim: to assess the signifcance of the expression of metalloproteinase 2 (MMP-2), CD44 glycoprotein and mn23 diposphate nucleoside kinase on melanoma progression and survival time and its comparison with the influence of clinical and histopathological parameters. Material and methods: 39 patients operated for the first time because of melanoma in the 2nd Department of Oncological Surgery of the Greatpoland Cancer Centre in Poznań between the years 1990 - 1994. Clinical data such as age, gender, the occurrence of cancer spread, its location and survival time were assessed. Using archival histopathological specimens we assessed the thickness of tumour invasion in mm according to Breslow, the level of invasion according to Clark, histological type, the presence of lymphocyte infiltration, regression symptoms, teh existence of preexisting naevus, the presence of ulceration, the presence of satellites and metastases to lymphatic nodes. Immunohistochemcial marker expression was perforemd in tissue material obtained from archival paraffin blocks. The presence of HMB-45 adn PCNA, the expression of metalloproteinase 2 (MP-2), CD44 glycoprotein and nm23 diphosphate nucleoside kinase were also assessed. Clinical, histopahtological and immunohistochemcial data was analysed in correlation with survival time. The evaluation of prognostic factors was performed aby Cox's nonparametriic proportional hazard regression model. Results: the crucial prognostic factor in the examined group ...


    1733/2523

    Tytuł oryginału: Indications for boost irradiation after quadrantectomy for early breast cancer.
    Tytuł polski: Radioterapia u chorych z wczesnym rakiem sutka po kwadrantektomii - wskazania do podwyższenia dawki na wydzielone pole ("boost").
    Autorzy: Marinova Lena, Hadjieva Tatiana
    Źródło: Nowotwory 2002: 52 (6) s.497-501, il., tab., bibliogr. 21 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie polskie: Wstęp. Istnieją kontrowersje dotyczące stosowania podwyższonej dawki na wydzielone pole ("boost") u chorych po kwadrantektomii, wykonanej we wczesnym raku sutka. Materiał i metody. Przeprowadzono retrospektywną analizę 341 chorych z rakiem sutka w stadium pTNM I/II (guz poniżej 3 cm średnicy) po kwadrantektomii pod kątem oceny stosowania podwyższonej dawki na wydzielone pole ("boost") w celu zapewnienia kontroli miejscowej, mierzonej jako czas przeżycia bez wznowy (Recurrence Free Survival, RFS) i w efekcie, czas przeżycia bez choroby (Disease Free Survival, DFS). Podawano dawkę 50 Gy (techniką teleradioterapii kobaltowej) na całą pierś, bliznę pooperacyjną i ścianę klatki piersiowej, a u 224 chorych dodatkowo "boost" 10 Gy, skierowany na lożę po guzie. Wyniki i wnioski. W ciągu 10 lat obserwacji nie stwierdzono statystycznie znamiennej różnicy w zakresie odsetka RFS: 96 proc. w grupie 224, które otrzymały "boost" i 95 proc. w grupie 117 chorych, które nie otrzymały "boostu". Odsetek DFS był w 10-tym roku obserwacji taki sam w obu grupach - tj. 89 proc. Odsetek wznów miejscowych po 10 latach należał do najniższych opisywanych w literaturze - 3,4 proc. w grupie, która otrzymała "boost" i 3,6 proc. chorych w grupie, która nie otrzymała "boostu". Analiza wieloczynnikowa metodą Coxa pozwoliła wyłonić grupę chorych o podwyższonym ryzyku wznowy miejscowej, które mogłyby odnieść wyraźną korzyść z naświetlania, z zastosowaniem podwyższonej dawki na wydzielone pole. Są to chore, u których rozmiary guza osiągają 2,1 - 3 cm, nowotwór zaś wykazuje cechę G3 i nie posiada receptorów stseroidowych.

    Streszczenie angielskie: Introduction. Controversies still exist on boost irradiation after quadrantectomy for early breast cancer. Material and methods. A retrospective study on 341 p/TNM I-II staged ( 3 cm) patients aimed to evaluate boost irradiation effect mainly upon local tumour control, measured by Recurrece Free Survival - (RFS) and consequently to Disease Free Survival (DFS). Whole breast, scar and chest wall were irradiated by 50 Gy telecobaltherapy in all patients and 224 of them were chose to receive additional 10 Gy to the tumour bed. Results and conclusion. No significant difference was registerd in 10 years RFS (96 p.c.) in 224 patients receiving 10 By boost irradiation, compared to 95 p.c. RFS of the 117 patients irradiated with 50 Gy to the whole breast. DFS was 89 p.c. at 10th year and did not differ in both groups. The local relapse rate at 10th year was among the lowst figures reported - 3.4 p.c. for boost group and 3.6 p.c. for no-boost group. Proportional hazard COx model reveal a high-risk group for local recurrence that might benefit from boost irradiation (tumour size 2.1 - 3 cm; G3, negatives steroid receptors). In our practice patients developing such characteristics have indications for boost irradiation.


    1734/2523

    Tytuł oryginału: Hair transplantation for the treatment of post-irradiation alopecia.
    Tytuł polski: Przeszczep włosów w leczeniu łysienia po napromienianiu.
    Autorzy: Kolasiński Jerzy, Kolenda Małgorzata, Skowronek Janusz
    Źródło: Nowotwory 2002: 52 (6) s.502-505, il., tab., bibliogr. 31 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wstęp. Leczenie chorób nowotworowych w obrębie głowy i szyi, a także leczenie białaczek wymaga często radioterapii. Konsekwencją takiego postępowania jest wielokrotnie trwałe łysienie obszarów skóry owłosionej głowy, podanej ekspozycji na promieniowanie. Materiał i metody. Jednym ze skutecznych sposobów leczenia łysienia poradiacyjnego jest przeszczep włosów. W okresie 18 lat leczono w Hair Clinic Poznań 42 pacjentów z powodu łysienia popromiennego. Ze względu na zmiany w obrębie skóry okolicy biorczej i dawczej zastosowano szereg modyfikacji korekcji łysienia. Wyniki. Zastosowane leczenie pozwoliło na uzyskanie satysfakcjonujących efektów kosmetycznych bez ryzyka wystąpienia powikłań. Dyskusja. Włosy pobrane w okolicy potylicznej głowy, nie podlegają łysieniu, a przeniesione w okolic łysiejące zachowują swoje właściwości i pozwalają uzyskać odrost włosów. Przeszczep włosów jest zwykle stosowany w korekcjach łysienia androgenowego u mężczyzn i kobiet, jak również w leczeniu łysienia po urazach i radioterapii. Odrost włosów u pacjentów po radioterapii następuje później niż u pacjentów z łysieniem androgenowym. Jest to spowodowane gorszym ukrwieniem okolicy biorczej. Podsumowanie. Autogenny przeszczep mieszków włosowych jest leczeniem z wyboru w korekcji łysienia popromiennego, a uzyskanie dobrego efektu kosmetycznego znacznie poprawia komfort życia pacjentów.

    Streszczenie angielskie: Introduction. Treatment of head and neck tumours and of leukaemia often necessitates radiotherapy. However, permanent alopecia in the scalp exposed to irradiation is a common problem. Material and methods. One of the effective methods of treatment of post-irradiation alopecia is hair transplantation. Over a period of 18 years 42 patients were treated at the Hair Clinic Poznań for post-irradiation alopecia. Dut to the presence of numerous lesions in the donor and recipient scalp areas many modifications were introduced into alopecia correection. Results. The treatment assured good cosmetic effects, free of te risk of complications. Discussion. Scalps from occipital areas do not go bald when transferred to scalp areas afected by balding. On the contrary - they retain original properties, thus resulting in hair re-growth. Hair follicle transplantation is usually applied for the correction of androgenic alopecia in men and women although it may also be applied in post-trauma and post-irradiation alopecia treatment. Hair regrowth in radiotherapy patients occurs later than in androgenic alopecia patients. This phenomenon is caused by blood supply deficits in the recipient area. Summary. Autogenic hair follicle transplantation is a treatment of choice in the correction of post-irradiation alopecia, while the good cosmemtic efects considearably improve the patients' quality of life.


    1735/2523

    Tytuł oryginału: Brachytherapy in an advanced stage of pancreatic cancer - a case report.
    Tytuł polski: Brachyterapia w zaawansowanym raku trzustki - opis przypadku.
    Autorzy: Kycler Witold, Teresiak Marek, Skowronek Janusz, Łaski Piotr
    Źródło: Nowotwory 2002: 52 (6) s.506-508, bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie polskie: Rak trzustki rozpoznawany jest zwykle w późnych stopniach zaawansowania klinicznego. Ogranicza to w znacznym stopniu możliwości zastosowania radykalnego leczenia chirurgicznego. Aktualne coraz częściej stosuje się brachyterpię HDR jako leczenie palaitywne w zaawansowanych rakach trzustki. Leczenie neoadjuwantowe oparte na brachyterapii HDR stwarza w niektórych przypadkach możliwość zahamowania wzrostu guza i zmniejszenia miejscowego zaawansowania. Przedstawiamy opis leczenia pacjenta z miejscowo zaawansowanym rakiem trzustki, u którego zastosowano brachyterapię HDR.

    Streszczenie angielskie: Treatment options for pancreatic cancer remain limited due to the large proportion of patients presenting with advanced disease at the time of diagnosis. Literature reports emphasize the advantages arising from palliative treatment using HDR brachytherapy. The promising results have provided encouragement for extendign the application of this method. Neoadjuvant therapy may stop tumor growth or induce regression of local tumor advancement. We present a case of a patient with locally advanced pancreatic cancer treataed with interstitial brachytherapy at the Greatpoland Center Centre in Poznań.


    1736/2523

    Tytuł oryginału: Methodology to predict long-term cancer survival from short-term data using Tobacco Cancer Risk and Absolute Cancer Cure models.
    Autorzy: Mould Richard F.
    Źródło: Nowotwory 2002: 52 (6) s.509-511, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 313,490

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1737/2523

    Tytuł oryginału: VIII Polish Conference on Cell Biology, Wrocław, September 23-25, 2002. Abstracts.
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 suppl. s.1-346, tab. - 8 Polska Konferencja nt. biologii komórki Wrocław 23-25.09. 2002
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny


    1738/2523

    Tytuł oryginału: Pulsatile extracorporeal circualtion - let it be?
    Autorzy: Ng Calvin S. H., Wan Song, Yim Anthony
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.ED17-ED19, bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cardiopulmonary bypass (CPB) is known to induce a whole body inflammatory response. Since the 1970's, a number of trials have explored the effect of pulsatile CPB on systemic organ function and inflammatory response. Clinical benefits of neuroprotection, improved myocardial and splanchnic perfusion, as well as attenuated systemic inflammatory response have been reported. However, skepticism for pulsatile CPB remains because of inconistencies of clinical benefits and 'non-standardized' trials. Tarcan and colleagues compared clinical, haemodynamic, biochemical and haematological parameters in patients with chronic obstructive pulmonary disease undergoing CPB with pulsatile flow versus those without. They found higher circulating white cell count and lower neutrophil count at 1 hour post-operatively in the pulsatile gorup compared with non-pulsatile group, which was attributed to higher pulmonary neutrophil sequestration. In addition, the pulsatile CPB group had lower pulmonary vascular resistance at 1 hour post-operatively and shorter ventilation time. In the current study, confirmation for pulmonary neutrophil sequestration in the form of bronchoalveolar lavage (BAL) or histology would have been welcomed, and additional markers such as neutrophil elastase or matrix metello-proteinases in BAL, and other measurements of lung function may help clarify the association between neutrophil sequestration, lung injury and clinical endopoints. The role of pulsatile CPB in certain high-risk patients remain uncertain, and until more definite evidence of benefit is available, we should be cautious of its universal application.


    1739/2523

    Tytuł oryginału: Fluoxetine differentially suppresses sucrose solution consumption of free-fed and food-deprived rats - reversal by amantadine.
    Autorzy: Prendergast Mark A., Yells David P., Balogh Scott E., Paige Stephen R., Hendricks Shelton E.
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR385-BR390, il., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Clinical use of fluoxetine and similar medications is often associated with appetite suppression and weight loss that may warrant drug discontinuation. It is unclear, however, if fluoxetine induced consummatory suppression may be influenced by factors such as dietary status and if appetite suppressant effects of fluoxetine may be pharmacologically attenuated. Material/Methods: Fluoxetine (0.5 - 10 mg/kg, i.p.) was administered to free-fed and 24 hr food-deprived adult male rats either 30 min or 4 hr prior to presentation of a sucrose solution (10 p.c. v/v). Further, amantadine (5 - 10 mg/kg, i.p.) and fluoxetine (5 mg/kg) were both administered either 30 min or 4 hr prior to sucrose solution presentation and intake of the solution was assessed after 2 hours of exposure. Results: Fluoxetine (2 - 10 mg/kg) administration significantly reduced sucrose solution intake in both free-fed and food-deprived rats. However, a brief treatment-test interval (30 min) resulted in a greater suppression of intake and food-deprived rats were more resistant to the suppressant effects of fluoxetine than were sated rats. Finally, the suppressant effect of fluoxetine were reversed by acute administration of amantadine (8 mg/kg) prior to sucrose solution presentation, a dose producing no inherent stimulation of consumption. Conclusion: Acute fluoxetine administration produces a reduction in palatable substance intake that is decreased in potency with a longer treatmet-test interval, an effect likely not related to pharmacokinetic considerations. Further, fluoxetine-induced consummatory suppression is reduced by prior food-deprivation. Evidence that the dopamine agonist amantadine reversed fluoxetine-induced consummatory suppression suggests a role for dopaminergic antagonism in the appetite suppressant effects of fluxetine.


    1740/2523

    Tytuł oryginału: Unstable receptors disappear from cell surface during poliovirus infection.
    Autorzy: Neznanov Nickolay, Chumakov Konstantin P., Ullrich Axel, Agol Vadim I., Gudkov Andrei V.
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR391-BR396, il., bibliogr. 24 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Background: Cellular recptors play a significant role in pathogenesis of viral infections. Previously, we demonstrated that TNFŕ receptor (TNFR1) rapidly disappeared from the cell surface upon poliovirus infection, whereas FAS was much more stable [1]. We suggested what the rate of decrease in receptor presentation on the surface of infected cells might reflect its turnover rate on uninfected cells. Material/Methods: To test this hypothesis, we estimated by FACS analysis the turnover rates of receptors for TRAIL (TRAILR1 and TRAILR2), signal regulatory protien SIRPŕ, receptor for ŕ/á interferon (INFR1), and poliovirus receptor (CD155) on the surface of HeLa cells after the treatment with brefeldin A (to stop receptor replenishment through the Golgi-mediated trafficking) or polivirus infection. Results: A good correlation between turnover rates caused by the two interventions was observed, with the stability of receptor presentation changing in the following order: TRAILR1, TRAILR2, SIRPŕ (half-life on infected cells between 2-4 h) INFR1 (4-6 h) CD155 ( 8 h, besides some early masking of the receptor by its binding of the virus). Conclusion: Our results suggest that disruption of the protein trafficking pathway during polivirus infection leads to the diminished sensitivity of infected cells to pro-apoptotic factors, and thus represents one of the mechanisms by which virus modulates the host defense reactions.


    1741/2523

    Tytuł oryginału: Mifepristone (RU-486) impairs post-surgical wound healing of the larynx.
    Autorzy: Tcacencu Ion
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR397-BR400, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • płeć męska

    Streszczenie angielskie: Background: The purpose of this study was to examine how RU486 (mifepristone), a glucocorticoid antagonist, affects the regeneration process in a rabbit laryngeal wound-healing model. Material/Methods: Eight rabbits underwent a cricoid-split operation with collagen sponge insertion. The animals were classified randomly into two groups (4 animals in each group): the RU486-treated group, with local administration of 3 mg RU486, and the control gorup, which was sham treated. The specimens were harvested seven days after surgery. Histomorphometric analysis was performed to evaluate the healing pattern of the layrnx wound. Results: Respiratory epithelium regeneration was delayed in the RU486-treated group. The proliferation of granulation tissue was also increased. Polyps were detected in 3 specimens from this group. No obvious differences with regard to inflammatory cell infiltration were found. Conclusion: RU486 impairs post-surgical wound healing of the larynx by increasing the presence of granulation tissue and polyps, and appears to delay re-epithelialization.


    1742/2523

    Tytuł oryginału: Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats.
    Autorzy: Frenoux Jean-Marie R., Noirot Beatrice, Prost Emmanuelle D., Madani Sihem, Blond Jean Paul, Belleville Jacques L., Prost Josiane L.
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR401-BR407, tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Oxidative stress is closely related to cardiovascular diseases, suchas atherosclerosis. Increasing dietary antioxidants, such as ŕ-tocopherol, may prevent these diseases. However, in some pathologies, such as hypertension, oxidative stress is enhanced, thus ŕ-tocopherol requirements may be raised. Material/Methods: In eleven-week-old spontaneously hypertensive rats and normotensive Wistar Kyoto rats, we investigated the effects of a four-week very high ŕ-tocopherol dietary enrichment (1200 mg/kg diet, VH) on blood pressure, resistance to free radical aggression, and VLDL+LDL resistance to lipid peroxidation. Platelet aggregation and plasma lipid profile were also investigated. Results: With either diet, hypertensive rats were more protected against oxidative stress than normotensive rats. Their capacity to withstand free radical aggression was better, and their WLDL+LDL particles were less sensitive to lipdid peroxidation. In either group, the VH diet did not modify blood pressure values when resistance to free radical aggression was incrased, but not the resistance of VLDL+LDL to lipid peroxidation. With the control diet, platelet aggregation was fastsesr and higher in hypertensive rats vs. normotensive rats. It was decreased with the VH diet in hyeprtensive rats but increased in normotensive rats, when compared to their respective controls. Whatever the diet, plasma triacylglycerol, phospholipid and cholesterol concentrations were lower in hypertensive than in normotensive rats. Only cholesterol concentrations were diminished with the VH diet in hypertensive rats, but not in normotensive rats. Conclusion: These results indicate that very high ŕ-tocopherol dietary amounts decrease cardiovascular risk in hypertensive rats with high oxidative stress, but have less effect on normotensive rats.


    1743/2523

    Tytuł oryginału: Locomotion of human granulocytes in viscous media.
    Autorzy: Jakubas-Przewłocka Jadwiga
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR408-BR413, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: Granulocytes must migrate to the infection site, where they phagocytose the infecting agents. Their ability to migrate depends on the rheological properties of the cells, which change along with the increased viscosoty of the suspension medium. The purpose of this research was to study the influence of medium viscosity on granulocyte locomotion. Material/Methods: The random locomotion of human granulocytes was investigated by means of an assay based on direct observation of individual cell trajectories. The study was performed in viscous media, ranging from 0.7 x 10**-3 to 370 x 10**-3 Paús (0.7 - 370cP). Hanks solution, supplemented with methylcellulose in various concentrations, was used as a medium. The locomotion of several hundred granulocytes was studied, and about 7000 cell track-sections (steps) were recorded. Results: The mean granulocyte velocity decreases slowly with incrasing medium viscosity. An increase in medium viscosity of ca. 500 times results in only a three-fold reduction in velocity. Granulocytes can migrate even at the viscosity of thick honey. They are capable fo overcoming resistance forces on the order of 10**-11N. The locomotion of granulocytes in dextran and ficoll media is also described. In these media both viscosity and osmotic pressure were variable. Granulocytes stop moving at very low viscosity, on the order of 10**-3 Paús. Conclusions: The locomotion of granulocytes is not stopped even in media of high viscosity. THe observed decrease of granulocyte velocity is comparatively small. The studies in dextran and ficoll media indicate significant influence of osmotic pressure on granulocyte locomotion.


    1744/2523

    Tytuł oryginału: Pre-degenerated peripheral nerve extracts applied to the proximal stump of transected sciatic nerve enhance both regeneration and autotomic behavior in rats.
    Autorzy: Lewin-Kowalik Joanna, Marcol Wiesław, Larysz-Brysz Magdalena, Wolwender Katarzyna, Pietrucha-Dutczak Marita, Górka Dariusz
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR414-BR420, il., bibliogr. 42 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Peripheral nerve regeneration after traumatic injury and standard repair with a nerve autograft is often incomplete and results in neuropathic pain. Peripheral nerve extracts applied to the proximal nerve stump by means of autologous, dead-ended connective tissue chambaers (deCTC) are known to accelerate the rate of acon regeneration. This study tested if such extracts would influence autotomy, which is a behavioral measure of neuropathic pain in animal models. Material/Methods: The study was performed on Wistar rats. DeCTCs, filled with postmicrosomal fraction obtained from 7-day-predegenerated nerves (7D group) or fibrin (F group), were implanted into transected sciatic nerve. In the control group (C), sciatic nerve was transected and its distal part was removed. The self-mutilation behavior in rats was assessed daily for seven weeks after sciatic nerve transcetion. The onset as well as intensity of autotomy was measured. The progress of regeneration was assessed under light microscopy and histochemistry. Results: The earliest onset and gratest severity of autotomy were found in teh 7D group. Regeneration progress was also highest in this group. In the F group, we found weaker regeneration and less autotomy. The control group showed no regeneration, but more autotomy than the F group. Conslusion: Intensifeid autotomy may be teh price paid for enhanced peripheral nerve regeneration after application of growth-promoting substances.


    1745/2523

    Tytuł oryginału: Characterization of Fanconi anemia fibroblasts in terms of clonogenic survival and DNA damage assessed by the Comet assay.
    Autorzy: Djuzenova Cholpon S., Flentje Michael
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR421-BR430, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • radiologia
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Response of Fanconi anemia (FA) cells to X-irradiation is controversial. Present study was undertaken to compare short-term and long-term responses of irradiated FA fibroglasts. Material/Methos: Skin fibroblasts derived from FA patients were studied using to the Comet assay, clonogenic survival, apoptosis and cell cycle checkpoint arrest. Fibroblasts derived frim ataxia telngiectasia (AT) pateitns served as positive controls. Results: The alkaline Comet assay showed that the initial DNA fragmentation in irradiated FA fibroblasts is similar to or even higher than in AT cells. Moreover, the DNA rejoining ocurred slowly in FA fibroblasts than in AT cells. In contrast, the colony assay revealed that the survival of X-ray-irradiated FA fibroblasts is higher than that of irradiated AT cells. Unlike FA fibroblasts, which were arrested in teh Gl phase of the cell cycle by X-irradiation, AT cells displayed a pronounced G2/M arrest after X-ray exposure. Conclusions: FA cells are shown to be radioresistant by clonogenic survial but display high tail moments in the Comet assay suggesting high initial DNA damage and reduced repair capacity. It is demonstrated that the solony assay can not explain the high radiosensitivity of FA patients. The Comet assay can help to obtain additional information on initial DNA damage and repair capacity.


    1746/2523

    Tytuł oryginału: Heart rate variability in infants with heart failure due to congenital heart disease: reversal of depressed heart rate variability by propranolol.
    Autorzy: Buchhorn Reiner, Hulpke-Wette Martin, Nothroff J”rg, Paul Thomas
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR661-CR666, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: Background: Analysis of heart rate variability (HRV) provides a noninvasive index of autonomic nervous system activity. HRV has shown to be reduced in congestive heart failure and in children with congenital heart disease (CHD). Beta-blockers improve HRV in adults with congestive heart failure, but this improvement remains to be demonstrated in children. Material/Methods: HRV was analysed in 14 infants with severe heart failure due to CHD who received a 'standard' therapy with digoxin and diuretics ('Digoxin/Diuretics' group) adn in 9 of these patients with and additional propranolol therapy ('Propranolol' group) 17 days alter on average adn compared with HRV of 70 healthy infants ('Healthy Control'). Results: Comparing the 'Digoxin/Diuretics' group versus 'Healthy Control', we found significantly reduced HRV in the time domain and the frequency domain, that could be abolished in the 'Propranolol' group. None of teh HRV parameter were significantly related to age or any hemodynamic parameter but inversely related to ejection fractions within the normal range (pNN50: r = -0.58, p = 0.004; rMSSD: r = -0.42: p= -0.049). HRV measurements (SDNN, r = -0.48) and plasma norepinephrine levels (r = 0.7) were significantly related to clinical symptoms of heart failure, measured by the Ross Score. Conclusion: HRV represents a noninvasive parameter that is reduced in infants with congenital heart disease depending on the severity fo heart failure but not on hemodynamic disturbances. Propranolol but not digoxin therapy effectively reduced the supposed autonomic imbalance in infants with severe heart failure due to CHD.


    1747/2523

    Tytuł oryginału: Potential of CT-scan based tumor volume as a response indicator in chemotherapy of advanced epithelial ovarian cancer.
    Autorzy: Kumar Pratik, Rehani Madan Mohan, Kumar Lalit, Sharma Raju, Bhatla Neerja, Singh Rajvir, Sundaram K. Ramaiyer
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR667-CR674, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Background: Response prediction in patients undergoing chamotherapy for ovarian cancer is an important issue, since the cure rate is only about 15 - 20 p.c. We attempted to develop a semi-empirical model to predict response in individual cases after the first cycle of chemotherapy. Material/Methods: This prospective study included 51 cases of advanced ovarian cancer. A method was standardized to estimate ovarian tumor volume accurately from CT scan films. This permits the inclusion of patients who have undergone CT scan elsewhere. Patients underwent 4 - 6 cycles of chemotherapy and tumor volume was estimated after each cycle. This yielded a tumor regression curve for each patient. Results: Percent reduction in tumor volume after the first chemo-cycle was a significant prognostic factor in multivariate analysis. Depending upon the rate of regression patients could be classified into Fast Regressing FR (n = 29) and Moderately Regressing MR (n = 16), whereas 6 patients showed Progressive Disease (PD) despite ongoing chemotherapy. The median survivals for the FR, MR and PD groups were 29.3, 18.9 adn 8.5 months respectively. We found that 'percent reduction in volume after firs chemo-cycle' could categorize a patient as FR/MR/PD correctly in 94.1 p.c. of cases. This parameter could also detect 5 out of 6 inherently resistand PD cases, who would otherwise undergo further chemotherapy, since early detection of resistance by clinical monitoring is quite difficult.


    1748/2523

    Tytuł oryginału: Influence of chronic Helicobacter pylori infection on ischemic cerebral stroke risk factors.
    Autorzy: Majka Jolanta, Róg Teresa, Konturek Peter C., Konturek Stanisław J., Bielański Władysław, Kowalsky Marek, Szczudlik Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR675-CR684, il., tab., bibliogr. 100 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Infection by Helicobacter pylori (Hp) has been linked to extradigestive pathologies including ischemic cerebral disease. The aim of our study was to assess the relationship between chronic Hp infection and ischemic stroke risk factors. Material/Methods: 80 patients (pts) aged 60 - 75 years with ischemic stroke confirmed by CT scans (group I) and 80 age- and gender-matched healthy controls (group II) were included into trial. Atherosclerotic plaques from 20 Hp positive pts were obtained at carotid endarterectomy for Hp DNA assessment by PCR. In all groups following parameters were determiend; 1) the prevalence of Hp infection using 13C-Urea Breath Test (UBT), 2) plasma anti-Hp and anti-CagA IgG and interleukin-8 (IL-8), and 3) palsma lipids and fibrinogen. Hp positive pts and controls received one-week anti-Hp therapy and after six months total cholesterol, low-density lipoprotein (LDL)-cholesterol, fibrinogen and IL-8 levels were re-examined. Results: Hp infection was detected by UBT in 83.75 p.c. of stroke pts but only in 65 p.c. of controls. DagA seropositivity was also significantly higher in stroke pts (57.5 p.c.) than in controls (33.75 p.c.). Plasma levels of cholesterol, LDL-cholesterol and fibrinogen as well as IL-8 were significantly higher in Hp positive subjects, especially in pats with ischemic stroke. Six months following successful anti-Hp therapy, the plasma levels of total cholesterol, LDL-cholesterol, fibrinogen and IL-8 were significantly lower than those in Hp positive stroke pts and contorls. Conclusions: Hp infection represents risk factor of ischemic stroke via an interaction of Hp cytotoxings of cytokines with atherosclerotic plaques in carotic arteries.


    1749/2523

    Tytuł oryginału: Serum leptin levels in acromegaly - a significant role for adipose tissue and fasting insulin/glucose ratio.
    Autorzy: Bolanowski Marek, Milewicz Andrzej, Bidzińska Bożena, Jędrzejuk Diana, Daroszewski Jacek, Mikulski Emil
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR685-CR689, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Leptin plays an important role in controlling safety and mainatining energy balance. Acromegaly is characterized by decreased fat, which increases after the disease is cured. Out objective was to investigate serum leptin in acromegaly in terms of disease activity, body fat content, insulin and glucose levels, and selecated anthropometric variables. Mateirl/Methods: We examined 40 patietns with acromegaly and 200 sex- adn age-matched controls for the levles of serum GH, IGF-I, leptin, glucose, and insulin, and for body composition by DEXA, BMI and WHR. In 10 cases the acute ef fect on serum leptin of a somatostatin analogue, lanreotide, was studied. Results: We observed lower elptin in patients with active acromegaly than in cured patients and controls. Body fat was higher in cured than active patients. In the patients, we found significant correlations (p 0.05) between leptin and percent body fat (r = 0.77), leptin and body fat mass (r = 0.74), leptin and fasting insulin (r = 0.62), leptin and fasting insulin/glucose ratio (r = 0.97), leptin adn BMI (r = 0.44), leptin and height (r = -0.47). In the controls there was a significant correlation (p 0.05) o0nly between leptin and WHR (r = -0.45). A paradoxical decrease of the leptin after lanreotide was observed in ;7 out of 10 patients with active acromegaly. Conclusions: Changes in leptin release in acromegaly are related to differences in body fat content and mass, and in insulin resistance. Leptin in acromegaly is not influenced directly by GH or IGF-I secretion. The acute effect of medical treatment of acromeagly by a somatostatin analogue on leptin levels differes from teh effect of a radical cure following pituitary adenoma surgery.


    1750/2523

    Tytuł oryginału: Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy.
    Autorzy: Dłużniewska Joanna, Zolich Dorota, Polański Jerzy, Zając Leszek, Sitkiewicz Dariusz, Łukomska Barbara
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR690-CR696, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The purpose of our study was to investigate hepatocyte proliferation and the expression of hepatocyte growth factor (HGF) in liver tissue and blood from patients with benign and malignant liver tumors after partial hepatectomy. Material/Methods: We studied 25 consecutive patients undergoing partial hepatectomy for metastatic colorectal adenocarcinoma (15 cases) adn benign liver tumors (10 cases). Immunohistochemical examination for teh rpesence of PCNA adn HGF, c-Met/HGF-receptor expression was performed on formalin-fixed samples from: a) sections of resected fragments of liver tissue remote from the tumor; b) tumor tissue; c) remnant liver, 30 min after hepatectomy; d) fine needle aspiration liver biopsy, 7 days after liver resection. Circulating HGF and the level fo AFP adn GGT as biomarkers for liver cell regeneration were measured in the patients' blood at the same time. Results: The proliferation rate of liver cells was higher in patients with malignant than benign liver tumors. This correlated with incrased HGF in blood, but not with the expression of HGF and c-MET/HGF-R in liver tissue. The expression of HGF was detected in specimens from colorectal liver metastases. Conclusion: The mutual interactions between tumor and other cells may influence the proliferation of hepatocytes throughout the regenerative process in patients with colorectal carcinoma metastases after partial hepatectomy.


    1751/2523

    Tytuł oryginału: Comparative analysis of lipid profiles assessed by ultracentrifugation in patients with various hyperlipoproteinaemia types in correlation with hepatic steatosis.
    Autorzy: Tacikowski Tadeusz, Dzieniszewski Jan, Nowicka Grażyna, Ciol Janusz
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR697-CR701, tab., bibliogr. 41 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our study was to compare lipid profile assessed by ultracentrifugation in various types fo hyperlipoproteinemia (HLP) in correlation with obesity and hepatic steatosis diagnosed in the ultrasonic examination of the abdominal cavity. Material/Methods: We studied 64 patients (38 women adn 26 men with a mean age of 53.5 years) with various types of HLP, divided into two groups: 1) hypercholesterolemia, 2) mixed hyperlipoproteinemia. Lipid profile by ultacentrifugation was performed simultaneously with ultrasonic examination. Results: Among 33 patients with hypercholoesterolaemia, 7 had hepatic steatosis (21.2 p.c.), with a mean serum TG concentraation significantly higher than in those patients without steatosis. Of the mixed HLP patients, 16 had hepatic steatosis (51.5 p.c.), with a mean serum TG level over twice the concentration found in patients without steatosis. We found significantly higher levels of total cholesterol adn triglycerides in patients with steatosis than in those without. In the HDL fraction, the cholesterol concentration was lower (38.4 mg/dl) in cases of steatosis than in cases without (48.0 mg/dl). Conclusions: Patients with steatosis showed features characteristic of insulin resistance syndrome, i.e. higher BMI values, higher mean serum TG, and low HDL cholesterol concentrations. In patients with hypercholesterolemia and hepatic steatosis, increased serum triglycerides are associated with increased TG concentration in the VLDL fraction. Mixed HLP patients with hepatic steatosis have higher TG adn cholesterol in the VLDL fraaction, adn in these cases a significant rise in total TG is observed.


    1752/2523

    Tytuł oryginału: Hyperthermia is not an independent predictor of greater mortality in patients with primary intracerebral hemorrhage.
    Autorzy: Szczudlik Andrzej, Turaj Wojciech, Słowik Agnieszka, Strojny Jacek
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR702-CR707, tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Our goal was to identify independent early predictors of 30-day mortality in patients with medically treated primary intracerebral hemorrhage (PICH), and to assess the prognostic significance of hyerpthermia in these cases. Material/Methods: We prospectively studied 152 patients wtih supratentorial PICH confirmed by CT on admission. We recorded gender, age, severity of neurological deficit on admission (Scandinavian Stroke Scale), level of consciousness at admission and one day later, and maximum body temperature for the first three days after onset. Hematoma size and midline shift were assessed by CT scans. Outcome was measured by either mortality or Barthel Index functional status 30 days after stroke. Results: 59 patietns (38.8 p.c.) died within 30 days. Patients who died had greater neurological deficit on admission and higher maximum temperature within the first 24 hours after admission, and were more likely to have impaired consciousness on admission and after 24 hours, as well as large hematoma and midline shift (p 0.05 for all differences). However, statistically only severity of neurological deficit was an independent predictor of 30-day mortality. The functional status of survivors who had hyperthermia was much worse than those who wer normothermic on Day 1. Conslusions: The severity of neurologcal deficit predicts greater 30-day mortality in patients with primary intracerebral hemorrhage. Patients with hyperthermia on the first day of hospitalization have greater 30-day mortality and worse functional status 30 days after stroke, but increased body temperature is not an independent predictor of 30-day mortality after PICH.


    1753/2523

    Tytuł oryginału: Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis.
    Autorzy: Andreasyan Nune A., Hairapetian Hripsime L., Sargisova Yelizaveta G., Mardanyan Sona S., Badalyan Lena T., Khanoyan Armen S.
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR708-CR712, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The problem of tuberculosis is increasing in a number of countries. Adenosine deaminase activity is considered in many clinics to be avaluable biochemical test of this pathology. Considerable research has been devoted to the activity of enzyme isoforms as significant tests for diagnosing tuberculosis. Material/Methods: The leve of adenosine deaminase and teh activity of its two isoenzymes in the pleural fluids of patients with tuberculous and non-tuberculous pleurisy were compared. Results: The adenosine deaminase level in tuberculous pleural effusions was higher than in non-tuberculous pleural effusions. The data we obtained suggest that the enzyme acitavity level could be a very reliable test in the differential diagnosis of tuberculous pleurisy in the Armenian population. The activity of isoenzymes ADA1 adn ADA2, or their ratios to the total ADA actiavity, throug valuable information, has no diagnostic advantage over total ADA activity in daignosing this pathology. Conclusions: The results clearly point up the value of using a total ADA activity assay in Armenian clinics for the differential daignosis of tuberculous pleurisy. Determinations of the activity level of the ADA1 adn ADA2 isoenzymes provide no diagnostic advantage over total ADA activity.


    1754/2523

    Tytuł oryginału: Analysis of collagen IV and fibronectin in blood and urine in evaluation of nephrotic fibrosis in children with chronic glomerulonephritis.
    Autorzy: Kiliś-Pstrusińska Katarzyna, Wikiera-Magott Irena, Zwolińska Danuta, Kopeć Wacław, Rzeszutko Marta
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR713-CR719, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Changes in teh concentration of extracellular matrix components in body fluids may reflect the degree of kidney fibrosis. The aim of our study was to evaluate fibronectin (FN) and type IV collagen (COL IV) concentrations in blood serum and urine, and to refer these values to immunoreactivity in renal biopsy material. Material/Methods: Our research involved 37 children with glomerulonephritis (GN) aged 4 - 15 and 18 healthy children. The patients were divided into 3 groups accordign to the histopathological diagnosis of GN (n = 13). Results: Significantly higher COL IV concentrations in serum and uring wer noted in the patients group in comparison to the controls, but no differences in FN concentrations. The highest values of serum and urine COL IV were observed in the LN patients. Positive correlation was found between serum and uring COL IV and its renal content in the LN group. Conclusions: The results indicate that serum and urine COL IV rises in children with GN, above all in the course of LN. This also reflects changes in renal COL IV content.


    1755/2523

    Tytuł oryginału: Serum levels of sTNFR-1 and sFas in patients with relapsing-remitting multiple sclerosis.
    Autorzy: Bilińska Małgorzata, Frydecka Irena, Podemski Ryszard, Gruszka Ewa
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR720-CR723, tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: During the relapse of multiple sclerosis (MS), activated T cells, T cells autoreactive against myelin antigens as well as antigen-nonspecific lymphocytes and monocytes produce a number of proinflammatory cytokines such as TNF (Tumor Necrosis Factor). For a proinflammaoty effect to take place TNF must bind together with appropriate receptors. The aim of the study was to assess value of serum sTNFR-1 adn sFas levels with reference to clinical activation of disease. Material/Methods: Thirty-three patients with clinically documented diagnosis of relapsing-remitting MS and 22 healthy subjects were included in the study. In 15 patients the measurements of sTNFR-1 and sFas levels were performed at the beginning of MS relapse and in 18 subjects - they were taken in MS remission. The levels of both soluble molecules were determined with the use of enzyme-linked immunosorbent assay (ELISA). Results: Mean serum sTNFR-1 levels in patients with MS relapse did not differe significantly from mean sTNFR-1 level in patients with MS remission and a control group. Mean serum sFas level in patients with MS relapse was significantly higher comparing with the results obtained in patients with MS remission and in control group. Conslusions: The absence of changes in serum sTNFR-1 levels relative to clinical activation of the disease makes this measurement ineffective in the assessment of MS status. On the other hand, the measurement of serum sFas levels may be a valuable parameter for the monitoring of both MS clinical couse and immune response to treatment when the symptoms of neurological aggravate.


    1756/2523

    Tytuł oryginału: Alteplase: double bolus versus accelerated regimen.
    Autorzy: Ruiz-Bailen Manuel, Hoyos Eduardo Aguayo de, Hurtado-Ruiz Benjamin, Reina-Toral Antonio, Diaz-Castellanos Miguel Angel, Issa-Khozouz Ziad
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.PI85-PI92, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The purpose of our study was to compare the efficacy and safety fo alteplase in acute myocardial infarction (AMI), when administered in a double bolus regimen or an accelerated regiment during admission to an intensive care or coronary care unit (ICU/CCU). Material/Methods: A retrospective cohort study including all the AMI patients treated with alteplase recorded in the ARIAM register (Analysis of Delay in AMI), a multi-center register in which 77 Spanish hospitals participate. The study period was from January 1995 to January 2000. Results: 4615 AMI patients were studied. THe accelerated regimen (Group I) was administerd to 57.51 p.c. (2,654 patients) and the remaining 42.49 p.c. (1,961 patients) received the double bolus regimen (Group II). There were no differences in mortality or in teh incidence of hemorhagic strokek between the groups. THe mortality was 7.15 p.c. in Group I versus 6.43 p.c. in Group II (not significant). The incidence of hemorrhagic stroke was 1.o9 p.c. in Group I versus 1.22 p.c. in Group II (not significant). Fewer coronary angiograpies were required in Group I (6.28 p.c. vs. 8.99 p.c.; p 0.001) and fewer rescue angioplasties (10.67 p.c. vs. 21.88 p.c., p = 0.03). Group I also showed a smaller requirement for stent insertion (1.45 p.c. vs e.77 p.c.; p 0.0001) and for assistance using intra-aortic balloon contrapulsation (0.47 p.c. vs. 1.36 p.c.; p = 0.02). Conclusions: The two regimens appear to be similar in efficacy and safety. Nevertheless, from these results it may be hypothesized that further revascularization techniques are required after double bolus administration.


    1757/2523

    Tytuł oryginału: Colostrinin proline-rich polypeptide complex from ovine colostrum - a long-term study of its efficacy in Alzheimer's disease.
    Autorzy: Leszek Jerzy, Inglot Anna D., Janusz Maria, Byczkiewicz Franciszek, Kiejna Andrzej, Georgiades Jerzy, Lisowski Józef
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.PI93-PI96, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Colostrinin, a proline-rich polypeptide complex (PRP) isolated from ovine colostrum, with immunoregulatory and procognitive properties, has shown positive effects in the treatment of Alzheimer's disease (AD). The aim of the present study was to evaluate the effects fo long-term Colostrinin treatment of AD patients. Material/Methods: The patients were taking Colostrinin tablets (containing 10 ćg of PRP complex) every other day for three weeks, followed by a 2-weeks hiatus to avoid the development of hyporeactivity. This mode of applicaton, '3+2 weeks', and each patient was evaluated at 4-month intervals, 33 patients were treated for 16 months. however, 14 patients from this group had already been treated with Colostrinin for 12 months during placebo-controlled studies, and thus participated in the trial for a total of 28 months. Results: Teh results we obtained showed that Colostrinin induced slight but statistically significant imporvement or stabilization fo teh health status of teh patients in the trial. THe adverse reactions observed, if any, were remarkably mild, including anxiety, logorrhea, and insomnia, and subsided spontaneously within a short period of tiem (3 - 4 days). Conclusions: Colostrinin is a very promising preparation which can be used to retard the development of AD.


    1758/2523

    Tytuł oryginału: Visualising exposure-disease association: the Lorenz curve and the Gini index.
    Autorzy: Llorca Javier, Delgado-Rodriguez Miguel
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.MT193-MT197, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: It has been suggested that the summary index of teh Lorenz curve, the Gini index, should be used to characterize the exposure-disease association, rather than relative and attributable risks. Neretheless, teh sampling behavior of teh gini index in epidemiological settings, and the relationships between the Lorenz curve and the usual indices of risk, need to be more deeply understood. Material/Methods: The present paper analyzes the geometrical relationships between teh Lorenz curve and the relative and attibutable risks based on two of teh main sampling schemes (cohort and casecontrol designs). Examples for both designs are provided. Gini index confidence intervals are obtained by bootstrap. Results: The Gini index is a function of teh proportion of the population at each level fo exposure, relative risk and attributable risk. If exposure is ordered by increasing levels of risk. The Lorenz curve contains all t;eh information about relative and attibutable risks and distribution of exposure in the population. Therefore, the Lorenz curve easily allows both risks and their distribution in the analyzed population to be visualised. Conclusions: The Lorenz curve and the Gini index can complement the information privided by realtive and attibutable risks.


    1759/2523

    Tytuł oryginału: Down-regulation of nuclear receptor DNA-binding activity by nitric oxide - HNF4 as a model system.
    Autorzy: Vossen Christine, Erard Monique
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA217-RA220, il., bibliogr. 22 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The numerous physiological roles of nitric oxide (NO) are currently teh focus of intensive research. A major pathway by which NO mediates its biological effects is via S-nitrosylation of cysteine residues, and a growing body of evidence suggests that transcription factors are critical targets for such S-nitrosylation. Here we review the ability of NO to down-regulate the activity of transcription factors, and in particular nuclear receptors. Among the latter, the hepatocyte nuclear factor HNF4 stands out as a key regulator of cytochrome P45 (CYP) gene expression. We report on a series fo experients which show that inflammation-induced NO production decreases CYP mRNA transcription, and that NO suppresses the DNA-binding ability of HNF4. Together these data suggest that cysteine-nitrosylation of teh HNF4 DNA-binding domain is the primary molecular mechanism responsible for teh drop in oxydase activities of hepatic cytochrome P450 enzyems, and the consequent impairment in drug metabolism during inflammation. In order to discuss this hypothesis from a structural perspective, we have built a homology-derived model of the HNFe DNA-binding domain and computer-simulated the S-nitrosylation of its cysteine residues. Finally, bearing in mind the structural conservation of the nuclear receptor DNA-binding domain, we discuss to what extent results from HNF4 can be extended to other nuclear receptors.


    1760/2523

    Tytuł oryginału: Allogenic stem cell transplantation following non-myeloablative conditioning regimens as adoptive immunotherapy in patients with hematological malignancies.
    Autorzy: Busca Alessandro, Bruno Benedetto, Boccadoro Mario, Locatelli Franco, Falda Michele
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA221-RA232, tab., bibliogr. 72 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: High-dose chemotherapy followed by allogenic stem cell transplantation has been extensively used for the treatment of patietns with hematological malignancies. Unfortunately, this life saving procedure is limited to a subset of patients who are in good medical condition due to the increased risk of regimen-related toxicity and graft-versus-host disease that occur with increasing age and poor performance status. On the other hand, it became apparent that the curative potential of transplantation was not solely due to the conditioning regimen but also to the graft-versus-leukemia effect mediated by alloreactive donor T cells. These observations led to the development of new transplant strategies using less intensive preparative regimens that would allows donor cell engraftment without the toxicity of myeloablative conditioning as a method of exploiting a graft-versus-malignancy effect in patients ineligible for conventional marrow grafts. Although follow-up is relatively short, preliminary results are encouraging and demonstrate the feasibility of non-myeloablative transplants in patients with heterogeneous diseases and disease status who received various preparative regiemns. Current challenges include defining the optiaml regimen to promote full donor engraftment and the malignancies susceptible to this approach. The present review summarizes the most recent results obtained in this attractive field.


    1761/2523

    Tytuł oryginału: Atrial fibrillation in the new millennium - the role of pacemaker and defibrillator therapy.
    Autorzy: Mitchell Andrew R. J.
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA233-RA239, il., bibliogr. 62 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Atrial fibrillation is teh most common clinical arrhythmia and with an aging population it is becoming an increasing cause of morbidity and hospitalisation. Antriarrhythmic drug therapy unfortunately remains only moderately effective at preventing recurrences of arrhythmia. Attention has now therefore focused on the development of non-drug techniques to prevent or treat atrial fibrillation in highly symptomatic patients. There are a number of theoretical ways that pacing the atrium may prevent arrhythmias and pacemakers are under investigation for the prevention and termination of atrial arrhythmias with additional tailored, programmable algorithms. The increased memory capacity and diagnostic capabilities of these devices allows the true efficac of pacemaker interventions to be determined. Early results from studies suggest that the implantation of such pacemakers can reduce atrial fibrillation burden and thereby obviate the need for more invasive procedures such as atrioventricular nodal aablation. The improved diagnostics also provides enhanced information about the onset of atrial arrhythmias and suggests that atrial fibrillation may have periods of high organisation and a window for pace termiantion. The atrial defibrillator is a useful, but expensive, therapeutic option in patients with recurrent symptomatic perisitent atrial fibrillation and teh current generation of devices allow patients to activate the device at home using a hand-held activator. This reduces the need for hospitalisation and empowers the aptient to 'take charge' of their condition.


    1762/2523

    Tytuł oryginału: KCNQ1 gene mutations and the respective genotyp-phenotype correlations in the long QT syndrome.
    Autorzy: Herbert Ernest, Trusz-Gluza Maria, Moric Ewa, Śmiłowska-Dzielicka Ewa, Mazurek Urszula, Wilczok Tadeusz
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA240-RA248, il., tab., bibliogr. 62 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: KCNQ1 (formerly called KVLQT1) is a Shaker-like voltage-gated potassium channel gene responsible for teh LQT1 sub-type of LQTS. In general, heterozygous mutations in KCNQ1 cause Romano-Ward syndrome (LQT1 only), while homozygous mutations cause JLNS (LQT1 and deafness). To date, more than 100 families with mutations in this gene have been reported, most with their own novel 'private' mutations. The majority of these mutations are missense. However, other types of mutations, such as deletions, frame-shifts and splice-donor errors have also been reported. There is one frequently reported mutated region (the 'hotspot'). KCNQ1 is now believed to be the most commonly mutated gene in LQTS. The combination of normal and mutan;t KCNQ1 ŕ-subunits has been found to form abnormal I KS channels, hence mutations associated with the KCNQ1 gene are also believed to act mainly through a dominant-negative mechanism (the mutatnt form interferes with the function of the normal wild-type form through a 'poison pill' type mechanism) or loss of function mechanism. Even in the case of carriers of teh same mutaion, it is currently unknown why there are significant clinical phenotype variations in LQT1 patients. This question could be answered by increasing the number of patient genotypes studied. LQT1 patients expereince a majority of their cardiac events (62 p.c.) during exercise, and only 3 p.c. occur during rest or sleep. Of the patients who experienced cardiac events while swimming, 99 p.c. were LQT1. Auditory stimuli are rare and occur in only 2 p.c. of patients. However, both lethal and non-lethal events followthe same pattern.


    1763/2523

    Tytuł oryginału: Reconstructing the cours of HIV-1-associated progressive encephalopathy in children.
    Autorzy: Sanchez-Ramon Silvia, Canto-Nogues Carmen, Munoz-Fernandez M. Angeles
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA249-RA252, il., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • aIDS
  • mikrobiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The factors that trigger the clinical onset of HIV-1-associated progressive encephalopathy (PE) in children remain unknown. HIV-1 invades the central nervous system (CNS) from the very beginning of infection, but the timeframe for PE development is variable. It has recently ben suggested that incrased traffic into the brain of HIV-1-infected or activated moncytes arising directly from the bone marrow may be the first step to clinical onset of adult HIV encephalopathy. The determining factor for this enhanced recruitment of blood monocytes into the CNS in adults has been postulated to be increased HIV-1 replication. However, children usually exhibit high levels of viral load beginning in the first months of life, even under very aggressive antiretroviral therapy. PE inchildren represents a unique form of CNS involvement of HIV, much more common, early, and devastating for children than for adults, representing in fact an independent cause of mortality. In the light of recent literature on this issue and our own in vitro and in vivo results the possible mechanisms implicated in the pathogenesis of PE are descussed. We propose that CD8+ T-lymphocytes would be teh nexus for all the various aspects of teh disease, namely the loss of control over HIV-1 replication, increased traffic of activated monocytes, the spread of infection to immune sanctuaries and finally the neurological emergence of PE. Possible new biologic markers fo neuropathogenesis are suggested.


    1764/2523

    Tytuł oryginału: Journal of Physiology and Pharmacology
    Tytuł angielski: 8th Polish-German Conference on Advances in Experimental and Clinical Pneumology, Warsaw, 9-11 May 2002 - [abstracts].
    Opracowanie edytorskie: Kowalski Janusz (Przedm.), Pokorski Mieczysław (red.), Marczak Magdalena (red.).
    Źródło: J. Physiol. Pharmacol. 2002: 53 suppl. 2 s.3-62, il., tab., bibliogr. [przy ref.] - 8 Polsko-Niemiecka Konferencja pt. Postępy w pulmonologii doświadczalnej i klinicznej Warszawa 09-11.05. 2002
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1765/2523

    Tytuł oryginału: XXII Congress of the Polish Physiological Society, September 4-7th, 2002, Bydgoszcz, Poland - [abstracts].
    Opracowanie edytorskie: Tafil-Klawe Małgorzata (Red.).
    Źródło: J. Physiol. Pharmacol. 2002: 53 suppl. 1 s.3-114 - 22 Kongres Polskiego Towarzystwa Fizjologicznego Bydgoszcz 04-07.09. 2002
    Sygnatura GBL: 302,092

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny

    Temat korporatywny:
  • Polskie Towarzystwo Fizjologiczne


    1766/2523

    Tytuł oryginału: The mechanisms of liver cell death.
    Tytuł polski: Mechanizmy śmierci komórki wątrobowej.
    Autorzy: Kandefer-Szerszeń Martyna, Szuster-Ciesielska Agnieszka, Daniluk Jadwiga, Paduch Roman
    Źródło: Gastroenterol. Pol. 2002: 9 (4) s.265-271, il., bibliogr. 30 poz., streszcz.
    Sygnatura GBL: 313,180

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Apoptoza i nekroza są morfologicznie różniącymi się formami śmierci komórki, które występują w wielu różnych chorobach wątroby. Artykuł ten stanowi przegląd wiedzy dotyczącej morfologicznych i biochemicznych zmian w komórkach ulegających apoptozie oraz mechanizmów regulujących przebieg apoptozy. Omówiono również mechanizmy uczestniczące w generowaniu sygnałów proapoptotycznych wewnątrz komórki pochodzących ze środowiska komórki wątrobowej. Cholangiocyty są nieustannie narażone na działanie czynników genotoksycznych, takich jak sole żółciowe, oraz często na czynniki towarzyszące stanowi zapalnemu. Z kolei indukcja izoenzymu P450 2E1 przez etanol prowadzi do wzrostu wytwarzania rodników tlenowych i peroksydacji lipidów stanowiących sygnał do apoptozy hepatocytów. W wirusowych, autoimmunologicznych i alkoholowych zapaleniach wątroby występuje apoptoza hepatocytów indukowana działaniem cytotoksycznych limfocytów. Także cytokiny, w tym TNF i TGF-á, wiążąc się ze swoistymi receptorami, mogą indukować apoptozę komórek wątrobowych.

    Streszczenie angielskie: Apoptosis and necrosis are morphologically distinct forms of cell death which occur in a wide variety of liver diseases. In this article we review the current knowledge concerning morphological and biochemical changes in cells undergoing apoptosis and intercellular pathways regulating apoptosis. Apoptosis occurs in the cholangiopathies, viral hepatitis and in alcoholic liver diseases. The mechanisms involved in generations of apoptosis signals inside and outside of liver cells are described. Cholangiocytes are continuously exposed to a variety of genotoxic insults, such as chronic inflammation and hydrophobic bile acids. Induction of cytochrome P450 2E1, the alcohol-inducible cytochrome P450, leads to increased release of reactive oxygen species and lipid peroxidation, which in turn may be a signal leading to cell apoptosis. In viral, autoimmune and alcohol-related hepatitis, cytotoxic lymphocyte-mediated pathways of apoptosis are activated. Moreover, cytokines such as tumour necrosis factor (TNF) and tumour growth factor beta (TGF-á) acting through their receptors can induce apoptosis in liver cells.


    1767/2523

    Tytuł oryginału: Morphometric analyses of the muscles of weight-lifters.
    Tytuł polski: Morfometryczna analiza mięśni ciężarowców.
    Autorzy: Cabrić Milan
    Źródło: Med. Sport. 2002: 18 (9) s.397-402, tab., bibliogr. 38 poz., sum.
    Sygnatura GBL: 313,155

    Hasła klasyfikacyjne GBL:
  • medycyna sportowa

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wstęp. Aczkolwiek wielokrotnie wykonano analizy ilościowe zmian występujących w mięśniach szkieletowych po hipertrofii kompensacyjnej, czy spowodowanej wysiłkiem, zarówno u zwierząt, jak i u ludzi, zadziwiająco mało jest dokładnych danych dotyczących kapilarów i jąder mięśniowych ludzkiej tkanki mięśniowej. Celem niniejszego opracowania była analiza kapilar, treści mitochondriów, rozmiarów jąder mięśniowych oraz występujących w nich wzorców chromatyny. Materiał i metody. Próbki tkanki mięśniowej z m. vastus lateralis pobrano metodą biopsji igłowej u pięciu ciężarowców klasy ogólnopolskiej oraz u pięciu osób dobranych pod względem płci i wieku jako grupa kontrolna. Wybrane parametry badano przede wszystkim metodą stereologiczną. Wyniki i wnioski. Stwierdzono różnice pod względem rozmiarów jąder mięśniowych, liczby jąder na danym obszarze, długości jąder, wzorców rozkładu chromatyny oraz objętości frakcji mitochondrialnych we włóknach typu II.

    Streszczenie angielskie: Introduction. Although numerous quantitative analyses have been performed on the changes which occur in skeletal muscles following compensatory or work-induced hypertrophy in both animals and in man, surprisingly little detailed information is available on either muscle capillaries or myonuclear for human muscle. The purpose of this study was to analyze the capillary network, mitochondrial contents, the sizes of myonuclei, and their chromatin patterns. Material and methods. Muscle biopsies were obtained from the vastus lateralis muscles of five national-class weight-lifters, and also from five age-matched control subjects. The selected parameters were measured primarily by stereological techniques. Results and conclusions. Differences were noted in nuclear size, number of nuclei per unit area, length of nuclei, nuclear chromatin patterns, and differences in mitochondrial volume fractions in type II fibres.


    1768/2523

    Tytuł oryginału: Allergic diseases over the world.
    Tytuł polski: Choroby alergiczne na świecie.
    Autorzy: Płusa T[adeusz]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.55-60, il., tab., bibliogr. 24 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Występowanie chorób alergicznych w krajach europejskich zostało przedstawione stosownie do aktualnych danych. W pracy omówiono nowe mianownictwo alergologiczne i najważniejsze czynniki wpływające na występowanie alergii.

    Streszczenie angielskie: The prevalence of allergic diseases IN European countris has been presented according to update studies. The new nomenclature of allergy and the most important factors of allergy have been discussed.


    1769/2523

    Tytuł oryginału: Research progress in acute lung injury and acute respiratory distress syndrome.
    Tytuł polski: Postępy w badaniach nad ostrym uszkodzeniem płuc i ARDS.
    Autorzy: Guisheng Qian
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.61-66, streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • pediatria
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie polskie: Niniejsza praca poglądowa ukazuje rozwój koncepcji ALI/ARDS i przedstawia etiologię, patogenezę, diagnostykę i zasady leczenia ALI/ARDS w oparciu o badania prowadzone w szpitalu w Xinqiao.

    Streszczenie angielskie: This review introduced the advances in concpts of ALI/ARDS and demonstrated etiology, pathogenesis, diagnosis and therapy principles of ALI/ARDS based on the research works in Xinqiao hospital.


    1770/2523

    Tytuł oryginału: á2-adrenoceptor genetic variation and its relation to asthma and allergy.
    Tytuł polski: Genetyczne zróżnicowanie á2-adrenoreceptora i jego odniesienia do astmy i alergii.
    Autorzy: Kowalski M[arek] L., Woszczek G.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.67-70, bibliogr. 33 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wiele badań wskazuje na to, że polimorfizm á2-adrenoreceptora (á2-ADR) może mieć związek nie tylko z astmą. á2-ADR należy do nadrodziny białek receptorowych G. W pracy polimorfizm á2-ADR przedstawiono jako istotny w modulowaniu fenotypu.

    Streszczenie angielskie: Several studies have shown that á2-adrenoceptor (á2-ADR) polymorphisms might be associated not only with asthma. á2-ADR belongs to the superfamily of G protein-coupled receptors. In the paper á2-ADR polymorphisms have been demonstrated to play a potentially important role in the modulation of asthmatic phenotype.


    1771/2523

    Tytuł oryginału: Autoimmunity and allergy - a double-edged sword.
    Tytuł polski: Autoimmunizacja i alergia - miecz o dwóch ostrzach.
    Autorzy: Tchórzewski H.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.71-75, il., bibliogr. 41 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: Komórki dendrytyczne odgrywają kluczową rolę w regulacji odpowiedzi immunologicznej, w której uczestniczą limfocyty T. Specyficzne struktury patogenów rozpoznawane są przez receptory odporności naturalnej, zwane TLR (od ang. toil-like receptor). Pobudzenie TLR2 przez LPS zawierający formę cylindryczną lipidu A, fragmenty komórek nekrotycznych lub histaminę uczynnia dojrzewanie komórek Th1 i reakcje autoimmunizacyjne. Natomiast LPS ze stożkowatą formą lipidu A, utlenione LDL, białka szoku termicznego powodują rozwój komórek Th2, odpowiedzialnych za reakcje alergiczne. Odpowiednia zmiana czynności komórek Th1 lub Th2 stanowić może logiczną przesłankę do rozwoju racjonalnej terapii korekcyjnej.

    Streszczenie angielskie: Dendritic cells (DC) play a decisive role in the control of T cell-mediated immune response, recognise pathogen associated molecular pattem (PAMP) by specific receptors called toll-like (TLR). Inflammatory molecules regulate (TLR2 and TLR4 expression with cylindrical from of lipid A, necrotic cells or peptidoglycans, histamine active TLR2 signaling pathway and Th1 development responsible for autoimmunity. On the other side LPS with conical form of lipid A, oxidized LDL or heat shock proteins (HSP) activate TLR4 pathway and Th2 maturation involved in allergy. Modification of Th1 or Th2 functional response creates the rationale basis for future therapy.


    1772/2523

    Tytuł oryginału: Mediators of inflammation in asthma.
    Tytuł polski: Mediatory zapalenia u chorych na astmę oskrzelową.
    Autorzy: Jahnz-Różyk K[arina]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.76-80, il., bibliogr. 36 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W patologii schorzeń atopowych istotną rolę odgrywają komórki immunologicznie czynne, które wytwarzają m.in. cytokiny, leukotrieny, toksyczne białka eozynofilowe. W pracy przedstawiono krótką charakterystykę mediatorów zapalenia alergicznego u chorych na astmę.

    Streszczenie angielskie: Many cells and their products: cytokines, leukotrienes, eosinophil secondary granule proteins are important contributes to the pathology of atopic airway disease. This study provides a brief status report regarding mediators in allergic inflammation of asthmatic patients.


    1773/2523

    Tytuł oryginału: Nasal provocation test in diagnosis of occupational allergy.
    Tytuł polski: Testy prowokacyjne w diagnostyce alergii zawodowej.
    Autorzy: Górski P.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.81-86, tab., bibliogr. 27 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy przedstawiono rolę testów prowokacji donosowej w rozpoznawaniu alergii zawodowej. W materiale z płukania nosa oceniano stężenie eozynofilowego białka kationowego (EPC) i tryptazy komórki tucznej (MCT) po prowokacji aldehydem glutarowym. Wykazano, że zmiany w cytologii, w stężeniach mediatorów w materiale z płukania nosa oraz w spirometrii pozwalają na rozpoznanie alergicznego zapalenia błony śluzowej nosa i astmy spowodowanej aldehydem glutarowym.

    Streszczenie angielskie: The role of nasal provocation tests in diagnosis of occupational allergy was presented in this study. The concentrations of eosinophil cationic protein (ECP) and mast cell tryptase (MCT) in nasal lavage fluid after exposure to glutar-aldehyde were evaluated. The results of the study showed that changes in cytology and mediators of inflammation in nasal fluid in coincidence with spirometry changes could identify patients with occupational asthma and rhinitis.


    1774/2523

    Tytuł oryginału: Tripholide induced apoptosis of eosinophils in airways of allergic guinea pigs.
    Tytuł polski: Apoptoza eozynofilów oddechowych świnek morskich pod wpływem trifolidu.
    Autorzy: Changzheng Wang, Kefang Lai, Xiaoming Guo
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.87-89, il., bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie

    Streszczenie polskie: W pracy badano wpływ wyciągu z trifolidu z chińskich ziół na apoptozę granulocytów kwasochłonnych u świnek morskich z alergią. Wykazano, że trifolid hamuje apoptozę granulocytów kwasochłonnych i ekspresję bcl-2 w granulocytach kwasochłonnych z dróg oddechowych świnek morskich oraz że może być pomocny w leczeniu zapalenia dróg oddechowych w chorobach alergicznych, takich jak astma.

    Streszczenie angielskie: In this study, the effects of tripholide extract from a Chinese herb on eosinophilic apoptosis in allergic guinea pigs was explored. The findings showed that tripholide could inhibit eosinophilic apoptosis and the expression of bcl-2 in eosinophils from allergic guinea pigs' airways and would be of help for treatment of airway inflammation in allergic diseases such as asthma.


    1775/2523

    Tytuł oryginału: Pollen calendar.
    Tytuł polski: Kalendarz pyleń.
    Autorzy: Buczyłko K., Wagner A.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.90-97, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Kalendarz pyleń stanowi bardzo użyteczne narzędzie w alergologii. Przedstawiono niektóre praktyczne aspekty, zgodnie aktualnymi danymi, z uwzględnieniem sytuacji w poszczególnych regionach świata.

    Streszczenie angielskie: Pollen calendar is the very usefull tool in allergology. Some practical aspects have been presented according to actual data and to situation in the world regions.


    1776/2523

    Tytuł oryginału: Occupational allergy due to natural rubber latex in health care workers.
    Tytuł polski: Zawodowa alergia na lateks gumy naturalnej u pracowników ochrony zdrowia.
    Autorzy: Pałczyński C[ezary]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.98-101, bibliogr. 21 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W okresie ostatnich 12 lat zawodowa alergia natychmiastowa na lateks gumy naturalnej, występująca głównie u pracowników służby zdrowia, stała się problemem zdrowia publicznego w krajach rozwiniętych. W artykule omówiono aktualny stan wiedzy dotyczącej tej alergii, z uwzględnieniem definicji, danych epidemiologicznych, objawów klinicznych, reakcji nadwrażliwości krzyżowej diagnostyki i zasad prewencji.

    Streszczenie angielskie: During the past twelve years, IgE-mediated allergy to natural rubber latex (NRL) has become a public health problem in industrialised countries. This article briefly reviews current knowledge concerning NRL allergy among health care workers, including definitions, epidemiological data, clinical symptoms, cross-reactions, diagnostic procedures and preventive measures.


    1777/2523

    Tytuł oryginału: Bacteria and viruses in allergic diseases.
    Tytuł polski: Bakterie i wirusy w chorobach alergicznych.
    Autorzy: Carewicz R[omuald], Chciałowski A.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.102, 104-108, il., tab., bibliogr. 62 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Bakteryjne i wirusowe zakażenia układu oddechowego są, obok ekspozycji na alergen, najczęstszymi czynnikami wywołującymi zaostrzenia alergicznych chorób dróg oddechowych. Kwestia, czy zakażenia odgrywają ochronną czy szkodliwą rolę w chorobach atopowych i alergicznych w odniesieniu do procesu ich powstawania i stopnia ciężkości, wymaga dalszych i mocniejszych dowodów. Istniejące dane nie mogą zapewnić prostego rozwiązania tego problemu. Wiele niezależnych obserwacji sugeruje, że infekcje wirusowe i bakteryjne mogą prowadzić do dwojakich efektów dotyczących atopii i alergii. Wskazują one, że stymulacja układu odpornościowego antygenami lub drobnoustrojami, prawdopodobnie zależna od czasu (lub drogi, dawki i rodzaju bodźca), może wpływać na rozwój chorób atopowych, zapobiegając lub sprawiając ich ujawnienie się. Dane inspirowane przez tzw. hipotezę higieniczną sugerują korzystną rolę zakażeń we wczesnym dzieciństwie lub złych (czy raczej naturalnych) warunków higienicznych wskutek ich wpływu na dojrzewający układ odpornościowy, zwłaszcza na pożądaną równowagę Th1/Th2 w kierunku pierwszego rodzaju odpowiedzi. Prawdopodobnie działają one w ten sposób, gdy infekcja lub naturalna ekspozycja na drobnoustrój poprzedza ekspozycję na antygen u osób wrażliwych. Inne badania wykazują przeciwny wpływ bakterii i wirusów na drogi oddechowe, wykazujące przewlekły proces zapalny i zwiększoną nadwrażliwość. Niniejsza praca poglądowa wskazuje na kilka szczegółowych mechanizmów ...

    Streszczenie angielskie: Bacterial and viral respiratory infections, apart from allergen exposure, are known to be the most common factors trigering exacerbation of allergic airways conditions. The question if the infections play a protective or harmful role in atopy and allergic diseases regarding to the process of their development and the grade of severity still needs further and stronger evidences. Existing data cannot provide a simple resolution of the problem. Many independent observations suggest that viral and bacterial infections may lead to dual effects pertaining to atopy and allergy. They indicate that antigen or microbial stimulation of immune system probably depending on timing (or a route, dosage and stimulus type) can affect the development at atopic disorders either preventing or promoting their manifestation. The data inspired by so called "hygienic hypothesis" suggest beneficial role of early childchood infections or poor (or rather natural) hygiene conditions through their influence on maturing immune system, especially on desired Th1/Th2 balance towards the first response. They act so probably when infection or natural microbial exposure precedes antigen exposure in sensitive subjects. Other studies show opposite effects of bacteria and viruses on the airways, demonstrating prolonged inflammatory process and increased hyperresposiveness. This review indicates some detailed potential mechanisms of infections involved in inflammatory process modulation with respected to ...


    1778/2523

    Tytuł oryginału: Prions in medicine.
    Tytuł polski: Priony w medycynie.
    Autorzy: Denys A[ndrzej], Denys P., Żołyński A., Cieślik P.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.109-111, bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie polskie: Priony stały się ważnym tematem w związku z przypadkami przeniesienia encefalopatii gąbczastej bydła na ludzi. Artykuł prezentuje podstawy molekularne procesu tworzenia białek PrP**c oraz powstawania ich form izometrycznych, rolę bariery gatunkowej i jej przełamywania w procesie zakażenia, a także opracowania dotyczące metod rozpoznawania pasażowalnych amyloidaz mózgowych. W podsumowaniu zwrócono uwagę na aspekty praktyczne, tj. zagadnienia profilaktyki i inaktywacji prionów.

    Streszczenie angielskie: New variant of Creutzfeldt-Jakob disease has become a vital problem due to some cases of bovine spongiform encephalopathy transmission to human. Molecular basis of production of PrP**c proteins, their isomeric form creation, the role of species barrier and its overcoming in the infection process, methods of transmissible brain amyloidosis diagnosis have been presented in the paper.


    1779/2523

    Tytuł oryginału: Similarities between bronchial asthma and allergic rhinitis.
    Tytuł polski: Podobieństwa pomiędzy astmą oskrzelową i alergicznym zapaleniem błony śluzowej nosa.
    Autorzy: Ligęziński A[leksander]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.112-116, bibliogr. 30 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W ciągu ostatnich lat coraz częściej i dobitniej podkreśla się wzajemne zależności między zapalnymi chorobami górnych dróg oddechowych a, przede wszystkim, astmą oskrzelową. Całoroczne i sezonowe zapalenie błony śluzowej nosa, przewlekłe zapalenie zatok przynosowych i błony śluzowej nosa należą do schorzeń, których na rozwój i przebieg astmy oskrzelowej jest powszechnie znany i akceptowany. Przyjmuje się jednak, że całoroczne alergiczne zapalenie błony śluzowej nosa częściej współwystępuje z astmą niż zapalenie sezonowe. Częste współistnienie tych schorzeń wynika z potwierdzonych wielu podobieństw, ale również i różnic anatomicznych i fizjopatologicznych między górnym i dolnym odcinkiem dróg oddechowych. Z badań przeprowadzonych przez różnych autorów wynika, że większość z nich jest zdania, iż u osób młodych (59-85 proc.) alergiczne zapalenie błony śluzowej nosa poprzedzało wystąpienie astmy oskrzelowej lub oba schorzenia występowały równocześnie.

    Streszczenie angielskie: In recent years ever more frequently and emphatically the mutual relationship has been stressed between inflammatory diseases of the upper and lower airways and in the first place, bronchial asthma. Perennial and seasonal rhinitis, chronic rhinosinusitis belong to diseases, the effect of which is widely known and accepted on the development and course of bronchial asthma. It is assumed, however, that perennial allergic rhinitis coexists more frequently with bronchial asthma than seasonal rhinitis. Frequent coexistence of these diseases results from confirmed numerous anatomical and pathophysiological similarities but also differences between the upper and lower segments of the airways. The studies performed by various authors indicate that most of them share the opinionthink that in young persons (59-85 p.c.), alergic rhinitis preceded the development of bronchial asthma or both diseases developed simultaneously.


    1780/2523

    Tytuł oryginału: Infections and bronchial hyperreactivity.
    Tytuł polski: Zakażenia a nadreaktywność oskrzeli.
    Autorzy: Siergiejko Z[enon]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.117-118, 120-122, bibliogr. 29 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Nadreaktywność oskrzeli jest cechą charakterystyczną wielu zapalnych chorób układu oddechowego. Najbardziej charakterystyczna jest jednak dla astmy oskrzelowej przewlekłej. Badania kliniczne wykazały, że zakażenia dróg oddechowych indukują nadreaktywność oskrzeli, a także zaostrzają przebieg astmy. Wśród patogenów wymienia się najczęściej wirusy (RSV, rynowirusy, koronawirusy) oraz bakterie (Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia trachomatis). Ostatnio wykazano wzmożoną nadreaktywność oskrzeli zakażonych HIV. Spośród grzybów Aspergillus fumigatus jest tym, który powoduje alergiczne zapalenie pęcherzyków płucnych i może wywoływać nadreaktywność oskrzeli. Inne grzyby z grupy Alternaria, Cladosporium i Penicillium odgrywają istotną rolę w wywoływaniu astmy, chociaż nie jest to spowodowane zakażeniem górnych dróg oddechowych. Istotną rolę w nadreaktywności odgrywają też pasożyty.

    Streszczenie angielskie: Bronchial hyperreactivity lung diseases. The most intensive BHR can be observed in patients suffering from chronic asthma. Numerous clinical observations suggest that airway infections can induce bronchial hyperreactivity in susceptible patients, and extracerbate bronchial asthma. The most important role is played by viral infections (RSV, Rhinoviruses, Coronaviruses) and chronic bacterial infections (Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia trachomatis). Recently some authors have reported an increased appearance of BHR in HIV-infected patients. Among moulds Aspergillus, which causes hypersensitivity pneumonitis, can induce BHR. Though many moild allergens such as Alternaria, Cladosporinum and Penicilium can play an important role in the induction of asthma and BHR, the do not cause airway infection. Numerous parasites are responsible for asthma and BHR induction, but they rarely cause airway infection.


    1781/2523

    Tytuł oryginału: Thermography usefulness in infection and allergy.
    Tytuł polski: Przydatność termografii w zakażeniach i alergii.
    Autorzy: Jung A[nna], Żuber J., Kalicki B.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.123-129, il., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia
  • otorynolaryngologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Postęp w naukach podstawowych stwarza medycynie klinicznej możliwość stosowania nowych technologii w celach diagnostycznych lub terapeutycznych. Szerokie zastosowanie termografii w diagnostyce medycznej jest spowodowane głównie jej nieinwazyjnością. Termografia umożliwia określenie miejsca i ocenę charakteru u rozległości procesów zapalnych. Autorzy udokumentowali wiele przypadków klinicznych, rozpoznanych z powodzeniem w klinice pneumonologii, alergologii i innych.

    Streszczenie angielskie: Progress in basic sciences gives clinical medicine an opportunity to apply new technologies for diagnostic or therapeutic purposes. A wide application of thermography in medical diagnostics is caused primarily by its non-invasiveness. Thermography is able to determine the location and evaluate the charcter and size of inflammatory processes. The authors documented many clinical cases that were successfully diagnosed in pneumology, allergology and other departments.


    1782/2523

    Tytuł oryginału: GINA 2002 - differences from GINA 1995.
    Tytuł polski: Raport GINA 2002 - różnice w stosunku do GINA 1995.
    Autorzy: Małolepszy J., Fal A[ndrzej] M.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.130-134, bibliogr. 30 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W ciągu ostatnich trzech dekad astma oskrzelowa stała się istotnym problemem zdrowotnym w większości krajów rozwiniętych świata. W uznaniu tego faktu, w roku 1993 National Hearth, Lung and Blood Institute we współpracy ze Światową Organizacją Zdrowia powołał komisję, której raport Globalna Strategia Leczenia i Prewencji Astmy stanowi wytyczne dla leczenia i prewencji tej choroby. Dodatkowym działaniem było powołanie grupy ekspertów pod nazwą Globalna Inicjatywa dla Astmy (Global Initiative for Asthma, GINA), której zadaniem jest monitorowanie i uaktualnienie bieżących trendów dotyczących terapii i prewencji astmy oskrzelowej. Efektem pracy tej grupy jest m.in. opublikowany w 2002 raport, znany pod nazwą GINA 2002, będący uaktualnieniem Globalnej Strategii z 1995 r. Zgodnie z danymi zebranymi w ostatnich latach, zaprezentowano m.in. nową grupę leków beta-adrenergicznych - leki szybko działające. Zwrócono także uwagę, dużo większą niż dotychczas, na współpracę lekarz-pacjent, podano szczegółową koncepcję planowania leczenia każdej postaci astmy oraz wskazano prostszy, aczkolwiek oparty na tym samym parametrze (PEF) system monitorowania ciężkości przebiegu choroby i poprawności leczenia.

    Streszczenie angielskie: In the past three decades asthma became a serious public health problem in countries throughout the world. This chronic condition affects people pf all ages in countries throughout the world. In recognition of this fact in 1993 National Heart, Lung and Blood Institute in collaboration with the World Health Organization carried out a workshop that prodused a final documented published in 1995. Global Strategy for Asthma Management and Prevention that presented a comprehensive plan to affectively manage asthma in order to reduce chronic disability and premature deaths while allowing patients with asthma to lead productive lives. Another program called the Global Initiative for Asthma (GINA) was implemented. Its goals were outlined in the Global Strategy for Asthma Management and Prevention. Since then GINA distributed world wide three major publications. Asthma Management and Prevention. A Practical Guide for Public Health Officials and Health Care Professionals, Pocket Guide for Asthma Management and Prevention, and What You and Your Family Can Do About Asthma. They were translated into several languages and helped this way to introduce unified asthma definition, diagnosis and treatment throughout the world. In 2002, as recognition of further development in asthma understanding a document called GINA 2002 has been presented. It offers a modified approach to asthma including some changes on asthma definition as well as changes in treatment strategy. The last ones cover a new group of beta two agonists, i.e. fast acting drugs together with a modified approach to chronic treatment...


    1783/2523

    Tytuł oryginału: Synergic therapy in bronchial asthma.
    Tytuł polski: Leczenie synergistyczne w astmie oskrzelowej.
    Autorzy: Kuna P[iotr]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.136-140, tab., bibliogr. 33 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Glikokortykosteroidy stosuje się w leczeniu stanu zapalnego dróg oddechowych w astmie. Leki á2-mimetyczne o przedłużonym działaniu zapobiegają i odwracają skurcz oskrzeli. Obie grupy leków działają komplementarnie, a tym samym wpływają leczniczo na dwie komponenty patogenetyczne astmy oskrzelowej. Synergia działania glikokortkosteroidów i długo działających á2-mimetyków powoduje, że takie leczenie jest bardziej skuteczne niż podwojenie dawki GCS. Badania kliniczne wykazały, że łączenie leków wziewnych w jednym inhalatorze, np. Symbicartu (budezonid + firmoterol) lub Seretidu (flutikazon + salmeterol) jest co najmniej tak samo efektywne, dobrze tolerowane i bezpieczne, jak podawanie każdego leku w oddzielny inhalatorze Symbicort jest zalecany także do doraźnego odwracania skurczu oskrzeli ze względu na szybkie działanie bronchodylatacyjne formoterolu.

    Streszczenie angielskie: Corticosteroids treat the underlying airway inflammation in asthma; long-acting á2-agonists prevent and reverse airway obstruction. Thus, corticosteroids and long-acting á2-agonists exert complementary effects, treating two different components of asthma. Clinical studies show that in the treatment of asthma, the combination of glucocorticosteroids with long-acting á2-agonist is more effective than double dose GCS, due to their-synergy. It is already well documented that combination therapy in asthma with drugs such as symbicort (budesonide plus formoterol) or Seretide (fluticasone plus salmeterol) is at least as effective, well tolerated and safe as its mono-products in corresponding doses given via separate inhalers. More convenient treatment represents an important benefit for patients with asthma. Symbicort is recommended for regular treatment and could also be used "as needed" due to the rapid onset of the bronchodilatatory effect of formoterol.


    1784/2523

    Tytuł oryginału: The effect of Tripholide on airway responsiveness for guinea pig asthma models: the role of hypodense eosinophils.
    Tytuł polski: Wpływ trifolidu na reaktywność dróg oddechowych w astmie u świnek morskich: rola eozynofilów hipodensyjnych.
    Autorzy: Changzheng Wang, Xiangjian Guo
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.141-143, tab., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie

    Streszczenie polskie: Opracowano model astmy u świnki morskiej z zastosowaniem albuminy jaja kurzego w aerozolu. Grupę świnek morskich chorych na astmę leczono trifolidem. Stwierdzono, że reaktywność dróg oddechowych na histaminę była znacznie większa w grupie astmy niż w grupie kontrolnej. Całkowita liczba komórek, bezwzględna liczba granulocytów kwasochłonnych, odsetek hipodensyjnych granulocytów kwasochłonnych i poziomy aktywności zwiększającej żywotność granulocytów kwasochłonnych (EVEA) w popłuczynach oskrzelowo-pęcherzykowych (BALF) były znacznie wyższe w grupie astmy niż u zwierząt kontrolnych. Odsetek hipodensyjnych granulocytów kwasochłonnych i liczba granulocytów kwasochłonnych ściśle korelowały z reaktywnością dróg oddechowych (r= -0.76 i 0.88, P = 0.05 i 0.01, odpowiednio). Leczenie świnek morskich chorych na stmę trifolidem znacznie zmniejszyło reaktywność dróg oddechowych i obniżyło odsetek hipodensyjnych granulocytów kwasochłonnych oraz poziom EVEA, ale nie miało wpływu na stężenie eozynofilów w BALF. Wyciągnięto wniosek, że trifolid zmniejsza reaktywność dróg oddechowych w astmie poprzez zmniejszenie liczby aktywnych hipodensyjnych granulocytów kwasochłonnych.

    Streszczenie angielskie: Guines pig model of asthma was established with aerosolized ovalbumin. A group of asthmatic guinea pigs were treated with tripholide. It was found that the airway responsiveness to histamine was markedly higher in asthma group than in the control. The total cell count, absolute eosinophil count, percentage of hypodense eosinophils and the levels of eosinophil viability enhancing activity (EVEA) in the bronchoaleolar lavage fluid (BALF) were significantly higher in asthmatic group than in the control. The percentage of hypodense eosinophils and number of eosinophilsa were in close correlation with airway responsiveness (r = -0.76 and -0.88, P,0.05 and 0.01 respectively). The treatment of the asthmatic guinea pigs with tripholide significantly reduced the airway responsiveness and decreased the percentage of hypodense eosinophils and the level of EVEA but eosinophilia in BALF was not affected. It was concluded that tripholide exercises its effects to decrease airway responsiveness in asthma through its action to reduce active hypodense eosinophils.


    1785/2523

    Tytuł oryginału: Education: "An essential part of the management of asthma".
    Tytuł polski: Edukacja: "Istotna część postępowania w astmie".
    Autorzy: Droszcz W., Droszcz P.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.144-146, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Autorzy przedstawili różne problemy związane z edukacją w astmie, które od lat 80. stopniowo stają się bardzo ważne w postępowaniu w tej chorobie i uzyskały wysoką ocenę (poziom I-A w medycynie opartej na dowodach). W drugiej części artykułu przedstawili własny system edukacji w astmie, stosowany w Szkole dla Chorych na Astmę w Warszawie.

    Streszczenie angielskie: The authors discussed various problems connected with asthma education which since 1980s gradually became very important in asthma management, reaching high level of appreciation (Level I-A in evidence based medicine). In the second part of the paper, they presented their own system of asthma education which they are conducting in Warsaw Asthma School.


    1786/2523

    Tytuł oryginału: Progress in allergen-specific immunotherapy.
    Tytuł polski: Postępy w immunoterapii alergenowo-swoistej.
    Autorzy: Płusa T[adeusz]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.148-151, tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Immunoterapia alergenowo-swoista (SIT) stanowi narzędzie umożliwiające kontrolowanie chorób alergicznych. Miejsce tej metody leczenia przedstawiono stosownie do międzynarodowych zaleceń i dostępnych obserwacji klinicznych. Nowe strategie stosowania SIT są dyskutowane w odniesieniu do współczesnych możliwości medycyny. Rozważania dotyczące wskazań do SIT zestawiono z uwzględnieniem zaleceń międzynarodowych.

    Streszczenie angielskie: Allergen-specific immunotherapy (SIT) is considered a tool for control od allergic diseases. The current position of SIT has been presented according to international guidelines and obtained clinical observations. The new strategies of SIT have been discussed in relation to contemporary possibilities of clinical medicine. The consideration for indications to SIT have been summarised according to international recommendations.


    1787/2523

    Tytuł oryginału: Immunodeficiency syndromes with excessive production of immunoglobulin E.
    Tytuł polski: Pierwotne niedobory odporności z nadmiernym wytwarzaniem IgE.
    Autorzy: Zeman K[rzysztof]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.152-155, bibliogr. 23 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pierwotnych niedoborach odporności dochodzi do zaburzenia funkcjonowania komórkowych i/lub humoralnych elementów układu odpornościowego. Zespół Omenna i zespół hiper-IgE są pierwotnymi zaburzeniami odporności, w których paradoksalnie dochodzi do wzmożonego wytwarzania IgE. Zespół Omenna jest złożonym nidoborem odporności charakteryzującym się brakiem limfocytów B, skojarzonym z uogólnioną erytrodermią, powiększeniem węzłów chłonnych, wątroby i śledziony, eozynofilią zwiększonymi wartościami IgE oraz zaburzeniami aktywacji limfocytów T. Objawy kliniczne wynikają z mutacji genów niezbędnych w procsach rearanżacji genów dla receptora TCR limfocytów i genów immunoglobulinowych. Zespół hiper-IgE jest pierwotnym niedoborem odporności charakteryzującym się nawracającymi ropniami skóry i płuc, zapaleniami płuc, przewlekłym wypryskiem oraz bardzo dużymi stężeniami IgE. Istotną rolę w patogenezie nieprawidłowości immunologicznych obserwowanych w tym zespole wydaje się odgrywać zaburzenie balansu limfocytów Th1/Th2 i zmniejszenie wytwarzania IFN-ç.

    Streszczenie angielskie: Primary immunodeficiency disorders may affect one or more components of the immune system, including T, B, and natural killer lymphocytes, phagocytic cells, and complemented proteis. Omenn and hyper-IgE syndromes are the immunodeficiency disorders also characterized by excessive production of immunoglobulin E antibodies. The Omenn syndrome is a peculiar, autosomal recessive severe combined immunodeficiency (SCID) characterised by absence of B cells, associated with early-onset, generalised, exudative erythrodermia, lymphoadenopathy, hepato- and splenomegaly, hypererosinophilia, elevated srum IgE: and normal to highly activated, yet non-functional, oligoclonal T cells. The Omenn syndrome is an unusual severe immunodeficiency, and its features are due to a defect in Rag-1 or Rag-2 genes. The hyper-IgE syndrome, a rare immunodeficiency, is chracterised by recurrent skin and pulmonary abscesses, pneumonia with formation of pneumatoceles, recurrent eczematoid rashes, as well as extreme elevations in serum IgE levels. Th1/Th2 imbalance and decreased IFN-ç productionn may be of key importance in the pathogenesis of the immune abnormalities of hyper-IgE syndrome.


    1788/2523

    Tytuł oryginału: Antieosinophilic effect of IL-12 and IL-18.
    Tytuł polski: Przeciwoezynofilowy efekt IL-12 i IL-18.
    Autorzy: Fal A. M.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.156-160, bibliogr. 25 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • farmacja
  • otorynolaryngologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Eozynofilia tkankowa jest ważnym elementem patomorfologicznym w zapaleniu alergicznym. Poza tym eozynofile odgrywają istotną rolę m.in. w patogenezie polipów nosa. Wielkość eozynofilii tkankowej jest regulowana przede wszystkim przez wybiórczą ich migrację z naczyń krwionośnych wbrew gradientowi stężeń niektórych cytokin dzięki interakcji VCAM-1/VLA-4, a także poprzez wzmożoną ich produkcję i dojrzewanie w szpiku kostym oraz opoźnienie apoptozy w tkankach obwodowych. Interleukina 12 jest pleiotropową cytokiną aktywną w licznych procesach immunologicznych i zapalnych. Wykazano w modelu zwierzęcym jej udział w indukowaniu i regulowaniu odpowiedzi typu Th1 na liczne patogeny wewnątrzkomórkowe. IL-12 i IL-18 zmniejszają także natężenie zapalenia alergicznego w modelu zwierzęcym. Poprzez nasilenie produkcji IFN-gamma powodują zmianę równowagi pomiędzy klonami Th1 i Th2 na korzyść tych pierwszych. Obserwowany w wielu badaniach in vitro synergizm takiego działania może sugerować działanie podobnego mechanizmu in vivo. Kluczową rolę w regulacji przeżycia eozynofila w tkance obwodowej przypisuje się cytokinom produkowanym przede wszystkim przez komórki Th2 - IL-3, IL-5, GM-CSF. Wykazano już poprzednio, że IL-12 zmniejsza eozynofilię tkankową w modelu zwierzęcym, a Hofstra i wsp. dodatkowo wykazali, że IL-18 wspólnie z IL-12 zapobiega indukowanemu alergenem wzrostowi nadreaktywności oskrzeli, eozynofilii BAL oraz wzrostowi poziomu IgE w surowicy krwi i rozwojowi ...

    Streszczenie angielskie: The dominance ofcosinophil-rich infiltrates within the affected tissues is one of the histological hallmarks in allergic diseases. Eosinophils are also recognized to be important effector of the pathophysiology of allergies, nasal polyps and numerous other conditions including parasite infection. Evidence exists that one of the major mechanisms linderlying eosinophii accumulation affected tissaes involves the selective expression of cndothehal adhesion molecule (VCAM-1) and irs counterligand - very late activation antiger -4(VLA-4). Rxtended eosinophil survival in the tissue, their migration against concentration gradients of several cytokines, as well as increased prodliclion and maturation in the bone marrow seem also to play an important role. IL-12 and 18 are pleiotropic cytokines known, amongst athers, to suppres allergic inflammation in animal models. By enhancing IFNç production, both IL-18 and IL-2 exert regulatory effects on T-cells, including a shift in the balance of T-cells away from TH2 and downregulation of IgE syntheis. Several studies have also found a synergy between IL-18 and IL-12 in regulation of IFNç production and other effects in vitro suggesting a possible synergy in vivo as far as anti-allergic effect is concerned. IL-5, IL-3 and GM-CSF are mainly TH2-originating cytokines capable of enhancing eosinophil survival. However, for eosinophil survival in tissue it is important that may become an autocrine source of GM-CSF (and possibly IL-5). In ...


    1789/2523

    Tytuł oryginału: Respiratory allergy and inflammation due to ambient particulate - a European-wide assessment (RAIAP) - Polish experience.
    Tytuł polski: Procesy alergiczne i zapalne wywołane działaniem pyłów środowiskowych - europejskie badania przekrojowe (RAIAP) - doświadczenia własne.
    Autorzy: Rydzyński K[onrad], Hałatek T., Stępnik M., Tarkowski M.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.161-166, il., tab., bibliogr. 19 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Występowanie astmy u dzieci i młodzieży w ciągu ostatnich dwudziesięcioleci w wielu uprzemysłowionych krajach powiększyło się trzy lub czterokrotnie. Powszechność występowania astmy w krajach wysoko uprzemysłowionych kontrastuje z mniejszą częstością ujawnianą w krajach o niższym standardzie. Wpływ czynników środowiskowych w chorobach o podłożu alergicznym jest wielce prawdopodobny. W wykonywanej w projekcie RAIAP weryfikacji toksyczności pyłów środowiskowych pyły zebrane na różnych stanowiskach europejskich (Oslo, Rzym, Bilthoven, Łódź), wykazujące prozapalne działanie w badaniach in vitro, poddane zostaną badaniom in vivo na szczurach. W pracy zaprezentowano wstępne badania in vivo przeprowadzone w celu validacji i uzyskania danych referencyjnych po dotchawiczej instalacji zawiesiny małych dawek pyłów standardowych PM10.

    Streszczenie angielskie: The prevalence of asthma in children and young adults has tripled and quadrupled in many industrialised countries during the last two decades. However, the prevalence of allergic disease in highly industrialized regions contrasts to rates in countries with lower living standards. Environmental influence on the expression of allergic diseases is very likely. In order to verify the toxicity of ambient particulate material which has been identified to show airway inflammation potential in the in vitro screening RAIAP studies, samples collected in different European location (Oslo, Rzym, Bilthoven, Łódź) will be examined in an in vivo animal model. In preliminary in vivo studies performed to validate the system and obtain the refernce data the inflammatory effects were determined using the technique of intratracheal instillation of small samples of resuspended standards PM 10 particulates.


    1790/2523

    Tytuł oryginału: Radioisotope imaging diagnosis of pulmonary diseases of allergic origin.
    Tytuł polski: Radioizotopowa diagnostyka obrazowa chorób płuc o podłożu alergicznym.
    Autorzy: Dziuk E[ugeniusz]
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (2) s.167-173, il., tab., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy przedstawiono metody scyntygrafii perfuzyjnej, wentylacyjnej i aerozolowej wykorzystywane w diagnostyce chorób układu oddechowego. Omówiono stosowane radiofarmaceutyki oraz metody badania. Szczególną uwagę zwrócono na radioizotopową diagnostykę zatoru płucnego. Znajomość kryteriów rozpoznawania tego groźnego powikłania jest konieczna przy rozpatrywaniu zmian patofizjologicznych w płucach o podłożu alergicznym. Przedstawiono stwierdzenie w astmie oskrzelowej zaburzenia perfuzji i wentylacji, które można rozpoznawać metodami radioizotopowymi i różnicowanie z zatorem płucnym. Omówiono także zmiany w wentylacji i perfuzji obserwowane w przewlekłej obturacyjnej chorobie płuc oraz możliwość oceny wpływu leków rozszerzających oskrzela na poprawę wentylacji płuc. Badania radioizotopowe wentylacji i perfuzji płuc są czułymi metodami rozpoznawania chorób układu oddechowego o podłożu alergicznym. Metody te obrazują zarówno regionalnie, jak i globalnie zaburzenia wentylacji i perfuzji, a także pozwalają ocenić przebieg choroby oraz efekt stosowania leczenia.

    Streszczenie angielskie: In the paper the methods are presented of perfusion, ventilation and aerosol scintigraphy used in the diagnosis of respiratory system diseases. The applied radiopharmaceuticals and study methods are discussed. Particular attention is paid to radioisotope duagnosis of pulmonary embolism. The knowledge of the diagnostic criteria of this dangerous complication is necessary when considering pathophysiological pulmonary changes of allergic origin. Perfusion and ventilation disturbances found in bronchial asthma are presented, which can be diagnosed by radioisotope methods and differentiated from pulmonary embolism. Also ventilation and perfusion changes, observed in chronic obturatory lung disease and the possibility of assessment of bronchodilating drug effect on pulmonary ventilation improvement are discussed. Radioisotope lung ventilation and perfusion tests are sensitive methods of diagnosis of respiratory system diseases of allergic background. These methods visualise both regional and global ventilation and perfusion disturbances and also make possible to assess the disease course and the effect of administered tretment.


    1791/2523

    Tytuł oryginału: Genetic basis of neural tube defects. [P]. 2: Genes correlated with folate and methionine metabolism.
    Autorzy: Gos Monika, Szpecht-Potocka Agnieszka
    Źródło: J. Appl. Genet. 2002: 43 (4) s.511-524, il., bibliogr. s. 522-524
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Effective supplementation with folate, which prevents neural tube defect (NTD) occurrence, and high homocysteine levels in the blood of NTD children's mothers suggest that genes involved in folate and homocysteine metabolizm can be involved in NTD aetiology. Genes encoding methylenetetrahydrofolate reductase (MTHFR) or methylenetetrahydrofolate dehydrogenase (MTHFD) belong to the first group. Genes encoding methionine synthase (MTR), its regulator - methionine synthase reductase (MTRR) and also cystathionine synthase (CBS) can be included in the second grop. We present a current list of the folate and homocysteine metabolism genes that are known to be involved in NTD and pay special attention to primary and secondary NTD prevention.


    1792/2523

    Tytuł oryginału: Journal of Applied Genetics
    Tytuł polski: Opposite responses in two DNA repair capacity tests in lymphocytes of head and neck cancer patients.
    Autorzy: Sąsiadek Maria, Schlade-Bartusiak Kamila, Zych Monika, Noga Leszek, Czemarmazowicz Halina
    Źródło: J. Appl. Genet. 2002: 43 (4) s.525-534, tab., bibliogr. s. 532-534
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Genomic instability has long been recognized as the main feature of neoplasia and a factor modulating individual cancer susceptibility. There are attempts to find effective assays of both individual DNA repair capacity and genetic instability, and their relation to the cancer risk. Genetic predisposition plays an important role in the etiology and development of head and neck squamous cell carcinoma (HNSCC). The aim of our study was to search for a correlation between chromosomal instability and DNA repair capacity in HNSCC patients and healthy controls. The chromosomal instability was measured by the number of bleomycin (BLM)-induced chromosomal aberrations and diepoxybutane (DEB)-induced sister chromatid exchanges. The DNA reapir capacity was assessed using the DEB-induced adaptive response (AR). The HNSCC patients in our study showed a significant increase in chromosomal instability after a preterminal exposure of their lymphocytes to either BLM for the last 5 h or DEB for the last 24 h of incubation. However, the AR was higher in HNSCC patients than in the control group, suggesting an increase in the DNA repair capacity in the cancer patients as compared to the control. There is no correlation between the DNA repair capacity estimated on the basis of preterminal exposure to BLM and DEB and the DNA reapir capacity estimated on the basis of the adaptive response to DEB. The preterminal exposure and the adaptive response test may activate different DNA repair mechanisms.


    1793/2523

    Tytuł oryginału: A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17.
    Autorzy: Kowalska Anna, Hasegawa Masato, Miyamoto Katsuichi, Akiguchi Ichiro, Ikemoto Akito, Takahashi Keikichi, Araki Wataru, Tabira Takeshi
    Źródło: J. Appl. Genet. 2002: 43 (4) s.535-543, il., tab., bibliogr. s. 542-543
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • genetyka
  • neurologia

    Typ dokumentu:
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Mutations in the microtubule-associated tau gene are responsible for frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). A reduced ability of the mutated microtubule-associated tau protein to interact with microtubules causes microtubule destabilization leading to deleterious effects on axonal transport and the formation of tau filaments. Here, we describe a new mutation of the tau gene, a T - C transition at position +11 of the intron following exon 10 (T - C3'E10 + 11) in the family showing frontotemporal dementia with very early age of onset (the first decade of proband's life). The T - C 3'E10 + 11 mutation caused a large increase in the proportion of transcripts containing exon 10 detected by exon-trapping analysis. Our study confirmed that the T - C 3'E10 + 11 mutation as the other 5' splice site mutations of tau exon 10, modifies alternative splicing of exon 10.


    1794/2523

    Tytuł oryginału: Significance of chromosomal markers in the diagnosis of mantle cell lymphoma (MCL).
    Autorzy: Woroniecka Renata, Pieńkowska-Grela Barbara, Grygalewicz Beata, Rygier Jolanta, Witkowska Anna, Rymkiewicz Grzegorz, Jarosińska-Romejko Joanna
    Źródło: J. Appl. Genet. 2002: 43 (4) s.545-553, il., tab., bibliogr. s. 552-553
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: According to the REAL/WHO classification, the diagnosis of mantle cell lymphoma (MCL) should be based on clinical, histopathological, immunological and cytogenetic or molecular data. This study is based on 13 cases, which were initially diagnosed as MCL with the use of conventional cytogenetic method and fluorescent in situ hybridization (FISH). MCL is associated with a specific cytogenetic aberration t(11;14)(q12;q32). The chromosomal analyses confirmed the MCL diagnosis in four cases. A neartetraploid cell line and two copies of t(11;14) were observed in three cases. These results correspond with a blastoid variant of MCL, accompanied by aggressive course and poor prognosis. The presence of karyotype with t(11;14) as the sole anomaly predicts an intermediate clinical outcome. Six patients had normal karyotypes, which is characteristic for the typical form of MCL, associated with a better prognosis. In this study we show that detection of chromosomal abnormalities is useful in diagnosis of MCL and has some prognostic significance.


    1795/2523

    Tytuł oryginału: PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis.
    Autorzy: Drewnowska K. D., Craig M. R., Digiovanni S. R., McCarty J. M., Moorman A. F. M., Lamers W. H., Schoolwerth A. C.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.3-20, il., bibliogr. 33 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: To identify the nephron segments expressing PEPCK in control and acidotic conditions, PEPCK mRNA was localized in rat kidney using the technique of reserve transcription and polymerase chain reaction (RT-PCR) in individual microdissected S1, S2, and S3 segments of the rat proximal tubule. In controls, the number of tubules expressing PEPCK mRNA was greatest in the S3 segment, moderate in the S2 segment, and least in the S1 segment of the proximal tubule. After NH4Cl feeding, strong signals for PEPCK mRNA were detected in all three proximal tubule segments. In situ hybridization demonstrated expression of PEPCK mRNA only in the medullary rays in controls. After NH4Cl, PEPCK mRNA was expressed throughout the cortex, confirmning the RT-PCR results. These data demonstrate the ability of the rat kidney cortex to modulate the expression of PEPCK mRNA during metabolic acidosis by recruitment of additional cells in the proximal nephrons. Studies with cultured LLC-PK1-F+ cells indicated that increased PEPCK gene transcription at acid pH required a cis-acting element (enhancer) in the more distal 5' flanking region of the promoter.


    1796/2523

    Tytuł oryginału: Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa.
    Autorzy: Slomiany A., Nishikawa H., Slomiany B. L.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.21-38, il., bibliogr. 52 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Bacground: Performance of musocal epithelial barrier is modified by numerous agents that exert effects on mucin- Mucin Binding Protein (MBP) complex. The aim of the studies described was to determine the nature of the damage or modification of oral mucous barrier by the short-term exposure to ethanol. Methods: Culture of rat buccal mucosa in the presence of ethanol and [3H]-labeled proline and palmitate revealed decrease in MBP synthesis and the release of MBP to the medium. The radioscanning of the samples prepared from the culture medium and the apical epithelial membranes subjected to SDSPAGE and western blotting disclosed that the released, water soluble 97 Da MBP glycopeptide was lebeled with proline and palmitate. When the experiments were conducted in the presence of 5mM EDTA, the GPI-PLD inhibitor, the majority of radiolabeled MBP remained in the membrane-bound from and was extractable with Triton X-114. The results on the purified GPI-linked MBP degradation by serum enzyme, by the saliva containing serum transudate, and the suppression of the process by inclusion of GPI-PLD-specific inhibitor support our contention that membrane MBP is released to medium by GPI-PLD-like activity. Results: The release of MBP from apical epithelial surfaces was induced by depletion of mucin and the presence of serum-derived GPI-PLD in the tissue homogenate. Strong likelihood exists that under in situ conditions ethanol-induced transudation of serum to saliva provides the vehicle for the transfer of GPI-PLD activity to salivary contents...


    1797/2523

    Tytuł oryginału: Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury.
    Autorzy: Kwiecień S., Brzozowski T., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.39-50, il., bibliogr. 33 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Bacground: The exposure of gastric mucosa to damaging factors, such as ethanol, water restraint stress, or ischemia followed by reperfusion, procedures pathological changes; inflammatory process, hemorrhagic erosins, even acute ulcers. The base of these changes is a disturbance of protective mechanisms and disrupture of gastric mucosal barrier. Previous studies pointed out the role of disturbances of gastric blood flow, mucus secretion and involvement of prostaglandins and nitric oxide formation in the pathomechanism of gastric mucosa lesions. The role of reactive oxygen species (ROS) in these processes has been little studied. Aim: The purpose of our present investigations is to explain the participation of ROS in acute gastric mucosal damage by various irritants. Material and methods: Experiments were carrying out on 80 male Wistar rats. To assess gastric blood flow (GBF) laser Doppler flowmeter was used. The area of gastric lesions was established by planimetry. The levels of proinflammatory cytokines were measured by ELISA technique. The colorimetric assays were used to determine of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) as well as superoxide dismutase (SOD) activity. Results: We demonstrated that 3.5 h of water immersion and restraint stress (WRS), 30 min of gastric ischemia followed by 60 min of reperfusion or intragastric administration of 100 p.c. ethanol, all resulted in appearance of acute gastric mucosal lesions accompanied by a significant decrease of gastric blood flow. These lesions are also accompanied by the significant increase...


    1798/2523

    Tytuł oryginału: Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin.
    Autorzy: Jaworek J[olanta], Bonior J., Leja-Szpak A. K., Kot M., Tomaszewska R., Stachura J., Pawlik W. W., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.51-74, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Central nervous system affects pancreatic secretion of enzymes however, the neural modulation of acute pancreatitis has not been investigated. Leptin and melatonin have been recently reported to affect the inflammatory response of various tissues. The identification of specific receptors for both peptides in the pancreas suggests that leptin and melatonin could contribute to the pancreatic protection against inflammation. The aim of this study was: 1) to compare the effect of intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) administration of leptin or melatonin on the course of caerulein-induced pancreatitis (CIP) in the rat, 2) to examine the involvement of sensory nerves (SN) and calcitonin gene-related peptide (CGRP) in pancreatic protection afforded by leptin or melatonin, 3) to assess the effect of tested peptides on lipid peroxidation products (MDA + 4-HNE) in pancreas of CIP rats, 4) to investigate the influence of leptin or melatonin on nitric oxide (NO) release from isolated pancreatic acini and 5) to determine the effects of caerulein and leptin on leptin receptor gene expression in these acini by RT-PCR was induced by subcutaneous (s.c.) infusion of caerulein (25 ćg/kg) to the conscious rats, confirmed by the significant increases of pancreatic weight and plasma amylase and by histological examination. This was accompanied in marked reduction of pancreatic blood flow and significant rise of MDA + 4HNE in the pacreas. Leptin or melatonin were administered i.p. or i.c.v. 30 min prior to the start of CIP...


    1799/2523

    Tytuł oryginału: Central histamine-induced reversal of critical haemorrhagic hypotension in rats - haemodynamic studies.
    Autorzy: Jochem J[erzy]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.75-84, il., bibliogr. 22 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Volume-controlled irreversible haemorrhagic shock in rats produced by blood withdrawal until stabilisation of critical mean arterial pressure (MAP) 20-25 mmHg is associated with an extreme decrease in cardiac index (CI) and an increase in total peripheral resistance index (TPRI), with reductions in renal (RBF), hindquarters (HBF) and mesentric blood flow (MBF), and leads to the death of all control animals within 30 min. Histamine (100 nmol) injected intracerebroventricularly (i.c.v.) in the early phase of critical hypotension produces a prompt and long-lasting increase in MAP and heart rate, with a 100 p.c. survival for 2 h after treatment. The effects are associated with the rise in the circulating blood volume and CI, and the decrease in TPRI, with the increase in RBF and HBF, and persistently lowered MBF. Both splenectomy and ligation of the suprahepatic veins inhibit histamine-induced increase in circulating blood volume as well as cardiac and regional haemodynamic effects. It can be concluded that histamine administered icv activates central endogenous compensatory mechanisms, which leads to the reversal of haemorrhagic shock conditions due to mobilisation of blood from venous reservoirs, the increase in circulating blood volume and its redistribution. Moreover, histamine evokes the rises in CI and perfusion of the renal skeletal muscle vascular regions.


    1800/2523

    Tytuł oryginału: Influence of the corticotropin releasing hormone (CRH) on the brain-blood barrier permeability in cerebral ischemia in rats.
    Autorzy: Hendryk S[tanisław], Jędrzejowska-Szypułka H., Jośko J., Jarząb B., D”hler K. D.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.85-94, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The increase in the blood-brain barrier (BBB) permeability and a developing cerebral oedema due to the ischemic infarction appear a few hours, and intensity during a few days, after closing the carotid arteries. It fails to be clear, however, what causes the increase in the microvessels damage, and whether the damage is a secondary result of the vasoactive substances released by the neurones and glia cells damaged by the ischemia. CRH, which plays an essential role in integrative the nervous, endocrine, and immunological systems, has a positive effect on the decrease in the permeability of the BBB damaged by various physical and chemical factors. Therefore, the examination of the CRH role in the cerebral ischemia may prove useful for explaining the processes taking place in the foci of the cerebral infarction and their environment. The experiment was carried out on rats which, 20 minutes before closing of both internal carotid arteries, was administered 10 ćg CRH to cerebrospinal fluid via cisterna magna of the brain. The BBB permeability was measured 30 minutes, 3 hours, 3 days, and 7 days after closing the arteries. The experiment has shown the CRH protective effect on the BBB and its consequent effect on the decrease in the BBB permeability which appeares in the 3 hours after closing the arteries (p 0.05), and is high significant during the chronic phase of the cerebral ischemia (p 0.03). It can be thus concluded that CRH, by affecting directly the endothelium of the cerebral vesels, decreases the endothelial damage in the acute phase of the ischemia. The decrease is noted to be more significant in the chronic phase of the ischemia...


    1801/2523

    Tytuł oryginału: Cytokines regulate plasminogen activation system in astrocytoma cells.
    Autorzy: Kasza A., Koj A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.95-104, il., bibliogr. 23 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We report here that human astrocytoma cell line U373-MG is able to express gene of the following components of plasminogen activation system: PAI-1, PN-1, u-PA and t-PA. Treatment of these cells with IL-1á results in accumulation of PAI-1, PN-1 and u-PA mRNAs, whereas t-PA mRNA remains unaffected. IFNç preferentialy enhances PN-1 and PAI-1, EGF enhances PAI-1, uPA and t-PA expression. Simultaneous addition of anti-inflammatory cytokines IL-4, IL-13 and IL-10 has little effect on the tested components, except induction of u-PA mRNA which was further enhanced by IL-4. We have confirmed interesting time-dependent regulation of plasminogen activation system by EGF/IFNç show at first increased proteolytic activity but after 24 h inhibition of proteolysis with PAI-1 would prevail. To understand the cooperative effect of EGF and IFNç in PAI-1 induction the kinetics of activation of STAT1 was studied. It was found that although EGF alone does not activate STAT1, the STAT1 binding activity in he cells treated with the mixture of EGF/IFNç was considerably prolonged. Our results indicate the importance of inflammatory cytokines and EGF in gene regulator of plasminogen activation system in astrocytoma cells.


    1802/2523

    Tytuł oryginału: Effect of repeated treatment with mirtazapine on the central ŕ1-adrenergic receptors.
    Autorzy: Rogóż Z[ofia], Wróbel A., Dlaboga D., Dziedzicka-Wasylewska M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.105-116, tab., bibliogr. 38 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Mirtazapine (MIR) is an antidepressant which enhances noradrenergic and serotonergic 5-HT1A neurotransmission via antagonism of central ŕ2-adrenergic autoreceptors and heteroreceptors. The drugs does not inhibit noradrenaline and serotonin reuptake but blocks the 5-HT2 and 5-HT3 receptors and has high affinity only for central and peripheral histamine H1 receptors. The present study was was aimed at determining whether repeated MIR treatment induced adaptive changes in the ŕ1-adrenergic receptors, similar to those reported by us early for tricyclic antidepressants. The experiments were carried out on male mice and rats. MIR was administered at a dose of 10 mg/kg oce or repeatedly (twice daily for 14 days). The obtained results showed that MIR administrated repeatedly potentiated the methoxamine- induced exploratory hyperactivity in rats and clonidine-induced aggressiveness in mice, those effects being mediated by ŕ1-adrenergic receptors. MIR given repeatedly (but not acutely) increased the binding (Bmax) of [3H]prozosin to ŕ1-adrenergic receptors in cerebral cortex, however, the ability of the ŕ1-sdrenoreceptor agonist phenylephrine to compete for the these sites was not significantly changed. The above results indicate that repeated MIR administration increases the responsiveness of ŕ1-adrenergic system (behavioural and biochemical changes), as tricyclic do. However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open.


    1803/2523

    Tytuł oryginału: Effect of tianeptine and fluoxetine on the levels of Met-Enkephalin and mRNA encoding proenkephalin in the rat.
    Autorzy: Dziedzicka-Wasylewska M., Dlaboga D., Pierzchała-Koziec K., Rogóż Z[ofia]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.117-125, tab., bibliogr. 42 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The purpose of the present study was to evaluate the effects of acute and repeated treatment with two antidepressant drugs (ADs) of opposite pharmacological profile, i.e. tianpetine (TIA, serotonin reuptake enhancer) and fluoxetine (FLU, serotonin reuptake inhibitor) on the levels of Met-Enkephalin, (Met-Enk, a member of opioid peptidefamily, which has been suggested to play a role in the mechanism of action ADs) as well as on mRNA coding for proenkephalin (mRNA PENK) in various regions of the rat brain, pituitary, drenal glands and plasma. male Wistar rats treated acutely or repeatedly (10 mg/kg p.o., twice daily for 14 days) with TIA or FLU. Tissue for biochemical experiments was taken 2 h after last dose of appropriate drug. The levels of Met-Enk were estimated by radioimmunoassay, mRNA PENK was measured using in situ hybridization. From the results obtained in the present study it may be concluded thart repeated adminiostration of TIA or FLU induced similar changes in the levels of Met-Enk in the rat hippocampus, striatum, hypothalamus and neurointermediate lobe of pituitary. Such an effect is interesting, especially if one takes into account the differences in pharmacological profile between these two antidepressant drugs. It may be suggested that serotonin level might not be crucial for inducing the alterations in the content of Met-Enk. Since we did not observe any changes in the levels of PENK mRNA in the studied rat brain regions after repeated administration of TIA or FLU, it seems that the observed changes in the levels of Met-Enk...


    1804/2523

    Tytuł oryginału: Eosinophil - epithelial cell interaction augments cysteinyl leukotrienes synthesis.
    Autorzy: Jawień J[acek], Chłopicki S., Olszanecki R., Lorkowska B., Gryglewski R. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.127-132, il., bibliogr. 17 poz.
    Sygnatura GBL: 302,092

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Eosinophilis accumulation in the airways and sustained eosinophil-derived cysteinyl leukotrienes production repesent key elements of the inflammatory response seen in asthma. However, it is not known whether activated epithelial cells influence cysteinyl leukotrienes production by eosinophils from healthy valunteers. The aim of the present study was therefore to analyse the effects of interactions between non-atopic eosinophils and epithelial cells on cysteinyl leukotrienes production in vitro. We measured cysteinyl leukotrienes released by phorbol 12-myristate 13-acetate (PMA) - activated human eosinophils or epithelial cells (human bronchial epithelial cell line - BEAS-2B) cultured alone or together. While activated BEAS-2B cells barely formed leukotrienes (1.39 pg/ml ń 0.2) (n = 32), activated eosinophilis produced considerable amount of them (62.25 pg/ml ń 10.29) (n = 32). Interestingly, when activated eosinophils and epithelial cells were co-incubated, production of cysteinyl leukotrienes increased substantially (571.1 pg/ml ń 80.9) (n = 32). Thus, eosinophil-epithelial cell interactions, when occur, are associated with increased biosynthesis of cysteinyl leukotrienes.


    1805/2523

    Tytuł oryginału: A comparative study of the acute hematotoxicity of three ethylene glycol monoalkyl ethers in rats.
    Tytuł polski: Badania porównawcze nad ostrym hematotoksycznym działaniem trzech eterów glikolu etylenowego u szczurów.
    Autorzy: Starek Andrzej, Lepiarz Włodzimierz, Starek-Świechowicz Beata, Jarosz Jolanta
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.1-16, il., bibliogr. 19 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Celem pracy było porównanie hemolitycznego działania metoksyetanolu (ME), etoksyetanolu (EE) i butoksyetanolu (BE) u szczurów Wistar, samców. ME i EE podawano podskórnie w dawce jednorazowej 2,5, 5,0 i 10,0 mmol/kg, podczas gdy BE w taki sam sposób w dawce 1,25, 2,5 i 5,0 mmol/kg. We krwi obwodowej oznaczono liczbę erytrocytów, hematokryt, średnią objętość krwinek, liczbę retikulocytów, stężenie hemoglobiny całkowitej i osoczowej oraz średnie stężenie hemoglobiny w krwinkach i w pojedynczych erytrocytacgh. Oznaczenie wykonywano do 144 godz. po podaniu badanych związków, a w przypadku BE podanego w dawce 2,5 mmol/kg do 25 dnia po badaniu. Zmiany hematologiczne były najsilniej zaznaczone po 24 godz. po podaniu badanych związkow i utrzymywały się przez długi okres czasu, nawet do 25 dnia po podaniu BE. BE wywierał 8- i 4-krotnie silniejsze działanie hemolityczne w porównaniu kolejno z ME I EE. Po podaniu BE zmiany hematologiczne korelowały z dawką tego związku. Zmiany większości wskaźników hematologicznych wykazywały korelację liniową z liczbą atomow węgla w lańcuchach alkilowych badanych eterów. W pracy zwrócono uwagę na niektore mechanizmy obserwowanych zjawisk.

    Streszczenie angielskie: 2-Methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol are massively produced and widely used ethylene glycol ethers. This creates a high hazard for humans during their manufacture and use. A single exposure of rats to 2-butoxyethanol caused severe hemolytic anemia. The present studies were undertaken to compare the acute hematotoxicity of 2-methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol in male rats. Dose-, time-, and total number of ether carbon-dependent hemolytic effect of these chemicals were seen. The hemolytic action of 2-butoxyethanol was 4 and 8-fold higher than in case of 2-ethoxyethanol and 2-methoxyethanol, respectively. In summary, the current studies indicate that the hemolytic effect of ethylene glycol monoalkyl ethers can be attributed to their chemical structure, especially to the length of the carbon chain.


    1806/2523

    Tytuł oryginału: Morphological and cellular damage to some organs and changes in adrenocortical function parameters induced by equitoxic mixture fenitrothion/thiram in rats.
    Tytuł polski: Uszkodzenia struktury morfologicznej i komórek niektórych narządów oraz zmiany wskaźników aktywności kory nadnerczy u szczurów zatruwanych równotoksyczną mieszaniną fentrotionu i tiuramu.
    Autorzy: Wysocka-Paruszewska Bożena, Kamiński Marcin, Osicka-Koprowska Anna, Brzeziński Jacek
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.17-32, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Celem znalezienia odpowiedzi biologicznej na łączne oddziaływanie fenitrotionu i tiuramu badano wpływ podchronicznego zatrucia ich równotoksyczną mieszaniną (5 proc. LD50, 90 dni) na strukturę morfologiczną i komórkowe enzymy wskaźnikowe (Mg+2 ATPase, AcP) wątroby, nerek, nadnerczy i mózgu oraz na poziom kortykosteronu w osoczu, kwasu askorbinowego i cholesterolu w nadnerczach. Badano także wpływ mieszaniny na masy ciała i badanych narządów. Wyniki badania morfologicznego nie wykazały różnic w oddziaływaniu mieszaniny w porównaniu do jej składników pojedynczo. Różnice te były nieznaczne w porównaniu z grupą kontrolną. Natomiast w badaniu histochemicznym obserwowano najsilniejsze zmiany w aktywności reakcji enzymatycznych po zatruciu mieszaniną, wskazujące na wystąpienie interakcji toksykologicznej w zatruciu subchronicznym. Zmiany aktywności obu enzymów najsilniej zaznaczone były w wątrobie, a Mg+2 rownież w nerce. Po zatruciu mieszaniną nastąpił wzrost masy nadnerczy. Obserwowany wzrost poziomu kortykosteronu w osoczu był związany z oddziaływaniem tiuranu i nie był istotny statystycznie. poziom kwasu askorbinowego i cholesterolu w nadnerczach nie uległ zmianie ani w porownaniu do zwierząt kontrolnych ani otrzymujących składniki mieszaniny pojedynczo.

    Streszczenie angielskie: To find the biological response to the subchronic joint action of fenitrothion and thiram the effects of their mixture (5 p.c. LD50, 90 days) on morphological structure, cellular enzymatic markers (Mg+2 APtase, AcP) of rat liver, kidneys, adrenals and brain as well as the plasma corticosterone level and the adrenal ascorbic acid and cholesterol contents were examined. The influence of the mixture on the total body weight and on the weights of the organs of interest was also studied. Morphological analysis did not show enhanced action of the mixture when compared to the action of its individual components. However, histochemical studies demonstarated that the strongest changes in the activities of marker enzymes appeared after intoxication with the mixture of pesticides, what indicates toxicological interaction during subchronic intoxication. Changes in the activity of both enzymes were most evident in the liver, and, in the case of Mg+2 APTase, also in the kidneys. The markedly elevated plasma corticosterone level followed intoxication with the mixture, but the increase was statistically insignificant. It was due to the action of thiram, since fenitrothin had no effect on plasma corticosterone level. The adrenal levels of ascorbic acid and cholesterol were not affected in any of the experimental groups. Weights of adrenals were significantly increased in the group treated with the equitoxic mixture.


    1807/2523

    Tytuł oryginału: Polychlorinated biphenyls induce changes in glial fibrillary acidic protein levels in rat brain.
    Tytuł polski: Polichlorowane bifenyle indukują zmiany poziomu kwaśnego włóknistego białka glejowego (GFAP) w mózgu szczura.
    Autorzy: Małkiewicz Katarzyna, Benedikz Eirikur, Folkesson Ronnie, Winblad Bengt, Kamiński Marcin, Brzeziński Jacek
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.33-43, il., tab., bibliogr. 29 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Badanie działania neurotoksycznego polichlorowanych bifenyli oparte było na pomiarze zmian stężenia Kwaśnego Włóknistego Białka Glejowego (GFAP) w częściach anatomicznych mózgów szczurów narażanych na Aroclor 1254. Szczurom, samcom, stada Wistar podawano doustnie Aroclor w dawkach 100 mg/kg/dzień przez 6 dni lub 350 mg/kg/dzień przez 4 dni. Badanie histologiczne mózgów oraz pomiar białka GFAP metodą ELISA-sandwich wykonywano po 2 i 21 dniach od zakończenia narażenia na ksenobiotyk. Zwierzęta narażane na niższą dawkę przeżyły cały okres doświadczenia, w grupie narażonej na wyższą dawkę zanotowano 50 poc. śmiertelność po 2 dniach, a po 21 tylko jedno z sześciu zwierząt pozostało przy życiu. Zwierzęta narażone na PCBs wykazywały zahamowanie przyrostu masy ciała. Wyniki oznaczania stężenia białka GFAP w częściach anatomicznych mózgów szczurów narażanych na Aroclor 1254 w odniesieniu do kontrolnych wykazywały statystycznie istotny 21 proc. wzrost stężenia tego białka w rdzeniu przedłużonym i 14 proc. w móżdżku zwierząt narażonych na niższą dawkę, badanych po 2 dniach i odpowiednio 27 proc. i 11 proc. po 21 dniach. W grupie narażonej na wyższą dawkę statystycznie istotny wzrost po 2 dniach obserwowano w móżdżku (16 proc.) i w hipokampie (54 proc.). Zaobserwowano również zmiany histopatologiczne w móżdżku i korze mózgowej szczurów narażanych na niższą dawkę Arocloru 1254. Wyniki te wskazują, że ekspozycja młodych szczurów na mieszaninę techniczną polichlorowanych bifenyli - Sroclor 1254 powoduje zmiany poziomu białka GFAP, którym towarzyszą zmiany histopatologiczne co świadczy o neurotoksycznym oddziaływaniu tych ksenobiotyków.

    Streszczenie angielskie: To assess the polychlorinated biphenyls (PCBs) neurotoxicity, Aroclor 1254 was administered orally to rats (100 mg/kg/day for days or 350 mg/kg/days). After 2 or 21 days following treatment glial fibrillary acidic protein (GFAP) level in brain regions and histological studies were done. PCBs-treated rats showed statistically significant GFAP-level increase in medulla oblongata, cerebellum and hipocampus. PCBs--induced histopathological changes in cerebellum and cortex were observed. These results showed that oral exposure of young rats to Aroclor 1254 resulted in GFAP-level increase accompanied by histological abnormalities in brain confirming that this mioxture of PCB's is neurotoxic.


    1808/2523

    Tytuł oryginału: Effect of sulphur yperite on selected elements of oxidative stress in blood platelets - in vitro studies.
    Tytuł polski: Wpływ iperytu siarkowego na wybrane elementy stresu oksydacyjnego w krwinkach płytkowych - badania in vitro.
    Autorzy: Gnitecki Witold, Buczyński Andrzej, Kowalski Wojciech, Stopczyk Dariusz
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.45-51, il., bibliogr. 21 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie
  • in vitro

    Streszczenie polskie: Iperyt siarkowy (gaz musztardowy, siarczek á,á'-dichloroetylowy) należy do grupy bojowych środków trujących o działaniu parzącym. Wciąż małopoznany jest wpływ iperytu siarkowego na metabolizm tlenowy organizmu człowieka. Dlatego głównym celem pracy było zbadanie in vitro wybranych wskaźników stresu oksydacyjnego w krwinkach płytkowych poddanych działaniu tego związku. Aktywność katalazy (Cat) oznaczano metodą Beersa i Sizera, peroksydazy glutationowej (GPx) testem RANSEL firmy RANDOX. Poziom generacji reaktywnych form działania tlenu oceniano pomiarem chemiluminescencji. Iperyt siarkowy inkubowany z krwinkami płytkowymi indukuje istotny wzrost aktywności katalazy w porównaniu do obu prób kontrolnych. Aktywność peroksydazy glutationowej była znamiennie wyższa w porównaniu do próby z solą fizjologiczną jak i glikolem propylenowym. Nie stwierdzono istotnych statystycznie różnic w pomiarze chemiluminescencji krwinek płytkowych w próbkach kontrolnych jak i w próbie badanej. Zaprezentowane przez nas wyniki są uzupełnieniem wcześniej przeprowadzonych badań. Poprzednio uzyskano znamienne podwyższenie aktywności dyzmutazy ponadtlenkowej oraz istotny wzrost poziomu MDA w krwinkach płytkowych inkubowanych z iperytem siarkowym o stężeniu 10**-5 M i 10**-3 M. Uzyskane wyniki skłaniają by sądzić, że gaz musztardowy in vitro wpływa destrukcyjnie na błonę komórkową zwiększając peroksydację lipidów co prowadzi do wzrostu stężenia MDA. Podwyższenie aktywności enzymów antyoksydacyjknych takich jak dyzmutaza ponadtlenkowa, katalaza, peroksydaza glutationowa nie zapobiega szkodliwemu dzialaniu wolnych rodników. Brak wyraźnych zmian w chemiluminescencji sugeruje, że RFT (reaktywne formy tlenu) do pewnego stopnia są neutralizowane przez niewydolny układ antyoksydacyjny.

    Streszczenie angielskie: The puropse of this study was to measure the activity in vitro of antioxidant enzymes such as catalase (Cat), glutathione peroxidase (GPx) and to estimate the level of reactive oxygen species (ROS) production in blood platelets after exposition to mustard fas at the concentration of 10**-5 M. The level of ROS production was estimated by chemiluminescence measurment. In blood platelet sulphur yperite increases the activity of catalase. Our study demonstrated that mustard gas significantly induced the activity of glutathione peroxidase. There was no significant stimulatory effect of sulphur yperite on the chemiluminescence of platelets.


    1809/2523

    Tytuł oryginału: Study on the applicability of gas chromatography and spectrophotometry for the evaluation of carboxyhemoglobin in autopsy blood in the course of putrefaction.
    Tytuł polski: Badania nad przydatnością chromatografii gazowej i spektrofotometrii do oceny zawartości hemoglobiny tlenkowęglowej we krwi sekcyjnej w toku jej przemian gnilnych.
    Autorzy: Kłys Małgorzata, Klementowicz Wiesława, Gomułka Ewa, Duda Urszula
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.53-64, il., tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • prawo
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy dokonano oceny porównawczej oznaczeń karboksyhemoglobiny (COHb) we krwi przy pomocy chromatografii gazowej z metanizerem jako katalizatorem przekształceń tlenku węgla w metan (CO/CH4) oraz metody spektrofotometrycznej jako metody odniesienia. Analiza wykonana dla 59 próbek krwi sekcyjnej pobranej w przypadkach podejrzenia zatrucia śmiertelnego tlenkiem węgla, przechowywanych w lodówce od 1 dnia do 245 dni wykazała negatywny wpływ przekształceń gnilnych na wartości COHb, otrzymanych metodą spektrofotometryczną. Oprócz oceny COHb wykonano spektrofotometrycznie oznaczenia methemoglobiny (MetHb) oraz sulfhemoglobiny (SulfHb) w tych próbach krwi, a ich wzrastające zawartości wskazywały na nasilenie procesów gnilnych. zawartość COHb, MetHb i SulfHb oznaczone w próbkach krwi, przechowywane w warunkach tlenowych i beztlenowych przez 170 dni w toku realizacji podjętego eksperymentu wykazywały różnice, wynikające z warunków przechowywania.

    Streszczenie angielskie: A comparative evaluation of carboxyhemoglobin (COHb) in autopsy blood by gas chromatography combined with a methanizer catalysing carbon monoxide conversion to methane (CO/CO4) and by spectrophotometry used as a reference method was performed. Samples of autopsy blood (n=59) taken from subjects suspected of having been fatally poisoned with carbon monoxide were analysed. These samples, stored in a refrigerator from 1 to 245 days, showed a negative effect of decomposition changes on COHb value recorded spectrophotometrically. Apart from evaluation of COHb, spectrophotometry was used for the determination of methemoglobin (MetHb) and sulfhemoglobin (SulfHb) (in those blood samples) and their increasing contens indicated the intensification of decompsition. The contents of COHb, MetHb and SulfHb determined in 36 blood samples, stored in aerobic and anaerobic conditions for 170 days in the course of the experiment, showed differences due to the storage conditions.


    1810/2523

    Tytuł oryginału: Inhibitory effects of ammonia solution on growth and aflatoxins production by Aspergillus parasiticus NRRL-2999.
    Tytuł polski: Hamujący wpływ roztworu amoniaku na wzrost i wytwarzanie aflatoksyn przez Aspergillus parasiticus NRRL-2999.
    Autorzy: Namazi M., Allameh A., Aminishahidi M., Nohee A., Malekzadeh F.
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.65-72, il., bibliogr. 35 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Aflatoksyny wytwarzane są przez toksykogenne grzyby, które rosną na żywności i paszach stwarzając zagrożenie dla ludzi i zwierząt. Amonowanie produktów rolnych celem usunięcia aflatoksyn z karmy dla zwierząt jest w szeregu krajów praktykowane z dobrym skutkiem. W przedstawionych badaniach do rosnących kultur grzybowych wytwarzających aflatoksyny dodano amoniak tak, aby jego stężenie wynosiło od 0.1 do 1.0 proc. obj. i badano sposób jego oddziaływania na wzrost i wtórny metabolizm Asoergillus parasiticus-NRRL 2999. Jako płynu hodowlanego do utrzymania wzrostu kultur i wytwarzania aflatoksyn użyto SLS (Sucrose Low Salt). Amoniak dodawano do 50 ml płynu hodowlanego, a próbki płynu i grzybni pobierano do badania po 2, 5, 8 12 i 16 dniach. Wyniki wskazują na zależny od stężenia wpływ amoniaku na wzrost grzybni. Stosownie do stężenia wytwarzanie aflatoksyn (całkowite - B1 + B2 + G1 + G2) jest zahamowane. Stwierdzono, że wzrost grzybów wraz z wytwarzaniem aflatoksyn był zahamowany przy stężeniu amoniaku 0,9 - 1,0 proc. Dane te pozwalają sugerować, że końcowe stężenie 1 proc. amoniaku jest wystarczające do bezpiecznego amonowania roślin przeznaczonych na paszę dla zwierząt.

    Streszczenie angielskie: Aflatoxins are produced by certain toxogenic fungi which grow on a variety of food and feed stuffs and pose a serious threat to human and animals. Ammoniation of agricultural products to eliminate aflatoxins from animal feed stuffs has been sucesfully oracticed in some countries. In this study, various concentrations of ammonia solution (0, 0.1, 0.2, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 and 1.0 p.c. v/v) have been added to culture growth of a aflatoxin-producing fungi to investigate the mode of action of ammonia solution on Aspergillus parasiticus-NRRL 2999 growth and secondary metabolism. Sucrose Low Salt (SLS) media has been used as a specific medium which supports the aflatoxin production and culture growth. Different concentrations of amonia solution has been added to 50-ml culture media and sampling from media and mycelia has been carried out at different time intervals (2, 5, 8, 12 and 16 days). The result show that there is a concentration-dependent inhibitory effect of ammonia solution on mycelial growth. According the concentration of total alfatoxins (B1 + B2 + G1 + G2) produced is inhibited. It was found that fungal growth together with aflatoxin production has been diminished in flasks containing 0.9 - 1.0 p.c. ammonia. These data may suggest that a final concentration of 1 p.c. ammonia is sufficient to be used safety in commercial ammoniation plant of feed destined for animal consumption.


    1811/2523

    Tytuł oryginału: Influence of biological and environmental factors on bio-accumulation of fluorine in lower jaws of ruminants.
    Tytuł polski: Wpływ czynników biologicznych i środowiskowych na bioakumulację fluoru w żuchwach przeżuwaczy.
    Autorzy: Machoy-Mokrzyńska Anna, Mokrzyński Stanisław
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.73-80, il., tab., bibliogr. 28 poz., streszcz. - Konferencja pt. Toksykologiczne i farmakologiczne aspekty działania ksenobiotyków Olsztyn 07-08.09. 2000
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • ochrona środowiska
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie polskie: Praca dotyczy wpływu czynników biologicznych i środowiskowych na bioakumulację związków fluoru w tkance kostnej przeżuwaczy. Analizowano zawartość fluorkow w różnych fragmentach kości żuchwy jeleni i koziołków z Pomorza Zachodniego. Otrzymane wyniki mogą służyć do monitorowania skażenia środowiska związkami fluoru.

    Streszczenie angielskie: The paper assesses the influence of biological and environmental factors on bio-accumulation of fluorine compounds in osseous tissue of ruminants. Until now, the content of fluorides in various fragmebts of the lower jaw of red deer and role deer from the West Pomerania was analysed. The reults obtained can be used for the monitoring of environmental contamination with fluorine compounds.


    1812/2523

    Tytuł oryginału: Effect of increased ozone concentration in the air on the level of some immunological indices in rats given vitamin E and vitamin C.
    Tytuł polski: Wpływ zwiększonego stężenia ozonu w powietrzu na poziom niektórych wskaźników immunologicznych u szczurów otrzymujących witaminę E i C.
    Autorzy: Jedlińska-Krakowska Maria, Jakubowski Karol, Kowalski Andrzej
    Źródło: Acta Pol. Toxicol. 2002: 10 (1) s.81-87, tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: U samców szczurów szczepu Wistar/Han eksponowanych przez 50 dni po 5 godz. dziennie na 0.5 ppm ozonu badano wpływ witaminy E i C (iniekowanych pojedynczo i łącznie) na aktywność granulocytów obojętnochłonnych i transformację blastyczną limfocytów. Wykazano, że stosowane witaminy podwyższały obniżoną u ozonowanych zwierząt transformację blastyczną limfocytów i zwiększały aktywność granulocytów obojętnochłonnych.

    Streszczenie angielskie: The effect if vitamins E and C (injected separately and together) on the activity of neutrophilic granulocytes and blastic transformation of lymphocytes was studied in male Wistar-Hanover rats exposed for 50 days, 5 hours a day, to 0.5 ppm of ozone. It was found that vitamins E and C increased the index of blastic transformation of lymphocytes - decreased in ozone-exposed animals - and the activity of neutrophilic granulocytes.


    1813/2523

    Tytuł oryginału: Personality, responsibility, disability.
    Tytuł polski: Osobowość, odpowiedzialność, niepełnosprawność.
    Autorzy: Pachalska Maria
    Źródło: Ortop. Traumatol. Rehabil. 2002: 4 (6) s.731-746, il., tab., bibliogr. 36 poz., streszcz.
    Sygnatura GBL: 313,531

    Hasła klasyfikacyjne GBL:
  • neurologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wstęp. U pacjentów po urazach głowy obserwuje się często nieodpowiedzialne zachowania, bez względu na to, czy wykazują oni, czy też nie, cechy tzw. zespołu czołowego. W związku z tym rodzi się problem ich odpowiedzialności w kontekście zarówno moralnym, jak i prawnym. Zagadnienie to nie znalazło jednak do tej pory miejsca w literaturze przedmiotu. Opis przypadków. Praca stanowi studium trzech przypadków lekarzy różnych specjalności po urazach głowy, którzy przebywali w śpiączce. Standardowe badania neuropsychologiczne przeprowadzone przed i po rehabilitacji wykazały poprawę w zakresie wszystkich badanych funkcji poznawczych oraz ustąpienie cech zespołu czołowego. Pomimo prób powrotu do pracy żaden z przedstawionych tu trzech pacjentów nie jest jednak w stanie nadal pracować w zawodzie lekarza. Co więcej, ich życie osobiste uległo wysokiej dezorganizacji. Dyskusja i wnioski. Problematyka odpowiedzialności powinna być rozpatrywana łącznie z problematyką osobowości oraz zaburzeniami osobowości wywołanymi niepełnosprawnością, a w szczególności urazem mózgu. U podstaw nieodpowiedzialnego zachowania się badanych pacjentów leżą istniejące specyficzne cechy ich charakteru, które w następstwie urazu mózgu nasilają się i przyjmują inny kształt. W artykule proponuje się nowe podejście do rozumienia wzajemnych związków tak złożonych pojęć, jak: osobowość, moralność, odpowiedzialność w przypadku osoby, która doznała uszkodzenia mózgu.

    Streszczenie angielskie: Introduction. Patients recovering from head trauma, whether or not they exhibit signs of frontal syndrome, often behave irresponsibly and the problem of their moral and legal responsibility for their actions arises very often. To date, however, this issue has bot been systematically addressed in the literature. case report. The present study is a case study patients, all physicians of different specialites who suffered head injuries resulting in coma. Standard neuropsychological tests administered before and after rehabilitation indicate improvement in all tested cognitive functions and resolution of frontal symptoms. However, despite their efforts none of these patients has been able to return to professional works as a physician, and their personal lives are in disarray. Discussion and conlusions. The problem of responsibility is inseparable from the problem of personality and disturbances in personality caused by disability, especially brain damage. The irresponsible behavior exhibited by these patients can be traced to pre-existing character traits which are differently expressed after the head injury. The article suggests a new approach to understanding the interreationship of such complex concepts as personality, character, mortality, and responsibility in the case of a person who has suffered organic impairment of brain function.


    1814/2523

    Tytuł oryginału: Importance of a single point mutation of the bovine leukemia virus (BLV) envelope glikoprotein in the serological detection of BLV infection.
    Autorzy: Reichert Michał
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.17-26, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • genetyka
  • mikrobiologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: The purpose of this study was (i) to compare the gp51 part of the BLV env gene cloned in Poland with other clones from different parts of the world and (ii) to investigate the possible influence of genetic variation on the immune reaction of the host. The mean variability of the Polish clones, as compared with all the isolates, did not exceed 4 p.c. When compared with the European clones it was only 1.3 p.c. The study allowed classifying the Polish clones within the European subgroup of BLV variants. One particular mutation i.e. presence of Ala-58 instead of Ser-58, found in an immunologically important region of the Polish variants, influenced the results of serological diagnosis of BLV infection of the cows and be of importance in the epidemiology of BLV infections.


    1815/2523

    Tytuł oryginału: Comparison of primer sets for the detection of bovine leukemia virus by polymerase chain reaction.
    Autorzy: Limansky Alexander P., Limanskaya Olga Yu.
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.27-36, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: Comparison of theoretical and experimental results of the selection of primes suitable for bovine leukemia virus detection by PCR was presented. It was shown that primer sets characterised with 100 p.c. homology degree for all the BLV isolates and without palindromic regions within amplicon had good accuracy and reliability. Primers designed by multiple alignment and thermodynamic characteristics are proposed as universal ones for BLV detection by PCR.


    1816/2523

    Tytuł oryginału: Modulating effects of Uncaria tomentosa in experimentally-induced local pneumonia in calves.
    Autorzy: Bednarek Dariusz, Łukasiak Jerzy, Kondracki Marian, Żurowska Katarzyna, Falkiewicz Bogdan, Niemczuk Krzysztof
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.65-77, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • toksykologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: The aim of the study was to investigate the influence of Uncaria tomentosa (Vilcacora) on the course of an experimentally induced local pneumonia in calves. The study was performed on 20 calves suffering from an induced lung inflammation. The animals were divided into two equal groups. The calves from group I were treated orally with 3600 mg/calf/day of Uncaria tomentosa for 17 consecutive days. The calves of group II served as controls and received placebo. A series of routine haematological parameters, inflammatory markers (serum and bronchoalveolar eicosanoids such as LTB4, TXB4, PGE2, PGF2ŕ and also Fe, Zn, Cu) and immunophenotype of peripheral blood lymphocyte subsets (T, Th, Ts/Tc, B) were assayed in the calves. Additionally, the body temperature was examined every day during the experiment. Significant changes caused by the development of lung inflammatory process and the regulating influence of Uncaria tomentosa were found in calves with regard to their clinical status and laboratory-tested parameters. The rectal temperature significantly increased in the untreated animals and it remained on the higher level until the tenth day of the obsevation. The examination of the peripheral lymphocyte subsets in the calves from group I revealed a significant increase in the total number and percentage of CD2 + and CD4+ cells. On the other hand, the systematic decrease in the peripheral blood neutrophil and MID-cell number was observed. Finally, on the last day of the experiment, the values were significantly lower, compared with their initial values...


    1817/2523

    Tytuł oryginału: Effect amifostine on lung oxidative stress after cyclophosphamide therapy.
    Autorzy: Stankiewicz Anna, Skrzydlewska Elżbieta, Sulkowska Mariola, Sulkowski Stanisław
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.87-94, tab., bibliogr. 26 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • toksykologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The ability of amifostine to protect healthy rat lung cells from cyclophosphamide-induced injury was evaluated. It was shown that cyclophosphamide decreased the activity of superoxide dismutase, gluthatione reductase and catalase as well as the level of reduced gluthatione, vitamin C and total antioxidant status and increased lipid peroxidation measured as malondialdehyde. Amifostine alone did not change or cause the increase in the antioxidative parameters and decrease in lipid peroxidation. Amifostine with cyclophosphamide only partially prevented changes in lung cells caused by cyclophosphamide.


    1818/2523

    Tytuł oryginału: Effect of cadmium and ionizing radiation on DNA and RNA content in the rat hemispheres and cerebellum.
    Autorzy: Klimova Stefania, Misurova Eva
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.127-137, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • toksykologia
  • genetyka
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Effect of cadmium administration (3 mg CdCl2/kg body weight i.p.) and/or whole-body irradiation (3 Gy of gamma rays) on the rat brain was studied in the course of 21 d after treatment. The effect was studied on the basis of quantitative analyses of DNA and RNA. It was found that the changes of nucleic acids in the brain hemispheres were very slight and they lay in a temporal drease in DNA content on the 7th - 14th d after the irradiation alone and in combination with cadmium (CdCl2 administered 30 min before irradiation). In the cerebellum, the changes of nucleic acids were profound than in the hemispheres. The decrease in DNA content in the cerebellum was also only temporal and it occurred on the 1st d after the irradiation alone. The most interesting finding seems to be increase in DNA content in the cerebellun in a later period after the irradiation alone and in combination with cadmium without concomitant increase in RNA content. This finding suggests increasing number of cells with high nucleoplasmic ratio (mainly of cadmium administration on the rat brain was less expressed than effect of irradiation and combibation of the two treatments did not induce any summation effect.


    1819/2523

    Tytuł oryginału: Radioruthenium transfer into hen eggs after repeated administration.
    Autorzy: Rachubik Jarosław, Kowalski Bogdan
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.139-142, il., bibliogr. 12 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • ochrona środowiska
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • ptaki

    Streszczenie angielskie: Transfer of radioruthenium (Ru-106) into hen eggs was examined. Lying hens were administered daily with the radionuclide in drinking water for six days. During the entire study eggs were collected and radioactivity in their homogenised constituents was measured. At the beginning of the experimental period radioruthenium was slightly faster transferred into the albumen but later higher Ru-106 concentrations were recorded in the yolk. It is in contrast to our earlier observations that radiocaesium demonstrates stronger affinity for egg albumen.


    1820/2523

    Tytuł oryginału: Whole-body and organ retention of cadmium after repeated administration to rats.
    Autorzy: Grosicki Andrzej, Kowalski Bogdan
    Źródło: Bull. Vet. Inst. 2002: 46 (1) s.143-147, tab., bibliogr. 10 poz.
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Male Wistar rats were exposed to a water solution of cadmium chloride (labelled with cadmium-109) at a dose corresponding to 10 mg Cd/kg diet for 28 days. Carcass, hepatic, renal and testicle distribution of cadmium was studied for 32 days after dosing. Our results indicate that the carcass deposition of cadmium was at a comparative level during the experimental period. Hepatic distribution pattern of cadmium resembled that in the carcass. No substantial alterations in renal and testicle cadmium content were noted. The muscles demonstrated markedly different pattern of cadmium distribution in relation to the other organs; the highest levels were found till day 2 after dosing and decreased steadily thereafter. The liver, kidneys and muscles contained a substantial part (about 95 p.c.) of the total dose of cadmium.


    1821/2523

    Tytuł oryginału: Regional certification commission statement (speaking note; 15th meeting of the Commission: 21/6/02).
    Źródło: Prz. Epidemiol. 2002: 56 (4) s.511-514
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • neurologia
  • choroby zakaźne

    Typ dokumentu:
  • praca związana ze zjazdem
  • sprawozdanie
  • praca epidemiologiczna
  • tytuł obcojęzyczny


    1822/2523

    Tytuł oryginału: AIDS research in developing countries: Do the ends justify the means?
    Autorzy: Clark Peter A.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.ED5-ED16
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • aIDS

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Concrete ethical standards for human research are clearly stipulated in both international and national codes of ethics, and are meant to protect human subjects, especially the most vulnerable. A recent clinical study conducted from 1994 to 1997 by Dr. Thomas C, Quinn, M.D. has fueled the debate raging in the scientific community regarding the ethics of clinical AIDS research in developing countries. Quinn's conducted a community-based, randomized, controlled study of 15, 127 rural Ugandans to determine whether intermittent antibiotic treatment to reduce the prevalence of other sexually transmitted diseases would also reduce the rate of HIV transmission. Subsequently, the study identified 415 couples in which one partner was HIV positive and one was initially HIV negative and followed them prospectively for up to 30 months. Researchers were not permitted to inform the seronegative partner of the HIV status of the other partner. As a result, 90 of the initially HIV negative partners (21.7 p.c.) seroconverted during a follow-up period of 30 months. To allow for research studies in developing countries that are not permitted in the United states appears to make the Third Worl dequivalent to a'research sweat shop'. Developing nations offer easy access to patients, reduced costs, and less stringent regulations. This appears to create a double standard for medical research that is both ethically and humanly unacceptable, especially when other viable option exist. To allow relativism to seep into the international and national ethical standards will open the door to an idea that condones the possible abuse of those least able to rpotect themselves. Researchers have an ethical responsibility to uphold the integrity of these ethical standards. Failure to do so today may have a devastating impact on humanity in the future.


    1823/2523

    Tytuł oryginału: Repeated intravenous doses of all-trans-retinoyl á-D-glucuronide is not effective in the treatment of bacterial bronchopneumonia in lambs but is devoid of gross and acute toxicity.
    Autorzy: Gallup Jacek M., Grubor Branka, Barua Arun B., Mohammadi Gholamreza, Brogden Kim A., Olson James A., Ackermann Mark R.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR345-BR353, il., tab., bibliogr. 55 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • weterynaria
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: All-trans-retinoyl á-D-glucuronide, a water-soluble glucuronic acid conjugate of all-transretinoic acid, has demonstrated high biolobical activity and low toxicity in most in vitro and in vivo models. Since the reparative effects of retinoids on epithelium are well-known, our aim was to study the effect(s) of intravenously-administered all-trans-retinoyl á-D-glucuronide in lambs with chronic bacterial bronchopneumonia. Material/methods: Two groups of lambs were inoculated intrabronchially with either pyrogen-free saline or Mannheimia haemolytica. Thirty-three days later, lambs were injected four times at five-day intervals with 2 mL of 116 mM all-trans-retinoyl á-D-glucuronide (6.0-9.3 ćmol/kg or 2.86 - 4.42 mg/kg animal body weight) in dimethyl sulfoxide, or dimethyl sufoxide alone. Animal behavior and signs of clinical illness were logged daily. Lung and liver samples were assessed for histophatology, while serum and liver samples were extracted for retinoids and analyzed by reversed-phase gradient high-performance liquid chromatography. Results: Repeated injections of hibhly concentrated all-trans-retinoyl á-D-glucuronide did not cause changes in appetite, activity or other behaviors nor did it cause histologic lesions in liver and lung. However, it had no effect on resolution of lung lesions resultant of chronic Mannheimie haemolytica bronchopneumonia. Conclusion: Repeated intravenous administration of high amounts of all-trans-retinoyl á-D-glucuronide to lambs did not elicit signs of gross or microscopic toxicity. However, administering all-transretinoyl á-D-glucuronide too late in the progression of bacterial pneumonia is thought to be the main reson for its lack of effect in this model. A retinoid lactone derivative was detected in sheep serum and liver several days after treatment.


    1824/2523

    Tytuł oryginału: Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal funcitons in rats.
    Autorzy: Haleem Darakhshan J., Batool Farhat, Khan Nadia H., Kamil Noor, Ali Obaid, Saify Zafar S., Haleem Mohammad A.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR354-BR361, il., bibliogr. 51 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: An important goal of current neuroleptic research is to develop antipsychotic compounds with a low incidence of extrapyramidal side effects (EPS). Clozapine, the first of the atypical antipsychotics to be proven effective in treatment-resistant schizophrenia, is reported to produce less EPS than typical neuroleptics, such as haloperidol. Material/methods: The present study compares the neurochemical profiles of clozapine and haloperidol in rats. Animals injected (i.p.) with haloperidol or clozapine were sacrificed 1h later to collect brain samples. Neurochemical estimations were carried out by HPLC-EC. Results: Administration of haloperidol at doses of 1.0, 2.5 and 5.0 mg/kg increased the concentration of homovanillic acid (HVA), a metabolite of dopamine (DA), in the stratum and rest of the brain. Clozapine-injected rats (2.5, 5.0 and 10.0 mg/kg) showed smaller increases in the striatum, but not in the rest of the brain. Dihydroxyphenylacetic acid (DOPAC), another DA metabolite not affected by haloperidol, increased in teh striatum and decreased in the rest of the brain of clozapine-injected rats. 5-Hydroxyindoleacetic acid, the predominant metabolite of serotonin, increased with haloperidol and dereased with clozapine. A high dose of haloperidol (5.0 mg/kg) increased DA and 5-HT, while and equivalent does of clozapine (10.0mg/kg) decreased levels in the rest of the brain. The effects of both drugs on the HVA/5-HIAA and DOPAC/5-HIAA ratios were also different. Conclusions: THe differing activites of the two drugs at DA and serotonin receptors implies an important role for serotonin in treatment-resistant schizophrenia and a lower incidence of EPS.


    1825/2523

    Tytuł oryginału: Ischemic preconditioning diminishes oxygen demand and increases coronary flow in the early phase of reperfusion in rat heart.
    Autorzy: Rudziński Tomasz, Mussur Michał, Wawrzycki Marcin, Gwiazda Zbigniew, Zasłonka Janusz, Mussur Mirosław
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR362-BR368, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Ischemic preconditioning (IPC) can be defined as an adaptive mechanism induced by a brief period of reversible ischemia increasing the heart's resistance to a subsequent longer period of ischemia. The objective of our research was to describe the effects of IPC on the hemodynamic function and metabolism of the myocardium during postischemic reperfusion. Material/methods: 20 rat hearts were assigned to a preconditioning group (n = 10) or to a control group (n = 10). Preconditioning was achieved with 5 min. of global ischemia and 10 min. of reperfusion followed by 40 min. of ischemia. We investigated the postischemic recovery of aortic pressure, cardiac output, and coronary flow, as well as oxygen consumption, carbon dioxide release, and [H+] release. Results: No significant intergroup differences in aortic pressure and cardiac output were observed during reperfusion. In both groups, increased coronary flow (greater in the IPC group: 11.4 ń 0.6 ml/min. vs 9.1 ń 0.5 ml/min. in control group) was observed in the early phase of reperfusion. This was accompanied by a rise in CO2 and [H+] release, which was also greater in the IPC group. Oxygen consumption was significantly lower in the IPC group in the later phase of reperfusion (9.39 ń 0.53 vs 11.79 ń 0.54 ćmol/min/g dry weight), as were Co2 and [H+} release. Conclusions: IPC diminishes oxygen demand during reperfusion without changing the hemodynamic function considerably. IPC results in a transient increase of coronary flow accompanied by a rise in CO2 and [H+] release.


    1826/2523

    Tytuł oryginału: CFTR gene mutations in patietns suffering from acute pancreatitis.
    Autorzy: Kostuch Marzena, Rudzki Sławomir, Semczuk Andrzej, Kulczycki Lucas
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR369-BR372, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: The aim of our study was to investigate the frequency of the CFTR gene muatation in a selected group of patients suffering from severe acute pancreatitis. Material/methods: DNA isolated from peripheral blood samples from forty-one subjects was analyzed for the eight most common CFTR gene mutations (deltaF508, G542X, G551D, R553X, 1717-1(G A), W1282X, N1303K, delta1507) by the reverse-hybridization technique, suing INNO-LIPA CF2 test strips. The level of chloride ions in sweat samples was established using the pilocarpine iontophoresis method. Results: In the study group, none of the patients harbored CFTR gene mutations. In these selected cases, the experiments were repeated twice to ensure the reliability of the results. All of the subjects had a normal level of chloride ions (range 8-38 mmol/l). comparison with historical carriers revealed no differences between the frequency of carriers of the CFTR gene mutations in teh general Polish population (4 p.c.) in comparison with the surgical patients with acute pancreatitis (p = 0.26; Fisher exact test). Conclusion: We found no patietns with severe acute pancreatitis who had CFTR gene mutations, suggesting that these alterations are not a risk factor for the disease in our population. Further studies are warranted to evaluate the frequency and role of rarae ('mild') CFTR gene point mtuations in subjects suffering from severe acute pancreatitis.


    1827/2523

    Tytuł oryginału: Cytotxic effect of cyclosporin A alone and in combination with 2-chlorodeoxyadenosine against P388 murine leukemia in vivo.
    Autorzy: Józefowicz-Okonkwo Grażyna, Szmigielska-Kapłon Anna, Robak Tadeusz
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR373-BR377, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Background: THe purpose of our study was to determine the antileukemic effects of cyclosporin A (CsA0 and its interaction with a new purine analogue, -chlorodeoxyadenosine (2-CdA, cladribine) on P388 murine leukemia in vivo. Material/methods: Mice were engrafted intraperitoneally (i.p.) with 10**6 P388 leukemia cells on day 0 of each step of the two-step experiment. ALl treatments were initiated on teh next day (day 1) as daily i.p. injections and lasted for five consecutive days. In the first part of the experiment, designed to establish the antileukemic effect of CsA, the mice received 10, 15, 20, 25 or 30 mg/kg of CsA. In the second part, where the interaction between CsA and 2-CdA was examined, the animals were administered CsA at a dose of 15 mg/gk, or 2-CdA at a dose of 20 mg/kg, or CsA combined with 2-CdA at the same doses as in monotherpay. Results: CsA did not influence the survival time of mice with P388 leukemia at any dose. ScA was used for the interaction study at a dosage of 15 mg/kg, as this was best tolerated by the animals. The mice treated with combination therapy using CsA and 2-CdA survived longer than those treated with 2-CdA monotehrapy (p = 0.00015). Conclusion: Our study revealed that CsA alone does not increase the survival time of mice with P388 leukemia, but it augments the antileukemic effect of 2CdA.


    1828/2523

    Tytuł oryginału: Chronic alpha1-adrenergic blockade improves hypertension and renal injury in L-NAME and low-renin L-NAME-DOCA hypertensive rats.
    Autorzy: Wangesteen Rosemary, O'Valle Francisco, Moral Raimundo G. Del, Vargas F‚lix, Osuna Antonio
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR378-BR384, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: The present study investigated the contribution of ŕ1-adrenergic blockade to hypertension induced by long-term blockade of nitric oxide and chronic treatment with deoxycorticosterone acetate (DOCA), which produced a low renin model of hypertension. We studied the effects of chronic administration of prazosin, an ŕ1-receptor antagonist, on blood pressure (BP), renal injury, and other variables in Nomega-nitro-L-arginine methyl ester (L-NAME) and L-NAME+DOCA hypertensive rats. Material/methods: The rats were divided into 6 groups: Control, DOCA, L-NAME, L-NAME+DOCA, L-NAME+prazosin, and L-NAME+DOCA+prazosin. Tail systolic BP was measured twice a week. After a 6-week evolution, mean arterial pressure (MAP) was measured, along with selected metabolic, morphological and renal variables. Results: The final MAP values were 105 ń 1 for Control, 107 ń 0.6 for DOCA, 153 ń 3 for L-NAME, 175 ń 2 for L-NAME+DOCA, 126 ń 2 for L-NAME+prazosin and 127 ń 5 for L-NAME+DOCA+prazosin. Proteinuria and hyaline arteriopathy were prevented in L-NAME+prazosin rats and markedly attenuated int eh L-NAME+DOCA+prazosin group. Plasma urea and creatinine were significantly increased in teh L-NAME+DOCA group, but not in the L-NAME+DOCA+prazosin group as against controls. The DOCA and DOCA+L-NAME groups showed relative renal and cardiac hypertrophy, which was not observed in teh DOCA+L-NAME+prazosin group. Cocnlusions: ŕ1-adrenergic tone plays and important role in the increased BP and renal injury of L-NAME hypertension. Our results also indicate that when PRA is suppressed by DOCA in L-NAME hypertension, the increased BP and renal injury are largely dependent on the ŕ1-adrenergi tone.


    1829/2523

    Tytuł oryginału: Skin rubdown with a dry towel activates natural killer cells in bedridden old patients.
    Autorzy: Iwama Hiroshi, Akama Yoichi
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR611-CR615, il., tab., bibligor. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Skin rubdown using a dry towel to scrub the whole body is a traditional procedure. Because massage therapy is effective in improving cellular immunity, skin rubdown may also have the similar effects. Material/methods: Sixteen bedridden old patients, who had suffered a cerebral stroke, were studied. Skin rubdown for about 10 minutes was added for 10 days. Blood was collected at noon on the day before skin rubdonw, 5 and 10 days after initiation and 5 days after completion, and the neutrophil count, lymphocyte count, serum gamma-globulin and C-reactive protein (CRP) levels and natural killer cell activity were measured. In 9 of these 16 patients, B, T, CD4 and CD8 lymphocyte counts were additionally measured on the same days. Reslults: There were no significant changes in teh time course of the lymphocyte count, gamma-globulin or CRP levels. The neutrophil count increased 10 days after initiation of the skin rubdown, and natural killer cell activity increased 5 and 10 days after initiation, and returned to the baseline level 5 days after completion. Although there were no changes in the time course of the B, T, CD4 and CD8 lymphocyte counts, the CD4/CD8 ratio showed an increase 5 days after initiation and completion. Conclusions: Skin rubdonw activates natural killer cells, which may be attributed to the effect of certain mediators released from teh T lymphocytes and/or the stimulated effect on the sympathetic nerves. The technique may be used to reduce a variety of complications caused by the decreased immunity observed in bedridden old patients.


    1830/2523

    Tytuł oryginału: Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis.
    Autorzy: Pache Mona, Schwarz Hans A., Kaiser Hedwig J., West Peter, Kl”ti Manuel, Dubler Barbara, Flammer Josef
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR616-CR619, il., bibliogr. 15 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Contradictory results on plasma endothelin-1 (ET-1) levels in patietns with rheumatoid arthritis have been reported in previous studies. We therefore evaluated whether plasma ET-1 levels in patients with rheumatoid arthritis differ from those of normal controls. Since systemically increased levels of ET-1 are known to occur in tandem with primary or secondary vascular dysregulation, we also measured peripheral blood flow by means of nailfold capillaroscopy combined with a cold provocation test. Material/methods: We measured plasma levels of ET-1 in twelve patients with different stages of rheumatoid arthritis by means of a specific radioimmunoassay, and compared ET-1 values to those of healthy controls. Capillary blood flow and the frequency of cold-induced vasospasm were studied in parallel, using nailfold capillaroscopy combined with a cold provocation test. Results: Plasma ET-1 levels were significantly increased in patietns with rheumatoid arthritis (p = 0.01) when compared to controls (2.38 ń 0.95 pg/ml vs. 1.53 ń 0.38 pg/ml). Capillary blood flow was reduced when compared to our own normal values, and a cold-induced blood standstill was seen in 58 p.c. of the patients. Conclusion: Patients with rheumatoid arthritis exhibit significantly elevated levels of ET-1, which may be associated with the symptoms of vascular dyregulation observed in nailfold capillaroscopy. Even though the clinical conclusions should be drawn from this study with caution, additional therapy with calcium channel blockers or, possibly in the future, with ET-1 receptor blockers, may be benficial in patients with rheumatoid arthritis.


    1831/2523

    Tytuł oryginału: Resistance mutations in HIV-infected patietns experiencing early failure with nelfinavir-containing triple combinations.
    Autorzy: Nuńez Marina, Mendozaut. Carmen de, Valer Luisa, Casas Esperanza, López-Calvo Soledad, Castro Angeles, Rosón Beatriz, Podzamczer Daniel, Rubio Amalia, Berenguer Juan, Soriano Vincent
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR620-CR623, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • aIDS
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: The purpose of our study was to assess the presence of nelfinavir (NFV)-associated resistance mutations at the time of early virological failure in subjects receiving NFV as part of a first protease inhibitor (PI)-based triple regimen. Material/Methods: Subjects failing their first PI-based NFV-containing triple regimen were identified in six Spanish hospitals. HIV genotyping was carried out in plasma samples collected at the time of the first viral rebound. Results: Upon initiation of NFV-based therapy, 19 of the 30 subjects (63 p.c.) werena‹ve; 11 (37 p.c.) had been exposed to nucleoside analogues. Median HIV-RNA at the time of viral rebound was 4, 180 copies/ml. PCR-amplified products were obtained in 22 subjects (73 p.c.). These products were sequenced and primary PI resistance mutations were recognized in 6 patietns (27 p.c.). All six individuals harbored the D30N mutation, and none presented the L90M mutation. Other PI resistance mutations were present in 5 subjects (at codons 36, 63, 71, 77, 82 and/or 88). Secondary PI resistance mutations were present in another 9 subjects. By contrast, mutations conferring resistance to reverse transcriptase nhibitiors were present in 50 p.c. of the patietns, and the M184V substitution was the most frequently seen. Conclusions: Nearly 75 p.c. of patietns failing their first PI-based triple regiment containing NFV do not harbor PI resistance mutations. THe D30N substitution, rather than L90M, is the msot frequently recognized, which does not challenge the efficacy of further rescue interventions with other PIs. This observation supports the use of nelfinavir as first protease inhibitor.


    1832/2523

    Tytuł oryginału: Detection and genotyping of astroviruses from children with acute gastroenteritis from Goiƒnia, Goias, Brazil.
    Autorzy: Divina das D“res de Paula Cardoso, Souza Fiaccadori Fabiola, Borges de Lima Dias e Souza Menira, Bringel Martins Regina Maria, Gagliardi Leite Jos‚ Paulo
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR624-CR628, tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.

    Streszczenie angielskie: Background: The astroviruses constitute important agents of childhood diarrhea. The purpose of our research was to detect and genotype astroviruses in fecal samples from children with acute gastroetneritis from Goiania-Goias, Brazil. Material/Methods: The samples were collected from children up to five years of age with acute gastroetneritis, hosptialized in two public hospitals in Goiania-Goias, a city located in teh West Central region of Brazil. A total of 516 fecal samples were collected from March 1998 to March 2000. These samples were first screened for rotavirus and adenovirus by an enzyme immunoassay (EIARA) and by PAGE for the detection of rotaviruses. In all samples negative for both viruses (n - 351) the presence of astrovirus was investigated by reverse-transcription-polymerase chain reaction (RT-PGR). Results: 2.8 p.c. of the samples obtained from children up to two years of age were positive for astrovirus by RT-PCR, with an expected amplicon size of 449 bp. All positive samples, except one, were collected between October and December of 1998, which corresponds to the rainy season in the region (spring/early summer). Nested-PCR genotyping showed that all samples were genotyped and belonged to astrovirus genotype 1, presenting an amplicon band pattern of 212 bp. Conclusions: This study supports data from the literature about the occurrence of astrovirus in children with acute gastroenteritis. It also helps provide a better understanding of viral etiology in diarrhea.


    1833/2523

    Tytuł oryginału: Physiological assessment of the function of the ileocecal junction with evidence of ileocecal junction reflexes.
    Autorzy: Shafik Ahmed, El-Sibai Olfat, Shafik Ali A.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR629-CR635, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The ileocecal junction (ICJ) appears to be a specialized segment of the gut which regulates the passage of the chyme from the ileum to the cecum. We investigated the response of the ICJ to cecal and ileal distension and the nature of this response (direct or reflex). Material/Methods: Nine patients who had early cancer in the proximal transverse colon were studied during right hemicolectomy. The pressure response of the ICJ to cecal and ileal balloon distension was determined before and after cecal and ileal anesthesia. The balloon and manometric catheters were introduced into the cecum and ileum by colotomy and ileotomy, respectively ICJ length was measured by the pull-through technique. Results: The ICJ high pressure zone had a mean length of 3.6 cm. Chyme flow to the cecum occurred in jets. Large-volume cecal distension caused a significant rise in cecal and ICJ pressures and decreased ileal pressure; the balloon was dispelled to the transverse colon. Large-volume ileal distension caused an increase in ileal pressure, decreased ICJ and cecal pressures, and aboral balloon movement. No pressure response was produced by small volume distension or anesthesia of the cecum or ileum. Conclusions: Ileal distension is suggested to initiate reflex ICJ and cecal relaxation which is mediated through the 'ileocecal inhibitory reflex' and which allows the chime to pass to the cecum. Cecal distension appears to evoke reflex ileal and ICJ contraction, thus preventing ceco-ileal reflux and allowing time for chyme to accumulate in, and distend, the terminal ileum; we call this reflex the 'ceco-ileal excitatory reflex'. These 2 reflexes are thought to regulate chyme passage through the ICJ.


    1834/2523

    Tytuł oryginału: Coronary artery anomalies in adult patients.
    Autorzy: G”l Mehmet Kamil, ™zatik Mehmet Ali, Kunt Aysegl, Iscan Zafer, Yavas Soner, Soylu Mustafa, Korkmaz Sule, Tasdemir Oguz
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR636-CR641, tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Coronary artery anomalies are discovered in less than 1 p.c. of angiography series. Since the number of angiographies and coronary bypass operations are increasing significantly every day, these anomalies are of clinical importance. Material/Methods: 58.023 coronary angiographies were performed in the cardiology clinic of our hospital from 1978 to 2001. Coronary artery anomalies were discovered in 257 of these cases (0.44 p.c.). The mean age of these patients was 51.9 ń 11.4 years (18-82). 80 p.c. were male (n = 207). Results: The circumflex artery (CXA) was the most frequently involved vessel (51.1 p.c.). Coronary arteries originating from the pulmonary artery were not encountered in our series due to the natural history of the disease. In 54 patients with coronary artery fistulae, 18 (33.3 p.c.) were closed by operation. Perioperative mortality was 5.5 p.c. Acquired coronary artery fistulae or aneurysms due to trauma or inflammatory diseases are completely different entities and beyond the scope of this article. In 76 patients, open heart surgery was required for additional lesions, 57 of which were coronary artery bypass grafts. Conclusions; Being usually asymptomatic, coronary artery anomalies are usually discovered incidentally in the adult population. These pathologies are important for practical purposes, especially for interventional cardiologists, radiologists and cardiac surgeons, who should be aware of these anatomical entities. LMCA originating from the right coronary system has been reported to result in sudden death and myocardial ischemia, so these mostly asymptomatic patients must be followed closely.


    1835/2523

    Tytuł oryginału: Borna Disease Virus - reactive antibodies in Polish psychiatric patients.
    Autorzy: Rybakowski Filip, Sawada Takashi, Yamaguchi Kazunari, Rajewski Andrzej, Rybakowski Janusz
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR642-CR646, tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: It has been proposed that the Borna Disease Virus (BDV) plays a role in the etiopathogenesis of psychiatric disorders. We assessed BDV seropositivity in Polish psychiatric patients and healthy controls, and the relationship between seropositivity and selected diagnostic and clinical variables. Material/Methods: Serum samples from 946 psychiatric patients with different diagnoses (ICD-10) and 407 psychiatrically healthy controls were assayed. The ECLIA method was used, which enables the assessment of two anti-BDV antibodies: anti-p24 and anti p-40. Data were also collected on diagnosis, age, age at onset, and place of residence. Results: Only anti-p24 antibodies were found. The seropositivity rates were: 2.4 p.c. and 1.0 p.c., respectively, in patients and controls (p = 0.1). A significant difference between patients and controls was observed in mental retardation and affective-anxiety spectrum disorders. Seropositivity did not show any association with demographic variables, but it was elevated in patients with recent onset of disease vs. remote onset of disease (10.2 p.c. vs. 1.6 p.c.; p = 0.0003). Conclusions: Significantly higher anti-BDV seropositivity was found in Polish psychiatric patients with affective-anxiety spectrum disorders and mental retardation than in controls. The association between recent onset disorders and higher anti-BDV response, in the light of recent reports on circulating immune complexes of BDV antigens and antibodies, warrants furhter studies on the longitudinal course of humoral response to BDV.


    1836/2523

    Tytuł oryginału: Contemporary coronary intervention in bifurcation lesions - two-year follow-up in an unselected cohort.
    Autorzy: Dudek Dariusz, Legutko Jacek, Zymek Paweł, Kałuża Grzegorz L., Dubiel Jacek S.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR647-CR651, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Optimatization of coronary angioplasty in bifurcation lesions remains a major challenge for percutaneous revascularization techniques. Material/Methods: We evaluated procedural success, major in-hospital complications, target vessel revascularization, and 2-year clincial outcomes in 45 patients who underwent PTCA of a bifurcation lesion using currently available techniques and rigorous criteria for optimal immediate result. Results: Angiographic success occurred in 100 p.c. of the parent vessels and in 84.4 p.c. of both vessels. Within the first 24 hours, there were no deaths or Q-wave myocardial infarction. Three non-Q-wave myocardial infarctions occurred (6.6 p.c.) and one emergency PTCA was necessary (2.2 p.c.). Therefore, clinical success was achieved in 91.2 p.c. of these patients. At 2-year follow-up, 3 cardiac deaths had occurred, the target revascualarization rate was 20 p.c., and the total frequency of major adverse cardiac events (MACE) was 37.8 p.c. Conclusions: Optimization of coronary angioplasty in bifurcation lesions is possible and results in a high angiographic success rate, low risk of acute complications and acceptable long-term clinical outcomes. However, the fairly high incidence of MACE at 2 years suggests that bifurcation lesions remain a challenge in everyday practice despite contemporary intervention methods and the use of GPIIb/IIIa inhibitors.


    1837/2523

    Tytuł oryginału: Influence of the hepatocellular damage on the clinical usefulness of biochemical markers of bone matabolism and parathormon in haemodialysed patients.
    Autorzy: Jaroszyński Andrzej J., Książek Andrzej, Załuska Wojciech
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR652-CR656, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • gastroenterologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The present study was undertaken to determine if hepatitis C virus (HCV) and cytomegalovirus (CMV) infections, as well as biochemical indices of liver damage, can significantly influence the relationships occurring between markers of bone formation, resorption and PTH in hemodialysis patients. Material/Methods: 76 HD patients were tested for anti-HCV and anti-CMV antibodies. Serum intact PTH osteocalcin, total and bone isoenzyme of alkaline phosphatase, and plasma tartrate-resistant acid phosphatase were determined as bone metabolism indices. Serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (ć-GT) were measured as markers of hepatocyte function. The patients were divided into subgroups according to serological and enzymatic status. Results: 37 patients were anti-HCV positive, 61 were anti-CMV positive, and 35 were both anti-HCV and anti-CMV positive. 13 patients were free of viruses. Elevated ALT and ć-GT activity was found in 26 and 15 patients respectively. Indices of bone formation, resorption and pTH values showed no signficance differences in the respective subgroups. markers of bone formation significantly correlated with one another, as well as markers of bone resorption and intact PTH in all patients. In the subgroup of patients with increased ć-GT activity, significant differences were found in the slopes of the regression lines occurring in most of the estimated correlations in comparison with all other subgroups. Conclusions: In renal osteodystrophy, hepatocellular damage indicated by an increase of ć-GT influences the relationship between the biochemical markers of bone metabolism and parathormone levels, but the presence of anti-HCV and anti-CMV antibodies does not.


    1838/2523

    Tytuł oryginału: Heparin reduces oxidative stress in the postoperative period.
    Autorzy: Dzieciuchowicz Łukasz, Chęciński Paweł, Krauss Hanna
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CR657-CR660, tab., bibligor. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: The purpose of our study was to investigate the influence of low-dose heparin on peroxide levels and the antioxidant activity of superoxide dysmutase (SOD), catalase (CAT), and glutathione peroxidase in the red blood cells of patients undergoing minor abdominal surgery. Material/Methods: 49 patients scheduled for open cholecystectomy, with a median age of 43, were randomly assigned to either the heparin group (HG) or the placebo group (PG). HG patients received a subcutaneous dose of 100 IU/kg body weight of standard heparin for 6 days, beginning the first day after surgery. On the day prior to surgery and on the 1st, 2nd and 6th postoperative days, blood samples from peripheral veins were collected, and the levels of peroxides, superoxide dysmutase (SOD), catalase (CAT) and glutathione peroxidase activity in the hemolysate of red blood cells were determined. The level of malondialdehyde was also measured. Results: Signifciantly lower levels of peroxides, as well as higher antioxidant activity of SOD and CAT, was found in the erythrocytes of HG patients. Heparin adminisitration did not significantly influence the activity of glutathione peroxidase. There were also no differences in the levels of malondialdehyde between HG and PG patients. Conclusions: Low-dose standard heparin administered subcutaneously in patients undergoing minor abdominal surgery shows an antioxidant effect. Furhter studies are required to clarify the mechanism of increased SOD and CAT activity in red blood cells induced by heparin.


    1839/2523

    Tytuł oryginału: GI Anthrax: report of one case confirmed with autopsy.
    Autorzy: Mansour-Ghanaei Faribourz, Zareh Shahab, Salimi Arezoo
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.CS73-CS76, il., bibliogr. 15 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Bacillus Anthraces is a non-motile, rod like, gram-positive and aerobic bacillus that produces central oval-shaped spores and characterized by rough, irregular and often comma-shaped colonies in blood agar. About 95 p.c. of human anthrax is cutaneous and 5 p.c. respiratory. GI anthrax, a very rare type, has been reported in less than 1 p.c. of all cases. We thus report a case of GI anthrax with autopsy findings. Case report: A 15-year-old young adult man was admitted to our hospital with history of fever, abdominal pain and bloody diarrhea from 48 hours after ingestion of half-cooked sheep's meat. In endoscopic exam of upper GI tract, the esophagus had been filled with fresh blood without any varices, stomach showed evidence of hemorrhage and had multiple erosion but no ulceration of duodenum. Penicillin G 24,000,000 U/day IV was started but unfortunately severe upper an lower GI hemorrhage developed, leading to hypotension and death. In autopsy, ascites, paraaortic and mesenteric lymphadenopathy was accident with some of them being hemorrhagic. The spleen was slightly enlarged with hemorrhagic congestion in some parts of it. In the blood sample drawn from the spleen, the filamentous bacillus was successfully found. Conclusions: Because of the fatal nature of the disease and the similarity of the signs and symptoms to the other gastrointestinal diseases, we should consider it as one of the probable differential diagnosis in the patients with upper and lower gastrointestinal bleeding with fever esp. in the endemic areas.


    1840/2523

    Tytuł oryginału: Biological rhythms and behavior - then and now.
    Autorzy: Appenzeller Otto, Corn‚lissen Germaine, Halberg Franz, Wallace James, Costa Maria A.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.SR27-SR30, il., bibliogr. 6 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca historyczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • historia starożytności

    Streszczenie angielskie: Background: Living matter has its own 'biological time': a set of rhythmic oscillations, paced by genes whose expression varies over regular cycles. The resulting chronomes, or time structures, are usually studied in living matter. A human chronome is preserved long after death in the structure of tooth enamel. This fossil record can be compared with contemporary enamel thus providing insight into an ancient biological rhythm, and consequently into behavior in pre-historic civilizations. Material/Methods: Eight adult 3rd molar teeth from human burials in Atacama oases of Northern Chile, dating from AD 400 to 900 and belonging to the pre-Hispanic San Pedro culture, were compared to 20 discarded contemporaneous teth from Albuquerque, N. M. USA. Two adjacent, 100 ćm thick ground sections from each tooth were examined using a stereoscopic dissecting microscope and polarized light. The intervals between consecutive brown striae of Retzius (TBS) and the width of the enamel were measured. We recorded the the number of TBS and the number of Wilson's bands and calculated a ratio of enamel with/number of TBS for each section. We used ANOVA for statistical analysis and cosinor methodology for chronomics, time structure (chronome) mapping. Results: The 'biological week' in the chronome (time structure) of ancient enamel, gauged by TBS, varied according to a multiseptan (multiple of seven) component faster than did the multiseptan of contemporaneous teeth (1/2.7 versus 1/4.6 biological weeks). Conclusions: Until now no human chronome has been isolated from fossilized structures. Our discovery indicates that behavior of ancient populations, such as rest and work spans, can be deduced to some extent after millennia.


    1841/2523

    Tytuł oryginału: Etoposide added to weekly leucovorin (LV)/5-fluorouracil (5-FU) in LV/5-FU pre-treated patients with advanced colorectal cancer.
    Autorzy: Tsavaris Nicolas, Kosmas Christos, Gennatas Kostas, Vadiaka Maria, Paliaros Platon, Dimitrakopoulos Antonis, Diamantis Theodoros, Tsipras Heraklis, Papastratis George
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.PI65-PI69, bibliogr. 33 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • toksykologia
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: We evaluated the efficacy and safety of the weekly combination of etoposide, leucovorin (LV) and 5-fluorouracil (5-FU) when administered as second-line chemotherapy in patients with relapsed/refractory advanced colorectal cancer (ACC), previously treated with weekly LV+5-FU. Material/Methods: Etoposide was administered at 3 different dose levels (DL), in 3 groups of patients (Total - 60); DL-I - etoposide 80 mg/mý, 45 min i.v. infusion, DL-II - etoposide 120 mg/mý, and DL-III - etoposide 180 mg/mý. In all three levels etoposide was followed by LV 100 mg/mý i.v., 1-hour infusion, and 5-FU 500 mg/mý i.v. bolus. Treatment was adminsitered until disease progression or unacceptable toxicity. Results: No patients responded at DL-I, while 2 patients at DL-II and 3 at DL-III had a partial response (PR) (P 0.1). Two patients had stable disease (SD) at DL-I, 8 at DL-II, and 9 at DL-III (P 0.01). More patients progressed at DL-I (n = 19) compared to DL-II (n - 10) and DL-III (n = 8) (p 0.0007). The time to progression was 17, 15, and 14 weeks, respectively, for DL-I, -II, and -III (P = 0.9). Median survival was 30, 30, and 32.5 weeks, respectively, for DL-I, -II, and -III (P = 0.27). Toxicity was mainly neutropenia, diarrhea and mucositis at all DLs, significantly more intense in DL-III. No difference was noticed in responses between DL-II and DL-III, but toxicity in DL-III was more severe. Conclusions: The combination of etoposide with LV+5-FU has limited activity when adminsitered after failure of weekly LV+5-FU in patients with ACC.


    1842/2523

    Tytuł oryginału: Clinical and pharmacokinetic study of fractionated doses of oral etoposide in pediatric patients with advanced malignancies.
    Autorzy: Gregianin Lauro J., Brunetto Algemir L., Leone Luciane Di, Costa Teresa Dalla, Santos Pedro P., Schwartsmann Gilberto
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.PI70-PI77, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • pediatria
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Background: The purpose of this phase I study was to evaluate the toxicity profile, dose-limiting toxicities (DLT), maximum tolerated dose (MTD), and plasma pharmacokinetics of oral etoposide, and to recommend a safe fractionated dose for phase II trials in pediatric patients with refractory solid tumors. Material/Methods: All patients had tumors no longer amenable to established forms of treatment. The initial dose of etoposide was 20 mg/mý TID for 14 days every 21 days (dose-level I). Etoposide plasma pharmacokinetics were studied on day 1 of treatment and determined by PHLC. Results: Seventeen children were enrolled, 13 of whom were included in the pharacokinetic study, for a total of 64 courses. nine patients were included at dose-level I; grade 2-3 leucopenia was observed in 5. The dose was then raised to 25 mg/mý (dose-level II) in another 8 patients; grade 3-4 leucopenia was observed in 4. This dose-level was therefore considered the MTD. The DLT was neutropenia. In patients at dose-level I and II the maximum plasma etoposide concentration was 2.97 and 8.59 ćg/ml, respectively. Drug levels 1 ćg/ml were maintained for about 6.3 hours following drug administration at both dose-levels. Partial response was observed in 1 patient and 4 patients showed stable disease. Conclusions: Prolonged oral etoposide was well tolerated by our patients. Considering the MTD, and fact that the patients included at dose-level I achieved an adequate ( 1 ćg/ml) plasma concentration of etoposide for a sufficient time, this dose level was recommended for phase II studies in pediatric malignancies...


    1843/2523

    Tytuł oryginału: Effect of hormone replacement therapy with femoston on hemostasis in peri- and postmenopausal women.
    Autorzy: Repina Margarita A., Korzo Tatyana M., Zinina Tatyana A.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.PI78-PI84, tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Postmenopausal women are at increased risk of cardiovascular disease. Exogenous estrogens may potentially lower the risk of cardiovascular disease through beneficial changes in lipoprotein profile and hemostasis. The effect on the vascular system of combined estrogen/progestagen hormone replacement therapy is less clear. Material/Methods: A group of 44 peri- and postmenopausal women was studied during treatment with Femoston, a sequentially combined hormone replacement therapy consisting of 17-á-estradiol and dydrogesterone. Comparative analyses were made between the estrogen-only phase and the combined phase of the hormone replacement therapy. Comparisons were also made against the different phases of the spontaneous menstruation cycle in 10 pre- and perimenopausal controls. Results: Femoston had a neural effect on blood coagulation factors and had no effect on plasma glucose concentrations. With Femoston, there was a positive change in the atherogenic index and the total cholesterol/HDL cholesterol ratio. Conclusion: The findings from the present study provide evidence for the efficacy of Femoston hormone replacement therapy in terms of control of hemostasis and inducement of a potentially beneficial lipoprotein profile, which is important for reducing the risk of vascular pathology in periand postmenopausal women.


    1844/2523

    Tytuł oryginału: Simultaneous virtual representation of both vascular and neural tissue within the subarachnoid space of the basal cistern - technical note.
    Autorzy: Freudenstein Dirk, Wagner Alexandra, Grvit ™zlem, Bartz Dirk, Duffner Frank
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.MT153-MT158, il., bibliogr. 45 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna
  • praca techniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: The representation of different anatomical structures requires varying imaging modalities and protocols. By mental composition of single-slice images, a three-dimensional (3D) impression can be achieved. However, this presupposes an outstanding imagination and is subject to inaccuracies. The use of an interactive and multi-modal planning system which represents different data sets in one single virtual environment holds promise to facilitate and improve neurosurgical decision-making. The authors report the clinical application of a self-developed virtual planning system in a case of trigeminal neuralgia due to an ectatic basilar artery. Material/Methods: We modified our virtual planning system (VIVENDI), to achieve a virtual representation of the basal cistern illustrating both vascular and neuronal information. After conducting several experiments to determine an appropriate scanning protocol, we matched the data achieved by magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). Results: The system provides the vascular topography combined with information on the anatomical structure of the subarachnoid space. To illustrate the clinical usefulness of this planning approach, the authors present a case of trigeminal neuralgia caused by an ectatic basilar artery. Pre-operatively, the virtual representation returned accurate information on the anatomical configuration of the cerebellopontine angle and the course of the ectatic vessel. This information was confirmed during surgery...


    1845/2523

    Tytuł oryginału: Thyrotropin receptor antibodies detected by the human recombinant TBII assay - a surrogate marker for autoimmune activity in Graves' ophthalmopathy?
    Autorzy: Myśliwiec Janusz, Krętowski Adam, Stępień Agnieszka, Mirończuk Katarzyna, Kinalska Ida
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.MT159-MT162, il., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • okulistyka
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Recently a new very sensitive and specific commercial method for detection of TSHR-Ab bas become available: TBII assay using human recombinant TSHR. The aim of this study was to assess the potential of this novel TBII assay as a guideline for immunosuppressive therapy in patients with Graves' ophthalmopathy (GO). Material/Methods: We detected serum TBII level in three groups of subjects: 17 patients with clinical symptoms of GO, 14 patients with Graves' disease without ophthalmopathy (Gd), and 13 healthy volunteers. Corticosteroid therapy consisted of intravenous infusions of methylprednisolone (MP) and subsequent treatment with oral prednisone (P). Serum samples were collected 24 hours before MP, 24 hours after MP, after 14 days of P treatment and after the end of corticosteroid therapy. Results: The levels of TBII were significantly increased in both GO and Gd individuals as compared to the controls (p 0.001 and p 0.01 respectively). There was also a signficant difference in serum TBII between GO and Gd patients (p 0.01). We observed elevated pretreatment TBII serum levels in corticosteroid-resistant individuals as compared to corticosteroid - responsive patients. Corticosteroids caused a signficiant decrease in TBII serum levels in GO patients. Conclusions: The lack of clinical improvement despite decreased TBII level in our study suggests that the humoral immune response is not crucial in the pathogenesis of early GO. However, measurement of TSHR-Ab by the novel h-TBII assay may have prognostic value in the treatment of patients with severe GO as a surrogate marker of autoimmune activity.


    1846/2523

    Tytuł oryginału: Interaction of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAID) on gastric mucosa and risk of ulcerations.
    Autorzy: Konturek Peter C., Konturek Stanisław J., Cześnikiewicz Marta, Płonka Małgorzata, Bielański Władysław
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.RA197-RA209, il., bibliogr. 57 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Hp and NSAID are the most common pathogens in the stomach, but their interaction on gastro-duodenal mucosa has been little studies. Hp infection in humans does not interfere with NSAID-induced gastric ulcer healing by omeprazole, therefore, there is no rationale to eradicate the germ. Hp infection induces COX-2 expression resulting in excessive biosynthesis of gastroprotective prostaglandin (PG), which should in turn counteract NSAID-induced gastropathy and contribute to healing of existing ulcers. Some investigators claim that Hp infection acts synergistically with NSAID on ulcerogenesis and propose that Hp should be eradicated, particularly at the onset of long-term NSAID therapy. Our studies in about 6500 dyspeptic patients undergoing upper endoscopy and 13C-urea breath test revealed that about 70 p.c. of these patients are Hp positivie and 31 p.c. of these develop gastro-duodenal ulcers. Of these ulcers, 66 p.c. were Hp positive and NSAID negative, 3 p.c. - NSAID positive and Hp negative, 8 p.c. were both Hp positive and NSAID positive, while 23 p.c. ulcers were Hp and NSAID negative. An evidence was obtained for negative interaction between Hp infectio and NSAID on risk of gastro-duodenal ulcers suggesting that Hp may attenuate the peptic ulcerogenesis. Our results support the concept 1) the interaction between Hp infection and NSAID on gastro-duodenal ulcerations is antagonistic, 2) the Hp and NSAID are independent risk factors for peptic ulcerations in humans, 3) there is no need for the Hp eradication in NSAID-treated patients, and 4) the rate of ulcer complications (hemorrhage and perforation) remains constant despite the decrease in Hp and ulcer prevalence.


    1847/2523

    Tytuł oryginału: Superoxide dismutase - applications and relevance to human diseases.
    Autorzy: Noor Rana, Mittal Sonali, Iqbal Jawaid
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.RA210-RA215, bibliogr. 63 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Reactive oxygen species, such as superoxide radicals, are thought to underlie the pathogenesis of various diseases. Almost 3 to 10 p.c. of the oxygen utilized by tissues is converted to its reactive intermediates, which impair the functioning of cells and tissues. Superoxide dismutase (SOD) catalyzes the conversion of single electron reduced species of molecular oxygen to hydrogen peroxide and oxygen. There are several classes of SOD that differ in their metal binding ability, distribution in different cell compartments, and sensitivity to various reagents. Among these, Cu, Zn superoxide dismutase (SOD1) is widely distributed and comprises 90 p.c. of the total SOD. This ubiquitous enzyme, which requires Cu and Zn for its activity, has great physiological significance and therpaeutic potential. The present review describes the role of SODs, especially Cu, Zn SOD, in several diseases, such as familal amyotrophic lateral sclerosis (FAL), Parkinson's disease, Alzheimer's disease, dengue fever, cancer, Down's syndrome, cataract, and several neurological disorders. Mutations in the SOD1 gene cause of familal form of amyotrophic lateral sclerosis. The mechanism by which mutant SOD1 causes the degeneration of motor neurons is not well understood. Transgenic mice expressing multiple copies of FALS-mutant SOD1s develop and ALS-like motor neuron disease. Vacuolar degeneration of mitochondria has been identified as the main pathological feature associated with motor neuron death and paralysis in several lines of FALS-SOD1 mice. Various observations and conclusions linking mutant SOD1 and FALS are discussed in this review in detail.


    1848/2523

    Tytuł oryginału: The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.
    Autorzy: Daniel W[ładysława] A., Syrek M., Haduch A.
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (5) s.371-377, il., tab., bibliogr. s. 376-377
    Sygnatura GBL: 313,361

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • in vitro

    Streszczenie angielskie: The aim of the present study was to determine optimum conditions for studying promazine and perazine metabolism in rat liver microsomes and to investigate the influence of specific cytochrome P-450 inhibitors on 5-sulfoxidation and N-denmthylation of these neuroleptics. Based on the developed method, the metabolism of neuroleptics in liver microsomes was studied at linear dependence of product formation on time, and protein and substrate concentrations (incubation time: 10 min; concentration of microsomal proteins; promazine - 0,7 mg ml-1, perazine - 0,5 mg ml-1, substrate concentrations, promazine - 25,40 and 75 nmol ml-1, perazine- 20, 35, 50 mmol ml-1). A Dixon analysis of the metabolism of neuroleptics showed that quinine (a CYP2D1 inhibitor), metyrapone (a CYP2B1/B2 inhibitor) and ŕ-naphthoflavone (a CYP1A2/2 inhibitor) affected, whereas erythromycin (a CYP3A inhibitor) and sulfaphenazole (a CYP2C inhibitor) did not change the neuroleptic biotransformation. N-Demehtylation of promazine was competitively inhibited by quinine (K1=20 ćM) and metyrapone (K1=83 ćM), while of perazine - by quinine (K1=46.5 ćM), metyrapone (K1=46 ćM) and ŕ-napthoflavone (K1=78.8 ćM). 5-Sulfoxidation of promazine was inhibited only by quinine (K1=28.6 ćM), whereas that of perazine - by quinine (K1 = 10 ćM) and metyrapone (K1 = 96 ćM). The results obtained are compared with our previous findings of analogous experiments concerning thioridazine, and with the data on other phenothiazines and species. In summary, it is proposed that N-demethylation of the mentioned phenothiazine neuroleptics...


    1849/2523

    Tytuł oryginału: Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats.
    Autorzy: Przegaliński Edmund, Siwanowicz Joanna, Papla Iwona, Filip Małgorzata
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (5) s.387-396, il., bibliogr. s. 394-396
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study was designed to find out whether 5-HT1B receptors located in subareas of the nucleus accumbens played role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. Male Wistar rats implanted bilaterally with cannulae into the accumbens shell or core were microinjected with GR 55562 (an antagonist of 5-HT receptors) or cP 93129 (an agonist of 5-HT1B receptors). The rats, which were repeatedly (for 5 days) administered with cocaine (10 mg/kg) after 5-day withdrawal period, showed significantly higher locomotor hyperactivity in comparison with the observed in saline-pretreated and cocaine challenged rats. GR 55562 (0.1 - 10 ćg/side), administered for 5 days into the accumbens shell, but not into the core, prior to cocaine dose-dependently attenuated cocaine sensitization. When injected for 5 days into either the accumbens shell or core before cocaine, CP 93129 (0.1 - 10 ćg/side) had no effect on the development of cocaine sensitization. To examine the effects of GR 55562 and CP 93129 on the expression of cocaine sensitization, the drugs were given acutely before a challenge dose of cocaine (10 mg/kg) on day 10. No change in cocaine sensitization was observed after injection of GR 55562 (0.1 - 10 ćg/side) to the either accumbens subregion or after injection of CP93129 (0.1-10 ć/side) into the core. However, an intra-accumbens shell injection of CP 93129 (10-30 ćg/side) increased sensitization to cacaine, and this enhancement was attenuated after local injection of GR 55562 (1 ćg/side)...


    1850/2523
    - Copenhagen, , World Health Organization 2002
    Tytuł polski: National tuberculosis programme menagers' meeting : report on the fifth meeting
    Źródło: - Copenhagen, World Health Organization 2002, [4], 28 s. : il., tab., 30 cm. - 5 Spotkanie Menadżerów Narodowych Programów Zwalczania Gruźlicy Wolfheze 07-09.06. 2002
    Sygnatura GBL: 291,085

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny


    1851/2523

    Tytuł oryginału: Elevated plasma endothelin-1 concentration in non-dippers with essential hypertension.
    Tytuł polski: Podwyższone stężenie endoteliny 1 w osoczu u chorych z nadciśnieniem tętniczym bez spadku nocnego ciśnienia.
    Autorzy: Łapiński Mariusz, Januszewicz Andrzej, Symonides Bartosz, Lewandowski Jacek, Kuch-Wocial Agnieszka, Wocial Bożena, Ignatowska-Świtalska Hanna
    Źródło: Endokrynol. Pol. 2002: 53 (1) s.3-11, tab., bibliogr. 38 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy była ocena zależności między stężeniami w osoczu endoteliny 1 (ET-1) i przedsionkowego peptydu natriuretycznego (ANP) a dobowym rytmem ciśnienia tętniczego u chorych z nadciśnieniem tętniczym pierwotnym (EH). Materiał i metody: Do badań włączono 68 chorych z łagodnym do umiarkowanego EH. Grupę kontrolną stanowiło 25 zdrowych ochotników (C). Całodobowy pomiar ciśnienia tętniczego wykonano za pomocą aparatu SpaceLabs 90207. Stężenia ET-1 i ANP były oznaczane z próbek krwi pobranych w godzinach porannych. Wyniki: U chorych z EH stężenie osoczowe ET-1 było istotnie wyższe niż u C. Chorzy z EH zostali podzieleni na dwie grupy: chorych z zachowanym spadkiem ciśnienia tętniczego w nocy - tzw. dippers (n = 46; D) i chorych bez nocnego spadku ciśnienia tętniczego - tzw. non-dippers (n = 22.; ND). Stężenie osoczowe ET-1 było istotnie wyższe u ND niż u D (6,9 ń 0,7 i 4,5 ń 0,5 fmol/ml, p 0,05). Nie obserwowano różnic stężenia ANP w osoczu pomiędzy EH i C oraz pomiędzy D i ND. Stężenie ANP w osoczu u ND było wyższe niż u C (10,1 ń 1,5 i 6,4 ń 1; p 0,05). Wnioski: ET-1 i ANP mogą odgrywać rolę w zaburzeniach rytmu dobowego ciśnienia u chorych z nadciśnieniem tętniczym pierwotnym.

    Streszczenie angielskie: The aim of the study was to investigate the relationship between endothelin-1 (ET-10 and atrial natriuretic peptide (NP) plasma concentration and diurnal blood pressure rhythm in patients with essential hypertension. Material and methods: The study included 68 patients with mild-to-moderate essential hypertension (EH). The control group consisted of 25 healthy normotensive volunteers (C). Twenty-four hour ambulatory blood pressure monitoring was obtained, using SpaceLabs 90207. Blood samples for ET-1 and ANP were collected. Results: In patients with EH ET-1 plasma concentration was sinificantly higher as compared with C. Patients with EH were divided into two groups: dippers (46 pts; D) and non-dippers (22 pts; ND). In EH, the ET-1 plasma concentration was significantly higher in non-dippers than that in dippers (6.9 ń 0.7 vs 4.5 ń 0.5 fmol/ml, p 0.05). No differences in plasma ANP concentration were observed EH and C and between D and ND. Plasma concentration of ANP in ND was higher than that in C (10.1 ń 1.5 vs. 6.4 ń 1.0 fmol/ml; p 0.05). Conclusion: ET-1 and ANP may play some role in the lack of nocturnal blood pressure fall in non-dippers with EH.


    1852/2523

    Tytuł oryginału: Disorders of thyroid function and hormone release from the rat pituitary.
    Tytuł polski: Zaburzenia czynności gruczołu tarczowego a uwalnianie hormonów z przysadki szczura.
    Autorzy: Stempniak Bożena, Marczyński Andrzej, Dąbrowski Ryszard
    Źródło: Endokrynol. Pol. 2002: 53 (1) s.13-22, il., bibliogr. 28 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Celem doświadczeń było zbadanie, czy niedoczynność gruczołu tarczowego (po tyreoidektomii lub zastosowaniu metylotiouracylu) lub nadmiar w osoczu L-tyroksyny (L-T4) zmieniają uwalnianie do krwi tyreotropiny (TSH), prolaktyny (Prl), wazopresyny (VP) i oksytocyny (OT) u szczurów szczepu Wistar. Stężenie wolnej trijodotyroniny (FT3), wolnej tyroksyny (FT4), TSH, Prl, VP i OT w osoczu krwi oznaczano metodami radioimmunologicznymi. Wycięcie gruczołu tarczowego spowodowało obniżenie stężenia FT3, FT4, VP i OT oraz znaczne zwiększenie stężenia TSH i Prl w osoczu krwi; podobne wyniki uzyskano w grupie zwierząt otrzymujących 0.1 proc. roztwór metylotiouracylu. Wstrzykiwanie zwierzątom L-T4 nie zmieniło w sposób istotny stężenia Ft4 i FT3 oraz OT w osoczu krwi, obniżyło zaś stężenie TSH oraz wyraźnie podwyższyło stężenie VP i Prl w osoczu krwi. Z doświadczeń obecnej pracy wynika, iż zaburzenia czynności hormonalnej gruczołu tarczowego modyfikuje uwalnianie hormonów zarówno płata tylnego, jak i przedniego przysadki.

    Streszczenie angielskie: The effects of hypothyroidism caused by thyroidectomy or by adding 0.1 p.c. 4-methyl-2-thiouracil (MTU) solution to drinking water for 2 weeks, and the effect of hyperthyroidism, induced by the administration of L-thyroxine (L-T4), on the concentration of thyroid stimulating hormone (TSH), prolactin (Prl), vasopressin (VP) and oxytocin (OT) in blood plasma, were studied in Wistar rats. Levels of free triiodothyronine (FT3), free thyroxine (FT4), TSH, and Prl were estimated by specific RIAs in unextraced plasma. Vasopressin and oxytocin were extracted from plasma, using C18 Sep-Pak columns and determined by doubleantinody specific RIA. The results show that plasma concentrations of TSH and Prl are increased, whereas plasma levels of FT3, FT4, VP and OT are decreased in rats with hypothyroidism. The data from the present study indicate that L-T4 treatment for the induction of hyperthyroidism does not results in elevated plasma levels of FT3 and FT4. L-thyroxine administration decreased TSH and increased VP and Prl levels in plasma but did not change OT concentration. These results suggest that thyroid hormones may play a regulatory role, both in the posterior and in anterior pituitary function.


    1853/2523

    Tytuł oryginału: Effect of dexametasone in the content of ceramide and sphingomyelin in rat skeletal muscles.
    Tytuł polski: Wpływ deksametazonu na zawartość ceramidu i sfingomieliny w mięśniach szkieletowych szczura.
    Autorzy: Żendzian-Piotrowska Małgorzata, Górska Maria, Dobrzyń Agnieszka, Zabielski Piotr
    Źródło: Endokrynol. Pol. 2002: 53 (1) s.39-49, tab., bibliogr. 28 poz.
    Sygnatura GBL: 304,167

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Ceramid jest wtórnym przekaźnikiem sfingomielinowego szlaku przezbłonowej transmisji sygnałów. Wykazano, że deksametazon zwiększa zawartość ceramidu w komórkach linii WEHI 231. Celem obecnej pracy jest zbadanie wpływu dekametazonu na zawartość i skład ceramidów i sfingomielin w mięśniach szkieletiowych in vivo. Deksametazon (Sigma) podawano szczurom podskórnie w dawce 5 mg/kg codziennie przez 7 dni. Szczury usypiano i pobierano następujące mięśnie: płaszczkowaty, "czerwoną" oraz "białą" część mięśnia dwugłowego łydki. Mięśnie te składają się, odpowiednio, głównie z następujących typów włókien: wolno-kurczące się tlenowe, szybko-kurczące się tlenowo-glikolityczne oraz szybko-kurczące się glikolityczne. Lipidy ekstrahowano za pomocą mieszaniny chloroformu i metanolu (2:1). Ceramid i sfingomielinę izolowano za pomocą chromatografii cienkowarstwowej. Kwasy tłuszczowe obu tych związków identyfikowano i oznaczano ich zawartość przy pomocy chromatografii gazowo-cieczowej. Zidentyfikowano 12 ceramidów i 12 sfingomielin w każdym z mięśni. Zawierały one reszty następujących kwasów: mirystynowego, palmitynowego, palmitooleinowego, stearynowego, oleinowego, linolowego, linolenowego, arachidonowego, eikozapentaenowego, behenowego, dokozaheksaenowego i nerwonowego. Deksametazon zwiększył zawartość ceramidu w każdym z mięśni. Równocześnie, w obu częściach mięśnia dwugłowego łydki, zwiększył odsetek ceramidów zawierających nasycone kwasy tłuszczowe. Deksametazon obniżył zawartość ...

    Streszczenie angielskie: Ceramide is the second messenger in the sphingomyelin transmembrane signalling pathway. Studies on WEHI 231 cells indicate that dexametasone increases the production of ceramide. The aim of the present study was to examine the effect of dexametasone on the content and composition of ceramides and sphingomyelins in rat skeletal muscle in vivo. The hormone was administered subcutaneously, daily, for 7 days, in a dose of 5 mg/kg. The following muscles were taken: soleus, red and white section of the gastrocnemius. The muscles are composed predominantly of the slow-twitch oxidative, fast-twitch oxidative-glycolytic and fast-twitch glycolytic fibers, respectively. Lipids were extracted with chloroform/methanol (2:1). Ceramide and sphingomyelin were separated by means of thin-layer chromatography. Their fatty acids were identified and quantified by means of gas-liquid chromatography. Twelve different ceramides and sphingomyelins were identified in each muscle. They contained the following acid residues: myrystic, palmitic, palmitoleic, stearic, oleic, linoleic, linolenic, arachidonic, eicosapentaenoic, behenic, docosaheksaenoic and nervonic. Treatment with dexametasone resulted in an elevation of the total content of ceramide-fatty acids and increased the percentage of saturated fatty acids in each muscle. The hormone reduced the total content of sphingomyelin-fatty acids and did not affect the composition of the acids in the muscles. The elevation in the content of ...


    1854/2523

    Tytuł oryginału: Cancer imaging with radiolabelled antibodies and peptides.
    Autorzy: Britton Keith E., Granowska Marie
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.89-92, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • urologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1855/2523

    Tytuł oryginału: Comparison of 99mTC-alafosfalin and 67Ga-citrate in a mouse model of bacterial infection.
    Autorzy: Tsopelas Chris, Penglis Stan, Bartholomeusz F. Dylan L.
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.93-97, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: Background: The antibiotic-peptide 99mTC-alafosfalin was assessed as an infection imaging agent in Staphylococcus aureas infected mice by comparison with 99mGa-citrate, and also examined for influence of septic status on tracer biodistribution by comparison with normal mice. Material and methods: Intramuscular doses of S. aureus were administered into the right thigh muscle of mice and the infection was allowed to develop for 20 hours. In separate experiments, 99mTC-alafosfalin and 67Ga-citrate were subsequently administered adn allowed to localise. Quantitative organ distribution sstudies were performed in conjunction with scintigrapic images at 1 and 4 hours posst injection. An additional biodistribution with 99mTC-alafosfalin in normal mice was also performed. Results: 99mTC-alafosfalin was predominantly renal excreted, with low liver, intestine and bone uptake. Tehre was no difference in the uptake of these organs when infected mice were compared with normal mice. 99mTC-alafosfalin activity in the intestine at 1 and 4 hours was substantially less than 67Ga-citrate. For 99mTC-alafosfalin, infected/non-infected thigh ratios of 2.8/1.0 and 3.6/1.0 were determined at 1 and 4 hours post injection resepectively. 67Ga-citrate gave ratios of 1.6/11.0 and 3.7/1.0 at teh corresponding time points. Conclusions: 99mTC-alafosfalin uptake was mnore rapid than 67Ga-citrate, yet diffuse at the infectious sites in mice. The small and juvenile mouse model resulted in uptake of the phosphonic acid tracer by active ...


    1856/2523

    Tytuł oryginału: Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy: preparation , size determination, in-vivo distribution, effects and dosimetry studies.
    Autorzy: Math‚ Domokos, Chaudhari Pradip R., Balogh Lajos, Polyak Andras, Kiraly R‚ka, Andócs Gabor, Perge Edina, Glavits Róbert, Janoki Gyozo A.
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.99-104, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia
  • chirurgia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • płeć męska

    Streszczenie angielskie: Background: Generator-produced beta-emitting radionuclides such as 188Re are gaining in importance for radiossynoviorthesis because of their availability on a regular basis. Material and methods: We prepared a 188Re-tin colloid in a eraction carried out either at 100 řC or at room tempereature (RT). The size of the colloid particles was measured wwith a laser lightscattering method, and their biodistribution, dosimetric apsects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed.Blood sapmles were collected post injection for estimation ofthe blood residence time. We aslo injected 2 intact rabbits in the same manner with 188Re perrhentage solution in order to observe its effects and distribution in teh body. All the treated rabbit knees were subjected to histopathology. Results: The colloid particle size distribution was different after preparation at teh different reaction temperatures, with a more suitable mean of 4.53 ćm in the RT preparation. The dose delivered to the synovial ssurface was between 33.51 and 4.21 Gy and that to the bone surface was betwen 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the knees 4 weeks after treatment, but not in the control group. Conclusions: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. ...


    1857/2523

    Tytuł oryginału: Optimal time window for measurement of renal output parameters.
    Autorzy: Kuyvenhoven Jacob D., Ham Hamphrey R., Piepsz Amy
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.105-108, il., bibliogr. 8 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Although normalised residual activity (NORA) and output efficiency (OE) are usually measured at a fixed time, their dependency on t may affect the prediction of mean transit time (MTT). This study aimed to evaluate their degree of dependency on t and to determine an optimal time of measurement by assessment of their relationship with NTT for various times. A simulation model generated 232 cortical renograms by convolving one plasma disappearance curve with 232 created cortical retention functions. The results show that considerable changes are observed for NORA and OE, depending on the time of measurement t. The choice of this time significantly influences the predictive value ofthese parameters for estimating MTT. The optimal time for measurement of NORA and OE should be close to the MTT , at the moment when emptying takes place. In the clinical practice. It should be adapted to the clinical problem under investigation.


    1858/2523

    Tytuł oryginału: Estimation of usefulness of monitoring tissue polypeptide antigen - TPA-M concentrations in the effectiveness of surgical treatment of urinary bladder cancer.
    Autorzy: Kochańska-Dziurowicz Aleksandra A., Mielniczuk Michał J., Bijak Aleksandra, Palugniok Ryszard
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.109-111, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: Of all cancer tumours, urinary bladder cancer is the fourth must common in men and the seventh in women. The aim ofthis work was to answer the queation whether tissue polypeptide antogen (TPA-M) determination in patients afetr electroresection of urinary bladder cancer can be used to estabilish the probability of tumour recurrence. Material and methods: The research included 98 patients, all of wwhom had undertaken electroresection of urinary bladder tumour (TURT), wwhich enabled its removal, and then estimation of malignancy and progression stage according to the international TNM scale. The mean age was 62.7 years. All patients had blood samples taken to determine TPA-M and then underwent routine cystoscopy examination. Results: The patients with tumour recurrence (60, mean age 64 ń 10) had TPA 30.2 ń 4.3 U/l, the patients without recurence (38, mean age 61.3 ń 11) had TPA-M 26.2 ń 3.118 U/l (p 0.1). Taking the TPA-M threshold point 85 U/l as normal, true-positive results were 16.3 p.c., true-negative were 31.6 p.c., false-positive results were 7.1 p.c. false-negative were 44.9 p.c. The ROC curves with the calculated area under them are the measurement of the diagnostic estimation of TPA-M concentrations in specificity and sensitivity categories. Conclusions: For the examined group the calculated P was 0.45. If P value is under 0.5 it is considered that the test should not be used in diagnosing reccurrence of urinary bladder cancer.


    1859/2523

    Tytuł oryginału: Early and late changes in myocardial function and heart rate variability in patients after myocardial revascularisation.
    Autorzy: Szot Wojciech M., Bacior Bogumiła, Hubalewska-Hola Alicja, Grodecki Janusz, Szybiński Zbigniew, Kawecka-Jaszcz Kalina
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.113-119, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of the study was to evaluate the effect of myocardial revascularisation and associated improvement of left ventricular systolic function on heart rate varibaility in patients afetr myocardial infarction. Material and methods: The study population consisted of 35 patients, who within the previous 6 months had suffered from myocardial infarction and in whom low dose dobutamine ventriculography revealed hibernating myocardium, whereas coronaryy angiography provided indications to revascularisation. CABG was perforemd in 22 patients, PTCA of the infarct-related artery in 13 patients. At baseline, 3 months and 3 years after the procedure radionuclide ventriculography, myocardial perfusion scintigraphy and 24hr continous ECFG recording were performed. Results: After initial improvement of systolic function in ventriculography (EF = 48.63 ń 11.6 v. 52.37 ń 11.27 at p 0.001) it slightly but not significantly decreased at long-term follow-up (EF = 51.8 ń 10.77). The remaining parameteres of systolic function behaved in a ssimilar way in radionuclide ventriculography. Diastolic function parameters did not change significantly at early and long-term follo-up. HRV measures did not change at 3 months but at 3 years both sympatehtic- and parasympathetic-related parameters and global autonomic acctivity very diminished. At 3 years global autonomic activity and parasympaatehtic activity were diminished with their values similar in both groups. Conclusions: It seems that HRV measures diminish at ...


    1860/2523

    Tytuł oryginału: 111 In-platelest dynamic study in chronic immune thrombocytopenic purpura.
    Autorzy: Todorović-Tirnanić Mila V., Obradović Vladimir B., Pavlović Smiljana V., Suvajdzić Nada D., Elezović Ivo V., Colović Milica D., Bosnjaković Vladimir B.
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.121-125, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • pediatria
  • radiologia
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of this work was to estimate the significance of a dynamic study performed during the first 20 minutes afetr autologous 111In-oxinate-platelets injection in patients with chronic immune thrombocytopenic purpura (ITP). Two hypotehses were tested: a) dynamic study indicates the place of platelet sequestration; b) dynamic study reflects the quality of platelet separation and labelling procedure. Material and methods: Thirty-nine persons were investigated: 25 with shortened platelet life span (ITP) and 14 with noraml platelet life span (6 healthy subjects and eight patients with myelodysplastic syndrome - MDS). Platelet blood count on the day of platelet labelling, general yield of platelet labelling (GYL), differential yield of platelet labelling (DYL), platelet life span, dynamic study with initial platelet accumulation in the liver (IPAL), sequential static study for determining the platelet sequestration index (SI) and platelet sequestartion site (SS) were investigated. Results: Two types of labelled platelet kinetics were determined in both groups of patients : OPAL 20 p.c. and IPAL 20 p.c. A statistically significant difefrence in GYL and DYL was noted between the patients with IPAL 20 p.c. and IPAL 20 p.c. No significant difefrence was registered in platelet blood count, life span, SS and SI bewteen the two groups of patients. Both yields of platelet labelling were higher in the group with IPAL 20 p.c. There was no correlation bewteen IPAL and platelest SI, or between ...


    1861/2523

    Tytuł oryginału: The diagnostics of recurrent gliomas using FDG-PET: still questionable?
    Autorzy: Belohlavek Otakar, Klener Jan, Vymazal Josef, Dbaly Vladimir, Tovarys Frantisek
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.127-130, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • radiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: For a number of years, FDG-PET was considered as a gold standard for the differential diagnosis of recurrent glioma and radionecrosis. Recently published papers haave introduced a waealth of scepticism into this area. The aim of this work is to specify the added value of FDG PET, as compared to MRI, in terms of diagnostics of recurrent gliomas in the clinical setting of the PET Centre Prague. Material and methods: MRI and FDG-PET were used to exmaine 29 patients for suspicious glioma recurrence, after 30 open neurosurgical operations or re-operations combined with chemo- and/or radiotherapy. The sensitivity, specificity and accuracy of both examinations were calculated with respect to their micromorphological findings (n = 28) or the clinical and radiological follow-up (n = 2). Results: MRI detected 23/24 tumour recurrences (sensitivity = 95.8 p.c.) and FDG PET only 15 of these (sensitivity = 62.5 p.c.) MRI specified only 3/6 radionecrotic lesions (specificity = 50.0 p.c.), while FDG PET identified 5/6 (specificity = 83.3 p.c.). Overall accuracy was 26/30 (86.7 p.c.) for MRI and 20/30 (66.7 p.c. ) for FDG PET. In the subgroup of MRI positive or equivocal findings (n = 229) FDG PET was clearly positive in 15 cases. High-grade glioma recurrence was subsequently confirmed in all of them. On the other hand negative or equivocal FDG PET was associated in 5/14 cases (35.7 p.c.) with radionecrosis, in 333/14 (21.4 p.c.) with low-grade glioma and in 6/14 (42.9 p.c.) with high-grade glioma. Conclusions: ...


    1862/2523

    Tytuł oryginału: Technetium-99m MIBI imaging in diagnosis of pelvic and abdominal masses in patients with suspected gynaecological malignancy.
    Autorzy: Królicki Leszek, Ćwikła Jarosław B., Timorek Agnieszka, Ruszczyńska Małgorzata, Stelmachow Jerzy, Sawicki Włodzimierz, Kolasińska Agnieszka D., Kupryjańczyk Jolanta, Lieberman Gidon, Buscombe John R.
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.131-137, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • pediatria
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of this study was to determine the diagnostic value of 99mTcMIBI planar dynamic scintigraphy in the diagnosis of gynaecological malignancies and to determine if it has a greater diagnostic accuracy than conventional ultrasound technique (US). Material and methods; A prospective trial was performed to assess the accuracy of 99mTcMIBI scintigraphy and ultrasound in 93 female patients (mean age 50, SD 16; range 17-82 years). Three readers assessed all the imaging independently and this was comparedd with histological eamination in 89 cases and by clinical follow-up and correlative imaging for a minimum of 6 months in 4 patientss. Results: There were 37 patients with cancer of gynaecological origin. Tehre were in addition 56 benign lesions within the pelvis. 99mTcMIBI identified correctly 29 of the 337 malignant tumours localised within the pelvis and also correctly identified 21 of 23 metastases within the abdomen. Conventional US identified correctly 35 of the 37 tumours in the pelvis and 16 sites of metastsaes within the abdomen. The sensitivity and specificity of tumour detection within the pelvis for 99mTcMIBI were as follows: 78 p.c. and 70 p.c.; and for metastases within the abdomen 91 p.c. and 90 p.c. The results of ultrasound for tumour detection within the pelvis: the sensitivity and specificity were 95 p.c. and 79 p.c. and abdominal metastases 70 p.c. and 97 p.c. Analysis of the index area under a receiver operator characteristic (ROC) curve in scintigraphy did not show a ...


    1863/2523

    Tytuł oryginału: Preliminary radiochemical and biological studies on the liposome encapsulated platinum-[125I]iodohistamine complex.
    Autorzy: Garnuszek Piotr, Licińska Iwona
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.145-149, il., bibliogr. 18 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: Background: The platinum-iodohistamine complex with in vitro cytostatic activity toward colon and mammary cancer cells has been synthesised recently in our laboratory. The pharmacokinetics of radioactive complex analogues, labelled with I-131 and I-125, has been examined in murine model of spontaneous mammary adenocarcinoma. The present work is devoted to the examination of the potential use of liposomes as a carrier system for the radioactive platinum-[I]iodohistamine complex in vivo. Material and methods: Encapsulations of the Pt-[125I]iodohistamine were studied using a different molar ratio of the com[lex and liposome with positive surface charge, as well as various incubation procedures. Biodistribution of the initial and the liposomal from of the complex were studied in C3H tumour-bearing mice with spontaneously developed and transplantable (16C) mammary adenocarcinoma. results: Comparative biodistribution studies in C3H/16C mice and in mice with spontaneously developed mammary tumour have shown that in the former model pharmacokinetics of the Pt-[125I]iodohistamine complex is more predictable and more similar to that observed for cisplatin. Therefore, the transplantable tumour model is more advantageous for the complex and its liposomal from evaluation. In C3H/16C mice, signifiant differences in the biodistribution between the raadioactive platinum complex and its liposomal form were observed. The concentration of the activity in blood after 2 h p.i.v. was two times lower for the encapsulated ...


    1864/2523

    Tytuł oryginału: Detection of acute gastrointestinal bleeding by means of techentium-99m in vivo labelled red blood cells.
    Autorzy: Doleżal Jiri, Vizd'a Jaroslav, Bures Jan
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.151-154, il., bibliogr. 10 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • radiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Prognosis of gastrointestinal (GI) bleeding depends on the timely [3] and accurate [8, 18] detection of the source of bleeding and sequential surgical or endoscopy therapy. Scintigraphy with red blood cells (RBCs) in vivo labelled by means of technetium-99m hastened detection of source of GI bleeding and improved management of the particular disease. Gastrointestinal endoscopy is the method of choice for the diagnostics of bleeding from upper tract and large bowel. For diagnostics of bleeding from the small bowel we can use scintigraphy with in vivo labelled autological red blood cells if push-enteroscopy, intra-operative enteroscopy or angiography are not available. Material and methods: 31 patients (13 men, 18 women, aged 20-91, mean 56 years) underwent this investigation from 1998 till 2001 at the Department of Nuclear Medicine. ALl patients had melanea or enterorrhagia associated with acute ananmia. Gastroscopy, colonoscopy, enteroclysis or X-ray angiography did not detect the source of bleeding. Results: Twenty-one patinets had positive scintigraphy with in vivo labelled RBCs - 9 patients were already positive on dynmaic sscintigraphy, and 12 patients were positive on static images. Scintigraphy with in vivo labelled RBCs was negative in 10 patients. Gl bleeding stopped spontaneously in these 10 patients with negative scintigraphy. These patients did not undergo intra-operative enteroscopy or surgery. The final diagnosis of the 21 patients with positive scintigraphy was determined in 16 patients ...


    1865/2523

    Tytuł oryginału: Effect of biventricular pacing on heart function evaluated by gated blood pool study in patients with end-stage heart failure.
    Autorzy: Cholewiński Witold, Tarkowska Anna, Kutarski Andrzej, Stefaniak Bogusław, Poniatowicz-Frasunek Ewa, Oleszczak Krzysztof
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.155-157, il., bibliogr. 5 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Biventricular cardiac paacing has been used as a complementary from of therapy in patients with severe heart failure. The aim of this study was to evaluate the effect of the synchronous stimulation of both ventricles on the heart function measuremed by gated blood pool study (GBP). Material and methods: Ten patients (9 men and 1 woman aged 53-74 years) with end-stage heart failure (HF) were studied. In all patients lon-term biventricular pacing (BV) was applied. The obtained results were compared with single-chamber stimulation in 5 patients and with sinus rhythm (SR) in 8 patients. All patients underwent repeated GBP with RBC labelled with 740 MBq of 99 mTc-pertechnetate. The LVEF was calculated according to the standard method based on the count rates. Phase analysis was performed with the standard method using first Fourier element. Results: Clinically in almosst all patients moderate to important symptomatic improvement has been observed. The analysis of LVEF values revealed that BV pacing resulted in significantly higher values only in comparison with SR (21.6 p.c. ń 10.3 v. 20.1 p.c. ń 10.1 ; p 0.05). The phase sshift between both ventricles by BV pacing was positive and similar to that obtained with SR and RV stimulation (14.0ř ń 29.6 v. 13.4ř ń 37.6 and 7.4ř ń 26.5 v. 6.0ř ń 17.1 respectively). However, incomparison with LV pacing, BV stimulation revealed a change of dominant connduction abnormalities with a delay of RV contraction in relation to LV (9.0ř ń 17.5 v. -3..0ř ń 11.4)...


    1866/2523

    Tytuł oryginału: Comparison of peritumoral and subareolar injection of Tc99m sulphur colloid and blue-dye for detection of the sentinel lymph node in breast cancer.
    Autorzy: Jastrzębski Tomasz, Kopacz Andrzej, Lass Piotr
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.159-161, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The new trend in diagnosis of the lymph node is sentinel node biopsy. This method has become increasingly accepted as a minimally invasive alternative to routine axillary dissection. Although the results of numerous studies have shown that sentinel node biopsy can accurately determine the axillary nodal ststus, the identification rates and false-negative rates haave been variable. The sentinel lymph node is defined as the first node in the lymphatic basin that receives the primary lymphatic flow. Material and methods: Between September 1998 and August 2002 123 patients with primary operative breast cancer without clinical palpable axillary lymph nodes were enrolled in the study. There were two groups of patients according to sentinel node identificction technique: 51 patients (Group I) received parenchymal, peritumoral injection of 1.0 ml of 16 MBq Tc99m -radiolabelled sulphur colloid and single intradermal injection of blue-dye over the tumour. The next 72 patients (Group II) received intradermal, periareolar one-site injection of 0.5 ml of 16 MBq Tc99m-radiolabelled sulphur colloid and blue-dye. Results: Sentinel lymph node was found in 41 (80.4 p.c.) cases in Group I and in 67 (93.0 p.c.) cases in Group II (p = 0.028). The localisation of the axillary lymph node as a "hot spot" visualised by lymphoscintigraphy was successful in 39/51 (76.5 p.c.) cases in Group I and 67/72 (93.0 p.c.) Group II, p = 0.004). In both groups the success of sentinel node identification in the axillary region ...


    1867/2523

    Tytuł oryginału: Windows programming - Maximum Intensity Projections with direct export to avi.
    Autorzy: Masopust Jan, Janeba Daniel, Taborska Katerina
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.163-164, il., bibliogr. 3 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1868/2523

    Tytuł oryginału: Evaluation of nuclear medicine tests for the diagnosis of breast carcinoma.
    Autorzy: Grammaticos Philip C.
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.165-170, il., bibliogr. 44 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: In this paper, we evaluate nuclear medicine tests used for the diagnosis of breast carcinoma. Breast carcinoma is the most common carcinoma in women in Europe and its early diagnosis and treatment is important for the overall survival of the patients. Scintimammography technique, indications, contraindications and diagnostic procedures for the identification of the sentinel node and the axillary nodes infiltrated by tumour are described. Also, the use of the radiopaheramceuticals, radioactive thallium chloride-201, methylene diphosphonate labelled with technetium-99m, somatosatin receptors labelled with indium-111, diagnosticc procedures with the PET camera, the labelled antibodies to CEA with technetium-99m and also the importance of the MRI and the US techniques are mentioned. These tests have diagnosstic accuracy as compared to X-ray mammography, clinical examination, MRI and the US technique. Tumour markers in vitro are recommended for the follow-up of metastatic breast carcinoma.


    1869/2523

    Tytuł oryginału: The role of sentinel node detection techniques in vulvar and cervical cancer.
    Autorzy: Wydra Dariusz, Sawicki Sambor, Emerich Janusz, Romanowicz Grzegorz
    Źródło: Nucl. Med. Rev. 2002: 5 (2) s.171-174, bibliogr. 24 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: The sentinel node is the first lymph node that receives the lymph drainage from the primary tumour. The pathological ststus of the sentinel node should reflect the histopathology of the entire regional lymph drainage area - both vulvar and cervical cancer spread through the lymphatic system. In gynaecological oncology recent studies have confirmed the utility of the sentinel node concept in vulvar and cervical cancer. Three techniques for sentinel node localisation are available. The preoperative lymphoscintigraphy and intraoperative handheld gamma probe detection require the administration of the technetium-99m-labelled colloid around the tumour. The other method is based on the injection of the patent blue dye - during the surgery of the sentinel node because of the dye uptake becomes visible. Following detection, the sentinel lymph node can be removed separately and assessed with ultrastaging and immunohistochemical staining. In the early stages of vulvar and cervical cancer the lymph nodes metastases rate is relatively low - in most cases lymphadenectomy is not necessary. The determination of the regional lymph nodes pathological status may limit the extent of the surgical treatment. The sentinel node detection rate is relatively high and depends on the applied technique. This technique may paly an important role in the treatment of vulvar and cervical cancer. This paper describes the details of sentinel node identification and reviews the literature.


    1870/2523

    Tytuł oryginału: The ABCs of cognition, emotion, and action.
    Autorzy: Wirga Mariusz, Bernardi Michael de
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.5-16, il., bibliogr. 52 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: It has been over 35 years since Albert Ellis first formulated his ABC model of human disturbance, and 70 years since Woodworth described the SOR (Stimulus - Organismic response - emotional and behavioural Response) mechanism of human behaviour, an early ancestor of Ellis' theory. While the ABC model has made a great impact on the development and current popularity of cognitive-behaviour therapy, it has also been at the centre of significant controversy in cognitive neuroscience over the past three decades. In this article, we address the main controversies from our somewhat radical perspective, and provide a simple that we utilise clinically with our patients to help them gain a quick and meaningful insight into this ABC model of their own emotions. We support our position with a brief overview of the neuropsychological mechanisms involved in emotional reactions and the psychoneuroimmunological implications of the perspective. Finally, we will present the basic rules for healthy thinking as put forth by Maultsby and modified by Simonton, and discuss their clinical role in the treatment of patients with life threatening diseases and challenges concerning spiritual/religious/philosophical/existential issues.


    1871/2523

    Tytuł oryginału: The prevalence of dementia in Poland: a population-based, door-to-door survey in an urban community.
    Autorzy: Gabryelewicz Tomasz, Parnowski Tadeusz, Szafrańska Anita, Matuszewska Elżbieta, Jarkiewicz Elżbieta, Kotapka-Minc Sławomira, Baro Franz
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.17-26, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The community survey of the Warsaw district Mokotów estimated the prevalence of dementia in a random, population-based sample, stratified for age and sex. The sample of 1000 elderly (65-84 years) was screened at home with the MMSE test. All elderly under the cut-off 24-25/30 was assigned a diagnosis via the CAMDEX and the DSM-IIIR. The prevalence of dementia was estimated at 5.7 p.c. The following age-specific prevalence of dementia was found in the age groups 65-69, 70-74, 75-79, 80-84: 1.9, 5.8, 8.6 and 16.5 p.c. Rates for VD - 2.7 were higher then those for DAT - 2.3, mixed dementia- 0.5, and secondary dementia - 0.2 p.c. In the younger subgroups (65-74 years) VD was the most frequent and in the older subgroups (75-84 years) the most frequent was DAT. The rates of dementia were quite similar to those found in other European studies.


    1872/2523

    Tytuł oryginału: The predictive value of MMSE, ADAS-cog, IADL and PSMS as instruments for the diagnosis of pre-clinical phase of dementia of Alzheimer type.
    Autorzy: Bidzan Leszek, Bidzan Mariola
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.27-33, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the present study was to describe factors that allow for the estimation of the degree of risk in the development of dementia (Alzheimer type). A five-year observation was performed on 204 indyviduals. Among the examined population, during the five-year observation, Alzheimer type dementia was recognised in 19 individuals. Based on the examination conducted after five years, the examined population was eventually divided into two groups: without dementia syndrome (Control group, n=185) and individuals in which Alzheimer type dementia was recognised during the five-year observation period (DAT group, n=19). A statistic analysis of the results indicates that it is possible, on the basis of the examination by means of proper clinical scales, to predict the danger of dementia, however it is necessary to take into account various elements of psychic state and social functioning. This is discussed in detail.


    1873/2523

    Tytuł oryginału: Willingness to communicate and self-presentation as chosen aspects of social activity in depressive patients.
    Autorzy: Nowicka-Sauer Katarzyna
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.35-42, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Willingness to commmunicate and self-presentation in depressive patients and healthy individuals were compared. Significant differences were found.


    1874/2523

    Tytuł oryginału: Psychosocial correlates of suicidal behaviour in alcohol dependent persons. A pilot study.
    Autorzy: Brodniak Włodzimierz Adam, Wójtowicz Stanisław
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.43-51, tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Suicidality among alcohol dependents isa crucial problem as viewed from the diagnostic, therapeutic, and especially preventive perspectives. The aim of the study was to find which of the selected psychosocial variables were correlates of suicidal behaviours in alcohol dependent people. There groups of 30 subjects each were compared: a) alcoholics who attempted suicide in the past 4 years, b) alcohol dependent people without previous suicidal attempts, and c) persons with no dependence or suicidal attempts. The two control groups (b and c) were pair matched for sex, age and education. All alcohol dependent subjects were patients of there outpatient clinics or an alcohol inpatient ward in Warsaw. There instruments were used: a sociological SSS questionnaire (measuring the social suppport system), Beck's Depression Inventory, and the Orientation of Life Questionnaire SOC-29 developed by Antonovsky to measure the sense of coherennce (SOC). Eleven hypotheses were verified in thestudy. Results of statistical analyses indicate the following 7 variables as correlates of suicidal behaviours: 1. more marked depressive symptoms, 2. weaker SOC, 3. longer history of alcohol abuse and more hospitalisations for alcohol problems, 4. unemployment or low status in the workplace, 5. more limited and weaker system of social support (quantitatively and qualitatively), 6. more negative life events, 7. more family problems (divorce, separation) and loneliness, Generalisation of these findings and their implementation in diagnostic, therapeutic and preventive terms would require replication of the study on large, representative random samples.


    1875/2523

    Tytuł oryginału: Psychometric profiles in Italian Hare Krishna Movement. Affiliation and membership.
    Autorzy: Di Fiorino Mario, Fizzotti Eugenio, Miniati Marina
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.53-61, tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The authors have tested 70 Italian Hare Krishna in the temples of Florence and Albettone (Vicenza) on the MMPI and on the Autoevaluation Questionnaire on Hare Krishna Movement Belinging. According with the findings described by Ross [1], our study does not reveal evidence of any important mental disorder, although members of the long-term group (after 3 years) in the movement, particularly men, have shown lowerbmean scores at Pd (psychopathic deviate) scale than members of the short-term one (less than 3 years). Moreover, examining individually the profiles, it seems that a lasting stay in the group affects as a protective factor, some psychological aspects, even if alternative explanations are discussed. However this protective factor has a poor significance on personalities which present more serious indications of psychopathology.


    1876/2523

    Tytuł oryginału: Long-term group psychotherapy of schizophrenia in the private practice setting: description of two year's experience.
    Autorzy: Kokoszka Andrzej
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (1) s.63-78, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Analysis of literature indicated that tong-term outpatient supportive psychotherapy of schizophrenia in the private practice setting is a neglected topic. The general rules of psychotherapy of schizophrenia are briefly summmarised. The theoretical presumptions of the developed metod of 90-minute, monthly sessions, psychodynamic, supportive slow-open, long-term psychotherapy for 6-8 patients, conducted in the private practice setting are described. Analysis of the results after the first and the second year of therapy indicates that an elaborated method may be useful and valuable. However, further observations and studies are needed.


    1877/2523

    Tytuł oryginału: Monte Carlo calculations of dose distribution for 32P brachytherapy wire source.
    Autorzy: Wincel Krzysztof, Zaręba Barbara
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (2) s.63-69, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The MCNP Monte Carlo transport code [1] with the MCNPDATA cross section library [2] has been used to calculate absorbed dose distribution in water and polymethylmethacrylate (PMMA) for a 32P Guidant Corporation source. The paper presents the calculated absorbed doserate radial distribution for water and PMMA and absorbed dose rate axial distribution for water. Based on the calculated radial absorbed dose distributions, the scaling factor of the PMMA relative to water was determined. The sensitivity of the calculated absorbed doses to source electron energy spectrum was investigated. Calculations were performed using a personal computer with a Pentium III 600 MHz processor.


    1878/2523

    Tytuł oryginału: Monitor unit calculation in radiotherapy performed with large fields at large distances.
    Autorzy: Maniakowski Zbigniew, Orlef Andrzej
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (2) s.81-88, il., tab., bibliogr. 5 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In half-body (HBI) and total-body (TBI) irradiation techniques large fields and large source-to-skin distances (SSD) are required. The method of Tissue Phantom Ratio (TPR) measured at the isocentre can then used for calculating the dose and the required number of monitor units. However, at source-to-skin distances well exceeding 100 cm, modification of the algorithm and suitable extrapolation of data are required. We propose a modification of the TPR-based algorithm which can lead to reliable dose calculations for the HBI and TBI techniques. The extension of the TPR algorithm is based on the well-known principle of separating the total scatter factor, Scp, into collimator-scatter, Sc, and phantom-scatter, Sp, components. The algorithm proposed by us was experimentally verified for several field sizes and over a wide range of distances. At reference depth the difference between the measureds at the calculated dose values does not exceed 1 p.c.


    1879/2523

    Tytuł oryginału: Digital analysis of ophthalmological images - a proposal for a screening strategy.
    Autorzy: Berndt-Schreiber Maria, Bieganowski Lech, Kowalczyk Andrzej, Maciejewski Krzysztof
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (2) s.89-98, il., bibliogr. 10 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The purpose of our study ias to develop a cost-effective and objective method supporting ophthalmologist diagnosis in mass examinations. Fundus eye images are acquired in routine ophthalmologist diagnosis in mass examinations. Fundus eye images are acquired in routine ophthalmologist diagnosis in mass examinations. Fundus eye images are acquired in routine non-invasive clinical procedures either as directly captured digital images or digitized analogue ones. Important morphological parameters, such as cup to disc surfaces ratios, have been directly measured in the images by the professional image processing software. The values of the fractal dimensions for the image textures have been estimated both in the space and frequency domains. They are treated as additional classifying parameters, describing the complexity of retinal patterns. All the collected data - the fundus images and their characteristics - both for hospital patients and a control group have been described according to the approved medical standards. A proper database management environment, being crucial in performing appropriate comparison, queries and data classification has been set up. Pilot results with preliminary statistical analysis are presented and discussed.


    1880/2523

    Tytuł oryginału: The phanton image quality, the average gandular dose and the overal number of examinations as a measure of evaluation of a mammography facility.
    Autorzy: Tołwiński Jerzy, Fabiszewska Ewa
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (2) s.99-106, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of the study were the measurements and calculations of the phantom image quality, the average glandular dose and the overal number of examinations as a measure of evaluation of a mammography facility. The image quality estimation was based on the evaluation of the images of a phantom designed for accreditation purposes by the American College of Radiology (ACR). The following parameters were assessed: the number of visible phantom structures, the contrast between the acrylic ring in the phantom and its surrounding, the phantom background level and the number of visible artefacts. The mean phantom doses were measured with a Diados dosimeter (PTW). The measurements of individual patients doses were made using the same methods and definitions as those used for mean phantom dose determinations, but related to parameters of the examination of an individual patient. The overall number of examinations performed on a mammography unit was used for the evaluation of a mammography facility in Poland. The data induced the number of examinations in Poland in 1997, and those in Warsaw in 1997-1999. This study is based on protocols of the quality control (published in the Mammography Quality Manual (ACR) for 37 mammography units. The image quality in a large majority of cases exceeded the tolerance limit (only 4 of 37 met the necessary requirements). In all mammographs tested, the values of the mean phantom doses (3 mGy) were lower than this value. Individual dose distributions can be a measure of controlling the conditions under which mammography examinations are performed, pointing...


    1881/2523

    Tytuł oryginału: Studies on the time and temperature dependencies of the water solubility of the irradiated bovine bone.
    Autorzy: Pankowski Edward, Kubisz Leszek
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (2) s.107-113, il., bibliogr. 7 poz.
    Sygnatura GBL: 306,499

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: Measurements of the solubility of bone material were made over the range of 20-70řC. The degree of solubility and concentration of the dissolved material was measured as a function of dose, temperature and duration of the dissolution process. The irradiated material was dissolved in distilled water. The degree of solubility and the concentration of the dissolved material were dose and temperature-dependent. For the dose of 500 kGy, the highest rate of the dissolution process was observed during the first three hourse at a temperature of 20řC. About 10 p.c. of the initial mass of the bone was dissolved at a temperature of 30řC and about 20 p.c. at a temperature of 70řC.


    1882/2523

    Tytuł oryginału: Activity measurement and analysis of breathing, using a microcontroller and an infrared data link.
    Autorzy: Pietraszek Stanisław, Altmajer Mariusz
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (2) s.115-119, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The breathing activity recorder uses three miniature thermistor sensors to detect a flow of air during inspiration and expiration. Changes in sensors, resistance with temperature are converted into voltage and digitized in a 10-bit A/D converter. Detection of the breath is done by microcontroller PIC16F877. Detection algorithm is based on the comparison of the actual signal amplitude with the threshold level. Samples of the signal are transmitted to a host computer via an infrared data link using a IrDA standard. A delicated receiver powered from computer port lines, converts a specific 10-bit data format to two 8-bit words in a RS-232 standard. Data displayed on the screen are stored in a simple database. The algorithm for detection of the breath is similar to that in a microcontroller, however is performed again on line on the raw data. Such a solution allows using much more sophisticated and precise computation than that applied in a simple 8-bit processor unit.


    1883/2523

    Tytuł oryginału: The effect of peroxisome proliferator-activated receptors ŕ (PPARŕ) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity, and plasma paraoxonase 1 (PON1) activity.
    Autorzy: Bełtowski J[erzy], Wójcicka G., Mydlarczyk M., Jamroz A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.463-475, il., bibliogr. 52 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of this study was to investigate the effect of peroxisome proliferator activated receptors ŕ agonist, fenofibrate, on the level of oxidative stress, total antioxidant capacity, and plasma paraoxonase 1 (PON1) activity in the rat. The adult male Wistar rats received fenofibrate for 7 days. The drug was added to food at concentrations 0.005 p.c., 0.05 p.c. and 0.5 p.c., which corresponded to doses of 3, 30 and 300 mg/kg/day, respectively. Fenofibrate treatment dose-dependently reduced plasma concentration of malonyldialdehyde and 4-hydroxydialkenals. The level of these lipid peroxidation products in animals treated with 0.005 p.c., 0.05 p.c. and 0.5 p.c. fenofibrate was lower than in control group by 52.8 p.c., 62.7 p.c. and 87.1 p.c. respectively. Lipid hydroperoxides in plasma decreased by 29.7 p.c., 23.4 p.c and 27.5 p.c. in these groups, respectively. The drug had no significant effect on total antioxidant capacity measured as ferric reducing ability of plasma (FRAP). Paraoxonhydrolyzing activity (PON) of plasma paraoxonase was 81.5 p.c. lower in animals receiving 0.05 p.c. fenofibrate and 69.2 p.c. lower in rats treated with 0.5 p.c. fenofibrate than in control. Phenyl acetate hydrolyzing aactivity (arylesterase, AE) was reduced by 15.2 p.c., 49.6 p.c. and 55.8 p.c. in rats receiving 0.005 p.c., 0.05 p.c. and 0.5 p.c. fenofibrate, respectively. PON/AE ratio decreased following 0.05 p.c. and 0.5 p.c. fenofibrate by 64.9 p.c. and 30.4 p.c. respectively. The drug had no significant effect on total plasma triyglycerides and cholesterol concentrations...


    1884/2523

    Tytuł oryginału: Correlation of the -3826A G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland.
    Autorzy: Kieć-Wilk B., Wybrańska I., Malczewska-Malec M., Leszczyńska-Gołąbek I., Partyka Ł., Niedbał S., Jabrocka A., Dembińska-Kieć A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.477-490, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to examine the allelic frequency of the -3826A G mutation of UPC1 in patients with familar obesity and to investigate putative association of this polymorphism with metabolic disorders. One hundred and eighteen overweight / obese patients participated in the study. The UCP1 polymorphism was determined by RFLP. Glucose, lipid, insulin and leptin levels were measured both during OGTT and OLTT. The majority of patients had a homozygous A/A genotype (51,38 p.c.), while 14,68 p.c. had a G/G genotype. We found no significant association of the Gallele with either BMI or glucose tolerance. Patients with the homozygous G/G genotype had significantly higher fasting levels of TG (p 0.04) and decreased levels of HDL-cholesterol (p = 0,004). They also had an increased concentration of FFA and the rise of TG levels during the OLTT compared to controls was significant (p = 0,058). In addition, the carries of the G/G genotype had the lowest insulin levels both during OGTT and OLTT. In our study we have demonstrated that the -3826A G polymorphism of UCP1 does not play a major role in the development of obesity and/or disturbances of glucose metabolism. However, the increased levels of TG and FFA and decreased levels of HDL observed in carriers of the G allele suggest FFA-induced impairment of the HDL turnover and disturbance of the á-cell function, both of which are risk factors for endothelial injury.


    1885/2523

    Tytuł oryginału: Poly(ADP-ribose) polymerase activity in the cat carotid body in hypoxia and hyperoxia.
    Autorzy: Strosznajder R. P., Jesko H., Pokorski M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.491-496, il., bibliogr. 16 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • koty
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Reactive oxygen species (ROS) induce DNA damage with the ensuing activation of the chromosomal repair enzyme poly(ADP-ribose) polymerase (PARP). ROS also interact with the function of carotid body chemoreceptor cells. The possibility arises that PARP is part of the carotid chemosensing process. This study seeks to determine the presence of PARP and its changes in response to contrasting chemical stimuli, hypoxia and hyperoxia, both capable of generating ROS, in cat carotid bodies. The organs were dissected from anesthetized cats exposed in vivo to acute normoxic (PaO2 ÷ 25 mmHg), and hyperoxic (PaO2 400 mmHg) conditions. Carotid body homogenate was the source of PARP and [adenine 14C] NAD was the substrate in the assay. Specimens of the superior cervical ganglion and brainstem were used as reference tissues. We found that PARP activity amounted to 27 pmol/mg protein/min in the normoxic carotid body. The activity level more than doubled in both hypoxic and hyperoxic carotid bodies. Changes of PARP in the reference tissues were qualitatively similar. We conclude that PARP is present in the carotid body but the augmentation of the enzyme activity in both hypoxia and hyperoxia reflects DNA damage, induced likely by ROS and being universal for neural tissues, rather than a specific involvement of PARP in the chemosensing process.


    1886/2523

    Tytuł oryginału: Will therapeutic cloning someday offer hope for severe mental illness?
    Autorzy: Dattilio Frank M.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.5-8, bibliogr. 4 poz.
    Sygnatura GBL: 313,554

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa


    1887/2523

    Tytuł oryginału: The association study of a functional polymorphism of the monoamine oxidase A gene promoter in patients with affective disorders.
    Autorzy: Hauser Joanna, Leszczyńska Anna, Samochowiec Jerzy, Ostapowicz Agata, Czerski Piotr, Jaracz Jan, Suwalska Aleksandra, Horodnicki Jan, Rybakowski Janusz
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.9-15, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Recently a functional 30 bp variable number of tandem repeat polymorphism (VNTR) in the promoter region of the MAO-A gene was identified, which was shown to be associated with MAO-A transcriptional activity. Variation in the number of repeats (3 - 5) displayed a 2.7 - 4.8 fold increased transcription activity for allele containing four or five repetitive elements than allele containing three repectitive elements. In the present study we investigated this polymorphism in 78 male and 122 female patients with bipolar and unipolar affective disorders, and in 221 control subjects. There were significant differences in the alleles and genotypes frequencies between the group of females with bipolar affective illess compared to the controls and compared to the unipolar female subjects. No differences were found in genotype distribution between unipolar female patients and control group and between bipolar and unipolar male subjects comparing to the controls. We suggest that the association may exist between uVNTR polymorphism in MAO A gene and bipolar affective disorders in women.


    1888/2523

    Tytuł oryginału: Interaction of monoamine transporter genes and personality dimensions.
    Autorzy: Rybakowski Filip, Samochowiec Jerzy, Zakrzewska Marzena, Czerski Piotr, Stępień Genowefa, Pełka-Wysiecka Justyna, Hauser Joanna, Horodnicki Jan, Rajewski Andrzej, Rybakowski Janusz K.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.17-24, tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • genetyka
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: There is evidence for an association between allelic wariants of the monoamine transporter genes and the temperamental personality traits. Recent findings show that also an interaction of the different genes may contribute to the personality factors. Character dimensions of personality, which theoretically depend mainly on the ontogenetic development, were suggested to be under the genetic influence as well. We studied the association between personality dimensions measured with Temperament and Character Inventory (TCI) and polymorphism of the dopamine (DAT), norepinephrine (NET) and serotonin (5-HTT) transporter genes. The sample studied consisted of 128 healthy volunteers: 76 females and 52 males, mean age 23.8 ń 1.7 years, derived from two cities in the western part of Poland. We found statistically significant association between character dimension of Self-Directedness (SD) and NET polymorphism. There was a statistically significant effect of the interaction of NET and DAT polymorphisms on the dimension of Self-Transcedence (ST). The temperamental dimension of Reward Dependence (RD) was associated with interaction of 5-HTT and DAT polymorphisms. Character dimensions of personality, Self-Directedness and Self-Transcendence were associated with genetic differences. Interaction effect of the transporter polymorphisms was demonstrated in the Self-Transcendence and Reward Dependence dimensions. These findings warrant further study on the interplay of the different genes contributing to the complex traits.


    1889/2523

    Tytuł oryginału: Comparison of properties of chelating surbents prepared by modification of silica gel or LiChroprep rp-8 with Acid Orange 8.
    Tytuł polski: Porównanie właściwości sorbentów chelatujących otrzymanych przez modyfikację żelu krzemionkowego lub LiChroprepu RP-8 kwasem oranżowym 8.
    Autorzy: Kocjan Ryszard, Sowa Ireneusz
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.9-17, il., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1890/2523

    Tytuł oryginału: Chromatographic parameters as predictors of biological lipophilicity of 2,4-dihydroxythiobenzanilide derivatives.
    Tytuł polski: Paramtery chromatograficzne jako wyznaczniki przewidywania biologicznej lipofilowości 2,4-dihydroksytiobenzanilidów.
    Autorzy: Jóźwiak Krzysztof, Szumiło Halina
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.19-24, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1891/2523

    Tytuł oryginału: Determination of zinc, cobalt, manganese and copper content in some herbal plants.
    Tytuł polski: Badanie zawartości cynku, kobaltu, manganu i miedzi w niektórych roślinach zielarskich.
    Autorzy: Blicharska Eliza, Kocjan Ryszard, Sowa Ireneusz
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.25-30, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1892/2523

    Tytuł oryginału: Analysis of fatty acids in human breast milk by off-line tandem technique Af-TLC/GC.
    Tytuł polski: Analiza kwasów tłuszczowych w mleku ludzkim przy pomocy technik połączonych off-line Ag-TLC/GC.
    Autorzy: Flieger Jolanta, Szumiło Halina
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.31-38, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1893/2523

    Tytuł oryginału: Synthesis of 5-arylidene-2,4-dioxothiazolidin-3-yl alkanoic acids.
    Tytuł polski: Synteza kwasów 5-arylideno-2,4-dioksotiazolidyno-3-il alkanowych.
    Autorzy: Leksyk Roman, Zimenkovsky Boris, Troc'ko Nazar, Kazmirchuk Genadij
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.39-45, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1894/2523

    Tytuł oryginału: Wpływ magnezu, miedzi i ołowiu podawanych w wodzie do picia na stężenie magnezu i wapnia w tkankach szczurów z doświadczalną hipertyreozą.
    Tytuł angielski: The influence of magnesium, copper and lead in drinking water of rats with experimental hyperthyroidism on the magnesium and calcium tissue concentration.
    Autorzy: Pasternak Kazimierz, Bielak Ewa, Kiełczykowska Małgorzata
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.47-53, tab., bibliogr. 23 poz., sum.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    1895/2523

    Tytuł oryginału: Reakcja 4-(2-pirydylo)-tiosemikarbazydu kwasu izonikotynowego, nikotynowego, pikolinowego i benzoesowego z omega-bromoacetofenonem.
    Tytuł angielski: The reaction of 4-(2-pyridyl)-thiosemicarbazide of isonicotinic, nicotinic, picolinic and benzoic acid with omega-bromacetophenone. [P.] 3.
    Autorzy: Marcewicz-Rojewska Barbara
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.65-70, il., bibliogr. 8 poz., sum.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1896/2523

    Tytuł oryginału: The metabolism of L-rhamnose in Mycobacterium smegmatis. [P.] 2: L-rhamnulose kinase.
    Tytuł polski: Metabolizm L-ramnozy w Mycobacterum smegmatis.
    Autorzy: Miazga-Karska Małgorzata, Zalewska Justyna
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.89-97, il., tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny


    1897/2523

    Tytuł oryginału: Some catalytic properties of erythrulose kinase from Mycobacterium smegmatis.
    Tytuł polski: Niektóre katalityczne właściwości kinazy erytrulozy z Mycobacterium smegmatis.
    Autorzy: Paradowska Katarzyna, Szumiło Tadeusz
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.99-105, il., tab., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1898/2523

    Tytuł oryginału: Induction and substrate specificity of erythritol dehydrogenase from Mycobacterium smegmatis ATCC 20.
    Tytuł polski: Indukcja i specyficzność substratowa dehydrogenazy erytrytolowej z Mycobacterium smegmatis ATCC 20.
    Autorzy: Paradowska Katarzyna, Swatko Marta
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.107-112, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1899/2523

    Tytuł oryginału: Occurrence of some pathogenic microorganisms on the mucous membranes of the nose and/or throat in healthy young children.
    Tytuł polski: Występowanie patogennych drobnoustrojów na błonach śluzowych nosa i/lub gardła u zdrowych dzieci w wieku przedszkolnym.
    Autorzy: Malm Anna, Kosikowska Urszula, Korona-Głowniak Izabela, Tynecka Zofia
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.113-119, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • płeć męska
  • płeć żeńska


    1900/2523

    Tytuł oryginału: Some biochemical properties and drug susceptibility of Staphylococcus aureus strains isolated from mucous membranes of the upper respiratory tract of healthy young children and elderly people.
    Tytuł polski: Niektóre właściwości biochemiczne oraz lekowrażliwość szczepów Staphylococcus aureus izolowanych z błon śluzowych górnych dróg oddechowych u zdrowych dzieci w wieku przedszkolnym oraz osób starszych.
    Autorzy: Malm Anna, Kasprzycka Anna, Tynecka Zofia
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.121-129, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • płeć męska
  • płeć żeńska


    1901/2523

    Tytuł oryginału: Synthesis of new derivatives of 7-arylsulfonyl-3(2H)-oxo, thioxo, imino-5-oxo-6,7-dihydroimidazo[2,1-c][1,2,4]triazole.
    Tytuł polski: Synteza nowych pochodnych 7-arylosulfonylo-3(2H)-oxo, tiokso, imino-5-okso-6,7-dihydroimidazo[2,1-c][1,2,4]triazolu.
    Autorzy: Rządkowska Marzena, Sztanke Krzysztof
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.169-172, il., tab., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1902/2523

    Tytuł oryginału: Synteza nowych pochodnych 3-fenoksymetylo-7-arylo-5H-6,7-dihydroimidazo[2,1-c][1,2,4]triazolu.
    Tytuł angielski: Synthesis of new derivatives of 3-phenoxymethyl-7-ary-5H-6,7-dihydroimidazo[2,1-c]j[1,2,4]triazole.
    Autorzy: Sztanke Krzysztof, Rządkowska Marzena
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.173-176, il., tab., bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1903/2523

    Tytuł oryginału: Cyclocondensation of 7-aryl-3-hydrazino-5H-6,7-dihydroimidazo 2,1-c][1,2,4]triazoles to a novel heterocyclic ring system of 1,2,4-triazolo[3',4':5,1]1,2,4-triazolo[4,3-a]imidazole.
    Tytuł polski: Cyklokondensacja 7-arylo-3-hydrazyno-5H-6,7-dihydroimidazo[2,1-c][1,2,,4]triazoli do nowego układu heterocyklicznego 1,2,4-triazolo[3',4',5,1]1,2,4-triazolo[4,3-a]imidazolu.
    Autorzy: Sztanke Krzysztof
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.177-179, il., tab., bibliogr. 2 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1904/2523

    Tytuł oryginału: Synthesis of new dimethyl 3-(1-aryl-deltaý-imidazolin-2-ylhydrazono)glutarate derivatives.
    Tytuł polski: Synteza nowych pochodnych estru dimetylowego kwasu 3-(1-arylo-deltaý-imidazolino-2-ylohydrazono)glutarowego.
    Autorzy: Sztanke Krzysztof
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.181-184, il., tab., bibliogr. 3 poz., sum.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1905/2523

    Tytuł oryginału: Further studies on the role of nitric oxide (NO) in endurance exercised rats.
    Tytuł polski: Dalsze badania nad rolą tlenku azotu u szczurów poddanych wysiłkowi fizycznemu do wyczerpania.
    Autorzy: Frankiewicz-Jóźko Anna, Grudziński Ireneusz P.
    Źródło: Med. Sport. 2002: 18 (11) s.462-465, tab., bibliogr. 17 poz., streszcz. - 25 Kongres Polskiego Towarzystwa Medycyny Sportowej Warszawa 12-14.09. 2002
    Sygnatura GBL: 313,155

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Wstęp. Znany jest fakt, że peroksydacja lipidów może być zwiększona w mięśniach szkieletowych oraz mięśniu sercowym szczurów po intensywnym wysiłku fizycznym oraz, że ten niekorzystny efekt może być związany z produkcją reaktywnych form tlenu i azotu (RONS). Chociaż tlenek azotu (NO) posiada właściwości antyoksydacyjne, związek rownież wykazywał prooksydacyjne działanie w następstwie tworzenia peroksyazotynu (ONOO) w reakcji z rodnikiem ponadtlenkowym (O2). W większości przypadków, niskie stężenia NO wystarczają dla utrzymania jego podstawowych funkcji fizjologicznych takich jak kontrola ciśnienia krwi, transmisja sygnałów neuronalnych czy skurcze mięśni. Duże stężenia NO były natomiast wykazywane w stanach prozapalnych, sugerując między innymi, że NO i/lub jego pochodne red-ox mogą być czynnikiem ryzyka peroksydacji lipidów. Ostatnie badania prowadzone w naszym laboratorium pokazały, że inhibitory syntazy tlenku azotu (NOS), tj. ester metylowy Nw-nitro-L-argininy (L-NAME; 10 mg/kg m.c.) nie wpływał na poziom peroksydacji lipidów u szczurów po wysiłku fizycznym. Dlatego w obecnych badaniach postanowiliśmy zwiększyć dawkę L-NAME w celu oceny potencjalnego wpływu endogennego tlenku azotu (NO) na indukowaną wysiłkiem peroksydację lipidów w wątrobie oraz mięśniach nietrenowanych szczurów. Materiał i metody. Badania wykonano na nietrenowanych szczurach, samcach szczepu Wistar (200 ń 10 g). Podczas doświadczeń, zwierzęta były przetrzymywane w warunkach standardowych oraz karmione dietą (Murigran) i wodą ad libitum...

    Streszczenie angielskie: Effects of endogenous nitric oxide (NO) from L-arginine on thiobarbituric acid reactive substances (TBARS), a marker of lipid peroxidation, were studied in untrained rats subjected to endurance treadmil running following a single oral dosage of nitric oxide synthase (NOS) inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME; 30 mg/kg b.w.). Results showed that L-NAME mitigated exercise-induced TBARS in the heart, liver soleus as well as red part of gastrocnemius muscle, however it was also found to reduce animal capacities to perform exercise running. Present studies suggest that the endurance exercise of untrained rats is enabled to induce lipid peroxidation and/or pro-oxidant shift(s) in NOS-linked processes.


    1906/2523

    Tytuł oryginału: Identyfikacja i charakterystyka genów - kandydatów w miażdżycy. Rola lizofosfolipidów w regulacji genów makrofagowych : praca doktorska
    Autorzy: Schmitz-Mądry Anna, Naruszewicz Marek (promot.).; Pomorska Akademia Medyczna Katedra Biochemii Klinicznej i Diagnostyki Laboratoryjnej w Szczecinie, Uniwersytet Instytut Chemii Klinicznej i Medycyny Laboratoryjnej w Regenesburgu
    Źródło: 2002, [2], XIII, 377 k : il., tab., bibliogr. k. 358-377, sum., maszyn.
    Sygnatura GBL: 45/20667

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • praca doktorska
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1907/2523

    Tytuł oryginału: Coronary microcirculation and reperfusion failure. Do we know what diagnostic tools we have?
    Tytuł polski: Mikrokrążenie wieńcowe i nieskuteczna reperfuzja - jakie mamy metody diagnostyczne?
    Autorzy: Zorkun Cafer, Żmudka Krzysztof, Dudek Dariusz, Przewłocki Tadeusz, Trębacz Jarosław, Musiałek Piotr, Pieniążek Piotr, Zalewski Jarosław, Gajos Grzegorz, Legutko Jacek, Kapelak Bogusław, Podolec Piotr, Pasowicz Mieczysław, Sadowski Jerzy, Dubiel Jacek, Pawlik Wiesław
    Źródło: Prz. Lek. 2002: 59 (11) s.932-940, il., bibliogr. 123 poz., sum.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Angiografia naczyń wieńcowych połączona z echokardiografią kontrastową wykazały, że w ostrym zawale serca drożność tętnicy dozawałowej nie zawsze przekłada się na obecność prawidłowej perfuzji miokardium w obszarze zaopatrywanym przez tą tętnicę. Zjawisko to, występujące u co 5 pacjenta z ostrym zawałem serca, określono jako "nieskuteczna reperfuzja" (reperfusion failure). Pilnie potrzebne jest rozwijanie i wdrożenie nowych metod rozpoznawania nieskutecznej reperfuzji i oceny mikrokrążenia wieńcowego. Do metod badanych aktualnie w praktyce klinicznej należą (1) czas rezolucji odcinka ST (ST segment resolution time), (2) skala przepływu wieńcowego TIMI (TIMI flow grade), (3) skorygowana liczba klatek w sklai TIMI (TIMI Frame Count), oraz (4) szybkość wychwytu środka kontrastowego przez miokardium (TIMI miocardial perfusion grade = "blush score").

    Streszczenie angielskie: Almost one in five patient has reperfusion abnormalities despite the type of percutaneous interventional procedure after acute myocardial ifnarction. It has been shown with myocardial contrast echocardiographic and coronary angiographic studies that infarct related artery patency does not always correlate with the presence of adequate myocardial perfusion in the infarct related artery territory. Therefore, ti is necessary to obtain futher diagnostic and evaluation tools to assess coronary microcirculation and reperfusion failure. ST segment resolution time, TIMI flow grade, TIMI Frame Count and TIMI Myocardial Perfusion Grade (blush score) are helpful tools to assess myocardial perfusion and diagnosis of reperfusion abnormalities.


    1908/2523

    Tytuł oryginału: Professor Zdzisław Kleinrok, D.Sc., M.D., D.H.C. mult. (1928-2002). Obituary.
    Autorzy: Wielosz Marian, Żebrowska-Łupina Iwona
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.553-555, il.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Kleinrok
  • Zdzisław 1928-2002


    1909/2523

    Tytuł oryginału: Neuroprotective effects of an antiepileptic drugs.
    Autorzy: Trojnar Michał K., Małek Robert, Chrościńska Magdalena, Nowak Stanisław, Błaszczyk Barbara, Czuczwar Stanisław J.
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.557-566, tab., bibliogr. 70 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • króliki
  • myszy
  • szczury
  • in vitro

    Streszczenie angielskie: Experimental and clinical data indicate that epilepsy and seizures lead to neuronal cell loss and irreversible brain damage. This neurodegeneration results not only in the central nervous system dysfunction but may also be responsible for the decreased efficacy of some antiepileptic drugs (AEDs). The aim of this review was to assemble current literature dat on neuroprotective properties of AEDs. The list of hypothetical neuroprotectants is long and consists of substances which act via different mechanisms. We focus on AEDs since this heterogenous group of pharmaceuticals, as far as mechanisms of their action and mechanisms of neuronal death are concerned should provide protection in addition to antiseizure effect itself. Most studies on neuroprotection are based on animal experimental models of neuronal degeneration. Electrically and pharmacologically evoked seizures as well as different models of ischemia are frequently used. Algtough our knowledge about properties of AEDs is still not complete and discrepancies ocassionally occur, the group seems to be promising in terms of neuroprotection. Some of the drugs, though, turn out to be neutral or even have adverse effects on the central nervous system, especially on immature brain tissue (barbiturates and benzodiazepines). Unfortunatelly, we cannot fully extrapolate animal data to humans, therefore further well designed clinical trials are necessary to determine neuroprotective properties of AEDs in humans. However, there is a hope that AEDs will have potential to severe as neuroprotectants not only in seizures, but...


    1910/2523

    Tytuł oryginału: Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines.
    Autorzy: Antkiewicz-Michaluk Lucyna
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.567-572, bibliogr. 20 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • in vitro

    Streszczenie angielskie: The cause of chronic nigral cell death in Parkinson's disease (PD) and the underlying mechanisms remain elusive. The selective action of exogenous and endogenous neurotoxic substances can provide partial explanation of these processes. 1-Methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an exogenous neurotoxin producing parkinsonism in humans, monkeys and various animals as the result of MAO B-catalyzed conversion of it to the 1-methyl-4-phenyl-pyridinum ion (MPP+), which selectively kills the nigrostriatal dopaminergic neurons. On the other hand, various isoquinoline derivatives were found in the brain, and they considered to be the endogenous neurotoxins with neurochemical properties similar to those of MPTP, which cause PD. Among them, 1,2,3,4-tetrahydroisoquinoline (TIQ), 1-benzyl-TIQ, and 1-methyl-5,6-dihydroxy-TIQ (salsolinol) have the most potent neurotoxic action. Since PD is a slowly progressing neurodegenerative disease, it has been suggested that is could be connected with excitotoxicity and apoptosis. Therapeutic strategies should focused on the search for the drugs exhibiting antiapoptotic potential such as: antioxidants, MAO B inhibitors, dopaminergic drugs and free radical scavengers.


    1911/2523

    Tytuł oryginału: Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.
    Autorzy: Graumann Rebecca, Paris Irmgard, Martinez-Alvorado Pedro, Rumanwue Pamela, Perez-Pastene Carolina, Cardenas Sergio P., Marin Pablo, Diaz-Grez Fernando, Caviedes Raul, Caviedes Pablo, Segura-Aguilar Juan
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.573-579, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: Although it is generally accepted that free radicals are involved in the neurodegenerative process occurring in the dopaminergic neurons of the nigro-striatal system in Parkinson's disease, the exact mechanims of neurodegeneration in vivo is still unknown. We propose that the degeneration of dopaminergic nigrostriatal system in this condition may depend on: (a) existence of free dopamine which oxidizes to aminochrome as a consequence of: (i) overproduction of dopamine, (ii) inhibition and/or low expression of synaptic vesicle catecholamine transporter, (iii) inhibition or low expression of monoamine oxidases; (b) one-electron reduction of aminochrome to leukoaminochrome o-semiquinone radical, which induces neurotoxicity, due to inhibition of DT-diaphorase or the existence of a polymorphism wiht a point mutation (C- T) in the cDNA 609 expressing an inactive DT-diaphorase. We suggest that DT-diaphorase plays an neuroprotective role in dopaminergic neurons, which is supported by the following observations: (i) Cu-toxicity is dependent on DT-diaphorase inhibition with diocoumarol in RCSN-3 cells derived from the substantia nigra, (ii) the cytotoxic effect of monoamine oxidase-A inhbitor amiflamine in RCSN-3 cells is increased by 2.4-fold (p 0.001) in the presence of the inhibitor of DT-diaphorase, dicoumarol, (iii) concomitant intracerebral administration of manganese (Mn3+) together with the DT-diaphorase inhibitor dicoumarol into the left medial forebrain bundle produced a behavioral pattern characterized by contralateral rotational behavior when the rats were stimulated...


    1912/2523

    Tytuł oryginału: On the role of metabotropic glutamate receptors in the mechanisms of action of antidepressants.
    Autorzy: Pałucha Agnieszka, Pilc Andrzej
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.581-586, bibliogr. 50 poz., sum.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Most conventional antidepressant drugs influence serotoninergic adrenergic, and/or dopaminergic systems, increasing serotonin, norepinephrine and dopamine synaptic availability. More recently has focused on glutaminergic system. Both preclinical and clinical studies, showing antidepressant-like actions of compounds which reduce transmission at N-methyl-D-aspartate (NMDA) receptors, indicate possible involvement of glutamatergic system in the etiology of depression. Since glutamatergic transmission is controlled not only by inotropic but also by metabotropic glutamate receptors (mGluR), their involvement in the etiology and the therapy of depression was also postulated. Recent studies, showing that antidepressant treatment may influence mGlu receptors, together with the findings that group I mGluR antagonists, may possess antidepressant-like action, support this hypothesis.


    1913/2523

    Tytuł oryginału: Mechanisms contributing to antidepressant zinc actions.
    Autorzy: Nowak Gabriel, Szewczyk Bernadeta
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.587-592, tab., bibliogr. 33 poz., sum.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • szczury

    Streszczenie angielskie: Zinc is a trace element, which is an important modulator of mammalian nervous and immune systems. Its deficiency is related to human depression. Our recent data indicate involvement of zinc in the mechanism of antidepressant treatment. Moreover, zinc exhibits antidepressant-like effects in animal models of depression in rodents. Since zinc also enhances antidepressant effect in laboratory animals, its potential therapeutic value in human depression is under evaluation. This article reviews the alterations in central and peripheral zinc homeostasis in relation to pathophysiology and treatment of depression.


    1914/2523

    Tytuł oryginału: Effect of repeated treatment with reboxetine on the central ŕ1-adrenergic and dopaminergic receptors.
    Autorzy: Rogóż Zofia, Margas Wojciech, Skuza Grażyna, Solich Joanna, Kuśmider Maciej, Dziedzicka-Wasylewska Marta
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.593-603, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Reboxetine (REB) is a member of a new class of antidepressants drugs, which selectively inhibit the neuronal reuptake of noradrenaline. It is devoid of any affinity for neurotransmitter receptors nor does it inhibit monoamine oxidases A or B. Since our earlier studies have shown that antidepressant drugs administered repeatedly increase the responsiveness of ŕ1-adrenergic receptors and induce the up-regulation of postsynaptic dopamine D2/D3 receptors in the rat brain, we designed the present experiments to determine whether repeated administration of REB evokes similar effects. The experiments were carried out on male Wistar rats. REB was administered at a dose of 10 mg/kg (or 30 mg/kg in some cases) once or repeatedly (twice daily for 14 days). The obtained results show that REB administered repeatedly increased exploratory behavior induced by phenylephrine and potentiated the hyperlocomotion induced by D-amphetamine. These behavioral effects indicate the hyperresponsiveness of 1-adrenergic receptors. Biochemical studies did not show any changes in the binding parameters of [3H]prazosin (Bmax or Kd), but the ability of the ŕ1-adrenergic receptor agonist, phenylephrine, to complete for these sites was significantly increased upon repeated administration of REB. Locomotor activity induced by quinpirole was not changed, although there was a potentiation of 7-OH-DPAT-induced locomotor hypereactivity in rats receiving repeated administration of REB. At the same time no significant changes in the binding of [3H]quinpirole and [3H]7-OH-DPAT, or at the level of mRNA...


    1915/2523

    Tytuł oryginału: Role of neuropeptides in antidepressant and memory improving effects of venlafaxine.
    Autorzy: Nowakowska Elżbieta, Kus Krzysztof, Bobkiewicz-Kozłowska Teresa, Hertmanowska Hanka
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.605-613, il., tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aim of this study has been to investigate the effects of vasopressin and oxytocin on antidepressive and memory improving effects of venlafaxine. Male Wistar rats weighting 180-2000 g were used in the study. Venlafaxine (20 mg/kg) was administered po 30 min before the test once, and for 7 and 14 days in the chronic experiments. Oxytocin (1 ćg/kg) ip and vasopressin (1 ćg/kg) sc were administered only once on the test day, 60 min before the tests. The animals were subjected to Porsolt's test for testing antidepressant activity, and their memory functions (working and spatial memory) were evaluated in the maze test and Morris Water Maze test. Antidepressant effects of venlafaxine could be observed already after single drug administration and the effect was maintained during 7 days of drug administration. Oxytocin also exhibited antidepressant activity, and concurent administration of venlafaxine and oxytocin helped to maintain antidepressant activity of venlafaxine. Vasopressin was devoid of antidepressant action, yet concurrent administration of vasopressin and venlafaxine did not suppress antidepressant activity of the latter. In the chronic experiment, there was no shortening of passive swimming time. Venlafaxine improved memory in the labyrinth test and in the spatial memory test, whereas oxytocin did not affect memory of the tested animals. Joint administration of venlafaxine and oxytocin did not produce memory improving effect observed after administration of venlafaxine only. Vasopressin improved memory and joint administration of venlafaxine and vasopressin...


    1916/2523

    Tytuł oryginału: Effects of combined administration of 5-HT 1A and/or 5-HT 1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats.
    Autorzy: Tatarczyńska Ewa, Kłodzińska Aleksandra, Chojnacka-Wójcik Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.615-623, tab., bibliogr. 58 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Clinical data suggest that coadministration of pindolol, a 5-HT 1A/5-HT 1B/ á-adrenoceptor antagonist, and selective serotonin reuptake inhibitors (SSRIs) may shorten the time of onset a clinical action and may increase beneficial effects of the therapy of drug-resistant depression. Effects of combined administration of SSRIs and 5-HT receptor ligands are currently evaluated in animal models for the detection of an antidepressant-like activity; however, the obtained results turned out to be inconsistent. The aim of the present study was to investigate effects of a 5-HT 1A antagonist (WAY 100635), 5-HT 1B antagonists (SB 216641 and GR 127935) or pindolol, given in combination with parotexine or fluoxetine (SSRIs), in the forced swimming test in rats (Porsolt test). When given alone, paroxetine (10 and 20 mg/kg), fluoxetine (10 and 20 mg/kg), WAY 100635 (0.1 and 1 mg/kg), SB216641 (2 mg/kg), GR 127935 (10 and 20 mg/kg) and pindolol (4 and 8 mg/kg) did not shorten the immobility time of rats in that test. Interstingly, SB 216641 administered alone at a dose of 4 mg/kg produced a significant reduction of the immobility time in that test. A combinationt of paroxetine (20 mg/kg) and WAY 1000635 or pindolol failed to reveal a significant interaction; on the other hand, when paroxetine was given jointly with SB 216641 (2 mg/kg) or GR 127935 (10 and 20 mg/kg), that combination showed a significant antiimmobility action in the forced swimming test in rats. The active behaviors in that test did not reflect increased general activity because combined administration of both the...


    1917/2523

    Tytuł oryginału: Inhibition of amino acid release by 5-HT 1B receptor agonist in the rat prefrontal cortex.
    Autorzy: Gołembiowska Krystyna, Dziubina Anna
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.625-631, il., bibliogr. 43 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: In vivo microdialysis in consious rats were used to evaluate the effect of 5-HT 1A agonist (ń)-8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT), 5-HT 2A/2C agonist (ń)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and 5-HT 1B receptor agonist 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo-[3,2-b]pyrid-5-one (CP 93129) on the veratridine-evoked glutamate (Glu) and aspartate (Asp) release in the rat prefrontal cortex. CP 93129 at concentrations between 50-500 ćM significantly reduced Glu and Asp release. The effect of CP 93129 was attenuated by intraperitoneal (ip) administration of the selective 5-HT 1B receptor antagonist N-[3-[3-(dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide (SB 216641) at a dose of 2 mg/kg. Neither DOI (100 ćM) nor 8-OH-DPAT given locally at concentration of 100 ćM or peripherally at doses of 0.1 and 1 mg/kg ip, influenced stimulated Glu and Asp release. We suggest that cortical glutamatergic neurons possess 5-HT 1B heteroceptors and their activation may be responsible for the inhibitory effect of 5-HT on Glu and Asp release.


    1918/2523

    Tytuł oryginału: Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes.
    Autorzy: Roman Adam, Vetulani Jerzy, Nalepa Irena
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.633-639, il., bibliogr. 35 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • immunologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Depression is associated with abnormal functions of the immune system. In this study, we investigated how two modern antidepressant therapies, chronic treatment with transcranial magnetic stimulation (TMS) and administration of an antidepressant belonging to selective serotonin reuptake inhibitors (SSRI), paroxetine, affect the proliferative response of thymocytes and splenocytes stimulated in vitro with various mitogens. Paroxetine (10 mg/kg) and TMS (B=1.2 T, f= 30 Hz, t=330 s) were applied once daily for 12 consecutive days, while, if given jointly paroxetine was injected 30 min before TMS. The mitogens used were: concanavalin A (Con A), pokeweed mitogen (PWM) or lipopolysaccharide (LPS). While either treatment applied alone had no effect on proliferative response, the joint application of paroxetine and TMS significantly depressed it. The literature data suggest that pulsed magnetic field may directly inhibit mitogen-activated lymphocyte proliferation, which is also inhibited by the presence of high level of serotonin. The present results suggest that both effects are additive, and because of that application of both treatments, whose effects alone are insufficient to prompt the reaction, possibly because adaptative changes during chronic treatment, results in a significant inhibition of lymphocyte proliferation.


    1919/2523

    Tytuł oryginału: The phenolic acids of some species of the Berberidaceae family.
    Tytuł polski: Kwasy fenolowe w niektórych gatunkach rodziny Berberidaceae.
    Autorzy: Bogucka-Kocka Anna, Sokołowska-Woźniak Anna, Krzaczek Tadeusz
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.201-208, il., tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro


    1920/2523

    Tytuł oryginału: Quantitative and structural assessment of cardiovascular drugs consumption in south-eastern Poland.
    Tytuł polski: Ilościowa ocena poziomu i struktury zużycia leków układu sercowo-naczyniowego w Polsce południowo-wschodniej.
    Autorzy: Drozd Mariola
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.209-216, il., tab., bibliogr. 3 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny


    1921/2523

    Tytuł oryginału: Pharmacoeconomics and drug utilization studies in Poland.
    Tytuł polski: Farmakoekonomika a badania zużycia leków w Polsce.
    Autorzy: Kijewska Anna
    Źródło: Ann. UMCS, Sect. DDD 2002: 15 s.217-221, bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 312,920

    Hasła klasyfikacyjne GBL:
  • ekonomika
  • farmacja

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny


    1922/2523

    Tytuł oryginału: Heart ischaemia not leading to necrosis.
    Autorzy: Nowak D[ariusz], Jeka Sl., Bożiłow Wl[Władimir]
    Źródło: Acta Med. Bulg. 2002: 29 s.14-24, bibliogr. 17 poz.
    Sygnatura GBL: 305,801

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Recognition of two phenomena of transient contractility disorders is of great importance in everyday medical practice. It associated with appreciation of the thrombolysis phenomenon as one of the possible or even necessary way in treatment of acute ischaemia of myocardium. It is also important to notice that the effects of this treatment can be visible later, even after several weeks. It seems that the most important thing is to realise that we do not have to deal with two two extermities, necrosis of myocardium and fully functional myocardium. It has to be remmbered that there exist some intermediate states with periodic, transient contractility disorders associated with very complicated changes in muscle cells. It is also important because we are more and more effective in their preventing and treatment.


    1923/2523

    Tytuł oryginału: Intraoperative identification of parathyroid glands with methylene blue in patients operated on for hyperparathyroidism.
    Tytuł polski: Chirurgiczne leczenie nadczynności przytarczyc z ich śródoperacyjną lokalizacją techniką wybarwienia błękitem metylenowym.
    Autorzy: Paszkowski Jacek, Drews Michał, Stawny Bolesław, Banasiewicz Tomasz, Hermann Jacek, Wierzbicki Tomasz, Męczyński Michał
    Źródło: Endokrynol. Pol. 2002: 53 (3) s.279-283, tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Błękit metylenowy (MB) jako barwnik tiazydowy jest związkiem o silnych właściwościach redukcyjnych, dzięki czemu znalazł zastosowanie w leczeniu zatruć substancjami methemoglobinotwórczymi. Zdolność do kumulowania przez tkanki gruczołów doktrwnych wykorzystano do wybarwienia i lokalizacji przytraczyc. W Klinice u 14 chorych zastosowano MB w celu śródoperacyjnej lokalizacji przytarczyć u chorych leczonych z powodu ich nadczynności. Po wprowadzeniu do znieczulenia i intubacji rozpoczynano wlew dożylny 1 proc. BM w roztworze 500 ml 0.9 Nacl w dawce 5 mg/kg m.c. Szybkość podawania dostosowano, tak aby został on przetoczony w ciągu 60 min. W 13 przypadkach wybarwiło się od 1 do 4 przytarczyc, natomiast w jednym przypadku nie stwierdzono zabarwienia przytarczyc. Wybarwienie przytarczyc MB jest techniką łatwą do zastosowania, nie wymagającą dodatkowego sprzętu. Nasze doświadczenia jak doniesienia z liteatury świadczą o tym, że jest to metoda bezpieczna, zarówno u chorych z prawidłową funkcją, jak i pełną niewydolnością nerek. Ani w pierwszym ani w drugim przypadku nie obserwuje się poważniejszych skutków ubocznych wynikających z podawania barwnika.

    Streszczenie angielskie: Purpose: The aim of the study was to introduce the methylene blue technique (MB) for intraoperative identification of parathyroid glands, as well as to show the accuracy of that method in patients operated on for hyperparathyroidism, on the basis of the author's experience and literature. Patients and methods. The MB technique was used in 14 patients, undergoing operations in 2001. Infusion of 500 ml of 1 p.c. MB solution in normal saline was started just after inducton of general anaesthesia and endotracheal intubation and was continued for about 60 min. The recommended dosage of MB was 5 mg/kg b.m. Results. An identification of the parathyroid glands was possible in 13 patients except one. The number of stained glands ranged from 1 to 4. Conclusions. The methylene blue technique is an easy applicable method of identification of parathyroid glands, the method being safe for patients with normal kidney function, as well as for those with renal failure. So far, no severe side effects of intravenous MB administration have been reported.


    1924/2523

    Tytuł oryginału: Investigation of the essential oil of coriander from Bulgaria.
    Tytuł polski: Badania nad olejkiem kolendry pochodzącej z Bułgarii.
    Autorzy: Stoyanova A., Konakchiev A., Berov O.
    Źródło: Herba Pol. 2002: 48 (2) s.67-70, tab., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Skład olejku z Coriandrum sativum L., uzyskanego za pomocą destylacji wodnej, destylacji ciśnieniowej i ekstrakcji heksanem, analizowano przy użyciu GC-MS. Najwyższą wydajność olejku otrzymano w trakcie ekstrakcji (1,63 proc.). Zawierał on w swoim składzie linalol (63,3 proc.), ŕ-pinen (6,1 proc.) i p-cymen (5,0 proc.). W olejkach uzyskanych na drodze destylacji wodnej i destylacji ciśnieniowej zawartość tych składników była wyższa.

    Streszczenie angielskie: The composition of the essential oils of Coriandrum sativum L., obtained by hydrodistillation, steam distillation and hexane extraction, respectively, was analyzed by GC/MS. The highest yield of oil was obtained by extraction (1.63 p.c.) and the main components were linalool (63.3. p.c.), a-pinene (6.1 p.c.) and p-cymene (5.0 p.c.). In the oils, obtained by hydrodistillation and steam distillation, the content of these components was the highest.


    1925/2523

    Tytuł oryginału: Glucosylation of p-tyrosol to salidroside by Rhodiola rosea L. cell cultures.
    Tytuł polski: Glukozylacja p-tyrozolu do salidrozydu w hodowlach komórkowych Rhodiola rosea L.
    Autorzy: Furmanowa M., Hartwich M., Alfermann A. W.
    Źródło: Herba Pol. 2002: 48 (2) s.71-75, tab., bibliogr. 27 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Na drodze biotransformacji (glukozylacji) w hodowlach komórkowych Rhodiola rosea z p-tyrozolu wytwarzano salidrozyd. Substrat był przetwarzany w 57 proc. po 72 godz. inkubacji. Obecność salidrozydu i p-tyrozolu stwierdzano przy użyciu TLC i RP-HPLC w przestrzeniach międzykomórkowych wszystkich komórek R. rosea. Zawartość salidrozydu kształtowała się w granicach 1,21 - 2,31 proc. suchej masy komórek.

    Streszczenie angielskie: Salidroside was produced using Rhodiola rosea cell cultures via biotransformation (glucosylation) of the exogenously added p-tyrosol substrate within and in vitro system. The substrate was transformed up to 57 p.c. after 72 hours of incubation. Among the biotransformation products, salidroside and tyrosol were found in intracellular spaces of all the cell treated using TLC and RP-HPLC methods. Salidroside yields of 1.21 - 2.31 p.c. dry weight were obtained.


    1926/2523

    Tytuł oryginału: The influence of elicitation on the tissue cultures of roseroot (Rhodiola rosea l.).
    Tytuł polski: Wpływ elicytacji na hodowle tkankowe różeńca (Rhodiola rosea l.).
    Autorzy: Krajewska-Patan A., Mścisz A., Kędzia B., Lutomski J.
    Źródło: Herba Pol. 2002: 48 (2) s.77-81, tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Badano wpływ elicytacji z użyciem wyciągu drożdżowego na występowanie salidrozydu w tkankach kalusowych Rhodiola rosea. Ilościowe oznaczenie zawartości salidrozydu przeprowadzono metodą kolorymetryczną. Dwie serie doświadczeń wykazały, że elicytor spowodował wzrost zawartości salidrozydu odpowiednio z 0,8 do 1,4 proc. oraz z 0,8 do 1,5 proc. Zawartość salidrozydu w elicytowanych tkankach była dwukrotnie wyższa niż w wyciągu z 5-cio letnich kłączy rośliny gruntowej. Dla określenie właściwości adaptogennych wyciągów z R. rosea wykonano dwa typy badań farmakologicznych: określenie aktywności immunostymulującej oraz działanie przeciwstresowe.

    Streszczenie angielskie: In this study the influence of the elicitation with yeast extract on the content of slidroside in the callus tissue of Rhodiola rosea was investigated. The colorimetric method for salidroside determination was used for quantitative analysis of this compound. Two series of experimetns showed that the elicitor increased the salidroside content from 0.8 p.c. to 1.4 p.c. and from 0.8 p.c. to 1.5 p.c. respectively. The salidroside content in the elicited callus was twice as high as in five-year old roots of intact plants. Two types of pharmacological studies were used for the estimation of the adaptogenic activity of R. rosea extracts: determination of immunostimulating activity and determination of antistress effect.


    1927/2523

    Tytuł oryginału: The influence of stress factors on the concentration of radionuclids in some Asteraceae and Apiaceae plants.
    Tytuł polski: Wpływ czynników stresogennych na zawartość radionuklidów w niektórych roślinach z rodziny Asteraceae i Apiaceae.
    Autorzy: Wierzchowska-Renke K., Mysłek-Laurikainen B., Głowniak K., Matul M.
    Źródło: Herba Pol. 2002: 48 (2) s.82-88, il., tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ochrona środowiska

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: W pracy prześledzono wpływ czynników stresogennych, takich jak bliskość ciągów komunikacyjnych o różnym natężeniu ruchu, nawożenie jonami tytanu oraz opanowanie przez mszyce Aphis sp. na zawartość radionuklidów w roślinach leczniczych z rodzin Asteracae i Apiaceae. Stwierdzono, że wszystkie badane rośliny zawierają radionuklidy cezu, radu i potasu. Zawartość radu, podobnie jak cezu, w większości prób była niska. Przeprowadzone analizy wykazały, że badane rośliny zawierały znaczne ilości radioaktywnego izotopu potasu. Maksymalne zawartości radionuklidów stwierdzono w próbach pozyskanych ze stanowisk zlokalizowanych przy najruchliwszych drogach. Zaobserwowano, że zastosowane nawożenie jonami tytanu wpłynęło nie tylko na wzrost i rozwój roślin lecz także na zawartość w nich radionuklidów. Odmienna była reakcja poszczególnych organów Pastinaca sativa na opanowanie tej rośliny przez mszyce. Liście roślin kontrolnych gromadziły więcej 210Pb niż liście pasternaku na których były mszyce, natomiast korzenie bogatsze były w radioaktywny potas.

    Streszczenie angielskie: The study followed the influence of stress factors - such as growth close to the road, use of fertilization with Ti ions and APhis-infestation on accumulation of radionuclids in medicinal plant species belonging to Asteraceae and Apiaceae family. The analyzed plants contained various radionuclids of caesium, radium an potassium. The contents of radium was - as in the case of caesium - low in the majority of samples. The analysis of plants also revealed important quantities of radioactive potassium isotope 40K. The plants collected from roadsides with high traffic intensity accumulate much more of thoese radionuclids. The fertilization the Ti ions of mentioned plants influenced not only the height and the developement, but resulted in changes of radionuclids content as well. Leaves, fruits and roots of Pastinaca sativa reacted differently to pest treatments. Control plants leaves accumulated more 210Pb than Aphis-infested ones. The roots of control plants were richest in 40K.


    1928/2523

    Tytuł oryginału: Porównanie metod oznaczania miana ziela konwalii majowej (Convallaria maialis l.) zawartych w Farmakopei Polskiej IV i Deutsches Arzneibuch 10.
    Tytuł angielski: The comparison of the biological assay of Convallaria maialis l. glycosides using methods according to Pharmacopoea Polonica IV and Deutsches Arzneibuch 10.
    Autorzy: Szeląg A., Magdalan J., Burycz T., Rutkowska M., Pieśniewska M.
    Źródło: Herba Pol. 2002: 48 (2) s.89-93, tab., bibliogr. 5 poz., sum.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Ze względu na dużą liczbę związków farmakologicznie czynnych oraz różnice w ich zawartości zależne od strefy klimatycznej, konieczne jest biologiczne mainowanie surowców roślinnych zawierających glikozydy nasercowe. W Polsce do oznaczania miana glikozydów kardenolidowych konwalii stosuje się miareczkowanie wykonywane na gołębiach, zaś w Unii Europejskiej badania te przeprowadza się na świnkach morskich. Przystąpienie Polski do Unii będzie wiązało się z konecznoscią zmiany procedur mianowania glikozydów nasercowych. Celem badań było porównanie wyników oznaczenia miana glikozydów zawartych w partii ziela konwalii majowej metodami opisanymi w FP IV (na gołębiach) oraz DAB 10 (na świnkach morskich). Porównując wyniki badań przeprowadzonych na gołębiach i na świnakch morskich nie stwierdzono istotnych różnic w mianie równoważności względem wzorca konwalatoksyny (W), co wskazuje, że obie metody cechuje podobna czułość. Metoda zawarta w FP IV jest prostsza i nie wymaga specjalistycznego oprzyrządowania.

    Streszczenie angielskie: Herbal raw materials contain large numbers of pharmacologically active compounds with concentrations dependant on climatic zone therefore biological methods ar estill the preffered ones in their standardization. In Poland pigeons are used for Convallaria glycosides standardization whilst in European Union countires - guinea-pigs. Once Poland has joined European Union, the procedures of biological assay of glycoside preparations will have to be changed. This study aimed to compare the results of biological assay of glycosides contained in the lot of Convallaria maialis herb using methods according to FP IV (on pigeons) and DAB 10 (on guine-a-pigs). No major differences between teh results of the experiments carried out on pigeons and guinea-pigs were identified during the study which indicateds that both methods show similar sensitivity. The methods according to FP IV is simpler and does not require speicalist equipment.


    1929/2523

    Tytuł oryginału: Lipophilic constituents of the twigs of Staphylea holocarpa hemsl.
    Tytuł polski: Lipofilne składniki gałązek Staphylea holocarpa hemsl.
    Autorzy: Masterov… I., Woldemichael G. M., Tóth J., Ubik K.
    Źródło: Herba Pol. 2002: 48 (2) s.94-97, tab., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 303,599

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie polskie: Badania lipofilnych składników występujących w gałązkach Staphylea holocarpa Hemsl. Wykazały obecność: n-nonakozanu, á-sitosterolu i dwóch triterpenów - kwasu betulinowego i kwasu á-ursolowego.

    Streszczenie angielskie: A study of the lipophilic constitutents of the twigs of Staphylea holocarpa Hemsl. revealed the presence of n-nonacosane, á-sitosterol and two triterpenes: betulinic and á-ursolic acids.


    1930/2523

    Tytuł oryginału: Characterization of optical properties of some photosensitizers in solution and in tissue-like media. Experiment and Monte Carlo simulation.
    Autorzy: Matuszak Z., Wasilewska-Radwańska M., Skwara A., Rogoda E.
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.135-142, il., bibliogr. 9 poz.
    Sygnatura GBL: 306,499

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the present paper absorption spectra of some classical photosensiterizers such as methylene blue, eosin, fluorescein, hematoporphyrin were measured and simulated using the Monte Carlo method. The days were investigated in a water solution and in the tissue-like medium Intralipid, which is a standarized aqueous fat emulsion with well-defined optical parameters. The results of experiments were used in the Monte Carlo simulations of the light transport in media containing the investigated photosensistizers. The true absorption spectra were calculated from the spectra blurred by scattering. The results of simulation confirmed the possibility of determination within the scattering media, both the kind of the dye and its quantity. This fact is very important in the use of absorption spectroscopy to determine the content of dyes in real biological tissues.


    1931/2523

    Tytuł oryginału: Dosimetry of X-ray beams in stereotactic radiosurgery.
    Autorzy: Rostkowska J., Kania M., Bulski W., Wysocka A.
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.143-156, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The accuracy of the dosimetry of narrow phaton beams is very important for precise stereotactic radiosurgery. At the Centre of Oncology in Warsw the stereotactic radiosurgery treatments are performed with the moving beam multi-arc technique using narrow circular collimators of various sizes. In this study, the results of measurements of depth doses, beam profiles and beam outputs with small ionization chambers, diamond detectors and films are presented along with the evaluation of the adequacy of dosimetric systems most suited for such measurements.


    1932/2523

    Tytuł oryginału: Changes in the electrical conductivity of the ç-irradiated BAT collagen.
    Autorzy: Kubisz Leszek, Marzec Ewa, Jaroszyk Feliks
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.157-164, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: Measurements of dc electrical conductivity were performed on the air-dried BAT collagen, within a temperature range of 290-500 K. The temperature elevation of the sample led to an increase in electrical conductivity. The signa-T relationship reflects the following: the structure of the material, the thermal history of the sample and interactions with ionising radiation. The changes in dc electrical conductively generated during linear heating were analysed to determine the processes occurring in the material. The activation energy of the charge conduction process was calculated on the basis of the Arrhenius plots for electrical conductivity. In comparison with non-irradiated samples, the dose of 50 kGy led to higher electrical conductivity up to 440 K. For the dose of 500 kGy, for all temperatures, a distinct increase in electrical conductivity was observed. At temperatures below the flex point, i.e. 415 K and 460 K for 50 and 500 kGy respectively, the activation energy was dose-independent. At temperatures higher than the flex point, irradiation decreased the activation energy. For higher temperatures, the activation energy increased with the dose.


    1933/2523

    Tytuł oryginału: Evaluation of the size of local bone injuries by means of ultrasound.
    Autorzy: Dekhtyar Yuri, Derjugina Inna, Katashev Alexei, Katasheva Julija, Ozolanta Iveta, Tatarinov Alexei
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.165-171, il., bibliogr. 8 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • in vitro

    Streszczenie angielskie: The present work estimates the use of ultrasound to determine the size of local injuries in the rabbit lower jaw. The injuries were modelled in vitro by a various number of splits of the various depth, made on the lower edge of the jaw by dental split-dusc. Ultrasonic immaging and evaluation of effective velocity of ultrasound propagation across the injury was made to estimate the size of the injury. Measurements were performed on the phantom, made from bone, covered with soft tissue. Measurements of the effective velocity were made for uncovered bone, as well. Propagation velocity decreased when the total injury volume increased, both in the open bone, and the bone, covered with soft tissue, in the latter case the variation of propagation velocity being smaller. This fact may be used to evaluate the injury size in vivo.


    1934/2523

    Tytuł oryginału: X-ray Fluorescence analysis of human brain tissue and body fluids.
    Autorzy: Boruchowska M., Lankosz M., Adamek D., Ostachowicz B., Ostachowicz J., Tomik B.
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.173-181, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The suitability of the Energy Dispersive X-ray Fluorescence (EDXRF) technique to determine of the elemental composition of human brain tissue samples and body fluids was investigated. The XRF was used in the study of pellet samples of white and grey matter of brains. A quantitative analysis of the specimens was performed using a method of fundamental parameters. The Total Refluction-X-ray Fluorescence (TXRF) method was applied to determine trace elements in the whole blood, blood serum and the cerebrospinal fluid. Two methods of sample preparation, i.e. without any sample preparation and that with digestion of sample with nitric acid were applied with respect to detection limits. For both methods gallium was used as an internal standard.


    1935/2523

    Tytuł oryginału: Properties of camptothecin analogues - promising topoisomerase I inhibitors determined by fluorescence spectoscopy methods.
    Autorzy: Kruszewski Stefan, Burke Thomas G.
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.183-192, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 306,499

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Camptothecin (CPT) and related congeners have become an important class of S-phase anticancer agents. Unfortunately CPT hydrolyses under physiological conditions, and converts into inactive carboxylase form. The hydrolysis problem with campthothecin and many analogues is exacerbated in the human blood. The principal goal of these researches was to find camptothecin analogues that display omproved blood stability. One of new camptothecis DB-67 exhibits impressive blood stability. Fluorescence spectroscopy methods were used to determine the physical and to predict the biological properties of camptothecins.


    1936/2523

    Tytuł oryginału: Simple telemetry system for ECG recording.
    Autorzy: Pietraszek Stanisław, Chwiedoruk Sebastian
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (3) s.193-198, il., bibliogr. 5 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca techniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This work presents a simple telemetry system that provides possibility of local heart rate monitoring and transmission of ECG signals to a PC computer via an infrared data link within the distance of few meters. The proposed telemetry system consists of a patient unit (ECG amplifier, A/D converter, infrared transmitter), and a PC unit (infrared receiver, serial RS232 link and software). Amplifield ECG signal is sampled 250 times per second, and a 10-bit A/D conversion is performed by a microcontroller PIC16F877, the main part of the microcontroller program is connected to a QRS detector. Digital filters are matched to an average QRS during sinus rhythm from a well known pass-band filter with a center frequency of 16.7 Hz and Q factor of 4.7. The heart rate (HR) is computed as an average of 4 from 7 last detected R-R intervals, where two shortest and one longest interval are rejected. The above alghoritms provide high quality recording of ECG signal during rest and exercise.


    1937/2523

    Tytuł oryginału: Symposium on ethical, legal and economic aspects of transplantation, Warsaw, September 26-29th, 2002.
    Tytuł polski: [Sympozjum na temat etycznych, społecznych, prawnych i ekonomicznych aspektów przeszczepiania narządów, Warszawa, 26-29 września 2002].
    Źródło: Ann. Transplant. 2002: 7 (4) s.5-22, il., tab., bibliogr. [przy artyk.] - Sympozjum nt. etycznych, społecznych, prawnych i ekonomicznych aspektów przeszczepiania narządów Warszawa 26-29.09. 2002
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • prawo
  • ekonomika
  • transplantologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • sprawozdanie
  • streszczenie
  • tytuł obcojęzyczny


    1938/2523

    Tytuł oryginału: Ethical and societal problems in organ transplantation.
    Autorzy: Rowiński Wojciech, Wałaszewski Janusz
    Źródło: Ann. Transplant. 2002: 7 (4) s.7-9 - Sympozjum nt. etycznych, społecznych, prawnych i ekonomicznych aspektów przeszczepiania narządów Warszawa 26-29.09. 2002
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • prawo
  • ekonomika
  • transplantologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Transplantation medicine, like on other medical speciality, is connected with a wide range of very difficult ethical issues. Among those are: availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of treatment. Authors discuss sensitive aspects in societal perception of the Polish Transplantation Act, ethical issues of living donor kidney transplantation, the role of mass media and economic aspects of transplantation.


    1939/2523

    Tytuł oryginału: The induction of active or peripheral tolerance in organ transplantation: dream or reality.
    Autorzy: Petranyi Gyozo G.
    Źródło: Ann. Transplant. 2002: 7 (4) s.16-22, il., tab., bibliogr. 38 poz. - Sympozjum nt. etycznych, społecznych, prawnych i ekonomicznych aspektów przeszczepiania narządów Warszawa 26-29.09. 2002
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • genetyka
  • immunologia
  • transplantologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Immunological tolerance induction is one of the most exciting research fields in experimental and clinical transplanation. From the first discovery of Nobel Prize awarded to L. Brent and P. Medawar, beside the classical induction of central tolerance in newborn mice, several methods, interventions and compounds have been introduced with a view to establishing tolerance. It was clarified that the mechanisms have different characteristics for central and peripheral or active/operative transplantation tolerance. In the case of the latter, tolerance was accompanied with mixed chimeric state. In the last decade, new compounds, such as monoclonal antibodies specific for membrane receptors on T- and APC cells responsible for signal I and signal 2 functions have been employed to induce operative tolerance. Among various methods and immunosuppressive interventions, non-myeloblative treatments combined with hematopoietic stem cell infusion showed the most effective results. This form of induction is associated with the well known "beneficial transfusion effect" in kidney transplantation. Based on the experimental achievements of clinical organ transplantation, various protocols have been introduced to induce peripheral tolerance. In spite of the short observation time of this progress the results seem to be promising, first of all, in the prolonged rejection-free survival time of the graft and the possibility to withdraw the immunosuppressive treatment altogether.


    1940/2523

    Tytuł oryginału: Invited editorial.
    Autorzy: Olszewski Waldemar L.
    Źródło: Ann. Transplant. 2002: 7 (4) s.24
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • transplantologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • informator
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1941/2523

    Tytuł oryginału: Differentiation of cellular reaction to alloantigens and bacterial infection in human skin graft - immunosuppressive drugs or antibiotics.
    Autorzy: Mościcka-Wesołowska M., Olszewski W. L., Zolich D., Stelmach E.
    Źródło: Ann. Transplant. 2002: 7 (4) s.25-27, il., tab., bibliogr. 5 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • transplantologia
  • dermatologia i wenerologia
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The human hand transplantations prompted revival of interest in evaluation of the rejection process of the grafted skin and its control with the antirejection drugs [1-3]. In case of first hand transplantation a combined immunsuppressive regimen was applied with currently available drugs resulting in acceptance of the entire composite graft. No major untoward systemic effects of antirejection therapy were observed. The most important clinical conclusion was the allogenic skincan be accepted and function as in a normal extremity, altough the attack of host cells on the graft can not be totally eliminated. Chronic perivascular and subepidermal infiltrates with recipient cells could be seen [4]. Another problem connected with skin transplantion is graft infection. Skin is inhabited by a specific spectrum of bacteria [5]. Allografted skin is more sensitive to bacterial penetration that normal skin due to local damage by the host-versus-graft cellular reaction and comprised immune reactivity to bacterial antigens by the immunosuppressive therapy. The histological pictures of rejecting skin represent a mixture of cellular reaction against the graft and penetrating microbes. Alloreaction requires modification of immunosuppressive regimen and infection is an indication for prolonged antibiotic therapy against skin bacteria flora. The question arises how to discriminate the alloreactive and bacterial changes in the skin graft. We studied the histological pictures of rejecting and infected human skin after transplantation to scid mice.


    1942/2523

    Tytuł oryginału: The response of the lymphatic system to the human skin resident bacteria.
    Autorzy: Cakała M., Olszewski W. L.
    Źródło: Ann. Transplant. 2002: 7 (4) s.30-35, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • transplantologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: We designed a study to identify skin bacterial strains producing most intensive changes in lymphoid tissue of the draining nodes and analyse the node cell phenotypes reacting to bacterial antigens. The obtained results were expected to help in establishing rational therapy in recipients of hand allografts. The highest level of activation of lymphoid tissue was found after inoculation with S. epidermidis, Acinetobacter, Enterobacter and Aerococcus. There was an increase in weight and cell concentration of nodes, intense expression of W3/25 + (CD4), OX6+ (class II), EDI + (CD14), CD54 + OX62 + cells in the paracortex and medulla 7 days after bacterial inoculation. The most advanced changes were seen after recall bacterial stimulation. Taken together, evident differences in the intensity of response to the investigated bacterial strains were found. The obtained information can be useful for establishing rational antibiotic therapy after composite graft transplantation.


    1943/2523

    Tytuł oryginału: Formation of synapses between dendritic cells and lymphocytes in skin lymph in an allogeneic reaction.
    Autorzy: Mijal J., Galkowska H., Olszewski W. L.
    Źródło: Ann. Transplant. 2002: 7 (4) s.36-41, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • hematologia
  • transplantologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • psy

    Streszczenie angielskie: Skin is an important component of a composite tissue allograft an is considered among the most immunogenic of tissues. Because of the skin's high degree of immunogeneicity, until recently it was widely assumed that the dosage of immunosuppressive drugs required to prevent rejection was to high to be used safely in the clinical setting. The mechanism of resistance of skin allografts to pharmacological immunosuppression remains unknown. We investigated this problem at the level of antigen presentation by graft dendritic cells to recipient lymphocytes. Cells obtained from lymph draining skin were used and formation of synapses, necessary for antigen presentation, in the presentation, in the presence of CsA or FK506 was studied. The study provided the following information: a) increased frequency of allogeneic compared to syngeneic DC-L synapses in culture, b) increased expression of CD49d on lymph allogeneic DC and L and of HLA DR on L forming synapses, c) lack of a downregulating effect of CsA on the allogeneic DC-L synapse formation rate, d) decreased formation rate autologous and allogeneic DC-L synapses and lower expression of CD49d and HLA DR of cells treated with FK506. The suppressive effect of FK506 on DC-L synpases formation may explain the mechanism of effectiveness of this drug on skin allograft survival.


    1944/2523

    Tytuł oryginału: Interaction of E. coli with dendritic cells - a model for studies of graft infections.
    Autorzy: Stanisławska J., Interewicz B., Szyper E., Olszewski W. L.
    Źródło: Ann. Transplant. 2002: 7 (4) s.42-45, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • transplantologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: The rejection process of skin allografts is mediated by dendritic cells (DC) and lymphocytes. The recipients DCs are engaged not only into an allogenic but also antibacterial reaction to the penetrating bacteria. The capacity of these cells to sample sites of pathogen entry, respond to microbial signals and activate naive T cells suggests a critical role for CD in intiating antimicrobial immunity. In our study, we investigated the ability of the green fluorescent protein (Gfp) labelled E. coli to infect DC. We studied kinetics of in vitro and in vivo adherence and incorporation of E. coli by rat spleen and bone marrow (BM) DC. Bacterial adherence to the cell surface was observed after 24 h incubation of DC with bacteria. A 24-hour culture of DC from both sources was followed by bacterial adherence to all cells and egulfment by at least 50 p.c. of cells. There was an increased expression of the phenotypic markers on the DC cultured with E. coli. The Gfp-labelled E. coli should be useful for studies of the activation of dendritic cells. The method will allow to study the process of simultaneous activation of DC by allo- and bacterial antigens.


    1945/2523

    Tytuł oryginału: Polyclonal antibodies induction therapy in kidney transplantation: a single center experience.
    Autorzy: Malaise J., Meyer M. De, Mourad M., Squifflet J. P.
    Źródło: Ann. Transplant. 2002: 7 (4) s.46-48, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1946/2523

    Tytuł oryginału: Factors influencing low incidence of living donors for renal transplantation in Poland.
    Autorzy: Sieńko J., Ostrowski M., Ciechanowski K., Kamiński M., Sulikowski T., Pabisiak K., Paczkowski M., Domański L., Fronczyk A., Ślozowski P., Tejchman K.
    Źródło: Ann. Transplant. 2002: 7 (4) s.49-51, il., bibliogr. 14 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Purpose of the study: To answer the question: "Why are only 3.8 p.c. of kidney transplantations in Poland from living donors?" Material and methods: To research was conducted using data from anonymous polls addressed to family members of dialyzed patients (potential donors). Results: Almost everybody (98 p.c.) had heard about the possiblity of treating renal insufficiency by kidney transplantation, but only 77 p.c. knew about the possibility of giving their own kidney to a related person. Merely 36 p.c. had been informed about this treatment method by a doctor. The most common fears within respondents were those of: health worsening after donating a kidney - 45 p.c., and the operation itself (taking an organ) - 39 p.c.


    1947/2523

    Tytuł oryginału: Hyperacute rejection of living related kidney graft caused by IgG endothelial specific antibodies with a negative monocyte cross-match.
    Autorzy: Grandtnerova Barbara, Laca L'udovit, Jahnova Eva, Horvathova Miroslava, Balaz Vladimir, Hovoricova Blanka, Hudec Peter, Zarnovicanova Maria
    Źródło: Ann. Transplant. 2002: 7 (4) s.52-54, bibliogr. 27 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: We present a case report of a 30-year-old man, who hyperacutely rejected a blood group identical. HLA-haploidentical living related kidney graft in spite of the fact that he had never been immunized. Anti-endothelial IgG antibodies that did not react with monocytes were detected with flow cytometry, on a panel of human umbilical cord cells in his serum retrospectively. On the basis of this exeperience we put for consideration the possibility of regular examination of non-HLA antibodies in potential living graft recipients.


    1948/2523

    Tytuł oryginału: Organ procurements in West Pomerania in years 2000-2001.
    Autorzy: Ostrowski M., Bohatyrewicz R., Ciechanowski K., Pabisiak K., Sieńko J., Myślak M., Kamiński M., Sulikowski T.
    Źródło: Ann. Transplant. 2002: 7 (4) s.55-57, il., bibliogr. 3 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • transplantologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Year by year the actual number of transplanted organs has been growing in Poland. In the event of the Województwo Zachodniopomorskie (Western Pomeranian Province) the primary activities were focused on informing medical personnel at hospital departments about approaching donors through trainings for such medical personnel. Such activities resulted in both acceptance and support, especially by medical personnel of medium as well as lower ranks. Since 1983 two transplant units have been functioning in the Province: SPSK-2 and S. P. W. S. Z. in Szczecin, and since 2000 two co-ordination offices, too. Main result of our activities can be seen in the number of organs procured for transplantation. In 2000 we had 27.7 procurements per million (ppm), in 2001 there were 39.9 ppm.


    1949/2523

    Tytuł oryginału: Osteogenic properties of various HeLa cell lines and the BMP family genes expression.
    Autorzy: Kochanowska I. E., Włodarski K., Wojtowicz A., Niemira K., Ostrowski K.
    Źródło: Ann. Transplant. 2002: 7 (4) s.58-62, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Heterotopic ossicles were included in thigh muscles of immunosuppressed mice by implantation of suspension of several HeLa cell lines. These ossicles are the object of our research on osteoporosis. It was found that various HeLa cell lines differ in their potential to induce osteogenesis. In the previous paper we demonstrated the involvemen of bone morphogenetic proteins (BMP-4 and BMP-6) secreted by HeLa cells in this phenomenon. In the present paper we try to find out the reason of the heterogeneity of various cell lines regarding the differences in their osteoinductive potencies. By the use of semiquantitative RT-PCR the differences in mRNA expression for several isoforms of BMP proteins in examined HeLa cell lines were found. The presence or absence of some of the BMP isoforms seems to be correlated with the quantity of heterotopically induced mineralised tissues. This was measured by weighting the deposited mineral after digestion of soft tissues surrounding the induced ossicles. This finding is supporting the thesis on high and uncontrolled heterogeneity of various HeLa cell lines used all over the world.


    1950/2523

    Tytuł oryginału: Mental state of subjects diagnosed 15 years earlier (in childhood and/or adolescence) with depressive disorders.
    Autorzy: Rabe-Jabłońska Jolanta
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.25-34, tab., bibliogr. 56 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • pediatria
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to assess the current mental status of subjects, who in childhood or adolescence were diagnosed with a depressive disorder. In adulthood, various mental disorders occurred in more than 1/2 of the subjects, especially mood disorders: recurrent major depression, dysthymia, biopolar affective disorder (in about 1/3 of subjects) and alcohol or other psychoactive substance abuse or dependence (in about 1/4 of subjects), with and without depressive disorders. Complex diagnosis: depressive disorders and personality disorders or depressive disorders and alcohol or psychoactive substance abuse or dependence, or depressive disorders and anxiety disorders, was made in about 1/6th of subjects. Adult mood disorders were noted in patients who in the past had various depressive disorders. In childhood, before occurrence of the first episode of depressive disorders, some of those patients had anxiety disorders, conduct disorders, specific learning disorders and/or ADHD.


    1951/2523

    Tytuł oryginału: Psychosomatic aspects of Alzheimer's disease.
    Autorzy: Richarz Bernhard
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.35-48, bibliogr. 56 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: This case study pertains to the little regard often given to scientific observations concerning the psychosomatic aspects of Alzheimer's disease. It presents clinical investigations, based on the treatment of three patients hospitalised in a psychoanalytically oriented facility. The psychodynamics and group dynamics involved in the treatment program are described in detail. Of the three patients featured in the article, the unconscious personality structures are specifically identified. Reference is also made to the possible psychosomatic aspects of the disease. Psychodynamic findings are commensurate with the neurobiology of the disease and contribute to the understanding of how personal factors and neurodegenerative changes might be linked. The paper concludes with a discussion on the findings and implications for future research.


    1952/2523

    Tytuł oryginału: Therapy by means of creative self expression.
    Autorzy: Burno Mark Ye.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.49-53, bibliogr. 2 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The name of my psychoterapeutic method is therapy by means of creative self expression [1, 2]. This method has proved particulary effective in cases of Personality (characterological) Neurotic, Borderline and Schizotypical, Schizophrenic Disorders - with a painful feeling of one's own inferiority.


    1953/2523

    Tytuł oryginału: Efficacy of psychiatric day hospital treatment: review of research findings and design of a European multi-centre study.
    Autorzy: Kallert T[homas] W., Schtzwohl M., Kiejna A., Nawka P., Priebe S., Raboch J.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.55-71, tab., bibliogr. 75 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The paper presents a literature review of research findings on acute treatment in psychiatric day hospitals, and outlines the desing of an ongoing multi-site study on the effectiveness of acute day hospital treatment. The review is based on relevant older publications and recent randomised controlled trials comparing day hospital treatment with inpatient care. The findings suggest that (a) a wide range of patient groups are cared for in day hospitals, (b) both patients and their relatives assess day hospital treatment favourably, (c) treatment in day hospitals is at least as effective as inpatient care, and (d) day hospital treatment may lead to significant cost savings as compared to in-patient care. There are, however, a number of important questions that cannot be answered on the basis of the existing literature, and further research on the topic is warranted. The EDEN-study (European Day Hospital EvaluatioN) is a randomised controlled trial comparing day hospital treatment with conventional in-patient care and following the same protocol in five European countries (Czech Republic, Germany, Poland, Slovakia and United Kingdom). Aims and methods of the study are presented.


    1954/2523

    Tytuł oryginału: Some aspects of arsenic toxicity and carcinogenicity in living organism with special regard to its influence on cardiovascular system, blood and bone marrow.
    Autorzy: Szymańska-Chabowska Anna, Antonowicz-Juchniewicz Jolanta, Andrzejak Ryszard
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.101-116, bibliogr. 118 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • toksykologia
  • ochrona środowiska
  • hematologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: This paper gathers data on the most current aspects of arsenic action, especially its influence on the cardiovascular system, blood and bone marrow. A potential carcinogenic mechanism of arsenic is also discussed. Arsenic is a potent toxicant that may exist in several valencies and in a number of inorganic and organic forms. Most cases of arsenic-induced toxicity in humans are due to exposure to inorganic arsenic, and there is an extensive database on the human health effects of common arsenic oxides and oxyacids. Exposure of humans living near hazardous waste sites may involve inhalation of arsenic dusts in the air, ingestion of arsenic in water, food or soil, or dermal contact with contaminated soil or water. The exposure to arsenic via the inhalation route is responsible for the increased risk of lung cancer, although respiratory irritation, nausea and skin effects may also occur. The oral route of exposure to arsenic predominates in the general population. The most common effects of arsenic ingestion are gastrointestinal irritation, peripheral neuropathy, vascular lesions, anemia, skin diseases, including skin cancer and other cancers of the interanal organs like bladder, kidney, liver or lung. Relatively little information is available on the effects of direct dermal contact with inorganic arsenicals, but several studies indicate local irritation and dermatitis as the major ones.


    1955/2523

    Tytuł oryginału: The ICOH Conference Contributions.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.117-197, il., tab., bibliogr. [przy ref.] - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie


    1956/2523

    Tytuł oryginału: From risk-based health surveillance to health promotion: an evidence-based experience in a health care setting.
    Autorzy: Franco Giuliano, Cella Maria T., Tuccillo Elvira, Ferrari Francesco, Minisci Emanuele, Fusetti Leonardo
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.117-120, il., tab., bibliogr. 9 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In the European countries the health surveillance may be provided as a part of the national health system intervention. In Italy, the legislative Decree (626/94) makes the health surveillance compulsory for all those workers who are exposed to occupational risks. The aim of this study was to describe the introduction of preventive and protective measures, according to the new regulations, in the teaching hospital of the University of Modena. The population examined in 2000 included 1523 workers. Specific health surveillance protocols were prepared on the grounds of the risk characteristics based on the scientific evidence and on the risk perception. The intervention was oriented towards health promotion. The subjects were classified into 10 groups according to the risk characteristics. The percentage of workers ranged from 4 p.c. to 42 p.c., depending on the exposure-related health changes. Moreover, the study explored some of the health surveillance benefits: an improvement in worker's satisfaction, an improvement in relationship between stakeholders, an early detection of health changes and a sickness absence reduction after the influenza vaccination program.


    1957/2523

    Tytuł oryginału: Policy requirements and performance indicators for good practice in workplace health: public health perspectives.
    Autorzy: Barański Bogusław
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.121-132, bibliogr. 37 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The author lists the main objectives, work areas and benefits of good practice in health, environment and social management in enterprises (GP HESME). History of this cross-sectoral and multidisciplinary approach to management of occupational, lifestyle, environmental and social health determinants is outlined. Health policy requirements and performance indicators are provided to facilitate GP HESME implementation at the enterprise and local levels. The role of local authorities and networking of enterprises, representing various sectors is highlighted.


    1958/2523

    Tytuł oryginału: Setting national targets to improve occupational health.
    Autorzy: Snashall David
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.133-137, tab., bibliogr. 7 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This paper describes a national strategy to improve occupational health and a longitudinal view of a 15 year project undertaken in the UK, logging the key developments. The first results should become apparent in 2005. Progress will be reported.


    1959/2523

    Tytuł oryginału: Networking between occupational health services, client enterprises and other experts: difficulties, supporting factors and benefits.
    Autorzy: Peltom„ki P„ivi, Husman Kaj
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.139-145, tab., bibliogr. 43 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This study explores difficulties, supporting factors and benefits of networking to studied enterprises and other network partners (focus on OHS and client enterprises). The study also explores social capital as a resource produced in network relations, and trust as a core dimension of social capital, and trust as a binding element in networking. The study is a mixed methods research (both qualitative and quantitative research materials). The most important supporting factors were: committed and active focus person, teamwork skills, long relationships, familiarity, trust and two-way communication in co-operation, shared goals, norms and values, an equal cost and benefit ration, and the high quality of services. The biggest problems were the lack of skills to operate in the network and difficulties in maintaining the network, weak communication, lack of confidence, inconvenient size or composition of the network, overlapping information, cliques, nodes and missing links. The benefits were versatile: knowledge and skills accumulate, the network multiplies resources, fluency of co-operation, innovations, commitment and trust increase, good practices expand, and moreover, the quality, many-sidedness and appropriateness of operations improve. Networking is beneficial but demanding. There are many limitations. Networks are not equal for every network partner (inequality in cost and benefit ratio). Networks produce social capital for participants. Successful networking requires trust relations between network partners.


    1960/2523

    Tytuł oryginału: How is "coverage" defined for occupational health services?
    Autorzy: Muto Takashi, Mizoue Tetsuya, Araki Yoko, Miyazaki Shogo, Marui Eiji
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.147-154, tab., bibliogr. 31 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The proportion of workers receiving occupational health services (OHS), or OHS coverage, is considered an important indicator in the evaluation of the national OHS levels. Although the term "coverage" is used in some papers, the definition of the term appears to vary from author to author. Despite vague definitions of the term, the issue has not been much studied. It appears that this vagueness has not led to attempts to establish a clear definition of the term. This study was undertaken to clarify the meaning of "coverage" when used in relation to OHS. Papers using "coverage" as an indicator of the OHS levels or discussing the issue were collected and analyzed. The first aspect examined concerned the definition of "coverage." Next, the denominator (the target population), and methods for estimating the numerator (the number of workers provided with OHS) were described according to this definition. Few papers dealing with OHS coverage provided an explicit definition; none of the papers stated clearly the OHS functions encompassed when considering coverage, using simply the term in the context. Nor was the worker category to be represented in the denominator discussed, e.g. employees only, or the entire working population. The method for estimating the numerator was generally undefined. This study makes it clear that the term "coverage" in relation to OHS is currently used without clear definition. To permit objective assessments of the national OHS levels, "coverage" must be defined in terms of three elements: OHS functions, the numerator and the denominator of the proportion representing the extent of OHS coverage.


    1961/2523

    Tytuł oryginału: Occupational health care system and its effectiveness in Lithuania.
    Autorzy: Januskevicius Vidmantas, Telksniene Ruta
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.155-158, il., bibliogr. [2] poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The Ministry of Labor and Social Affairs in collaboration with the Ministry of Health Care carries out the activities aimed at solving occupational health and safety problems in Lithuania. Occupational health care system in Lithuania consists of three levels: 1) primary occupational health centers in the industry; 2) general practitioners taking care of employees' health; and 3) the State Labor Inspectorate. The second level includes regional occupational medicine centers that are located in the three major cities of Lithuania: Vilnius, Kaunas and Klaipeda. Hygiene investigations of workplaces and prophylaxis of occupational diseases are performed by regional Public Health Center Departments of Occupational Medicine. The third level is provided by the Lithuanian Center of Occupational Medicine in Vilnius and the State Commission of medical and Social Examination. The complicated cases of occupational diseases are treated in specialized departments of the University clinics. The real situation of work safety is not good. About 600 cases of occuaptional diseases and over 2500 accidents, including 60 fatal causalities are registered annually.


    1962/2523

    Tytuł oryginału: Trends and development of occupational health services in Norway.
    Autorzy: Lie Arve
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.159-163, bibliogr. 8 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Occupational Health Services (OHS) in Norway cover approximately 1.2 million employees, equivalent to 60 p.c. of the total work force. THey employ nurses (800), physicians (500), physiotherapists (360), safety engineers (400), psychologists (30) and others (400), a total of 2500 full time employmancy. The average cost of the OHS amounts to 150 euros per employee, a total cost of 180 million euros per year. In 1998, the OHS in Norway were evaluated. The evaluation, initiated by the ministry, revealed that although 80 p.c. of the enterprises are fairly satisfied with their OHS, there is still much to be improved, in particular quality development and customer focus. By 2000 the National Practics Guidelines. ("Good OHS") were developed as a joint effort of the professional OHS associations, representatives from the social partners and the NIOH. These guidelines have been evaluated and well accepted by the OHS. Last year the Ministry of Labour appointed an advisory group of experts on OHS. The group was asked to examine: the "branch provision" on obligatory OHS and the availability of health resources; the legislation on OHS tasks; the quality improvement of OHS; and the OHS in small enterprises. The report was ready in May 2001 stating that the OHS may be a useful contributor to the improvement of the health, environment and safety in enterprises and included the following recommendations: to establish the OHS for all within 10 years and to ratify relevant ILO convention; to develop a certification system for the OHS; to ensure financial public support of the OHS for the small enterprises; and to expand the OH hospital departments as important supportive agents for the OHS. The report will be a background document for the revision process of the Work Environment Act to be soon put into force.


    1963/2523

    Tytuł oryginału: Quality assessment in occupational health services: a review.
    Autorzy: Michalak Jacek
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.165-171, tab., bibliogr. 32 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Various understanding of occupational health services (OHS) roles, structures and functions in European countries depends mainly on the legal, financial and organizational issues, which influence the health of employees. The OHS aims and functions are often related to public health, and/or to the managment of enterprises. In consequence, quality assessment (QA) of OHS is used in the management of enterprises and the implementation of health policy. The study was performed to delineate the methods and techniques used in OHS QA and to find the most useful ones, which might be applied in Polish occupational health services. The web pages, current literature, and international reports on OHS were reviewed. The OHS tasks, activities and methods for OHS QA are different in diferent European countries. Numerous voluntary methods are believed to be more effective, but their effectiveness is not as yet unequivocally proven. Quality assessment methods in POlish OHS are more similar tothose used in clinical medicine. Good Practice in Health Environment and Safety Management in Enterprises (GP HESME) offers a new insight into in OHS QA.


    1964/2523

    Tytuł oryginału: Certification and quality assurance in dutch occupational health services.
    Autorzy: Marcelissen Frans H. G., Weel Andr‚ N. H.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.173-177, il., bibliogr. 1 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Since 1994, each Dutch enterprise has to be affiliated to an independent occupational health service (OHS), recognized by the government. In addition, each enterprise has to be supported by this occupational health service in its activities for the improvement of working conditions, and in the guidance of employees absent from work. From 1994 to 1998, the government was carrying out the certification and recognition of occupational health services. Since 1998 the certification has been carried out by private certifying institutions, in general consultancy bureaus that also provide ISO certification. In the Netherlands, the supervision of the quality of occupational safety and health care is tworfold. Firstly, the Labor Inspectorate is checking if the enterprises keep to the rules. For example, each enterprise should have a risk assessment report at its disposal. The latter should be approved by the OHS. If an enterprise does not meet these rules, a penalty may be imposed. In practice, this happens rather seldom. Secondly, each OHS unit should be recognized by the Ministry of Social Affairs and Employment. The recognition takes place if the private certifying institution has assessed that the OHS meet a large number of requirements laid down in the "Guideline for the Certification of Occupational Health Services". This Guideline consists of 50 conditions and about 200 verification points. The requirements deal with the internal organization and the output. By order of the Dutch government the IVA, a Dutch institute for social research, has recently investigated if this certification leads to a sufficient guarantee for appropriate occupational safety and health care...


    1965/2523

    Tytuł oryginału: Towards an effective co-operation between companies and occupational safety and health services.
    Autorzy: Drift Dorine Willy van der
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.179-183, bibliogr. 4 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • medycyna pracy

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In the Dutch Working Conditions Act, every employer is required to organize preventive occupational safety and health services (OSH-Services). The OSH-Services need to have a certification that can be compared with ISO-9000. This article is focused on the question: How can companies and OSH-Services co-operate more effectively to obtain a better OSH management system inside the companies? To answer this question, TNO has developed an approach to support organisations in the health care branch to obtain a better service from their OSH-Service. TNO has chosen to focus on supporting the companies, because of the recognition that the effectiveness of OSH-Services has been found in effects on their customers, the companies. As a result of the research project a stepwise approach with several tools was developed. After the development phase, parts of the approach and the tools were used in several other consultancy projects. Evaluative studies have not been performed yet. However, from the development activities and several consultancy projects some remarkable evaluative findings can be given. The approach can be useful for companies and OSH-Services to make their goals and expectations more explicit. The approach also helps to make the management of companies clear that their own behavoiur is relevant to the achievement of their goals in occupational health and safety policy, in addition to the services provided by the OSH-Service and their professionals. The approach cannot fulfil the possible need for qualification of OSH professionals. However, the approach can make the OSH professionals clear in what way they have qualification needs.


    1966/2523

    Tytuł oryginału: Developing a model for occupational health provision in primary care.
    Autorzy: Harrison John, Harrison Catherine E.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.185-192, il., tab., bibliogr. 6 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia
  • medycyna pracy

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This is a report of a survey commissioned by Newcastle and North Tyne Health Authority. The aim of the project was to assess the occuaptional health needs of both GPs and their staff working in the General Practice in Newcastle and North Tyneside. The aim of the survey has been to obtain information about occupational health needs from general practitioners and their practice managers. The survey design has been a cross-sectional study using questionnaires and practice visits. The information obtained from the practice managers was validated by visits to selected practices. The visists also facilitated a qualitative assessment of occupational health arrangements, training needs and issues that might be important in determining an appropriate model for a primary care-based occupational health service. The results of the needs analysis have shown both general support for an occuaptional health service and priority areas for such a service. The challenge will be to develop a service that delivers targeted occupational health in a way that is acceptable to all members of staff working in general practice. The service should be seen as a developing service, initially focused to provide a dual role. There will be a core occupaitonal health service for all staff, including GPs, and a specialist service designed to meet the specific identified needs. There will be an opportunity to include the service in an overarching occupational health service within the Tyne and Wear area.


    1967/2523

    Tytuł oryginału: Health and safety economics: limitations of economic appraisal of occupational health services activities in Poland.
    Autorzy: Rydlewska-Liszkowska Izabela
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (2) s.193-197, bibliogr. 10 poz. - Międzynarodowa konferencja nt. stanu zdrowia pracowników Łódź 09. 2001
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • ekonomika

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Methods of economic appraisal developed for evaluating activities in health care system may as well be successfully used for evaluating occupational health service activities. This involves the problem of resources management and cost containment not only at the company level, but also at different managerial and institutional levles. The decision makers have to know what resources are spent on occupational health, what is the effectiveness and efficiency of investing in employees health. The key issue of good understanding of the theory and practice of economic appraisal is a precise definition of costs, effectiveness and benefits. Another important area is the identification of information sources and barriers of economic appraisal. The results of the project carried out by the Nofer Institute of Occuaptional Medicine have provided evidence that defining costs, effectiveness and benefits of preventive activities need to be developed. It becomes even more clear after an analysis of existing limitations of economic appraisal in Polish enterprises.


    1968/2523

    Tytuł oryginału: Langerhans cell histiocytosis in a patient with systemic lupus erythematosus: a clonal disease responding to treatment with cladribine, and cyclophosphamide.
    Autorzy: Robak Tadeusz, Kordek Radzisław, Robak Ewa, Bartkowiak Jacek, Biernat Wojciech, Liberski Paweł, Błoński Jerzy
    Źródło: Leuk. Lymphoma 2002: 43 (10) s.2041-2046, il., bibliogr. 27 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • immunologia
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Langerhans cell histiocytosis (LCH) is a rare neoplastic disease of specific dentritic cells which belong to the monocyte-macrophage system. The association of LCH with autoimmune disease is extremely rare and to our knowledge its coexistence with systemic lupus erythematous (SLE) has not been described so far. We report a case of LCH affecting liver, spleen and abdomen lymph nodes, which developed in an adult female six years after diagnosis of SLE treated for a long time with prednisone. Histology showed infiltration of characteristic Langerhans cells with folded, grooved or lobulated nuclei with fine chromatin. In the background there were eosinophils, lymphocytes and CD-68-positive histiocytes. The neoplastic cells were S100p-immunopositive, but stained negatively for CD1a-probably as the result of overfixation of consulted material. CD-68 was present mostly in macrophages. Ultrastructurally, the tumour cells presented structures consistent with Birbeck granules. Clonal origin of neoplastic cells was shown using the HUMARA-PCR assay. The disease was refractory to treatment with high doses of prednisone and vincristine but complete response was achieved after treatment with caldribine combined with cyclophosphamide.


    1969/2523

    Tytuł oryginału: Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia.
    Autorzy: Styczyński Jan, Wysocki Mariusz, Dębski Robert, Juraszewska Edyta, Malinowska Iwona, Stańczak Elżbieta, Ploszyńska Anna, Stefaniak Jolanta, Mazur Benigna, Szczepański Tomasz
    Źródło: Leuk. Lymphoma 2002: 43 (9) s.1843-1848, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • pediatria
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • badanie porównawcze
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Therapy results in childhood acute myelogenous leukemia (AML) differ from those of acute lymphoblastic leukemia (ALL). Cellular drug resistance might be one of the reasons of therapy failure in AML. The aim of the study was the analysis of ex vivo drug resistance profile in childhood initial and relapsed AML in comparison to initial ALL. Fifty-three AML samples were tested for chemosensitivity and results were compared with those of 106 initial ALL samples. Ex vivo drug resistance was tested by means of the MTT assay. Up to 29 cytotoxic drugs were tested for each patient. When compared to de novo ALL samples, myeloblasts from initial AML samples were significantly more resistant to most tested drugs, except cytarabine, mercaptopurine and thioguanine. Relapsed AML samples, in relation to initial AML samples, showed comparable sensitivity to cytarabine, idarubicin, fludarabine and cladribine. Patients, who have died due to refractory or relapsing disease, were already on first diagnosis 2-fold more resistant to cytarabine, 6.4-fold more resistant to cisplatin and 3-fold more resistant to carboplatin, when compared to those who stay in remission. Resistance to prednisolone was observed in 85 p.c. initial and all relapsed AML samples, in comparison to 33 p.c. of ALL samples. Resistance to cytarabine occurred in 2.1 p.c. of ALL and 12 p.c. of AML cases while a patient with Down syndrome presented the most sensitive drug resistance profile. In conclusion this study shows that no drug was found which, on average, was more effective in AML than in ALL samples. The sensitivity of myeloblasts to platinum derivatives might have prognostic value.


    1970/2523

    Tytuł oryginału: Radiotherapy monitoring by means of 1H MR spectroscopy - in vitro and in vivo studies.
    Autorzy: Sokół Maria, Maniakowski Zbigniew, Kupka Teobald, Jarosz Ewa, Sokół Radosław
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.207-217, il., bibliogr. 17 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: The effects of irradiation on concentrations and relaxation behaviour of brain metabolites was studied by means of high-resolution 1H NMR in vitro. The model studies were performed on rat brains irradiation with the doses of 20 Gy applied in fractions. Standard procedures were used to obtain HCIO4 extracts of rat brains. The 1H NMR studies of the extracts solutions in D20 were performed using a Varian Inova-300 NMR spectrometr. The integral intensities of metabolite signals were found to change during the irradiation cycle and after it. These changes are accompanied by the variations in the T1 relaxation times. The results of the in vivo study were compared with those of 1H MR in vivo on the early response to treatment of the irradiated human brain tissue.


    1971/2523

    Tytuł oryginału: The effect of ç-irradiation on the dielectric behaviour of animal tissues.
    Autorzy: Marzec Ewa, Kubisz Leszek, Jaroszyk Feliks
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.219-224, il., bibliogr. 7 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • bydło
  • in vitro

    Streszczenie angielskie: Dielectric spectroscopy has been applied to the study of the relaxation mechanisms of bone and keratin in the electric field frequency range of 10**1-10**5 Hz and at temperatures from 22 to 200řC. In this paper, particular attention has been paid to the effects of temperature and ionising radiation on the dielectric properties of these biological materials.


    1972/2523

    Tytuł oryginału: An artificial signal source for evoked potentials data recording systems.
    Autorzy: Pietraszek Stanisław, Łatkowski Jacek
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.225-230, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,499

    Typ dokumentu:
  • praca techniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The quality of recorded Brain Stem Auditory Evoked Responses (BAERS) greatly depends on many factors such as potential characteristic, skin preparation, and level of background noise. That is why three is a need of a stable source of a BAERS signal with a priori known signal to noise ratio (SNR). The paper describes an acoustical triggered signal source of Brain Stem Auditory Evoked Potentials, called an EP generator that imitates the real investigation with the patient. The main concept to similar to the arbitrary waveform generator where signal is playedback from memory. The heart of the EP generator is trigerred D/A converter that after click produces, one of ten patterns stored in the data memory. Noise may be added to pattern signal with a defined SNR in the range of 8 to 60 dB. Application of the proposed EP generator is similar to the examination of the patient and can significantly improve testing the quality of BAERS data recording systems.


    1973/2523

    Tytuł oryginału: Evaluation of physical parameters of a CT unit in radiotherapy treatment planning.
    Autorzy: Skrzyński Witold, Tołwiński Jerzy, Bulski Wojciech
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.231-238, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of this study was to evaluate physical parametes of a Siemens Somaton DRH computed tomography unit used for radiotherapy treatment planing. Three groups of measurements were performed: control of the image geometry, dose absorbed by the patients, and estimation of the function relating CT numbers to tissue electron density. It was found that for properly performed examination, doses absorbed by patients do not exceed reference dose values published in the European Commision guideliness. Additional reference levels could be established for non-diagnostic examinations performed only before radiotherapy treatment planing (breast tomography). Function relating CT numbers to issue electron density determined for the Siemens Somatom DRH does not differ significantly from that used in the Cadplan treatment planing system in the soft tissue range. Beam hardening artefacts and changes in image slice width are the main causes of variations in CT numbers. Inaccuracies of dose distribution calculations due to the observed inaccuuracies were also estimated.


    1974/2523

    Tytuł oryginału: Measurements of radon gas concentration in some selected kindergartens in the region of Bydgoszcz.
    Autorzy: Pyskir Małgorzata, Gutsze Aleksander, Kapałka Beata A.
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.239-244, il., tab., bibliogr. 7 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • ochrona środowiska
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: It is nowadays estimated that about half of the radiation exposure in natural environment results from breathing radon and its daughter products. The measurements of radon concentration in buildings have become a center of interest in recent years. In this paper, the results of measurements of radon concentration in selected kindergartens in the region of Bydgoszcz are presented. TASTRAK detectors with CR-39 were exposed in 38 kindergartens in December 2000 and in 15 kindergartens in April 2001 for a period of 432 hours. The measured radon gas concentrations ranged from 10 Bq/m3 to 378 Bq/m3.


    1975/2523

    Tytuł oryginału: Glucose monitor reader for visually impaired diabetics patients.
    Autorzy: Pietraszek Tadeusz
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.245-249, il., tab., bibliogr. 4 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • okulistyka
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca techniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This paper describes the project in which visually impaired diabetics can operate a blood glucose monitor. This can be done with the help of a device reading aloud all messages (including glucose levels), displayed on a LCD screen. The reader contains a microprocessor, a EPROM memory, a D/A converter and a loudspeaker with an amplifier. Most of the messages are recorded as a whole, and is played directly from the memory, while the rest are synthesised - spelled letter by letter. All the numeric values are red correctly up to 999. At present the device connects to OneTuch and reads Polish messages. Thanks to the software, the process of creating/updating a memory image is quick and easy. Very little work is required to change it to other languages. The product is adapted to OneTouh glucose monitor, which was chosen as the best device for this purpose. In the future, by co-operting with manufacturers, other reader interfaces can be developed.


    1976/2523

    Tytuł oryginału: Selected educational aspects in medical physics related to the implementation of the EC-Directive 97/43/EURATOM.
    Autorzy: Wasilewska-Radwańska Marta
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (4) s.251-256, tab., bibliogr. 5 poz.
    Sygnatura GBL: 306,499

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of this paper was to outline the needs to establish appropriate curricula that should be recognosed in the implementation procedure in Poland of the EC-Directive 97/43/Euratom of 30 June 1997 on health protection of individuals against dangers of ionising radiation in relation to medical exposure. This Directive shall apply to thev following medical exposure: the exposure of patients as part of their own medical diagnosis or treatment, the exposure of individuals as part of occupational health surveillance, the exposure of individuals as part of health screening programmes, the exposure of healthly individuals or patients voluntarily participating in medical or biomedical, diagnostic or therapeutic, research programmes, the exposure of individuals as part of medico-legal procedures as well as to the exposure of individuals knowingly and willingly helping (other than as part of their occupation) in the support and comfort of individuals udergoing medical exposure. (Article 1 (2) and (3)).


    1977/2523

    Tytuł oryginału: Daunorubicin, cytarabine and 2-CdA (DAC-7) for remission induction in "de novo" adult acute myeloid leukaemia patients. Evaluation of safety, tolerance and antileukemic activity.
    Tytuł polski: Daunorubicyna, cytarabina i 2-CdA (DAC-7) w leczeniu indukującym remisję u chorych na ostrą białaczkę szpikową "de novo". Ocena bezpieczeństwa, tolerancji i aktywności przeciwbiałaczkowej.
    Autorzy: Hołowiecki Jerzy, Robak Tadeusz, Kyrcz-Krzemień Sławomira, Grosicki Sebastian, Wrzesień-Kuś Agata, Hellmann Andrzej, Skotnicki Aleksander, Jędrzejczak Wiesław, Konopka Lech, Zdziarska Barbara
    Źródło: Acta Haematol. Pol. 2002: 33 (2) s.239-247, tab., bibliogr. 19 poz., sum.
    Sygnatura GBL: 305,450

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: 2-Chlorodenoksyadenozyna (2-CdA, cladeybina, Biodribin) jest analogiem nukleozydów purynowych aktywnym w leczeniu nowotworów układu krwiotwórczego i chłonnego. Na początku lat dziewięćdziesiątych wykazano synergiczną interakcję inhibitorów reduktazy rybonukleotydowej (fludarabiny i 2-CdA) i cytarabiny (Ara-C), w wyniku której wzrasta stężenie Ara-CTP w mieloblastach. Na podstawie tych obserwacji Polska Grupa Ostrych Białaczek (PALG) rozpoczęła pilotowe badania, których celem była ocena skojarzonego leczenia cytarabiną daunorubicyną i kladrybiną (DAC-7) jako pierwszej linii chemioterapii indukującej remisję u chorych na ostrą białaczkę szpikową (AML). Do badań zakwalifikowano 50 chorych na AML w wieku 18-59 lat (mediana 45 lat), 28 kobiet i 22 mężczyzn, u których chorobę rozpoznano w latach 1999-2000. U 36 chorych (72 proc.) uzyskano całkowitą remisję (CR). U wszystkich wystąpiła granulocytopenia i małopłytkowość IV stopnia wg klasyfikacji WHO. U 38 chorych w okresie neutropernii wystąpiła infekcja III lub IV stopnia. Objawy niepożądane ze strony wątroby, nerek lub serca obserwowano rzadko. Dziewięciu chorych (18 proc.) zmarło w okresie polekowej neuropenii. U 5 chorych opornych na leczenie DAC-7 zastosowano alternatywną chemioterapię II linii. Uzyskane wyniki uzasadniły rozpoczęcie wieloośrodkowych, randomizowanych badań porównujących DAC-7 ze standardową chemioterapią danorubicyną i cytarabiną (3x7).

    Streszczenie angielskie: 2-chloro-2-deoxyadenosine (2-CdA, cladribine. Biodribin) is a purine analogue effective in lymhoid and haematopoietic malignancies. In 1992-93 synergistic interaction of ribonucleotide reductase inhibitors (fladarabine, 2-CdA) and cytarabine (Ara-C) increasing Ara-CTP concentration in myeloblasts was proved. Based on these findings the Polish Acute Leukaemia Group (PALG) started a pilot study on administration of cytarabine, daunorubicin and cladrybine (DAC-7) as the first-line induction treatment of adult acute myeloid leukaemia (AML) patients. Fifty adult AML patients, aged 18-59 (median 45), 28 women, 22 men diagnosed in 1999-2000 were included into the study. Thirt six patients (72 p.c.) achieved complete remission (CR). All of them developed thrombocytophenia and agranulocytosis (WHO grade IV). The latter was associated with grade III or IV infection rate of 38 p.c. Liver, kidney or cardiac side-effects were rarely observed. No patients (18 p.c. died in the course of postherapeutic pancytopenia. In 5 patients with refractory disease alternative second-line treatment was administered. Those results encouraged us to design an original, randomized, multicenter trial comparing DAC-7 with the standard daunorubicin + cytarabine (3+7) induction programme. This project is currently under way.


    1978/2523

    Tytuł oryginału: The state of Monte Carlo calculations in radiation treatment planning.
    Autorzy: Rosenow Ulf F.
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (3) s.93-100, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny


    1979/2523

    Tytuł oryginału: The impact of the time factor on the outcome of a combined treatment of patients with laryngeal cancer.
    Autorzy: Milecki Piotr, Stryczyńska Grażyna, Kruk-Zagajewska Aleksandra
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (3) s.101-108, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • onkologia
  • otorynolaryngologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Purpose: To investigate the impact of the time factor on the locoregional control in combined treatment (surgery and postoperative radiotherapy) in patients with advanced laryngeal cancer. Materials and metods: Between January 1993 and December 1996, 254 patients with pT3 or pT4 and pNO - PN2 laryngeal cancer were treated by surgery and postoperative radiotherapy (RT). The median age of patients was 56.3 years (range: 30 - 70 years). The analyzed group consisted of 236 males (92 p.c.) and 18 females (8 p.c.). In all cases total laryngectomy was performed. 196 out of 254 patients underwent homolateral neck dissection and 58 out of 254 bilateral neck dissection. RT began 45 days postoperatively (range: 22 to 78 days) and continued for 47 days (range: 40 - 74 days). The primary tumour bed was irradiated to the median total dose of 61.2 Gy (range: 57 - 64 Gy) and all regional lymph nodes were treated in all patients to a dose of 50 Gy. Postoperative RT was indicated in case of close postoperative margins at the tumour site or pathological status of lymph nodes described as pN1 or pN2. Univariate and multivariate analyses were used to determine the predictors for locoregional failure. The following factors were studied for their prognostic importance of locoregional outcome: the overall treatment time (OTT), radiotherapy treatment time (RTT), the interval between surgery and the beginning of radiotherapy, age, sex, pT and pN categories. Results: The actuarial 5-year overall survival rate was 49 p.c., the actuarial loco regional control rate was 70 p.c. The univariate analysis, using a log-rank...


    1980/2523

    Tytuł oryginału: High dose rate endobronchial brachytherapy in the management of advanced lung cancer - comparison of different doses - preliminary assessment.
    Autorzy: Skowronek Janusz, Adamska Krystyna, Zwierzchowski Grzegorz, Piotrowski Tomasz, Cofta Szczepan, Świerkocki Krzysztof, Piorunek Tomasz, Młynarczyk Witold
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (3) s.109-115, il., tab., bibliogr. 21 poz. - Konferencja pt. Postępy w radioterapii - diagnoza, planowanie leczenia, rokowanie Poznań 19-21.04. 2001
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Purpose: Brachytherapy is one of the most efficient methods of overcoming endobronchial obstruction in palliative treatment of lung cancer. In single cases, brachytherapy is performed as radical treatment, however in most of cases, due to advanced clinical stage it has a paliative aim. In the absence of clear consensus regarding the value of doses used in brachytherapy different fraction doses are used in clinical treatment. The aim of this work is to compare results of palliative high dose rate brachtherapy using various treatment protocols with the view to analysing differences in survival and diminishing breathing difficulties. Material and methods: Between May 1999 and February 2000 at the Greatpoland Cancer Center, 69 patients with advanced lung cancer were treated by high dose rate brachytherapy. They were disqualified from radical treatment due to advanced clinical stage. The age of the patients ranged from 39 to 76 years (average 53.2 years). Fofty-one patients received a total dose of 22.5 Gy in 3 fractions once a week, 18 patients received one single fraction of 10 Gy. All the patients were divided into two groups according to their clinical stage and the Karnofsky score - those with the Karnofsky score lower than 50 were qualified for a single fraction treatment. They were under clinical and endobronchial observation as regards survival rates, local remission and subsiding dyspnoea, breathing, cough and haemoptysis in the first, third, sixth and twelveth month of observation. Results: Four weeks after the end of treatment subjective improvement (subsidence of all symptoms)...


    1981/2523

    Tytuł oryginału: Allogeneic bone marrow transplantation in children with acute lymphoblastic leukaemia in the first and second complete remission conditioned with fractionated total body irradiation and cyclophosphamide or etoposide.
    Autorzy: Wachowiak Jacek, Malicki Julian, Buczkowski Dariusz, Stryczyńska Grażyna, Kosicka Grażyna, Leda Michał, Pieczonka Anna
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (3) s.117-125, il., bibliogr. 39 poz. - Konferencja pt. Postępy w radioterapii - diagnoza, planowanie leczenia, rokowanie Poznań 19-21.04. 2001
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Patients and methods: From 1993 to 2001 thirty-two children underwent bone marrow transplantation (BMT) for acute lymphoblastic leukaemia (ALL) (12 in I complete remission /I CR/ of high-risk /HR/ ALL, and 20 in II CR after early bone marrow or combined bone marrow/organ relapse). Except for two syngeneic all others were matched sibling donor transplants. All patients (pts) were conditioned with fractionated total body irradiation (FTBI) at a total dose of 12.6 Gy, given in 8 fractions during 4 days with lung shielding (9.4 Gy) and cyclophosphamide (CY) 60 mg/kg i.v for 2 days (total dose 120 mg/kg) (n = 1 in I CR and n = 11 in II CR) or etoposide (VP) to mg/kg i.v (n = 11 in I CR and n = 9 in II CR). Patients in I CR were given 1.1 - 4.9 x 10**8 nucleated cells/kg (med. 2.7 x 10**8/kg), while pts in II CR 1,9-4,0x10**8 nucleated cells/kg (med. 2,7x10**8/kg. For graft versus host disease (GvHD) prevention cyclosporin A (CsA) 3 mg/kg/d i.v was administered alone in 22 pts (n = 9 in I CR and n = 13 in II CR) or in combination with "short" methotrexate +/- prednisone in 8 pts (n = 3 in I CR and n = 5 in II CR). Two pts transplanted with syngeneic BM received no GvHD prevention. The regimen related toxicity (RRT) was graded according to the system developed by Bearman et al. (1988). Results: Only mild or moderate expression of RRT was observed (Gl toxicity Iř - 80 p.c., IIř - 4 p.c.; stomatitis Iř - 40 p.c., IIř - 20 p.c.; hepatic toxicity Iř - 28 p.c.; renal, bladder and cardiac toxicity Iř - 4 p.c.) and no transplant related deaths occurred (TRM = 0 p.c.)....


    1982/2523

    Tytuł oryginału: Non-tumoral non-infectious intracranial calcifications.
    Tytuł polski: Nieguzowe zwapnienia śródczaszkowe pochodzenia niezakaźnego.
    Autorzy: Różyło-Kalinowska Ingrid, Złomaniec Janusz, Jędrzejewski Grzegorz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.1-8, il., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1983/2523

    Tytuł oryginału: Prevalence of infections of the Salmonella strains in the Lublin voivodship and in Poland in the years 1980-2000.
    Tytuł polski: Zatrucia pokarmowe w województwie lubelskim w latach 1980-2000 w porównaniu z ich występowaniem w populacji ogólnopolskiej.
    Autorzy: Kalinowski Paweł
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.9-20, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1984/2523

    Tytuł oryginału: Angiotensin-converting enzyme gene insertion/deletion polymorphism in Polish patients with myocardial infarction.
    Tytuł polski: Polimorfizm insercyjno-delecyjny genu enzymu konwertującego w polskiej populacji pacjentów z zawałem serca.
    Autorzy: Sobstyl Jacek, Dzida Grzegorz, Puźniak Andrzej, Mosiewicz Jerzy, Hanzlik Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.21-28, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • genetyka

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    1985/2523

    Tytuł oryginału: Dynamic computed tomography assessment of local extent and resectability of esophageal carcinoma.
    Tytuł polski: Dynamiczna tomografia komputerowa w ocenie miejscowej rozległości i resekcyjności raka przełyku.
    Autorzy: Czekajska-Chehab Elżbieta, Smajkiewicz Ludwik, Drop Andrzej
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.29-38, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 45-64 r.ż.


    1986/2523

    Tytuł oryginału: Dynamic CT of hepatic cirrhosis.
    Tytuł polski: Dynamiczna tomografia komputerowa w marskości wątroby.
    Autorzy: Drop Andrzej, Rosińska-Bogusiewicz Katarzyna, Zbańska-Klonowska Katarzyna, Czekajska-Chehab Elżbieta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.39-46, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 45-64 r.ż.


    1987/2523

    Tytuł oryginału: Effect of nursing care on self-care efficiency of patients with hemiparesis.
    Tytuł polski: Wpływ opieki pielęgniarskiej na wydolność w zakresie samoobsługi pacjentów z niedowładem połowiczym.
    Autorzy: Adamczyk Kazimiera, Lorencowicz Regina, Zajko Anna, Rejszel Elżbieta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.47-52, bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia
  • pielęgniarstwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1988/2523

    Tytuł oryginału: Personality features of children treated due to vocal nodules.
    Tytuł polski: Cechy osobowości dzieci leczonych z powodu guzków głosowych.
    Autorzy: Niedzielski Antoni, Niedzielska Grażyna, Gwizda Grażyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.53-57, il., tab., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia
  • pediatria
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska


    1989/2523

    Tytuł oryginału: TEOAE after treatment of otitis media with effusion.
    Tytuł polski: Otoemisja akustyczna (TEOAE) po leczeniu efuzją wysiękowego zapalenia ucha środkowego.
    Autorzy: Niedzielska Grażyna, Kątska Emilia
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.58-61, il., bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska


    1990/2523

    Tytuł oryginału: Plasma activity of Interleukin-6 and some acute phase proteins in severe drug-induced skin adverse reactions.
    Tytuł polski: Aktywność osoczowa Interleukiny-6 i niektórych białek ostrej fazy w ciężkich reakcjach polekowych.
    Autorzy: Czelej Dorota, Chodorowska Grażyna, Lecewicz-Toruń Barbara
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.62-67, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia
  • immunologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1991/2523

    Tytuł oryginału: The frequency of different plural renal arteries rare variants.
    Tytuł polski: Rzadkie warianty występowania mnogich tętnic nerkowych.
    Autorzy: Vilhova Irena, Kryvko Yurij Yarosławovicz, Maciejewski Ryszard
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.68-73, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1992/2523

    Tytuł oryginału: Shift of zinc in serum and tissues in course of experimental acute pancreatitis.
    Tytuł polski: Przesunięcia tkankowe cynku z surowicy w przebiegu doświadczalnego ostrego zapalenia trzustki.
    Autorzy: Bojarski Krzysztof, Dąbrowski Andrzej, Wallner Grzegorz, Maciejewski Ryszard
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.74-78, tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    1993/2523

    Tytuł oryginału: Odontogenic keratocyst in Gorlin-Goltz syndrome.
    Tytuł polski: Torbiel naskórkowa w zespole Gorlina-Goltza.
    Autorzy: Różyło-Kalinowska Ingrid, Różyło T. Katarzyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.79-85, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • stomatologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1994/2523

    Tytuł oryginału: Styles of coping with stress among patients with allergic disease.
    Tytuł polski: Style radzenia sobie ze stresem wśród pacjentów ze schorzeniami alergicznymi.
    Autorzy: Latalski Maciej, Makara-Studzińska Marta, Gajewska Marzena, Rudnicka-Drożak Ewa
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.86-91, bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1995/2523

    Tytuł oryginału: The analysis of the structure of suicidal behaviours in the region of the Lublin voivodship in the years 1997-1999.
    Tytuł polski: Analiza struktury zachowań samobójczych w rejonie województwa lubelskiego w latach 1997-1999.
    Autorzy: Rudnicka-Drożak Ewa, Skórzyńska Hanna, Makara-Studzińska Marta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.92-96, bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    1996/2523

    Tytuł oryginału: Social support for patients with allergic diseases.
    Tytuł polski: Wsparcie społeczne dla pacjentów ze schorzeniami alergicznymi.
    Autorzy: Latalski Maciej, Makara-Studzińska Marta, Gajewska Marzena, Rudnicka-Drożak Ewa
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.97-103, bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1997/2523

    Tytuł oryginału: The behaviours of the inhabitans of the Lublin region in the situations of sudden cardiac arrest as reflected in the opinions of the Ambulance Service doctors.
    Tytuł polski: Zachowania mieszkańców Lubelszczyzny w sytuacji nagłego zatrzymania krążenia w opiniach lekarzy Pogotowia Ratunkowego.
    Autorzy: Mikuła Agnieszka, Goniewicz Mariusz, Latalski Maciej, Chemperek Ewa
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.104-111, il., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    1998/2523

    Tytuł oryginału: The usefulness of computed tomography spatial imaging in diagnosing lung tumours.
    Tytuł polski: Przydatność obrazowania przestrzennego tomografii komputerowej w diagnostyce guzów płuc.
    Autorzy: Krupski Witold, Złomaniec Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.112-118, il., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    1999/2523

    Tytuł oryginału: Antimicrobial therapy of upper respiratory tract infections in children.
    Tytuł polski: Antybiotykoterapia w zakażeniach dróg oddechowych u dzieci.
    Autorzy: Tokarz Agnieszka, Kozioł-Montweka Maria, Rutyna Rafał, Chudnicka Alina, Sidor-Wójtowicz Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.119-126, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • farmacja
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska


    2000/2523

    Tytuł oryginału: Labyrinthitis in chronic otitis media.
    Tytuł polski: Zapalenie błędnika w przebiegu przewlekłego zapalenia ucha środkowego.
    Autorzy: Siwiec Henryk, Klatka Janusz, Szymański Marcin, Trojanowski Piotr
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.127-130, il., bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2001/2523

    Tytuł oryginału: The application of ultrasound contrast, 3D imaging and tissue harmonic imaging in the differential diagnosis of lymph nodes enlargement in children.
    Tytuł polski: Zastosowanie ultrasonograficznych środków kontrastujących, obrazowania 3D oraz THI w diagnostyce różnicowej powiększonych węzłów chłonnych u dzieci.
    Autorzy: Dybiec Ewa, Brodzisz Agnieszka, Piętka Magdalena, Obłoza Małgorzata, Niedzielska Grażyna, Kowlczyk Jerzy, Wieczorek Paweł
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.131-142, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • hematologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2002/2523

    Tytuł oryginału: Taste perception of cigarette smokers.
    Tytuł polski: Percepcja smakowa u palaczy tytoniu.
    Autorzy: Gromysz-Kałkowska Kazimiera, Wójcik Kazimiera, Szubartowska Ewa, Unkiewicz-Winiarczyk Aneta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.143-154, il., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    2003/2523

    Tytuł oryginału: Concentration of mineral requirements in bone marrow tissue of patients with lymphoma malignum.
    Tytuł polski: Stężenie pierwiastków śladowych w szpiku kostnym u chorych na szpiczaka mnogiego.
    Autorzy: Grzybowska Ludmiła, Floriańczyk Bolesław, Stryjecka-Zimmer Marta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.155-159, tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2004/2523

    Tytuł oryginału: The influence of oxidative stress on the level of malondialdehyde (MDA) in different areas of the rabbit brain.
    Tytuł polski: Wpływ stresu oksydacyjnego na poziom dialdehydu malonowego (MDA) w różnych częściach mózgu królika.
    Autorzy: Kowalczuk Krystyna, Stryjecka-Zimmer Marta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.160-164, tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki


    2005/2523

    Tytuł oryginału: The eye lens evaluatuion of the atorvastatin-treated white rat.
    Tytuł polski: Wpływ atorwastatyny na zmiany w soczewce oka szczura.
    Autorzy: Zakrzewski Paweł, Milewska Jolanta, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.165-171, il., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • okulistyka

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    2006/2523

    Tytuł oryginału: The epidermis mitochondria ultrastructure evaluation of the etretinate-treated white rat.
    Tytuł polski: Zmiany ultrastrukturalne mitochondriów naskórka szczura białego poddanego działaniu etretinatu.
    Autorzy: Budzyńska Beata, Budzyński Arkadiusz, Jędrych Barbara, Milewska Jolanta, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.172-177, il., bibliogr. 3 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury


    2007/2523

    Tytuł oryginału: Information needs of the patients undergoing bone marrow transplantation.
    Tytuł polski: Zapotrzebowanie na wsparcie informacyjne wśród pacjentów leczonych metodą przeszczepu szpiku kostnego.
    Autorzy: Krasuska Małgorzata E., Dmoszyńska Anna, Daniluk Jadwiga, Stanisławek Andrzej
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.178-185, bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • hematologia
  • psychiatria i psychologia
  • onkologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2008/2523

    Tytuł oryginału: Palliative care - transiting old tradition and values into the modern health care paractice.
    Tytuł polski: Opieka paliatywna. Przeniesienie tradycji i starych wartości do nowoczesnej opieki.
    Autorzy: Krasuska Małgorzata E., Stanisławek Andrzej, Mazurkiewicz Maria, Daniluk Jadwiga
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.186-193, il., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2009/2523

    Tytuł oryginału: Quality of care. Understanding the theoretical framework and learning the practical setting.
    Tytuł polski: Jakość opieki. Założenia teoretyczne i ich realizacja.
    Autorzy: Krasuska Małgorzata E., Stanisławek Andrzej, Kurylcio Lucjan, Daniluk Jadwiga
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.194-200, il., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2010/2523

    Tytuł oryginału: Serum zinc (Zn) level dynamics in blood serum of patients with acute viral hepatitis B and early recovery period.
    Tytuł polski: Dynamika stężenia cynku (Zn) w surowicy krwi chorych w ostrym okresie wirusowego zapalenia wątroby typu B oraz we wczesnej rekonwalescencji.
    Autorzy: Fota-Markowska Hanna, Przybyła Anna, Borowicz Irena, Modrzewska Roma
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.201-209, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2011/2523

    Tytuł oryginału: Prolactin concentration in the serum of male patients with chronic hepatitis C.
    Tytuł polski: Stężenie prolaktyny w surowicy krwi mężczyzn chorych na przewlekłe wirusowe zapalenie wątroby typu C.
    Autorzy: Kiciak Sławomir, Fota-Markowska Hanna, Borowicz Irena, Modrzewska Roma, Przybyła Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.210-216, tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • choroby zakaźne
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska


    2012/2523

    Tytuł oryginału: Fertility following laparoscopic uterine myomectomy in an infertile patient treated for 10 years. Case report.
    Tytuł polski: Przywrócenie płodności drogą laparoskopowego usunięcia licznych mięśniaków macicy u pacjentki po 10-letnim leczeniu niepłodności. Opis przypadku klinicznego.
    Autorzy: Jakiel Grzegorz, Sobstyl Małgorzata, Wójtowicz Magdalena
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.217-221, bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska


    2013/2523

    Tytuł oryginału: Histological examination of the extrabulbar segment of the optic nerve in experimental animals after administration of Cladribine.
    Tytuł polski: Histologiczna ocena odcinka pozagałkowego nerwu wzrokowego po zastosowaniu leku immunosupresyjnego - Kladrybiny u zwierząt doświadczalnych.
    Autorzy: Kwietniewska Małgorzata, Stelmasiak Zbigniew, Sekita-Krzak Joanna, Visconti Józef, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.222-226, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • króliki


    2014/2523

    Tytuł oryginału: Influence of the new medicine - 2-CDA (Cladribine) on the ultrastructure of the extrabullar segment of the optic nerve in rabbits of New Zeland breed.
    Tytuł polski: Wpływ nowego leku immunosupresyjnego - 2-CDA (Kladrybina) na ultrastrukturę odcinka pozagałkowego nerwu wzrokowego królików rasy nowozelandzkiej..
    Autorzy: Kwietniewska Małgorzata, Stelmasiak Zbigniew, Sekita-Krzak Joanna, Visconti Józef, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.227-232, il., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • króliki


    2015/2523

    Tytuł oryginału: Protective effects of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: ultrastructural studies.
    Tytuł polski: Działanie ochronne ACTH (4-9) w degeneracji komórek nerwowych hipokampa wywołanej deksometazonem: badania ultrastrukturalne.
    Autorzy: Sekita-Krzak Joanna, Czerny Krystyna, Żebrowska-Łupina Iwona, Stępniewska Maria, Visconti Józef, Wieczorski Marcin
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.233-238, 2 s. tabl., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy


    2016/2523

    Tytuł oryginału: Immunocytochemical examinations of hippocampal nerve cells after experimental administration of dexamethasone.
    Tytuł polski: Badania immunocytochemiczne komórek nerwowych hipokampa po doświadczalnym podaniu deksametazonu.
    Autorzy: Sekita-Krzak Joanna, Czerny Krystyna, Żebrowska-Łupina Iwona, Stępniewska Maria, Visconti Józef, Pedrycz-Wieczorska Agnieszka
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.239-244, il., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy


    2017/2523

    Tytuł oryginału: Neuroprotective effects of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: morphological studies.
    Tytuł polski: Neuroprotekcyjne działanie ACTH (4-9) w degeneracji komórek nerwowych hipokampa wywołanej deksametazonem: badania morfologiczne.
    Autorzy: Sekita-Krzak Joanna, Czerny Krystyna, Żebrowska-Łupina Iwona, Stępniewska Maria, Visconti Józef, Koziej Jacek
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.245-253, il., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy


    2018/2523

    Tytuł oryginału: The influence of nitroglycerin on myocardial 99mTc-Tetrofosfmin uptake defects in coronary artery disease.
    Tytuł polski: Wpływ nitrogliceryny na regionalne zaburzenia wychwytu 99mTc-Tetrofosminy w chorobie niedokrwiennej serca.
    Autorzy: Tarkowska Anna, Cholewiński Witold, Widomska-Czekajska Teresa, Stefaniak Bogusław, Poniatowicz-Frasunek Ewa, Wypych Marek, Chrapko Beata
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.254-268, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • farmacja
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2019/2523

    Tytuł oryginału: Attitudes of young people towards problems connected with human procreation.
    Tytuł polski: Postawy młodzieży wobec zagadnień związanych z prokreacją człowieka.
    Autorzy: Skórzyńska Hanna, Pacian Anna, Grochowski Leszek
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.269-277, il., bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • seksuologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska


    2020/2523

    Tytuł oryginału: Histological and ultrastructural investigations of placenta villi in intrauterine growth resection of fetuses (IUGR).
    Tytuł polski: Badania histologiczne i ultrasonograficzne kosmków łóżyska w wewnątrzmacicznym zahamowanym rozwoju płodu (IUGR).
    Autorzy: Wawrzycka Bożena, Zarębska Alicja, Wawrzycki Bartłomiej, Matusiewicz Janusz, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.409-414, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska
  • ciąża


    2021/2523

    Tytuł oryginału: Collagenoses and cutaneous manifestations of hepar diseases.
    Tytuł polski: Kolagenozy i skórne manifestacje chorób komórki wątrobowej.
    Autorzy: Pietrzak Aldona, Czelej Dorota, Pietrzak Bogusław
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.415-418, bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2022/2523

    Tytuł oryginału: The liver and its ultrasonographic picture in children suffering from vitiligo.
    Tytuł polski: Wątroba i jej obraz ultrasonograficzny u dzieci chorujących na bielactwo.
    Autorzy: Pietrzak Aldona, Dybiec Ewa, Urban Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.419-425, tab., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska


    2023/2523

    Tytuł oryginału: Changes of resistance parameters of femoral bone in adult female rats after apllication of zoladex and vincristin.
    Tytuł polski: Zmiany parametrów wytrzymałościowych kości udowej u dorosłych samic szczurów po zastosowaniu zoladexu i winkrystyny.
    Autorzy: Nadulska Anna, Klukowska Lidia, Dyba Stefan
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.426-430, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • traumatologia i ortopedia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury


    2024/2523

    Tytuł oryginału: The combined effect of systemic hypertension and obesity on biventricular diastolic function.
    Tytuł polski: Złożony wpływ nadciśnienia tętniczego i otyłości na czynność rozkurczową obu komór serca.
    Autorzy: Myśliński Wojciech, Mosiewicz Jerzy, Dzida Grzegorz, Hanzlik Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.431-436, il., tab., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    2025/2523

    Tytuł oryginału: Arthrogryposis multiplex congenita (AMC) - case report.
    Tytuł polski: Arthrogryposis multiplex congenita (AMC) - opis przypadku.
    Autorzy: Mielnik-Błaszczak Maria, Borowska Małgorzata
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.437-441, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.


    2026/2523

    Tytuł oryginału: Oral hygiene in children with Down's syndrome.
    Tytuł polski: Stan higieny jamy ustnej u dzieci z zespołem Downa.
    Autorzy: Pels Elżbieta, Mielnik-Błaszczak Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.442-447, il., tab ., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • pediatria
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie


    2027/2523

    Tytuł oryginału: Regaining functional independence by neurological patients.
    Tytuł polski: Ocena niezależności funkcjonalnej pacjentów neurologicznych.
    Autorzy: Adamczyk Kazimiera, Jakubaszek Ewa, Ksykiewicz-Dorota Anna, Zajko Anna, Lorencowicz Regina, Szczepanik Mirella
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.448-453, bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pielęgniarstwo
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2028/2523

    Tytuł oryginału: The study of the level of self-care among neurological patients.
    Tytuł polski: Badanie poziomu samoopieki u pacjentów neurologicznych.
    Autorzy: Adamczyk Kazimiera, Wysokiński Mariusz, Jakubaszek Ewa, Zajko Anna, Szczepanik Mirella, Lorencowicz Regina
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.454-458, il., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pielęgniarstwo
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2029/2523

    Tytuł oryginału: The influence of nonsteroidal anti-inflammatory drugs abuse and chronic stress on the development of necrotizing fasciitis - case report.
    Tytuł polski: Wpływ nadużywania niesterydowych leków przeciwzapalnych oraz przewlekłego stresu na rozwój martwiczego zapalenia powięzi - opis przypadku.
    Autorzy: Myśliński Wojciech, Mosiewicz Jerzy, Kazubek Maria, Przyszlak-Szabała Małgorzata, Krupski Witold, Pęgiel-Sićko Ewelina, Hanzlik Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.459-462, il., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska


    2030/2523

    Tytuł oryginału: The value of spatial reconstructions with computed tomography (3D CT) in recognising the fissure of vertebral arch.
    Tytuł polski: Wartość rekonstrukcji przestrzennych tomografii komputerowej (3D TK) w rozpoznawaniu szczeliny łuku kręgu.
    Autorzy: Krupski Witold, Majcher Piotr, Fatyga Marek, Złomaniec Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.463-470, il., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie


    2031/2523

    Tytuł oryginału: The value of radiological examination in postoperative diagnostics of cardiospasm.
    Tytuł polski: Wartość badania radiologicznego w pooperacyjnej diagnostyce kurczu wpustu.
    Autorzy: Krupski Witold, Mądro Przemysław, Ćwik Grzegorz, Kusz Wojciech, Wallner Grzegorz, Złomaniec Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.471-477, il., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2032/2523

    Tytuł oryginału: Lipid and hormone profile in psoriatic females.
    Tytuł polski: Stężenie lipidów i hormonów u kobiet z łuszczycą.
    Autorzy: Pietrzak Aldona, Lecewicz-Toruń Barbara, Jakimiuk Artur
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.478-483, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska


    2033/2523

    Tytuł oryginału: Interleukin-18 serum concentration in patients with psoriasis triggered by infection.
    Tytuł polski: Stężenie IL-18 w surowicy pacjentów z łuszczycą poinfekcyjną.
    Autorzy: Pietrzak Aldona, Lecewicz-Toruń Barbara, Roliński Jacek
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.484-490, tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska


    2034/2523

    Tytuł oryginału: Burdensome factors occurring at school according to students.
    Tytuł polski: Czynniki uciążliwe w szkole w opinii uczniów.
    Autorzy: Pikuła Anna, Święs Zofia, Borzęcki Andrzej, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.491-495, il., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pediatria
  • ochrona środowiska

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska


    2035/2523

    Tytuł oryginału: Changes in serum concentrations and in cytokine production by blood cell cultures of a patient with major depression - case report.
    Tytuł polski: Zmiany poziomu cytokin surowiczych oraz indukowanych w hodowli komórek krwi pacjenta chorego na depresję - opis przypadku.
    Autorzy: Dubas-Ślemp Halina, Kamińska Teresa, Marmurowska-Michałowska Halina, Kandefer-Szerszeń Martyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.496-504, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska


    2036/2523

    Tytuł oryginału: Anxiety and fear level in patients after myocardial infarction over five years of rehabilitation.
    Tytuł polski: Poziom niepokoju i lęku u chorych po zawale serca w okresie pięcioletniej rehabilitacji.
    Autorzy: Nasiłowska-Barud Alicja
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.505-513, il., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    2037/2523

    Tytuł oryginału: The assessment of the 12-year-olds' dental care in rural areas.
    Tytuł polski: Ocena opieki stomatologicznej nad dziećmi 12-letnimi ze środowiska wiejskiego.
    Autorzy: Mielnik-Błaszczak Maria, Stanios-Śnieżyńska Jolanta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.514-518, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pediatria
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska


    2038/2523

    Tytuł oryginału: Retrospective analysis of mortality rates among the patients with cerebral stroke hospitalized at the Department of Neurology of the Medical University of Lublin in 1990 and 2000.
    Tytuł polski: Retrospektywna ocena częstości zgonów w udarach mózgowych u chorych hospitalizowanych w latach 1990-2000 w Klinice Neurologii AM w Lublinie.
    Autorzy: Mitosek-Szewczyk Krystyna, Miazga Monika, Miazga Mirosław, Piecyk Marta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.519-525, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2039/2523

    Tytuł oryginału: Histological examination of the lacrimal gland after experimental administration of Cladribine.
    Tytuł polski: Histologiczna ocena gruczołu łzowego po eksperymentalnym podaniu Kladrybiny.
    Autorzy: Kwietniewska Małgorzata, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.526-530, il., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • króliki


    2040/2523

    Tytuł oryginału: The occurrence of primary open angle glaucoma in a family.
    Tytuł polski: Rodzinne występowanie jaskry pierwotnej otwartego kąta.
    Autorzy: Lewandowska-Furmanik Maria, Matysik Anna, Pietraś-Trzpiel Małgorzata
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.531-534, il., bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • okulistyka
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska


    2041/2523

    Tytuł oryginału: Hospital urinary tract infections in surgical patients.
    Tytuł polski: Szpitalne zakażenia dróg moczowych u pacjentów chirurgicznych.
    Autorzy: Sakwa Wojciech, Polkowski Wojciech, Chmurzyński Marek, Wallner Grzegorz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.535-541, tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • chirurgia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie


    2042/2523

    Tytuł oryginału: Risk factors of infection in surgical wounds.
    Tytuł polski: Czynniki ryzyka zakażenia ran operacyjnych.
    Autorzy: Sakwa Wojciech, Polkowski Wojciech, Chmurzyński Marek
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.542-548, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2043/2523

    Tytuł oryginału: The influence of application of 3D CT reconstructions on classification of maxillofacial fractures.
    Tytuł polski: Wpływ zastosowania rekonstrukcji trójwymiarowych TK na klasyfikację złamań twarzoczaszki.
    Autorzy: Różyło-Kalinowska Ingrid
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.549-555, il., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie


    2044/2523

    Tytuł oryginału: Tumour's angiogenesis - the function of VEGF and bFGF in colorectal cancer.
    Tytuł polski: Angiogeneza w guzie - rola VEGF i bFGF w raku jelita grubego.
    Autorzy: Kos Marek, Dąbrowski Andrzej
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.556-561, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2045/2523

    Tytuł oryginału: The correlation of US and CT values in the diagnostics of giant pseudo-cysts of the liver.
    Tytuł polski: Korelacje wartości USG i TK w diagnostyce olbrzymich torbieli rzekomych wątroby.
    Autorzy: Krupski Witold, Szafranek Joanna, Pasławski Marek, Złomaniec Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.562-569, il., bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie


    2046/2523

    Tytuł oryginału: The effect of chronic alcohol abuse on gastric and duodenal mucosa.
    Tytuł polski: Wpływ przewlekłego nadużywania alkoholu na błonę śluzową żołądka i dwunastnicy.
    Autorzy: Bienia Anna, Sodolski Wojciech, Luchowska Elżbieta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (2) s.570-582, il., tab., bibliogr. 29 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska


    2047/2523

    Tytuł oryginału: VEGF in the culture of PMN and the serum in oral cavity cancer patients.
    Autorzy: Jabłońska E., Piotrowski L., Jabłoński J., Grabowska Z.
    Źródło: Oral Oncol. 2002: 38 (6) s.605-609, tab., bibliogr. 30 poz.
    Sygnatura GBL: 312,987

    Hasła klasyfikacyjne GBL:
  • onkologia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Vascular endothelial growth factor (VEGF) is a multification cytokine that plays a pivotal role in angiotensin in vivo. In the present study we examinated the ability of polymorphonuclear neutrophils (PMN) to secrete VEGF confrontated with the serum levels in oral cavity cancer patients. To investigate whether VEGF may have a prognostic importance, its value in the serum and the culture supernatans was related to the clinical course of patients. The level pof VEGF in the culture supernatant of PMN from patients were significantly higher than those from control. Increased VEGF production by PMN according to clinical progression disease, observed in the present study, seems to suggest a stimulating role of tumour cells in VEGHF production by PMN. Additionally a decrease in the ability of PMN to VEGF release after surgery may be caused by a eremoval of the tumour mass and then the lack the effects of tumour cells on PMN function. Results obtained appear to suggest than PMN can contribute significantly to the initiotion and amplifiocation of tumour angiogenesis and metastasis in oral cavity cancer patients. Increased values of VEGF with progression of disease and decreased values after surgery treatment clearly suggest that VEGF can paly as a tumor marker in oral cavity cancer patients.


    2048/2523

    Tytuł oryginału: Solvent microextraction in routine toxicological analysis of amphetamine and metaphetamine.
    Tytuł polski: Zastosowanie mikroekstrakcji rozpuszczalnikowej w rutynowej analizie toksykologicznej amfetaminy i metamfetaminy w próbkach moczu.
    Autorzy: Janus Tomasz, Borowiak Krzysztof S., Potocka Barbara, Jarmołowicz Zofia
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.143-151, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Amfetamina i jej pochodne należą do najczęściej notowanych środków uzależniających spotykanych w codziennej praktyce laboratoriów toksykologicznych. Z uwagi na silne efekty psychomimetyczne a także toksyczne działanie narządowe preparaty te budzą stałe, uzasadnione zainteresowanie toksykologów. Opracowanie szybkich, specyficznych metod analitycznych pozwalających na oznaczenie tych ksenobiotyków to nadal aktualny problem dla środowiska toksykologów-analityków. Tym bardziej, że zgodnie z zaleceniami Światowego Komitetu ds. Narkotyków oraz producentów testów, wyniki analizy immunoenzymatycznej - najczęściej stosowanej rutynowo techniki dla oznaczania środków narkotycznych, wymagają potwierdzenia procedurami opartymi o inne techniki analityczne. W pracy przedstawiono zastosowanie oryginalnej, własnej metodyki pozwalającej na szybkie i pewne, równoczesne oznaczanie amfetaminy i metamfetaminy w materiale biologicznym. Metodę oparto na technice mikroekstrakcji ciecz-ciecz dla wyodrębnienia ksenobiotyków z materiału biologicznego oraz ich analizie jakościowej i ilościowej techniką chromatografii gazowej z detektorem FID.

    Streszczenie angielskie: The use of solvent microextraction technique for GC-FID analysis of amphetamine and metamphetamine in biological fluid has been presented. Based on this technique, simple and cheap method was worked out for fast toxicological quantitative and qualitative analysis of amphetamines. The method was found to be especially useful for the confirmation of results obtained in immunological assays, that are often charged with false positive outcomes. Validation of the described method was performed. Linearity was maintained within the concentration range: 500 ng - 9000 ng for amphetamine, 1000 - 7000 ng for metamphetamine. We concluded that the developed technique can be applied for routine toxicological analysis of amphetamine and metamphetamine in biological samples.


    2049/2523

    Tytuł oryginału: Distribution of naproxen, dibenzepin and promazine in various tissues after acute overdosage.
    Tytuł polski: Dystrybucja naproksenu, dibenzepiny i promazyny w różnych tkankach organizmu człowieka po ostrym przedawkowaniu.
    Autorzy: Bączek Tomasz, Kaliszan Michał, Szpiech Beata
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.153-158, tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Oznaczono stężenia naproksenu, dibenzepiny i promazyny w różnych tkankach organizmu człowieka post mortem po ostrym przedawkowaniu leków, z wykorzystaniem wysokosprawnej chromatografii cieczowej (HPLC). Porównano stężenia badanych leków zmierzone we krwi, soku żołądkowym, mózgu, wątrobie i nerkach. Oceniono dystrybucję leków w poszczególnych tkankach. Dystrybucję odniesiono do parametru lipofilności, log P (logarytm ze współczynnika podziału n-oktanol/woda) badanych leków. Znaleziono względną korelację pomiędzy poziomem leków w krwi i ich lipofilnością. Relacje pomiędzy stosunkami stężenia leku w różnych tkankach i wartościami log P nie są jednak jednoznaczne i wskazują na możliwość wstępowania specyficznego mechanizmu transportu przez błony biologiczne podczas procesu dystrybucji, obok dyfuzji biernej. Wysokie stężenie dibenzepiny i promazyny w mózgu były prawdopodobnie przyczyną śmierci ofiary.

    Streszczenie angielskie: Concentration of naproxen, dibenzepin and promazine in blood, gastric juice, brain, liver and kidney was determined in biological material taken post morten after acute overdosage, from a female aged 31, by means of high performance liquid chromatography (HPLC). Distribution of the drugs was related to their lipophilicity parameter, log P (logarithm of n-octanol-water partition coefficient). Blood levels of the drugs seemed to correlate with their lipophilicity. However, the relations between drug concentration ratios in different tissues and log P are not straightforward and indicate that not only passive diffusion but also some specific membrane tranport mechanisms are involve in distribution. High concentrations of dibenzepin and promazine in the brain were the most probable cause of death of the suicide.


    2050/2523

    Tytuł oryginału: Accumulation of cadmium, lead and mercury in human placenta as a consequence of maternal cigarette smoking.
    Tytuł polski: Akumulacja kadmu, ołowiu i rtęci w łożysku ludzkim jako konsekwencja palenia papierosów przez matkę.
    Autorzy: Czekaj Piotr, Pałasz Artur, Donica Ewa, Karczewska Weronika
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.159-168, il., bibliogr. 31 poz., streszcz. - 8 Kongres Polskiego Towarzystwa Toksykologicznego Łódź 08-11.09. 2002
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • sprawozdanie
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płód
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie polskie: Palenie papierosów zwiększa niebezpieczeństwo akumulacji metali ciężkich w łożysku i w narządach płodu. W przedstawionej pracy zastosowano metodę AAS w celu określenia stężeń Cd, Pb i Hg w łożyku matek narażających się na działanie dymu papierosowego w czasie ciąży. Poziom ekspozycji określano na podstawie wywiadu ( 10 papierosów na dzień; 10 papierosów na dzień) oraz oznaczeń kotyniny w moczu. Wykazano akumulację Cd i Hg oraz niezmieniony poziom Pb w łożysku kobiet palących. Różnice między grupami kobiet palących nie były statystycznie istotne.

    Streszczenie angielskie: Cigarette smoking increases the danger of havy metal accumulation within placenta and foetal organs. In the presented study, AAS method was applied to determine concentrations of Cd, Pb and Hg in placentas from mothers exposed to cigarette smoke during pregnancy. Level of exposure was estimated based on interview (, 10 cigarettes a day; 10 cigarettes a day) and cotinine levels in patients' urine. In placentas from smoking women, accumulation of Cd and Hg and unchanged concentration of Pb were shown. Differences between groups of women smoking different amounts of cigarettes a day weren't statistically significant.


    2051/2523

    Tytuł oryginału: Distribution of selected metals in pregnant and foetal rat tissues under exposure to cigarette smoke.
    Tytuł polski: Akumulacja metali w narządach ciężarnych szczurów oraz w wątrobie płodowej w warunkach narażenia na działanie dymku papierosowego.
    Autorzy: Czekaj Piotr, Pałasz Artur, Donica Ewa, Florek Ewa
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.169-179, il., bibliogr. 40 poz., streszcz. - 8 Kongres Polskiego Towarzystwa Toksykologicznego Łódź 08-11.09. 2002
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie polskie: Narażenie na działanie dymu papierosowego zwiększa niebezpieczeństwo akumulacji metali ciężkich, które m.in. wchodzą w liczne interakcje z pierwiastkami śladowymi. W przedstawionej pracy zastodsowano metodę AAS w celu określenia zmian stężeń Cd, Pb, Zn, Cu i Fe w czasie ciąży i w warunkach ekspozycji na dym papierosowy w narządach szczurów dojrzałych (płuca, serce, wątroba, mózg, nerki) i w wątrobie płodów szczurzych. Samice szczurów szczepu Wistar były poddane działaniu dymu papierosowego w dawce odpowiadającej 1500 mg CO/m**3, 6 h/dobę, 5 dni w tygodniu, przez 3 tygodnie. Skuteczność ekspozycji określano na podstawie oznaczeń nikotyny i kotyniny w moczu. Wykazano akumulację Cd i Pb w płucach, sercu i nerkach szczurów dojrzałych; Cd w łożysku, Zn w nerkach oraz Cu w płucach zwierząt eksponowanych. Wpływ ciąży zaznaczał się najsilniej poprzez obniżenie zawartości badanych metali w płucach zwierząt poddanych działaniu dymu oraz podwyższenie stężenia Zn w nerkach.

    Streszczenie angielskie: Cigarettes smoking increases exposure to heavy metals which can interact with trace elements. Smoking- and pregnancy-associated changes in Cd, Pb, Zn, Cu and Fe concentrations were examined by atomic absorption spectrometry in adult rat lungs, heart, brain and kidneys; and adult and foetal rat liver. Wistar female rats were exposed to cigarette smoke at a CO concentration of 1500 mg/m**3 6 h per day, 5 days per week, for 3 weeks. Levels of urine nicotine and cotinine were used as measures of exposure. An intensified accumulation of: Cd and Pb in adult rat lungs, heart and kidneys; Cd - in placenta; Zn - in kidneys and Cu - in lungs of exposed rats were observed. Pregnancy-associated decrease of metals content was observed in exposed rat lungs. Tendency for pregancy-dependent Zn accumulation was found in rat kidneys.


    2052/2523

    Tytuł oryginału: In vitro and in vivo studies on the effect of selected pesticides on the number of antibody secreting cells (ASC) and specific immune response in carp (Cyprinus Carpio L).
    Tytuł polski: Badania in vitro oraz in vivo nad wpływem wybranych pestycydów na liczbę komórek produkujących przeciwciała (ASC) oraz swoistą odpowiedź immunologiczną karpia (Cyprinus Carpio L).
    Autorzy: Rymuszka Anna, Siwicki Andrzej K., Studnicka Maria, Sierosławska Anna, Bownik Adam, Kazuń Krzysztof
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.181-189, il., bibliogr. 32 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • in vitro

    Streszczenie polskie: Prezentowane badania miały na celu określenie na modelu ryba wpływu cypermetryny oraz atrazyny na liczbę komórek produkujących przeciwciała (ASC), po podaniu szczepionki FUROGEN. W badaniach in vitro komórki izolowano ze śledziony immunizowanej szczepionką i hodowanej w medium RPMI - 1640 z dodatkiem różnych stężeń cypermetryny oraz różnych stężeń atrazyny. W badaniach in vivo ryby poddano 1 godz. intoksykacji wybranymi pestycydami, a następnie po 24 godz. podano dootrzewnowo szczepionkę Furogen. Badano ogółem liczbę komórek produkujących przeciwciała oraz liczbę komórek zdolnych do produkcji swoistych przeciwciał przy użyciu metody ELISPOT. Uzyskane wyniki badań wskazują na immunotoksyczne działanie użytych stężeń cypermetryny. Atrazyna w najwyższych zastosowanych stężeniach powoduje statystycznie istotne obniżenie ogólnej liczby komórek produkujących przeciwciała.

    Streszczenie angielskie: Experimental studies carried out on animals have proved immunotoxic action of some pesticides and their metabolites. The purpose of the present study was to determine the effect of cypemethrin and atrazine on the number of the antibody secreting cells after application of Furogen vaccine. In the in vitro studies cells were isolated from spleens which were immunized by vaccine and cultivated in RPMI - 1640 medium with different concentrations of cypermethrin and atrazine. In the in vivo studies, fish were intoxicated for 1 hour by selected pesticides, and then after 24 hours were given an intraperitoneal injection of Furogen vaccine. Total number of antibody secreting cells (ASC) and the number of cells competent to produce specific antibodies were studied, using ELISPOT assay. Influence on the titres of specific antibodies was also examined. The results showed the suppressive effects pesticides on cell - mediated and humoral - immune response in carp.


    2053/2523

    Tytuł oryginału: Effect of fibrates on the branched-chain ŕ-ketoacid dehydrogenase complex in rat liver.
    Tytuł polski: Wpływ fibratów na kompleks dehydrogenazy rozgałęzionych ŕ-ketokwasów w wątrobie szczura.
    Autorzy: Knapik-Czajka Małgorzata, Cyganek Izabela, Tyszka-Czochara Małgorzata, Francik Renata, Jaśkiewicz Jerzy
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.191-198, tab., bibliogr. 25 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Celem pracy była ocena wpływu wybranych fibratów na aktywność kompleksu dehydrogenazy rozgałęzionych ŕ-ketokwasów (BCKDH), kluczowego enzymu katabolizmu rozgałęzionych aminokwasów w wątrobie szczurów. Badano także wpływ fibratów na aktywność kinazy BCKDH, enzymu regulatorowego kompleksu BCKDH. Badania przeprowadzono na szczurach Wistar (samcach), które żywiono przez okres 14 dni paszą standardową (20 proc. białka) lub niskobiałkową (8 proc. białka - grupa kontrolna) bez dodatku fibratów bądź niskobiałkową z dodatkiem klofibratu, bezafibratu i fenofibratu w stężeniu 0,5 proc. W homogenatach wątroby oznaczano spektrofotometrycznie aktywność całkowitą oraz aktualną kompleksu BCKDH oraz aktywność kinazy BCKDH. Na ich podstawie obliczono stan aktywności kompleksu BCKDH. U zwierząt żywionych paszą standardową oraz niskobiałkową stwierdzono porównywalny przyrost masy ciała. U szczurów karmionych paszą z klofibratem i bezafibratem wykazano brak przyrostu masy ciała, zaś karmionych paszą z fenofibratem spadek masy ciała. Bezwzględna masa wątroby zwierząt żywionych paszą z dodatkiem klofibratu i bezafibratu była większa, zaś u szczurów karmionych paszą z dodatkiem fenofibratu nie różniła się w stosunku do grupy kontrolnej. Aktywność aktualna, całkowita oraz stan aktywności kompleksu BCKDH były znamiennie niższe, natomiast aktywność kinazy BCKDH była wyższa u szczurów karmionych paszą niskobiałkową w stosunku do grupy otrzymującej paszę standardową. Dodatek fibratów do paszy niskobiałkowej spowodował wzrost aktywności aktualnej, całkowitej i stanu aktywności BCKDH oraz spadek...

    Streszczenie angielskie: This study investigated the effect of fibrates on branched-chain ŕ-ketoacid dehydrogenase complex (BCKDH) and BCKDH kinase activities in rat liver. Wistar male rats were fed ad libitum for 14 days low-protein chow (8 p.c. protein) with 0,5 p.c. of selected fibrates: clofibrate, bezafibrate and fenofibrate. BCKDH complex enzymes were determined spectrophotometrically in extracts of freeze-clamped liver. Addition of fibrates to low-protein chow caused an increase in both actual and total activities of BCKDH complex as well as in activity state of BCKDH. On the contrary BCKDH kinase activity was diminished. Our results prove that fibrates impair physiological regulation of BCKDH complex activity, thereby disturbing branched-chain aminoacids catabolism.


    2054/2523

    Tytuł oryginału: The ABCs of research on pulsatile versus nonpulsatile perfusion during cardiopulmonary bypass.
    Autorzy: šndar Akif
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.ED21-ED24, bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The literature suggests that pulstatile flow should be routinely used during cardiopulmonary bypass (CPB) in moderate- to high-risk cardiac surgery patients, especially those who must undergo more than 45 minutes of aortic crosslamping. Nevertheless, the use of pulsatile versus nonpulsatile perfusion remains controversial, mainly owing to a lack of precise, complete quantification of pressure-flow waveforms. This editorial briefly summarizes the major factors, or "basic ABCs", that affect the validity of research in this area. A. Because pulsatile flow depends on an energy gradient, investigators must quantify the difference in the hemodynamic energy levels produced by specific pulsatile and nonpulsatile pumps before meaningufl direct comparison of these two perfusion modes can be possible. B. The energy equivalent pressure (EEP) formula should be used for this purpose. C. In conducting clinical trials of the perfusion modes, reseearches must use appropriate patent-selection criteria, use pulsatile flow continuously during CPB, and choose extracorporeal-circuit components carefully. By following these basic ABCs, research will produce more valid and meaningful results that will translate into better outcomes for CPB patients.


    2055/2523

    Tytuł oryginału: The influence of sex hormones on circulating nitric oxide (NOx) levels in Rhesus monkeys (Macaca Mulatta).
    Autorzy: Khorram Omid, Colman Ricki J., Kemnitz Joseph W., Magness Ronald R., Zhang Jian, Yao Zhi, Keller Evan T.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR489-BR495, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • małpy
  • płeć żeńska

    Streszczenie angielskie: Background: The effects of long-term estrogen (E2) replacement therapy (ERT) on circulating and bone marrow total plasma nitric oxide (NOx) levels were determined in rhesus monkeys. In addition changes in circulating NOx during the menstrual cycle were measured. We measured Nox levels in 20 ovariectomized animals and 27 cycling animals. In the first group monkeys were ovariectomized (OVX; n=10) and treated with estrogen implants for 21 months. The control group (n=10) was OVX and received vehicle implants only. After 21 months systemic NOx status was measured. In a second group of cycling animals NOx was measured during the follicular and luteal phases, and correlated whit body comparison parameters determined by dual energy X-ray absorptiometry (DXA) analysis. Results: Replacement of estrogen in OVX monkeys resulted in reduced circulating but not bone marrow plasma NOx compared to OVX monkeys. Circulating NOx levels in these animals correlated negatively (rý= -0.35; P=0.03) with estradiol levels. In cycling monkeys luteal levels of NOx were found to be significantly higher than follicular levels and correlated negatively (rý=-0.4; P=0.036) with estradiol but not progesterone levels. Negative correlations between NOx levels and body weight, fat and lean mass were also found. Conclusion: Long-term ERT influences systemic NOx levels in negative fashion without effects on bone marrow plasma NOx. Circulating NOx was higher during the luteal phase. In both ERT treated and cycling monkeys estradiol co\related negatively with NOx suggesting the existence of a negative...


    2056/2523

    Tytuł oryginału: Actions of paracetamol on cyclooxygenases in tissue and cell homogenates of mouse and rabbit.
    Autorzy: Świerkosz Tomasz A., Jordan Lynne, McBride Melissa, McGough Kevin, Devlin Jean, Botting Regina M.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR496-BR503, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • myszy

    Streszczenie angielskie: Background: Paracetamol is a potent analgesic and antipyretic drug, but has only weak anti-inflammatory activity. Unlike aspirin-like drugs, paracetamol does not damage the stomach mucosa or inhibit the aggregation of platelets. The analgesic action of paracetamol is on the central nervous system. In vitro, paracetamol inhibits cyclooxygenase (COX)-1 and -2 in high concentrations but stimulates in low doses. This study examines the stimulation and inhibition of COX-1 and COX-2 in homogenates of mouse and rabbit tissues and in J774.2 cultured mouse macrophages. Material and methods: Mouse and rabbit tissues were removed, homogenised and treated with different concentrations of paracetamol. Prostaglandins (PGs) E2 and I2 were measured in the homogenates to assess the activity of COX-1. Ex vivo synthesis of PGE2 was measured in tissues after treating rabbits with 100 mg/kg paracetamol. J774.2 cultured mouse macrophages treated with bacterial lipopolisaccharide (LPS) to induce COX-2, were treated with varying concentrations of paracetamol and the PGs produced were measured. Results: Low doses of paracetamol stimulated PG production in J774.2 macrophages and stomach mucosa homogenates, but reduced PG production at high concentrations of paracetamol. This stimulation did not occur when co-factors were added. The order of potency of paracetamol on COX-1 or COX-2 in tissue homogenates was as follows: lungs spleen brain J774.2 cells stomach mucosa. Paracetamol, 100 mg/kg, inhibited COX-1 in stomach mucosa ex vivo much less effectively than in other tissues. Conclusions: These...


    2057/2523

    Tytuł oryginału: Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist.
    Autorzy: Kahn Larry E., Doshi Parul, McGarity Kelly L., Yu Minfu, Bono Christine P., Lie Wen-Rong, Rankin Anne M., Smidt Mary L., Streeter Philip R., Klein Barbara K., Welply Joseph K., Woulfe Susan L.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR504-BR514, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: Background: Progenipoietin-4 (ProGP-4) is an E. coli derived chimeric growth factor that activates the human Flt3 and G-CSF receptors. ProGP-4 possesses cross-species activity and treatment of mice with ProGP-4 results in increas in the number of WBC and Class II+/CD11c+ cells in both spleen and peripheral blood. Herein, we report morphologic, phenotypic and functional evaluation of Class II+/CD11c+ cells generated by in vivo administration of ProGP-4. Material and methods: C57BL/6 mice were injected daily with ProGP for 7 to 18 days. Leukocytes from spleen and peripheral blood were analyzed by flow cytometry to enumerate and characterize changes in DC populations. Spleens from ProGP treated mice were evaluated by immunocytochemistry and enriched CD11c+ populations were functionally assessed in a mixed lymphocyte assay and in an antigen dependent CTL assay. Results: Administration of this dual receptor agonist to mice resulted in dose-dependent increases in the numbers of total white blood cells and Class II+/CD11c+ cells in spleen and peripheral blood. CD11c+ cells from ProGP-4 treated mice co-expressed DEC205 and also expressed CD80, CD86 and CD40, albert at lower levels as compared to Class II+/CD11c+ cells from untreated animals. Despite lower co-stimulatory molecule expression, PorGP-4 generated ClassII+/CD11c+ cells stimulated proliferation of allogenic T cells and an antigen-specific T cell hybridoma as efficiently as bone marrow derived dendritic cells from untreated mice. Conclusion: The data presented in this report highlight the ability of E. coli derived...


    2058/2523

    Tytuł oryginału: Critical evaluation of radiolabeled lymphocytes to detect acute renal transplant rejection in a large animal model.
    Autorzy: Petronis John D., Kittur Dilip S., Wilasrusmee Chumpon
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR515-BR520, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • transplantologia
  • radiologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnie

    Streszczenie angielskie: Background: Renal transplant rejection cannot be diagnosed with certainly by non-invasive techniques. These techniques lack the specificity to differentiate rejection from other causes of renal dysfunction such as ATN and calcineuria toxicity. Since rejection involves lymphocytes, which the other course of dysfunction do not, radiolabelling lymphocytes is an attractive technique to diagnose rejection non-invasively. Material and methods: We report our experience with this technique in a pig model of renal transplantation. We studied two groups of pigs, one with renal autografts and the other with allografts. We optimized radiolabelling of lymphocytes and also the technology for detection of these lymphocytes. The uptake of the radiolabeled lymphocyte was compared between the two groups by surface detection and, at the end of the experiment, with scintigraphy of renal tissues. Results: Despite adequate labeling and viability of lymphocytes, only 1-2 p.c. of injected lymphocytes 'homed' to the renal grafts. Furthermore, although the detection technology was optimized, a poor signal to noise ratio interfered with the detection of the labeled lymphocytes. Due to these problems rejection could not be differentiated from ATN in this model. Conclusion: We conclude that increasing the specific activity of the lymphocytes and improving the signal to noise ratio will enhance the specificity and sensitivity of this technique and facilitate noninvasive diagnosis of rejection.


    2059/2523

    Tytuł oryginału: Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells.
    Autorzy: Camirand Anne, Lu Yuhong, Pollak Michael
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR521-BR526, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Background: The humanized anti-HER2 monoclonal antibody trastuzamab (Herceptin) is useful in the treatment of ErbB2-overexpressing breast cancers, but its efficiency is limited because development of resistance is common. In order to study the possibility of improving the efficacy of therapies directed against HER2/erbB2, we investigated the effects of co-targeting this receptor and the insulin-like growth factor 1 receptor (IGF-1R), a widely-expressed protein tyrosine kinase with important roles in suppression of apoptosis and stimulation of proliferation. Material/methods: The experimental strategy involved combining trastuzumab treatment and reduction of IGF-1R signaling through incremental heat-induced expression of the dominant-negative IGF-1 receptor 486/STOP under the control of the heat-sensitive Drosophila HSP70 promoter, in HER2/erbB2-overexpressing MCF7her 18 breast cancer cells. Results: Isobologram analysis of combinatorial treatment data revealed a strong synergistic interaction between trastuzumab treatment and the indication of the dominant-negative IGF-1R expression, resulting in potentiation of growth inhibition in transfected cancer cells. Conclusions: These observations support the concept that simultaneously co-targeting tyrosine kinase receptors may be therapeutically useful, and provide a specific rationale for combining IGF-1R and HER2/erbB2 targeting strategies in anti-neoplastic approaches.


    2060/2523

    Tytuł oryginału: Melatonin effects on megakaryocyte membrane patch-clamp outward K+ current.
    Autorzy: Di Bella Luigi, Bruschi Carla, Gualano Luciano
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR527-BR531, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • psy
  • in vitro

    Streszczenie angielskie: Background: This study was carried out to evaluate the influence of melatonin concentration on rat bone marrow megakaryocyte outward K+ current and its implications with regard to platelet production. It is the Author's view that the greatly extended development of megakaryocyte membrane, together with its ion channels, makes the choice of this topic particularly pertinent. Material and methods: megakaryocytes from fresh Wistar rat bone marrow were clampaged with patch-clamp technique and the examination of membrane outward current was performed when melatonin dissolved in external or internal standard solution was used. Results: On the basis of this study, melatonin does reduce outward K+ current intensity, the more the higher the melatonin concentration. In quantitative terms, whereas no change is noticed when dissolved melatonin concentration in external standard solution is smaller than 25 ćM, at 50 ćM only a delayed outward current decrease appears. The effect on the outward current intensity is reversible at least until melatonin concentration reaches 500 ćM; when melatonin concentration is higher than 1000 ćM the effects is demonstrably irreversible. The presence on the megakaryocyte membrane of internal standard melatonin solution does reduce the outward current even more sharply. Conclusions: There seems to be a positive correlation beween cationic pump and megakaryocyte intimate processes of platelet production.


    2061/2523

    Tytuł oryginału: Agonists of peroxisome-proliferator activated receptor-ŕ (Clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat.
    Autorzy: Sivarajah Ahila, Chatterjee Prabal K., Hattori Yoshiyuki, Brown Paul A. J., Stewart Keith N., Todorovic Zoran, Mota-Filipe Helder, Thiemermann Christoph
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR532-BR539, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: The aim of this study was to investigate the effects of peroxisome-proliferator activated receptor-ŕ (PPAR-ŕ) agonsits, clofibrate and WY 14643 on the renal dysfunction and injury caused by bilateral ischemia/reperfusion (I/R) of rat kidneys in vivo. Material/Methods: Male Wistar were randomized with sodium thiopentone (120 mg/kg i.v.) and subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h). Serum and urinary biochemical indicators of renal dysfunction and injury were meausured; serum creatine (sCr, glomerular dysfunction), fractional excretion of Na+ (FE NA, tubular dysfunction), and urinary N-acetyl-á-D-glucosaminidase (uNAG, tubular injury). Additionally, renal sections were used for histological grading of renal injury and for RT-PCR analysis of the expression of PPAR-isoforms in kidneys obtained from rats prior to or after I/R. In addition, expression of intercellular adhesion molecule-1 (ICAM-1) was determined using Northern blot analysis. Results: Using RT-PCR we document here the expression of PPAR-ŕ, PPAR-á and PPAR-ç1 (but not PPAR-ç2) in the kidney of the rat. I/R resulted in the down-regulation of PPAR-ŕ without modulation of any other PPAR. Clofibrate and WY 14643 significantly reduced the increases in sCr, FE NA and uNAG caused by renal I/R, indicating attenuation of renal dysfunction and injury. Expression of ICAM-1 caused by I/R of the kidney was not modulated by PPAR-ŕ agonists. Conclusions: We show here that (i) renal I/R results in the down-regulation of PPAR-ŕ in the kidney, and (ii) that the PPAR-ŕ agonists...


    2062/2523

    Tytuł oryginału: Activity of cysteine proteases and their inhibitors in the lymph nodes of larynx cancer patients.
    Autorzy: Siewiński Maciej, Berdowska Izabela, Mikulewicz Wojciech, Wnukiewicz Jan, Gutowicz Jan
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.BR540-BR544, tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Cysteine endopeptidases and their inhibitors play an important role in the process of carcinogenesis. Positive correlation has been found between tumor invasiveness, its metastatic potential and the secretion of cyseine endopepetidases. Cysteine protease inhibitory activity is also altered in malignant tumors and various body fluids of patients with cancer. Material and methods: Total cysteine endopeptidase activity and cysteine proteinase inhibitory activity were measured in homongenates of cervical lymph node tissue surgically obtained from the larynx of cancer patients. The tissue samples were histologically examined, and each was divided into two parts: positive (PCN), with mostly cancer cells, and negative (NCN) with no cancer cells. Results: In the PCNs, the levels of the assayed enzymes and their inhibitors were significantly higher than in NCNs. The mean values of cysteine proteinase activity were 2.70 ń 2.29 and 1.59 ń 1.28 for PCNs and NCNs, respectively (p 0.005). The mean values of cysteine protease inhibitors were 9.1 ń 8.6 and 6.1 ń 6.3 for PCNs and NCNs, respectively (p 0.02). An altered protease-inhibitor activity ratio was also found in PCN samples compared to NCNs. Conclusions: These data suggest increased activity of cysteine peptidases and their inhibitors in the case of secondary tumor tissue. The cancer cells metastasized to lymph node tissue produce some alteration in balance between cysteine protease activity and the endogenous inhibitors of the proteases.


    2063/2523

    Tytuł oryginału: Relationship of blood pressure measures with coronary artery calcification.
    Autorzy: Jamjoum Lama S., Bielak Lawrence F., Turner Stephen T., Sheedy II Patrick F., Boerwinkle Erick, Raghunathan Trivellore E., Peyser Patricia A.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR775-CR781, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Increased blood pressure level is a major risk factor for coronary artery disease. Previous studies of relationship of blood pressure level and hypertension status with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, were restricted to participants who were physician- or self-referred, high risk, selected on hypertension status, or young adults. Material/Methods: 803 asymptomatic individuals at least age 40 years were studied from a community. Blood pressure level was measured and blood pressure diagnostic category (i.e. hypertension vs. normotension) was determined by considering reported history of physician-diagnosed hypertension use of antihypertensive medication, and measured blood pressure levels. CAC was measured non-invasively with electron beam computed tomography. Tobit regression models allowed simultaneous modeling of presence and quantity of CAC. Results: In men, age, having ever smoked, having hypertension, LDL-C level, and body mass index were significantly and postively associated with presence and quantity of CAC. In women, age, systolic blood pressure level, use of lipid lowering medications, and waist-to-hip ratio were significantly and positively associated with presence and quantity of CAC. Relationships of measures of blood pressure with CAC were modified by age, but not other risk factors, in both sexes. Conclusions: Our results indicated that measures of blood pressure make a relatively large contribution to predictions of CAC at younger ages. CAC quantification, especially among younger individuals...


    2064/2523

    Tytuł oryginału: Role of surgery in pulmonary tuberculosis.
    Autorzy: Freixinet Jorge, Rivas Juan Jose, Castro Felipe Rodriquez de, Caminero Jose Antonio, Rodriquez Pedro, Serra Mireia, Torre Mercedes de La, Santana Norberto, Canalis Emilio
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR782-CR786, tab., bibliogr. 30 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • chirurgia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our study was to analyze current indications for surgery in tuberculosis (TB). We present our experience with TB patients presenting with indications for surgery between 1990 and 1998. Material/Methods: The indications for surgical intervention included 25 cases of pulmonary aspergilloma, 19 cases of pneumothorax, 16 cases of pulmonary nodes and masses without histological diagnosis, 15 cases of bronchiectasis, 12 cases of massive hemoptysis, 12 cases of pleural empyema, and 33 cases of other complications. No patients with multidrug-resistant tuberculosis required surgical intervention, although 56 were treated during this period. Results: The techniques utilized included lobectomy in 45 cases, pleural drainage in 32 cases, segmented pulmonary resection in 32 cases, surgical procedures on the thoracic wall in 17 cases, pneumonectomy in 10 cases, pleuropulmonary decoration in 8 cases, medaistinoscopy in 6 cases, and thoracoscopy in 5 cases. In 25 cases two or more procedures were performed on the same patient. In 36 cases (27.3 p.c.) there were complications, of which persistent air leakage after pulmonary resection was the most frequent (n=10). There was a mortality rate of 5.3 p.c. (7 cases). Conclusions: In our experience, surgery in the treatment of TB is indicated to resolve sequelae or complications, since cases of simple or multidrug-resistant TB can be managed pharmacologically. The morbidity and mortality rates in our series were acceptable.


    2065/2523

    Tytuł oryginału: Clinical outcomes and costs of Amplatzer transcatheter closure as compared with surgical closure of ostium secundum atrial septal defects.
    Autorzy: Kim Jeffrey J., Hijazi Ziyad M.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR787-CR791, tab., bibliogr. 25 poz., sum.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Transcatheter implantation of the Amplatzer surgical occluder (ASO) is an alternative to conventional surgical closure of isolated secundum atrial septal defects (ASDs). Neither the clinical outcomes nor the costs of these procedures have been extensively compared. Material and methods: We performed a retrospective cohort study to evaluate cost-effectiveness in patients with secundum ASDs who underwent closure using either placement of an ASO or surgery. We utilized available TSI accounting data to estimate hospital costs. Results: On the basis of trans-thoracic echocardiography, the procedures resulted in successful closure of the ASDs in 95.8 p.c. of patients in whom the ASO was implanted and 96.8 p.c. of surgical patients. Although there were no deaths in either group, complications occurred in 10.4 p.c. of patients in whom the ASO was implanted and 31.2 p.c. of surgical patients. The mean estimated cost per case treated with the ASO was 11,541 USD as compared with 21,780 USD for surgery. The average length of hospital stay per case treated with the ASO was 1.0 day as compared with 4.3 days for surgery. Sensitivity analyses based on our data identified no plausible situations in which the costs of surgery and of implantation of the ASO would be equal. Conclusions: The equally effective and less costly Amplatzer Septal Occlluder appears superior to surgical closure of isolated secundum ASDs in qualifying patients. The transcatheter method is also associated with significantly lower morbidity. Consequently, our results support the use of the ASO as an alternative to surgery for the management of this common congenital lesion.


    2066/2523

    Tytuł oryginału: Radioiodine-treatment (RIT) of functional thyroidal autonomy.
    Autorzy: Meller Johannes, Sahlmann C. O., Becker Wolfgang
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.1-10, il., tab., bibliogr. 72 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Since 1942, therapy with radioiodine (RIT) has gained a major role in the treatment of benign thyroid disorders, notably hyperthyroidism caused by Graves' disease or toxic multinodular goitre (thyroid autonomy). In iodine deficient areas thyroid autonomy accounts for 40-50 p.c. of all cases with hyperthyroidism. RIT has become a cost-effective first-line procedure in autonomy-patients with latent or overt hyperthyroidims, especially in the absence of a large goitre, after thyroid surgery and in elderly patients with latent or overt hyperthyroidims, especially in the absence of a large goitre, after thyroid surgery and in elderly patients with associated conditions who carry a high intra- or perioperative risk. Decisions concerning the definitive treatment of thyroid autonomy should take into account previous episodes of hyperthyroidism, objective parameters of risk stratification in euthyroid patients as well as concomitant diseases and the probability of iodine exposure in the future. In Central Europe the majority of investigators prefer to estimate the therapeutic activity individually by a radioiodine test. TCTUs (global 99m-Tc-pertechnetate thyroid uptake under suppression) - based dose concepts have been proven to be highly effective in the elimination of autonomy and carry a low ( 10 p.c.) risk of postradioiodtherapeutic hypothyriodism. Radioiodine therapy for autonomy has been found to be both effective and safe and without major early or late side effects. The most frequent complication is hypothyroidism requiring lifelong follow-up.


    2067/2523

    Tytuł oryginału: Lung perfusion scintigraphy in the diagnosis of peripheral pulmonary stenosis in patients after repair of Fallot tetralogy.
    Autorzy: Sabiniewicz Robert, Romanowicz Grzegorz, Bandurski Tomasz, Chojnicki Maciej, Aleszewicz-Baranowska Janina, Ereciński Jan, Lass Piotr
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.11-13, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: The frequency of peripheral pulmonary artery stenosis in patients after surgical repair of tetralogy of Fallot (TOF) ranges from 20 to 40 p.c. This can be either primary or secondary to the surgical intervention. The influence of resulting lung perfusion alterations on the life quality of patients is dificult to predict. The aim of this study was to compare the utility of the diagnostic procedures in this group of patients, with particular focus on lung perfusion scintigraphy. Material and methods: This study comprised 104 patients who underwent repair of TOF at ages from 5 months to 25 years. The patients have been followed up for from 4.2 to 25 years. On the basis of chest x-ray peripheral pulmonary artery stenosis was suspected in 11 patients, in 12 on the basis of echocardiography examination. Results: Lung perfusion scintigraphy has been performed on 87 patients. The disturbances in lung perfusion (mostly in the left lung) were sow by means of lung perfusion scintigraphy in 43 (49 p.c.) of patients. In 27 of them heart catheterisation has performed. Angiotraphy revealed stenosis of the lung artery branch in 15/43 (34.9 p.c.) patients with abnormal perfusion lung scan and in 4/44 (9 p.c.) in patients with normal perfusion lung scan. Intervention proceudres were carrierd out on 10 patients. Conclusions: Lung perfusion scintigraphy may prove a valuable, non-invasive screening tool in the assessment of patients after TOF repair, although both false-negative and false-postive results may happen. Therefore, it should play an auxillary role together with other diagnostic modalities.


    2068/2523

    Tytuł oryginału: Alteration of 99mTc-DMSA biodistribution in glomerulonephritis.
    Autorzy: Rajić Milena, Bogićević Momćilo, Antić Slobodan, Mitić Branka, Avramović Marina, Ilić Slobodan, Vlajković Marina, Mitić-Zlatković Marina, Stefanović Vladisav
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.15-19, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of this study was to assess the relation between 99mTc-DMSA biodistribution and its reliability as a marker of renal function in patients with glomerular kidney diseases. Material and methods: Sixty-seven patients involved in this study were classified into two group saccording to 99mTc-DTPA clearance and serum creatinine values: the 1st group consisted of 42 patients without renal failure while the 2nd group included 25 patients with renal failure. 99mTc-DMSA biodistribution was determined by measuring kidney, blood and urine activity at 2 h and 4 h. Results: The results, compared with those of 23 healhty volunteers, indicated the quantitative alteration of 99mTc-DMSA distribution in both glomerulonephritis patient groups. In reference to the control mean values of 2 h and 4 h, in patients without renal failure, kidney activity was found decreased to 52 p.c. and 57 p.c., while the blood activity increase of 37 p.c. and 44 p.c. was recorded together with the urine activity increase of 38 p.c. and 23 p.c. In patients with renal failure the alterations of renal and blood activity were more remarkable, but the urine loss was found to be unchanged. Conclusions: It is suggested that these biodistribution changes originate mainly from tubular impairment. However, in glomerulonephritis patients, altered glomerula filtration might considerably affect biodistribution of this radiopharmaceutical and limits its suitability for precise quantitative estimation of renal function.


    2069/2523

    Tytuł oryginału: Comparative diagnostic value of the breath test and the urine test with 14C-urea in the detecion of the Helicobacter pylori infection.
    Autorzy: Kopański Zbigniew, Jung Aleksandra, Wasilewska-Radwańska Marta, Kuc Tadeusz, Schlegel-Zawadzka Małgorzata, Witkowska Bożena
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.21-24, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Among 92 patients with chronic gastritis we conducted a synchronous diagnosis of the Helicobacter pylori (H. pylori) infection using a culture and a serological test (IFP), in conjunction with breath and urine tests involving 14C-urea (BTU-C14 and UTU-C14). The infection was confirmed by isolation in 71 persons (77.2 p.c.), the presence of specific IgG in the blood serum was found in 75 (81.5 p.c.). In comparison, the BTU-C14 indicated a group of 77 people (83.7 p.c.) as ifnected, and the UTU-C14 a group of 76 (82.6 p.c.). In order to determine the diagnostic value (sensitivity, specificity and efficiency) of the latter tests, the results were compared with those of the culture and of the serological tests. It was found that the BTU-C14 test used showed a 100 p.c. sensitivity, a 89.5 p.c. specificity and a 97.9 p.c. efficency. The UTU-C14 test showed a 100.0 p.c. sensitivity, a 94.4 p.c. specificity and a 98.9 p.c. efficiency in the detection of the H. pylori infection.


    2070/2523

    Tytuł oryginału: The relationship between gallbladder motility and the presence of enterogastric reflux.
    Autorzy: Artiko Vera M., Chebib Hamzeh, Petrović Nebojśa, Petrović Milorad, Peśko Predrag, Ussov Wladimir Y., Obradović Vladimir
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.25-28, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of the study was an estimation of the relation between the gallbladder (GB) motility function and the presence and quantity of enterogastric reflux (EGR). Material and methods: We investigated 172 patients: 90 with physiological GB function (filling and emptying) (FGB), 21 with impaired GB function (prolonged filling and ejection fraction 45 p.c.) and 61 with afunctional gallbladder (AGB) (without visualisation). The study was performed during 90 min (1 f/min) after i.v. application of 185 MBq 99m Tc-dietil IDA. After 30 min, a test meal was given while at the end the stomach was marked. According to the parameters from time activity curves over the stomach and hepatobiliary system, the index of EGR was calculated, while GB filling and ejection fraction were estimated from the GB time/activity curve. Results: Most frequently, EGR occurs in AGB (47.5 p.c.), followed by IGB (43 p.c.) and FGB (41 p.c.), without signficiant differences (p 0.05). The signficiantly (p 0.05) highest value of EGR was obtained in the patients with AGB in comparison to IGB and FGB. EGR values were in correlation (r = 0.168, p 0.05) with the functional status of the GB. In the patients with pathological values fo EGR ( 10 p.c.), significantly higher values (p 0.05) are obtained in AGB than in IGB and FGB. Also, these values were in correlation with the functional status of the GB (r - 0.284, p 0.05). Conclusions: We can conclude that EGR occurs more frequently in the patients with afunctional GB in comparison with those with functional and decreased motor function. Also, EGR quantity is in correlation with the impairment of the GB function.


    2071/2523

    Tytuł oryginału: Simultaneous radiotherapy and radioimmunotherapy of malignant gliomas with anti-EGFR antibody labelled with iodine 125. Preliminary results.
    Autorzy: Wygoda Zbigniew, Tarnawski Rafał, Brady Luther, Stęplewski Zenon, Bażowski Piotr, Wojtacha Maciej, Stępień Tomasz, Kula Dorota, Składowski Krzysztof, Kokocińska Danuta, Wygoda Andrzej, Pawlaczek Agnieszka, Etmańska Aleksandra, Larysz Dawid, Jarząb Barbara
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.29-33, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • radiologia
  • neurologia
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In this paper we present the preliminary results of a prospective trial of the efficacy of simultaneous radiotherapy and anti-EGFR 125I radioimmunotherapy of maligant gliomas with 2 years' total survival as the end-point, raising the question whether anti-EGFR 125I radioimmunotherapy influences the disease-fee survival in these patients. Material and methods: Patients with anaplastic astrocytoma or primary glioblastoma were previously treated by a macroscopically radical neurosurgical approach and randomized either to radiotherapy + radioimmunotherapy arm or treated by radiotherapy alone. Seven patients were included in the group with radioimmunotherapy, among them five with GBM and two with AA, and five patients in the control arm. Patients were irradiated to 60 Gy using three-dimensional conformal noncoplanar techniques. Anti-EGFR 125I monoclonal antibody 425 radioimmunotherapy (50 mCi/course) was started during 4th week of radiotherapy and was repeated three times in one week intervals. Results: Time of follow-up ranges between 2 and 10 months in the anti-EGFR 125I radioimmunotherapy arm and 4 and 9 months in the control arm. Recurrence was diagnosed in all patients in the EGFR 125I group with a lethal outcome in two of them and in 4 patients in the control group. Median time to recurrence was 2 and 5 months respectively. Conclusions: Taking into account early recurrences observed, we propose to continue the studies on the efficacy of adjuvant anti-EGFR 125I radioimmunotherapy in a selected group of patients in whom the greates benefit may be expected on the basis of molecular studies, among them EGFR expression investigation.


    2072/2523

    Tytuł oryginału: The effects of radioiodine therapy on peripheral blood lymphocyte subpopulations in patients with Graves' disease. Preliminary report.
    Autorzy: Turowska Magdalena D., Turowski Dariusz, Wysocka Jolanta, Rogowski Franciszek
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.35-38, il., bibliogr. 17 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • immunologia
  • endokrynologia
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Treatment of Graves' disease patients with radioactive iodide (131I) is becoming the standard therapy in an increasing group of cases but can induce alterations in immune response, like increasing levels of thyroid autoantibodies, and, in part, exacerbation of ophthalmopathy. The aim of this study was to assess the changes in peripheral blood (PB) lymphocyte subpopulations after 131I treatment of patients with Graves' disease. Material and methods: The study was carried out in a group of 30 patients with Graves' disease (23 f; 7 m) 49.5 ń 10.0 years of age, 26 with different subjective ocular signs like gritty sensation, increased lacrimation, orbital pain, and exophthalmos. PB lymphocyte subsets were analysed by cytofluorometry, serum concentration of TSH and fT4 were evaluated before and 6 weeks after radioiodine treatment. Results: After 131I treatment a signficant increase in CD3+, CD4+, CD3+HLA-DR+ and a decrease in CD19+ percentages of lymphocyte subsets were found in comparison with the initial evaluation. No significant changes in percentage of CD8+ and NK (CD3-CD16+ CD56+) cells were observed during this study. A significant increase in TSH and a slight decrease in fT4 concentration took place in the 6th week after 131I appliation. The patients without subjective improvement of ocular signs during the therapy initially had a percentage of CD3+, CD8+ lymphocytes which was signficantly lower compared with those with regression of ocular signs observed after 131I treatment. Conclusions: The changes in PB lymphocyte caused by 131I treatment of Graves' disease confirm the involvement of acquired cellular immunity after radiation damage of the thyroid gland...


    2073/2523

    Tytuł oryginału: E-selectin, L-selectin, ICAM-1 and IL-6 concentrations changes in the serum of patients with hyperthyroidism in the early period of radioiodine I-131 therapy.
    Autorzy: Jurgilewicz Dorota H., Rogowski Franciszek, Łebkowska Urszula, Citko Anna, Jaroszewicz Ewa, Parfieńczyk Adam
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.39-42, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • immunologia
  • radiologia
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: among cytokines-interleukins: -6 and -8 (IL-6, IL-8) and E-selectin (E-sel.), L-selectin (L-sel.) and intercellular cell adhesion molecue-1 (ICAM-1) are the most important links in the initiation of the inflammatory process. Taking into account that the inflammatory process is te basic stage of effective radioiodine therapy, we tried to compare the behaviour of the initial inflammatory factors in the early period of I-131 therapy (RAI) of hyperthyroidism. The aim of the study was to estimate the behaviour of IL-6, ICAM-1, E-selectin and L-selectin concentrations in the serum of patients with hyperthyroidims before and during I-131 therapy. Material and methods: The gorups of 26 patients with Graves' diseases (GD) and 18 patients with toxic nodula goiter (TNG), aged 34-77, were studied. Control group (C) consisted of 10 healthy volunteers. For estimation of thyroid function serum concentrations of TSH, free T4 and free T3 were measured by IRMA or RIA kits (Polatom, Poland). IL-6, ICAM-1, E-selectin and L-selectin serum concentrations were determined using ELISA method by Bender kits (USA). Blood samples for all estimations were taken 1-12 days before and in 6th week after I-131 administration. Treatment dose of radioiodine was calculated, basing on modified equation for absorbed dose. Results: Compared to control, no statistical differences in the level of E-selectin (C - 44.4 ń 11 ng/ml) and L-selectin (C - 842 ń 168.9 ng/ml) were observed before treatment in the patients with GD (E-sel. - 59.8 ń 19.6 ng/ml; L-sel-1288.2 ń 273.5 ng/ml) and with TNG (E-sel...


    2074/2523

    Tytuł oryginału: Hepatic plasma clearance of 99mTc-HEPIDA as a diagnostic tool: experimentally derived equations for a simplified determination.
    Autorzy: Surma Marian J.
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.43-48, il., bibliogr. 8 poz.
    Sygnatura GBL: 313,603

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Streszczenie angielskie: Determination of the plasma (CIpi) and specific hepatic clearance (CIhp) of 99mTc-HEPIDA is gaining acceptance as one of the best tests for the assessment of liver parenchyma functional capacity. A standard method utilises numerous blood samples, collected after injection of the radiopharmaceutical, plus collection of the urine if specific hepatic clearance is required. It is not always necessary to obtain values of the clearances by means of the laborious multi-sample procedure. In the paper there are presented formulas, based on experimental data, that form the basis of a simplified method for determination of CIpi and CIhpusing single administration of 99mTc-HEPIDA. To arrive at the value of CIpi it is sufficient to withdraw 1 blood sample in the time range of 60 to 83 min post administration of the radio-pharmaceutical. If CIhp is required, additional collection of urine over the time from 0 to 88-100 min post injection is necessary. The values of CIpi obtained by the simplified procedure are in full accordance with those obtained by the reference method utilising a series of blood samples, collected from 5 to 90 min post injection. The simplified method is sufficient as a procedure for screening of patients for liver parenchymal damage.


    2075/2523

    Tytuł oryginału: Cerebral blood flow SPECT imaging in right hemisphere-damaged patients with hemispatial neglect. A pilot study.
    Autorzy: Jodzio Krzysztof, Lass Piotr, Nyka Walenty, Gąsecki Dariusz, Bandurski Tomasz, Scheffler Justyna
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.49-51, tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hemispatial neglect is characterised as a failure by a brain-damaged patient to attend to contralesional space. It is hypothesised to be a result of damage to a network involving the frontal, parietal and cingulated cortices, basal ganglia and thalamus. Material and methods: The aim of this preliminary study was to verify this model of neglect in 22 right hemisphere-damaged acute stroke patients, using single photon emission-computed tomography (SPECT). The presence of a single rightsided vascular brain lesion was confirmed on CT and/or MRI. Hemispatial neglect, assessed with a battery of drawings, line bisection and line and shape cancellation tests, was observed in 12 cases. Results: Patients with anglect (compared with those without neglect) had more extensive hypoperfusion in the frontal and parietal cortex, as well as striatum and thalamus. Left-sided hypoperfusion in the parietal cortex and the thalamus was also significantly associated with neglect on SPECT imaging. Performance in three out of five psychological tasks commonly used to detect the presence of hemispatial neglect, such as drawing tests and line bisection test, was exclusively linked with damage to the parietal cortex of the right hemisphere, while the line cancellation test might be attributable to the lesion of the right striatum. Conclusions: These findings support the model attributing hemispatial neglect to a unilateral defect in a cortico-striatothalamo-cortical loop. CBF SPECT imaging may provide a reliable description of the brain pathology associated with hemispatial neglect.


    2076/2523

    Tytuł oryginału: An introduction to economic analysis in medicine - the basics of methodology and chosen terms. Examples of results of evaluation in nuclear medicine.
    Autorzy: Brockhuis Bogna, Lass Piotr, Popowski Piotr, Scheffler Justyna
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.55-59, tab., bibliogr. 19 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • ekonomika

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: This article overviews the basic terms and methodology approaches in economic analysis in medicine: cost-benefit analysis, cost-effectiveness analysis, cost-utility analysis and costminimisation analysis. Particular emphasis is put on nuclear medicine economic evaluation, e.g. FDG-PET studies, sestamibi breast cancer iaging and radioiodine therapy of hyperthyroidism.


    2077/2523

    Tytuł oryginału: Problem-based education of nuclear medicine technologists as part of a four-year integrated bachelor's degree in diagnostic imaging and radiation therapy in the Netherlands: report of a transition.
    Autorzy: Hoorn Willem van
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.61-64, il., tab.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Streszczenie angielskie: This article outlines the significant changes that the education of Nuclea Medicine Technologists (NMTs) in the Netherlands has witnessed in the past decade and a half. The present education is described in some detail here. The choice for the pedagogical model is motivated and some educational activities are highlighted. Some facts and figures are shown. At the end the interested reader is shown the way to some additional sources of information.


    2078/2523

    Tytuł oryginału: From teaching to self-training i.e. problem based learning.
    Autorzy: Tafil-Klawe Małgorzata
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.65
    Sygnatura GBL: 313,603

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa
  • list i notatka


    2079/2523

    Tytuł oryginału: Young patient with wrist pain.
    Autorzy: Durski Jolanta M.
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.67-68, il., bibliogr. 5 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • onkologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska


    2080/2523

    Tytuł oryginału: European School of Nuclear Medicine - 21st Seminar, April 18-19 2002, Prague, Czech Republic.
    Autorzy: Lass Piotr, Scheffler Justyna
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.69 - 21 Seminarium Europejskiej Szkoły Medycyny Nuklearnej Praga 18-19.04. 2002
    Sygnatura GBL: 313,603

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • sprawozdanie


    2081/2523

    Tytuł oryginału: Chosen abstracts of VIIIth Polish SNM Congress: [abstracts].
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.73-87
    Sygnatura GBL: 313,603

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca związana ze zjazdem
  • streszczenie

    Temat korporatywny:
  • Polskie Towarzystwo Medycyny Nuklearnej


    2082/2523

    Tytuł oryginału: Function of nociceptin and opioid OP4 receptors in the regulation of the cardiovascular system.
    Autorzy: Malinowska B., Godlewski G., Schlicker E.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.301-324, il., bibliogr. 91 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: Nociceptin is the endogenous ligand of the opioid OP4 or ORL1 (opioid receptor-like) receptor. It decreases blood pressure and heart rate in anesthetized and conscious rats and mice after its intravenous and intracerebroventricular injection in a manner sensitive to OP4 but not to OP1-3 (or ë, kappa and ć opioid) receptor antagonists. OP4 receptors involved in the cardiovascular effects of nociceptin were identified on sensory afferent fibres, in brain areas including the nucleus tratus solitarii and the rostral ventrolateral medulla, on preganglionic and/or postganglionic sympathetic and parasympathetic nerve fibres innervating blood vessels and heart or directly on these taget organs. These receptors do not seem to be tonically activated but may play a role in the pathophysiology of inflammation, arterial hypertension and cardiac or brain circulatory ischemia.


    2083/2523

    Tytuł oryginału: Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase.
    Autorzy: Slomiany B. L., Slomiany A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.325-336, il., bibliogr. 31 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Nitric oxide (NO), a pluripotent molecule, is an important biological messenger that plays a role in the regulation of tissue homeostasis and pathophysiological processes. Methods: Using sublingual salivary gland acinar cells in culture, we investigated the effect of NO on mucus glycoprotein synthesis, apoptotic processes, and the involvement of extracellular signal-regulated kinase (ERK) and p38 mitogen activated protein kinase (MAPK). Results: Exposure of the acinar cells to NO donor led to a dose-dependent decrease (up to 42.8 p.c.) in mucus glycoprotein synthesis, and this effect of NO was accompanied by a marked increase in capase-3 activity and apoptosis. Inhibition of ERK with PD98059 accelerated (up to 35.4 p.c.) the NO-induced decrease in the glycoprotein synthesis, and cause further enhancement in caspase-3 (up to 27.2 p.c.) activity and apoptosis (64.9 p.c.). On the other hand, blockade of p38 kinase with SB203580 produced a dose-dependent reversal (up to 42 p.c.) in the NO-induced reduction in the glycoprotein syntehsis, and substantially countered the NO-induced increased in capase-3 activity (by 62.8 p.c.) and apoptosis (by 57.6 p.c.). Moreover, caspase-3 inhibitor, Ac-DEVD-CHO, not only blocked the NO-induced in caspase-3 activity but also produced an increase in the glycoprotein synthesis. Conclusions: Together, our data indicate that the modulatory influence of NO on salivary mucin synthesis is closely linked to ERK and p38 protein kinase activation, in conjunction with caspase-3 activation and apoptosis.


    2084/2523

    Tytuł oryginału: Reduction of rise in blood pressure and corticol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers.
    Autorzy: Jezova D., Duncko R, Lassanova M., Kriska M., Moncek F.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.337-348, il., tab., bibliogr. 43 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The standarized extract of Ginkgo biloba (EGb 761) was found not only to improve memory and aging associated cognitive deficits but also to exert beneficial effects on mood. An antistress action of the extract has been suggested but not directly proven. The present study was aimed to evaluate the effects of EGb 761 on salivary cortisol and blood pressure response during stress in healthy young volunteers (n = 70) in a double blind placebo controlled design. A stress involving a combination of static exercise (handgrip) and mental stimuli was used. Single treatment with EGb 761 (120 mg) reduced stress-induced rise in blood pressure without affecting the heart rate. Salivary cortisol response showed differences with respect to the gender and the time of day of the stress exposure, with the activation only in male subjects in the afternoon. This activation was absent if they were treated with EGb 761. The performance in a short memory test with higher scores achieved by women remained unaffected by EGb 761 treatment. Thus, this study provides evidence that EGb 761 has an inhibitory action on blood pressure and it may influence cortisol release in response to some stress stimuli.


    2085/2523

    Tytuł oryginału: Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats.
    Autorzy: Góźdź A., Szczepańska-Sadowska E., Szczepańska K., Maśliński W., Łuszczyk B.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.349-357, il., bibliogr. 29 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Vasopressin plays significant role in regulation of blood pressure by means of V1 and V2 receptors, however regulation of synthesis of these receptors in hypertension is only poorly recognized. The purpose of the present study was to compare expression of V1a, V1b and V2 vasopressin (R) mRNA in the renal cortex, renal medulla and the heart of hypertensive renin transgenic TGR(mRen2) 27 rats (TGR) and of their parent normotensive Sprague Dawley (SD) strain. The study was performed on 12 weeks old tGR and SD rats. Competitive PCR method was used for quantitative analysis of V1a, V1b and V2 receptors mRNA in fragments of renal cortex, renal medulla and apex of the left ventricle of the heart. In both strains expression of V1aR and V2R mRNA was significantly greater in the renal medulla than in the renal cortex. In the renal medulla but not in the cortex expression of V1aRmRNA was significantly greater in TGR than in SD rats. V2R mRNA expression was similar in the renal cortex and renal medulla of both strains. V1aR mRNA was well expressed in the heart of SD and TGR rats, however there was no significant difference between these two strains. V2R mRNA was not present in the heart. V1bR mRNa could not be detected either in the kidney or in the heart. The results provide evidence for specific increase of expression of V1a receptors mRNA in the renal medulla of TGR rats.


    2086/2523

    Tytuł oryginału: Influence of the stimulation of carotid body chemoreceptors on the gastric mucosal blood flow in artificially ventilated and spontaneously breathing rats.
    Autorzy: Siński M., Kowalczyk P., Stolarczyk A., Sawionek Ł., Przybylski J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.359-369, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The cardiovascular effects of the stimulation of arterial chemoreceptors are different in spontaneously breathing and artificially ventilated animals. Respiratory failure and long term sojourn a high altitude coincide frequently of gastric ulceration. In both these situations a profound stimulation of arterial chemoreceptors is present. The purpose of the paper was to investigate the reflex effect of stimulation caroid chemoreceptors on gastric mucosal blood flow in the rat. Arterial chemoreceptors were stimulated by two methods (I) substitution gas mixture of 10 p.c. oxygen in nitrogen for room air and (II) direct injection of acid saline (0,05 ml, pH + 6.8) into the distal part of left common carotid artery. In artificially ventilated rats stimulation of arterial chemoreceptors caused significant increase in gastric mucosal vascular resistance, accompanied by marked decline in blood flow. This effect was mediated by adrenergic mechanism. On the contrary to artificially ventilated rats, decline of gastric mucosal vascular resistance with concomitant increase in blood flow was in spontaneously breathing animals. This effect was not abolished either by phentolamine or atropine. As vasodilatatory effect of arterial chemoreceptors stimulation was abolished by bilateral vagotomy, we postulate that non adrenergic and non cholinergic vagal fibers mediate observed vascular changes in gastric mucosa in spontaneously breating rats. We hypothesize that in artificially ventilated patients with respiratory failure stimulation of ...


    2087/2523

    Tytuł oryginału: Accumulation of specific ceramides in ischemic/reperfused rat heart; effect of ischemic preconditioning.
    Autorzy: Beręsewicz A., Dobrzyń A., Górski J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.371-382, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Ceramide signalling has been implicated in the mechanism of myocardial ischemia/reperfusion injury (IR). This study tested the hypothesis that ceramides containing a specific amino-linked acyl residue mediate the injury, and that ischemic preconditioning (IPC) affords myocardial protection because it prevents increased ceramide acumulation in IR myocardium. Perfused rat hearts were subjected either to the sham perfusion or to 30 min global ischemia/30 min reperfusion (IR) or were preconditioned prior to the standard IR. The ventricles were harvested for biochemical assay that involved transmethylation of ceramide amino linked acyl residues, and gas liquid chromatography measurement of acyl methyl esters. Fourteen ceramides containing myrystic, palmitic, palmitoleic, stearic, oleic, linoleic, linolenic, arachidic, arachidonic, eicosapentaenoic, behenic, docosapentaenoic, docosahexaenoic or nervonic acid were identified in the myocardium of rats. The total basal ceramide concentration in the myocardium was 135 nmol/g tissue, and it was increased by 14.1 p.c. and 48.4 p.c. in the ischemia and IR group, respectively. However, in fact, IR increased the accumulation of only 7 out of 14 ceramides identified in the heart (i.e., those containing palmitic, stearic, oleic, linoleic, and arachidonic acid), and the relative magnitude of these increases varied between the particular ceramides and was independent from their basal tissue concentration. IPC improved postichemic hemodynamic recovery and partially prevented ...


    2088/2523

    Tytuł oryginału: Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.
    Autorzy: Przegaliński E., Filip M., Papla I., Czepiel K.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.383-394, il., bibliogr. 46 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bilaterally with cannulae into the accumbens shell or core, and then were locally injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of 5-HT1B receptors). Given alone to any accumbal subregion, GR 55562 (0.1 - 10 ćg/side) or CP 93129 (0.1 - 10 ćg/side) did not change basal locomotor activity. Systemic cocaine (10 mg/kg) significantly increased the locomotor activity of rats. GR 55562 (0.1 - 10 ćg/side), administered intra-accumbens shell prior to cocaine, dose-dependently attenuated the psychostimulant-induced locomotor hyperactivity. Such attenuation was not found in animals which had been injected with GR 55562 into the accumbens core. When injected into the accumbens shell (but not the core) before cocaine, CP 93129 (0.1 - 10 ćg/side) enhanced the locomotor response to cocaine; the maximum effect being observed after 10 ćg/side of the agonist. The later enhancement was attenuated after intra-accumbens shell treatment with GR 55562 (1 ćg/side). Our findings indicate that cocaine induced hyperlocomotion is modified by 5-HT1B receptor ligands microinjected into the accumbens shell, but not core, this modification consisting in inhibitory and facilitatory effects of the 5-HT1B receptor antagonist (GR 55562) and agonist ...


    2089/2523

    Tytuł oryginału: DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex.
    Autorzy: Maćkowiak M., Chocyk A., Sanak M., Czyrak A., Fijał K., Wędzony K.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.395-407, il., bibliogr. 41 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • neurologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The hallucinogenic effect of DOI, serotonin 5-HT2A/2C receptor agonist, is knownto be associated with the activation of cortical 5-HT2 receptors. However, the effect of DOI on excitability of cortical neurons and their subsequent function is still not quite understood. Previous immunohistochemical studies using Fos proteins expression as a marker of neuronal activity showed the involvement of arachidonic acid cascade, particularly cyclooxygenase metabolic pathway, in DOI-induced Fos proteins expression in the rat parietal cortex. DOI increases arachidonic acid release which is transformed itself via acceleration of cyclooxygenase metabolic pathway to biologically active metabolities, such as prostaglandins and tromboxanes. Since cyclooxygenase-2 (COX-2) expression correlates with neuronal activity, it was of interest to investigate whether DOI is capable of influencing the level of COX-2 protein and mRNA expression in the rat parietal cortex. It was observed that neurons which were positive for 5-HT2A receptors showed constitutive COX-2 immunoreactivity. It was found further, that COX-2 protein level was increased at 1h, and returned to the control level at 3 and 6 h after DOI (5mg/kg) administration. In contrast, DOI decreased the COX-2 mRNA expression at all tested time points (1h, 3h and 6h after DOI treatment). The obtained results further support the suggestion that COX-2 activation and possibility arachidonic acid metabolites generated by COX-2 may be considered as important mediators of functional responses generated by activation of cortical 5-HT2A/2C receptors.


    2090/2523

    Tytuł oryginału: Effect of different muscle shortening velocities during prolonged incremental cycling exercise on the plasma growth hormone, insulin, glucose, glucagon, cortisol, leptin and lactate concentrations.
    Autorzy: Żołądź J. A., Duda K., Konturek S[tanisław] J., Śliwowski Z., Pawlik T., Majerczak J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.409-422, il., bibliogr. 33 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: Strenuous exercise was reported to involve the alteration in the release of some "stress" hormones such as growth hormone (GH), cortisol, catecholamines and appropriate adjustment of energy metabolism but the relative contribution of these hormones to metabolic response, to cycling exercise performed at different muscle shortening velocities, has not been clarified. Aims: The purpose of this experimet was to assess the effect of applying different pedalling rates during a prolonged incremental cycling exercise test on the changes in the plasma levels of growth hormone, cortisol, insulin, glucagon and leptin in humans. Material and methods: Fifteen healthy non-smoking men (means ń SD: age 22.9 ń 2.4 years; body mass 71.9 ń 8.2 kg; height 178 ń 6 cm; with VO2max of 3.896 ń 0.544 1 min**-1), assessed in laboratory tests, were subjects in this study. The subjects performed in two different days a prolonged incremental exercise tests at two different pedalling rates, one of them at 60 and another at 120 rev min**-1. During this tests the power output has increased by 30 W every 6 minutes. The tests were stopped when the subject reached about 70 p.c. ogf the VO2max. Results and conclusions: We have found that choosing slow or fast pedaliing rates (60 or 120 rey min **1), while generating the same external mechanical power output, had no effect on the pattern of changes in plasma cortisol, insulin, glucagon glucose and leptin concentrations. But, generation of the same external mechanical power output at ...


    2091/2523

    Tytuł oryginału: Vasopressin and oxytocin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats.
    Autorzy: Ciosek J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.423-437, il., tab., bibliogr. 60 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Since the thyrotropin-releasing hormone (tRH) can modulate the processes of vasopressin (AVP) and oxytocin (OT) biosynthesis and release mainly at the hypothalamo-neurohypophysial level, the present experiments were undertaken to estimate whether TRH, administered intravenously in differenet doses, modifies these mechanisms under conditions of osmotic stimulation, brought about by dehydration. AVP and OT contents in the hypothalamus and neurohypophysis as well as plasma levels of AVP, OT, free thyroxine (FT4) and free triiodothyronine (FT3) were studied after intravenously TRH treatment in euhydrated and dehydrated for two days male rats . Under conditions of equilibrated water metabolism TRH diminished significantly the hypothalamic and neurohypophysical AVP and OT content but was without the effect on plasma oxytocin level; however, TRH in a dose of 100 ng/100 g b. w. raised plasma AVP level. TRH, injected i.v. to dehydrated animals, resulted in a diminution of AVP content in the hypothalamus but did not effect the hypothalamic OT stores. After osmotic stimulation, neurohypophysial AVP and OT release was significantly restricted in TRH-treated rats. Under the same conditions, injections of TRH were followed by a significant decrease of plasma OT level. I. v. injected TRH enhanced somewhat FT3 concentration in blood plasma of euhydrated animals but diminished FT4 plasma level during dehydration. Data from the present study suggest that TRH displays different character of action on vasopressin and oxytocin secretion in relation to the actual state of water metabolism.


    2092/2523

    Tytuł oryginału: Effect of constitutive- and inducible-cyclooxygenase in the carbachol-induced pituitary-adrenocortical response during social stress.
    Autorzy: Bugajski J., Gądek-Michalska A., Bugajski A. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.453-462, il., bibliogr. 24 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Acetylcholine potently stimulates the hypothalamic-pituitary-adrenal (HPA) axis. Cholinergic receptor agonist carbachol, given intraperitoneally (i.p.) or into the lateral cerebral ventricle (i.c.v.) to non-anesthetized racts via multiple pathways to stimulate the HPA axis. The present study sought to determine 1) the functional selectivity of carbachol for cholinergic muscarinic and/or nicotinic receptors involved in the stimulation of HPA axis; 2) the involvement to prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH and corticosterone secretion in non-stressed rats and animals exposed to social crowding stress for 7 days (24 per a cage for 6). Carbachol was given i.c.v. or i.p and cholinergic receptor antagonists or cyclooxygenase isoenzyme antagonists were given by the same routes 15 min earlier. One hour after the last injection trunk blood was taken for ACTH and corticosterone determinations. Atropine (0.1 ćg i.c.v.), a cholinergic receptor antagonist , totally abolished the carbachol (2 ćg i.c.v.) - induced ACTH and corticosterone secretion and mecamylamine (20 ćg i.c.v.), a selectiove nicotinic receptor antagonist, did not affect this secretion. This finding indicates that carbachol functions as a selective central cholinergic muscarinic receptor agonist for the HPA axis stimulation. Crowding stress significantly diminished the carbachol (0.2 mg/kg i.p.)-induced plasma ACTH and corticosterone levels measured 1 hr after administration. ...


    2093/2523

    Tytuł oryginału: Obituary. Professor Dennis V. Parke. Member of the Editorial Advisory Board.
    Autorzy: Piotrowski Jerzy K.
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.[85-87], il.
    Sygnatura GBL: 306,438

    Typ dokumentu:
  • praca biograficzna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • historia nowożytna
  • historia XX wieku

    Temat osobowy:
  • Parke
  • Dennis V. 1922-2002


    2094/2523

    Tytuł oryginału: Markers of oxidative damage - applicability and limitations.
    Tytuł polski: Markery uszkodzeń oksydacyjnych - zastosowanie i ograniczenia.
    Autorzy: Jodynis-Liebert Jadwiga
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.89-109, il., bibliogr. 161 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie polskie: Źródłem wolnych rodników w ustroju są reakcje enzymatyczne, organelle komórkowe, neutrofile i makrofagi a także czynniki zewnętrzne: promieniowanie jonizujące i niektóre ksenobiotyki. Powstałe wolne rodniki mogą reagować ze wszystkimi makrocząsteczkami komórki powodując jej uszkodzenie lub śmierć. Wskaźniki uszkodzeń oksydacyjnych są niezbędne w badaniach udziału tych uszkodzeń w patogenezie wielu chorób, w określaniu mechanizmu toksyczności ksenobiotyków a także w ocenie skuteczności terapii antyoksydacyjnej. Praca zawiera przegląd danych dotyczących przydatności oznaczania trzech głównych grup biomarkerów - produktów powstających z uszkodzonych lipidów, białek i DNA. Ze względu na fakt, że peroksydacja lipidów jest najszerzej badanym procesem indukowanym przez wolne rodniki, temu zagadnieniu poświęcono najwięcej miejsca omawiając oznaczanie koniugatów dienowych, substancji reagujących z kwasem tiobarbiturowym, alkanów w powietrzu wydychanym, aldehydów oraz izoprostanów. Przedstawiono także przegląd sposobów oznaczania produktów utleniania białek powstających w procesach lipoksydacji a przede wszystkim najbardziej popularnego markera - związków karbonylowych. Najczęściej stosowanym wskaźnikiem uszkodzenia DNA jest 8-hydroksydeoksyguanozyna, chociaż ostatnio badacze proponują oznaczanie produktów utleniania innych zasad np. cytozyny i adeniny a także tzw. etenoadduktów DNA powstających w wyniku reakcji DNA z hydroksyaldehydami.

    Streszczenie angielskie: Free radicals generated by enzymatic sources, subcellular organelles and toxic substances can react with all cellular macromolecules and lead to cell death and tissue injury. There is a great need for markers of radical damage which can be used to monitor the involvement of such a damage in the pathogenesis of diseases or in the toxicity of xenobiotics. The purpose of this review is to provide information regarding the utility of the determination of three main groups of biomarkers - the products resulting from free radical damage to lipids, proteins and DNA.


    2095/2523

    Tytuł oryginału: Ischemia-reperfusion of the liver impairs the inducibility of microsomal cytochrome P450 system by phenobarbital in rats.
    Tytuł polski: Niedokrwienie i reperfuzja wątroby szczurów zaburza indukcję mikrosomalnego systemu cytochromu P450 przez fenobarbital.
    Autorzy: Wiaderkiewicz Ryszard, Wiaderkiewicz Anna, Czekaj Piotr, Lebda-Wyborny Tomasz, Kaszuba Michał
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.111-122, il., tab., bibliogr. 26 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Stosując zwierzęcy model ciepłego niedokrwienia i reperfuzji wątroby (szczury szczepu Spraque-Dowley) wykazaliśmy, że w wyniku niedokrwienia/reperfuzji zaburzone zostają podstawowe procesy metaboliczne przebiegające w hepatocytach, w tym również ich potencjał biotransformacyjno/detoksacyjny zależny od aktywności cytochromu P450. 24-godzinna reperfuzja skutkowała znacznym spadkiem całkowitej zawartości cytochromu P450, cytochromu b5 jak również obniżeniem aktywności współpracujących z nimi oksydoreduktaz NADPH i NADH. Ekspresja białka izoform CYP1A1, CYP2B1/B2 i CYP2E1 ulegała po reperfuzji obniżeniu o 30 proc. zaś odpowiadające im aktywności enzymatyczne (EROD, PROD, MROD) o 50-70 proc. Reperfuzja w znacznym stopniu zmniejszała również podatność cytochromu P450 na indukcję przez fenobarbital. W wyniku stymulacji fenobarbitalem w trakcie reperfuzji ekspresja białka izoformy CYP2B1/B2 była 3-krotnie niższa, zaś odpowiadająca jej aktywność PROD nawet 8-krotnie niższa niż w odpowiedniej grupie, która nie była poddana zabiegowi niedokrwienia/reperfuzji. Chociaż mechanizmy prowadzące do obserwowanego ograniczenia aktywności i indukcyjności poszczególnych izoform cytochromu P450 nie są ostatecznie poznane należy się liczyć z faktem, że w wyniku niedokrwienia i reperfuzji wątroby procesy biotransformacji/detoksykacji ksenobiotyków metabolizowanych z udziałem cytochromu P450 mogą być istotnie ograniczone.

    Streszczenie angielskie: Using the animal model of warm ischemia and reperfusion of the liver (male Spraque-Dawley rats) we have shown that during reperfusion the cytochrome P450 system in the rat liver is seriously impaired. Protein expression of CYP1A1, CYP2B1/B2 and CYP2E1 after 24 h of reperfusion was reduced by 30 p.c. and their corresponding enzymatic activities (EROD, PROD, MROD) dropped by 50-70 p.c. After simulation with phenobarbital during reperfusion the expression of CYP2B1/B2 protein was 3 times lower, and their enzymatic PROD activity even 8 times lower, than in the corresponding group not subjected to ischemia/reperfusion. The results indicate that during ischemia and reperfusion detoxification of many xenobiotics that depend on the cytochrome P450 metabolism may be affected.


    2096/2523

    Tytuł oryginału: Effects of lead exposure on fenitrothion-induced adrenocortical stimulation in rats.
    Tytuł polski: Wpływ ołowiu na zmiany wskaźników aktywności kory nadnerczy u szczurów zatrutych fenitrotionem.
    Autorzy: Osicka-Koprowska Anna, Szutowski Mirosław M.
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.123-130, tab., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Badano wpływ ołowiu na poziom kortykosteronu w osoczu i zawartość kwasu askorbinowego w nadnerczach szczurów zatruwanych fenitrotionem. Badania przeprowadzono w różnych warunkach narażenia na obydwa ksenobiotyki. W pierwszym eksperymencie szczurom wstępnie narażonym na ołów (200 ppm w wodzie do picia przez dwa tygodnie) podawano pojedynczą dawkę fenitrotionu, 20 proc. lub 10 proc. LD50. W drugim eksperymencie szczury eksponowano równocześnie na ołów (200 ppm z wodą do picia) i fenitrotion (1 proc. LD50) przez dwa i sześć tygodni. Stężenie kortykosteronu w osoczu i zawartość kwasu askorbinowego w nadnerczach oznaczano w przedziałach czasowych 2 h - 24 h po podaniu dawki fenitrotionu w eksperymencie pierwszym i po 2 i 6 tyugodniach w eksperymencie drugim. Kortykosteron oznaczano zmodyfikowaną fluorymetryczną metodą Guillemina [16], kwas askorbinowy - kolorymetryczną metodą Schafferta i Kingsleya [17]. Wyniki pracy wskazują, że wpływ ołowiu na zmiany badanych parametrów wywołane fenitrotionem zależą od warunków eksperymentu. Wstępne narażenie na ołów spowodowało zmniejszenie efektu obserwowanego po zatruciu fenitrotionem. W warunkch równoczesnego narażenia na niskie dawki obydwu ksenobiotyków wystąpiło działanie addycyjne.

    Streszczenie angielskie: Plasma corticosterone level and adrenal ascorbic acid concentration were determined in rats to asses the influence of lead exposure on fenitrothioninduced elevation of hormone concentration. The experiment was performed on rats exposed to lead (200 ppm in water for two or six weeks) and fenitrothion, administered simultaneously (dose 1 p.c. LD50 per day for six weeks) or sequentially (single dose 20 p.c. or 10 p.c. LD50). In sequential intoxication, the effect of fenitrothion in rats pretreated with lead was diminished. Contrary to this, in simultaneous intoxication, the additive effect was observed.


    2097/2523

    Tytuł oryginału: Case study: distribution and redistribution of verapamil and its metabilite in fatal poisoning.
    Tytuł polski: Dystrubucja i redystrybucja werapamilu i jego metabolitu w zatruciu śmiertelnym.
    Autorzy: Kłys Małgorzata, Bujak-Giżycka Beata, Woźniak Krzysztof, Bystrowska Beata
    Źródło: Acta Pol. Toxicol. 2002: 10 (2) s.131-142, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 306,438

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Praca dotyczy zatrucia werapamilem. Badanie toksykologiczne przeprowadzone z zastosowaniem chromatografii cieczowej z detekcją masową (LC/MS) ujawniło werapamil i jego metabolity w materiale sekcyjnym. Analiza ilościowa werapamilu i jego głównego metabolitu norwerapamilu we krwi obwodowej, pobranej dwukrotnie jeszcze przed sekcja wykazała nieznaczne różnice w zawartości tych związków, w wyniku procesów mających miejsce w okresie pośmiertnym (przed autopsją). Procesy te dyskutowane są w pracy w świetle problemów redystrybucji pośmiertnej oraz przydatności otrzymanych wyników dla orzecznictwa sądowo-lekarskiego.

    Streszczenie angielskie: This paper refers to a case of self-poisoning with verapamil. The toxicological investigation carried out by means of liquid chromatography with mass spectrometric detection (LC/MS) revealed verapamil and its metabolites in postmorten specimens. Quantitative determination of verapamil and its major metabolite norverapamil in pre-autopsy material (peripheral venous blood) showed changes in concentrations of these xenobiotics that take place in the body during the postmortem interval. The significance of the concentration level of verapamil and norverapamil in post-mortem pre-autopsy and autopsy material is discussed in the light of redistribution problems and usefulness of the results for forensic toxicology practice.


    2098/2523

    Tytuł oryginału: A simple and rapid liquid chromatographic method for the determination of metronidazole and its hydroxymetabolite in plasma and cutaneous microdialysates.
    Autorzy: Klimowicz Adam, Bielecka-Grzela Stanisława, Tomaszewska Urszula
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.327-331, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A rapid, accurate, simple and low-cost method for quantitative determination of metronidazole and its hydroxymetabolite, in plasma and microdialysate samples, using tinidazole as internal standard, has been developed. Metronidazole is widely used as a valuable agent for antiprotozoal as well as antibiotic therapy when anaerobic organisms are involved. Separation of the compounds studied was performed on a 120X4 mm analytical column, filled with LiChrosorb RP-8, 5 ćm, the mobile phase consisted of 0.05 mol/L aqueous solution of potassium dihydrogen phosphate, adjusted to pH=3.5 with orthophosphoric acid, methanol and acetonitrile (40:22:3, v/v/v). Detection was performed at 320 nm. Intra- and interserial precision was below 4,6 p.c. and 7.9 p.c., respectively, for both the compounds studied. The presented method is suitable for pharmacokinetic studies.


    2099/2523

    Tytuł oryginału: Determination of 2,6-dimethylaniline and o-toluidine impurities in preparations for local anaesthesia by the HPLC method with amperometric detection.
    Autorzy: Baczyński Emil, Piwońska Agata, Fijałek Zbigniew
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.333-339, il., bibliogr. 21 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: 2,6-Dimethylaniline (2,6-DMA) and o-toluidine (o-TLD) together with their decomposition products are potential technological impurities of Pharmaceuticals used for local anaesthesia, in which lidocaine and prilocaine appear as active substances. Pharmacopoeial analytical methods for the determination of these impurities are little sensitive (from about 1 ćg ml**-1) and accurate and provide results which are difficult to interpret. Taking the above into account, a sensitive and specific amperometric method has been developed, which enables, after separation with the use of HPLC, an accurate determination of the content of 2,6-DMA and o-TLD in various pharmaceutical preparations. The determinations were performed at a glassy carbon electrode at a potential of +0.85 V. The limit of detection for both 2,6-DMA and o-TLD was 0.8 ng ml**-1. On the other hand, the limit of quantitation, considering a signal to noise ratio, was 1.5 ng ml**-1. The developed method allows to determine low concentrations of the impurities in question, which are hardly 1/120000 of the main substance. Preparation and determination of samples is carried out in a relatively short time, thus the method can be applied to routine investigations. Statistical evaluation of the obtained results shows that the accuracy and precision of the elaborated HPLC-ED method is good.


    2100/2523

    Tytuł oryginału: Lipophilicity parameter from high-performance liquid chromatography on an immobilized artificial membrane column and its relationships to bioactivity of the group of 2,4-dihydroxythiobenzanilides.
    Autorzy: Jóźwiak Krzysztof, Szumiło Halina, Senczyna Bogusław
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.341-346, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Several groups of 2,4-dihydroxythiobenzanilide derivatives are extensively studied in our laboratories as potential antifungal or antibacterial agents. Previous papers showed that their biological activities are closely correlated with the lipophilicity determined in HPLC experiments using on octadecylsilyl stationary phase (RP-18). In the present paper we attempted to measure chromatographic incides of 2,4-dihydroxythiobenzanilides, using a silica-based immobilized artificial membrane (IAM) column especially designed to evaluating biological lipophilicity. The theoretical (extrapolated) retention in pure water the log kw(IAM) parameter for 23 derivatives was determined during poly-cratic experiments. Statistical analysis exhibited good correlations between the log kw(IAM) parameter and the biological data concerning bacteriostatic activity of these compounds. Retention on the IAM phase can be used as predictor of biological membrane permeability and biological lipophilicity of 2,4-dihydroxythiobenzanilides in spite of the acidic properties of this group of compounds.


    2101/2523

    Tytuł oryginału: Investigation of physical and hypoglycaemic properties of rectal suppositories with chosen insulin.
    Autorzy: Kosior Anna
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.353-358, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Rectal suppositories with insulin Humulin M3 (30/70) were prepared. Witepsol H15 and a polyoxyethyleneglycol mixture, composed of PEG 400, PEG 1000 and PEG 6000, were used as base. Tween 60 and sodium salicylate were used as auxiliary substances. Hypoglycaemic properties of the prepared suppositories were tested on rabbits. The obtained results were compared with the data acquired after intravenous administration of insulin and subcutaneous injection of insulin.


    2102/2523

    Tytuł oryginału: Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions.
    Autorzy: Piotrowska Karolina, Hermann Tadeusz W., Augustyniak Włodzimierz
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.359-364, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Papaverine hydrochloride, papaverinol, and papaveraldine chloroform solutions were exposed to UV light of 254 nm in atmospheric, aerobic and anaerobic (helium) conditions. The same degradation products appear (TLC) in the above papaverine hydrochloride chloroform solutions. However, the rate of papaverine hydrochloride degradation processes is enhanced as a function of oxygen pressure. Papaverinol and papaveraldine photooxidation products are essentially not different from those observed in the above papaverine chydrochloride solutions. However, the amount of an unknown brown degradation product (X) is the greatest in the papaverinol chloroform solution degraded. That brown compound was previously observed in papaverine either hydrochloride or sulfate injection solutions on their storage even when protected from daylight. The preliminary X product structure development was undertaken (TLC, molecular weight, elemental analysis, UV/VIS, IR and C MAS NMR spectroscopy).


    2103/2523

    Tytuł oryginału: A study on organic nitrates. P. 6: Synthesis and pharmacological activity of 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate.
    Autorzy: Korzycka Lucyna, Owczarek Jacek, Czarnecka Elżbieta
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.365-369, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Basing on the studies on the relationship between the structure and activity, we have synthesized a nitrate analogue of propranolol as potential donor of nitric oxide. The obtained 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate decreases blood pressure more than propranolol and slows the heart rate less than propranolol. It also affects peripheral vascular resistance less than propranolol.


    2104/2523

    Tytuł oryginału: Search for new non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-1 RT).
    Autorzy: Brzezińska Elżbieta, Glinka Ryszard
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.379-392, il., bibliogr. 14 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The derivatives of dibenzoxazocinone, dibenzoxadiazocine, dibenzoxadiazonine and benzodiazepine systems were synthesized as potential lead compounds for inhibitors of HIV-1 reverse transcriptase. The suggested structures were derived from analysis of the described spatial and physicochemical requirements for HIV-1 RT inhibitors. All of the evaluated compounds (apart from the oxadiazocine derivatives) showed a week inhibitory activity on recombinant HIV-1 RT from Escherichia coli.


    2105/2523

    Tytuł oryginału: Synthesis and pharmacological properties of sulfur derivatives of indane-1,3-dione.
    Autorzy: Mitka Katarzyna, Kowalski Piotr, Sułko Jerzy, Woźniak Marian, Kloc Jowita, Chodkowska Anna, Jagiełło-Wójtowicz Ewa
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.387-393, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • neurologia
  • farmacja
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Synthesis of sulfur derivatives of indane-1,3-dione, VIIb-c, VIIIa-b, IX and X is described. Results of a preliminary pharmacological screening of six compounds [VIIb, VIII, VIIIb, IX, X and XI]are presented.


    2106/2523

    Tytuł oryginału: Estimation of humoral activity of eleutherococcus senticosus.
    Autorzy: Drozd Janina, Sawicka Teresa, Prosińska Joanna
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.395-401, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: The aim of the present work was an estimation of the influence of two plant pharmaceutical preparations containing an extract from the root of Eleutherococcus senticosus: Argoeleuter tablets and Immuplant tablets, on the humoral response of immunological system. Experiments were performed with female Balb/c mice six weeks old. In order to reveal the influence of taking preparations, containing an extract from Eleutherococcus senticosus on some elements of the immunological system, three ways of their administration have been compared: before illness, during illness and a combination of both. The obtained results allow formulating the following conclusions: -the pharamceutical preparations, containing the extract from Eleutherococcus senticosus administered orally, influence on the increase of the level of immunoglobulins comprised in the mice's blood serum, -the pharmaceutical preparations act with different power, not fully dependent on the content of marker of the active substance - eleutheroside E, -dosage of the preparations containing the extract from Eleutherococcus senticosus should not be estabilished basing only on the extract content, -best curative results, measured as the stimulation of humoral response of the organism were obtained when a given preparation was administered therapeutically, even though the combined administration - prophylactically with prolonged administration during illness also is correct.


    2107/2523

    Tytuł oryginału: Truxillic and truxinic acids-occurrence in plant kingdom.
    Autorzy: Krauze-Baranowska Mirosława
    Źródło: Acta Pol. Pharm. 2002: 59 (5) s.403-410, il., bibliogr. 56 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: For some years now there has been a systematic increase in the number of reports on new secondary metabolites of truxillic and truxinic acid derivatives. The paper offers a presentation of existing forms of cyclobutanodicarboxylic acids in plant kingdom, while considering their stereochemical structure and biosynthesis. Also presented are some results of research on the pharmacological activity of synthetic and natural derivatives of these compounds. The paper shows additionally the results of search in nature for compounds containing fragments of truxinic acids seen against the occurrence of other compounds of cyclobutane derivatives in plant kingdom.


    2108/2523

    Tytuł oryginału: Morphological evaluation of the pancreas in rats with fluoride - induced hyperglycemia.
    Autorzy: Stawiarska-Pięta Barbara, Szaflarska-Stojko Ewa, Grążewska-Starak Joanna, Grucka-Mamczar Ewa
    Źródło: Ann. Acad. Med. Siles. 2002: 52/53 s.35-40, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,709

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta


    2109/2523

    Tytuł oryginału: Genetic basis of neural tube defects. [P.] 1: Regulatory genes for the neurulation process.
    Autorzy: Gos Monika, Szpecht-Potocka Agnieszka
    Źródło: J. Appl. Genet. 2002: 43 (3) s.343-350, il., bibliogr. [17] poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Neural tube defects (NTD) together with cardiovascular system defects are the most common malformations in the Polish population (2.05-2.68/1000 newborns). They arise during early embruogeneses and are caused by an improper neural groove closure during the neurulation process. NTD can arise from the influence of specific environemntal factors on the foetus. The genetic factor is also very important, because NTDs have multigenetic conditioning. It was sugegsted that genes connected with the regulation of neurulation could also be involved in NTD aetiology, especilly when their deletion or modification leads to neural tube defects uin the mouse model. Examles are genes from the PAX family, T (Brachyury), BRCA1 and PDGFRA genes.


    2110/2523

    Tytuł oryginału: Documenting ancient DNA quality via alpha satellite amplification and assessment of clone sequence diversity.
    Autorzy: Pusch Carsten M., Kayademir Tuncay, Prangenberg Kurt, Conrad Nicholas J., Czarnetzki Alfred, Blin Nikolaus
    Źródło: J. Appl. Genet. 2002: 43 (3) s.351-364, il., tab., bibliogr. s. 362-364
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • historia starożytności

    Streszczenie angielskie: C/G- T/A nucleotide alterations have been shown to hamper the straightforward interpretation of mitochondrial DNA sequence data derived from ancint tissues. Attempting to characterise this finding with respect to nuclear DNA, we contrasted two estabilished protocols: (i) an enzymatic reppair of damaged DNA, thereby translating and closing nicks in the DNA, and (ii) the application of N-phenacylthiazolium bromide, which cleaves glucose-derived protein crosslinks, presumably derived from Maillard reactions. We used medieval human bones that were refractory to standard PCR procedures. Due to negligible presence of short tandem repeat loci adn also mitochondrial sequences, the extracted ancient DNA needed a higher copy PCR system to yield amplification products. The chosen PCR target was specific alphoid repetitive DNA with an experimentally determined minimum of 1000 copies per haploidgenome. Alphoid repeat segments were generated from both contemporary DNA and dNA extracts of two human skeletons dating from 450-600 AD (omitting uracil N-glycocylase pre-treatment of the extracted samples), and were subsequently cloned and sequenced. The sequences were evaluated for the number type of nucleotide alternations noted after the different pre-treatments, and were compared to our alphoid consensuses sequence generated from modern DNA. Both methods failed to reflect the expected 32 p.c. variability among single alphoid repeats (accounting for locus-specific differences and polymerase errors) as well as to display the actual 2.88 ratio of ...


    2111/2523

    Tytuł oryginału: Direct sequencing of PCR products for mutation detection in osteogenesis imperfecta.
    Autorzy: Galicka Anna, Gindzieński Andrzej
    Źródło: J. Appl. Genet. 2002: 43 (3) s.365-369, il., tab., bibliogr. [7] poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka
  • traumatologia i ortopedia

    Typ dokumentu:
  • komunikat
  • tytuł obcojęzyczny

    Streszczenie angielskie: This work present a short and simple method for mutation detection in type I collagen genes, based on the direct sequencing of single-stranded DNA. The sequencing of type I collagen genes is complicated and difficult because of their large size and highly repertitive and GC-rich coding regions. Although many techniques have been developed for mutation screening in osteogenesis imperfecta (OI), they represent differentdegrees of sensivity and are difficult to reproduce and too expensive for aplication in each laboratory. The method described here is short, easy and especially useful for sequencing of collagen genes in OI cases, in which the region with a suspected structurl defect is localized by collagen analysis.


    2112/2523

    Tytuł oryginału: Differences between rats and mice in induction of 4S á-naphthoflavone-binding protein expression by treatment with á-naphthoflavone.
    Autorzy: Brauze Damian, Januchowski Radosław, Szyfter Krzysztof
    Źródło: J. Appl. Genet. 2002: 43 (3) s.371-376, il., tab., bibliogr. [16] poz.
    Sygnatura GBL: 305,055

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Sprague-Dawley rats and several inbred strains of mice were compared with respect to the induction of 4S á-naphthoflavone-binding protein expression by treatment with á-naphthoflavone (BNF), an aryl hydrocarbon receptor (AhR) ligand. Inbred strains of mice chosen for the study encompassed 3 allelic forms of AhR found in Mus musculus so far. As it was reported by us earlier, treating rats with BNF caused a significant induction of BNF-binding protein expression. By contrast, no BNF-binding protein was detected in mice treated with BNF in corn oil as a vehicle or with corn oil itself.


    2113/2523

    Tytuł oryginału: Monte Carlo simulation of genome viability with paralog replacement.
    Autorzy: Cebrat Stanisław, Stauffer Dietrich
    Źródło: J. Appl. Genet. 2002: 43 (3) s.391-395, tab., bibliogr. [14] poz.
    Sygnatura GBL: 305,055

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: Recent analyses of genome content have revealed that many single functions, even in haploid organisms, can be executed by more than one gene. As a result, experimental disruption of many individual genes does not exert lethal effects on the organism or even any visible change in the phenotype of the organism with a knockedout gene. Our analysis shows that such genetic redundancy allows for an appreciably higher mutation load in the genome simulations before the viability of the whole organism is destroyed.


    2114/2523

    Tytuł oryginału: Global initiative for asthma 2002 - what concerns occupational medicine.
    Autorzy: Górski Paweł
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.207-208
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2115/2523

    Tytuł oryginału: Gene p53 mutations, protein p53, and anti-p53 antibodies as biomarkers of cancer process.
    Autorzy: Lutz Waldemar, Nowakowska-Świrta Ewa
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.209-218, il., tab., bibliogr. 51 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • genetyka
  • immunologia
  • onkologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The finding that gene mutations and changes in their expression form the basis of cancer processes, has prompted molecular epidemiologists to use biomarkers for detecting damaged genes or proteins synthesized under their control in easily available cellular material or systemic liquids. Mutations in the suppressor gen p53 are thought to be essential for cancer development. This gen is one of the most important regulators of transcription, cellular cycle. DNA repair and apoptosis detected till now. Inactivation of gene p53 leads to uncontrolled cell divisions, and further to transformation of normal cells into the carcinous ones. Observations that mutations in gene p53 appear under conditions of occupational and environmental exposures to chemical and physical carcinogens, such as vinyl chloride, radon, or aflatoxin B1, have proved to be of enormous importance for the occupational and environmental health. Changes in expression of gene p53, and also its mutations, cause variations of cellular protein p53 concentration. Higher cellular protein p53 levels are associated with increased protein transfer to the extracellular liquid and to blood. It has been observed that increased blood serum protein p53 concentrations may have a prognostic value in early diagnosis of lung cancer. The results of a number of studies confirm that accumulation of a mutated form of protein p53, and presumably also large quantities of wild forms of that protein in the cells, may be a factor that triggers the production of anti-p53 antibodies...


    2116/2523

    Tytuł oryginału: Roles of nitric oxide in carcinogenesis. Protumorigenic effects.
    Autorzy: Stępnik Maciej
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.219-227, bibliogr. 69 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie angielskie: Nitric oxide (NO) is a small gaseous molecule involved in many physiological and pathophysiological processes in the human organism. Reports published so far indicate its multiple and not fully understood role in tumor initiation and progression. The paper reviews basic mechanisms of protumorigenic effects of NO: genotoxicity and mutagenicity, the results of the studies on nitric oxide synthases activity and expression in human tumors of different origin, as well as the main mechanisma of NO-mediated processes responsible for tumor progression (tumor cell growth, angiogenesis, invasiveness and metastatic activity). Because the effects of NO in cancer development are not clearly defined after the revire of protumorigenic effects, some data, which indicate the antitumorigenic effects of NO are also presented.


    2117/2523

    Tytuł oryginału: Behavioral sensitivity to amphetamine after repeated exposure to an organophosphorous pesticide in the rat. Effect of coexposure to restraint.
    Autorzy: Gralewicz Sławomir, Wiaderna Dorota, Lutz Piotr
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.229-238, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: In the work environment, chemical stressors coexists frequently with physical or psychological stressors. The purpose of the present experiment was to find out whether the effects of a repeated exposure to chlorphenvinphos (CVP), an organophosphorus pesticide, could be modified by a concurrent exposure to restraint, a psychological stressor. The experiment was performed on male Wistar rats. CVP was administered ten times (one injection/day) at doses of 0.5 or 1.0 mg/kg i.p. (1/20 and 1/10 of LD50, respectively) within a period of two weeks. A half of the rats from each group were immobilized in restraint chambers for 120 min/day starting 10-15 min after CVP injection. In each rat, the effect of 0.5 mg/kg of amphetamine (AMPH) and 0.75 mg/kg of scopolamine (SCOP) on motor activity in an open-field was tested three weeks or six weeks (in rats exposed to 0.5 mg/kg or 1.0 mg/kg doses of CVP, respectively) after the last exposure day. No clear cut effect on the behavioral responsiveness to AMPH or SCOP were noted in rats subjected to repeated restraint, repeated 0.5 mg/kg doses of CVP, or combination of these two stressors. In rats exposed to CVP at the 1.0 mg/kg doses, the behawioral response to AMPH was augmented and this effect was not apparently altered in rats coexposed to restraint. The above result indicates that the repeated exposure to CVP may lead to functional alterations within the central nervous system and that coexposure to restraint neither facilitates nor prevents these alterations from development.


    2118/2523

    Tytuł oryginału: Firefighting efforts may lead to massive fungal growth and exposure within one week. A case report.
    Autorzy: Rautiala Sirpa H., Nevalainen Aino I., Kalliokoski Pentti J.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.303-308, tab., bibliogr. 23 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • ochrona środowiska
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: A case study on extensive fungal growth that occurred in an apartment building after firefighting efforts is described in this paper. Exposure to airborne microorganisms (both viable and total) was investigated filter sampling in three periods before and during remedial actions after the fire. Material samples were also analyzed. Extensive mold growth was observed on the building materials as soon as eight days after the fire. High concentrations of fungal spores, 10**7 cfu/g, were found when material samples were analyzed. Concentrations of airborne fungal spores (10**4 spores/m3) were also high and increased by two orders of magnitude during the demolition of moldy building materials and during the clean-up after the demolition. The proportions of airborne viable fungi in comparison with the total spore concentrations were 28-83 p.c. immediately after the fire, but they had decreased to 1 p.c. two months after the fire during the reconstruction phase. Paecilomyces was the main fungal genus in the indoor air before and during the demolition, while Penicillium dominated during the reconstruction. Paecilomyces was not detected in the outdoor air. Paecilomyces and Penicillium were also found in the material samples. The results show that fast and extensive mold growth in a building may take place also in subarctic climates, at least during summer. High concentrations of fungal spores are released to the air during the demolition of moldy building materials and the following clean-up. Therefore, personal protection is necessary during such work.


    2119/2523

    Tytuł oryginału: The third Multidisciplinary Conference on Drug Research MKNOL 2002, Piła, May 13-16, 2002.
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.413-482, il., tab., bibliogr. [przy ref.] - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    2120/2523

    Tytuł oryginału: Synthesis and biological properties of S-adamantylated heterocyclic compounds.
    Autorzy: Górska Agata, Świtaj Tomasz, Młynarczuk Izabela, Lasek Witold, Kazimierczuk Zygmunt
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.415-417, il., tab., bibliogr. 13 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: A series of new S-adamantylated compounds were prepared by adamantyl cation attack on the thiol group. The biological activity of new compounds as the inducers of TNF-ŕ in genetically modified mouse melanoma cells is presented.


    2121/2523

    Tytuł oryginału: Synthesis of new N-substituted cyclic imides with expected anxiolytic activity. [P.] 21: Derivatives of 1-acetyldibenzo-[e.h]-bicyclo[2.2.2]-octane-2,3-dicarboximide.
    Autorzy: Kossakowski Jerzy, Szczepek Wojciech, Pakosińska-Parys Magdalena
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.418-423, il., tab., bibliogr. 10 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The preapartion of a number of new N-substituted derivatives of 1-acetyldibenzo-[e.h]-bicyclo[2.2.2]-octane-2,3-dicarboximide with an expected anxiolytic activity is described.


    2122/2523

    Tytuł oryginału: Synthesis of new N-substituted cyclic imides with potential anxiolytic activity. [P.] 23: Derivatives of 2'-chlorodibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide.
    Autorzy: Kossakowski Jerzy, Perliński Mirosław
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.423-427, il., tab., bibliogr. 11 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The preparation of a number of derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide with an expected anxiolytic activity is described.


    2123/2523

    Tytuł oryginału: Antioxidative properties of coenzyme Q10 and vitamin E in exposure to xylene and gasoline and their mixture with methanol.
    Autorzy: Piotrowska D., Długosz A., Pająk J.
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.427-432, il., tab., bibliogr. 16 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Exposure to a mixture of solevents in industry is still a problem particularly in industrial laboratories. In the paint and laquer industry the employees are exposed to xylene (Rx) and gasoline (Rg). The influence of xylene and gasoline or their mixture with methanol on lipid peroxidation was evaluated in the presented paper. Antioxidative properties of CoQ10 or vitamin E were also tested. It was observed that xylene caused an increase of lipid peroxidation measured as a MDA level in all used concentration, but gasoline only in very high doses. The mixture of xylene with methanol increased significantly MDA level, whereas gasoline with methanol did not influence lipid peroxidation. The character of interaction depends on hydrocarbons dose. CoQ10 and vitamin E are effective antioxidants lowering the increased MDA level caused by xylene, gasoline or their mixture with methanol, however the dose of CoQ10 should be adjusted to the strength of oxidative stress in order to avoid disadvantageous effect. CoQ10 is a more effective antioxidant in exposure to xylene rather than gasoline, but vitamin E acts better in exposure to gasoline decreasing the MDA level.


    2124/2523

    Tytuł oryginału: Sterility and antibacterial activity of some antibiotics sterilized by irradiation.
    Autorzy: Muszyński Zygmunt, Długaszewska Jolanta, Marciniec Barbara, Płotkowiak Zyta, Popielarz-Brzezińska Maria, Ogrodowczyk Magdalena
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.433-435, tab., bibliogr. 13 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Sterility and antibacterial activity of several antibiotics (including some penicillins and their salts, gramicidin and neomycin) subjected to sterilization by irradiation has been studied. The compounds in solid phase have been exposed to gamma irradiation in air atmosphere at room temerature, with a dose of 25 kGy, and afterwards they have been subjected to tests recommended by FP V (volume I, 1990) checking their sterility and activity. The results have shown that the majority of initial compounds have been to a slight degree contaminated by bacteria from the genera Bacillus and Micrococcus, the number of bacteria did not exceed 10ý CFU, and fungi up to 10 CFU in 1 g of the compouned. All compounds subjected to sterilization with a dose of 25 kGy were sterile and preserved the activity required by FP V. The decrease in activity observed for some compounds was always within the limits of FP specification. The results have proved that the penicillins analysed, gramicidin and neomycin can be sterilized by irradiation with a dose of 25 kGy, without any detrimental effect on their properties and antibacterial activity.


    2125/2523

    Tytuł oryginału: Search antimicrobial activity of selected non-antibiotic drugs.
    Autorzy: Kruszewska Hanna, Zaręba Tomasz, Tyski Stefan
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.436-439, tab., bibliogr. 12 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A variety of pharmaceutical preparations, which are applied in the management of non-infectious diseases, have shown in vitro some antimicrobial activity. These drugs are called "non-antibiotics". The aim of this study was to detect and characterise the antimicrobial activity of non-antibiotic drugs, selected form the preparations analysed during state control performed at the Drug Institute in Poland. Over 160 pharmaceutical preparations were rendomly chosen from different groups of drugs. The surveillance study was performed on standard ATCC microbial strains used for drug control: S. aureus, E. coli, P. aeruginosa and C. albicans. It was shown that the drugs listed below inhibited growth of at least one of the examined strains: acyclovir (Awirol 5 p.c., cream), alendronate (Alenato 5 mg, tabl.), alverine (Meteospasmyl 20 mg, caps.), butorphanole (Butamidor 10 mg/ml, amp.), clodronate (Sindronat 400 mg, caps), diclofenac (Olfen 75 mg, amp.), emadastine (Emadine 0.05 p.c., eye dr.), etodolac (Febret 200 mg, caps), fluvastatine (Lescol 40 mg, tabl.), ketamine (Ketamidor 10 p.c., amp.), levocabastine (Histimet 0.5 mg/ml, eye dr.), losartan (Lorista 50 mg, tabl.), matipranolol (Betaman 0.3 p.c. eye dr.), mesalazine (Pentasa 1 p.c., susp.), naproxen (Nalgesin 550 mg, tabl.), oxaprosine (Reumax 600 mg, tabl.), oxymethazoline (Nasivin 0.025 p.c., nose dr.), proxymetacaine (Alcaine 0.5 p.c., eye dr.), ribavirin (Rebetol 200 mg, caps.), rutoside with ascorbic acid (Cerutin 20+200 mg, tabl.), sulodexide (Vessel due F, 250 LSU, caps.)...


    2126/2523

    Tytuł oryginału: Antimycobacterial activity of some pyrido-1,2-thiazine derivatives.
    Autorzy: Malinka Wiesław, Redzicka Aleksandra, Świątek Piotr
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.439-442, il., tab., bibliogr. 14 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: The 3-benzoylpyrido-1,2-thiazine-1,1-dioxides 1 and the related pyrazolopyrido-1,2-thiazine-5,5-dioxides 2 with a 4-arylpiperazin-1-ylpropyl side chained by the nitrogen atom of the thiazine ring were evaluated in vitro against Mycobacterium tuberculosis H37Rv. Some of the tested compounds proved to be potent antimycobacterial agents and for the most active of them (1a,b) minimum inhibitory concentrations (MIC = 3.13 and 6.25 ćg/ml, respectively) were determined. The correlation between mycobacterium growth inhibition and the lipophilicity (logPcalc.) within the series of derivatives 1 and 2 was studied.


    2127/2523

    Tytuł oryginału: The type of isoniazid acetylation in tuberculosis patients treated at National Tuberculosis and Lung Diseases Research Institute.
    Autorzy: Augustynowicz-Kopeć Ewa, Zwolska Zofia
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.443-447, il., tab., bibliogr. 11 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The research has dealt with types of acetylation in 237 TB patients treated by standard course of chemotherapy with a 300 mg dose of INH at the National Tuberculosis and Lung Disesase Research Institute in Warsaw (NTLDRI). Blood samples were taken before (time 0) and 1, 3, 6 and 24 h after drug administration. Plasma concentrations of isoniazid were determined with biological methods. Two indicators of acetylation rate - I3 and C6 have been used to determine the acetylation type. Majority of the treated patients (68.8 p.c.) have shown fast type of INH acetylation. After similar dose of isoniazid different profile of absorption and excretion of the drug and significant differences (p 0.01) in INH concentrations, acetylation rate and bioavailability between 163 fast and 74 slow acetylators have been observed. In plasma of 38.6 p.c. fast acetylators drug concentration 3h after ingestion of the dose did not achieve the concentration of 1 mcg/ml. In plasma of 29.7 p.c. slow acetylators, concentrations of INH 6h after ingestion were higher than 2 mcg/ml.


    2128/2523

    Tytuł oryginału: The pharmacokinetic factors and bioavailability of rifampicin, isoniazid and pyrazinamid fixed in one dose capsule.
    Autorzy: Zwolska Zofia, Augustynowicz-Kopeć Ewa, Niemirowska-Mikulska Hanna
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.448-452, il., tab., bibliogr. 10 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: A study was performed at the National Tuberculosis and Lung Diseases Research Institute (NTLDRI) in Warsaw according to the protocol by the Ethics Committee of the Institute. The main target of the mentioned study was a comparison of the biavailability of rifampicin, isoniazid and pyrazinamid fixed together in one capsule with the bioavailability of the same doses of these drugs, which were given sepatately. The absorption of rifampicin, isoniazid and pyrazinamid were tested after oral administration of each drug in free simultaneous combinations and in a fixed-dose combination of three drugs - Triazid. The study was carried out as an open randomised crossover experiment comprising 16 volunteers. The results have shown that the pattern of absorption, plasma concentrations and pharmacokinetic parameters were found to be very simular after administration of the drugs in free and fixed combinations. The triple combination of antituberculosis drugs could replace the separate drugs in the treatment of tuberculosis.


    2129/2523

    Tytuł oryginału: Bioavailability factors of isoniazid in fast and slow acetylators, healthy volunteers.
    Autorzy: Augustynowicz-Kopeć Ewa, Zwolska Zofia
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.452-457, il., tab., bibliogr. 21 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The INH metabolism mainly involves acetylation to acetyloisoniazid by a non inducible hepatic enzyme N-acetyltransferase. Examples of drugs acetylated by this enzymatic system are: isoniazid, sulphadimidine, hydrallazine, dapson and sulphapyridine. The rate of acetylation is constant in any individual but varies in different patients. People are characterized as rapid or slow acetylators with slow acetylation inherited as an autosomal recessive. Heterozygotes have intermediate acetylation rate. The articel presents comparative study of the bioavailability of INH in fast and slow acetylators un healthy volunteers. The results have shown that all compared parameters are significantly different in both groups of acetylators.


    2130/2523

    Tytuł oryginału: Essential oil from fruit of Peucedanum tauricum Bieb.
    Autorzy: Bartnik Magdalena, Głowniak Kazimierz, Mardarowicz Marek
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.457-459, il., tab., bibliogr. 6 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Essential oil from fruit of Peucedanum tauricum Bieb. was qualiatively and quantitatively investigated. The content of oil determined by distilation with water and m-xylene was 2.2 p.c. of dry mass. Gas chromatography (GC) with MS detection and flame ionisation detection (FID) showed that the oil contains 28 compounds (above 99 p.c. of sesquiterpense), of which 9 were identified as á-elemene (0.6 p.c.), á-caryophyllene (0.3 p.c.), ŕ-guaiene (0.2 p.c.), ŕ-humulene (0.8 p.c.), ç-gurjenene (5.6 p.c.), á-selinene (2.3 p.c.), ŕ-selinene (2.2 p.c.), ç-cadinene (0.3 p.c.). Predominating sesquiterpenoids (RI 1529 - 35.9 p.c., RI 1526 - 27.2 p.c., RI 1537 - 7.1 p.c.) were not identified, and their mass spectra were similar to mass spectra of selinene derivatives.


    2131/2523

    Tytuł oryginału: A comparative molecular surface analysis (COMSA). A new efficient technique for drug design.
    Autorzy: Polański Jarosław, Gieleciak Rafał, Jarzembek Krystyna, Wyszomirski Mirosław, Bąk Andrzej
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.459-461, il., tab., bibliogr. 8 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • aIDS
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Several applications of the COMSA were discussed including a series of the potential anti-HIV drugs and a series of dyes.


    2132/2523

    Tytuł oryginału: 13 C CPMAS NMR and molecular modeling in the studies of new analogues of buspirone.
    Autorzy: Pisklak Maciej, Perliński Mirosław, Kossakowski Jerzy, Wawer Iwona
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.461-465, il., tab., bibliogr. 8 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Three derivatives of 1,4 dichloro-dibenzo[e,h]-bicyclo[2,2,3]octane-2,3-dicarboximide were examined by 13C CPMAS NMR. Low energy conformations were found by a semi-empirical AM1 approach, NMR shielding constans were calculated using the GIAO RHF method.


    2133/2523

    Tytuł oryginału: Formation of secondary structures in polypeptides a Monte Carlo simulation.
    Autorzy: Sikorski Andrzej, Romiszowski Piotr
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.466-469, il., bibliogr. 7 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The lattice approximation of a polypeptide chain was used in the computer simulation. The residues of a model polypeptide were represented by the chain of ŕ-carbons located on a very flexible [310] lattice. The force field contained the long-range contact potential between the residues as well as the local preferences in forming helical structures. The chain consisted of two typs of residues: hydrophillic (P) and hydrophobic (H), forming a typical repeatable helical septet -HHPPHPP-. The simulations were performed by means of the Replica Exchange Monte Carlo method combined with the Histogram method. A series of simulations were performed enabling one to investigate the influence of both components of the force field on the transition temperature and the characteristics of the coil-globule transition. The properties of low-temperature ordered structurs were determined. The thermodynamical description of the model polypeptide was also given. The phase transition was found to be sharp and cooperative for longer and strong helical potential.


    2134/2523

    Tytuł oryginału: Computer simulation of the receptor-ligand system.
    Autorzy: Romiszowski Piotr, Sikorski Andrzej
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.469-472, il., bibliogr. 5 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny

    Streszczenie angielskie: A series of Monte Carlo simulation were carried out for receptor-ligand systems taken from the Protein Data Bank. The models or both objects were based on a simplified low-resolution model. The model chains consisted of alpha carbons and side groups represented by united atoms. The excluded volume effect and specific pairwise contact potential were introduced into the model. The process of docking was simulated step-by-step by random translations and reorientations of the ligand. The stability of complexes formed was investigated for a simple statistical potential between amino acid side groups. The feasibility of the model for finding the binding site on the receptor surface and the proper orientation of a docked ligand were also studied.


    2135/2523

    Tytuł oryginału: Current stratetgies for anticancer chemoprevention and chemoprotection.
    Autorzy: Krzystyniak Krzysztof L.
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.473-478, tab., bibliogr. 32 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Relatively new targets in drug design projects in cancer pharmacology include cytostatic agents, immune system modulators, and angiogenesis inhibitors. Preventive oncology applies pharmacological agents to reverse, retard, or halt progression of neoplastic cells to invasive malignancy. Prevention of cancer, however, can be accomplished through many strategies, including changes in diet and lifestyle. For example, The vast majority of lung cancers (80-90 p.c.) can be attributed to cigarette smoking and therefore, the most effective primary preventive strategy for lung cancer is to quit smoking. Chemoprevention through interruption of multistage carcinogenesis include different molecular targets. Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ER) agonists. Ligands for the peroxisome proliferator-activated receptor gamma (PPAR-gamma) suppress breast carcinogenesis in experimental models and induce differentiation of human liposarcoma cells. Selective PPAR modulators (SPARMs), by analogy to the SERM concept, are designed to have desired effects on specific genes relevant to carcinogenesis. Enzymatic approach in endocrine-related tumors involve inhibition of aromatase to prevent breast cancer and inhibition of 5-alpha-reductase to prvent prostate cancer. Down-regulation of inflammatory prostaglands synthesis by inhibition of cyclooxygenase -2 (COX-2), inhibition of the inducible nitric oxide synthase (iNOS), and simulation of phase II detoxication system, are currently examined in experimental models and clinical trials...


    2136/2523

    Tytuł oryginału: Comparative evaluation of safety and efficacy of pamidronate and zoledronic acid in multiple myeloma patients (single cenetr experience).
    Autorzy: Kraj Maria, Pogłód Ryszard, Maj Stanisław, Pawlikowski Jan, Sokołowska Urszula, Szczepanik Janusz
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.478-482, tab., bibliogr. 12 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • sprawozdanie
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Osteolytic bone destruction, caused by the aberrant production and activation of osteoclasts, results in significant morbidity for patients with multiple myeloma (MM). Pamidronate [(3-amino-1-hydroxypropylidene)-1,1-bis-phosphonate] inhibits osteoclastic activity and reduces bone resorption. A potency of zoledronic acid (2-[imidazol-1-y1]-1-hydroxyethylidence-1,1-bisphosphonic acid, a new third generation bisphosphonate, as inhibitor of resorption was 850-fold greater than pamidronate, as was shown in preclinical models of bone resorption. Randomized, double-blind study was conducted to compare the efficacy and safety of zoledronic acid and pamidronate for treating mycloma bone disease. Since March 1999 the efficacy and safety of pamidronate and zoledronic acid is evaluated in MM patients all receiving anti-myeloma chemotherapy acc. to VMCP/VBAP alternating regimen. Nine patients with stage III myeloma and osteolytic lesions (3 female, 6 male, median age 57 years, range 52-67, with monoclonal protein: IgG-7, IgA-2) were randomly assigned (1:1:1 ratio) to treatment with either 4 or 8 mg of zoledronic acid via 15-minute intravenous infusion or 90 mg of pamidronate via 2-hour intravenous infusion every 3 to 4 weeks for 12 months. All patients have received 500 mg of calcium supplements and 500 IU of vit.D, orally, once daily, for the duration of administration of study medication. In extension phase of the study (June 2000 - April 2002) patients did not received bisphosphonates. In 7 patients 18 cycles of assessed treatment was administered to each of them and one patient received 16 cycles...


    2137/2523

    Tytuł oryginału: Human herpes virus-8 implicated in pathogenesis of multiple myeloma.
    Tytuł polski: Wirus opryszczki-8 u człowieka jako czynnik patogenetyczny w szpiczaku mnogim.
    Autorzy: Awedan Abdulnaser, Ramadan Ahlam
    Źródło: Acta Haematol. Pol. 2002: 33 (1) s.67-73, tab., bibliogr. 41 poz., sum.
    Sygnatura GBL: 305,450

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka
  • mikrobiologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Ludzki wirus opryszczki 8 (HHV-8) jest wirusem opryszczki typu gamma. Został po raz pierwszy zidentyfikowany w tkankach mięsaka Koposi'ego u pacjentów z zespołem AIDS. Uważa się, że wirus ten może przyczynić się do rozwoju mięsaka kaposi'ego (KS), body cavity based lymphoma (BCBL) i choroby wieloogniskowej Castelmana. Fragmenty genomu HHV-8 zostały ostatnio znalezione w hodowlach komórek zrębu szpiku chorych na szpiczaka mnogiego, wykorzystano do tego metodę PCR i hybrydyzacji in situ. Wirus wykrywany jest rownież we krwi wzbogaconej w komórki dendrytyczne pacjentów chorych na szpiczaka mnogiego. HHV-8 nie stwierdza się we krwi obwodowej rodzin pacjentów i u ich partnerów seksualnych. Dodatkowo genom HHV-8 zawiera kod dla wirusowej IL-6, która jak jej ludzki odpowiednik umożliwia wzrost i zapobiega apoptozie w ludzkich i murine hodowlach komórek szpiczakowych, sugeruje to udział HHV-8 w patogenezie szpiczaka mnogiego. Rola HHV-8 w patogenezie szpiczaka mnogiego wymaga dalszych badań, ponieważ niektórzy badacze nie zajmowali się HHV-8 w komórkach szpiku i we krwi obwodowej chorych na szpiczaka mnogiego. Także nie powiodły się badania serologiczne HHV-8 u chorych na szpiczaka mnogiego i ich partnerów seksualnych. Pomimo, że niektóre badania wskazują na możliwość udziału HHV-8 w patogenezie szpiczaka mnogiego, nadal należy prowadzić badania, które wyjaśnią dokładnie te mechanizmy. Wyjaśnienie tych mechanizmów może prowadzić do znaczących zmian w terapii tego ...

    Streszczenie angielskie: Human herpers virus-8 (HHV-8) is a gamma-herpers virus that was first identified in the Kaposi's sarcoma tissue of acquired immune deficiency syndrome patients. It has been implicated in the pathogenesis of Kaposi's sarcoma (KS), body cavity based lymphoma (BCBL) and multicentric Castelman's disease. HHV-8 genomic sequences were recently detected by polymerase chain reaction (PCR) and in situ hybridization in bone marrow stromal cells grown from multiple myeloma patients. The virus is also detectable in the peripheral blood enriched with dendritioc cells of most multiple myeloma patients. HHV-8 is not detected in the peripheral blood of family members and sexual partners of myeloma patients. In addition, HHV-8 encodes a viral homologue of IL-6, which like its human counterpart is capable of stimulating growth and preventing apoptosis of murine and human nyeloma cell lines, suggesting a role for HHV-8 in the pathogenesis of myeloma. However, the association between multiple myeloma and HHV-8 still remains controversial issue, bacause some investigators have been unable to find HHV-8 virus in bone marrow and peripheral blood of multiple myeloma patients. Moreover, serological assays have failed to detect HHV-8 expression in-patients with multiple myeloma and in sexual partners. Although some studies suggest a potential role of HHV-8 in pathogenesis of multiple myeloma, further work is required to establish this connection clearly. The establishment of such link could ...


    2138/2523

    Tytuł oryginału: Autologous stem cell transplantation in multiple myeloma - a single center experience.
    Tytuł polski: Przeszczepianie autologicznych obwodowych komórek macierzystych szpiku u chorych na szpiczaka plazmocytowego - doświadczenia własne.
    Autorzy: Wach Małgorzata, Legieć Wojciech, Jawniak Dariusz, Cioch Maria, Walter-Croneck Adam, Małek Magdalena, Hus Marek, Mańko Joanna, Wąsik-Szczepanek Ewa, Gorący Aneta, Tomczak Waldemar, Dmoszyńska Anna
    Źródło: Acta Haematol. Pol. 2002: 33 (1) s.93-100, il., tab., bibliogr. 26 poz., sum.
    Sygnatura GBL: 305,450

    Hasła klasyfikacyjne GBL:
  • onkologia
  • hematologia
  • transplantologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Średni czas przeżycia chorych na szpiczaka plazmocytowego, leczonych przy pomocy konwencjonalnej chemioterapii wynosi około 3 lat. Obecnie standardowym leczeniem przede wszystkim dla młodszych chorych stała się wysokodawkowana chemioterapia wspomagana podawaniem autologicznych obwodowych komórek macierzystych. W okresie listopad 1997 - wrzesien 2001 w Klinice Hematologii i Transplantacji Szpiku w Lublinie u 36 chorych na szpiczaka plazmocytowego przeprowadzono zabieg przeszczepienia autologicznych obwodowych komórek macierzystych. Wśród chorych było 15 kobiet i 11 mężczyzn, średnia wieku wynosiła 51.9 lat (ń 8,45), mediana 51 (zakres: 38-65). U 7 chorych wykonano procedurę transplantacji dwukrotnie. Przed transplantacją 17 chorych było w całkowitej remisji, 14 w częściowej remisji, 1 był w okresie aktywnej choroby pomimo leczenia, 4 chorych nie było uprzednio leczonych. W wyniku procedury mobilizacyjnej z zastosowaniem wysokodawkowego cyklofosfamidu i G-CSF uzyskano średnio 7,53 (ń 5,55), mediana 6,34 x 10**6/kg (zakres: 1,20 - 26,7 x 10**6) komórek CD34+ dla jednego pacjenta. Protokół kondycjonujący składał się z wysokodawkowanego alkeranu (melfalanu), w dawce 60-210 mg/mý, bez stosowania napromieniania całego ciała (TBI-total body irradiation). Regeneracja hematopoezy przebiegała następująco: powrót granulocytozy 0,5 x 10**9/l osiągnięto średnio w dniu +13,7 (ń 3,99), mediana 13 (zakres: 9-30), liczby płytek 20 x 10**/l osiągnięto średnio w dniu +16,5 (ń 5,68), ...

    Streszczenie angielskie: Patients with multiple myeloma (MM) treated with conventional chemotherapy have a median survival of approximately 3 years. High dose chemotherapy followed by autologous peripheral stem cell transplantation (PBSCT) is now considered as the standard therapy for almost all patients with multiple myeloma. From November 1997 to september 2001, 36 patients with MM (15 females, 21 maled) mean age - 51.9 year (ń .45), median 51, (range: 38-65) were tranplanted in our Department. In 7 patients double transplantation was performed. Before transplantation 17 patients were in first complete remission, 14 patients were in partial remission, 1 was in SD, 4 out of them were without any treatment. In mobilisation procedure with high dose cyclophosphamide and G-CSF a mean of 7.53 (ń 5.55), median 6.34 x 10**6 CD34+ cells/kg (range: 1.20 - 26.7 x 10**6) were collected for one patient. Conditioning regimen consisted of high dose melphalan 60-210 mg/mý without TBI. The meandays for recovery of ANC 0,5 x 10**9/l was 13.7 (ń 3.99), median 13 (range: 9-30) and platelets recovery 20 x 10*9/l was 16.5 (ń 5.68), median 15 (range: 7-30). treatment related morality = 0. At present 34 patients are alive (94.5 p.c.), 6 in PR (16.7 p.c.), 4 in SD (11.1 p.c.), 6 in relapse (16.7 p.c.). Two patients died 9 and 28 months after transplantation in relapse (5.5 p.c.). High-dose chemotherapy followed by autologous stem cell transplantation is a valuable and well tolerated method of treatment for ...


    2139/2523

    Tytuł oryginału: Principal component analsyis of patient variables as an objective method of classification of thyroid disorders.
    Tytuł polski: Analiza składników głównych jako obiektywny sposób klasyfikacji schorzeń tarczycy.
    Autorzy: Buciński Adam, Krysińska Iwona, Sowiński Jerzy, Bączek Tomasz, Kaliszan Roman
    Źródło: Endokrynol. Pol. 2002: 53 (2) s.123-136, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Analiza składników głównych (principal component analysis, PCA) wykorzystana została do obiektywnej klasyfikacji pacjentów ze schorzeniami tarczycy. Analiza PCA została przeprowadzona na dużym zbiorze parametrów klinicznych. Metoda pozwoliła na ocenę złożonych zależności pomiędzy zmiennymi charakteryzującymi pacjentów i choroby, w konsekwncji umożliwiając klasyfikację poszczególnych schorzeń tarczycy. Studia przeprowadzono na grupie 230 pacjentów cierpiących na sześć schorzeń tarczycy. Pacjentów charakteryzowało 6 zmiennych, włączając płeć, wiek i oznaczony we krwi poziom pięciu hormonów. Macierz 230 x 6 została poddana analizie składników głównych wykorzystując komercyjnie dostępny program statystyczny i komputer osobisty. Wyekstrahowane dwa składniki główne, PC1 i PC2, opisują 63,09 proc. całkowitej zmienności próby. Wyraźne zróżnicowanie położeń punktów w przestrzeni wyznaczonej przez dwa pierwsze składniki główne interpretowano w kategoriach podobieństw (różnic) między przypadkami.

    Streszczenie angielskie: An advanced multivariate data processing method, principal component analysis (PCA), was demonstrated to provide an objective classification of patients with tyroid disorders by making use of large collections of routine clinical parameters of patients. The method allows for detection of complex systematic relationships between diverse patient and disease variables and hence for the classification of individual thyroid disorders. Two hundred thirty patients with six kinds of thyroid disorders were subjected to the study for whose seven variables including sex, age and blood level of five hormones were determined. A matrix of 230 x 7 data points was analyzed by PCA employing commercially available statistical software and a personal computer. Two principal components, PC1 and PC2, were extracted which accounted cumulatively for 63.09 p.c of the variance in the data set. A clear-cut clustering of patients have been observed, which are interpreted in terms of similarity (dissimilarity) of the variables and of the patients.


    2140/2523

    Tytuł oryginału: Abnormalities in bone metabolism in children with long-term glucocorticoid treatment.
    Tytuł polski: Nieprawidłowości metabolizmu kostnego u dzieci leczonych przewlekle glukokortykoidami.
    Autorzy: Chlebna-Sokół Danuta, Loba-Jakubowska Elżbieta, Rusińska Agnieszka, Lorenc Roman S., Lewiński Andrzej, Bodalski Jerzy
    Źródło: Endokrynol. Pol. 2002: 53 (2) s.159-170, il., tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • pediatria
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Zastosowanie glukokortykoidów u dzieci jest nadal wymagane w leczeniu niektórych chorób, np. chorób o podłożu autoimmunologicznym, chorób nowotworowych lub chorób ustrojowych tkanki łącznej. Jednakże zastosowanie kortykoterapii może się wiązać z wieloma zaburzeniami. Spośród nich, zaburzenia w mineralizacji kości zasługują na szczególną uwagę. Najczęściej obserwowanymi zaburzeniami są osteoporoza i osteopenia, wywołane kortykosteroidami, wraz z wtórnym obniżeniem gęstości mineralnej kości u dzieci poddanych długotrwałemu leczeniu glukokortykoidami. Ten mechanizm, który prowadzi do osteoporozy, jest złożony i wielokierunkowy i jest zarówno skutkiem wpływu glukokortykoidów na metabolizm wapnia i fosforu, jak i bezpośredniego wpływu tych hormonów na komórki kości. U dzieci i młodzieży, długotrwałe podawanie glukokortykoidów prowadzi do zahamowania procesu kościotworzenia w większym stopniu niż do stymulacji resorpcji. Celem badania było określenie wpływu długotrwałej kortykoterapii na metabolizm kostny (gęstość mineralną kości i biochemiczne wskaźniki metabolizmu kostnego) u dzieci.

    Streszczenie angielskie: The use of glucocorticoids in children is still necessary in the treatment of some diseases, e.g., diseases with autoimmunologic background, as well as neoplastic and systemic diseases of the connective tissue. However, the use of corticotherapy can bring about a number of many disturbances. Among them, disturbances in bone metabolism are of special importance, the most common ones being the corticosteroid-induced osteoporosis and osteopenia, with secondary decrease of bone mineralization in children with long-term glucocorticoid treatment. The mechanism which leads to osteoporosis is complex and multidirectional, and results from the effect of glucocorticoids on calcium and phosphorus metabolism and direct influence of glucocorticoids on bone cells. In children and adolescents, long-term use of glucocorticoids leads, in the first instance, to predominance of bone formation inhibition rather than to stimulation of resorption. The aim of the study is to determine the influence of long-term corticotherapy on bone metabolism (bone mineral density and biochemical markers of bone metabolism) in chldren.


    2141/2523

    Tytuł oryginału: Bone mineral density in type 1 diabetic patients.
    Tytuł polski: Gęstość mineralna kości u pacjentów z cukrzycą typu 1.
    Autorzy: Bohchelian Hripsime A., Koeva Lidia A.
    Źródło: Endokrynol. Pol. 2002: 53 (2) s.171-179, il., tab., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było zbadanie występowania osteopenii i osteoporozy u pacjentów z cukrzycą typu 1 oraz związku między tymi zaburzeniami i stopniem kontroli glikemi,, jak i niektórymi powikłaniami cukrzycowymi - neuropatią cukrzycową, retinopatią, nefropatią. Metody: Badaniem objęto 400 pacjentów z cukrzycą typu 1. Analizie poddano stężenie cukru we krwi przed i po posiłku, poziom HbA1c, stężenie cukru w moczu oraz poziom mikroalbuminurii. Badano również czucie wibracji i odczuwania ucisku. Przeprowadzone zostały badania osteodensytometryczne. Wyniki: Osteopenia została zdiagnozowana u 32 proc., zaś osteoporoza u 26 proc. pacjentów z cukrzycą typu 1. Osteoporozę rozpoznano u 29 proc. pacjentów z niedostateczną kontrolą glikemii we krwi oraz u 14 proc. pacjentów ze skutecznym nadzoerm tego stężenia. Pacjenci z widoczną polineuropatią lub z szeregiem powikłań cukrzycowych, wykazują niższe wartości BMD, częściej stanowią przypadki osteoporozy. Wnioski: Przypadki osteopenii i osteoporozy są często obserwowane spośród pacjentów z cukrzycą typu 1. Pacjenci z cukrzycą typu 1 i powikłaniami naczyniowymi wykazują wyższe zagrożenie osteoporozą - zagrożenie to jest dodatnio skorelowane z cukrzycową retinopatią, polineuropatią i nefropatią. Zaleca się wykonywanie osteodensytometrii jako metody badań przesiewowych i fragment procedur monitorowania cukrzycy. Dodatkowym celem skutecznego prowadzenia cukrzycy powinno być utrzymanie normalnej gęstości kostnej. Wczesne rozpoznanie, ...

    Streszczenie angielskie: The aim of the study was to investigate the prevalence of osteopenia and osteoporosis in patients with type 1 diabetes and their correlation to the degree of glycaemic control and some diabetic complications - diabetic neuropathy, retinopathy, nephropathy. Methods: The object of investigation were 400 patients with type 1 diabetes mellitus. Pre- and postprandial blood glucose levels, HbA1c, urine glucose, and microalbuminuria were analyzed. Vibration sensation and pressure perception were determined. Osteodensitometry was carried out. Results: Osteopenia was established in 32 p.c., while osteoporosis was found in 26 p.c. of patients with type 1 diabetes. Osteoporosis was found in 29 p.c. of patients with poor glycaemic control and in 14 p.c. of patients with good glycaemic control. Patients with available diabetic polyneuropathy or several diabetic complications reveal lower values of BMD and are more frequently osteoporotic. Conclusion: Osteopenia and osteoporosis are frequent among type 1 diabetics. Patients with type 1 diabetes and vascular complicatons have higher osteoporotic risk - the risk is positively correlated to diabetic retinopathy, polyneuropatry, nephropathy. Osteodensitometry is recommended as a screening method and part of diabetes' monitoring protocol. Normal bone density could be an additional target of good metabolic control. The early diagnosis, monitoring, and treatment of osteoporosis should be part of the preventive program and complex ...


    2142/2523

    Tytuł oryginału: Effect of iodine on oxidative stress in selected rat organs.
    Tytuł polski: Wpływ jodu na stres oksydacyjny w wybranych narządach szczura.
    Autorzy: Świerczyńska-Machura Dominika, Sewerynek Ewa, Lewiński Andrzej
    Źródło: Endokrynol. Pol. 2002: 53 (2) s.181-189, il., bibliogr. 29 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Podawanie jodku potasu zwierzętom hodowanym na terenach niedoboru jodu, może indukować martwicę i włóknienie gruczołu tarczowego. Uważa się iż morfologiczne i czynnościowe zmiany w tarczycy mogą być związane z procesami oksydacyjnymi. Peroksydacja lipidów jest najlepiej poznanym biologicznym, wolnorodnikowym, wieloetapowym procesem, w którym najczęściej oznaczanym parametrem jest dialdehyd malonowy (MDA). Many i wsp. [1991] wykazali wzrost stężenia MDA w tarczycy zwierząt otrzymujących duże dawki jodków oraz częściowy ochronny wpływ antyoksydantów. Celem pracy była ocena procesów oksydacyjnych zachodzących w czterech narządach (wątrobie, mózgu, płucu i nerce) u szczurów otrzymujących różne dawki jodku potasu w diecie. Wykazano, wzrost stężenia MDA w badanych narządach, w porównaniu z grupą kontrolną. W niektórych tkankach (wątroba, nerki) obserwowano spadek stężenia MDA dla grup o wysokiej zawartości jodu. Wykazano także wzrost poziomu zasad Schiffa (SB) w płucu, mózgu i wątrobie w porównaniu z grupą kontrolną. Wyniki otrzymanych stężeń MDA i SB wskazują na udział jodku potasu w procesach oksydacyjnych nie tylko w tarczycy, ale także w innych narządach. Nasze wyniki potwierdzają narządowe różnice w peroksydacji lipidów, które mogą być związane z odmienną wrażliwością badanych tkanek na skutki stresu oksydacyjnego.

    Streszczenie angielskie: Iodine administration to animals, kept in iodine-deficient areas, can induce necrosis and fibrosis of the thyroid gland. It is belied that structural and functional changes of the thyroid may be related to oxidative processes. Lipid peroxidation is the most well-known biological, free-radical process with several stages, and malondialdehyde is the most often detected parameter. Many et al. [1991] have found increased malondialdehyde concentrations in animal thyroid glands after high doses of iodine and a partial protection by antioxidants. The goal of the study was to evaluate oxidative processes in four rat organs (the liver, brain, lung and kidney) during treatment with different doses of iodine. We found increased MDA concentrations in each organ, compared to that in the control group. in some tissues (liver, kidney), a decrease of MDA was noted for groups with high concentrations of iodide in diet. We also noted increased SB levels in the lung, the brain and the liver, when compared to those observed in controls. The results of malondialdehyde and Schiff's base concentrations indicate that iodine is involved in oxidative processes not only in the thyroid but also in other organs. Our results confirm the differences of organ lipid peroxidation, which may be related to different sensitivity rates of examined tissues to oxidative damage.


    2143/2523

    Tytuł oryginału: Asymmetry of the neuroendocrine reproductive system.
    Tytuł polski: Asymetria neuroendokrynnego układu rozrodczego.
    Autorzy: Gerendai Ida, Banczerowski P‚ter
    Źródło: Endokrynol. Pol. 2002: 53 (2) s.191-201, bibliogr. 51 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W ciągu ostatnich dwóch dziesięcioleci opublikowano dużą liczbę doniesień - przy czym liczba tych materiałów wciąż rośnie - poruszających temat asymetrii struktur podwzgórzowych, limbicznych oraz innych struktur ośrodkowego jak i obwodowego układu nerwowego, uczestniczących w kontroli gruczołów płciowych. Asymetria morfologiczna, biochemiczna i czynnościowa jest obecna na każdym poziomie tego układu kontroli. Ponadto, obserwuje się też różnice uboczne (rozwojowe, morfologiczne, czynnościowe). Poniższa praca stanowi skrótowy przegląd danych doświadczalnych oraz obserwacji klinicznych, wykazujących asymetrię neurendokrynnego układu rozrodczego.

    Streszczenie angielskie: Increasing number of evidences have been accumulated in the last two decades on the asymmetry of hypothalamic, limbic, and other central and peripheral nervous system structures involved in the control of the gonads. Morphological, biochemical, and functional asymmetry are present at each level of the control system. In addition, sided differences (developmental, morphological, functional) are also know. THe review summarizes experimental data and clincial observations indicating asymmetry of the neurendocrine reproductive system.


    2144/2523

    Tytuł oryginału: Selected immunological and allergological factors in subglottic laryngitis in children.
    Tytuł polski: Wybrane czynniki immunologiczne i alergologiczne w podgłośniowym zapaleniu krtani u dzieci.
    Autorzy: Zielnik-Jurkiewicz Beata
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.179-184, tab., bibliogr. 46 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy była ocena wybranych wskaźników immunologicznych i alergicznych w podgłośniowym zapaleniu krtani u dzieci. Na podstawie analizy wyników uzyskanych u chorych na podgłośniowe zapalenie krtani stwierdzono, że przeważającą grupę stanowią obciążeni atopią chłopcy w wieku od 1 do 3 lat. U atopowych chorych na podgłośniowe zapalenie krtani poniżej 3. roku życia dominowała nadwrażliwość na alergeny pokarmowe, a powyżej 3. roku życia nadwrażliwość na alergeny wziewne. Dokładna analiza uzyskanych wyników sugeruje, że podgłośniowe zapalenie krtani może być następstwem oddziaływania czynników alergicznych. Stwierdzona przewaga liczbowa chorych z atopią stwarza konieczność dokonywania diagnostyki alergologicznej w przebiegu podgłośniowego zapalenia krtani, co umożliwia wdrożenie właściwego postępowania leczniczego.

    Streszczenie angielskie: The aim of this study is to assess the impact of some selected allergic factors on the occurrence of subglottic laryngitis in children. Based on the analysis of the received results, the majority of patients sufferting from subglottic laryngitis were boys aged 1 - 3 years suffering from atopy at the same time. The patients with subglotic laryngitis and atopy younger than 3 years were predominantly allergic to food, whereas those older than 3 inhalant allergens. The detailed analysis of the received results suggests that subglotic laryngitis can be related to allergic factors. The fact that the majority of patients with subglottic laryngiytis suffered parallelly from atopy means that allergy-oriented diagnosis is a must in the course of subglottic laryngitis treatment and can help apply proper treatment methods.


    2145/2523

    Tytuł oryginału: Allergy to chemical disinfectants of medical staff handling disinfection in the operating theatres of hospitals in Lithuania.
    Autorzy: Jankauskas R., Dubakiene R., Jurkuvenas V.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.185-190, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • immunologia
  • chirurgia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem badania była ocena chemicznych preparatów dezynfekujących w środowisku roboczym, ocena stosowania środków ochrony osobistej i uczulenia na chemiczne substancje dezynfekujące wśród personelu medycznego, zajmującego się materiałami dezynfekującymi w szpitalach. Badanie przeprowadzono w 9 szpitalach w Wilnie, w latach 2000-2001. Testy wrażliwości na preparaty dezynfekujące wykonano u 314 ochotników, członków personelu medycznego, pracujących z chemicznymi preparatami dezynfekującymi od co najmniej 6 miesięcy. Wszystkich uczestników badania poddano testom płatkowym (patch test) na alergeny preparatów dezynfekujących i pytano o stosowanie środków ochrony osobistej. Badanie wykazuje, że podczas dezynfekcji i 20-30 minut po dezynfekcji stężenie badanych substancji (z wyjątkiem alkoholu etylowego) przekraczały maksymalne dopuszczalne stężenie w 29 proc. wszystkich pomiarów: alkohol izopropylowy - w 100 proc., nadtlenek wodoru - w 49 proc., glutaraldehyd - 18 proc., chlor - 5 proc. wszystkich pomiarów. Podczas testów płatkowych obserwowana częstość wrażliwości na badane chemicznie preparaty dezynfekujące wynosiła 49,0 proc. najwięcej dodatnich reakcji alergicznych stwierdzano w przypadku związków alkiloaminowych (47 proc.), chlorku benzalkonium (45,3 proc.), związków amonmowych (32,0 proc.), nadboranu sodu (25,5 proc.), chloroheksydyny (25,0 proc.), aldehydu glutarowego (22,6 proc.), dichlorizocyjanomoczanu sodu (15,8 proc.), nadtlenku wodoru (13,9 proc. oraz chloraminy ...

    Streszczenie angielskie: The aim of the study was estimation of chemical disinfectants concentrations in the working environment, the use of personal protective means and allergy to chemical disinfectants of medical staff handling chemical disinfection materials at hospitals. The study was conducted in nine hospitals in Vilnius in the years 2000-2001. Tests of sensitivity to disinfecting materials were performed in 314 volunteers, medical employees working with chemical disinfecting materials for six months at least. All the study participants were patch tested for disinfecting allergens and were questioned about the use of personal protective means. The study shows, that during disinfecting and 20-30 minutes after the disinfection, the established concentrations of dtested disinfectants (except of ethyl alcohol) have exceeded maximal acceptable concentrations in 29 p.c. of all measurements: isopropyl alcohol - in 100 p.c., hydrogen peroxide - in 49 p.c., glutaraldehyde - in 18 p.c., chlorine - in 5 p.c. of all measurements. During the patch testing the observed prevalence of sensitivity to tested chemical disinfectants amounted to 49 p.c. Most positive allergic reactions were established for alkylamine compounds (47.1 p.c.), benzalkonium chloride (45.3 p.c.), ammonium compounds (32.0 p.c.), sodium perborate (22.5 p.c.), chlorhexidine (25.0 p.c.), glutaraldehyde (22.6 p.c.), sodium dichlorocyanurate (15.8 p.c.), hydrogen peroxide (13.9 p.c.) and chloramine (7.5 p.c.). During disinfecting ...


    2146/2523

    Tytuł oryginału: Newborn screening for cystic fibrosis.
    Tytuł polski: Badania przesiewowe noworodków w kierunku mukowiscydozy.
    Autorzy: Skarzyński A., Kempa M., Kulczycki L. L.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.191-193, bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie polskie: Mukowiscydoza we wczesnym dzieciństwie stwarza problemy diagnostyczne. Z tego powodu nastąpił znaczny postęp w badaniach klinicznych nad tą chorobą, mający na celu opracowanie nowych metod diagnostycznych i terapeutycznych. Tylko 60 proc. chorych ma postawione rozpoznanie mukowiscydozy w pierwszym roku życia, a 80 proc. w ciągu pierwszych 3 lat życia. Wielu chorych pozostaje bez rozpoznania choroby przez kilka, a nawet kilkanaście lat. Było to powodem opracowania programu badań przesiewowych noworodków, które rozpoczęły się we wczesnych latach 60. i są stale udoskonalane. Umożliwiają wczesne wykrywanie osób podejrzanych i potwierdzanie rozpoznania za pomocą badania potu, wczesne włączanie leczenia, edukację rodziców i rodziny co do postępowania z chorym dzieckiem i uczulenie ich na wukrywanie ewentualnych powikłań mukowiscydozy. W pracy podkreślono znaczenie prenatalnych badań genetycznych i poradnictwa genetycznego dla rodzin chorych na mukowiscydozę.

    Streszczenie angielskie: Cystic fibrosis (CF) is a diagnostic problem in early childhood. Therefore, a significant progress has been observed in clinical studies on this disease in order to develop new diagnostic and therapeutic methods. Only 60 p.c. of patients with CF are diagnosed in the first year of life, and 80 p.c. in the first three years. Many patients renain undiagnosed for several or even over ten years. Therefore, screning programmes have been developed which started in early 1960s and have been constantly improved since then. They enable detection of suspected persons and confirmation of the diagnosis with sweat test, early introduction of treatment, education of parents and family members as to management of the sick child and making them vigilant with respect to detection of possible CF complications. In the paper importance is also stressed of prenatal genetic tests and genetic counselling for families of CF patients.


    2147/2523

    Tytuł oryginału: Actin content and polymerization in esophageal achalasia.
    Tytuł polski: Zawartość i polimeryzacja aktyny w achalazji przełyku.
    Autorzy: Augof K., Lewandowski A., Taboła R., Rosińska T.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.194-197, il., tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: W próbkach warstwy mięśniowej zwieracza przełyku, pobranych od 28 chorych z achalazją i od 11 kontrolnych badano zawartość monomeru aktyny G, aktyny całkowitej i włókienkowej aktyny F. Zawartość aktyny mierzono poprzez zahamowanie standardowej DNAzy I z trzustki bydlęcej. Wyraźny spadek zawartości aktyny G (p 0,001) i wysoce znamienny wzrost stanu polimeryzacji aktyny (p 0,001), mierzony stosunkiem aktyny F:G wykazano w tkankach chorych z achalazją w stosunku do wyników otrzymanych w tkankach prawidłowych. Nie stwierdzono istotnych różnic pomiędzy poziomami aktyny całkowitej i włókienkowej w obu grupach. W grupie tkanek z achalazją, 83,8 proc. aktyny całkowitej stwierdzono w włókienkach, w przeciwieństwie do grupy kontrolnej, gdzie we włókienkach wykazano obecność tylko 69,9 proc. aktyny. Badania te sugerują, że zmiany stanu polimeryzacji aktyny mogą mieć udział w patologicznych mechanizmach achlazji przełyku.

    Streszczenie angielskie: Monomeric G-actin, total actin and filamentous F-actin were examined in muscular coat of esophageal sphincter taken from 28 achlasia patients and 11 controls. Actin was measured by the inhibition of standard Dnase I from bovine pancreas. A remarkable decrease in G-actin content (p 0.001) and highly significant increase in the state of actin polymerization (p 0.001), measured by the F:G actin ratio was shown in tissues with achalasia as compared with the results obtained for the normal tissues. There werwe no significant differences between levels of total and filamentous actin in these both groups. In the group of achalasic tissues 83.8 p.c. of total actin was found in filaments in contrast to control whwre only 69.9 p.c. of the actin was demonstrated in filaments. These studies suggest that changes in state of actin polymerization may participate in pathological mechanisms of esophageal achalasia.


    2148/2523

    Tytuł oryginału: Investigations on the role of immunological factors in aseptic loosening of cemented and uncemented hip prosthesis. [P.] 4: Discussion.
    Tytuł polski: Badania nad rolą czynników immunologicznych w obluzowaniu aseptycznym całkowitej cementowej i bezcementowej protezy stawu biodrowego.
    Autorzy: Denys P., Szmigiel A., Dudkiewicz Z.
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.198-203, bibliogr. 33 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • immunologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W pracy omowiono przyczyny jałowego obluzowania endoprotezy stawu biodrowego zarówno w oparciu o przegląd piśmiennictwa, jak i badania własne. Mają znaczenie nie tylko wybór endoprotezy i zastosowanie techniki operacyjnej, ale także czynniki immunologiczne. Wydaje się, że strukturą docelową w planowanej interwencji immunologicznej jest TNF-ŕ, cytokina, która stymuluje proces osteolizy.

    Streszczenie angielskie: The paper, based on literature and the author's own investigations, presents the causes of aseptic loosening of hip prosthesis. Not only the choice of prosthesis and operational techniques but also immunological factors are important in the process of aseptic loosening. TNFŕ, the cytokine which stimulates osteolysis, seems to be the target structure in the planned immunological intervention.


    2149/2523

    Tytuł oryginału: Hypokalemic quadriparalysis and respiratory arrest due to Sj”gren's syndrome.
    Tytuł polski: Hipokaliemiczne porażenie czterokończynowe i zatrzymanie oddechu w następstwie zespołu Sj”grena.
    Autorzy: Yesari Karter, Aydin Tunckale, Nurver T. Ertrk, Isil T. Bavunoglu, Asli Curgunlu, Esin ™ztrk
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.205-207, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie polskie: Porażenie hipokaliemiczne jest rzadkim objawem zespołu Sj”grena (ZS). Jest częściej obserwowane u chorych z pierwotnym ZS, może poprzedzać zespół suchości i może służyć za marker kliniczny poważniejszej choroby nerek u chorych z pierwotnym ZS i kwasicą kanalikowo-nerkową (KKN). Opisano przypadek 19-letniej kobiety z Turcji, przyjętej z hipokaliemicznym porażeniem czterokończynowym, zatrzymaniem oddechu i bradykardią zatokową. Oceniając kwasicę metaboliczną u tej chorej, autorzy stwierdzili, że była ona wynikiem KNN typu I (KKN dystalna) w następstwie istnienia ZS.

    Streszczenie angielskie: Hypokalemic paralysis is a rare manifestation of Sj”gren's syndrome (SS). It is seen more often in patients with primary SS, may precede the sicca compelx and may serve as a clinical marker for more severe renal disease in patients who have primary SS and renal tubular acidosis (RTA). We describe the case of a 19-year-old girl from Turkey who presented with hypokalemic quadriparalysis, respiratory arrest and sinus bradycardia. Evaluating the metabolic accidosis in the girl, we found that it was the results of type I RTA (distal RTA) due to the existence of SS.


    2150/2523

    Tytuł oryginału: Hypereosinophilic syndrome with right ventricular thrombus.
    Tytuł polski: Zespół hipereozynofilii ze skrzepliną prawokomorową.
    Autorzy: Turfaner Nurver Ertrk, Yesari Karter, Ayan Faruk, ™ng”ren Seniz, Yaldiran Adnan, Sipahioglu Fikret, Esin ™ztrk
    Źródło: Int. Rev. Allergol. Clin. Immunol. 2002: 8 (3) s.208-209, il., bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 313,209

    Hasła klasyfikacyjne GBL:
  • hematologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie polskie: Eozynofilią określa się występowanie ponad 500 granulocytów eozynochłonnych w mm3 krwi. U ludzi jest to bardzo czeste zjawisko. Zespół samoistnej hipereozynofilii jest rzadkim zaburzeniem objawiającym się stale utrzymującą się eozynofilią na poziomie 1500 granulocytów eozynochłonnych/mm3 przez ponad 6 miesięcy i domniemanymi obiektywnymi i subiektywnymi objawami zaburzeń czynności lub zajęcia układów narządów, ktore wydają się związane z eozynofilią. Możliwe jest określenie etiologii alergicznej, pasożytniczej lub innej. Objawy mogą być hematologiczne, skórne, oczne, reumatologiczne, neurologiczne, płucne, żołądkowo-jelitowe lub sercowe, w zależności od zajętego ukladu. Zajęcie układu krążenia jest najważniejszą przyczyną śmiertelności i chorobowości. Omówiono rzadki przypadek zespołu hipereozynofilii powikłanego skrzepliną prawokomorową u 38-letniego mężczyzny.

    Streszczenie angielskie: Eosinophilia is the presence of more than 500/mm3 eosinophils in the blood and it is very common in humans. Idiopathic hypereosinophilic syndrome (HES) is a rare disorder which appears with persistent eosinophilia of 1500 eosinophilis/mm3 for more than 6 months and presumptive signs and symptoms of organ system dysfunction or involvement which appears related to the eosinophilia. It is impossible to determine an allergic, parasitic or other etiology. The symptoms may be hematologic, cutaneous, ocular, rheumatologic, neurologic, pulmonary, gastrointenstinal or cardiac accoprding to the involved system. Cardiac involvement is the most important cause of mortality and morbidity. A 38-year-old man with hypereosinophilic syndrome complicated by right ventricular rhrombus, which is a rare presentation, is discussed.


    2151/2523

    Tytuł oryginału: Nitric oxide stimulation of cardiac pacemaking in the sino-atrial node through the activation of a novel signalling pathway: Overview of in vitro and in vivo evidence for a new basic mechanism in the control of heart rate.
    Tytuł polski: Tlenek azotu stymuluje tworzenie bodźców w węźle zatokowo-przedsionkowym przez aktywację nieznanego dotychczas szlaku sygnałowego: przegląd dowodów z badań in vitro i in vivo na istnienie nowego podstawowego mechanizmu kontrolujacego rytm serca.
    Autorzy: Musiałek Piotr
    Źródło: Prz. Lek. 2002: 59 (9) s.691-694, il., bibliogr. 36 poz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Recent work has tested the hypothesis that nitric oxide (NO) might play an important role in the control of heart rate (HR) by stimulating cardiac pacemaking in the sino-atrial node (SAN). In isolated guinea-pig SAN cells and atrial preparations, nano-micromolar concentrations of NO donors were shown to elicit a NO-dependent increase of 20-30 p.c. in the beating rate. In the pig heart in situ, topical No donor application to the SAN increased HR by ca. 10 p.c., indicating that the direct postiive chronotropic effect of NO is relevant in vivol Indeed, a similar significant increase in HR (by 12 p.c.) was seen in humans with intravenous NO donor infusion while blood pressure was clamped. Inhibition of NO synthase or depletion of its gene have been associated with a significant reduciton in HR by ca. 10 p.c. in vitro and in vivo, consistent with a tonic positive chronotropic effect of endogenous NO. The direct stimulatory effect of NO on cardiac pacemaking is mediated by stimulation of the 'pacemaker' current If in SAN cells via a novel cascade involving cGMP, PDE3-PKA signalling and mobilizaton of intracellular calcium. In conclusion, recent studies have demosntrated for the first tiem that NO exerts a direct positive chronotropic effect through the activationof a novel signal transduction pathway in SAN cells. Evidence in animals and in humans indicates that direct stimulation of cardiac pacemaking by No is functionally relevant for the cotnrol of HR in vivo.


    2152/2523

    Tytuł oryginału: Characteristics of patients with sinus node dysfunction.
    Tytuł polski: Charakterystyka pacjentów z dysfunkcją węzła zatokowego.
    Autorzy: Snezhitsky Victor
    Źródło: Prz. Lek. 2002: 59 (9) s.709-710, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie


    2153/2523

    Tytuł oryginału: Preliminary cardiological examinations in deaf children.
    Tytuł polski: Wstępne badania kardiologiczne dzieci głuchych.
    Autorzy: Rokicki Władysław, Markiewicz-Łoskot Grażyna, Michalewska Aleksandra, Włudarczyk Witold, Mizia Magdalena
    Źródło: Prz. Lek. 2002: 59 (9) s.737-739, tab., bibliogr. 4 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • otorynolaryngologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Istnieją pewnej dowody, że dzieci głuche sa w stosunku do całej populacji bardziej zagrożone niebezpiecznymi zaburzeniami rytmu. Przykłądem takiej arytmii jest zespół Jevell-Lange-Nielsen (jedna z chorób należących do "rodziny" zespołu wydłużonego QT). Dzieci te są obciążone wrodzoną głuchotą, a w zapisie EKG stwierdza sie wydłużenie odstępu QT. Celem pracy było wstępne badanie kardiologiczne 162 głuchych dziec, w tym 76 dziewczynek i 86 chłopców, w wieku 3-15 lat (średnio 10,5 ń 2,8), podopiecznych Zespołu Szkolno-Przedszkolnego dla Dzieci Niesłyszących i Słabo Słyszących. Dane wykorzystane w naszej pracy zaczerpnieto z dokumentacji szkolnej i ankiety rozesłanej do rodziców. pod uwagę wzięto też wyniki badania fizykalnego, ze specjalnym uwzględnieniem układu krążenia, wynik dwukrotnego pomaru ciśneinie krwi i rutynowego zapisu elektrokardiograficznego. W badanej grupie 90 dzieci (55,5 proc.) obarczonych było głuchotą wrodzoną. Wśród tych dzieci u 24 stiwerdzono także w zapisie EKG tachykardię, a u 4 - bradykardię. Blok przedsionkowo-komorowy Iř wykazano u 3 dzieci, u 44 badanych niepełny blok prawej gałązki pęczka Hisa (RBBB), u 1 dziecka blok prawej gałązki był pełny. SKorygowany odstęp QT (QTc) przekraczał graniczną wartość 0,44 sekundy u 12 dzieci obarczonych wrodzoną głuchotą. W całej grupie dzieci głuchych z różnych powodów stwierdzono wydłużenie odstępu QTc u 16 choyrhc. Na podstawie dokumentacji lekarskiej, badania fizykalnego i standardowego zapisu EKG z 12 ...

    Streszczenie angielskie: There is some evidence that deaf children are more threatened than the general population by dangerous heart arrhythmias. An example is Jervell-Lange-Nielsen syndrome (one of the forms of long QT syndrome) which is characterised primarily by congenital deafness and prolongation of the QT interval. The aim of this study was to perform preliminary cardiological examinations on 162 deaf children (76 girls and 86 boys, 3-15 years old, mean age 10.5 ń 2.8 years) who attend the Regional School Centre for Deaf Children in Katowice. The data in our analysis was obtained from case histories (school records and speical questionnaires sent to parents), physical examinations with special regard to the cardiovascular system, double blood pressure measurement and 12 lead surface electrocardiogram. In the studied group, 90 children (55.5 p.c.) were congenitally deaf. Within this group, 24 children manifested tachycardia while 4 children manifested - bradycardia. AV block of I degree was found in 3 children. Incomplete right bundle branch block (RBBB) was observed in 44 children while a complete RBBB was noticed in 1 child. QTc interval ws prolonged (. 0.44s) in 12 children suffering from congental form of deafness and in 16 children suffering from all causes of deafness. On the basis of case history, physical examination, and standard 12-lead electrocardiogram, we established the occurrence of risk factors according to the new diagnostic crieteria of Schwartz et al. with relative ...


    2154/2523

    Tytuł oryginału: Circadian heart rate variability in patient with primary arterial hypertension.
    Tytuł polski: Cykliczna zmienność częstości rytmu serca u pacjentów z pierwotnym nadciśnieniem tętniczym.
    Autorzy: Kolasińska-Kloch Władysława, Furgała Agata, Banach Tomasz, Laskiewicz Janusz, Thor Piotr J.
    Źródło: Prz. Lek. 2002: 59 (9) s.752-755, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie polskie: Wprowadzenie: Zaburzenia autonomicznego układu nerwowego (ANS) są jedną z przyczyn pierwotnego nadciśnienia tętniczego. Mało wiadomo jednak na temat wpływu inhibitorów konwertazy angiotensyny (ACEI), stosowanych w terapii nadciśnienia na jego aktywność. Celem badania była ocena cyklicznej dobowej zmienności parametrów HRV u chorych z pierwotnym nadciśnieniem tętniczym, po roku leczenia inhibitorem konwertazy angiotensyny. Metodyka: Do badania zakwalifikowano 14 chorych z pierwotnym nadciśnieniem tętniczym, z różnicą dzienno-nocną ciśnienia tętniczego powyżej 10 proc. (dippers), w wieku 26 do 61 lat (średnia: 52,9 ń 9,2) oraz 14 zdrwoych ochotników, dobranych pod względem płci i wieku. U badanych chorych wykonano 24-godzinny pomiar ciśnienia tętniczego, z równoczesną rejestracją EKG metodą Holtera. Pacjentów oceniano przed i po roku przyjmownania inhibitora ACE (enalaprilu). Analiza HRV została przeprowadzona w oparciu o szybką transformację Fourierowską (FFI). W badanych grupach poró nywano parametry czasowej i częstotoliwościowej HRV w ciągu dnia oraz w nocy. WYniki: WYniki uzyskane u zdrowych ochotnikó wykazywały nocny wzrost średniej wartości parametrów: RMSSD, pNN50 (p 0,05), TP, VLF, LF i HF (p 0,05) oraz obniżenie wartosci stosunku LF/HF (p 0,05). U chorych przed leczeniem wartosci parametrów analizy czasoej i częstotliwościowej HRV były znamiennie niższe niż w grupie kontrolnej. Podobną tendencję obserwowano po roku stosowania enalaprilu. Po roku ...

    Streszczenie angielskie: Introduction: Abnormalities of autonomic nervous system function (ANS) exist in patients with hypertension and have been considered as one of the important factors in developing of essential hypertension. However the information about the effect of antihypertensive treatment (angiotensincoverting enzyme inhibitors - ACEI) on cardiac ANS activity is scarce. The main aim of our study was to evaluate circadian heart cate variability changes in primary hypertension treated with ACE inhibitors. Methods: Fourteen patients with essential hypertension with night/day differences of mean blood pressure of more than 10 p.c. (dippers) aged 26 to 61 years (mean 52.9 ń 9.2) and 14 healthy volunteers, 14 healthy volunteers were recruited and matched for age and gender. Ambulatory 24 hour arterial blood pressure measurement using HoICARD (Aspel, Poland) recorder with simultaneous ECG monitoring using the MediarcPremier IV Holter Monitoring System (DRG-International) (DRG_International) undertaken in both groups of patients. The hypertensive patients were tested before and after one year of the enalaprii treatment. The HRV analysis was performed according to a standard Fast Fourier Transformation (FFT). THe time and spectral analysis parameters were compared within the examined groups of patients during day and night. Results: The results obtained in the control group showed the greate circadian fluctuations in sympathetic and parasympathetic activity. A simultaneous circadian HRV ...


    2155/2523

    Tytuł oryginału: Arterial hypertension in children treated at the Katowice Department of Pediatric Cardiology between 1993-2000.
    Tytuł polski: Nadciśnienie tętnicze u dzieci leczonych w latach 1993-2000 w katowickiej Klinice Kardiologii Dziecięcej.
    Autorzy: Rokicki Władysław, Skierska Agnieszka, Bilewicz-Wyrozumska Teresa
    Źródło: Prz. Lek. 2002: 59 (9) s.759-761, tab., bibliogr. 20 poz., sum.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • pediatria

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie polskie: W piśmiennictwie można znaleźć częstą opinię, że 1-3 proc. populacji dziecięcej ma nadciśnienie tętnicze. Wartość ta zależy od przyjętego kryterium rozpoznania i badanej populacji (wiek, płeć, rasa, itp.). Celem naszej pracy było przedstwienie licznej grupy 271 pacjentów leczonych z powodu nadciśnienia w naszym ośrodku w latach 1993-2000. Były to dzieci od wieku noworodkowego aż do 18 lat (średnia wieku = 13,75 ń 4,5 lat). W okresie badań można badań można było zauważyć prawie czterokrotny wzrost rocznej liczby chorych z nadciśneiniem wśród wszystkich pacjentów klinki. Na podstawie naszego materiału można stwierdzić jak bardzo występowanie nadciśneinia zależy od wieku dzieci. Aż 3/4 naszych pacjentów stanowiły nastolatki w wieku równym lub przekraczajacym 14 lat. W grupie nastolatków zawarte też były wszystkie przypadki nadciśnienia samoistnego. Prawie 70 proc. badanych dizeci to chłopcy. U połowy opisywanych chorych istniały zmiany typowe dla nadciśnienia na dnie oka. Można sądzić, że 24-godzinny automatyczny pomiar ciśnienia tętniczego (tzw. Holeter ciśneiniowy) ma dużą wartość u dzici. Liczba pomiarów przekraczających normę w czasie Holtera ciśneiniowego korelowałą z obecnością zmian naczyniowych na dnie oka. Autorzy konkudują, że nadciśnieniu należy poświęcić więcej uwagi w populacji pediatrycznej. Np. w naszej poprzedniej pracy, ogłoszonej w 2000 roku wykazano, że u 2,3 proc. szkolnych dzieci z nadciśnieniem choroby ta nie była wcześniej podejrzewana.

    Streszczenie angielskie: In the literature, one can find a common opinion that 1-3 p.c. of the children population suffers from arterial hypertension. This rate depends on the diagnostic criterion and the studied population (age, sex, race etc). The aim of this work was to present a rather alrge group (271 patients) treated for hypertension in our centre between 1993-2000. The ranged children from newborns to 18 year olds (mean = 13.75 ń 4.5 years). In the study period, there is approximately a four fold annual increase in the number of hypertensive patients among all patients of the pediatric cardiology units. On the basis of our material, the rate of arterial hypertension depends on the age of the pediatric patients with as many as 3/4 of the children being teenagers ň 14 years old. In the teenager group, all cases of essential hypertension were observed. Almost 70 p.c. of the studied children were boys. In about half the studied group, hypertensive changes on the eye fundus were found. One can suspect that automatic 24-hour measurement of arterial hypertension (so called "tension Holter") is of great value in chidlren. A number of individual measurements exeeding the norm during "tension Holter" correlated with eye fundus vessel changes. In conclusion more attention should be paid to arterial hypertension in children. For example, in our previous paper published in 2000 it was stated that among 2.3 p.c. of "healthy" school children who suffered from arterial hypertension, non of these children were suspected of suffering from arterial hypertension.


    2156/2523

    Tytuł oryginału: Development of a simple screening system for endocrine disruptors.
    Autorzy: Sugawara Teruo, Nakajima Ayako, Nomura Eiji
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR431-BR438, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • endokrynologia
  • toksykologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Background: An endocrine disruptor is a synthetic chemical, which casuses adverse effects in an organism, or its progeny, after causing perturbations in the endocrine system. It is important to know which synthetic chemicals have endocrine-disrupting action. However, an increasing nubmer of synthetic chemicals are being produced by modern synthetic chemistry, and the examination of endocrine disruptor potential has not yet caught up with the advances in synthetic chemistry. In this study, we have devveloped such a screening system for detecting synthetic chemicals iwth estrogen-like effects. Materia/Methods: The system was based on teh yeast one-hybrid system. Both HIS3 and lacZ reporter genes connected to three tandem copies of the estrogen response element were prepared. Gal4-estrogen receptor is a fusion protein made from the activation domain (AD) of the yeast GAL4 transactivator gene and then incorporated into a plasmid, which was transfected into the YM-4271 yeast cell strain. The estrogen effect was judged by this developed screening system. Results: A dual reporter assay-system was established by transfectio of the both HIS3 and lacZ reporter genes into the yeast cells. THis screening system enabled the detection of as little as 10**-12 mol of á-estradiol. Conclusion: These resutls show that this newly developed dual assay is useful for the screening of endocrine-disruptors that have estrogen-like action.


    2157/2523

    Tytuł oryginału: Immunostimulatory effect of Silybum Marianum (milk thistle) extract.
    Autorzy: Wilasrusmee Chumpon, Kittur Smita, Shah Gaurang, Siddiqui Josephine, Bruch David, Wilasrusmee Skuntala, Kittur Dilip S.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR439-BR443, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: Background: Herbal products are increasingly used for their effects on the immune system. Milk Thistle, a commonly used herbal product is known to inhibit growth of certain tumors, although the mechanism of this effect remains unknown. Previously we have shown that Milk Thistle extracts stimulate neurons in culture. Since other drugs that affect the neuronal system also affect the immune system, we investigated the effects of Milk Thistle on the immune system. Material/Methods: Standardized Milk Thistle extract was studied in murine lymphocyte proliferation tests using Concanavalian A (ConA) as the mitogen for non-specific stimulation and mixed lymphocyte culture (MLC) as allospecific stimulation. Th1 and Th2 cytokine levels in MLC were assayed by two antibody capture ELISA technique. ALl tests were performed in triplicate and repeated twice. Reults: We found that Milk Thistle is immunostimulatory in vitro. In increased lymphocyte proliferation in both mitogen and MLC assays. These effects of MIlk Thistle were associated with an increase in interferon gamm, interleukin (IL-4) and IL-10 cytokines in the MLC (table). This immunostimulatory effect increased in response to icnreasing doses of Milk Thistle. Conclusions: Our study has uncovered a novel effect of milk thistle on the immune system. This immunostimulatory effect may be of benefit in increasing the immunity to infectious diseases.


    2158/2523

    Tytuł oryginału: The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia nad reperfusion in the rat.
    Autorzy: Mota-Filipe Helder, Sepodes Bruno, McDonald Michelle, Cuzzocrea Salvatore, Pinto Rui, Thiemermann Christoph
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR444-BR453, il., tab., bibliogr. 42 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: This study was designed to investigate the effects of 5-aminoisoquinolinone (5 -AIQ), a watersoluble potent inhibitor of poly-(ADP-ribose) polymerase (PARP) in a rat model of liver ischemia-reperfusion injury. Material/Methods: Male Wistar rats were anesthetised with sodium pentobarbital (60 mg/kg, i.p.) and subjected to liver ischemia (for 30 minutes) and reperfusion (for 2 hours). Liver injury was assessed by measuring (i) the serum levels of transaminases, lactate dehydrogenase, ç-glutamyl transferase, (ii) lipid peroxidation in liver tissue and (iii) by immunohistochemistry for PARP and intracellular adhesion molecule 1 (ICAM-1). Resutls: Pre-treatment of rats (five minutes prior to onset of liver ischemia) with the PARP inhibitor 5-AIQ (3 mg/kg, i.v.) rather than vehicle reduced the rise in the serum levle sof transaminases, lactate dehydrogenase, and ç-glutamyl transferase as well as the degree of lipid peroxidation (measured as levels of malondialdehyde in the liver) caused by ischemia-reperfusion of the liver. Liver secitons obtained from 5-AIQ treated rats showed reduced PARP activation and less staining for ICAM-1. Conclusions: Taken together, these results show that 5-AIQ, a new water-soluble potent inhibitor of poly(ADP-ribose) polymerase, reduces the tissue injury associated with ischemia-reperfusion of the liver. we propose that 5-AIQ may be useful in the therapy conditions associated with ischemia-reperfusion of the liver which remains an important clincal problem during shock, liver surgery, and liver transplantation.


    2159/2523

    Tytuł oryginału: Uric acid is a main electron donor to peroxidases in human blood plasma.
    Autorzy: Padiglia Alessandra, Medda Rosaria, Longu Silvia, Pedersen Jens Z., Floris Giovanni
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR454-BR459, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Background: Peroxidases are widely distributed and have been isolated from many higher-order plants, animal tissues, yeast and microorganisms. During measurements of peroxidase activities in samples of human plasma, we noticed the presence of a compound in the plasma which was interfering with the peroxidase assay. In this paper we describe the purification and characterization of this factor, which was identified as uric acid. Material/Methods: The procedure used to purify uric acid from plasma involved ultra-filtration of the plasma, heat denaturation, DEAE-cellulose chromatography, and high performance liquid chromatography. The lyophilized powder was tested for homogeneity using an HPLC apparatus and capillary electrophoresis. Genuine uric acid samples were used for comparison. Results: The compound obtained by the above-reproted purification procedure was identified as uric acid by spectrophotometric analysis through comparison with genuine uric acid samples. Spectrophotometric measurements indicated that uric acid was degraded by HRP in the presence of H2Os. Conclusion: The experimental procedures described above allowed us to isolate and identify uric acid as the component in human plasma that acts as a true substrate for peroxidases.


    2160/2523

    Tytuł oryginału: Functional consequences of the in-frame insertion of a transposon into the mutated gamma amino butyric acid transporter of Saccharomyces cerevisiae.
    Autorzy: Naghibalhossaini Fakhraddin, Nault Francine, Saragovi Uri, Nedev Haynu, Johnstone Rose M.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR460-BR470, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: Background: The Saccharomyces cerevisiae strain, 22574d, lacks gamma amino butyric acid (GABA) transport activity and cannot grow on this amino acid as sole nitrogen source. Both transport of and growth on this amino acid are restored when the yeast is transformed iwht a form of mouse gamma actin containing an extended C-terminal sequence (mç-A). The nature of the mutation in the transporter as well as the complementation mode are addressed. Materia/Methods: The cDNA sequence of the mutated transporter was achieved using reverse transcription, 3'- Race and cloning. For detection, Northern blotting and labeling with 32-P were used. THe putative ability of the transporter to interact with gamma actin in vivo was examined by following the interaction in vitro of synthetic peptides corresponding to the C-termini of the gamma actin and the transporter. Resutls: Up to codon 394 the mutated an native transporters are identical. At the 3' end, the mutant is by extended by 32 codons from the delta region of a Tyl transposon, giving an open reading frame of 426 codons, and a predicted structure of 9 of the 11 transmembrane domains. Peptides correspoding to the carboxy terminal regions of the truncated transporter and the elongated species of gamma actin show the potential to interact in vitro. Conclusion: The mutated GABA transporter mRNA contains an insert from the delta region of a Tyl transposon. This insertion allows expression of a transporter capable of itneracting with elongated gamma actin to rehabilitate the transporter.


    2161/2523

    Tytuł oryginału: Dynamic changes in cellular immune responses in experimental bovine tuberculosis.
    Autorzy: Joardar Siddhartha N., Ram Gulab C., Goswami Tapas K.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR471-BR480, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • bydło
  • płeć męska

    Streszczenie angielskie: Background: The development of T-cell responses in natural hosts, such as cattle, would be a useful model of tuberculosis to investigtate the changing pattern of T-cell responses and mycobacterial antigens recognized along with the progression of the disease. Material/Methods: The present study was undertaken to characterize immune-effector cells and cytokines in Mycobacterium bovis AN5-sensitizaed cattle, from day 0 to 45 weeks post inoculation (PI). In vitro lmphoproliferation, cytotoxic T lymphocyte (CTL) response, and cytokine release pattern (viz. IL-2, IFN-ç) from activated PBMC were assessed throughout the spectrum. THe effort was made to identify various T-cell target antigens during different post sensitization stages, using T-cell imunoblotting. Results: Cell-mediated immune (CMI) responses were very high between the 9th and 20th week PI. THe early appearance of çë+ T-cells was followed by the predominance of CD4+ T-cells, and finally CD8+ T-cells until the 20th week PI. Lymphocyte-effector activity in terms of lymphoproliferation and CTL responses were quite evident between the 9th and 20th weeks PI an aroudn the 12th week PI, respectively. Certain immunodominant polypepetides of culture filtrate preparation of molecular weights 72-74, 30-32, 25 and 22-24 kDa induced higher lymphoproliferation and CTL responses. THe kinetics of in vitro cytokine release (IL-2 and iFN-ç) from PBMC showed a definite trend in a ll M. bovis AN5-sensitized cattle, with a highe concentration between the 9th and 20th weeks PI. Conclusions: The present investigation revealed some basic aspects of the immune -effector mechanism pertaining to bovine tuberculosis.


    2162/2523

    Tytuł oryginału: Preparation and characterization of two new composites: collagen-brushite and collagen octa-calcium phosphate.
    Autorzy: Jayaraman Mythili, Subramanian Manicka Velayudham
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.BR481-BR487, il., bibliogr. 37 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • in vitro
  • bydło

    Streszczenie angielskie: Background: Recent studies have focussed on understanding the fundamental aspects of mineralization, searching for insight into the physical and chemical interactions between the organic and inorganic counterparts in bio-inorganic composites. Structural alterations in organic matrices interacting with minerals during the phase transition form un-calcified to calcified affect the mineral micro-environment, resulting in calcification. The present study deals with the fabrication of two novel bio-inorganic composites: collagen-brushite and collagen-octacalsium phosphate. The mineral conterparts are grown onto collagen by crystal growth, to produce composites adaptaed to the ambient environment in bone, at pH 5.8 and pH 7.0. The biophysical and material characteristics provide some interesting insights into calcifying mechanisms. Matiral/Methods: The biophysical parameters were evaluated by Fourier Transform Infra Red (FTIR) spectroscopic studies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopic (SEM) studies, with biochemical characterization of demineralized and remineralized samples for hydroxyproline, hexosamine, uronic acid, and net protein content. Results: THe biochemical characterization of demineralized and remineralized samples revealed protein loss on mineralization and indicated the possible role of non-collagenous proteins (osteonectin) in mineralization. The FTIR spectra showed loss of amide peaks, while DSC and SEM studies showed closer association of collagen with the mineral counterpart...


    2163/2523

    Tytuł oryginału: Urine microalbumin excretion in relation to exercise-induced electrocardiographic myocardial ischaemia.
    Autorzy: Waldron Julian S., Baoku Yetunde, Hartland Andrew J., Anderson Neil R., Horton Richard C., Gama Rousseau
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR725-CR727, tab., bibliogr. 7 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Microalbuminuria, a marker of endothelial cell dysfunction, is associated with atherosclerosis and is a predictor of coronary heart disease. It has been suggested that patients with coronary heart disease have exaggerated exercise-induced urinary microalbumin excretion but this is controversial. We, therefore, measured urine microalbumin excretion in men before and after an exercise electrocardiogram. Material/Methods: Urine microalbumin excretion expressed as the albumin-creatinine ratio (ACR) was measured before and after an exercise electrocardiogram in 10 subjects with exercise-induced myocardial ischaemia and 14 subjects without exercise-induced myocardial ischaemia. Results: In subjects with a positive exercise electrocardiogram, the pre-exercise electrocardiogram ACR 3.3 ń 5.50; (mean ń SD) significantly increased (p = 0.0371) follwoing exercise (6.30 ń 10.25). In subjects with a negative exercise electrocardiogram, the pre-exercise electrocardiogram ACR (0.73 ń 0.52) also significantly increased (p = 0.0295) following exercise (2.04 ń 1.81). Pre-exercise ACR was higher (p = 0.0164) in subjects with a positive exercise electrocardiogram (3.3 ń 5.50) than in those subjects with a negative exercise electrocardiogram (0.73 ń 0.52). Incremental and post-exercise ACR were not significantly different in those with normal and abnormal exercise electrocardiograms. Conclusion: Patients with exercise-induced myocardial ischaemia have pre-exercise urine microalbumin excretion. Exaggerated uring microalbumin excretion in resposne to exercise is not associated with exercise-induced myocardial ischaemia.


    2164/2523

    Tytuł oryginału: Laypersons' expectation of the sequelae of whiplash injury. A cross-cultural comparative study between Canada and Lithuania.
    Autorzy: Ferrari Robert, Obelieniene Diana, Russel Anthony Science, Darlington Paul, Gervais Roger, Green Paul
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR728-CR734, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The objective of the present study is to compare the frequency and nature of expected 'whiplash' symptoms in Lithuania (a country where the late whiplash syndrome is rare or unknown) with that in Canada. Material/Methods: A symptom checklist was administered to 2 subject groups selected from local companies in Kaunas, Lithuania, and Edmonton, Canada, respectively. Subjects were asked to imagine having suffered a neck sprain (whiplash injry) with no loss of consciousness in a motor vehicle accident, and to check which, of a variety of symptoms, they would expect might arise from the injury. For symptoms they anticipated, they were asked to select the period of time they expected those symptoms to persist. Results: In both the Lithuanian and Edmontonian groups, the pattern of symptoms anticipated closely resembled the acute symptoms commonly reported by accident victims with acute neck sprain, but while up to 50 p.c. of Edmontonians also anticipated symptoms to last months or years, very fe Lithuanian subjects selected any symptoms as likely to persist. Conclusions: In Lithuania, despite the documented occurrence of neck sprain symptoms in some 50 p.c. of individuals following motor vehicle accidents, there is a very low rate of expectation of any sequelae from this injury. What current or previous aspects of society that underlie this remain uncertain. This lack of expectation of chronicity in Lithuania may, in part, determine the low prevalence of the late whiplash syndrome there. Further sutdies of symptom expectation as an etiologic factor in the late whiplash syndrome are needed.


    2165/2523

    Tytuł oryginału: The effect of perendoscopic sclerosing agent injection in Forrest's II ulcers - a pilot study from Turkey.
    Autorzy: Saruc Murat, Ozden Nuri, Kucukmetin Nurten, Tuzcuoglu Isil, Yuceyar Hakan
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR735-CR739, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Bakcground: We aimed to clarify the outcome of perendoscopic prophylactic injection of sclerosing agent in Forrest's II ulcers. Material/Methods: Patients with upper gastrointestinal bleeding in last 6 hours were performed emergency endoscopy and were enrolled. The patients in group-1 were performed prophylactic injection therapy with 1 p.c. aethoxyclerol and then given medical treatmetn with intravenous 40 mg omeprazole twice a day and somatostatin infusion at the dose of 6 mg/day during 3 days. Group-2 patients were only given medical treatment with same agents and at same doses without having any perendoscopic therapy. Results: There were 32 pateitns in group-1 and 20 in group-2. In emergency endoscopy, 20 (62.5 p.c.) patietns had IIa ulcers and 12 (37.5 p.c.) patients had IIb ulcers in group-1. These patients underwent prophylactic perendoscopic hemostasis by 1 p.c. aethoxysclerol in addition to medical treatment. Early rebleeding occurred in 9 (28.1 p.c.) patients of group-1 and 3 (15 p.c.) in group-2 (p 0.001). At the endoscopic control after 48 hours 13 (40.6 p.c.) patients in the group-1 and 15 (75 p.c.) patients in group-2 showed improved local ulcer stigmata (p 0.001). The numbers of blood units transfused were lower in the group-2 (p = 0.002). THe hospital stay was longer in group-1 (p = 0.01). In the group-1, more endoscopic intervention was needed. Any death and the need for surgical intervention did not occurred in any groups. Conclusion: According to our resutls; the indication of perendoscopic prophylactic injection of sclreosing agent in non-bleeding ulcers with high risk of rebleeding must be reviewed by large population based, prospective, randomized trials.


    2166/2523

    Tytuł oryginału: Predictors of change in exercise capacity after comprehensive COPD inpatient rehabilitation.
    Autorzy: Cilione Carmela, Lorenzi Cristina, Dell'Orso Daniela, Garuti Giancarlo, Rossi Giuseppina, Totaro Lina, Clini Enrico
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR740-CR745, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In order to evaluate the factors associated with change in exercise capacity after comprehensive inpatient Pulmonary Rehabilitation (IPR) we studied 132 consecutive adults with Chronic Obstructive Pulmonary Disease (COPD) recovering from an acute exacerbation. Material/Methods: Lung function, arterial blood gases, and respiratory muscle strength were measured at baseline. Perceived breathlessness (B), 6-minute walk distance (6MWD) dyspnea at rest and postexertion (D), hospital anxiety and depression (HAD), and health-related quality of life were assessed before (T0) and after (T1) IPR. The patients were divided into two groups depending on the change in 6MWD: Improvers (IM at least +54 meters after IPR, n = 81) or Non-Improvers (NIM less htan 54 meters or no change, n = 51). Results: At T1 61 p.c. of the patients showed improvement as here defined. The IM group showed lower 6MWD and higher B and resting-D at T0than NIM (p 0.05). A stepwise multiple regression analysis was performed using 6MWD change as the dependent variable and anthropometric and physiological measures at T0 as the independent variables. This regression model explained 26 p.c. of the 6MWD-change; 6MWD and PaO2 significantly contributed to this model. Conclusions: In COPD patients recovering from an acute exacerbation, the predicted change in exercise capacity using anthropometric, demographic, clinical, and physiological variables after 2 weeks of comprehensive IPR is likely to be low. The baseline level of exercise performance and arterial oxygenation who the most consistent correlation with change in walking ability in these patients.


    2167/2523

    Tytuł oryginału: Brief chewing of Garcinia manii stick reverses reduced saliva pH after a glucose rinse.
    Autorzy: Addai Frederick Kwaku, Nuamah Isaac Kwasi, Parkins Grace E. A.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR746-CR750, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Bakcground: A popular variety of wood, pieces of which are chewed as an oral hygiene practice in Southern Ghana, was tested for its capacity to reverse experimentally lowered pH of saliva. This was done to determine whether (Garcinia manii) stick-chewing neutralises acideogenic challenge to teeth, and thereby potentially affords dental caries prevention benefit. Material/Methods: Seventy-two volunteer medical students gave (baseline) saliva samples by spitting 3-4 times into a 25 ml conical flask. They then rinsed their mouths with a five-percent aqueous solution of glucose. Subsequent to the glucose rinse, half of the subjects (cheweres), pre-selected by drawing lots, chewed a popular chewing stick Garcinia manii for five minutes, while the other half (controls) did not. The pH of saliva samples given by the volunteers at various time intervals was measured using a Kent EIL 7020 pH meter, and the results were analysed by the ANalysis of Variance (Anova) method. Results: As expected, saliva pH was reduced in both grops after the glucose rinse, but increased significantly faster in stick cheweres compared with controls. Conclusion: It is suggested from this study that brief (Garcina manii) stick-chewing confers a caries prevention/control benefit by reversing acidogenic challenge to teeth.


    2168/2523

    Tytuł oryginału: Reversed circadian rhythms of heart rate variability and morning peak occurrence of sustained ventricular tachyarrhythmias in patients with implanted cardioverter defibrillator.
    Autorzy: Fries Roland, Hein Sandra, K”nig Jochem
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR751-CR756, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Bakcground: It is generally supposed that diurnal fluctuations of heart rate variability (HRV) are associated with durinal variability of occurrence of sudden cardiac death, usually caused by tachyarrhythmias. To date, however, there have been no data comparing circadian rhythms of HRV and circadian variability of malignant ventricular tachyarrhythmias in the same patients. Material/Methods: We studied 20 consecutive recipients of implantable cardioverter defibrillators in long-term follow-up, comparing the circadian rhythms of HRV in patients with and without typical morning peak occurrence of ventricular tachyarrhythmias. Results: The HRV marker of vagus activity (RMSSD and HF power) displayed physiological circadian variability (Highest values during sleep time, morning dip) only in patients without morning peak of arrhythmic events, adn inverse circadian variability in patients with tachyarrhythmic morning peak. THe variations in LF power and LF/HF ratio in both groups were not statistically significant, but with respect to the time interval between midnight and noon again showed inberse diurnal variation in patients with and without morning peak of arrhythmic events. Conclusions: These data suggest an association between a reversed circadian rhythm of HRV and morning peak frequency of tachyarrhythmic events in patients with ICD. As pronounced adrenergic hyperactivity in heart failure is the probable reason for paradoxically reversed circadian HRV variation, this association supports the hypothesis that the morning peak frequency of cardiovascular events may be interpreted as a sign of cardiovascular overload by the natural change from sleep to activity after awakening.


    2169/2523

    Tytuł oryginału: Palmar and digital dermatoglyphics of indigenous black Zimbabweans.
    Autorzy: Igbigbi Patrick S., Msamati Boniface C.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR757-CR761, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dermatoglyphic traits have been shown to be genetically determined, conservative in their evolution, and different between and within population groups. There have been a few reports dealing with SOuthern African populations, but there appears to be no published report for indigenous black Zimbabweans. Material/Methods: Bilateral palmar and digital prints of 270 indigenous black Zimbabweans were recorded, studied and classified using standard methods. The total finger ridge count (TFRC), pattern intensity index (PII), atd angle, and a-b ridge counts were analyzed and the data compared with those of Malawians, South African Zulus and Nigerian Yorubas. Resutls: Ulnar loops were the most predominant digital pattern type in both sexes followed by whorls in males and arches in females. Females had significantly higher atd angles than males (p 0.01). Significant differences were also demonstrated between Zimbabwean and Malawian females, and between Zimbabwean and Yoruba men in TFRC and a-b ridge counts. Similarly significant differences were observed between ZImbabwean and Malawian males, male ZImbabweans and Yoruba, and male Zulus and Yorubas in atd angle and a-b ridge counts (p 0.001). Conclusion: This study documents similariteis in digital ridge patterns between Zimbabweans, Malawians, and to some extent South African Zulus, indicating their close historical and anthropological relationship. However, ZImbabweans could be differentiated from the other population groups using certain dermatoglyphic triats. Nevertheless, all the groups showed some features common to other black Africans.


    2170/2523

    Tytuł oryginału: Prevalence of markers of hepatotropic viruses A, B, C and the efficacy of vaccination against hepatitis A and hepatitis B among medical students.
    Autorzy: Jabłkowski Maciej, Kuydowicz Jan, Strzelczyk Janusz, Białkowska Jolatna
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR762-CR766, tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hepatitis A and B can be prevented by active immunization. The purpose of our study was to estimate the prevalence of viral markers of hepatitis A, B, and C among medical students, to assess the efficacy of vaccination against HBV infection after 4 years, and to evaluate the efficacy of vaccination against HAV infection. Material/Methods: The study group consisted of 150 medical students, who were vaccianted with ENgerixtm B at the beginning of medical studies. From this population we identified a subgroup of 45 students, in whom the presence of anti-HAV was not confirmed; they were then vaccinated with HAVRIXtm 1440. Viral markers for HAV, HBV, HCV were determined in this group. Results: In the group of 150 persons, we found anti-HBc in 8 students (5.3 p.c.), and HBsAg in 1 (0.7 p.c.), who did not have either HBeAg or anti-HBe. Anti-HBs antibodies were found in 146 students (97.3 p.c.); anti-HCV in 3 cases (2 p.c.), and anti-HAV in 15 cases (10 p.c.). After 2-fold vaccination against viral hepatitis A, 100 p.c. of the students presented with anti-HAV. Conclusion: The incidence of HBsAg and anti-HCV among our students is the same as in the general population, while the incidence of anti-HAV is much lower (10 p.c.). The presence of anti-HBs 4years after vaccination was detected in 97.3 p.c. of the students, and anti-HAV 1 month after the complete course of vaccination in 100 p.c. of cases.


    2171/2523

    Tytuł oryginału: Diversity of clinical symptoms in A3243G mitochondrial DNA mutation (MELAS syndrome mutation).
    Autorzy: Pronicki Maciej, Sykut-Cegielska Jolanta, Mierzewska Hanna, Tońska Katarzyna, Karczmarewicz Elżbieta, Iwanicka Katarzyna, Bartnik Ewa, Pronicka Ewa
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR767-CR773, tab., bibliogr. 42 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: MELAS (mitochondrial myopathy, lactic acidosis and stroke-like episodes) is one of the most common mitochondrial encephalomyopathies. Material/Methods: We present four children wtih A32343G MELAS mtDNA mutation and give a summary of clinical MELAS symptoms reported in the literauter. Serum lactate elevation, mosaic pattern of COX deficit and decreased activity of complex I and IV in the muscle biopsy were found in all cases. RRFs were recognized in three our of four. Results: The main features seen in all ur patients were poor growth and fatigability with muscle weakness. All presented epileptic jerks of various character, some deformation features (recurrent pretibial and peritarsal edema, large swollen-looking hands and feet, hypertelorism and protruding ears) and some cutaneous lesions( atopic dermatiits, local melanoderma, asymmetric vascular dilatation). Stroke-like episodes, multihormonal hypopituitarism, sensorineural hypoacusis, pigmentary retinal degeneration, intracranial calcification, heart involvement, recurrent vomiting or abdominal pain were seen only in individual cases. THe homonymous hemianopia frequently reported in the literature was not a feature of our patient. One of them suffered from nonspecific sialoadenitis never mentioned in the literature. Conclusion: Morphological, enzymatic and molecular investigations of a muscle biopsy sample should be undertaken to improve early MELAS detection in patients with any multiorgan disease associated with serum lactate elevation.


    2172/2523

    Tytuł oryginału: Clinical and bacteriological results from the administration of Cefepime (Maxipime) in patients with severe sepsis.
    Autorzy: Stefanov Chavdar Stefanov, Doikov Ilian, Dimov Rossen, Deenichin George, Delikostadinov George
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.PI97-PI102, il., tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the present study was to investigate the clinical and bacteriological efficacy of Cefepime administered to critically ill sepsis patients, as well as possible adverse reactions and interactions. Material/methods: 30 patients with severe sepsis of different origin were treated with Cefepime a dosage of 2.0 g bid. Of these patients, 26 survived (86.67 p.c.). The clinical and bacteriological effects of antibiotic administration were recorded at the end of treatment. Results: The treatment outcomes in terms of clinical results were as follows: 17 patients cured (56.67 p.c.), 7 improved (23.33 p.c.), 2 with unsatisfacotry outcome (6.67 p.c.), and 4 failures (13.33 p.c.). Cefepime treatment resulted in a reduction of the APACHE II score from ca. 20 at the beginning to 9.44 at the end, while the SOFA score fell from 7 to 2.62. This indicates improved clinical status and reversal of multiple organ failure. The bacteriological results were as follows: pathogen eradication in 17 cases (56.6 p.c.), pathogen persistence in 8 cases (26.67 p.c.), and superinfection in 5 cases (16.66 p.c.) Out of 80 total hemocultuers, 63 proved to be sterile. In two cases in vitro ENterococcus faecium was isolated with antibiotic resistance. Of 81 total cutures of infectious foci 10 showed resistance: 4 Pseudomonas aeruginosa, 4 Acinetobacter baumanii, and 2 Enterococcus faecalis. No side effects of Cefepime administration were recorded. Conclusions: Cefepime adminsitration resulted in low mortality, clincial improvement, minimal resistance, and lack of side effects. Cefepime is an effective drug of first choice for critically ill sepsis patients.


    2173/2523

    Tytuł oryginału: Alcohol induced ketoacidosis, severe hypoglycemia and irreversible encephalopathy.
    Autorzy: Jain Hitender, Beriwal Sushil, Singh Shailender
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR77-CR79, il., bibliogr. 4 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Severe hypoglycemia leading to permanent brain damage is rare in non-daibetic population. We present one such case where chronic alcoholism combined with prologned fasting lead to such a state and patient ended in a persistent vegetative state. Case report: A 50 year old Asian woman with past history of chronic alcoholism and hepatitis C was found unresponsive in her house after drinking alcohol consecutively for 2 days. Finger-stick glucose done by paramedics was 20 mg/dl. She was given 50 ml of 50 p.c. dextrose without any neurological response. On arrival in the emergency department patient was found to be comatose with only withdrawal response to deep painful stimuli and a negative babinski's sign. Computered tomogram of the head revealed mild cerebral atrophy. After an extensive work up a diagnosis of alcoholic ketoacidosis with hypoglycemia related encephalopathy was made. Conclusion: Alcohol induced ketoacidosis is usually associated with normal blood glucose. The probable etiology of low blood sugar in our patient was alcohol-induced inhibition of gluconeogenesis along with starvation. The prolonged hypoglycemia caused cortical damage simulating ischemic brain damage. Ten months in to follow-up patient is still in persistent vegetative state with no noticeable neurological recovery.


    2174/2523

    Tytuł oryginału: Evaluation of an alternative, subclavicular approach to thyroidectomy.
    Autorzy: Akasu Haruki, Shimizu Kazuo, Kitagawa Wataru, Ishii Ritsuko, Tanaka Shigeo
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CS80-CS82, il., tab., bibliogr. 4 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: After presenting with the common finding of a nodular goiter, many patients refuse surgery because of the potential for a conspicuous anterior neck scar. Despite the development of endoscopic approaches to neck dissections, it can be difficult to remove a large thyroid tumor using such approaches. Material/methods: We attempted thyroid lobectomies via a subclavicular approach in three cases - three women whose ages ranged from 36-45 years old. Each patient was diagnosed with a cyytologicallybenign nodular goiter with a diameter greater than 60 mm. Subclavicular incisions were made with the length being determined by the size of teh tumor and with the thyroid bering approached laterally for resection. Results: Despite a maximum tumor diameter of greater than 70 mm, our operative technique was comparable to conventional methods with respect to surgical exposure, safety and operation time. Cosmetically, each patient was satisfied with the post-operative results. Conclusion: We believe that the subclavicular approach to thyroidectomy is a safe and cosmetically-superior alternative to conventional surgery, even in cases that are too large to approach endoscopically.


    2175/2523

    Tytuł oryginału: Acute digital gangrene in a long-term dialysis patient - a diagnostic challenge.
    Autorzy: Piccoli Giorgina Barbara, Quaglia Marco, Quaglino Pietro, Burdese Manuel, Bermond Francesca, Mezza ELisabetta, Jeantet Alberto, Segoloni Giuseppe Paolo
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CS83-CS89, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • nefrologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Vascular complications are frequent in long-term dialysis patients. The differential diagnosis is complex and includes immunological derangement (underlying disease, uremia), vasculopathic-atheroembolic diseases, calciphylaxis, infections, neoplasm, coagulation disorders, and adverse drug effects. Case report: We reprot on a 50-year-old male patient with a long follow-up on renal replacement therapy (20 years), currently on daily hemodialysis. The patient's history of kidney transplantation was complicated by seven acute rejection episodes and by Kaposi sarcoma; comorbidity included HLA-B27 positive ankylosing spondylitis, diffuse vascular disease, recurrent atrial fibrillation, chronic hypotension, HCV positivity. Ten days after the start of warfarin for an atrial fibrillation episode, the patient developed digital necrotising ulcerations, rapidly evolving into partial symmetric digital gangrene at distal phalanxes. The timing and evolution of the lesions and the finding of protein S deficiency were the clues for diagnosing warfarin-induced skin necrosis (WISN); the drug was discontinued and therapy with low-molecular weight heparin, plasma and prostacyclin achieved slow resolution of lesions. Conclusions: According to a combined MEDLINE and EMBASE search, this is the first report of WISN in a hemodialysis patient: underlining the clincial relevance of this uncommon problem, this case exemplifies the difficult differential diagnosis of acute vascular skin lesions in dialysis patients.


    2176/2523

    Tytuł oryginału: Recombinant human activated protein C for severe sepsis in a neonate.
    Autorzy: Rawicz Marcin, Sitkowska Bożena, Rudzińska Iwona, Kornacka Katarzyna M., Bocheński Przemysław
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CS90-CS94, il., bibliogr. 13 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Background: Neonatal sepsis is frequently associated with pathological activation of the coagulation system, leading to multiple organ dysfunciton. Activated protein C has been shown to prevent thrombin generation durign this process and improve microcirculation. Case report: We present the case of a full term septic neonate admitted for tertiary intensive care with multiple organ failrue, including ARDS with severe pulmonary hypertension, renal failure, and disseminated intravascular coagulation. After initial resuscitation with volume expansion, catecholamines, pentoxifylline and nitric oxide, a diagnosis of severe systemic enterococcal sepsis was made and vancomycin-meropenem therapy was started. Because available standard treatment, including platelet transfusion, did not improve the coagulation status, it was decided to give recombinant human activated protein C (drotrecogin alpha Xigris, Elli Lilly, USA - rhAPC) in 24 mcg kg-1úh-1 continuous four-day infusion. Six hours after the start of infusion all coagulation parameters returned to normal. No side effects were observed. Renal function was restored after 36-hr hemofiltration. Treatment success was due to several factors, including resuscitiation form cardiogenic shock, effective antibiotic therapy, hemofiltration, and combined rhAPC-pentoxifylline therapy. Conclusions: The postiive outcome of this case indicates that rhAPC can be safely used in infants. A largescale study of the effectiveness of drotrecogin alpha in pediatric population is indicated.


    2177/2523

    Tytuł oryginału: EEG noise cancellation by a subspace method based on wavelet decomposition.
    Autorzy: Olkkonen Hannu, Pesola Peitsa, Olkkonen Juuso T., Valjakka Antti, Tuomisto Leena
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.MT199-MT204, il., bibliogr. 15 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Noise reduction techniques play an essential role in EEG signal processing applications. A variety of methods are currently in use, including those based on linear filtering and adaptive nooise cancellation, as well as subspace-based methods using singular value decomposition (SVD). SVD offers a robust method to decompose the data matrix nto signal and noise subspaes. However, the SVD algorithm is characterized by high computational complexity, which restricts its use in real time EEG signal analysis. Material/Methods: In this work we applied a wavelet transform to decompose the EEG signal into parallel subsignals. Noise was cancelled using the SVD-based method for each subsignal, and the noiseless EEG was reconstructed by using an inverse wavelet transform. EEGs were recorded in freely behaving rats from two different sites of the brain: 1) the hilar region of the dentate gyrus of the hippocampus, 2) the frontal cortex, with the electrode tip located in the vicinity of the epipial neocortical surface. Results: Our noise suppression method had hte most obvious effect on the EEG frequency spectrum, where random noise was considerably diminished. In the time domain, the reconstructed waveform closely resembled the original EEG signal, but it could clearly be seen that most of the transient spikes had been removed. Conclusions: THe present method offers remarkable computational savings and is especially well adapted for the analysis of highly dynamic EEGs.


    2178/2523

    Tytuł oryginału: Application of high resolution 31P NMR spectroscopy to the characterization of the phospholipid composition of tissues and body fluids - a methodological review.
    Autorzy: Schiller Jrgen, Arnold Klaus
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.MT205-MT222, il., tab., bibliogr. 91 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Background: The detailed analysis of lipids, especially phospholipids, has become progressively important, since these molecules represent intercellular messenger molecules and are involved in a number of diseases. Therefore, the analysis of the lipid pattern of blood, for example, may also be useful as a diagnostic tool. Unfortunately, suitable methods of p hospholipid analysis are often time-consuming and tedious, since most of them include a variety of separation and derivatization steps. methods allowing lipid analysis in a single step would be highly useful. The aim of this review is to show that high resolution 31P NMR spectroscopy is a convenient and precise analytical tool for the phospholipid analysis of extracts from biological samples (tissues and body fluids). The first part of this review discusses the physiological relevance of individual kinds of phospholipids and related, established analytical techniques for their investigation. THe second part contains an overview on the requireemnts for 31P NMR to improve spectral resolution and sensitivity, its cpabilities and its limitations. In the third part, we discuss the application of 31P NMR to the most important phospholipid classes, as well as different tissue and body fluid extracts. The article concludes with a brief look at future developments and potential applicaitons of the technique.


    2179/2523

    Tytuł oryginału: Confidentiality and the physician-patient relationship - ethical reflections froma a surgical waiting room.
    Autorzy: Clark Peter
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.SR31-SR34, bibliogr. 7 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The physician-patient relationship is the primary focus of ethics in medicine. It is both a personal and a professional relationship that is founded on trust, confidence, dignitiy and mutual respect. Trust is the bridge to the physician-patient relationship, and the burden is on the physician not only to expect the patient's trust but also to build a solid foundatin upon which the patient can place his or her trust. Great strides have been made by physicians in refining the physician-patient relatinship especially in understanding and respecting the patients' right of self-determination regarding medical decision-making and protecting their rights of privacy and confidentiality. However, further refinements are needed on both sides regarding this relationship. Breaches of confidentiality are cocurrig in places like surgical waiting rooms and as a result, the physician-patient relationship is being damaged. This article identifies some legitimate concerns and offers some concrete solutions so that the physician-patient relationship can be further refined and the virtues and rights that support it can be reinforced.


    2180/2523

    Tytuł oryginału: Amniotic fluid cells and human stem cells research - a new connection.
    Autorzy: Prusa Andrea-Romana, Hengstschl„ger Markus
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.RA253-RA257, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Currently it is the hope of both patients and ivnestigators that human progenitor cells and stem cells can be widely used to replace dysfunctional cells within a tissue. It is speculated that such cells may prove to have the potential to treat or cure a myriad of diseas, including Parkinson's and Alzheimer's diseases, heart disease, diabetes, stroke, spinal cord injuries, and burns. A major goal in this area of research is to identify potential new sources for the isolation of progenitor cells or stem cells, without raising the ethical issues involved in embryonic stem cell research. Despite the widespread and well-established use of amniotic fluid cells in routine prenatal genetic testing, current knowledge about the origin and properties of these cells is limited. A wide variety of different origins has been suggested for the mixture for the mixture of cells within amniotic fluid. Recent observations on cell cultures from amniotic fluid and on amniotic epitheilal cells provide evidence that they may represent new sources for the isolation of cells with the potency to differentiate into different cell types. Are these cells suitable for use as primary cell systems for basic research? Do these cells provide a new source for research on stem cell biology/ Can amniotic fluid cells be used to develop new approaches in tissue engineering? In this article the authors review the current state of knowledge aobut these cells, focusing on these questions.


    2181/2523

    Tytuł oryginału: Understanding the biology of oral cancer.
    Autorzy: Das Bibhu R., Nagpal Jatin K.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.RA258-RA267, tab., bibliogr. 115 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The present review is an attempt to summarize the important advances made during the last decade inthe molecular approach to oral cancer and its application for early, sensitive diagnosis, effective treatment, and improved prognosis. Cancer of the oral cavity is more prevalent in developing countries, where many people are addicted to tobacco chewing and maintain poor oral hygiene. Despite extensive research on the biological and molecular aspects of oral SCC, the problems of local-regional recurrence and distant metastasis still persist. Among the more pressing problems in clincial management is the lack of early detection, due to the absence of a potential diagnostic marker. Oncologists are now more aware of the challenges associated with the treatmetn of cancer of the oral cavity, and survival percentages are improving signfiicantly. More trials are need inthe area of improved surgical procedures, variations in dosages of radiotherapy, and the use of various combinations of chemotherapeutic agents with minimal side effects. Moreover, progress in the elucidation of the molecular genetic changes that lead to the development of these tumors should soon bring novel diagnostic and therapeutic procedures into clinical practice. The case of ONYX-015 is one example of success, which has shown the great potential in Phase-I and II clinical trials. Finally, the legislator should also impose some restrictions and bans on the easy availability of various forms of tobacco.


    2182/2523

    Tytuł oryginału: Oxytocin antagonists for tocolysis in preterm labour - a systematic review.
    Autorzy: Coomarasamy Aravinthan, Knox Ellen M., Gee Harry, Khan Khalid S.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.RA268-RA273, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Background: Oxytocin antagonists have been shown to inhibit uterine contractions and delay preterm delivery. Our objective was to examine the clinical effectiveness and safety of oxytocin antagonists for tocolysis in preterm labour. Material/Methods: We searched MEDLINE, EMBASE, the Cochrane Controlled Trials Register and Science Citation Idnex using the following Medical Subject Headings and textwords: oxytocin (antagonists and inhibitors), atosiban, antocin, oxytocin antagonists, oxytocin receptor antagonists and oxytocin inhibitors. All randomised controlled trials that compared effectiveness and safety of atosiban with a placebo or another tocolytic in women with threatened or actual preterm labour were included. The primary outcome measure was the proportion of women undelivered by 48 hours from the commencement of treatment. Resutls: Six articles met the inclusion criteria - two compared atosiban to placebo and four atosiban to a beta-agonsit. Meta-analysis showed a signficant increase in the proportion of women undelivered by 48 hours in women receiving atosiban compared to placebo (RR 1.13, 95 p.c. CI 1.02, 1.26). When compared with beta-agonists, atosiban increased the proprtion of women undelivered by 48 hours, but this trend did not reach statistical significance (RR 1.07, 95 p.c. CI 0.98, 1.17). Side effect profile was substantially better for atosiban compared to beta-agonists. Conclusions: Oxytocin antagonists appear to be effective and safe for tocolysis in preterm labour.


    2183/2523

    Tytuł oryginału: Nitric oxide as a unique signaling molecule in the vascular system: a historical overview.
    Autorzy: Ignarro L. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.503-514, bibliogr. 69 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In retrospect, basic research in the fields of NO and cyclic GMP during thev past two decades appears to have followed a logical course beginning with the findings that NO and cyclic GMP are vascular smooth muscle relaxants, that nitroglycerin relaxes smooth muscle by metabolism to NO, progressing to the discovery that mammalian cells synthesize NO, and finally the revelation that NO is a neurotransmitter mediating vasodilation in specialized vascular beds. A great deal of basic and clinical research on the physiological and pathophysiological roles of NO in cardiovascular function has been conducted since the discovery that EDRF is NO. The new knowledge on NO should enable investigators in this field to develop novel and more effective therapeutic strategies for the prevention, diagnosis and treatment of numerous cardiovascular disorders. Since NO elicits a protective and beneficial action in many disease states, novel NO donor drugs for clinical use should prove to be very effective drugs for the treatment of essential hypertension, stroke, coronary artery disease, vascular complications of diabetes , impotency and other disorders involving the vascular system.


    2184/2523

    Tytuł oryginału: Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.
    Autorzy: Channon K. M., Guzik T. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.515-524, bibliogr. 62 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Common vascular disease states including diabetes, hypertension and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Loss of the vasculoprotective effects of NO contributes to disease progression, but the mechanisms underlying endothelial dysfunction remain unclear. Increated superoxide production in animal models of vascular diseaase contributes to reduced NO bioavailability, endothelial dysfunction and oxidative stress. In human blood vessels, the NAD(P)H oxidase system is the principal source of superoxide, and is functionally related to clinical risk factors and systemic endothelial dysfunction. Furthermore, the C242T polymorphism in the NAD(P)H oxidase p22phox subunit is associated with significantly reduced superoxide production in patients carrying the 242T allele, suggesting a role for genetic variation in modulating vascular superoxide production. In vessels from patients with diabetes mellitus, endothelial dysfunction, NAD(P)H oxidase activity and protein subunits are significantly increased compared with matched non-diabetic vessels. Furthermore, the vascular endothelium in diabetic vessels is a net source of superoxide rather than NO production, due to dysfunction of endothelial NO synthase (eNOS). This deficit is dependent on the eNOS cofactor, tetrahydrobiopterin, and is in part mediated by protein kinase C signalling. These studies suggest an important role for both the NAD(P)H oxidases and endothelial NOS in the increased vascular superoxide production and endothelial dysfunction in human vascular disease states.


    2185/2523

    Tytuł oryginału: The eicosanoid factor: a determinant of individuality of nephron segments.
    Autorzy: McGiff J. C., Ferreri N. R., Carroll M. A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.525-532, il., bibliogr. 25 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Background: Nephron function is segmented each segment has characteristic transport mechanisms and individual eicosanoid profiles. The transport function of the medullary thick ascending limb of Henle's loop (mTAL) estabilishes the osmolar gradient upon which extra cellular fluid volume (ECFV) conservation depends. The overriding importance of the mTAL to regulation of ECFV is evident in the diuretic-natriuretic potency of furosemide-like agents which target the mTAL. Results: The mTAL has been shown to be heavily invested with cytochrome P450 monooxygenases (CYP), chiefly omega/omega-1 hydroxylase activity, that generate 19- and 20-hydroxyeicosatetraenoic acid (HETEs). However, displacement of omega hydroxylase by an inducible cyclooxygenase mechanism (COX-2) can be effected by several interventions: long-term infusion of angiotensin II (ANG II), adrenalectomy and elevated extracellular Ca2+ concentrations. This switching mechanism (CYP COX-2) has been shown to be dependent on activation of tumor necrosis factor ŕ (TNFŕ) by ANG II. It represents a long-term adaptative mechanism of the mTAL with production of PGE2 whereas in the short-term, ANG II increases 20-HETE synthesis by the mTAL. The effect of Ca2+ on mTAL eicosanoid-related mechanisms provides an explanation for the natriuretic response to hypercalcemia and diminished ability to concentrate urine. Conclusion: The expression of COX-2 in the TAL has been linked to activation of the renin-angiotensin system, glucocorticoid deficiency and hypercalcemia, all of which operate through a mechanism in which production of TNFa by the TAL is pivotal.


    2186/2523

    Tytuł oryginału: Angiotensin-(1-7): an active member of the renin-angiotensin system.
    Autorzy: Kucharewicz I., Pawlak R., Matys T[omasz], Chabielska E[wa], Buczko W[łodzimierz]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.533-540, bibliogr. 60 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Angiotensin-(1-7) [Ang-(1-7)] is an active member of renin-angiotensin system (RAS). It counterbalances vasoconstriction, mitogenic, arrhythmogenic and prothrombotic actions of Ang II. Inducing natiuresis and diuresis opposes also the water and sodium retention produced by Ang II. Till now the specific receptor side for Ang-(1-7) has been not cloned, but the current data strongly suggest that an interaction (cross-talk) between angiotensin receptors may play a role in the effects of Ang-(1-7).


    2187/2523

    Tytuł oryginału: The annexin-1 knockout mouse: what it tells us about the inflammatory response.
    Autorzy: Roviezzo F., Getting S. J., Paul-Clark M. J., Yona S., Gavins F. N. E., Perretti M., Hannon R., Croxtall J. D., Buckingham J. C., Flower R. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.541-553, il., tab., bibliogr. 85 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postilated to be a mediator of glucocorticoids action in inflammation and in the control of anterior pituitary hormone release. Immuno-neutralisation or antisense strtegies support this hypothesis as they can reverse the effect of glucocorticoids in several systems. We recently generated a line of mice lacking the Anx-1 gene noting that some tissues taken from such animals exhibited an increased expression of several proteins including COX-2 and cPLA2. In models of experimental inflammation, Anx-1 mice exhibit an exaggerated response and a partial or complete resistance to the anti-inflammatory effects leukocyte adhesion molecule expression, an increased spontaneous migratory behaviour of PMN in Anx-1 mice and a resistance in Anx-1 macrophages to glucocorticoid inhibition of superoxide generation. This paper reviews these and other data in the light of the development of the 'second messenger' hypothesis of glucocorticoid action.


    2188/2523

    Tytuł oryginału: A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock.
    Autorzy: McDonald M. C., Izumi M., Cuzzocrea S., Thiemermann C.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.555-569, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: An enhanced formation of nitric oxide (NO) by the inducible NO synthase (iNOS) may contribute to pathophysiology of hemorrhagic shock. This study investigates the effect of a novel, potent and selective inhibitor of iNOS activity (GW274150) on the circulatory failure and the organ injury and dysfunction associated with hemorrhagic shock in the anesthetised rat. Hemorrhage (sufficient to lower mean arterial blood pressure to 45 mmHg for 90 min) and subsequent resuscitation with shed blood resulted (within 4h after resuscitation) in a delayed fall in blood pressure, renal and liver injury and dysfunction as well as the pancreatic injury. Pre-treatment of rats with GW274150 (5 mg/kg at 30 min prior to the onset of hemorrhage) attenuated the renal dysfunction as well as the liver and pancreatic injury caused by hemorrhage and resuscitation. Interestingly, GW274150 did not reduc the delayed fall in blood pressure associated with hemorrhagic shock. We propose that an enhanced formation of NO from iNOS contributes to the organ injury and dysfunction in hemoohagic shock, and that highly selective inhibitors of iNOS activity, such as GW274150, may represent a novel therapeutic approach for the therapy of hemorrhagic shock.


    2189/2523

    Tytuł oryginału: Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis.
    Autorzy: Kalinowski L., Dobrucki I. T., Maliński T.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.585-595, il., bibliogr. 32 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Endothelium dysfunction, which is often defined as a decrease in NO bioavailability, is one of the earliest manifestations of endothelium-impaired finction disorders, including atherosclerosis. Although improvement in NO bioavailability has been attributed to the lowering of serum cholesterol levels, recent studies suggest that HMG-CoA reductase inhibitors, statins, may have direct effects on NO bioavailability by little known mechanisms that are independent of serum cholesterol levels. The long-term effect of cerivastatin on NO release from endothelial cells was determined by using highly sensitive electrochemical microsensors and was correlated with endothelial NO synthase (eNOS) levels. To explore whether changes in isoprenoid synthesis affect NO bioavailability and eNOS expression, human endothelial cells were treated with cerivastatin, L-mevalonate (MVA; 1.5 mmol/L), geranylgeranylpyrophosphate (GGPP; 1mg/mL) and farnesylpyrophosphate (FPP; 1mg/mL). Cerivastatin increased spontaneous (by 53 p.c. ń 6) and an eNOS-stimulated NO release (by 41 ń 6 p.c. for calcium ionophore and by 47 ń 5 p.c. acetylcholine) as well as eNOS expression (by 118 ń 6 p.c.) in the same concentration-range. Cerivastatin-dependent increase in both NO release and eNOS expression was revealed after ~4h of exposure reaching the maximum after ~10 h. Co treatment with MVA or GGPP, but not FPP or LDL, reversed the effects of cerivastatin. These findings indicate that the long-term effect of cerivastatin resulting in enhanced ...


    2190/2523

    Tytuł oryginału: XI Polish Society for Immunology Congresss, Olsztyn, Poland, 18-21 September 2002 - abstracts.
    Źródło: Centr. Eur. J. Immunol. 2002: 27 suppl. 1: XI Polish Society for Immunology Congress s.1-154, il., tab. - 11 Kongres Polskiego Towarzystwa Immunologicznego Olsztyn 18-21.09. 2002
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • streszczenie
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Temat korporatywny:
  • Polskie Towarzystwo Immunologiczne


    2191/2523

    Tytuł oryginału: Osteoprotegerin and sRANKL serum levels in multiple myeloma patients.
    Autorzy: Centkowski Piotr, Kraj Maria, Kruk Barbara, Sokołowska Urszula
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.129-135, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Beckground: Receptor activator of NF-kappaB (RANK) is a TNF receptor superfamily member expressed on the surface of osteoclasts and their precursors that mediates their differentation, survival, and activation upon interaction with its ligand, RANKL, expressed by osteoblasts, stromal cells and multiple myeloma (MM) plasma cells, RANKL is produced as a membrane bound protein and cleaved into a soluble form by a metalloprotease. The primary secreted form is produced by activated T-lymphocytes. Osteoprotegerin (OPG) is a secreted TNFR, it acts as a decoy receptor for RANKL and inhibitor of RANK-RANKL interaction. Recent studies suggest that MM triggers osteoclastogenesis by disrupting the balance between RANKL and its natural inhibitor, OPG. Therefore in this study we analyzed the concentrations of serum OPG and sRANKL in MM patients at diagnosis. Material and methods: Determinations of serum OPG and sRANKL concentrations were performed in 25 healthy subjects and 44 MM patients (6 at stage I, 2 - II, 29 - IIIA, 7 - IIIB acc. to DS.m 33 had lytic lesions at skeletal X-ray survey; monoclonal protein IgG was in 33 patients, IgA - 6, Bence Jones - nonsecretory - 1) bymeans of ELISA method using Osteoprotegerin Elisa and sRANKL ELISA kits (Biomedica, GmbH, Vienne, Austria). Results: In the whole group of MM patients, OPG concetration in particular patients ranged from 42 to 346 pg/ml with a mean concentration of 111 ń 69, median 88 pg/ml while in healthy age - and sexmatched controls OPG levels ranged from 49 to 130 pg/ml, mean 77 ń 22, median 74 pg/ml (p = 0,0208)...


    2192/2523

    Tytuł oryginału: Anti-elastase antibodies and neutrophil elastase in children with respiratory tract inflammation.
    Autorzy: Polańska Bożena, Jankowski Adam, Kaźmierowska-Niemczuk Maria, Leszczyk-Kapusta Iwona
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.136-141, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: The neutrophil elastase is implicated in tissue damage occuring in the course of several chronic inflammatory conditions. The aim of the study was to evaluate the presence of antibodies to neutrophil elastase (aE) in serum and plasma levels of neutrophil elastase complexed eith ŕ1-proteinase inhibitor (E-ŕ1PI). Subjects were 1 - 16 years ild children suffering from recurrent upper respiratory tract infection (A, n=35), mild atopic asthma (Ba, n=23), recurrent brobchitis without obstruction (Bb, n=27) and 13 healthy controls (C). Parameters were measured (ELISA technique) in the acute phase of the disease (I), and in the stage without signs of disease (II). There was no significant difference in serum values of aE in children from A, Ba and Bb group compared to controls. But in individual cases levels of antibodies were positive. We observed significant elevation of E-ŕ1PI levels in plasma of children from A and Ba groups. We found significant negative correlation between E-ŕ1 PI and aE in examination I and II in children from group A, and in examination II in children from Bb group. Our data suggest that aE may be present in serum of children with respiratory tract infections and E-ŕ1 PI may be an useful indicator of neutrophils activation.


    2193/2523

    Tytuł oryginału: The effect of Centella asiatica, Echinacea purpurea and Melaleuca alternifolia on cellular immunity in mice.
    Autorzy: Skopińska-Różewska Ewa, Furmanowa Mirosława, Guzewska Joanna, Sokolnicka Irena, Sommer Ewa, Bany Janusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.142-148, il., tab., bibliogr. 54 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • płeć męska
  • płeć żeńska
  • myszy

    Streszczenie angielskie: Two herbal extracts, Centella asiatica, Echinacea purpurea, and oil of Melaleuca alternifolia, which have been used as folk medicine in Asia, America and Australia respectively, were administered to Balb/c mice and evaluated for their ex vivo ability to influence in vitro proliferative, and in vivo local groft-versus-host activity of splenic lymphocytes (cutaneous angiogenesis test, LIA). Significant stimulatory effect of Centella on lymphocyte proliferative response and inhibitory on splenocytes angiogenic activity was observed. Echinacea enhanced lymphocyte proliferation in the presence of low and intermediate concentration of mitogen only, G-V-H splenocytes activity was stimulated by Echinacea. Inhalations of mice with Melaleuca alternifolia (tea tree) oil resulted in suppression of splenocytes proliferative activity, except intermediate concentration of mitogen after shorter exposition to oil, where stimulation was observed. Tea tree oil enhanced angiogenic activity of splenocytes.


    2194/2523

    Tytuł oryginału: The role of histamine in inflammation - current viewpoint.
    Autorzy: Brzezińska-Błaszczyk Ewa
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.149-159, tab., bibliogr. 153 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: It is well documented that apart from mast cells and basophils there are other cells that can produce and release histamine. Moreover, histamine exerts its biological actions through four types of histamine receptors. Nowadays histamine is recognized for its multiple biological activities regulating both psychological and pathological processes as one of humoral factors. What is more, histamine is indisputably one of the essential factors regulating inflammatory reaction not only in early phase but also in the course of chronic phase of inflammation.


    2195/2523

    Tytuł oryginału: Neutrophil elastase as an inflammatory mediator.
    Autorzy: Polańska Bożena
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.160-168, il., tab., bibliogr. 77 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Neutrophilis are the first cells recruited to the site of an infection. The influx of neutrophils within the sites of inflammation plays the important role in the normal human defense, but also may contribute to the pathogenesis of various disorders. They are capable of causing tissue destruction and cell death. Neutrophilic inflammation is observed in patients with ŕ1-proteinase inhibitor deficiency, bronchitis, emphysema, ARDS, COPD, re-perfusion injury, cystic fibrosis, acute severe asthma, cigarette smoking. The numerous data suggest that neutrophil elastase (NE) is an important mediator of the acute and chronic inflammatory response. NE perpetuates the cycle of inflammation by promoting the generation of chemoattractants, particulary interleukin-8 and leukotriene B4, which recruit more neutrophils into the tissue. The stimulation status of neutrophils in inflamed tissue can be estimated by measuring the concentration of neutrophil elastase in complex with ŕ1-proteinase inhibitor (NE-ŕ1PI). The examination of plasma levels of NE-ŕ1PI can be used as a novel and sensitive indicator of the acute and chronic response and neutrophilis activation in different diseases. The dynamic changes of the concentration of NE-ŕ1PI may be of diagnostic, prognostic and therapeutic importance. It seems that the determination of free NE or NE-ŕ1PI complex in body fluid can be accepted to the routine use in diagnostic of inflammatory state of organisms. New treatment starategies for neutrophil inflammation are being developed. Several studies demonstrate that antiprotease therapy may be effective to inhibit NE and reduce the inflammation state.


    2196/2523

    Tytuł oryginału: Intravenous immunoglobulin in clinical practice.
    Autorzy: Bernatowska Ewa, Hooper John, Jastrzębska-Piotrowska Janina
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.169-175, tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Although initially used for immunodeficiency disorders, intravenous immunoglobulin (IVIG) has been utilized as a prophylactic and therapeutic agent in a variety of other clinical conditions. The rapid growth in IVIG use is the result of improvements in IVIG preparations and reports of benefits in a number of unexpected clinical applications. IVIG has been used in such diverse diseases as primary immunodeficiencies, periatric AIDS, low birth weight infants, bone marrow transplantation, chronic lymphocytic leukemia, idiopathic thrombocytopenic purpura. Kawasaki syndrome and demylinating polyneuropathies. However, omportant questions about doses and mechanisms still remain. This review describes clinical applications of IVIG that are clearly indicated and approved by national regulatory agencies. Other clinical applications supported by convincing clinical trials are also described.


    2197/2523

    Tytuł oryginału: The role of NF-kappa B transcription factor in inflammatory processes.
    Autorzy: Żeromski Jan
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.176-180, tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Among various cell transcription factors, nuclear factor-kappa B (NF-kB) probably belongs to the important ones. Its universal nature, ubiquitous expression in almost every cell and participation in various biological phenomena such inflammation, cell death, or cancer, resulted in rising great interest on NF-kB within world scientific community. Its role in inflammatory processes is evident in almost each condition. In the majority of cases, however, the activation of the factor in question leads to intensification of inflammatory processes. Nevertheless, NF-kB proteins play a pivotal role in defense of the body against various pathogens. There is evidence that many anti-inflammatory drugs, such as glucocorticoids or aspirin act by the inhibition of particular components of the factor. Better understanding of mechanisms of action of NF-kB may yield specific tools able to switch off its proteins selectively active in various pathological conditions.


    2198/2523

    Tytuł oryginału: The influence of low molecular weight heparin on the intravascular activation of the coagulation system in patients with acute leukemia during induction chemotherapy - report of prospective randomized study.
    Autorzy: Chojnowski Krzysztof, Treliński Jacek, Wawrzyniak Ewa, Robak Tadeusz
    Źródło: Leuk. Lymphoma 2002: 43 (5) s.1021-1028, il., tab., bibliogr. 19 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Intravascular activation of the coagulation system can already be observed in the majority of patients with acute leukemia (AL) at hte time of diagnosis. This activation can be further enhanced by chemotherapy. The study comprised of 46 patients with AL, randomly divided into two groups. Twenty-three patients received prophylactic doses of nadroparin (Fraxiparine). Thrombin-antithrombin complexes (TAT), prothrombin fragment (F1 + 2), D-dimer (DD), plasmin-antiplasmin complexes (PAP) and antithrombin III (AT III) activity were determined in all patients. The tests were performed before treatment, and on the 3rd and 8th days of chemotherapy. The TAT, F1 + 2, DD and PAP concentrations were found to be elevated in 83 p.c. of patients already at the time of diagnosis. No significant difference between either groups test results was noted when either tested before treatment or on the third day of therapy. DIC (disseminated intravascular coagulation) syndrome appeared in two patients receiving heparin prophylaxis and in three patients to whom this treatment was not administered. The concentrations of activation markers on the eighth day of chemotherapy were lower than at the beginning of treatment in most of the patients receiving nadroparin. At this time there were no laboratory signs of DIC in any of the patients receiving heparin prophylaxis. In conclusion: although the application of prophylactic doses of nadroparin does not prevent DIC syndrome during first days of chemotherapy, it may limit the intravascular activation of the coagulation system during later chemotherapy.


    2199/2523

    Tytuł oryginału: Aggressive primary plasma cell leukemia with skin manifestations, trisomy 8 and molecular oligoclonal features.
    Autorzy: Robak Tadeusz, Urbańska-Ryś Halina, Bartkowiak Jacek, Strzelecka Bogusława, Biernat Wojciech, Kordek Radzisław
    Źródło: Leuk. Lymphoma 2002: 43 (5) s.1067-1073, il., bibliogr. 40 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Plasma cell leukemia (PCL) is a very rare variant of multiple myeloma (MM) occuring in about 2 p.c. of newly diagnosed patients. Plasma cell leukemia may develop during the course of MM (secondary PCL) or it can occur without any prior sign of MM (primary PCL). We report a case of aggressive primary PCL with unusual clinical, cytogenetic and molecular features. A 36-year-old male patient was first seen because of fever and bone pain. On the skin of his chest, back, abdomen, and palpebras, there were nodular infiltrations resembling urticaria. White blood cell count was 10.8x10**9/1 with 41 p.c. plasmacytes. Bone marrow aspiration was hypercellular, 93.5 p.c. of cells were atypical plasmacytes and plasmablasts. The cytogenetic analysis of G-banded chromosomes in bone marrow cells yielded the trisomy 8. The skin biopsy specimen showed intensive infiltrates of uninucleated blastic cells similar to those found in the bone marrow. Immunophenotyping of bone marrow and skin neoplastic cells showed CD45+, CD45R0+, CD68+, CD38+ and cytoplasmic kappa light chain+. The neoplasic cells stained negatively for lambda light chain, CD3, CD20, CD30, EMA, CD15, CD34, CD56 and factor VIII. The pattern of IgL genes rearrangement in the bone marrow aspirate, peripheral blood mononuclear cells, and skin specimens was examined by PCR analysis. All studied specimens showed three different Igkappa gene configurations suggesting that the neoplastic cells originated as a result of oligoclonal lymphoproliferation process. The patient received two courses of VAD (vincristine, doxorubicin, dexamethasone)...


    2200/2523

    Tytuł oryginału: Acute lymphoblastic leukemia in adult first manifested as severe aplastic anemia - role of molecular analysis in correct diagnosis.
    Autorzy: Robak Tadeusz, Bartkowiak Jacek, Urbańska-Ryś Halina, Szmigielska-Kapłon Anna, Strzelecka Bogusława, Chojnowski Krzysztof
    Źródło: Leuk. Lymphoma 2002: 43 (5) s.1147-1152, il., bibliogr. 40 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Aplastic anemia (AA) may sometimes precede the diagnosis of acute lymphoblastic leukemia (ALL) in children. Such presentation of ALL is externally rare in adults and until now only few such cases have been reported. We present a 40-year-old male with ALL common type, which developed 14 months after the diagnosis of severe AA, successfully treated with corticosteroids. ALL was treated with standard induction chemotherapy but remission has not been achieved. The patient died 6 weeks after the diagnosis of ALL because of central nervous system bleeding. The pattern of IgH gene rearrangement analyzed with PCR method in bone marrow from the period of AA diagnosis and in peripheral blood mononuclear cells from ALL diagnosis showed two different monoclonal IgH configurations as the results of biallelic monoclonal rearrangement of IgH genes. The observed bands in both specimens were identical and indicated that leukemic cells originated from B-cell progenitor were also present in the bone marrow when AA was diagnosed. We suggest that molecular analysis of monoclonality in patients with AA may be important for proper selection of the rare cases of ALL first presenting as marrow aplasia.


    2201/2523

    Tytuł oryginału: Lymphoplasmacytic lymphoma with monoclonal gammopathy-related pseudo-gaucher cell infiltration in bone marrow and spleen-diagnostic and therapeutic dilemmas.
    Autorzy: Robak Tadeusz, Urbańska-Ryś Halina, Jerzmanowski Piotr, Bartkowiak Jacek, Liberski Paweł, Kordek Radzisław
    Źródło: Leuk. Lymphoma 2002: 43 (12) s.2343-2350, il., bibliogr. 36 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Gaucher-like cells have occasionally been described in various haematological malignancies including Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma (MM) and chronic myelogenous leukemia (CML). A special type of this phenomenon is crystal-storing histocytosis or the so-called pseudo-pseudo Gaucher cells (PPGC) in which crystalline protein storage in macrophages is induced by paraproteinemia. Here we describe a 54-year-old man with an initial suspicion of Gaucher disease and monoclonal IgA gammopathy in whom a correct diagnosis of lymphoplasmacytic lymphoma (LPL) with massive infiltration of bone marrow and spleen by PPGC was confirmed by immunological, ultrastructural and molecular characterisation. The activity of leukocyte beta-glucocerebrosidase was only slightly elevated (7.3 nmol/mg protein/1h) which ruled out the diagnosis of classic Gaucher's disease. The patient received two courses of CHOP without improvement and anti-CD20 monoclonal antibody (rituximab) with only temporary stabilisation. Subsequently, he underwent splenectomy because of prolonged severe pancytopenia and a suspicion of hypersplenism. After splenectomy significant haematological improvement was observed. Following anti-CD20 therapy, changes in immunoprofile and morphology of tumour cells were evident. Before treatment the population of LPL was more divergent, with expression of LCA, CD20, CD38 and CD138. However, after the treatment, there were more mature plasma cells which no longer expressed CD20 antigen-this picture was more consistent with the diagnosis of plasma cell myeloma...


    2202/2523

    Tytuł oryginału: Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras.
    Autorzy: Kałas Wojciech, Kisielow Paweł, Strządała Leon
    Źródło: Leuk. Lymphoma 2002: 43 (7) s.1469-1474, il., bibliogr. 27 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Published results implicate PI3 kinase as a target of oncogenic Ras activity leading to the suppression of Fas but whether other Ras targets (e.g. Raf-1) are also involved is inclear. Here we report that thymic lymphomas overexpressing Ras and Raf-1 exhibit low expression of Fas. We show that expression of Fas in these lymphomas can be increased not only in the presence of a specific inhibitor (LY294002) of PI3 kinase, but also in the presence of specific inhibitor (PD98059) of MEK, downstream target of Raf-1. Both treatments result in accumulation of ERK in cytosol of lymphoma cells suggesting cross-talk between these two pathways regulating Fas expression. Treatment with PD98059 also results in apoptosis of the lymphoma cells but not of normal thymocytes expressing low Raf-1 levels. These observations provide evidence for involvement of Raf-1/MEK/ERK pathway in Ras-mediated inhibition of Fas expression and in selective promotion of survival of lymphoma cells.


    2203/2523

    Tytuł oryginału: Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis.
    Autorzy: Borowicz Kinga K., Świąder Mariusz, Łuszczki Jarogniew, Czuczwar Stanisław J.
    Źródło: Epilepsia 2002: 43 (9) s.956-963, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 304,834

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Purpose: The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsion in mice. Methods: Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the end point). Adverse effects were evaluated with the chimney test (motor performance) and passive-avoidance task (long-term memory). Plasma levels of AEDs were measured by immunofluorescence or high-pressure liquid chromatography. Results: GBP (ó50 mg/kg) remained ineffective on the electroconvulsive threshold. According to the isobolographic analysis, GBP appears to act synergistically with carbamazepine, valproate, phenytion, phenobarbital (PB), lamotrigine (LTG), and LY 300164. The pharmacokinetic events may be responsible for the interactions of GBP/PB and GBP/LTG, because only PB and LTG significantly elevated the plasma concentration of this AED. Conversely, GBP did not affect the plasma levels of other AEDs used in this study. No adverse effects, were induced by combinations of GBP with these AEDs. Conclusions: The isobolographic analysis revealed that combinations of GBP with other AEDs generally results in entin-Antiepileptic drugs-Electroshock maximal-Drug interactions-Seizures-Isobolography.


    2204/2523

    Tytuł oryginału: Adaptation of Zweig's model of cochlea with wave interaction correction to experimental data pf DPOAE phase.
    Autorzy: Siedlecki Tomasz
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.1-14, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The influence of a nonlinear two-wave interaction on the phase of the distortion product otoacoustic emission (DPOAE) has been investigated. Assuming the cochlear amplifier model of Zweig, we have calculated the DPOAE phase. The discrepancy between the numerical results based on the model and the existing data indicates a need for including the two-wave interactions in the cochlear amplifies theory. With the nonlinear correction to the wave numbers of the waves, good agreement with experimental data may be obtained. However, the DPOAE phase-nonlinearity could also be obtained if the direction of wave front were dependent on the intensity.


    2205/2523

    Tytuł oryginału: Computer simulations of coronary By-pass procedures based on an electric analogue model of the left coronary artery.
    Autorzy: Kostka Paweł, Nawrat Zbigniew, Małota Zbigniew
    Źródło: Pol. J. Med. Phys. Engin. 2002: 8 (1) s.23-28, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,499

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Estimating the flow curve in coronary arteries is of great importance both from point of view of diagnosis, modeling and simulation. The aim of this work is to create a model of the coronary artery tree, simulate the stenosis areas in a particular coronary vessel and study the influence of different stenosis levels and coronary by-pass connections on the flow pattern. The model of the left coronary artery was created, based on an arteriogram developed by Sapoznikow [3] and Wang [4], where the vessel was divided into 14 segments described by geometrical and mechanical parameters. Each unit in the model is represented by an electrical analogue circuit, with R, L, C values obtained from coronary artery parameters based on the relationships resulting from Newtonian and continuity equations. The model-network of adequately connected blocks of transfer functions - corresponding to each left coronary artery segment was implemented in the Matlab-Simulink environment. A local stenosis was simulated by the change in geometrical and mechanical features of a particular segment causing a change in its transfer function. As a result of computer simulations performed on the model, the flow and pressure signals in a chosen aortic segment can be computed.


    2206/2523

    Tytuł oryginału: Novel N-{omega-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl}pyrid-2(1H)-ones with diversified 5-HT 1A receptor activity.
    Autorzy: Paluchowska Maria H., Bugno Ryszard, Charakchieva-Minol Sijka, Wesołowska Anna, Chojnacka-Wójcik Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.641-646, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • in vitro

    Streszczenie angielskie: Novel omega-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl derivatives 1-6 containing 4-, 5- and/or 6-arylsubstituted pyrid-2(1H)-one moiety were synthesized. All the new compounds were examined in vitro to assess their 5-HT 1A and 5-HT 2A receptor affinities. Compounds 3 and 4 with a 5- or a 6-phenylsubstituted pyridone ring demonstrated high 5-HT 1A receptor affinity (Ki=17 and 38 nM, respectively) and were tested in behavioral functional models. Derivative 3 can be regarded as a weak 5-HT 1A postsynaptic antagoninist, whereas 4 showed features of a weak partial agonist of 5-HT 1A receptors (an agonist of pre- and an antagonist of posstynaptic ones). Binding affinities and in vivo results were discussed in comparison with those for the previously described tetramethylene analogs. The obtained results showed that the shortening of the aliphatic chain to two methylene groups exposed the intrinsic activity of the ligand 4 and 5-HT 1A receptor sites.


    2207/2523

    Tytuł oryginału: Thioridazine-fluoxetine interaction at the level of the distribution process in vivo.
    Autorzy: Wójcikowski Jacek, Daniel Władysława A.
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.647-654, tab., bibliogr. 28 poz.
    Sygnatura GBL: 313,156

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The aimed of the present study was to investigate the effect of the distribution interaction between thioridazine and fluoxetine in vivo. Experiments were carried out on male Wistar rats. Animals received thioridazine and fluoxetine separately or jointly, at a dose of 10 mg/kg ip. Concentrations of thioridazine and its metabolites and fluoxetine in the plasma and tissues were measured at 1 h after administration of the drugs (HPLC). Effects of distribution interactions were estimated on the basis of the calculated tissue/plasma and lysosome-poor/lysosome-rich tissue concentration ratios, considering the heart and muscles as lysosome-poor tissues and the lungs, liver and kidneys as lysosome-rich ones. Fluoxetine diminished the tissue/plasma concentration ratio of thioridazine for the lungs, but elevated this ratio for the muscles and heart. On the other hand, thioridazine elevated the brain/plasma and heart/plasma concentration ratios of fluoxetine. Consequently, the thioridazine lysosome-poor/lysosome-rich tissue concentration ratios significantly increased in the presence of fluoxetine. At the same time, thioridazine raised (or showed such a tendency) the heart/lysosome-rich tissue concentration ratios of fluoxetine not changing significantly the muscles/lysosome-rich tissue concentration ratios of the antidepressant. The presented results provide evidence that the distribution interactions between thioridazine and fluoxetine observed in vitro occur also in vivo, leading to a shift of the drugs from organs rich in lysosomes to those poor in these organella, in particular....


    2208/2523

    Tytuł oryginału: TNF-ŕ in cerebral cortex and cerebellum is affected by amygdalar kindling but not by stimulation of cerebellum.
    Autorzy: Godlevsky Leonid S., Shandra Alexei A., Oleinik Andrei A., Vastyannov Rooslan S., Kostyushov Vladimir V., Timchishin Oleg L.
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.655-660, tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: One group of male Wistar rats was kindled by electrical stimulation (ES) of the amygdala, one group was sham operated, while other rats were stimulated in the paleocortex of the cerebellum. The kindled generalized clonic-tonic seizures were followed by a net increase of the tumor necrosis factor-ŕ (TNF-ŕ) content both in the cerebral cortex (from 34.7 ń 6.0 to 76.7 ń 6.9 pg/mg of wet brain tissue) and cerebellum (from 106.6 ń 17.7 to 193.8 ń 29.8 pg/mg of wet tissue) in comparison with the data from sham-operated animals. This effect was observed 24 h after the induction of the last kindled seizures. ES of the cerebellum (100 Hz) was not followed by any changes in TNF-ŕ content in the cortex and cerebellum. Morevover kindling was not followed by any changes in thiol/disulfide system, but ES of the paleocerebellum induced an increase in free thiol groups in the cortical tissue. It can be concluded that the increase in TNF0ŕ content in specific for the kindling process and that the antiepileptic effects of cerebellar ES might be realized via an intensification of antioxidative processes in the neural tissue.


    2209/2523

    Tytuł oryginału: Differential effect of 3-hydroxy-3-methyl-glutarylcoenzyme as reductase inhibitors on plasma paraoxonase 1 activity in the rat.
    Autorzy: Bełtowski Jerzy, Wójcicka Grażyna, Jamroz Anna
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.661-671, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Statins (3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors), apart from lowering plasma cholesterol, modulate other process involved in atherogenesis. The aim of this study was to investigate the effect of a natural statin, pravastatin, and of the synthetic one, fluvastatin, on plasma paraoxonase 1 (PON1), the antioxidant enzyme contained in plasma high-density lipoproteins. The adult male Wistar rats received other pravastatin (4 or 40 mg/kg/day) or fluvastatin (2 or 20 mg/kg/day) for 3 weeks. Then, plasma PON1 activity, lipid peroxidation products and total antioxidant capacity were assayed. Fluvastatin at a dose of 20 mg/kg/day decreased paraxon-hyrolyzing activity of PON1 by 23.6 p.c. and its phenyl acetate-hydrolyzing activity by 17.4 p.c. Lower dose of this drug as well as either dose of pravastatin had no effect of these activities. Fluvastatin at doses of 2 and 20 mg/kg/day decreased ç-decanolactone-hydrolyzing activity of plasma by 19.1 p.c. and 30.9 p.c, respectively. Statins had no effect on either total or HDL-cholesterol but markedly reduced plasma triglycerides. Fluvastatin had a more marked antioxidant activity, as evidenced by significant reduction of plasma concentration of malonyldialdehyde + hydroxydialkenals and lipid hydroperoxides, as well as by elevation of total plasma antioxidant capacity and plasma concentration of reduced sulfhydryl groups. These results suggest that fluvastatin but not pravastatin decreases plasma PON1 activity in normolipidemic rats, however, the former drug is more effective in reducing the level of oxidative stress.


    2210/2523

    Tytuł oryginału: Some drug effects on the activity of erythrocyte hexokinase and glucose 6-phosphate dehydrogenase enzymes in vitro and in vivo.
    Autorzy: Ciftci Mehmet, Senyayla Faruk, ™zdemir Hasan, Bykokuroglu Mehmet E.
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.673-679, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: Effects of theophyline, lidocaine, cyclophosphamide, hyoscine N-butyl bromide, tranexamid acid and cytarabine on hexokinase (HK) from human erythrocytes have been investigated in vitro. In addition, in vivo effects of theophylline and lidocaine were investigated in rats. HK was purified from human red blood cells by DEAE-Sephadex A50 ion exchange chromatography. HK activity was measured spectrophotometrically at 25řC in a system coupled with glucose 6-phosphate dehydrogenase, according to Beutler's method at 340 nm. Cyclophosphamide, hyoscine N-butyl bromide, tranexamic acid and cytarabine had no effects on human erythrocyte HK activity in in vitro conditions. On the other hand, human erythrocyte HK was inhibited by theophyline, but activated by lidocaine. IC 50 value for theophylline was 0.013 M. In the case of in vivo studies, 6 mg kg-1 of theophylline inhibited the rat HK activity by 43 p.c. at the first 1.5 h (p 0.001). A dose of 5 mg kg-1 of lidocaine activated the rat HK activity by 41 p.c. (p 0.001), 22 p.c. (p 0.001), and 11 p.c. (p 0.05), at 1.5, 3 and 6 h respectively.


    2211/2523

    Tytuł oryginału: Interaction of zinc with antidepressants in the forced swimming test in mice.
    Autorzy: Szewczyk Bernadeta, Brański Piotr, Wierońska Joanna M., Pałucha Agnieszka, Pilc Andrzej, Nowak Gabriel
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.681-685, tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Recent preclinical data have suggested that glutamate NMDA receptor may be involved in the mechanism of action of antidepressant treatments. Functional antagonists of the NMDA receptor complex exhibit an antidepressan-like effect in animal tests that predict antidepressant activity and in animal models of depression. Zinc, a very potent inhibitor of the NMDA receptor, is active in the forced swimming test in rats and mice. The present study investigated the interaction of zinc with antidepressants in the forced swimming test in mice. Mice were injected with imipramine or citalopram alone and in combination with zinc. Low, ineffective per se doses of imipramine and citalopram administered together with low, ineffective doses of zinc were active in this test. The present data support the notion that inhibition of the NMDA receptor participates in an antidepressant action, and further demostrate particular role of zinc in this activity.


    2212/2523

    Tytuł oryginału: Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats.
    Autorzy: Filip Małgorzata, Papla Iwona, Czepiel Klaudia
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.687-691, il., bibliogr. 27 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny
  • komunikat

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: It is established that dopamine (DA) is an important brain mediator of the behavioral (i.e. sensitizing) effects of cocaine in rodents. Among DA receptor, recent findings point to engagement of DA D3 receptors in cocaine addictive actions. In the present study, we attempted to determine the role of DA D3 receptors in the expression phase of sensitization to cocaine in rats, using the selective ligands 7-OH-PIPAT (an agonist) and nafadotride (an antagonist) of these receptors. Repeated administration (1-5 days) of cocaine (10 mg/kg, ip) to male Wistar rats significantly enhanced the locomotor activation induced by its challenge dose given after 5-day withdrawal (on day 10). 7-OH-PIPAT (1 mg/kg, but not 0.01-0.1 mg/kg, sc) administered together with a challenge dose of cocaine significantly decreased the response to cocaine in rats treated repeatedly with cocaine. On the other hand, the expression of cocaine sensitization was increased when that drug was combined with nafadotride (0.4 mg/kg, ip) on day 10. The results indicate a role of DA D3 receptors in controlling the expression of cocaine sensitization in rats, and may suggest an importance of DA D3 receptor agonists in the therapy of cocaine abuse.


    2213/2523

    Tytuł oryginału: Influence of pre- and intraoperational use of tramadol (preemptive or preventive analgesia) on tramadol requirement in the early postoperative period.
    Autorzy: Wordliczek Jerzy, Banach Marcin, Garlicki Jarosław, Jakowicka-Wordliczek Joanna, Dobrogowski Jan
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.693-697, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • chirurgia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study was to assess the influence of iv tramadol on opioid requirement in the early postoperative period. The subjects were 90 patients scheduled for colon surgery (hemicolectomy) who received general anesthesia using the (N2O/O2) isoflurane technique. Thirty patients (group I) were administered 100 mg of tramadol iv before induction of general anesthesia (preemptive analgesia). Group II (30 patients) was administered 100 mg of tramadol iv immediately after peritoneal closure (preventive analgesia) and control group (30 patients) received 100 mg of tramadol iv immediately after operation. Following the operation, all patients were administered tramadol in the PCA-iv mode in order to treat postoperative pain. In the postoperative period, the following parameters were measured: pain intensity (using VAS), total consumption of tramadol, time until the first PCA activation, and frequency of side effects (drowsiness, nausea, vomiting). In patients of groups I and II who had received preemptive or preventive analgesia, a significantly lower total consumption of tramadol, as compared with control group, was observed in the early postoperative period. However, the time until the first PCA activation was significantly shorter in group I as compared to the other two groups. No significant differences between the groups were found regarding pain intensity and frequency of side effects.


    2214/2523

    Tytuł oryginału: Effects of combined treatment with selective sigma ligands and amantadine in the forced swimming test in rats.
    Autorzy: Skuza Grażyna, Rogóż Zofia
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.699-702, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The obtained results showed that the selective simga 1 receptors agonist, SA4503 (but not siramesine, the sigma 2 receptor agonist), given alone, exerted an antidepressant- like activity in the forced swimming test in rats. Amantadine (an uncompetitive NMDA receptor antagonist) potentiated or revealed the effect of SA4503 or siramesine, respectively, in this model.


    2215/2523

    Tytuł oryginału: Effect of joint administration of imipramine and amantadine on binding of [3H]7-OH-DPAT to dopamine D3 receptors in peripheral blood lymphocytes of the patients with drug-resistant unipolar depression.
    Autorzy: Dziedzicka-Wasylewska Marta, Rogóż Zofia, Solich Joanna, Dudek Dominika, Wróbel Andrzej, Zięba Andrzej
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.703-706, il., bibliogr. 13 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Treatment of the patients suffering from therapy-resistant unipolar depression with joint administration of imipramine (twice daily, 100-150 mg/day) an amantadine (twice daily, 150 mg/day) for four to six weeks resulted in the significant increase in the binding of [3H]17-OH-DPAT to dopamine D3 receptors in the peripheral blood lymphocytes. This effect correlated well with the clinical improvement, estimated with Hamilton's Depression Rating Scale. In the light of the above data, it seems justified to postulate that joint therapy with imipramine and amantadine may be successful in the treatment-resistant unipolar depression.


    2216/2523

    Tytuł oryginału: Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.
    Autorzy: Tatarczyńska Ewa, Pałucha Agnieszka, Szewczyk Bernadeta, Chojnacka-Wójcik Ewa, Wierońska Joanna, Pilc Andrzej
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.707-710, tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.


    2217/2523

    Tytuł oryginału: Effect of antidepressant drugs on the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells.
    Autorzy: Budziszewska Bogusława, Jaworska-Feil Lucylla, Tetich Małgorzata, Basta-Kaim Agnieszka, Kubera Marta, Leśkiewicz Monika, Lasoń Władysław
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.711-716, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • genetyka
  • endokrynologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid. Forskolin (an activator of adenylate cyclase), but not phorbol 12-myristate 13-acetate (an activator of protein kinase C), ca. 3-fold increased reporter gene activity, which confirms the critical role of the cAMP-responsive element in regulation of the CRH gene. Imipramine and fluoxetine present in the medium for 5 days, in a concentration-dependent manner (3-30 ćM) inhibited the basal acitivity of CRH gene promoter, while tianeptine was inactive. The obtained results indicate that inhibition of the human CHR gene promoter activity by imipramine and fluoxetine, but not tianeptine, may play a role in mechanism by which the former drugs attenuate HPA axis activity.


    2218/2523

    Tytuł oryginału: Rapid desensitization of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) in chick cerebral cortex.
    Autorzy: Niewiadomski Paweł, Nowak Jerzy Z., Sędkowska Paulina, Zawilska Jolanta B.
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.717-721, il., bibliogr. 13 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • ptaki

    Streszczenie angielskie: Pituitary adenylate cyclase-activating polypeptide (PACAP38) potently stimulates cyclic AMP formation in slices of chick cerebral cortex. One- to fifteen-minute pretreatment of slices with 30 nM PACAP38 led to a time-dependent attenuation (when compared with values observed in the control tissue) of the cyclic AMP response produced by subsequent re-stimulation with 1 ćM PACAP38. Concentration-response curve for restimulation with PACAP38 applied at 0.01 - 1 ćM to tissue slices preincubated for 15 min with 30 nM PACAP38 revealed dose-dependent decreases in subsequent cyclic AMP responses by 16-37 p.c. It is concluded that in chick cerebral cortex, the receptors mediating PACAP-driven cyclic AMP responses (PACAP1 receptors) undergo rapid homologous desensitization.


    2219/2523

    Tytuł oryginału: Effect of some iono- and metabotropic glutamatergic ligands on neuropeptide Y immunoreactivity in the rat hippocampus.
    Autorzy: Śmiałowska Maria, Wierońska Joanna M., Szewczyk Bernadeta, Obuchowicz Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.723-726, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The effect of some agonists and antagonists of glutamatergic receptors (GluR) on neuropeptide Y (NPY) level in the rat hippocampus was investigated using radioimmunoassay method. The compounds were injected intraperitoneally (NMDA, ACPC and MPEP) or intrahippocampally (L-CCG, L-SOP, AIDA). It was found that NMDA induced a decrease in NPY-IR in the hippocampus. No significant changes were found after ACPC (a functional NMDA receptor antagonist) and MPEP (mGlu5 receptor antagonist). NPY-IR was significantly increased after intrahippocampal injections of group II and III mGluR agonists (L-CCG-I and L-SOP, respectively) as well as after group I mGluR antagonist AIDA. The obtained results indicate that glutamatergic metabotropic and NMDA receptors may regulate NPY expression in the hippocampus. This regulation may have some connection with modulation of anxiety by the studied compounds.


    2220/2523

    Tytuł oryginału: Neuroprotective effects of estrone of NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors.
    Autorzy: Kajta Małgorzata, Lasoń Władysław, Bień Ewa, Marszał Michał
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.727-729, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • zarodki
  • in vitro

    Streszczenie angielskie: It has been hypothesized that some estrogenic metabolites with low hormonal activity, such as estrone or estriol, may serve as endogenous neuroprotective agents. Since estrone naturally occurs in abundance in the human brain, we evaluated its effects on the NMDA-induced toxicity in primary cultures of the rat cortical neurons. The results showed that NMDA (1 mM) had toxic effect on the rat cortical neurons on 12, but not on 7 day in vitro. This effect was partially prevented by DL-2-amino-5-phosphonovaleric acid (AP-5), a competitive NMDA receptor antagonist. Estrone (500 nM) attenuated the NMDA-induced toxicity in estrogen receptor-independent way. These data support the hypothesis that toxic effects of NMDA depend on stage on neuronal development and point to non-genomic neuroprotective actions of estradiol metabolites.


    2221/2523

    Tytuł oryginału: Influence of new ç-hydroxybutyric acid amide analogues on the central nervous system activity in mice.
    Autorzy: Sałat Kinga, Mendyk Anna, Librowski Tadeusz, Czarnecki Ryszard, Malawska Barbara
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.731-736, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The present study investigates the activity of four ç-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the ç-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice.


    2222/2523

    Tytuł oryginału: Effect of some antipsychotic drugs on immunoreactivity in C57BL/6 mice.
    Autorzy: Basta-Kaim Agnieszka, Kubera Marta, Budziszewska Bogusława, Siwanowicz Joanna, Lasoń Władysław
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.737-742, il., bibliogr. 24 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The study examined the effect of some typical and atypical antipsychotic drugs on mouse lymphocyte metabolic and proliferative activity in vitro. The typical antipsychotic drug chlorpromazine (3 x 10**-6, 10**-5 and 10**-4M), significantly inhibited 3H-thymidine incorporation into C57BL/6 mouse spleen cells stimulated by concanavalin A (ConA), lipopolisaccharide (LPS) or pokeweed mitogen (PWM). Chlorpromazine at concentrations of 10**-5 and 10**4 M also suppressed the metabolic activity of splenocytes after ConA stimulation. The atypical antipsychotic agent clozapine (10**-4 and 10**-5 M) decreased the proliferative activity of spenocytes after LPS stimulation, but its inhibitory effect after ConA was observed only at higher concentrations. On the other hand, clozapine did not affect the metabolic activity of splenocytes. Sulpride, a selective dopamine D2 antagonist, at concentrations ranging from 10**-8 to 10**-4 M had no inhibitory effect on the proliferative or metabolic activity of the tested cells. The obtained results indicate that of the three antipsychotic drugs studied, chlorpromazine shows the most potent immunosuppressive effect, clozapine produces a moderate effect and sulpride is totally inactive. These findings suggest that the choice of antipsychotic drugs should also depend on disturbance of immune system activity, in particular those occurring in the several forms of psychosis.


    2223/2523

    Tytuł oryginału: An analysis of prognostic factors and the five-year survival rate in childhood acute lymphoblastic leukemia.
    Autorzy: Karimi Mehran, Yarmohammadi Hooman, Sabri Mohammad R.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR792-CR796, tab., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Acute Lymphobastic Leukemia (ALL) is the most common malignancy in childhood. With newer drug protocols the five-year survival rate is now close to 80 p.c. Various factors have been reported to be important for prognosis and should be considered when planning treatment. Material/Methods: In a cross-sectional study, prognostic variables and the five-year survival rate were analyzed. Data regarding demographic characteristics, family and personal history, manifestations at the time of presentation, therapeutic regimens and outcome were collected from the records of 76 ALL patients in the treatment five years prior to the study. Two pathologists performed the staging using the morphology method (L1, L2 and L3). Results: Fifty-five subjects (72.5 p.c.) survived until the end of the study. One subject succumbed to the rapid fatal course of the disease and 20 others passed away due to relapses or infection during follow-up. Conclusion: Among all variables a worse prognosis was associated (p 0.05) wiht WBC counts greater than 50.000/ml at presentation, relapse in the CNS, and relapse in the bone marrow. When Anthracycyline was included in the therapeutic regimen, the effect of chemotherapy was more favorable compared to regimens without Anthracycline (p 0.05). Other variables previously reported to have prognostic value, especially age and sex, were not significantly in our study (p 0.05). Other factors which might account for a poorer included the preponderance of L2 morphology, difficult assess to medical care, decreased compliance of families due...


    2224/2523

    Tytuł oryginału: Prevalence of hepatitis B and C seromarkers and abnormal liver function tests among hemophiliacs in Guilan (northern province of Iran).
    Autorzy: Mansour-Ghanaei Fariborz, Fallah Mohammad-Sadegh, Shafaghi Afshin, Yousefi-Mashhoor Mahmood, Ramezani Naghi, Farzaneh Farshid, Nassiri Reza
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR797-CR800, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • mikrobiologia
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to determine the seroprevalence of hepatitis B and C viruses and abnormal liver function tests among hemophiliacs in Guilan province, Iran. Material/Methods: Patients registered with Guillan Hemophilia Society (GHS) were enrolled in this study, and evaluated for the presence of hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV-Ab) and liver function tests. Results: One hundred and one patients (100 males, 1 female aged 19.7 years) from 110 registered hemophiliacs were enrolled in this study. 29 patients (28.7 p.c.) had elevated Alanine aminotransferase (ALT), 27 (26.7 p.c.) and 72 (71.3 p.c.) were positive for HBsAg and HCV-Ab, respectively. Seropositively for HCV-Ab correlated with the duration of treatment with clotting factor until 1997 (P = 0.01). There was also an inverse correlation between factor VIII and IX activity and seroporistively for HCV-Ab (P 0.001) and HBsAg (P 0.04). HCV-Ab was more likely to be positive among those received lyophilized factor VIII and cyroprecitate than hyophilazed factor VIII alone (P 0.01). In addition HCV-Ab seropositively was more commong among those received factor IX concentrate and fresh frozen plasma (FFP) than those received only FEP (P 0.01). Conclusion: Based upon our finding, prevalence of HBsAg positive cases in Guilan province was higher than other studies. Altough frequency of HCV-Ab was similar to other studies, frequency of increases ALT was less. Upon the results emerged from this study, we recommended that all hemophiliacs should be vaccinated against HBV...


    2225/2523

    Tytuł oryginału: Experience with cerebral perfusion in total aortic arch replacement.
    Autorzy: Apaydin Anil Z., Islamoglu Fatih, Iyem Hikmet, Posacioglu Hakan, Yagdi Tahir, Bket Suat
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR801-CR804, tab., bibliogr. 10 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The interruption of cerebral circulation is a major problem in the surgical repair of the aortic arch. This study was undertaken to identify the periooperative risk factors for mortality and neurological morbidity, and the outcome after total aortic arch replacement. Material/Methods: Between June 1995 and March 2002, 23 patients (13 males) underwent total aortic arch replacement. The mean age was 61.7 ń 9.4 years (range 35-77). All patients underwent total arch replacement with a period of hypothermic circulatory arrest (HCA). Selective cerebral perfusion was utilized as an ajunct to HCA (retrograde in 19 patients and antegrade in 4 patients). The elephant trunk technique was used in 18 patients, while proximal and middle portion of the descending aorta was also replaced in 5 patients. The patient information in our database was retrospectively reviewed. The risk factors affecting mortality and morbidity were analyzed by univariate analysis. Results: The in-hospital mortality rate was 17.4 p.c. None of the survivors developed major stroke. Temporary neurological dysfunction (TND) was seen in 5 patients. Univariate analysis revealed that excessive blood transfusion was the only factor correlated with hospital death among 18 perioperative variables (p 0.006). HCA lasting ň 55 minutes and a history of hypertension were associated with the development of TND (p 0.032 and p 0.02, respectively). Conclusion: Total arch replacement can be performed with acceptable mortality and neurological morbidity. Midterm survival is excellent in hospital survivors...


    2226/2523

    Tytuł oryginału: A longitudinal study of the efficacy of interferon therapy in children with chronic hepatitis B.
    Autorzy: Kacprzak-Bergman Irma, Zaleska Izabela, Gruszka Jarosław, Jasonek Jolanta
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR805-CR814, il., tab., bibliogr. 65 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Interferon alpha (IFN) is the most effective drug in the treatment of chronic hepatitis B. This article presents the results of IFN therapy and 28-month follow-up. Material and methods: 193 Caucasian children (130 boys and 63 girls) aged 1.5 - 17 years were treated with IFN for 20 weeks (3.0 MIU 3 times a week). They were examined at baseline (period 0), after 6 weeks (period 1), 12 weeks (period 2), 20 weeks (period 3), 6 months (period 4), 12 months (period 5), 18 months (period 6), and 24 months (period 7). Results: HBcAg elimination drom period 3 was: 29.6 p.c., 35.2 p.c., 45.4 p.c., 58.3 p.c., in period 7 63.9 p.c. (significantly higher in girls). Significant positive correlations were found in several periods between IFN/mý and HBeAg, HBsAg elimination, HBsAb, HBsAb presence and negatie correlations between IFN/mý and ALT activity. ALT activity significantly decreased in girls between periods 0-3, in boys between 0-3 and 4-6. Significant positive correlations between ALT-0 and HBeAg, HBsAg elimination, HBeAb, HBsAb presence was seen in several periods, more frequently in girls. IFN transiently decreased Hb, leucocytes, and thrombocytes, especially in boys. No relationship was found between IFN therapy and bilirubin, protein, albumin and gammaglobulin concentrations. The prothrombin index increased after 6 months of IFN therapy in girls. Conclusions: The efficacy of IFN therapy is clearer with longer observation, especially in girls. A relationship was found between IFN dose and HBeAg/HbeAb and HBsAg/HBsAb seroconversion. IFN had a transient negative effect on the peripheral blood picture.


    2227/2523

    Tytuł oryginału: Cytomegalovirus disease in neonates and infants - clinical presentation, diagnostic and therapeutic problems - own experience.
    Autorzy: Liberek Anna, Rytlewska Marlena, Szlagatys-Sidorkiewicz Agnieszka, Bako Wanda, Łuczak Grażyna, Sikorska-Wiśniewska Grażyna, Korzonut. Maria
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR815-CR820, il., bibliogr. 23 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the study was to present diagnostic problems, different clinical presentations and results of treatment of cytomegalovirus infections in neonates and infants. Material and methods: The study was carried out in a group of 31 children from 10 days to 12 months of age (17 boys, 14 girls). The diagnosis was based on serological investigations (presence of specific IgM antibodies and/or increasing titer of IgG antibodies), presence of intermediate or early CMV antigen in peripheral blood leukocytes or positive blood or urine PCR results. The treatment of 25 cases involved intravenous administration of gancyclovir at 5-7 mg/kg daily doses for 14-21 days. In 1 case, hyperimmunized anti-CMV serum - Cytotect was used. Results: The most common clincal symptoms were jaundice, hepato- and splenomegaly. Clinical investigations demonstrated increased aminotransferase activity and the signs of cholestasis. Other frequent findings included anemia, leukocytosis with atypical lymphocyte forms present, as well as thrombocytopenia. In majority treated patients, rapid regression of the clinical symptoms and normalization of transaminases activity was observed. Good outcome of the therapy was confirmed by immunological investigations. The effecst of the therapy were similar irrespective of the dosee and duration of gancyclovir treatment. The tolerance of the drug was good - no indications for discontinuation of the treatment were observed in any of the patients. Conclusions: The clinical presentations of cytomegalovirus disease in infants are varied, the diagnosis...


    2228/2523

    Tytuł oryginału: Autoantibodies in children with chronic hepatitis B undergoing interferon therapy.
    Autorzy: Kacprzak-Bergman Irma, Zaleska Izabela, Gruszka Jarosław, Kuchar Ernest
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR821-CR824, tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • toksykologia
  • immunologia
  • mikrobiologia
  • gastroenterologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The occurence of varios side effects in patients treated with interferon alpha has attacted more attention to the manifestation of autoantibodies. The purpose of our study was to evaluate the side effects of interferon in children suffering from chronic hepatitis B by detecting six autoantibodies. Material/methods: Autoantibodies were examined in 76 children (55 boys and 21 girls) aged 2-16 years, treated with interferon-alpha 3 MU 3 times weekly for 20 weeks. They were tested before treatment (exam 1) and after its conclusion (exam II). SMAs were determined by indirect immunofluorescence (Euroimmuno reagents), while ANA, AMA M2, GPC, TPO and ATG were measured by EIA (Biomediaca reagents). Results: No statistically significant differences were found between the total number of patients with autoantibodies in examination I and examination II. A comparison of the frequency of presence or absence of autoantibodies in the same patients in exams I and II showed significantly more frequent disappearance of GPC in exam II than appearance (p 0.00005). This was also observed in the case of TPO (p = 0.320). In relation to ANA, SMA, AMA M2 and ATG these differences were not significant. Conclusions: INF-alpha does not induce autoantibody formation in children with chronic hepatitis B. Our results suggest that IFN-alpha may inhbit the formation of some autoantibodies.


    2229/2523

    Tytuł oryginału: Totally endoscopic bilateral internal thoracic artery bypass grafting in a young diabetic patient.
    Autorzy: Dogan Selami, Aybek Tayfun, Khan Mohammad Fawad, Neidhard Gerd, Auch-Schwelk Wolfgang, Moritz Anton, Wimmer-Greinecker Gerhard
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CS95-CS97, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The introduction of robotics into cardiosurgical practice in 1998 has enabled totally endoscopic closed chest procedures. Totally endoscopic grafting of the LAD (TECAB) is no longer an experimental procedure. Case report: We report on case with totally endoscopic bilateral thoracic artery bypass grafting to the left anterior descending and right coronary artery in a 36-year-old obese female diabetic patient using the daVinci surgical system. The patient, suffering from juvenile diabetes for 26 years, presented with stable angina (CCS class II). A coronary angiogram revealed 2-vessel disease with a long complex proximal lesion of the left anterior descending artery (LAD) (90 p.c.) and 80 p.c. stenosis of the proximal right coronary artery (RCA). Due to the condition of the proximal LAD (high risk PTCA with rather poor prognosis), the patient was referred for minimally invasive operative revascularization of the LAD and the RCA. After informed consent was obtained the patient underwent totally endoscopic double internal thoracic artery bypass revascularisation on the arrested heart using computer-enhanced telemanipulation technology. Conclusion: The feasibility and safety of successful closed chest, totally endoscopic double coronary bypass grafting with two internal thoracic arteries is demonstrated in this case. Preservation of a stable chest cavity and reduced risk for wound healing complications in diabetics with an excelent cosmetic result are the obvious advantages of the techniques described.


    2230/2523

    Tytuł oryginału: Recombinant Coagulation Factor VIIa for rapid preoperative correction of Warfarin-related coagulopathy in patients with acute subdural hematoma.
    Autorzy: Veshchev Igor, Elran Hanoch, Salame Khalil
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CS98-CS100, bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Intracranial hemorrhage, either spontaneous or traumatic is a well-known and potentially lethal complication of Warfarin treatment. Patients with Warfarin-related intracranial hemorrhage need urgent reversal of anticoagulation that must be especially rapid if surgical intervention is indicated. The traditional treatment with fresh frozen plasma (FFP) and vitamin K often fails to achieve the desired correction of coagulopathy in urgent neurosurgical settings. Case report: In the present case Recombinant Coagulation Factor VIIa (rFVIIa) was used for preoperative reversal of Warfarin-related coagulopathy. The patient was a fifty two years old man, mechanic valve recipient with Warfarin-induced coagulopathy: International Normalization Ratio (INR) of 6.39, who suffered from acute subdural hematoma and needed urgent neurosurgical intervention. He received a single dose of rFVIIa 120 ćg/kg and immediately underwent craniotomy and evacuation of the hematoma. Appropriate hematostasis was achieved durring surgery and coagulation test taken two hours after rFVIIa injection revealed INR of 1.25. The INR remained nromalized for additional 14 hours. To the best of our knowledge, this is the first report on the use of rFVIIa in the preoperative management of Warfarin-induced intracranial hemorrhage. Conclusion: Recombinant Coagulation Factor VII provides rapid correction of coagulation to a level that allows safe neurosurgical intervention without significant delay. This agent is safe and effective; and should be considered for reversal of Warfarin-induced coagulopathy...


    2231/2523

    Tytuł oryginału: Detection of Cryptosporidium parvum infection in childhood using various techniques.
    Autorzy: Doganci Tumay, Araz Engin, Ensari Arzu, Tanyuksel Mehmet, Doganci Levent
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.MT223-MT226, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The protozoan parasite Cryptosporidium parvum, which causes acute gastroenteritis in both humans and animals, has become an important pathogen all over the world. C. parvum may cause asymptomatic or symptomatic acute infections of the digestive system in immunocompetent subjects, but life-threating disease in immunocompromised hosts. The aim of this study was to determine the usefulness of conventional microscopic staining techniques in the detection of C. parvum. For this purpose, 50 unselected immunocompetent asymptomatic children were evaluated for C. parvum during routine upper endoscopy. Material and methods: Duodenal aspirates and duodenal biopsy samples from 37 girls and 13 boys, between the ages of 2 and 18 years, obtained by gastrointestinal upper endoscopy and concomitant stool samples were examined with different staining techniques. Results: Two stool samples and one duodenal aspirate were positive for C. parvum, but we could not demonstrate C. parvum in any duodenal biopsy samples. Dyspepsia was the primary indication for upper endoscopy in the patient with positive duodenal aspirate sample. Conclusion: These findings indicate that there is a low asymptomatic carrier rate in immunocomponent subjects with no involvement of intestinal villius attachment in the duodenum. We also conclude that C. parvum is an infrequent parasite in asymptomatic subjects, most probably due to a very low prevalence of HIV positivity in Turkey.


    2232/2523

    Tytuł oryginału: Music as an aid in the development of the social self.
    Autorzy: Salamon Elliott, Stefano George B., Kim Minsun
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.SR35-SR38, bibliogr. 12 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The development of the social self has been a topic of interest to developmental psychologists for some time. With the recent emphasis placed on the effect of the nuclear family and its increasing paucity, researches have been even more pressed to develop alternative means to aid in the social effects of family and subsequently enhance a child's assertion of independence. In our paper we explore some of the possible ways by which developmental learning occurs, most notably by implicit or unconscious acquisition. We further provide some historical background explaining the emergence of this unconsious learning. Once we understand the process by which this learning occurs and the historical context in which it operates we can put forth our hypothesis. We suggest that an effective way of aiding or supplementing the role of the family is by providing a theoretical family unit. Specifically we purpose that participation n musical or band related activities aids in the emergence of adolescence independence and a healthy self concept.


    2233/2523

    Tytuł oryginału: Psychosocial factors in chronic disability.
    Autorzy: Pearce J. M. S.
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.RA275-RA281, bibliogr. 45 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: If adopted without adequate cause, the lifestyle of an invalid is a grave misfortune for the patient and for its reflection on current social attitudes that foster such states. Psychological illnesses are frequently invoked and are often of genuine source of suffering and disability. However, patients who may be rewarded by large financial settlements in courts, may also on occasion exaggerate their claims. Modern society has established systems of support, and rulings in court proceedings that conduce to illness behaviour. To some extent the portentous diagnostic labels given to these patients fosters rather than alleviates illness. It is probable that biological factor deriving from the primary event initiate the process. In medical terms, the symptoms and disabilities are often discrepant with the initial illness or injury. The patients' behaviour arises out of a desire to attaim the sick for secondary gain. If society eliminated th stigma of psychological illness, and opposed exaggregation and stimulation of illness, then such chronic disability with 'retreat into illness' might disappear. Sometimes an assumed illness becomes an adopted way of life. The unfortunate patients may come to believe they are ill; symptoms then persist after settelement. It is wrong to blame everything on society and to deny the free choice of the individual. Nevertheless, the pressures of society can be difficult to withstand for those no gifted with resillence. We should also recognise and try to eliminate the contribution mady by doctors and health workers who mistakenly aid and...


    2234/2523

    Tytuł oryginału: Leptin - from a signal of adiposity to a hormonal mediator in peripheral tissues.
    Autorzy: Baratta Mario
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.RA282-RA292, bibliogr. 171 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The biology of leptin has been studied most extensively in the central nervous system for the regulation of food intake and energy balance. In recent years, a growing number of publications have reported several activities of this adipose-secreted protein in different organs. These effects appear to be independent of the regulation of food intake or at least not directly correlated to it, but rather related to the hormonal regulation of these particular tissues. Thus leptin is now also considered to be a hormonal factor that informs several hormonal circutis and biological peripheral functions of the nutrition status of the organism. Different systems are involved in leptin activity, such as a pituitary, male and female reproductive organs, the mammary gland, the immune system, the gut, the kidney and the lung. Functional leptin receptors and/or leptin protein have been shown to be expressed in these tissues. Furthermore, interesting interactions have been reported with classical hormones involved in the regulation of activities in such organs. These observations give more detailed activity evidence of the relationship between nutrition and tissue differentiation in peripheral sites, possibly mediated by classical hormonal circuits. This work aims to review the most important functional findings on leptin's effects in these peripheral sites, and potential future studies are suggested based on currently available data.


    2235/2523

    Tytuł oryginału: Multiple extrarenal complications of Wegener's granulomatosis.
    Autorzy: Rihova Zuzana, Merta Miroslav, Rysava Romana, Bezdicek Petr, Danzig Vilem, Gorican Karel, Lukas Jindrich, Skalicka Pavlina, Vernerova Zdenka, Tesar Vladimir
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.1-4, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 313,612

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: We describe a sace of Wegener's Granulomatosis (WG), a diseases characterized by necrotizing granulomatous lesions and vasculitis of the upper and lower respiratory tract, necrotizing glomerulonephtitis with crescent formation and systemic vasculitis. Case report: The patients initially presented with a corneal perforation. In addition to the eye involvement, multiple other organ involvement was found during the course of the disease. The renal biopsy showed a pauciimmune necrotizing glomerulonephtitis with occlusive fibrocellular crescents, the interstitium was focally fibrotic with the skin vasculitis and arthralgias. Cardiac involvement included an acute myocardial infaraction and aortic valve vegetation, most likely caused by WG. Another complication during the initial presentation was a massive intestinal bleeding. The diagnosis of WG was established by renal, conjunctival and upper airway biopsies and by positive c-ANCA. The clinical and laborotory remission of the disease was achieved by combined immunosuppressive therapy with cyclophosphamide and corticosteroids. Later in the course of the disease the patient developed a subglottic stenosis, most probably due to reparative changes. Conclusions: In conclusion, this is a case of WG with multiple extrarenal complications, that had a grave clinical course.


    2236/2523

    Tytuł oryginału: Early neonatal diagnosis of maternal renal compromise.
    Autorzy: Narchi Hassib, AbuKhalil Emad
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.5-7, il., bibliogr. 6 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • nefrologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Neonatal illness may occasionally lead to the diagnosis of a yet undiagnosed maternal illness, such as neonatal heart block and maternal systemic lupus erythematosus or neonatal hypotonia and maternal myotonic dystrophy. It is however very rare to diagnose a significant medical problem in the mother of an otherwise healthy newborn. Case report: A 36-year-old woman withy earlier episodes of hyperemesis requiring intravenous rehydration was admitted at 33 weeks of gestation in spontaneous labour. The newborn developed mild abdominal distension and vomiting the age of 12 hours. Physical examination and uring output were normal and there was no haematuria or proteinuria. Serum urea and creatinine were elevated. Vomiting did not recur, feeds were resumed and the rest of her clinical course was uneventful. Serial blood biochemistry results showed progressive normalisation of serum creatinine and urea. The child's mother soon developed recurrent vomiting few hours after birth and was found to be clinically dehydrated, oliguric but normotensive. Serum creatinine and urea were elevated. Following intravenous rehydration, urine output and serum biochemistry improved over the next few days. Conclusions: Estimation of plasma creatinine and serum electrolytes is not indicated in the newborn soon after birth. However, abnormal results may serendipitously diagnose maternal renal dysfunction.


    2237/2523

    Tytuł oryginału: Case of Cushing's syndrome due to ACTH-independent bilateral micronodular adrenal hyperplasia presenting as a severe myopathy with diaphragm atrophy.
    Autorzy: Kaźmierczak Sylwia F., Zieleniewski Wojciech, Kołomecki Krzysztof, Kunert-Radek Jolanta
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.8-11, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The most typical presentation of Cushing's syndrome includes truncal obesity, purple skin striae, moon face, emotional and sleep disturbances, plethora and proximal muscle weakness. ACTH-independent micronodular adrenocortical hyperplasia (AIMAH) is a rare cause of Cushing's syndroeme with male predominance. We describe here a female patient with atypical Cushing's syndrome due to AIMAH presenting as a severe myopathy with diapghragm atrophy. Case report: A 56-year-old female suffered from hypertension, NIDDM, central adiposity and muscle weakness for 5 years, but her appearance was not typically cushingoid. She was admitted to hospital because of respiratory insufficiency due to diaphragm atrophy. Reconstructive surgery of the diaphragm was performed, but without any significant improvement. Six months later, she was referred to us with suspicion of Cushing's syndrome. Her ACTH levels in plasma samples collected throughout the day were below normal. The cortisol level was at upper limit of the normal range. The plasma circadian cortisol profile was blunted and 1 mg dexamethasone did not induce any inhibition of serum cortisol. The subsequent administration of 8 mg of dexamethasone did not cause any further suppression of cortisol. While these findings were consistent with a diagnosis of adrenocortical adenoma, computed tomography demonstrated slightly enlarged, contrast-enhacned adreanls (both adrenal glands). Results: ACTH-independent Cushing's syndrome was diagnosed and the patient underwent bilateral adrenalectomy. Histological studies revealed bilateral micronodular adrenal hyperplasia. Soon after the surgery the woman became hypoadrenal...


    2238/2523

    Tytuł oryginału: Late onset neonatal group B streptococcal disease: not predictable by early cultures and not preventable by early antibiotic therapy.
    Autorzy: Narchi Hassib, Gowan-Gopal Nenisha
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.12-15, bibliogr. 38 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Background: Most cases of neonatal Group B streptococcus (GBS) infections are of early onset and the risk factors and preventive measures are well defined. Late onset disease is rarer, risk factors are less well known and no preventive measures can be recommended. Case report: Late onset GBS meningitis developed in a neonate without maternal colonisation. There was no bacteriological evidence of early neonatal colonisation or infection. The neonate had also received antibiotics in the first few days of life. Conclusions: absence of maternal or perinatal risk factors should not preclude GBS when prescribing antibiotic therapy in late onset neaonatal sepsis, even if prior antibiotics had been administered. The chosen antibiotic treatment should always be adwquate to treat a systemic infectionwith GBS.


    2239/2523

    Tytuł oryginału: Sentinel node detection in skin melanoma patients with the use of lymphoscyntigraphy, intraoperative dye mapping and hand - held gamma probe radiation detector.
    Autorzy: Nejc Dariusz
    Źródło: Ann. Acad. Med. Lodz. 2002: 43 (3) s.5-7, bibliogr. 10 poz.
    Sygnatura GBL: 702,574

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • streszczenie
  • praca doktorska
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska


    2240/2523

    Tytuł oryginału: Diagnosis of vestibular schwannoma based on audiological tests, radiological investigations and vestibular evoked myogenic potentials.
    Autorzy: Morawiec-Bajda Alina, Olszycki Marek, Pietruszewska Wioletta, Góraj Bożena, Gryczyński Maciej
    Źródło: Ann. Acad. Med. Lodz. 2002: 43 (4) s.17-24, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 702,574

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia
  • radiologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska


    2241/2523

    Tytuł oryginału: Curricular requirements for midwives in England.
    Tytuł polski: Wymagania programowe dla położnych w Anglii.
    Autorzy: Iwanowicz-Palus Grażyna J., Wrońska Irena, Lewicka Magdalena
    Źródło: Ann. Acad. Med. Lodz. 2002: 43 (4) s.35-38, bibliogr. 6 poz., streszcz. - Ogólnopolska konferencja naukowa pt. Nowe wyzwania akademickiego kształcenia pielęgniarek i położnych Lublin 06-07.12. 2002
    Sygnatura GBL: 702,574

    Hasła klasyfikacyjne GBL:
  • pielęgniarstwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca przeglądowa
  • tytuł obcojęzyczny


    2242/2523

    Tytuł oryginału: Gram-negative folliculitis - a diagnostic challenge.
    Tytuł polski: Zapalenie mieszków włosowych wywołane bakteriami Gram-ujemnymi - wyzwanie diagnostyczne.
    Autorzy: Tarlow Mordechai M., Piela Zofia, Schwartz Robert A.
    Źródło: Dermatol. Klin. 2002: 4 (1/4) s.7-9, bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 313,522

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Zapalenie mieszków włosowych wywołane zakażeniem bakteriami Gram-ujemnymi jest rzadkim, lecz istotnym schorzeniem, będącym powikłaniem przewlekłej antybiotykoterpii trądziku pospolitego lub trądziku różowatego. Choroba powinna być podejrzewana u osób z trądzikiem guzkowo-cystowym lub trądzikiem różowatym, które nie reagują na przewlekłą antybiotykoterapię lub u których po początkowej poprawie następuje gwałtowne pogorszenie stanu klinicznego. Leczenie polega na stosowaniu izotretynoiny celem eradykacji drobnoustrojów. U osób niekwalifikujących się do tego typu terapii można sotsować przez długi okres celowaną antybiotykoterpię. W pracy dokonano przeglądu patofizjologii, obrazu kliniczneog i możliwości terapeutycznych tego schrozenia.

    Streszczenie angielskie: Gram-negative folliculitis is an uncomon but important complication of the treatment of acne or rosacea. This disease entity should be considered in patietns who have had persistent nodulocystic acne or rosacea that has not been responding to longstanding antimicrobial therapy, as well as in those responding to treatment who then have a sudden flare. Treatment consists primarily of isotretinoin therapy to eradicate the organisms. In patietns who are not a candidate for this agent longterm suppression with appropriate antibiotics is necessary. This article reviews the pathophysiology, clinical presentation, diagnosis and treatment of this disorder.


    2243/2523

    Tytuł oryginału: Current management of leprosy reactions.
    Tytuł polski: Współczesne leczenie reakcji trądowych.
    Autorzy: Arenas Roberto, Ruiz-Esmenjaud Julieta
    Źródło: Dermatol. Klin. 2002: 4 (1/4) s.11-15, il., bibliogr. 33 poz., streszcz.
    Sygnatura GBL: 313,522

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • farmacja
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Łagodne reakcje w trakcie leczenia (reversal reaction) w przebiegu trądu wymagają jedynie leczenia objawowego z zastosowaniem leków przeciwbólowych, natomiast w przypadku ciężkich reakcji lekiem z wyboru jest doustnie podawany prednizon lub prednizolon. Początkowa dawka wynosi 1 mg/kg m.c./dzień (60-80 mg/dzień) i powinna być utrzymana przez co najmniej tydzień. Podawanie kortykosteroidów zapobiega uszkodzeniu nerwów, zmniejsza częstość oraz nasilenie inwalidztwa i zniekształceń. Stosowanie klofazyminy w łagodnych reakcjach jest kontrowersyjne, ale w wielu przypadkach pozwala na zmniejszenie dawki kortykosteroidów. Natomiast talidomid nie jest skuteczny w leczeniu tej postaci trądu. Objawowe leczenie reakcji typu II jest zawsze konieczne. Jednocześnie należy kontrolować, czy nie powstały zmiany narządowe. Talidomid jest skuteczny w większości przypadków i jest uważany za lek z wyboru dla mężczyzn oraz dla kobiet, które zostały chirurgicznie ubezpłodnione lub są w wieku postmenopauzalnym. Z uwagi na działania teratogenne talidomidu nie można podawać kobietomw w wieku rozrodczym, poza wyjątkowymi przypadkami. Dawka leku może znacznie różnić się w poszczególnych przypadkach, ale najczęściej początkowo podawane jest 100 mg 2 x dziennie i w ciagu 3-5 dni może być zmniejszona. Dawka stosowana w terapii przewlekłej jest ustalana w zależności od wpływu na procesy zapaleń. Jeżeli talidomid jest nieosiągalny, może być stosowany również prednizon, szczególnie w przypadkach, w których doszło do zapalenia nerwów, według schematów zalecanych w odczynach łagodnych. Alternatywnie można podawać klofazyminę, ponieważ lek ten wykazuje właściwości przeciwbakteryjne i przeciwzapalne.

    Streszczenie angielskie: The treatment of reversal mild reaction only require symptomatic treatment with analgesics, but in severe reaction the drug of choice is oral prednisone or prednisolone. The initial dose is 1 mg/kg/day (60-80 mg), and it should be continued at least for a week. The steroid treatment prevent further nerve damage and decrease the frequency and severity of disabilities and deformities as compared with shorter courses of the drugs. The use of clofazimine in reversal reaction is controversial, but in some cases it can have a steroid sparing effect. Thalidomide has no beneficial effect on reversal reactions. The symptomatic treatment of the type II reaction is required as well as evaluation for other precipitant conditions. Thalidomide is effective for most cases and it is considered the drug of first choice in men, and also for women who are surgically sterilized or postmenopausal. Because of its teratogenicity it cannot be given to women of childbearing potenital except under special situations. The dose of thalidomide varies widely between patients, usually the initial dose is 100 mg twice a day, within 3 to 5 days the dose can be reduced, the permanent dose have to be adjusted to control the reaction. If this drug is not available prednisone could be also used, especially if there is any evidence of neuritis, as indicated in reversal reactions. Another option is clofazimine, because this drug has antibacerial and anti-reaction effect.


    2244/2523

    Tytuł oryginału: Psoriatic epidermis expresses high levels of Interleukin 18 (IL-18), IL-18 receptor mRNA and IL-18 protein.
    Tytuł polski: Naskórek łuszczycowy wykazuje wysoką ekspresję mRNA dla interleukiny 18 (IL-18), receptora IL-18, jak i samej proteiny IL-18.
    Autorzy: McKenzie Roddie C., Boyce Filicity, Szepietowski Jacek C., Forsey Rosalyn J., Howie Sarah E. M., Hunter John A. A., Gracie J. Alastair
    Źródło: Dermatol. Klin. 2002: 4 (1/4) s.17-23, il., bibliogr. 24 poz., streszcz. - Doroczne Spotkanie Brytyjskiego Towarzystwa Dermatologicznego GB 04. 2000
    Sygnatura GBL: 313,522

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie: Łuszczyca jest przewlekłą zapalną chorobą skóry charakteryzującą się przyspieszoną proliferacją i zaburzonym różnicowaniem się keratynocytów oraz naciekiem naskórka/skóry, składającym się z limfocytów T i neutrofili. Nadal nie w pełni jasne pozostaje, czy naciekające komórki T mają fenotyp TH-1 czy TH-2. Interleukina 18 (IL-18) jest produkowana przez aktywowane makrofagi i stymuluje produkcję interferonu ç przez komórki T. Receptor IL-18 (IL-18R) uznawany jest powszechnie za marker odpowiedzi typu TH-1. Cel pracy: Ponieważ ogniska łuszczycowe zawierają duże ilości interferonu ç, w pracy postanowiono zbadać ekspresję: mRNA dla IL-18, mRNA dla IL-18R oraz proteiny IL-18, aby wyjaśnić czy łuszczyca jest chorobą o odpowiedzi typu TH-1. Metody: Reakcja odwrotnej transkrypcji - łańcuchowej polimerazy (RT-PCR) została wykorzystana do oceny ekspresji mRNA dla IL-18 i dla IL-18R. Proteina IL-18 została uwidoczniona metodą immunohistochemiczną. Wyniki: Ekspresja IL-18 mRNA w skórze zmienionej chorobowo u pacjentów z łuszczycą (n = 24) okazała się 2,7-krotnie większa w porównaniu do tej w skórze osób zdrowych (p = 0,04, n = 9) oraz w skórze niezmienionej chorych na łuszczycę (p = 0,004, n = 14). Nie stwierdzono istotnych różnic w ekspresji badanego parametru w skórze osób zdrowych i skórze nie zmienionej chorych na łuszczycę. Ekspresja IL-18R mRNA była również istotnie wyższa w ogniskach łuszczycowych niż w skórze osób zdrowych (p = 0,01) czy w skórze ...

    Streszczenie angielskie: Background: Psoriasis is a chronic hyperproliferative skin disorder characterised by keratinocyte (KC) hyperproliferation, abnormal differentiation and infiltration of the epidermis/dermis by inflammatory cells including T-cells and neutrophils. Debate has continued whether the infiltrating T-cells are of te TH-1 or TH-2 helper phenotype. The TH-1 cytokine interleukin 18 (IL-18) is produced by activated macrophages and stimulates interferon ç production by T-cells. The IL-18 receptor (IL-18R) has been claimed to be the definitive TH-1 marker, as it is lost from TH-2 helper CD4+T-cells. Objectives: Since psoriatic plaque contains much interferon gamma, we examined the expression of: IL-18 mRNA, IL-18 receptor mRNA and IL-18 protein to clarify the quesiton of whether psoriasis is a TH-1 T-cell mediated disease. Methods: The abundance of mRNA for IL-18 and IL-18R was assayed by reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemistry was used to visualise IL-18 protein. Results: Singificant levels of IL-18 mRNA were found in normal skin but were 2.7 - fold higher in lesional psoriatic skin(n = 25) compared with normal (p = 0.04, n = 9) and non-lesional psoriatic skin (p = 0.004, n = 14). Non-lesional and normal skin were not significantly different. Levels of the IL-18 receptor mRNA were also significantly raised in lesional skin compared to normal (p = 0.01, n = 14) and non-lesional skin (p = 0.001). Il-18 protein was strongly expressed throughout ...


    2245/2523

    Tytuł oryginału: Poly(HEMA) - based embolic material in endovascular surgery of liver.
    Tytuł polski: Poly(HEMA) - materiał do embolizacji w chirurgii wewnątrznaczyniowej wątroby.
    Autorzy: Hor…k Daniel, Sitnikov Alexander, Guseniov Eldar, Kokov Leonid, Titova Mariya, Adamyan Arnold, Gumargalieva Klara
    Źródło: Polimery Med. 2002: 32 (3/4) s.48-62, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 305,609

    Hasła klasyfikacyjne GBL:
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie polskie: U pacjentów z ogniskowymi zmianami w wątrobie do zamknięcia światła gałęzi tętnicy wątrobowej, stosowano materiał poli-(2-hydroksyetylo-metakrylan) czyli poly(Hema). Materiał ten przebadano metodami fizykochemicznymi oraz biologicznymi, włączając w to badania hematologiczne i cytologiczne. W ocenie właściwości mechanicznych badanego materiału żelowego, pomocne były metody elastograficzne. Poly(Hema) okazał się materiałem stabilnym w zastosowaniach wewnątrznaczyniowych, nie wyakzał istotnej utraty elastyczności i utrzymywał konsystencję podobną do tkanek miękkich organizmu. Badania krwi w kontakcie z hydrożelowym materiałem poly(Hema) wykazały jego biolgiczną obojętność. Wewnątrznaczyniowej embolizacji z zastosowaniem poly(Hema) podano 315 pacjetnów z zmiejscowymi zmianami w wątrobie, takimi jak krwawienia lub też pierwotne lub matastyczne guzy. Procedura ta poprzedzała zazwyczaj postępowanie chirurgiczne. W porównaniu do bezpośrednich operacji w krwiopochodnych uszkodzeniach w wątrobie bez wstępnej wewnątrznaczyniowej embolizacji, embolizacja z zastosowaniem poly(Hema) pozwoliła na 2,5 do 3-krotne zmniejszenie krwawienia w strefie operacyjnej. Jednocześnie materiał embolizacyjny poly(Hema) indukował aktywację czynników krzepniecia w okresie po embolizacji.

    Streszczenie angielskie: Physico-chemical and medico-biological methods, including hematology and cytology, were used in an evaluation of properties of poly(2-hydroxyethyl methacrylate) (poly(HEMA))-based embolic material indicated in the occlusion of branches of hepatic artery of patients with focal alterations of the liver. The elastographic method helped in predicting mechanical properties of the hydrogel material. Poly(HEMA) was mechanically stable for endovascular applications, exhibited no significant loss in elasticity and possessed consistency resembling the soft tissue of the organism. Analysis of blood in contact with poly(HEMA) hydrogel provided a control of its biological intertness. Recently, 315 patients with focal alterations of the liver, including hemobilic hemorrhages and both primary and metastatic tumors, underwent endovascular occlusion with poly(HEMA) emboli as a pre-srugical step or as a simple occlusive measure. Compared with a direct operation on hemangiomatous injuries in the liver without endoascular occlusion, embolization with poly(HEMA) allowed to reduce 2.5 - 3 times bleeding in the operational zone. At the same time, the poly(HEMA) embolic material induced activation of general hemostatic reaction in the postembolization period.


    2246/2523

    Tytuł oryginału: Effect of reactive oxygen species (ROS) on human sperm cells: the role of magnesium and zinc content of seminal plasma.
    Tytuł polski: Wpływ reaktywnych form tlenu (ROS) na komórki spermy ludzkiej: rola zawartości magnezu i cynku w plazmie nasienia.
    Autorzy: Kiss Sandor A., Zavaczki Zoltan, Sz”ll”si Janos, Koloszar Sandor, Csikkel-Szolnoki Anna
    Źródło: J. Elem. 2002: 7 (2) s.115-122, il., tab., bibliogr. s. 120-121, streszcz.
    Sygnatura GBL: 313,195

    Hasła klasyfikacyjne GBL:
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie polskie: Skuteczne zapłodnienie komórki jajowej zależy od obecności licznych, ruchliwych oraz nieuszkodzonych pod względem budowy i funkcji plemników w ejakulacie. Pomiędzy liczebnością plemników w spermie a zawartością magnezu w plazmie nasienia istnieje pozytywna korelacja. Zarówno piśmiennictwo jak i nasze dane pozwalają wnioskować, iż poziom Mg i Zn ma wpływ na skuteczność zapłodnienia przez komórki spermy. Najlepsze cechy spermy stwierdzono przy poziomach Mg i Zn odpowiednio 4 i 6 nM1-1, oraz w stosunku molarnym 1 : 2. Doświadczenia na ludziach i zwierzętach dowodzą, iż Mg ma korzystny wpływ na płodność męską. Ponieważ wolne rodniki powodują uszkodzenia komórek spermy, między ROS (reaktywnymi formami tlenu) a ruchliwością plemników zachodzi ujemna korelacja. Korelacja między ruchliwością plemników a zawartością Mg w ejakulacie ma kształt krzywej w kształcie dzwonu; korelacja między LPO (tworzenie grup nadtlenkowych lipidów) oraz ROS a poziomem Mg przybiera kształt ujemnej krzywej w kształcie dzwonu. Ponadto stwierdziliśmy, że poziom Mg w ejakulacie (0,7/1,0 nM.1-1) jest od trzech do dziesięciu razy wyższy niż w surowicy krwi.

    Streszczenie angielskie: The success of oocyte fertilisation highly depends on presence of high number of motile, structurally and functionally intract sperm cells in the ejaculate. There is positive correlation between sperm concentration and magnesium content of seminal plasma. According to the literature and our data we can conclude that both Mg and Zn have effect of fertility of sperm cells. The best sperm characteristics were found when the Mg and Zn level were 4/6 nM.1-1, respectively and the Mg:Zn molar ratio is 1:2. Human and animal experiments demonstrate the favourable effect of Mg on male fertility. Since free radicals damage sperm cells, there is an inverse correlation between ROS and sperm motility. Correlation between motility and Mg content of ejaculate shows a bell-shaped curve, the correlation between LPO (Lipid peroxidation) or ROS (Reactive oxygen species) and Mg level show an inverse bell-shaped curve. We also concluded that Mg level of ejaculate (0,7/1,0 nM.1-1) is 3-10 fold higher than in blood serum.


    2247/2523

    Tytuł oryginału: Integration of group dynamic principles in the dynamic psychiatric treatment.
    Autorzy: Ammon Maria
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (3) s.5-14, bibliogr. 34 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In this article the author describes the group dynamic principle as an integrational part of dynamic psychiatry. The integration of the group dynamic principle into the therapeutic approach of Dynamic Psychiatry had a great influence for thr treatment of "early disturbed" patients like borderline and personality disorders or schizophrenic patients. Before describing the therapeutic method of the dynamic psychiatry a short over view of the historical development of group-therapeutic approaches will be given. Finally the author refers to the indication of patients who have the predisposition for being treated with group-psychotherapy and the importance of integrating group-dynamic principles in inpatient treatment.


    2248/2523

    Tytuł oryginału: Cognitive functions in remitted unipolar female depressive patients during maintenance treatment with antidepressants.
    Autorzy: Jaracz J[an], Borkowska A., Chłopocka-Woźniak M., Rybakowski J. K.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (3) s.15-23, tab., bibliogr. 53 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Aim: Several studies have shown that depression is associated with cognitive deficits, however, it is not clear if cognitive impairment persists upon recovery. The authors' goal was to examine a neuropsychological performance in, unipolar depressive female patients during remission. Methods: The Wisconsin Card Sorting Test (WCST), the Verbal Fluency Test (VFT) and the Giessen Maze Test were administered to 21 remitted female patients and matched 17 control subjects. Al patients had been for at least 6 months on maintenance treatment with antidepressants before the study. Results: Patients achieved worse results than the control group on the Giessen Maze Test. No differences between both groups in WCST and VFT were noticed. Conclusions: These results point to deficits of visuospatical cognitive functions mostly related to the right hemisphere in unipolar patients which persisted despite of long-term remission.


    2249/2523

    Tytuł oryginału: Gender-related prognostic factors in first admission DSM-III schizophrenic patients.
    Autorzy: Kalisz Aneta, Cechnicki Andrzej
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (3) s.25-36, il., tab., bibliogr. 23 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The paper presents gender-related prognostic factors in first admission DSM-III schizophrenic patients. The evaluation was made during their first admission.


    2250/2523

    Tytuł oryginału: Correlation between some features of social networks and treatment autcomes of schizophrenic patients three years after the first admission. A follow-up study.
    Autorzy: Wojciechowska Anna, Cechnicki Andrzej, Walczewski Krzysztof
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (3) s.37-46, tab., bibliogr. 13 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Significant correlation was found between certain features of social networks of schizophrenic patients three years after the first admission (size, age, number of persons involved, duration of relationship in the network, type of support system. amount and localisation of support), 'specific of treatment' (insight, satisfaction with treatment, compliance, motivation for treatment), and outcome of treatment at the psychopathological and social level.


    2251/2523

    Tytuł oryginału: Detection of anti-Borna Disease Virus antibodies in patients hospitalized in psychiatric hospitals situated in the mid-western region of Poland.
    Autorzy: Rybakowski Filip, Yamaguchi Kazunari, Krzymiński Stefan, Zmyślony Franciszek, Biernat Jerzy, Kociałkowski Marek, Tandeck Andrzej, Trafarska Barbara, Zalejski Marian, Sawada Takashi, Naraki Tohru, Czerski Piotr, Rajewski Andrzej, Rybakowski Janusz K.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (3) s.47-54, tab., bibliogr. 38 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • mikrobiologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The seroprevalence of anti-Borna Disease Virus antibodies in the population of patients hospitalised in psychiatric hospitals of mid-western Poland was assessed with the ACLIA methos.


    2252/2523

    Tytuł oryginału: An unfinished didactic novel. Chapter 3: Berlin.
    Autorzy: Chessick Richard D.
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (3) s.55-72, bibliogr. s. 70-72
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie


    2253/2523

    Tytuł oryginału: Is there a role for sodium iodide symporter autoimmunity in the etiology of Addison's disease?
    Tytuł polski: Czy symporter sodowo-jodowy odgrywa rolę w etiologii choroby Addisona?
    Autorzy: Czarnocka Barbara, Kasperlik-Załuska Anna A., Pastuszka Danuta
    Źródło: Endokrynol. Pol. 2002: 53 (4) s.525-532, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Od momentu sklonowania ludzkiego symportera sodowo-jodowego (hNIS) szereg badań sugerowało jego rolę jako nowego autoantygenu w chorobach tarczycy z autoagresji. Autoimmunologiczne choroby tarczycy są jednymi z najczęściej występujących u pacjentów z idiopatyczną chorobą Addisona. Humoralna odpowiedź manifestuje się występowaniem u pacjentów przeciwciał tarczycowych, głównie skierowanych przeciwko peroksydazie tarczycowej. W prezentowanej pracy, badano czy hNIS jest związany z procesami autoimmunizacyjnymi w chorobie Addisona. Badano, czy w surowicach 45 pacjentów i 20 zdrowych są obecne przeciwciała skierowane przeciwko hNIS. Jako antygeny w metodzie ELISA stosowano syntetyczne peptydy odpowiadające zewnątrzkomórkowej części białka i białko NIS zawarte w błonach komórek COS 7 transfekowanych plazmidem zawierającym cDNA hNIS. Używając w badaniach surowice oraz oczyszczone immunoglobuliny G (IgG) nie stwierdzono w badanych surowicach przeciwciał skierowanych przeciwko ludzkiemu NIS. Wyniki sugerują, w chorobie Addisona, występują bardzo rzadko.

    Streszczenie angielskie: Several studies suggest a possible role of the sodium iodide symporter (NIS) as a new autoantigen in thyroid autoimmunity. Thyroid autoimmune disorders occur with a high prevalence in patients with idiopathic Addison's disease. The aim of the present study was to evaluate the role of NIS as a potential antigen implicated in the autoimmunological processes involved in the etiology of idiopathic Addison's disease. Forty-five (45) serum samples, taken from patients with idiopathic Addison's disease and 20 from normal subjects, were assayed for the presence of autoantibodies to human NIS. For anti-NIS antibodies detection the ELISA system was employed, using - as antigen - synthetic peptides, corresponding to the extracellular portion of hNIS or hNIS protein expressed in COS-7 cells. Using both, whole sera and extracted IgGs, we did not detect the presence of antibodies against hNIS protein. Our study suggests that, in sera of patients with idiopathic Addison's disease, antibodies that recognize Na+/I- symporter are either very rare or not present (at least in our series) in contrary to the antibodies against TPO.


    2254/2523

    Tytuł oryginału: Utility of plasma metanephrines in the diagnosis of adrenal incidentalomas.
    Tytuł polski: Znaczenie oznaczania poziomów metanefryn w osoczu w rozpoznaniu guza nadnerczy typu incidentaloma.
    Autorzy: Kasperlik-Załuska Anna A., Rosłonowska Elżbieta, Bornstein Stefan R., Pacak Karel, B”ttner Antje, Eisenhofer Graeme
    Źródło: Endokrynol. Pol. 2002: 53 (4) s.549-556, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 304,167

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Wszyscy pacjenci z wykrytymi przez przypadek guzami nadnerczy powinni zostać skierowani na badania, mające na celu określenie czy nie są to zmiany złośliwe oraz czy nie występuje nadmierne wydzielanie hormonów. W wyniku tych badań dokonuje się wyboru przypadków, wymagających postępowania chirurgicznego. Ponieważ guz chromochłonny stanowi zagrożenie życia, w przypadkach wykrycia guzów nadnerczy typu incydentaloma, należy zastosować procedury badań przesiewowych, mających na celu identyfikację lub wykluczenie obecności guzów chromochłonnych. Oznaczanie poziomu metanefryn w osoczu jest bardziej czułą metodą niż oznaczanie poziomów katecholamin w moczu i w osoczu oraz - być może - od oznaczania poziomów metanefryn w moczu. Oznaczaliśmy poziomy wolnej i całkowitej normetanefryny i metanefryny, jak również noradrenaliny i adrenaliny w grupie 54 nie wybieranych specjalnie pacjentów z wykrytymi guzami typu incidentaloma, kierowanymi do Klinik Endokrynologii CMKP w Warszawie w okresie między 15 września 1998 i 15 marca 1999. Guz chromochłonny wykryto jedynie u jednego pacjenta - w oparciu o badania biochemiczne i analizy mikroskopowe. U niektórych spośród pozostałych pacjentów zaobserwowano umiarkowanie podwyższone poziomy normetanefryny, stąd zostali oni objeci dalszą obserwacją. Wyniki naszych badań sugerują, że oznaczanie stężeń metanefryn w osoczu może być użyteczną metodą w rozpoznawaniu guzów chromochłonnych u pacjentów z wykrytymi wcześniej guzami nadnerczy typu incidentaloma.

    Streszczenie angielskie: All patients with incidentally found adrenal tumours should be investigated for malignancy and for hormonal hypersecretion to select the cases that require surgical treatment. Since pheochromocytoma is a life-threatening tumour a screening procedure to identify or to exclude such tumours has to be applied in adrenal incidentalomas. Determination of plasma metanephrines is more sensitive than measurement of urinary metanephrines. We determined plasma free and total normetanephrine and metanephrine as well as noradrenaline and adrenaline levels in a group of 54 non-selected patients with adrenal incidentalomas referred to the Department of Endocrinology, Warsaw, between 15 September 1998 and 15 March 1999. Pheochromocytoma was diagnosed in only one patient based on biochemical nad microscopic studies. In some other patients moderately elevated plasma levels of normetanephrine or metanephrine were found and therefore further observation is proposed. In the remaining patients normal concentrations of plasma metanephrines and catecholamines or non-specific changes excluded pheochromocytoma. Our study suggests that measurements of plasma concentrations of metanephrines may be an useful method for diagnosis of pheochromocytoma among patients with adrenal incidentalomas.


    2255/2523

    Tytuł oryginału: Laminar distribution of the pathological changes in the cerebral cortex in variant Creutzfeldt-Jakob disease (vCJD).
    Autorzy: Armstrong Richard A., Cairns Nigel J., Ironside James W., Lantos Peter L.
    Źródło: Folia Neuropathol. 2002: 40 (4) s.165-171, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: To determine the pattern of cortical degeneration in cases of variant Creutzfeldt-Jakob disease (vCJD), the laminar distribution of the vacuolation ("spongiform change"), surviving neurones, glial cell nuclei, and prion protein (PrP) deposits was studied in the frontal, pariertal and temporal lobess. The vacuolation exhibited two common patterns of distribution: either the vacuoles were present throughout the cortex or a bimodal distribution was present with peaks of density in the upper and lower cortical laminae. The distribution of the surviving neurones was highly variable in different reggions; the commonest pattern being a uniform distribution with cortical depth. Glial cell nuclei were distributed largely in the lower cortical laminaee. The non-florid PrP deposits exhibited either a bimodal distribution or exhibited a peak of density in the upper cortex while the florid deposits were either uniformly distributed down the cortex or were present in the upper cortical laminae. In a significant proportion of areas, the density of the vacuoles was positively correlated with either the surviving neurones or with the glial cell nuclei. These results suggest similarities and differences in the laminar distributions of the pathogenic changes in vCJD compared with cases of sporadic CJD (sCJD). The laminar distribution of vacuoles was more extensive in vCJD than in sCJD whereas the distribution of the glial cell nuclei was similar in the two disorders, PrP deposits in sCJD were localised mainly in the lower cortical laminaee while in vCJD, PrP deposits were either...


    2256/2523

    Tytuł oryginału: Interleukin 12 and interleukin 10 are affected differentially by treatment of multiple sclerosis with glatiramer acetate (Copaxone).
    Autorzy: Losy Jacek, Michałowska-Wender Grażyna, Wender Mieczysław
    Źródło: Folia Neuropathol. 2002: 40 (4) s.173-175, tab., bibliogr. 20 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Proinflammatory cytokines produced by Th-1 cells and cytokines with immunosupressive properties play an important role in the pathogenesis of multiple sclerosis (MS). Glatiramer acetate (GA) is one of the most important immunomodulatory agents used in the therapy of MS. The mechanism of action of GA in MS is not yet fully explained. In our previous study we found the significant down-regulation of interleukin 18 (IL-18), a proinflammatory cytokine inducing the production of interferon ç during therapy wiht GA in MS patients. The purpose of this study was to evaluate the effect of GA in a dose 20 mg daily in a period of 6 months on interleukins IL-10 and IL-12. Thirty-one patients with definite MS and 30 control subjects were the subject or our study. The interleukins levels in sera were measured by the ELISA test. A significant increase was found of IL-12 and also of IL-10 levels in MS patients in comparison with control group. We also established a significant decrease of IL-12 after 3 and 6 months of GA therapy and some insignificant differences in the level of IL-10 (the decrease after 3 months and the increase after 6 months). IL-12 is proinflammatory cytokine secreted by blood mononuclear cells, including dendritic cells in response to antigens and mitogens and is thought to contribute to the pathogenesiss of MS. Therefore the established downregulation of IL-12 as well as that previously described of IL-18 suggest a marked relationship between the clinical effect and downregulatory action of GA on proinflammatory interleukins. The insignificantt change of IL-10...


    2257/2523

    Tytuł oryginału: Proinflammatory cytokines in injured rat brain following perinatal asphyxia.
    Autorzy: Maślińska Danuta, Laure-Kamionowska Milena, Kaliszek Agnieszka, Makarewicz Dorota
    Źródło: Folia Neuropathol. 2002: 40 (4) s.177-182, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In contrast to astrogliosis, which is common to injuries of the adult CNS, in the developing brain this process is minimal. Reasons postulated for this include the relative immaturity of the immune system and the consequent insufficient production of cytokines to evoke astrogliosis. To explore this hypothesis, the study was undertaken to detect the presence of some proinflammatory cytokines in the injured rat brain following perinatal asphyxia (ischaemia/hypoxia). The localisation of TNF-ŕ, IL-15, IL-17 and IL-17 recpetors was visualised by means of immunohistochemistry. In numerous neurones of the rat brain, the IL-17 appeared to be constitutively expressed. In the early period of inflammation the IL-15 was produced mainly by the blood cells penetrating the injured brain but later it was synthesised also by reactive astrocytes surroundding brain cysts and forming dense astrogliosiss around necrotic brain regions. The direct effect on astrogliosis of other estimated cytokines seems to be negligible. All the results lead to the conclusion that from all cytokines identified in the injured immature rat brain the IL-15 plays the most important role during inflammatory response and participates in the gliosis of reactive astrocytes.


    2258/2523

    Tytuł oryginału: Discrete glioneuronal malformative lesions in the foetal and infantile cerebral cortex.
    Autorzy: Laure-Kamionowska Milena, Maślińska Danuta, Raczkowska Barbara
    Źródło: Folia Neuropathol. 2002: 40 (4) s.183-191, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: Microdysginesis is a term describing microscopic cortical cytoarchitectural abnormalities. Histologically this change shows an irregular glioneuronal tissue combination forming an abnormal structure of the cortex. The pathological features of this malformation are subtle and less well defined than other more distinctive cortical malformations. The clinical significance of these discrete glioneuronal malformations is controversial. Microscopic dysgenetic changes have been reported in cases with intractablee epilepsy but similar changes may be seen in neurologically normal adults. The purpose of our study was the investigation of microdysgenetic lesions in the developing nervous system with regard to normal migration, differentiation and maturation. The post-mortem routine investigated foetal and infantile brains were analysed histologically for the presence of discrete cortical malformations. A wide spectrum of cytoarchitectural glioneuronal malformations was found in the invetigated material. We observed leptomeningeal glioneuronal heterotopias, subpial bands of heterotopic neurones, nests of ectopic neurones in the first cortical layers, neuronal and glial clusters, small foci with irregularity of laminar structure of the cortex. Microdysgenetic changes arose from an insult occurring in the later stages of cortical development and influencing the normal fate of neuroglial cells. Various types of focal morphological and cytoarchitectonial developmental abnormalities have been associated with behavioural and neuropsychological deficits in older infants.


    2259/2523

    Tytuł oryginału: Changes in the distribution of sugar receptors in blood vessels and cell elements of rat brain caused by photochemically induced focal ischaemia.
    Autorzy: Szumańska Grażyna, Gadamski Roman, Victorov Ilja V., Barskov Igor V., Wojda Renata, Krzywicka Jolanta
    Źródło: Folia Neuropathol. 2002: 40 (4) s.193-202, il., bibliogr. 30 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • in vitro

    Streszczenie angielskie: The lectin technique was applied to the histochemical studies of glycoconjugates comprising membranes of capillary endothelial cells and other cellular elements of the CNS. In the studies we used the following lectins: Concanavalian A (Con A), Bandeirea simplicifolia agglutinin (BS-I), Helix pomatia agglutinin (HPA), Ricinus communis agglutinin (RCA-120), Wheat germ agglutinin (WGA). We noticed changes in the localisation of the glycoconjugates, which are the results of cerebral ischaemia caused by focal irradiation of the left hemisphere of the brain after the previous intravenous injection of control animals with Rose bengal. The described changes seem to be the result of disturbances of the functioning of the blood-brain barrier, which was previously described (Gadamski et al. 2001). In this study, however, we have shown morphological and histochemical changes, which lead to the translocation of examined glycoconjugates within the appearing necrosis areas, arround them and in the regions significantly distant from them. This refers to neurones, glial cells and endothelia of brain vessels. So we have described a clear diminution of Con A and HPA-positive recpetors from neocortical and hippocampal neurones. The Con A receptors appeared however in morphologically changedd, contracted capillaries and HPA receptors in macrophages and reactive cells of necrosis areas. In these areas the BSI-I receptors also appeared and additionally labelled astrocytes in the hippocampuss and oligodendrocytes in the corpus callosum. The endothelial glycoconjugates visualised by RCA-120...


    2260/2523

    Tytuł oryginału: Lead stimulates the glutathione system in selective regions of rat brain.
    Autorzy: Strużyńska Lidia, Sułkowski Grzegorz, Lenkiewicz Aleksandra, Rafałowska Urszula
    Źródło: Folia Neuropathol. 2002: 40 (4) s.203-209, il., bibliogr. 44 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Lead (Pb) is a highly neurotoxic agent that causes functional and structural abnormalities in the brain. Glutathione (GSH) is a main molecule involved in the protection mechanisms against Pb itself and against reactive oxygen species generated by the metal. This study was carried out to investigate the effect of Pb on the glutathione system in several regions of adult rat brain. In the model of Pb toxicity, adult Wistar rats were exposed to 25 mg of lead acetate/kg b.w. for 3 days. Glutathione and the related enzymes i.e. ç-glutamylcysteine synthetase (ç-GCS), glutathione reductase (GR) and glutathione S-transferases (GSTs) were examined in the hippocampus, cerebellum and forebrain. In the cystolic fraction the concentration of total GSH and the activity of GR increased only in the cerebellum of Pb-exposed rats. Higher increases of both parameters were observed in mitochondrial fraction obtained from the cerebellum and hippocampus. The activity of cystolic enzyme - ç-GCS was enhanced only in the forebrain. Regarding cytosolic GSTs, changes in the activity together with enhanced relative density of enzyme protein were found in the cerebellum and hippocampus. Generally, activation of the glutathione system observed shortly after Pb treatment suggests the protective response of the brain in toxic insult. Regional differences in the pattern of these changes may coincide with different susceptibility to Pb. Present results suggest also that mitochondrial mechanisms might account for lead toxicity.


    2261/2523

    Tytuł oryginału: Experimental and human ischaemia: is the penumbra present in human ischaemic stroke?
    Autorzy: Rafałowska Janina
    Źródło: Folia Neuropathol. 2002: 40 (4) s.211-217, il., bibliogr. 60 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Experimental occlusion of the middle cerebral artery and reduction of cerebral blood flow (CBF) below 15 ml/100 gm/per minute cause failure of the somatosensory evoked response and lethargy of cortical neurones. Increase of CBF to normal value normalises the bioelectrical activity within the "penumbra"- the zone surrounding the necrotic area. In this "risk zone" neurones can survive only a few hours. So the penumbra is a "therapeutic window" in which therapy can save some neurones from death. However, if decrease of CBF is continued, numerous cells within the penumbra gradually die. The phenomenon of the penumbra, based on experiments, was applied to human ischaemic stroke; however great differences between experimental and human brain ischaemia do exist. The human course of disease and the size of necrotic lesions depend on numerous additional factors. The three very important critical values of CBF which decrease in human brain ischaemia are difficult to examine. New imaging methods play a great diagnostic role in searching for the penumbra, but their diagnostic possibilities and results are limited. In the short-time duration of the therapeutic window both CT and MRI often do not indicate ischaemic lesion. So, it is known whether the penumbra is present or not. Conclusive estimation of MRI diffusion-weighted imaging and perfusion-imaging and of their coefficient is impossible to obtain in the timee exceeding the "therapeutic window". Numerous additional various diseases and compensatory vascular mechanisms influence the necrotic zone in human focal ischaemia...


    2262/2523

    Tytuł oryginału: Familial incidence of obstructive hydrocephalus due to posterior fossa tumours leading to the diagnosis of von Hippel-Lindau disease - a case report.
    Autorzy: Bogucki Jacek, Taraszewska Anna, Baraniecka Jolanta, Czernicki Zbigniew
    Źródło: Folia Neuropathol. 2002: 40 (4) s.219-222, il., bibliogr. 15 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia
  • neurologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Von Hippel-Lindau disease (VHLD) is an autosomal dominant disorder predisposing to the development of different histological types of tumours with predominance of CNS haemangioblastomas in the majority of cases. We present a case of 35-year old man with obstructive hydrocephalus due to multiple posterior fossa tumours. Famililal history revealed two relatives operated on previously because of a posterior fossa tumour (in one case haemangioblastoma was diagnosed). During surgery two cerebral tumours were removed radically via the suboccipital approach. On a histopathological examination the typical features of heamangioblastoma were found in both tumours composed of stromal cells and a dense network of vessels, mostly capillaries. The presence of neoplastic infiltration with angiogenesis in the surrounding cerebellar tissue was evidenced in the presented case. Based on the clinical and histopathological data VHLD was diagnosed. Genetic analysis confirmed the presence of the non Hippel-Lindau gene mutation. The case presented suggests that genetic disregulation in VHLD may be responsible for a more aggressive behaviour of VHLD-related haemangioblastomas in comparison with sporadic disease.


    2263/2523

    Tytuł oryginału: Abstracts from XII Conference of Association of Polish Neuropathologists, Warsaw, May 20-22, 2002.
    Źródło: Folia Neuropathol. 2002: 40 (4) s.223-250, tab. - 12 Konferencja Polskiego Towarzystwa Neuropatologów Warszawa 20-22.05. 2002
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny


    2264/2523

    Tytuł oryginału: Diagnostics of latent magnesium deficiency in human organism using modified magnesium loading test.
    Tytuł polski: Rozpoznanie utajonego niedoboru magnezu z zastosowaniem zmodyfikowanych testów obciążenia magnezem.
    Autorzy: Rudziński Janusz, Walasek Lech, Jurga Małgorzata
    Źródło: J. Elem. 2002: 7 (1) s.35-47, tab., bibliogr. s. 45, streszcz.
    Sygnatura GBL: 313,195

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Niedobór magnezu jest najczęstszym niezdiagnozowanym zaburzeniem elektrolitowym w ustroju i odgrywa istotną rolę w patogenezie wielu schorzeń. Trudności diagnostyczne są wynikiem braku prostych i wiarygodnych metod oceny. Uznaną metodą oceniającą gospodarkę magnezem jest tzw. dożylny test obciążenia magnezem polegający na podaniu 30 mmol MgSO4 w infuzji dożylnej trwającej nie mniej niż 8 godzin i oznaczaniu ilości wydalonego magnezu w moczu dobowym. Modyfikacje testu obciążenia magnezem polegały na zmniejszeniu dawki obciążenia magnezem i skróceniu czasu infuzji w stosunku do standardowego (referencyjengo) testu obciążenia. Badania wykonano u 134 chorych (74 mężczyzn i 60 kobiet) w wieku 20-71 lat, średnio 43,4 lat. Badano następujące modyfikacje testu obciążenia magnezem: 1. 30 mmol MgSO4 podawane w 500 ml 5 proc. glukozy przez 8 godzin 2. 15 mmol MgSO4 podawane w 500 ml 5 proc. glukozy przez 8 godzin 3. 30 mmol MgSO4 podawane w 500 ml 5 proc. glukozy przez 4 godziny 4. 15 mmol MgSO4 podawane w 500 ml 5 proc. glukozy przez 4 godziny. Dla oceny wyników uzyskanych w testach zmodyfikowanych, po dwóch dniach u każdego badanego wykonywano standardowy test obciążenia magnezem. Zmniejszenie dawki magnezu do 15 mmol podawanej w infuzji do 4 godzin dało wyniki porównywalne do standardowego testu obciążenia magnezem (30 mmol MgSO4 przez 8 godzin). Natomiast skrócenie czasu infuzji do 4 godzin przy zachowaniu dawki 30 mmol magnezu daje wyniki znacznie zaniżone i ...

    Streszczenie angielskie: The magnesium deficiency is the most often not diagnosed electrolytic disorder in the organism and significant in the pathogenesis of several ailments. Difficulties in diagnostics are due to lack of easy and reliable methods. The reliable method accessing Mg deficiency is intravenous magnesium loading test consisting in intravenous infusion of 30 mmol MgSO4 lasting not less than 8 hours and denotation of Mg elimination in daily urine. Modifications of the mg loading test have consisted in lessening of Mg dose and shortening time of infusion in comparison with the standard loading test. Investigations have been performed on 134 patients (74 men, 60 women) aged between 20 and 71 (on average, 43.4 years of age). The following types of modification of the Mg loading test have been investigated: 1. 30 mmol MgSO4 in 500 ml 5 p.c. glucose by 8 hours 2. 15 mmol MgSo4 in 500 ml 5 p.c. glucose by 8 hours 3. 30 mmol MgSo4 in 500 ml 5 p.c. glucose by 4 hours 4. 15 mmol MgSo4 in 500 ml 5 p.c. glucose by 8 hours. Two day later, each patient had the stadard Mg loading test (30 mmol MgSO4 by 8 hours) performed in order to compare and estimate results obtained in the modified test. By lowering the Mg dose to 15 mmol administered in intravenous infusion over 8 hours or by lowering it to 15 mmol and shortening infusion to 4 hours, it was possible to obtain the resutls comparable with the standard Mg loading test (30 mmol MgSO4 by 8 hours). In contrast, the results obtained when the ...


    2265/2523

    Tytuł oryginału: Comparison of calcium, magnesium, potassium and sodium contents of Ginko biloba L. leaves from Hungary.
    Tytuł polski: Porównanie zawartości wapnia, magnezu, potasu i sodu w liściach Ginko biloba L. pochodzących z Węgier.
    Autorzy: Stefanovits-Banyai E., Bert‚nyi-Divinyi Zs., Kiss A. S., Blazovics A., Koczka N.
    Źródło: J. Elem. 2002: 7 (1) s.49-56, il., bibliogr. s. 55, sum.
    Sygnatura GBL: 313,195

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of our preliminary investigations was to determine the Caý+, Mgý+, Na+, K+ cation contents by ICP, cation rates and the magnesium coefficients (z) of ginkgo leaves (Ginkgo biloba L.). Our studies were carried out on ginkgo leaves collected from male and female trees at different times from two Botanical Gardens in Budapest and from Szeged in Hungary. Our results showed that the magnesium, calcium, sodium and potassium contents were always higher in the male samples than in female ones, ecxept one when the calcium content was lower in the male samples originated from Szeged. We have detected the highest ptoassium content in the Szeged samples because of salting for preventing icing in the town. We have found that the magnesium content of leaves was high and increased in the same way during the experimental time independently of the growing sites and the sexes of trees (in May about 3000 ćg/g and in September 5000-6000 ćg/g). The magnesium coefficients were increased from May to September, in May were around 0,08 and in September from 0,08 to 0,14. According to "z" coefficients the Ginkgo biloba trees are not a magnesium sensitive plants but we have fund more information about the plant using as therapeutic agent in modern pharmacology.


    2266/2523

    Tytuł oryginału: Markers of pulmonary diseases in exhaled breath condensate.
    Autorzy: Antczak Adam, Górski Paweł
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.317-323, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Exhaled breath condensate has been more and more extensively used as a novel and non-invasive method to study airway inflammation. It is simple to perform, very well tolerated by patients and no adverse events have been reproted so far. Serial measurements can be made with no harmful effects on patients, which is of extreme value in occupational medicine. Exhaed breath condensate has been obtained from both adult and children patients suffering from various pulmonary diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease, and interstitial lung diseases. Several markers and mediators are detectable in breath condensate: hydrogen peroxide, thiobarbituric acid-reactive substanes, isoprostanes, prostaglandins and leukotrienes. Nitric oxide-related markers ahve also been studied in teh condensate. There is increasing body of evidence that changes in condensate markers reflect local abnormalities of airway lining fluid.


    2267/2523

    Tytuł oryginału: Exposure to environmental tobacco smoke and children health.
    Autorzy: Tutka Piotr, Wielosz Marian, Zatoński Witold
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.325-335, bibliogr. 100 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • otorynolaryngologia
  • pediatria
  • toksykologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: This paper reviews the investigations of the effects of pre- and/or postnatal exposure to environmental tobacco smoke (ETS) on children health reported in the literature. The evidence from epidemiolgical studies demonstrate that children's exposure to ETS is a risk factor for a variety of diseases, including respiratory disorders and middle ear disease. However, the current research base on the ETS-associated risks is still inadequate to fully support strategies, programs and policy development in this are. For example, it is not definitively determined what methods should be used for assessing ETS exposure and predicting potential healht risks of exposed children. Based ont the available data, we tired to find out which methods seem to be most desirable for quanitfying ETS exposure in children. It is our opinion that among all biomarkers, teh measurements of blood, saliva or urinary cotinine and hair nicotine are, as for today, the most specific and sensitive methods for an objective assessment of ETS exposure in children. A combination of the measurement of body fluids cotinine and hair nicotine with the questionnaire and interview-derived information seems to be the optimal method for assessing ets exposure in children.


    2268/2523

    Tytuł oryginału: Occupational diseases in Poland, 2001.
    Autorzy: Pepłońska Beata, Szeszenia-Dąbrowska Neonila
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.337-345, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The Central Register of Occupational Diseases keeps the records of all reported and certified occupational diseases in Poland. In this paper the incidence of occupational diseases in Poland in 2001 is discussed on the basis of the data provided by the Register. The changes in the incidence pattern over the recent 30 years are also shown IN 2001, 6007 cases of occupational diseases were registered, with the incidence rate of 63.2 per 100 000 employees. The highest incidence rates were noted for seven categories of diseases: the vocal organ diseases, noise-induced hearing loss, pneumoconioses, contagious and invasive diseases, dermatoses, chronic diseases of bronchi, and vibration syndrome. Altogether these diseases covered 5239 cases (87.2 p.c. of all registered cases). Mining and quarrying, agriculture, hunting and forestry, education, health and social works were the economy activities with the highest incidence of occupational diseases. The majority of occupational diseases (93.9 p.c.) have developed after a long-term (over 10 years) exposure to particular harmful factors. As much as 58.5 p.c. of cases were recorded in males. The predominant occupaitonal diseases in males were occupational hearing lesions, while in females chronic vocal organ diseases, most common in teachers, were most frequently recognized. In Poland, the diseases of the vocal organ poses a serious problem from the medical and socio-economic points of view. These pathologies show the highest dynamics of the incidence among all registered occupational diseases. Over the last five years the vocal organ diseases have moved upwards to the top in the ranking, bot with respect to the number of cases and the incidence rate...


    2269/2523

    Tytuł oryginału: Viral hepatitis in health service workers in the province of Wielkopolska.
    Autorzy: Bilski Bartosz, Wysocki Jacek, Hemerling Marcin
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.347-352, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • gastroenterologia
  • choroby zakaźne

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Viral hepatitis is the most frequent occupational disease in the health service workers. On the ground of epidemiological data on certificaitons of occupational diseases, an analysis of morbidity of viral hepatitis was performed. Among viruses that can cause occupational hepatitis there are HAV, HBV and HCV. However, occupational HDV and HGV infections are also possible. In Poland, the number of hepatitis diagnosed as occupational diseases became more stable in the years 1996-1998, whereas morbidity of hepatitis C significantly increased. Such an epidemiological situation could be observed in the area of Wielkopolska and throughout the contry. In the former province of Poznań and in the present province of Wielkopolska, occupational hepatitis occurred mostly in nurses. In the nineteen sixties and seventies, the most dramatic increase in the incidence of hepatitis B was noticed in the population of nurses and midwives at the age between 21 and 30 years. This can provide evidence of especially high exposure to infectious factors in this occupational group and of high HBV infectivity. Nowadays, an average age at the time of diagnosis of hepatitis C is somewhat higher. Hepatitis C is usually recognized at the age between 30 and 39 years. A relatively low infectivity of HCV and mostly asymptomatic course of the infection, which delays diagnosis, may provide some explanations of these phenomena. The geographical distribution of stated cases of hepatitis C is difficult to predict and may suggest that some non-medical factors also play a role...


    2270/2523

    Tytuł oryginału: The validity of general health questionnaires, GHQ-12 and GHQ-28, in mental health studies of working people.
    Autorzy: Makowska Zofia, Merecz Dorota, Mościcka Agnieszka, Kolasa Wojciech
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.353-362, tab., bibliogr. 15 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The purpose of the study was to determine such cut-off points in the scores of General Helath Questionnaires (GHQ-12 and GHQ-28) that allow for optimal identification of people with mental health disorders in the Polish working population attending primary health care settings. The groups under the study covered 419 and 392 patients for GHQ-12, and GHQ-28, respectively. In the GHQ-12 group, 90 and in the GHQ-28 gropu, 80 subjects filled in the questionnaires and agreed to participate in the second stage of the study - a psychiatric interview. The criterion validity of the GHQs was a mental health diagnosis, based on the Munich version of Composite International Diagnostic Interview. The complete computerized version of interview, covering all daignostic sections, has been adopted. In the mental health diagnosis only disorders, whitch currently troubled patients were taken into consideration and disorders which created problems in the distant past were excluded. In the group covered by GHQ-12 examination, 55.6 p.c. of persons had at least one type of mental disorder diagnosed, based on the criteria of both Diagnostic and Statistical Manual for Mental Disorders (DSM-IV) and the International Classification of Diseases (ICD-10). In the GHQ-28 group, the percentage of persons with mental disorders was 47.5 p.c. After excluding patients with nicotine dependence disorder only, the frequency of mental health problems decreased to 45.5 p.c. After excluding patients with nicotine dependence disorder only, the frequency of mental health problems decreased to 45.5 p.c. and 33.8 p.c., respectively...


    2271/2523

    Tytuł oryginału: A prospective-controlled study of pregnant veterinary staff exposed to inhaled anesthetics and X-rays.
    Autorzy: Shuhaiber Samaer, Einarson Adrienne, Radde Ingeborg C., Sarkar Moumita, Koren Gideon
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.363-373, tab., bibliogr. 29 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płód
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Most veterinary staff are women of reproductive age. They are exposed to "waste" anesthetic gas and ionizing radiation in their workplace, which may endanger fetal safety. Presently, exposure of female veterinary staff to these health hazard has not been adequately addressed in the medical literature. Our primary objective was to investigate the incidence of major malformations associated with occupational exposure to inhaled anesthetics and/or radiation among pregnant veterinary staff. The secondary objective was to determine the rates of other adverse outcomes. We prospectively collected data on and followed-up women occupationally exposed to inhaled anesthetics and/or radiation in veterinary practices in Ontario, and compared them to controls matched for maternal age and gestational age at the time of call to the Motherisk Program. A total of 95 women were prospectively enrolled and followed-up. Among the participants there were 87 (93.5 p.c.) and 88 (92.8 p.c.) liverbirths in the study and control groups, respectively. There were 4 (4.8 p.c.) major birth defects in the study group and 3 (3.4 p.c.) in the control group. The rates of spontaneous abortion were also similar, 6 (6.4 p.c.) cases in the study group and 7 (7.4 p.c.) cases in the cotnrol group. These resutls suggest that Ontario female veterinary staff exposed to inhaled anesthetics and/or radiation do not seem to be at an increased rosk for major malformations above baseline risk.


    2272/2523

    Tytuł oryginału: Comparison of tissue distribution and metabolism of 1,2 - and 1,4-dibromobenzenes in female rats.
    Autorzy: Szymańska Jadwiga A., Sapota Andrzej, Wesołowski Wojciech, Czerski Bogdan, Piotrowski Jerzy K.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.375-383, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: The distribution, excretion and metabolism of 1,4-dibromobenzene (1,4-DBB) and 1,2-dibromobenzene (1,2-DBB), following a single intraperitoneal administration to female Wistar rats, were investigated using radiotracer 3H and GC-MS technique. The maximum level of 3H after 1,4-DBB administration was detected in all examined rat tissues between 4 and 24 h following the injection. The highest concentrations of 3H were found in fat tissue, muscles, adrenal glands and sciatic nerve. About 50 p.c. of administered dose was still retained in the rat 72 h after injection. For 1,2-DBB, the highest level of 3H was in the liver, kidneys and fat tissue 4 and 8 h after administration. Three days after injection, less than 2 p.c. of the given dose was retained in the rat body. Urine turned out to be the main route of 3H excretion following the injection of both compounds (30 p.c. and 82 p.c., after 1,4-DBB and 1,2-DBB, respectively), and about 4 p.c. of the given dose was excreted in feces. In urine of rats the following substances were indentified (in sequence 1,4-dBB and 1,2-dBB): (1) unchanged parent compounds (5 and 11 p.c.); (2) dibromophenols (84 and 73 p.c.); (3) dibromothiophenols (5 and 10 p.c.) and (4) monobromophenols (1.9 and 0.7 p.c.). This study suggets that 1,2-DBB is characterized by a relatively high turnover rate, whereas 1,4-DBB shows a tendency for long-term retention in the body.


    2273/2523

    Tytuł oryginału: Assessment of long-term neurotoxic effects of exposure to mesitylene (1,3,5-trimethylbenzene) based on the analysis of selected behavioral responses.
    Autorzy: Wiaderna Dorota, Gralewicz Sławomir, Tomas Tadeusz
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.385-392, il., bibliogr. 21 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Trimetylbenzene isomers: pseudocumene, hemimellitene and mesitylene, are major components of numerous commercial solvents and high-grade fuels. In our earlier research on rats we have proved that inhalation exposure to pseudocumene of hemimellitene at concentrations close to the MAC value resutls in behavioral changes detectable many weeks after cessation of the exposure. The aim of our present study is to determine whether exposure to mesitylene causes effects similar to those observed for pseudocumene and hemimellitene. Male rats were used in the experiment. The animals were exposed in the inhalation chambers to mesitylene vapors at the following concentrations: 0 ppm - group MESO; 25 ppm (125 mg/m3) - group MES25; 100 ppm (500 mg/m3) - group MES100 and 250 ppm (1250 mg/m3) - gropu MES250 for 4 weeks (6 h/day, 5 days/week). The following behaviors were tested: 1) ability to find water in a radial maze (14-19 days after the exposure); 2) open field locomotor activity (25 days after the exposure); 3) acquiring the conditioned reaction of active avoidance (35-45 days after the exposure); 4) sensitivity to pain and stress-induced changes of pain sensitivity (50-51 days after the exposure); and 5) acquiring the conditioned reaction of two-way active avoidance (54-60 days after the exposure). Significant between-group differences were noted in passive and active avoidance tests and sensitivity to pain. In the Mes25, MES100 and MES250 rats, the persistence of the passive avoidance reaction was shorter, and more trials were required to produce the active avoidance reaction than in controls (group MESO), the MES100 group appeared to be more fearful on the second day of testing on the hot plate...


    2274/2523

    Tytuł oryginału: Integrated indexes of occupational exposure as predictors of kidney dysfunction.
    Autorzy: Jakubowski Marek, Trzcinka-Ochocka Małgorzata, Hałatek Tadeusz, Raźniewska Grażyna, Szymczak Wiesław
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.393-399, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • medycyna pracy
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to evaluate the dose-effect and dose-response relationships between the integrated indexes Cd-A ú t (mg/m**3 ú years of exposure) and Cd-B ú years of exposure), and the increase in retinol binding protein excretion in urine (RBP-U) and á2-microglobulin concentration in serum (á2M-S). The study was carried out in the nickel-cadmium battery factory in 1998-1999. Exposure to cadmium was formerly very high. The study group consisted of 116 persons for whom the results of determinations of Cd-B were available during two former observation periods (1983 and 1986-1988). The mean age of the gorup was 49 years and the mean period of exposure was 17 years. The dose-effect relationship between Cd-B ú t and RBP-U or á2M-S was much better (r = 0.642 and 0.513) than between Cd-A út and RBP-U or á2M-S (r = 0.173 and 0.127). There was also correlation between Cd-U (ćg/g creatinine), measured in 1998-1999, and RBP-U or á2M-S (r = 0.343 and 0.198). Urinary cadmium should, however, be used with caution as a dose estimate because its excretion may increase as a result of renal damage. According to the dose-response relationship, an increase in RBP excretion above 300 ćg/g creatinine can be expected in 10 p.c. of subjects at the integrated exposure index (Cd-B ú t) of about 450 ćg/l ú years, and an increase in á2M-S above the accepted cut-off point of 2.4 mg/l can be expected in 10 p.c. of subjects at Cd-B ú t of about 190 ćg/l ú years. The data obtained confirmed the validity of the recommended at present health-based limit for occupational exposure of 5 ćg/l of blood, as well as the superiority of the biological monitoring of exposure to cadmium over the environmental monitoring.


    2275/2523

    Tytuł oryginału: Application of pylon radon daughter standard for calibration of radiometers.
    Autorzy: Chruścielewski Wojciech, Olszewski Jerzy, Bogusz Małgorzata
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.401-404, il., bibliogr. 4 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca techniczna

    Streszczenie angielskie: Radiometers for measurements of radon daughter potential energy used in the surveillance of the work environment need a systematic calibration. This paper presents how a commercially available device produced by the Pylon Company can be applied. This device allows to produce, simply and directly, standard sources of radon daughters, corresponding with the energy, geometry and properties of radiation originated from an air sample. The calibration yielded the resutls that proved to be in agreement with those obtained previously by means of radon chamber.


    2276/2523

    Tytuł oryginału: An investigative report on circumstances leading to death among Indian cotton farmers.
    Autorzy: Patil Rajan R.
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.405-407
    Sygnatura GBL: 306,313

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Andhra Pradesh, a southern state of India has been in the news for cotton farmers' deaths/suicides since 1998. The occurrence of 12 deaths among the farmers in the years 2001-2002 clustering around September-October expedited the investigation. The objective of our investigation was to identify the circumstances leading to death of cotton farmers in Warangal district of Andhra Pradesh. Some of the broadly held hypotheses were also analyzed for their validity. The socioeconomic-political factors emerge as very strong determinants of deaths, given the occupational work environment.


    2277/2523

    Tytuł oryginału: Polish bibliography of occupational medicine, 2001.
    Autorzy: Kowalczyk Grażyna, Przyłuska Jolanta
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.409-428
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • medycyna pracy

    Typ dokumentu:
  • tytuł obcojęzyczny
  • bibliografia


    2278/2523

    Tytuł oryginału: Manifestation of Churg-Strauss syndrome during osteoporosis treatment with hormone replacement therapy after steroid withdrawal.
    Autorzy: Somogyi Anikó, Mzes Gy”rgyi, Molnar Jeannette, Tulassay Zsolt
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.16-17, bibliogr. 5 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Allergic granulomatosis, otherwise called Churg-Strauss syndrome (CSS) is a rare type of allergic angitis and granulomatosis, whcih manifests in patients with bronchial asthma. The diseases belongs to the group of eosinophil pneumonias so there is a maekedly high eosinophil granulocyte count in the peripheral blood (20 - 40 p.c.). Systemic involvement is frequent and its prognosis is usually either satisfying or bad. Case Report: We report a case of a female patient with bronchial asthma, whose Churg-Strauss syndrome was manifested after the elimination of systemic corticosteroid therapy and introduction of estrogens (hormone replacement therapy - HRT) due to her progressing osteoporosis. The diagnosis of the disease was confirmed when her newly developed symptoms satisfied the ciriteria for classification of CSS by the American College of Rheumatology, as well as teh Chapel Hill Consensus Conference definition for CSS. Conclusions: This observation may bear great relevance since this combination of therapy could have triggered the onset of the life-threatening Churg-Strauss syndrome in our asthamtic patients. Previous data suggest that the withdrawal of steroid therapy triggers CSS. We should take into account the same risks when administering HRT to asthamtic patients with steroid-induced osteoporosis.


    2279/2523

    Tytuł oryginału: Hypothermic circulatory arrest in the management of massive pulmonary artery hemorrhage following pneumonectomy.
    Autorzy: Arrowsmith Joseph E., Cook Andrew C., Birdi Inderpaul, Ritchie Andrew J.
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.18-20, bibliogr. 11 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Massive hemorrhage from the divided pulmonary artery (PA) is a rare and lethal complication of pulmonary resection. In the early postoperative period the cause is invariably inadequate stump ligation, whereas in the alte postoperative period the cause is frequently pleural empyema secondary to bronchopleural fistula. Immediate resuscitation and surgical intervention are required to avert exsanguinations and death. Case report: We describe a case of life-threatening PA hemorrhage occurring within an hour of pneumonectomy. Initial resuscitation included the rapid infusion of cold blood and colloid directly into the distal aortic arch - a manoeuvre demonstrated to be neuroprotective in a canine model of exsanguination. At reoperation, repair of the torn pulmonary artery in teh face of ongoing hemorrhage proved to be impossible. Adequate surgical access could only be obtained following the institution fo cardiopulmonary bypass (CPB), adn ultimately hypothermic circulatory arrest (HCA). Despite prolonged periods of hypotension, massive transfusion of blood products and over 180 minutes of CPB, the patient rapidly made a complete recovery. Conclusion: CPB has been used successfully in a range of emergency situations including; major trauma, traumatic PA rupture, pulmonary embolism and hypothermia. To our knowledge thera appears to be only one published report of the use of CPB in the setting of PA hemorrhage during pulmonary resection. We ar not aware of any report of the successful use ofHCA in this clinical setting. In the seting of massive PA haemorrhage following pneumonectomy, theraefore, the use of CPB with HCA may be used to facilitate surgical repair with excellent clinical outcome.


    2280/2523

    Tytuł oryginału: Familial mediterranean fever in Romania - case report.
    Autorzy: Nanulescu Mircea V., Chereches-Panta Paraschiva
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.21-23, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Familial Mediterranean Fever (FMF), or periodic disease, is an inherited chronic inflammatory disorder that occurs mainly in the population of the Mediterranean area, adn it is exceptional in other ethnic groups. Case report: The authors present a case of a FMF obsrved in a member of a family from southern Romania without the typical ethnic background, and without family history of this kind of disorders. The onset of his symptoms was at the age of 4. Diagnostic aspects and differential criteria of other disorders characterized by recurrent fever with systemic involvement, mainly polyserositis, are presented. The authors insist on the role of adequate therapy that may prevent the onset of amyloidosis, which is a common complication in patients with FMF. Conclusion: The recognition and correct diagnosis of FMF is essential in order to avoid unnecessary diagnositc procedures and to apply the adequate therapy.


    2281/2523

    Tytuł oryginału: Case of neonate with Cantrell's pentalogy complicated by necrotizing enterocolitis.
    Autorzy: Zajączkowska-Sadlok Arleta, Koziołkiewicz Kazimierz, Korbal Piotr
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.24-27, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć męska

    Streszczenie angielskie: Background: Cantrell's pentalogy is a rare congenital defect syndrome, including hernia of the umbilical cord, diaphragmetic defect, abnormalities of teh sternum structure, preicardial defect and heart defect. Only 6 cases of children with the above syndrome who survived were described before 1996. Now, advances in intensive care and new surgical techniques allows to correct more congenital defects, thus making possible further development of the child. Case reprot: The paper presents a case of a neonate, born after full-term pregnancy, operated on the first day of life because of omphalocele, in whom detection of other anomalies contributed to the diagnosis of Cantrell's pentalogy with coplex heart defect in the form of Fallot's tetralogy. The post-operative course was additionally complicated by necrotizing enterocolitis, requiring exteriorization of the small intestine and long-term complete parenteral feeding. The enterostomy was closed in the 2nd month of life. Because of reterdation of psychomotor development, due probably to numerous repeated hospitalizations, the child underwent rehabilitation accordingto Vojta's method, which resulted in gradual development of motor and cognitive functions. The patient required close co-operation between the parents and physcicians representing many medical disciplines. Cardiosurgical consultation led to qualification of the boy for surgical correction of heart defects which is to be performed at the age of 1 year. Then the patient is scheduled or reconstruction of the abdominal integument. Conclusions: Therefore, Cantrell's pentalogy seems to be one of teh defect syndromes, in which survival and nearly normal development of the child is possible owing to advances in pediatric surgery, intensive care and therapy.


    2282/2523

    Tytuł oryginału: Case of Systemic Inflammatory Response Syndrome (SIRS) after autovaccination.
    Autorzy: Wojtacha Anna, Samborski Włodzimierz, Juszczyk Jacek
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.28-30, bibliogr. 9 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: Systemic Inflammatory Rsponse Syndrome (SIRS) is the response to an infectious factor or an non-infectious one, which differes this syndrome from sepsis. SIRS is diagnosed if 2 or more of the following criteria are met: temperature higher than 38řC or lower than 36řC; heart rate higher than 90 beats per minute; respiratory rate higher than 20/min or PaCO2 lower than 32 mmHg; white blood cell count greater than 12 G/l or kess tgab 4 G.k ir teg oresebce if nire tgab 10 immature bands. multiorgan failure, and often death, result from uncontrolled activation of the cascade of cellular and humoral mediators. Caser report: The case of SIRS in an 18-year-old female patient is described. During the 4 weeks preceding the onset of the first symptoms, the patient was receiving autovaccination against Staphylococcus aureus. The vaccination was done due to the culture from the throat smear. She received the last dose 3 days before the first sympotms. The onset of the disease was connected with high fever and hemorrhagic rush. After 24 hours, she developed shock with renal failure and syncope. After the next 2 days, gonarthritis was observed. The cultures of blood, urine, throat smear and arthritic liquid were negtive. She recovered after treatment with small doses of steroids. It is the first described case of Systemic Inflammatory Response Syndrome after autovaccination. Conclusions: 1. As a result of administration of a subsequent dose of autovaccine, release of inflammatory mediators was induced in the patient with consequent multiorgan function impairment. 2. The course of teh disease was very rapid and dramatic, requiring immediate institution of abti-shock therapy. 3. SIRS is a syndrome characterized by clinical presentation identical with sepsis. Differential diagnostics is very important because of different management of these two entities.


    2283/2523

    Tytuł oryginału: Interferon alpha in chronic hepatitis B treatment in a child with diagnosed linear IgA bullous dermatosis (LABD).
    Autorzy: Lebensztejn Dariusz Marek, Kaczmarski Maciej, Olkowska Bożena
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.36-39, bibliogr. 18 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Interferon alpha treatment is a first choice therapy in children with chronic hepatitis caused by HBV infection. Case report: The aim of the study was to present the IFN alpha applicaiton in chronic hepatitis ss a cause of HBV superinfection in a 9-year-old child with diagnosed linear IgA bullous dermatosis (LABD). During 20-week IFN alpha therapy we did not observe side-effects of the treatment; we observed HBeAg/antiHBe seroconversion, normalization of AlAT activity, regression of HBV DNA polymerase activity in blood serum and improvement of skin lesions. Conclusions: The disease history analysis of the treated boy indicates that application of IFN alpha in chronic hepatitis caused by HBV superinfection is possible in treatment of individual cases of children with autoimmunity disorders. The clear-sighted monitoring of liver function and autoimmunity parameters are recommended.


    2284/2523

    Tytuł oryginału: Case of lichen palmoplantaris with reactive lymphadenitis.
    Autorzy: Pietrzak Aldona, Lecewicz-Toruń Barbara, Krasowska Dorota
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.40-42, il., bibliogr. 7 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • hematologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Lichen planus, despite numerous studies devoted to it, still remains an enigmatic disease. To date, many clinical varieties of the disease have been described. One of them is localized on the skin of palms and soles. Clinical observations show this lichen variety to be exceptionally unresponsive to treatment. Case report: A case of a 36-year-old man with lichen planus Wilsoni is reported. The patient had extensive, heavily infiltrated lesions in his soles, palms annd oral mucous membrane. The skin symptoms were accompanied by enormous edema of the limbs and lymphadenitis. No concurrent hepatitis B and C virus infection was diagnosed. The pathogenesis of the case is unclear. At present, the patient reports no symptoms of the skin disease. conclusions: Lichen planus has been reported to be associated with liver disorders. Such an association did not occur in the reported case. Instead, the case suggests a possible association of lichen with the feet mycotic infection.


    2285/2523

    Tytuł oryginału: Ossifying tumor of a trunk.
    Autorzy: Chilarski Andrzej, Piaseczna-Piotrowska Anna, Fiks Tomasz, Łukaszek Stanisław
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.43-45, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Myositis ossificans and ossifying fibromyxoid tumor are rare entities. They share a lot of similarities as far as localization, clinical and radiological picture and outcome are concerned. Case report: The authors describe a case of a 15-year-old boy wo was operated on for ossifying tumor localized in the right lumbar region. Preoperataive X-ray adn CT revealed the tumor with clear borders of round shape and multiple calcifications, particularly towards the periphery. The boy made an uneventful postoperative progress. The histopathology of teh tumor was as follows: multiple mature osseous trabeaculae dispersed in richly vascularized matrix, the presence of multiple fibroblasts an dsome polynucllear cells. Immunohistochemistry showed NSE (neuron specific enolase)-positive and weakly vimentin-positive reactions. The results may suggest neural origin of the tumor. The differential daignosis of both entities: myositis ossificans and ossifying fibromyxoid tumor is discussed. In spite of immunohistochemistry, supporting the option of fibromyxoid tumor diagnosis, the specificity of these results is controversial and so the possibility fo myositis ossificans can not be excluded. Conclusions: In summary, the authors share the opinion suggesting the probability, at least in some cases, of common roots of the above mentioned diseases.


    2286/2523

    Tytuł oryginału: Garr‚ type periostitis ossificans: effective antibiotic therapy case report and literature review.
    Autorzy: Styczyński Jan, Biliński Piotr, Lasek Władysław, Gajewska-Guryn Anna, Wysocki Mariusz, Balcar-Boroń Anna
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.46-50, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • traumatologia i ortopedia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Garr‚ type periostitis ossificans is a rare disease observed in children and young adults. It is a chronic, infective pathologic change of bone tissue, with a mild course, affecting portions of long bone shafts and causing their sclerotization and thickening. Small granulation or cicatrization foci are present in teh marrow cavity, without purulence and bone defects. The predominant clinical symptom is dull pain, usually nocturnal. Generalized symptomsm or signs of local inflammation are rare. Case report: A course fo Garr‚ type periostitis ossificans located in the tibia of an 11-year-old boy is described. Laboratory tests and USG of the lesion site did not reveal any abnormalities. X-ray and CT images showed a spindle-shaped thickening of the tibial shaft, especially in the cortical layer, and narrowing of the marrow cavity, without periosteal reaction or soft tissue lesions. Scintigraphy of the skeletal system revealed enhanced radioligand uptake by the affected site. Differential diagnostics excluded osteogenci sarcoma, Ewing sarcoma, benign osteoma, cartilaginous tissue tumors, Langerhans cell histiocytosis and fibrous dysplasia. After antibiotic treatment, the clinical symptoms subsided. However, no evolution of radiological changes was observed. The boy has remained asymtomatic during 3-year follow-up. Conclusions: Garr‚ type periostitis ossificans should be taken into consideration in the differential diagnosis of bone diseases in children. The diagnosis is established on the basis of clinical and radiological presentation. Long-term antibiotic therapy may bring beneficial clinical effects. However, radiological changes of teh affected bone may persist for a long time.


    2287/2523

    Tytuł oryginału: Role of stereotaxic biopsy in modern neurosurgery.
    Autorzy: Jarus-Dziedzic Katarzyna
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.51-55, bibliogr. 30 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • neurologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The study presents the current views concerning the role of stereotaxic biopsy in diagnosis and treatment of brain tumors including surgical techniques, indications, complications, sensitivity, and specificity this method. The papers from the most important clinical centers are reviewed leading to a conclusion that stereotaxic biopsy is an efficient and safe method allowing to establish the diagnosis and to select the appropriate therapy. The presented paper was inspired by getting acquainted by the author during her research scholarship with the experience of the Clinic of Stereotaxic Neurosurgery in Freiburg. The Clinic, headed by Prof. Ch. Ostertag, is one of the leading centers in the world in the application of stereotaxic methods in neurosurgery.


    2288/2523

    Tytuł oryginału: Vpliv vrodzhenoi tomobofilii na rozvitok sindromu diseminovanogo vnutrishnosudinnogo zgortannja u ditej
    Autorzy: Zaryczański] [Janusz
    Źródło: - Opole, Oficyna Wydaw. Politechniki Opolskiej 2002, 40 s. : il., tab., bibliogr. 88 poz., streszcz., sum., 24 cm. - Tyt. oryg. Wpływ wrodzonej trombofilii na rozwój zespołu rozsianego wykrzepiania śródnaczyniowego u dzieci
    Seria: Studia i Monografie/Politechnika Opolska 133
    Sygnatura GBL: 660,864

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska


    2289/2523

    Tytuł oryginału: On Libet's experiments.
    Autorzy: Drozdek Adam
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (4) s.5-13, bibliogr. 19 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background and aim: In his experiments, Libet studied the time of the onest of conscious events and the time of neuronal activity associated with these events. The paper discusses interpretations of Benjamin Libet's experiments on the relation betweeen neuronal activity and consciousness. Material and method: A comparison is made with other experiments by Hans H. Kornhuber and Lder Deecke and Libet's findings are described and discussed in detail. Results and conclusion: In the comparison and taking into account other experiments the role of consciousness in initiating actions is much greater than judged by Libet.


    2290/2523

    Tytuł oryginału: Symptoms of paranoid schizophrenia and anxiety - a dynamic analysis.
    Autorzy: Śpila Bożena, Karakuła Hanna, Grzywa Anna
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (4) s.15-26, tab., bibliogr. 21 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Backgrounds and aim: The aim of the work was an analysis of connecting anxiety with other symptoms of paranoid schizophrenia during an episode of the disease. Material and method: 66 patients admitted to hospital with an episode of paranoid schizophrenia were examined by a set of tests. Exacerbation of anxiety was measured by the State Trait Anxiety Inventory (STAI), whilst symptoms of schizophrenia - by the Brief Psychiatric Rating Scale (BPRS) and the Scale for Assessment of Positive and Negative Symptoms (SANS, SAPS). Results: Statistically important correlations between anxiety and the majority of positive symptoms were observed. On the other hand, correlations between negative symptoms and the anxiety experienced by the sick appeared variously. Conclusion: There are significant correlations when analysing the connection between anxiety and other symptoms of paranoid schizophrenia during an episode of the disease.


    2291/2523

    Tytuł oryginału: Dysfunction of the hypothalamo-pituitary-adrenal axis in adolescents after a suicide attempt.
    Autorzy: Gmitrowicz Agnieszka, Kołodziej-Maciejewska Hanna
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (4) s.37-51, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • pediatria
  • psychiatria i psychologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background and aim: The objective of this research was to find whether there is a relation between the observed suicidal behaviours, mental disorders and dysfunction of the hypothalamo-pituitary-adrenal axis. Material and method: Two populations were subject of the research: 84 adolescents aged 14-21, after suicide attempts (ASA - drug overdose), never treated psychiatrically, and 30 adolescents after accidental intoxication (ACI). In each patient the serum levels of cortisol and ACTH were assessed, and the Dexamethasone Suppression Test (DST) was made. Results: Most patients in the ASA group were females. In this group statistically higher levels of cortisol after DST were found, as compared to the ACI group. Considering the patients' sex, the differences of serum cortisol levels were significant only in females. We found that higher cortisol levels in ASA were related to diagnosed depressive disorders (mostly in females), presence of psychological and enviromental problems, and elevated risk of repeated suicide attempt. Conclusion: In the examined group of 84 adolescents after suicidal poisonings a statistically higher serum cortisol levels after dexamethasone were found, a compared to the control group composed of 30 accidentally intoxicated adolescents.


    2292/2523

    Tytuł oryginału: Differences in the deprivation of needs among women and men in connection with the necessity of hospitalisation in the psychiatric ward.
    Autorzy: Ziarko Beata, Podbielski Zygmunt, Twardowska Marzena
    Źródło: Arch. Psychiatr. Psychother. 2002: 4 (4) s.53-58, tab., bibliogr. 5 poz.
    Sygnatura GBL: 313,554

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Beckground and aim: We aimed to study the differences in the deprivation of needs among women and men in connection with the necessity of being hospitalised in a psychiatric ward. Material and method: The study included 53 patients hospitalised in the Neuropsychiatric Hospital in Lubliniec (29 women, 24 men). We took into account the number of psychiatric hospitalisations, lenght of the present psychiatric hospitalisation and clinical diagnosis. As a clinical tool we used a questionnaire constructed especially for the study. The questionnaire is based on Murray's needs' conception. Results: Although the average value of the deprivation of needs for both examined groups appeared to be the same, differences appeared within the hierarchy of needs. There are statistically significant differences between men and women referring to the needs of getting to know new things, of reaching one's own ambition and sexual satisfaction. Conclusion: In certain aspects men and women differ significantly in the deprivation of needs when hospitalised.


    2293/2523

    Tytuł oryginału: Participation of yeast-like fungi in respiratory system diseases tuberculosis and neoplasms.
    Tytuł polski: Udział grzybów drożdżopodobnych w schorzeniach układu oddechowego - gruźlica i nowotwory.
    Autorzy: Dynowska Maria, Biedunkiewicz Anna, Sucharzewska Ewa
    Źródło: Acta Mycol. 2002: 37 (1/2) s.117-122, il., tab., bibliogr. [13] poz., streszcz.
    Sygnatura GBL: 305,328

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie polskie: Praca obejmuje wyniki badań (1997-1999) dotyczących występowania grzybów drożdżopodobnych w układzie oddechowym (plwocina, materiał bronchoskopowy) 1315 pacjentów Samodzielnego Publicznego Zespołu Pulmunologii i Onkologii w Olsztynie, u których rozwijał się proces nowotworowy i podejrzanych o gruźlicę. W analizowanej grupie osób większość pacjentów nowotworowych (452 osoby: 311 kobiet i 141 mężczyzn) była zakażona grzybami. Wyizolowano je od 280 kobiet - 90 proc. i 130 mężczyzn - 92 proc. Spośród 78 osób podejrzanych o gruźlicę i leczonych w tym kierunku seriami antybiotyków, tylko w dwóch przypadkach wychodowano prątki. U 76 osób prątków nie stwierdzono, mimo, że objawy kliniczne oraz badania radiologiczne wykazywały zmiany gruźlicze. Ogółem wyizolowano 9 gatunków grzybów z rodzaju: Candida, Saccharomycopsis i Trichosporon. Dominowała Candida albicans. Uzyskane wyniki potwierdzają negatywny wpływ nowoczesnej terapii antybiotykowej i przeciwnowotworowej, której następstwem jest drastyczny spadek odporności organizmu i uaktywnienie się grzybów potencjalnie chorobotwórczych często imitujących objawy innych chorób (m.in. gruźlicy).

    Streszczenie angielskie: The following paper contains the research results (1997-1999), concerning the presence of yeast-like fungi in the human respiratory system (sputum, bronchoscopy matertial) of 1315 patients of the Specialistic Public Hospital of Lung Diseases and Oncology in Olsztyn with the neoplasm development process and suspicion of tuberculosis. In the studied group the majority of patients with neoplasms (452 people: 311 female and 141 male) were infected with fungi. They were isolated from 280 women (90 p.c.) and 130 men (92 p.c.). Among 78 people suspicion of tuberculosis and treated with series of antibiotics only in two cases mycobacterium was obtained. All the 76 patients the presence of mycobacterium was not found, although, the clinical symptoms and radiological indicated tuberculosis. In total 9 species fungi were isolated; Candida, Saccharomycopsis and Trichosporon. The Candida albicans dominated. The results obtained confirm negative influence of the modern antibiotics and neoplastic diseases therapy, which succesion is the drastic decrease in cellular resistance ad activity pathogenic fungi often imitating symptoms other diseases (e.g. tuberculosis).


    2294/2523

    Tytuł oryginału: Fluidising effect of resorcylidene aminoguanidine on sarcolemmal membranes in streptozotocin-diabetic rats: blunted adaptation of diabetic myocardium to Ca**2+ overload.
    Autorzy: Waczulikova I., Ziegelh”ffer A., Orszaghova Z., Carsky J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4) p. 2 s.727-739, il., tab., bibliogr. 36 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The "remodeling" of cardiac sarcolemma in diabetes is belived to underline the reduced sensitivity of diabetic hearts due to their overload with extracellular calcium. Along with a non-enzymatic glycosylation and the free radical-derived glycxidation of sarcolemmal proteins there is ongoing reduction in cardiomyocyte membrane fluidity, the modular of cardiac sarcolemmal functioning. Aminoguanidine derivative, that inhibit glycation and glycoxidation, might suppress myocardium "remodelling" occurring in diabetic heart. To verify this hypothesis, we studied physical parameters of cardiac sarcolemma from the streptozotocin-induced diabetic rats (45 mg.kg**-1 i.m.) treated with resorcylidene aminoguanidine (RAG, 4 or 8 mg.kg**-1 i.m.). The treatment with RAG not only completely abolished protein glycation and a generation of free oxygen species (p 0.001) in treated diabetic animals, but also considerably attenuated the decrease in sarcolemmal membrane fluidity (p 0.001). In diabetic animals the "normalization" of the sarcolemmal membrane fluidity was accompanied by the vastly increased susceptibility of diabetic hearts to be overload with external calcium. We concluded that the decreased fluidity of the sarcolemmal membrane, apparently linked to the excessive glycation of sarcolemmal membrane proteins, might be intimately connected the adaptation mechanism(s) that are likely to develop in diabetic heart to protect it against to overload with external calcium.


    2295/2523

    Tytuł oryginału: Effect of cerebral ventricles perfusion with morphiceptin and met-enkephalin on trigeminohypoglossal reflex in rats.
    Autorzy: Zubrzycka M., Fichna J., Janecka A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.741-750, il., bibliogr. 30 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Opioids administered by intracerebroventricular injections produce analgesie responses in rats. The present study was undertaken to investigate the effects of a highly selective ć-opioid receptor ligand morphiceptin on trigemino-hypoglossal reflex in rats. The analgesic effect of morphiceptin was compared with another opioid peptide, Met-enkephalin. With the experimental settings used in the study, we have demonstrated that both morphiceptin and Met-enkephalin show significant dose-dependent analgesic effects after i.c.v. administration in rats as assayed by trigemino-hypoglossal reflex test. The antinonciceptive response to Met-enkephalin was short lasting and was observed 10 to 15 min after i.c.v. perfusion. Morphiceptin had a relatively longer duration of antinociceptive action, the effect was observed 20-50 min after i.c.v. perfusion. Neither morphiceptin nor Met-enkephalin produced antinociception after peripheral injections. The results of the present study indicate that both tested peptides act at ć-opioid receptors situated in the central nervous system. They also suggest that ć-opioid receptors present in the central nervous system are an important element of the trigemino-hypoglossal reflex arc. For that reason selective ć-opioid receptor ligands, like morphiceptin, inhibit the reflex more significantly.


    2296/2523

    Tytuł oryginału: Effects of thapsigargin on stimulation frequency - dependent changes in mitochondrial calcium in rat cardiac myocytes.
    Autorzy: Pytkowski B., Lewartowski B.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.751-759, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: We investigated in the single myocytes of rat heart the effect of blocking of ATP-ase of sarcoplasmic reticulum (SR) on mitochondrial Ca**2+ uptake and release. Mitochondrial Ca**2+ content was investigated as MN**2+ - resistant fluorescence of Indo 1- AM loaded into cells. SR ATP-ase was blocked with 10**-6 M thapsigargin (Tg). Tg blocked almost completely stimulation -dependent mitochondrial Ca**2+ uptake and slowed down its release despite that maximal Ca**2+ concentration was not decreased. We propose that mitochondrial stimulation -dependent Ca**2+ uptake is greatly enhanced by [Ca**2+] built SR in microdomains adjacent to these organelle.


    2297/2523

    Tytuł oryginału: The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions.
    Autorzy: Kwiecień S., Brzozowski T., Konturek P. Ch., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.761-773, il., bibliogr. 42 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The experimental model of acute gastritis such as water immerision restraint (WRS) stress-induced gastric injury is useful tool in examination of pathomechanism of acute gastritis. Nitric oxide (NO) plays an important role in the maintenance of gastric barrier, however, the interaction between reactive oxygen species (ROS) and NO on gastric mucosal integrity has been little studied. The purpose of our present study was to explain the participation of ROS in healing of WRS-induced gastric lesions accelerated by NO. Experiments were carrying out on 120 male Wistar rats. To assess gastric blood flow (GBF) laser Doppler flowmeter was used and the number of gastric lesions was counted in each stomach. The colometric assays were used to determine gastric tissue level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), the products of lipid peroxidation by ROS, as well as superoxide dismutase (SOD) activity, the enzyme scavanger of ROS. We demonstrated that 3.5 h of WRS resulted in appearance of acute gastric lesions accompanied by a significant decrease of GBF. Biological effects of ROS were estimated by measuring tissue levels of MDA and 4-HNE, as well as the SOD activity. It was demonstrated that 3.5 h of WRS led to significant increase of mucosal levels of MDA and 4-HNE, and it was accompanied by a decrease of SOD activity. Pretreatment with NO-donors (SIN-1, SNAP, nitroglycerin, NO-ASA) resulted in reduction in gastric lesion number, increment of GBF, decrease of MDA and 4-HNE tissue level and increase of SOD activity. Suppression of ROS plays an important role in the...


    2298/2523

    Tytuł oryginału: Influence of leptin administration on the course of acute ischemic pancreatitis.
    Autorzy: Warzecha Z., Dembiński A[rtur], Ceranowicz P., Jaworek J., Konturek P. C., Dembiński M., Bilski J., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.775-790, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Leptin is involved in the regulation of food intake and previous studied have shown that leptin affects the inflammatory response in various tissues. The objective of this study was to examine the influence of leptin administration on the development and the course of acute ischemic pancreatitis. Acute pancreatitis was induced by limitation of pancreatic blood flow by clamping of inferior splenic artery for 30 min, followed by reperfusion. Leptin was administered three times daily at the dose 10 or 50 ćg/kg. Animals were sacrificed 1, 3, 5, 10 and 21 days after removal of vascular clips. Administration of leptin reduced development of pancreatic damage and accelerated pancreatic regeneration what was manifested by the improvement of pancreatic histology, the decrease in serum lipase and amylase activity, and the reduction in serum interleukin-1á concentration. Also, treatment with leptin caused the increase in the pancreatic blood flow and pancreatic DNA synthesis. Leptin administration was without effect on serum interleukin-10 concentration. Leptin at the dose 50 ć/kg was more effective than 10 ćg/kg. We conclude that leptin reduces the pancreatic damage in the course of ischemic pancreatitis and accelerates the pancreatic tissue repair. The beneficial effects of leptin appear to be dependent on the improvement of pancreatic blood flow, the increase in pancreatic cell growth, and the limitation of pro-inflammatory interleukin-1á release.


    2299/2523

    Tytuł oryginału: Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat.
    Autorzy: Jaworek J., Konturek S[tanisław] J., Leja-Szpak A., Nawrot K., Bonior J., Tomaszewska R., Stachura J., Pawlik W. W.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.791-804, il., tab., bibliogr. 55 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study investigated the involvement of endogenous melatonin in the prevention of pancreatic damage provoked by caerulein-induced pancreatitis (CIP) by using the luzindole, the antagonist of melatonin MT2 receptors. CIP was produced by subcutaneous infusion of caerulein to conscious rats (25 ćg/kg). Luzindole (1, 2 or 4 mg/kg) was given as an intraperitoneal bolus injection 30 min prior to the start of CIP. Lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were measured in the pancreas by LPO-584 commercial kit. CIP was confirmed by histological examination and manifested by significant increases of plasma activities of amylase, lipase and tumor necrosis factor ŕ (TNFŕ) (by 500 p.c., 1000 p.c. and 600 p.c., respectively) comparing to the control values. This was accompanied by a 40 p.c. limitation in pancreatic blood flow (PBF) and by 200 p.c. increase of MDA + 4-HNE in the pancreas of CIP rats. Administration of luzindole to the CIP rats reduced PBF, aggravated the histological manifestations of pancreatitis, resulted in the significantaugmentation of pancreatic MDA + 4-HNE content, and produced the marked increases of plasma levels of lipase, amylase and TNFŕ, comparing to the values observes in the rats with CIP alone. These results suggest that endogenous melatonin through its receptor MT2, plays important role in the attenuation of pancreatic damage produced by overstimulation with caerulein.


    2300/2523

    Tytuł oryginału: MyHC II content in the vastus lateralis m. quadricipitis femoris is positively correlated with the magnitude of the non-linear increase in the VO2/power output relationship in humans.
    Autorzy: Żołądź J[erzy] A., Duda K., Karasiński J., Majerczak J., Kołodziejski L., Korzeniewski B.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.805-821, il., tab., bibliogr. 33 poz.
    Sygnatura GBL: 302,092

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: In the study we have examined the relationship between the content of different isoforms of MyHC in the vastus lateralis. m. quadricipitis femoris and the VO2/power output relationship during incremental cycling exercise. Twenty-one male subjects: aged 24.0 ń 2.5 years, body mass 73.0 ń 7.2 kg, height 179 ń 5 cm, BMI 22.78 ń 1.84 kg ú m-2, VO2max 3697 ń 390 ml ú min-1, 50.9 ń 5.2 ml ú kg-1 ú min-1, participated in this experiment. The subjects performed an incremental exercise test unit exhaustion. The wxercise test started at power output of 30 W, followed by an increase amounting to 30 W every 3 minutes. The pedalling rate was maintained at 60 rev min-1. Gas exchange variables were measured continuously using breath-by-breath system Oxycon Jaeger. At the end of each step blood samples were taken for lactate concentration. Muscle biopsy samples taken from the vastus lateralis m. quadricipitis femoris, using the Bergstrom needle, were analysed for the content of different MyHC (I, IIa, IIx) using SDS-PAGE and Western blotting. The pre-exercise VO2, as a mean value of six-minute measurements, expressed both in min-1, and in ml ú kg-1 ú min-1, was positively correlated with the content of MyHC II in the vastus lateralis (p 0.01). We have also found that the pre-exercise values of VO2 in the group of subjects with a high proportion of MyHC II (59.9 ń 11.2 p.c.) were significantly higher (p 0.02, when VO2, was expressed in ml ú min-1, and p 0.01 when VO2 was expressed in ml ú kg-1 ú min-1) than in the group with low content of MyHC II (27.5 ń 6.0 p.c.) in the vastus...


    2301/2523

    Tytuł oryginału: Neurokinin A and the neurohypophysial response to melatonin: in vitro studies.
    Autorzy: Juszczak M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.823-834, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • in vitro

    Streszczenie angielskie: The aim of this study was to investigate a possible role of neurokinin A (a member of a family of peptides known as tachykinins) in the pineal-neurohypophysial interrelationshiop. The effect of neurokinin A (NKA) alone or in the presence of pineal hormone - melatonin on basal and K+-stimulated vasopressin and oxytocin secretion from the hypothalamo-neurohypophysial system was studied in vitro. The present results show that NKA stimulated vasopressin and oxytocin release from the isolated hypothalamo-neurohypophysial system, when used at the concentration of 10-7 M/L. Melatonin diminished basal release of the neurohypophysial hormones; it also significantly inhibited the NKA-stimulated secretion of vasopressin and oxytocin. Lower concentrations of NKA did not affect the neurohypophysial hormones basal release, however, when melatonin was added to the medium enriched with NKA at the concentration of 10-9 M/L, the vasopressin secretion from the hypothalamo-neurohypophysial explants was decreased significantly. The K+-evoked release of neurohypophysial hormones was not further modified by either NKA or melatonin. The present results confirm previous reports as to inhibitory effect of melatonin on both vasopressin and oxytocin secretion from the hypothalamo-neurohypophysial comolex in vitro. However, under present experimental conditions, the contribution of NKA in the mechanisms of pineal-neurohypophysial interrelationship has not been demonstrated.


    2302/2523

    Tytuł oryginału: Involvement of prostaglandins in the nicotine-induced pituitary-adrenocortical response during social stress.
    Autorzy: Bugajski J., Gądek-Michalska A., Bugajski A. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.847-857, il., bibliogr. 31 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study examined the functional selectivity of nicotine for nicotinic acetylcholine receptors in the stimulation of the hypothallamic-pituitary-adrenal (HPA) axis, the effect of social crowding stress on HPA response to nicotine and the involvement of prostaglandins synthesized by constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2) in the nicotine-induced HPA response in rats crowded (24 per a box instead 7) for 7 days. Nicotine (2.5-5.0 mg/kg i.p.) significantly increased plasma ACTH and corticosterone levels measured 1 h after administration. Mecamylamine (50 mg i.c.v.), a selective nicotinic receptor antagonist, atropine (0.1 mg/kg i.p.) a non-selective cholinergic receptor antagonist, or COX inhibitors were injected 15 min prior to nicotine and the rats were decapitated 1 h after the last injection. Mecamylamine abolished the nicotine-induced ACTH response and significantly deminished corticosterone response. Atropine did not alter ACTH response and modestly diminished corticosterone response to nicotine. Crowding stress significantly impaired the nicotine-evoked ACTH and corticosterone secretion. Pretreatment with piroxicam (0.2-2.0 mg/kg), a COX-1 inhibitor, considerably diminished the nicotine-induced ACTH and corticosterone secretion in control and crowded rats. Compound NS-398 (0.2-5.0 mg/kg), a selective COX-2 blocker, did not markedly alter the nicotine-induced hormones secretion in either control or stressed rats. Indomethacin (2 mg/kg), a non-selective COX inhibitor diminished significantly, but to a lesser extent than...


    2303/2523

    Tytuł oryginału: Influence of several convulsants on the protective activity of a non-competitive AMPA/kainate antagonist, LY 300164, and lamotrigine against maximal electroshock in mice.
    Autorzy: Borowicz K. K., Świąder M., Zgrajka W., Sawulski C., Turski W. A., Czuczwar S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.859-869, tab., bibliogr. 32 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • pulmonologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Aminophyline (50-100 mg/kg) and strychnine (0.125-0.5 mg/kg) significantly raised the ED50 values of LY 300164 against maximal electroshock in mice, from 4 to 8 mg/kg (aminophylline 100 mg/kg) and from 3.6 to 11.5 mg/kg (strychnine 0.5 mg/kg). Also, aminophylline (25-50 mg/kg) and strychnine (O.125-0.25 mg/kg) increased the ED50 value of lamotrigine in this test, for instance from 5.5 to 8.0 mg/kg (aminophylline 50 mg/kg) and from 5.2 to 8.9 mg/kg (strychnine 0.25 mg/kg). Moreover, the ED50s values of aminophylline and strychnine for the reduction of the anticonvulsant effect of LY 300164 (7 mg/kg, the dose equal to its ED97 value against maximal electroshock) were 79.9 and 0.2 mg/kg, respectively. The respective ED50 values for the inhibition of the antiseizure action of lamotrigine were 40.9 and 0.2 mg/kg. Neither bicuculline nor picrotoxin affected the protective action of LY 300164 or lamotrigine. Strychnine significantly lowered the plasma concertrations of LY 300164 and this my point to a pharmacokinetic mechanism of the observed interaction. Aminophylline did not affect the plasma concentrations of the studied anticonvulsant drugs and strychnine - that of lamotrigine, so a pharmacokinetic interaction does not seem probable. The present results indicate that the potential of aminophylline and strychnine to attenuate the anticonvulsant activity of conventional antiepileptics is extended to LY 300164 and lamotrigine.


    2304/2523

    Tytuł oryginału: Democracy is healthier : a health miracle on the Vistula
    Autorzy: Zatoński Witold A.
    Wydanie: - Ed. 3 rev. and updated
    Źródło: - Warszawa, The M. Skłodowska-Curie Memorial Cancer Center and Institute of Oncology 2002, 16, [2] s. : il., 21 cm.
    Sygnatura GBL: 660,867

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • płeć męska
  • płeć żeńska


    2305/2523

    Tytuł oryginału: Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene.
    Autorzy: Cheng Z. J., Tikkanen I., Vapaatalo H., Mervaala E. M. A.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.597-613, il., bibliogr. 50 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • szczury

    Streszczenie angielskie: Ang II-induced endothelial dysfunction is associated with perivascular inflammation and increased superoxide production in the vascular wall. The present study examined the role of cyclo-oxygenase (COX)-synthetized eicosanoids in the pathogenesis of Ang II induced endothelial dysfunction in transgenic rats harboring mouse renin-2 gene (mREN2 rats). Five-to-six-week-old, heterozygous mREN2 rats received the following drug regimens for 8 weeks: 1) vehicle, 2) cyclo-oxgenase-2 (COX-2) inhibitor (MF-tricyclic [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl) phenyl)-2(5H)-furanone], 14 mg/kg p.o.), COX-1/COX-2 inhibitor (sulindac, 14 mg/kg p.o.), 4) angiotensin II receptor antagonist (losartan 40 mg/kg p.o.). Normotensive Sprague Dawley (SD) rats served as controls. In vitro vascular responses of the descending aorta and renal artery were studied using organ bath system. mREN2 rats developed pronounced hypertension which was associated with impaired endothelium-dependent and endothelium-independent vascular relaxations in the aorta. In contrast, the relaxation responses of the renal arteries remained largely unchanged in mREN2 rats. Urinary NOx excretion, a marker of total body NO generation, was also decreased in mREN2 rats. Neither non-selective COX inhibitor sulindac nor COX-2 selective MF-tricyclic were capable of preventing Ang II-induced hypertension or endothelial dysfunction in mREN2 rats, whereas ATireceptor antagonist losartan comletely normalized blood pressure, vascular relaxation responses ...


    2306/2523

    Tytuł oryginału: No-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by á-adrenoceptors or by 5 HT1A-receptors.
    Autorzy: Chłopicki S[tefan], Kozlovski V[alery] I., Gryglewski R. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.615-624, il., bibliogr. 19 poz., sum.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie
  • in vitro

    Streszczenie angielskie: Nebivolol is a unique á1-adrenoceptor antagonist which possesses peripheral vasodilator properties dependent on endothelial NO. Nebivolol-induced release of NO was attributed to its L stereoisomer and to its ability to stimulate endothelial á2, á3 adrenoceptors or 5 HT1A receptors. Here, in the isolated guinea pig heart we analysed coronary vasodilator potency of L- and D-nebivolol and a possible role of á2, á3 adrenoceptors and 5-HT1A receptors in nebivolol-induced vasodilation. Surprisingly, we ound that not only L-nebivolol (3-30x10**-6 M) but also D-nebivolol (3-30x10**-6 M) induced coronary vasodilation, and both responses were inhibited by L-NAME (10**-4 M). In contrast with the stereoisomers of nebivolol, atenolol at the equimolar concentrations did induce slight casoconstriction. The nonselective á1/á2-adrenoceptor antagonist - nadolol (10-5 M). The selective á3-adrenoceptor antagonist - L 748337 (10**6 M) and the 5 HT1A receptor antagonist - NAN 190 (5 x 10**-6 M), none of them inhibited coronary vasodilation induced by D- and L-nebivolol. In summary, in the isolated guinea pig heart both D- and L-nebivolol act as coronary vasodilators. Coronary vasodilation induced by stereoisomers of nebivolol is mediated by endothelium-derived NO and does not depend on á2, á3 adrenoceptors or 5 HT1A receptors.


    2307/2523

    Tytuł oryginału: Synthesis and thrombolytic activity of new thienopyrimidinone derivatives.
    Autorzy: Dupin J. P., Gryglewski R. J., Gravier D., Hou G., Casadebaig F., Swies J., Chłopicki S[tefan]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.625-634, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: It has been observed that ticlopidine and clopidogrel show, apart from their delayed antiplatelet properties, an immediate and transient thombolytic action related to the ability of these thienopyridines to stimulate the secretory function of vascular endothelium. With the objective to construct new molecules with identical thrombolytic potency but at a higher level, we carried out different structural modifications in the thienopyridine chemical molecule to conclude that the presence of a second N atom in the pyridine cycle (yielding pyrimidine moiety) and the presence of an additional cycle fused to the thienyl ring would lead to enhanced thrombolytic effects. Here we report the six-step synthesis of a series of new benzothienopyrimidinone derivatives characterized by this searched for potent thrombolytic activity. The pharmacological assay used anaesthetised Wistar rats with extracorporal circulation in which arterial blood superfused thrombi adhering to a strip of collagen. Weight of thrombi was continously monitored. Six compounds of the series were much more potent thrombolytic agents than their thienopyridine references: the effective thrombolytic dose that produced 30 p.c. of maximum thrombolysis (ED 30) was at a range of 8 to 170 ćg kg**-1 as compared with ED30 values of 16000 to 20000 ćg kg**-1 for clopidogrel and ticlopidine respectively. Especially with the most active compound, this difference in the threshold thrombolytic dose, giving an intnsity of action higher by three orders of magnitude, was ....


    2308/2523

    Tytuł oryginału: Misoprostol as agonist of IP2 receptor.
    Autorzy: Goszcz A[leksandra], Bieroń K[rzysztof], Grodzińska L[ilia]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.635-641, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Fourteen patients with peripheral vascular disease received 200 ćg of misoprostol 3 times a day during one month. The therapy with misoprostol caused clinical and biochemical improvement in all 14 patients. An elongation of pain free and maximum walking distance, shortening of pain duration and increase in arterial blood flow in both calves were observed. At the same time an activation of the fibrinolitic system, rise in the platelet aggregate ratio and increase in cAMP levels were noticed. It is suggested that misoprostol in human being caused rather activation of IP2 receptor.


    2309/2523

    Tytuł oryginału: Interleukin 1á induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells.
    Autorzy: Uracz W[ojciech], Uracz D[anuta], Olszanecki R[afał], Gryglewski R. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.643-654, il., bibliogr. 52 poz.
    Sygnatura GBL: 302,092

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Prostaglandin endoperoxide H2 (PGH2) is generated from arachidonic acid by either consitutive (COX)-1) or inducible (COX-2) cyclooxygenases. In arterial wall PGH2 is converted by PGI2 synthase (PGI-S) to prostacyclin (PGI2), and in plateles by thromboxane synthase (TX-S) to thromboxane (TXA2). Other prostanoids as PGD2, PGF2ŕ or PGE2 were belived to arise non-enzymatically from PGH2. Only recently , human prostaglandin E synthase (PGE-S) has been identified and cloned as a membrane bound, microsomal, glutathione-dependent inducible enzyme. Here we demonstrated that interleukin 1 á (IL-1á) is an inducer of COX-2 and PGE-S in human umbilical vein endothelial cells (HUVEC). Functional expression of PGE-S was measured at the level of specific mRNA by semi-quantitative RT-PCR, PGE-S protein was detected by Western blot in HUVEC, while PGE2 was measured by immunoassay in the supernatant. Actinomycin D, a classical transcription inhibitor, was used to prove that indeed IL-1á induced the functional PGE-S enzyme. PGE2 generation in HUVEC was inhibited by indomethacin, acetamoniphen and dexamethasone. In conclusion, we found that in cultured endothelial cells IL-1á induced as evidenced by the appearance of its transcript and its functional enzyme. The induction of endothelial PGE-S and COX-2 appeared to be and their transcripts were induced as fast as one might expect from immediate early genes. It means that IL-1á-triggered-PGE2 biosynthesis in endothelial cells is probably regulated by induction of both COX-2 and ...


    2310/2523

    Tytuł oryginału: Endothelial secretogogues and deformability of erythrocytes.
    Autorzy: Korbut R. A., Adamek-Guzik T., Madej J[ózef], Korbut R.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.655-665, il., bibliogr. 29 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Many diseases of the heart and circulatory system have been linked with both dysfunction of vascular endothelium and insufficient deformability of erythrocytes. Using shear stress laser diffractometry we investigated whether deformability of erythrocytes would be regulated endogenously by generation of two endothelial secretogogues: prostacyclin and nitric oxide. Experiments were performed in rats ex vivo and with whole blood or isolated erythrocytes in vitro. Iloprost - a stable analogue of prostacyclin (10 ćg/kg i.v.) and SIN-1 (NO-donor) at a dose of 2 mg/kg/min i.v. induced a significant improvement of deformability of erythrocytes ex vivo. Improvements of deformability by these two compounds were also evident in vitro when they were applied at a range of concentrations of 1 ćM and 3 ćM, respectively. Cyclooxygenase (indomethacin 20 mg.kg i.v.) and nitric oxide synthase (L-NAME 10 mg/kg i.v.) inhibitors while worsening deformability ex vivo, they did not affect (3 mM and ćM, respectively) rheological functions of erythrocytes in vitro. Aggravating effects of these inhibitors on erythrocyte deformability ex vivo were reversed by prostacyclin and nitric oxide supplemented exogenously. Aspirin at a low (1 mg/kg i.v.) and high dose (50 mg/kg i.v.), contrary to indomethacin and L-NAME, aggravated wrythrocyte deformability either ex vivo or in vitro. It is concluded that autocrine function of vascular endothelium plays an important role in regulation of rheology of red blood cells in flowing blood. The mechanism ...


    2311/2523

    Tytuł oryginału: The role of G protein B subunits in the release of ATP from human erythrocytes.
    Autorzy: Sprague R. S., Bowles E. A., Olearczyk J. J., Stephenson A. H., Lonigro A. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.667-674, il., bibliogr. 20 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Previously, we demonstarted that adenosine triphosphate (ATP) is released from human erythrocytes in response to mechanical deformation and that this release requires activation of a signal-transduction pathway involving adenylyl cyclase and the heterotrimeric G protein, Gs. Here we investigate the role of heterotrimetric G proteins of the Gi subtype in the release of ATP from human erythrocytes. In addition, we determined the profile of heterotrimeric G protein á submits present in these erythrocyte membranes. The activity of GI was stimulated by incubation of erythriocytes (20 p.c. hematocrit) with mastopain (10 ćM). ATP release was measured using the luciferin/luciferase assay. Heterotrimeric G protein á subunits present in erythrocyte membranes were resolved using gel electrophoresis and subunit specific antibodies. Incubation of human erythrocytes with mastoparan (an activator ofGi/o) resulted in a 4.1 ń 0.6-fold increase in ATP present in the medium (P 0.01). Human erythrocyte membranes stain positively for á subunit types 1,2,3, and 4, all of which been reported to activate of some isoforms of adenylyl cyclase. Activation of theheterotrimeric G protein, Gi, results in ATP release from erythrocytes. This effect is may be related to the activity of á subunits associated with this G protein in the human erythrocyte.


    2312/2523

    Tytuł oryginału: In vitro studies of activation of phagocytic cells by bioactive peptides.
    Autorzy: Stoika R. S., Lutsik M. D., Barska M. L., Tsyrulnyk A. A., Kashchak N. I.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.675-688, il., bibliogr. 22 poz.
    Sygnatura GBL: 302,092

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The effect of formyl chemotactic peptide (fCTP, fMet-Leu-Phe), á-amyloid peptides (á-AP, 1-42, 1-16 and 25-35), and bradykinin (BK) on functional activity of phagocytic cells has ben investigated. Wheat germ agglutinin (WGA) was also used as a model membrane binding agent of polypeptide nature. Murine monocytemacrophage cell line J774.2 and normal human blood polymorphonuclear (PMN) cells were used as target phagocytic cells. Their activity was quantitatively estimated by measuring phagocytosis of killed yeast cells. á-AP (1-41) maximally stimulated phagocytosis at 0.1 ćg/ml, ml, BK - at 1.0 ćg /ml, and fCTP - at 2.0 ćg/ml. á-AP (1-16) and á-AP (25-35) were inactive in used test-systems. Phagocytosis-inducing activity of á-AP (1-42) and BK reached maximal levels in 2 h and decreased after 4-6 h of incubation. Phagocytosis numbers were compared with the indicators of phagocytic cell activation, such as absorption of neutral red dye, glucose utilization, production of super-oxide anion (NBT-test) and nitrite accumulation (indicator of NO production). NBT-test, which may be related to the killing ability of phagocytic cells towards the ingested objects, was positive only in stimulated PMN leukocytes, while the nitrite accumulation was detected only in stimulated macrophages. Nitrite accumulation in macrophages was markedly induced by lipopolysaccharide and to a lower extent by 0.5 ćg/ml á-AP (1-42). In high dose (5.0 ćg/ml) á-AP suppressed nitrite accumulation in macrophages stimulated by lipopolysaccharide ...


    2313/2523

    Tytuł oryginału: Paradoxical augumentation of bradykinin-induced vasodilatation by xanthine/xanthine oxidase-derived free radicals in isolated guinea pig heart.
    Autorzy: Olszanecki R[afał], Kozlovski V[alery] I., Chłopicki S[tefan], Gryglewski R. J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.689-699, il., tab., bibliogr. 42 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • Świnki morskie
  • in vitro

    Streszczenie angielskie: Increased generation of reactive oxygen species contribute to endothelial dysfunction in atherosclerosis, hypertension and heart failure. Recently, it was suggested that bursts of superoxide anions may inactivate endothelial surface-bound enzymes such as angiotensin converting enzyme (ACE). Here, we tested effects of xanthine/xanthine oxidase-derived superoxide anions on vascular responses and ACE activity in the isolated guinea pig heart. We anlysed effects of intracoronary infusion of low concentration of xanthine oxidase (10 mU/ml) in the presence of xanthine (0,5 mM) (X/XO) on bradykinin, other endothelium-dependent and independent vasodilators (acetylcholine, ADP, SNAP), as well as vasoconstrictor responses to angiotensin I and angiotensin II. Surprisingly, X/XO significantly augumented coronary response to bradykinin without an effect on response to ADP, acetylcholine, SNAP, angiotensin I and angiotensin II. In contrast, inhibition of ACE by perindoprilate (100 nM) resulted in augumentation of bradykinin-induced vasodialidation as well as diminution of angiotensin I-evoked vasoconstriction without an influence on other responses. In summary, in the isolated guinea pig heart, X/XO-derived free radicals selectivity augumented coronary vasodilator response to bradykinin, which cannot be explained by X/XO-induced derangement of ACE. The mechanism of this paradoxical phenomenon, which might represent a defensive response of the coronary circulation to oxidative stress requires further investigations.


    2314/2523

    Tytuł oryginału: Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from g-irradiation.
    Autorzy: Soloviev A. I., Stefanov A. V., Tishkin S. M., Khromov A. S., Parshikov A.V., Ivanova I.V., Gurney A. M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.701-712, il., bibliogr. 19 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • szczury

    Streszczenie angielskie: The protective action of passive saline filled ("empty") phosphatidylcholine liposomes (PCL) omn endothelial function was examined in thoracic aortas obtained from gamma irradiated (6 Gy) Chinchilla rabbits, and then verified in experiments on non-anesthetized and anesthetized rats. Acetylcholine (ACh)-induced vascular relaxant responses in isolated vascular tissues rats were used as the test of endothelial integrity and its functional ability. It was shown that when added to the bath solution (100 ćg/ml), PCL effectively restored endothelium -dependent ACh relaxations of isolated vascular rings damaged resulting from g-irradiation but had no effect on endothelium-independent vascular responses to therapeutic nitric oxide (NO) donors. The liposomes were also without protective effect when injected to the rabbits intraperitoneally (30 mg/kg) 1 hour before irradiation. In contrast, PCL, being injected at the same dose 1 hour after radiation impact, promote normalization of both endothelium -dependent vascular responses to ACh and nitric oxide (NO) donors. PCL restored also the senitivity of vascular tissues to authentic NO (aqueous NO solution) that was surprisingly increased after irradiation, and normalized relationship between ACh-stimulated NO release and relaxant responseamplitudes in irradiated aortas. Experiments on non-anesthetized and anesthetized rats demonstrated that irradiation led to significant elevation in the level of arterial blood pressure without any changes in cardiac contractility....


    2315/2523

    Tytuł oryginału: Ultrastructural alterations of endothelium covering advanced atherosclerotic plaque in human carotid artery visualised by scanning electron microscope.
    Autorzy: Walski M., Chłopicki S[tefan], Celary-Walska R., Frontczak-Baniewicz M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.713-723, il., bibliogr. 29 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Human atherosclerotic plaque morphology at its various stages was extensively documented using light microscopy. However, much less is known of the ultrastructure of the human atherosclerotic plaque, in particular of ultrastructure of endothelial cells in atherosclerosis. Here, we annalysed alterations of endothelial cells covering advanced atherosclerotic plaque in carotid artery using scanning electron microscope. Examination was performed on specimens from atherosclerotic lesions of the interior carotid artery, collected from 8 patients who had undergone endarterectomy. We found wide spectrum of pathological alternations of the luminal surface of atherosclerotic plaque. In dominant part of the vessel, endothelial layer was preserved but displayed pronounced irregularities in endothelial architecture including appearance of cuboidal cells. Some endothelial cells were covered by numerous microvilli and/or contained "craters" disupting continuous surface of the endothelium. Platelets and leukocytes adhering to endothelium were frequently observed. There were also areas of the vessel lumen with endothelial denudation, in which the subendothelial surface containing fibrin proteins and collagen fibrils were visible. Interestingly, signs of proliferation of endothelial cells tending to cover the partially denuded vessel were observed. In summary, in scanning electron microscope, preserved endothelial cells of advanced atherosclerotic plaque displayed pronounced pathology; whether any of these changes represent the ultrastructural correlate of endothelial dysfunction remains to be estabilished.


    2316/2523

    Tytuł oryginału: Pressure and flow changes in the veins of the lower limb during activation of the calf muscle venous pump.
    Tytuł polski: Zmiany ciśnienia i przepływu w żyłach kończyn dolnych w czasie aktywacji pompy mięśniowej goleni.
    Autorzy: Recek Cestmir
    Opracowanie edytorskie: Rybak Zbigniew (koment.).
    Źródło: Prz. Flebol. 2002: 10 (4) s.83-90, il., bibliogr. 37 poz., streszcz.
    Sygnatura GBL: 313,489

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Zmiany ciśnienie w obrębie żył podudzi powstające podczas aktywności pompy mięśniowej łydki są siłą napędową krążenia żylnego kończyn dolnych. W bezruchu i w pozycji stojącej ciśnienie żylne odpowiada wartościom ciśnienia hydrostatycznego i jest identyczne zarówno w żyłach powierzchniowych, jak i w głębokich. W tej sytuacji nie obserwuje się refluksu żylnego. Powtarzalne skurcze mięśni łydki u zdrowej osoby powodują znaczące obniżenie ciśnienia zarówno w żylnym układzie powierzchniowym jak i głębokim podudzi, nie obserwuje się jednak tego zjawiska w żyle podkolanowej, jak i w udowej. Dlatego też powstaje gradient ciśnienia podczas ruchu między żyłami głębokimi uda i podudzia. Zjawisko to powoduje refluks żylny w przypadku żylaków pierwotnych, jak również może wywoływać następstwa prowadzące do nawrotu refluksu i nawrotu żylaków. Podczas skurczu mięśni goleni wyższe ciśnienie w żyle piszczelowej tylnej (PTV) wtłacza krew do żyły podkolanowej, jednak pewna ilość krwi ucieka drogą żył przeszywających do żyły odpiszczelowej (LSV), gdzie ciśnienie jest niższe w porównaniu z ciśnieniem panującym w PTV. Dalszy przepływ jest zgodny z prądem pnia żyły odpiszczelowej w kierunku żyły udowej. Podczas rozkurczu mięśni różnica ciśnień odwraca się: ciśnienie w obrębie PTV jest teraz niższe niż w LSV. W tej fazie krew jest zasysana z LSV do PTV. W ten sposób ma miejsce dwukierunkowy, wahadłowy przepływ zarówno u zdrowych osób jak i w przypadkach żylaków pierwotnych. Zmiany ciśnienia ...

    Streszczenie angielskie: Pressure changes in the veis of the lower leg occuring during activation of the calf muscle venous pump are the driving force of venous circulation in the lower extremity. In a motionless stating position venous pressure is determined by the hydrostatic pressure and is identical in superficial and deep veins. No reflux occurs in this situation. Repeated calf muscle concentrations in healthy subjects provoke a distinct pressure decrease both in deep and superficial veins of the lower leg, whereas no decrease occurs in the popliteal and femoral veins. In this way, ambulatory pressure gradient arises between deep veins of the thigh and the lower leg; it evoked venous reflux in primary varicose veins and may trigger the process leading to reflux recurrence and varicose vein recurrence. During calf muscle contraction the higher pressure in the posterior tibial vein (PTV) expels blood into the popliteal vein, but a part of the blood escapes via calf perforators into the long saphenous vein (LSV) where the pressure is lower in comparison with the PTV, and flows away within the stem of LSV into the femoral vein. During muscle relaxation the pressure difference turns round: the pressure in the PTV is now lower than in the LSV; in this phase blood is sucked from the LSV into the PTV. Thus, a bidirectional swinging flow takes place within calf performating veins both in healthy subjects and in primary varicose veins. Pressure changes which are produced in calf deep veins are ...


    2317/2523

    Tytuł oryginału: The promotion of happiness.
    Tytuł polski: Promocja szczęścia.
    Autorzy: Klamut Marian Kazimierz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.1-9, il., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Umysł ludzki posiada zdolność tworzenia świata wewnętrznego - sfery psychicznej, obejmujacej zjawiska charakterystyczne dla ludzkiej natury, takie jak: samoświadomość, świadome przeżycia, myślenie pojęciowe, język symboliczny, marzenia, sztukę, tworzenie kultury, poczucie wartości, zaineresowanie odległą przeszłoścą i troska o daleką przyszłość. Według wyjątkowo zgodnej opinii uczonych Wschodu i Zachodu właśnie w tym wewnętrznym świecie mieszka ludzkie szczęście. Szczęście to stan ducha, na który składają się: wewnętrzny spokój, zadowolenie z życia, radość istnienia, życzliwośći serdeczność wobec siebie i innych; wrażliwość na piękno przyrody, kulturę, sztukę; harmonijne współżycie z otoczeniem. Osiąganie i przeżywanie stanów tak rozumianego szczęścia zależy w głównej mierze od nas samych i podobnie jak to było w promocji zdrowia - wymaga wiedzy, chęci i możliwości. Promocja Szczęścia to lansowanie i upowszechnianie określonego sposobu myślenia i postępowania, to wytyczanie drogi prowadzącej do jak najczęstszego przeżywania szczęśliwych chwil.

    Streszczenie angielskie: The human mind is capable of creatig an internal world - the psychic sphere - including the phenomena characteristic of human anture, such as selfconsciousness, conscious experiences, conceptual thinking, symbolic language, dreams, art, creation of culture, sense of values, interest inteh distant past and care about the distant future. According to the exceptionally concordant opinions of the sages and scholars of the East and the West it is just within this internal world that human happiness dwells. Happiness is a state of the spirit which consists in: internal peace, satisfaction with one's life, the joy of life, benevolence and cordiality towards oneslf and towards others; sensitivity to the beauty of nature, culture and art; harmonoius co-existence with the surroudings. The achievement and experiencing of the states of thus understood happiness depend mainly on ourselves and, similarly to the project of health promotion, require knowledge, willingness and possibilities. Happiness Promotion denotes the commendation and popularizing of a certain definite way of thinking and acting - showing the road which leads to the frequent experiencing of happy moments.


    2318/2523

    Tytuł oryginału: Does ACE inhibitor modify the morphofunctional state of the nephron?
    Tytuł polski: Czy inhibitor ACE modyfikuje stan morfofunkcjonalny nefronu?
    Autorzy: Kifer-Wysocka Ewa, Romanowska-Sarlej Jadwiga, Matysiak Włodzimierz, Milewska Jolanta, Zakrzewski Paweł, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.10-14, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie polskie: Captopril, inhibitor konwertazy angiotensynowej (ACE), podawano szczurom białym w dwóch dawkach: 0,23 mg/dobę/szczura oraz 0,71 mg/dobę/szczura. Preparat aplikowano przez okres 3 tygodni. Obserwacje prowadzono w mikroskopie elektornowym. W nerkach zwierząt doświadczalnych obserwowano w komórkach kanalików proksymalnych rozrzedzenie cytoplazmy, liczne wakuole w apikalnej i przypodstawnej części komórki, poszerzenie przestrzeni miedzykomórkowych oraz liczniejsze lizosomy. Zmiany wyraźniej zaznaczone były u zwierząt otrzymujacych wyższą dawkę leku. Badania w mikroskopie elektronowym wykazały zmiany morfofunkcjonalne nefronu, związane z aplikacją preparatu Captopril. Stosowanie Captoprilu może przejściowo modulować stan morfofunkcjonalny niektórych struktur nefronu, co wykazano w niniejszym eksperymencie.

    Streszczenie angielskie: Captopril, the inhibitor of the angiotensin convertase (ACE) was administered to white rats in two doses: 0.23 mg/day/rat and 0.71 mg/day/rat. The preparation was being applied for the period of 3 weeks. Observations were carried out in a transmission electron microscope. In the kidneys of the animals subjected to the experiment, in the cells of the proximal canaliculi dilution of the cytoplasm, numerous vacuoles in the apical and basal part of the cell, dilation of the intercellular space as well as more numerous lysosomes were observed. The above-described changes were more distinctly marked in animals which were given a higher dose of the drug. The studies in the electron microscope revealed morphofuncitonal changes of the nephron related to the application of the Captopril. Application of the Captopril may temporarily modulate the morphofuncitonal status of certain structures of the nephron, which was demonstrated in the foregoing experiment.


    2319/2523

    Tytuł oryginału: Comparison of selenium distribution in mice organs after the supplementation with inorganic and organic selenium compound selenosemicarbazide.
    Tytuł polski: Porównanie zawartości selenu w narządach myszy po suplementacji nieorganicznym i organicznym związkiem selenu selenosemikarbazydem.
    Autorzy: Musik Irena, Kozioł-Montewka Maria, Toś-Luty Sabina, Donica Helena, Pasternak Kazimierz, Wawrzycki Sławomir
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.15-22, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy

    Streszczenie polskie: Badanie zawartości oraz funkcji selenu w organizmach żywych, podobnie jak innych pierwiastków, dostarczają interesujących wyników, jakkolwiek interpretacje nie zawsze są jednoznaczne. Celem naszej pracy było oznaczenie stężenia i dystrybucji selenu w poszczególnych narządach i tkankach myszy po suplementacji 4-(o-tolilo)- selenosemikarbazydu kwasu o-chlorobenzoesowego w porównaniu z nieorganicznym selenianem IV sodu. Badany związek oraz nieorganiczny selenian IV sodu podawano myszom SWISS w dawce 10**-3 g Se kg**-1 masy przez 10 dni. Stwierdzono pdowyższoną zawartość selenu w mózgu 31,98 mg g**-1 w grupie suplementowanej selenianem IV sodu, 38,04 mg g**-1 w grupie suplementowanej selenosemikarbazydem v s. z grupą kontrolną 26,18 mg g**-1. Kilkakrotny i istotny statystycznie wzrost zawartosci selenu stwierdzono w tkance płucnej 11.81 mg g**-1 po suplementacji selenosemikarbazydem, 6.79 mg g*-1 selenianem IV sodu v s. 1.75 mg g**-1. Również w mieśniach miedzyżebrowych stwierdzono nieistotny wzrost selenu na gram masy tkanki po suplementacji selenem nieorganicznym i istotny statystycznie wzrost stężenia po suplementacji selenosemikarbazydem 10,13 mg g**-1 w grupie pierwszej i odpowiednio 14,21 mg g*-1, v s. 28,84 mg g**-1. Nasze badania pozwalają na stwierdzenie, że związki organiczne selenu mogą być łatwiej przyswajalną formą Se w porównaniu z nieorganicznym selenianem IV sodu.

    Streszczenie angielskie: Studies on selenium organ content and its function in living organisms just like studies on other elements provide interesting results although their interpretation is not always clear. The aim of our study was to determine the concentration and distribution of selenium in several organs and tissues in mice after supplementation with our newly synthetized organic compound of selenium selenosemicarbazide (4-o-tolylselenosemicarbazide of o-chlorobenzoic acid) as compared to the effects of the supplementation iwth inorganic compounds. SWISS mice were fed with both types of compounds at the dose of 10**-3g Se per kg for the period of 10 days. The concentrations of selenium in brains of mice treated with selenocarbazide and sodium selenite were higher than in controls (38.04 ćg g**-1 and 32.00 ćg g**-1 vs. 26.18 ćg g**-1). There was a statistically significant increase in the selenium contents in lungs after supplementation with selenosemicarbazide and sodium selenite (11.81 ćg g**-1 vs. 1.75 ćg g**-1 in controls). We found a statistically insignificant increase in selenium contents in intercostal muscles after supplementation with inorganic selenium compounds and a statistically significant increase after the supplementation with selenosemicarbazide (10.13 ćg g**-1; 14.21 ćg g**-1 and 28.84 ćg g**-1, respectively). Our investigations lead to a conclusion that 4-o-tolyl-seleno-semicarbazide of o-chlorobenzoic acid, an organic selenium compound may be more easily absorbed than inorganic sodium IV selenite.


    2320/2523

    Tytuł oryginału: Prognostic value of the atrial pulsed Doppler recordings of transmitral flow in the assessment of left ventricular diastolic dysfunction.
    Tytuł polski: Wartość prognostyczna oceny czynności rozkurczowej lewej komory serca w oparciu o rejestrację napływu mitralnego z przedsionkowej lokalizacji bramki dopplerowskiej.
    Autorzy: Myśliński Wojciech, Mosiewicz Jerzy, Biłan Andrzej, Makaruk Bogusław, Jaszyna Maria, Hanzlik Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.23-32, tab., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Lokalizacja bramki dopplerowskiej jest jednym z wielu czynników wpływających w istotny sposób na wartości pomiarów rozkurczowego napływu do lewej komory. Średnie prędkości fal napływu mitralnego uzyskiwane z przedsionkowej lokalizacji bramki są niższe w porównaniu z wartościami rejestrowanymi na szczycie płatków zastawki mitralnej (lokalizacja komorowa). Niezależnie od lokalizacji bramki stosunek fal wczesnego (E) do późnego (A) napłwyu mitralnego (E/A) pozostaje stały, stąd E/A stanowi bardzo użyteczny wskaźnik oceny czynności rozkurczowej komory. U częsci chorych stwierdza się jednakże współistnienie odmiennych profili napływu mitralnego, z E/A 1 rejestrowanym w komorze i E/A 1 w obrębie przedsionka, odpowiadającym profilowi upośledzonej relaksacji komory. Cel pracy: Porównanie wyników badania echokardiograficznego lewej komory i lewego przedsionka u chorych z E/A 1, rejestrowanych zarówno z lokalizacji przedsionkowej, jak i komorowej, z chorymi reprezentujacymi odmienne profile napływu mittralnego. Materiał i metodyka: 51 pacjentów z E/A 1 w komorze, wykluczonym pseudonormalnym profilem napływu mitralnego, bez cech niewydolności serca, podzielono na dwie grupy. Grupa A - 26 chorych z E/A 1 w przedsionku i grupa B - 25 pacjentów z E/A 1 w przedsionku. U wszystkich chorych wykonano badanie M-mode lewej komory i lewego przedsionka. Wyniki: Chorzy z grupy A byli istotnie statystycznie starsi (55,5 ń 12,8 vs. 43,5 ń 10,5; p 0,001) oraz cechowali się ...

    Streszczenie angielskie: Volume sample location is the most important factor influencing pulsed Doppler recordings of left ventricular (LV) diastolic filling. Transmitral diastolic flow velocities measured at the tips of mitral valve leaflets are usually higher than those obtained from atriallocation. Nevertheless, independently of volume sample location, differences between early to late velocities ratio (E/A) are nosignificant, so E/A became the most useful index of ventricular diastolic performance. In some patients, however, with E/A 1 measured between the tips of mitral leaflets, the pattern of delayed LV relaxation, with diminished E and predominant A wave (E/A 1), is often obtained from left atrial volume sample location. The aim of our study was to compare LV dimensions and wall thickness between patietns with E/A 1 recorded both at the tips of mitral valve leaflets and in the left atrium and patients with E/A 1 at the tips of mitral valve leaflets and E/A 1 in the left atrium. The study population consisted of 51 patients with E/A 1 recorded between the tips of mitral valve (E/Avent) and excluded pseudonormalized filing pattern. The study population was divided into two groups based on Doppler profile recorded in the left atrium: group A- 26 patients with E/A 1 (E/Aatr) and group B- 25patients with E/Aatr 1. Patients from group A were significantly older (55.6 ń 12.8 vs 43.5 ń 10.5 yrs, p 0.001) and had increased body mass index (28.8 ń 4.4 vs 25 ń 4.1 kg/mý, p ...


    2321/2523

    Tytuł oryginału: Comparative analysis of the spirographic and hemodynamic parameters in preoperative evaluation of patients with lung cancer.
    Tytuł polski: Porównawcza ocena wartości badań spirograficznych i parametrów hemodynamicznych w przedoperacyjnej ocenie pacjentów z rakiem płuca.
    Autorzy: Stążka Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.33-41, il., tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie polskie: Wykonywane rutynowo przedopoeracyjne badanie spirograficzne, gazometrzyczne i elektrokardiograficzne w sytuacjach chorych w starszym wieku i/lub z towarzyszącym zaburzeniem wydolności krążeniowo-oddechowej zmuszają chirurga do oceny wydolności krążenia płucnego celem ostatecznej kwalifikacji chorych do leczenia operacyjengo. Celem pracy była próba oceny współzależności między wskaźnikami rutynowo wykonywanej spirografii a parametrami hemodynamicznymi krążenia płucnego. Badaniami objęto 50 kolejnych mężczyzn w wieku 21-72 lat (śr. 55,8) z rakiem oskrzela, kwalifikowanych wstępnie do zabiegu resekcji miąższu płucnego. U wszystkich pacjentów wykonano badanie spirometryczne, oznaczając VC proc., FEVV1 proc., FEV1a proc., badanie gazometryczne krwi obwodowej (PaO2, PaCO2, SaO2, pH) i mieszanej krwi żylnej (PvO2, PvCO2, SvO2, pHv). W oparciu o te parametry wyliczono Ci, SVR, PVR, LVSWI, RVSWI. Badania gazometryczne i hemodynamiczne wykonano w warunkach spoczynku i po wysiłku na ergometrze rowerowym przy obciążeniu 50 W przez okres 5 min. Uzyskany materiał poddano analizie statystycznej, wyliczając współczynnik korelacji "r" oraz współczynnik korelacji Spearmana. Badano kształt związku, stosując analizę regresji. Liczono proste regresji dla wskaźników, sprawdzając, czy współczynnik prostej regresji różni się istotnie od zera. Liczono również krzywe ufności przy poziomie istotności 0,01. Na podstawie przeprowadzonych wyliczeń stwierdzono wysoką współzależność miedzy FEV1 ...

    Streszczenie angielskie: Surgery is the recommended treatment for nonmicrocellular lung cancer. The spirometric tests completed with gasometric systemic blood analysis and electrocardciographic investigation are the standard in the evaluation for tolerance of lung tissue resection. The catheterization of the right heart is used to assess circulatory systems efficiency in patients qualified for pulmonary tissue resection. The purpose of the study was to evaluate the correlations between basic spirographic and hemodynamic parameters measured at rest and after exercise. The studied population consisted of 50 consecutive male patients 21 to 72 years old with bronchial carcinoma, considered to be candidates for lung tissue resection. The vital capacity, and one-second forced expiratory volume were obtained. The hemodynamic examination was performed using Swan-Ganz thermodilution catheter. The systolic, diastolic and medium central venous pressure, pulmonary artery pressure and pulmonary wedge pressure were measured. Gasometric examination for peripheral arterial and mixed venous blood was performed - pH, PO2, PaCO2, SaO2. The results were subject to statistical analysis. The corelation between spirographic indicators and hemodynamic parameters were studied. Statistical analysis revealed high level of correlation between the average blood pressure in pulmonary artery, both at rest and after exertion between the average blood pressure in pulmonary artery, both at rest and after exercise, and ratio ...


    2322/2523

    Tytuł oryginału: Comparative analysis of the gasometric and hemodynamic parameters in preoperative evaluation of patients with lung cancer.
    Tytuł polski: Przedoperacyjna ocena porównawcza parametrów gazometrycznych i hemodynamicznych u pacjentów z rakiem płuca.
    Autorzy: Stążka Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.42-48, tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie polskie: Badania spirograficzne, gazometryczne krwi tętniczej oraz elektrokardiograficzne są stosowane rutynowo u pacjentów kwalifikowanych do resekcji miąższu płucnego. U pacjentów z podwyższonym ryzykiem operacyjnym (zaawansowany wiek, współistniejące choroby układu krążeniowo-oddechowego, planowana rozległą resekcja) badania rutynowe należy rozszerzyć o scyntygrafię perfuzyjną płuc, a także o badanie hemodynamiczne krążenia płucnego. Celem badania była porównawcza ocena parametrów gazometrycznych i hemodynamicznych krążenia płucnego oraz próba wyliczenia równań prostych regresji na podstawie stwierdzonych współzależności. Badaniami objęto 50 mężczyzn w wieku 21-72 roku życia z rakiem płuca kwalifikowanych wstępnie do wycięcia tkanki płucnej. U wszystkich pacjentów wykonano badanie gazoemtryczne, mierząc pH, prężność tlenu, prężność dwutlenku węgla, wysycenie tlenem krwi tętniczej oraz mieszanej krwi żylnej, a także badanie hemodynamiczne krążenia płucnego, mierząc PAP, PCWP, CVP. Pomiary wykonywano w spoczynku i po obciążeniu pięciominutowym wysiłkiem 50 W na ergometrze rowerowym w pozycji leżącej. W oparciu o te wyniki obliczono CI, SVR, PVR. Uzyskane parametry poddano analizie statystycznej. Stwierdzono współzależności pomiędzy parametrami gazometrycznymi i hemodynamicznymi krążenia płucnego. Na ich podstawie wyliczono równania prostych regresji, pozwalające wyliczyć przybliżone wartości parametrów hemodynamicznych krążenia płcunego w oparciu o parametry gazometrii krwi tętniczej.

    Streszczenie angielskie: Measurements including spirographic examination, arterial blood gas tensions, standard electrocardiogram are routinely used to define risk factors for patients undergoing lung tissue resection. In some instances routine functional check-ups should be accompanied by the assessment of the hemodynamics of pulmonary circulation. The purpose of the study was to evaluate the correlations between gasometric parameters measured at rest and after exercise. In case of the presence of such correlations I wanted to find the principles to provide pulmonary artery hypertension in order to avoid right heart catheterization. The gasometric parameters in systemic and in mixed venous blood (pH, PaO2, PCWP, CVP) were measured in 50 male patients with lung carcinoma. All measurements were taken at rest and after an exercise test - 5 minutes, 50W workload on cycle ergometer in supine position. CI, PVR and SVR were calculated. The study proved statistically significant correlations beteween gasometric and hemodynamic parameters and made possible to calculate the regression lines equations, which help to predict pulmonary artery pressure before tissue resection.


    2323/2523

    Tytuł oryginału: Diagnotstic value of electrocardiographic investigations in preoperative evaluation of patients with lung cancer.
    Tytuł polski: Wartość diagnostyczna badania elektrokardiograficzego w przedoperacyjnej ocenie pacjentów z rakiem płuca.
    Autorzy: Stążka Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.49-54, tab., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie polskie: Badanie elektrokardiograficzne jest jednym z badań wykonywanych rutynowo u pacjentów z chorobami płuc, a szczególnie kwalifikowanych do leczenia oepracyjengo. Właściwa ocena przedoperacyjna wydolności układów oddechowego i krążenia zmniejsza ryzyko powikłań i zgonu pacjentów po zabiegu resekcji miąższu płucnego, co jest szczególnie istotne w zabiegach operacyjnych pacjentów z rakiem oskrzela. Celem badania było określenie wartosci badania elektrokardiograficznego w ocenie wydolności krążenia płucnego u pacjentów z rakiem płuca, kwalifikowanych do resekcji miąższu płucnego. Badaniami objęto 50 meżczyzn z rozpoznanym rakiem płuca. U wszystkich pacjentów oceniano parametry spirograficzne, hemodynamiczne, gazometryczne, starając się znaleźć współzależności z obrazem krzywej elektrokardiograficznej. Spośró 50 badanych pacjentów u 23 stwierdzono elektrokardiograficzne cechy przerostu prawego serca, przy czym tylko jeden z nich nie wykazywał nadciśnienia płucnego. Otrzymane wyniki poddano analizie statystycznej, stwierdzając korelacje między większością parametrów gazometrycznych, średnim ciśnieniem w tętnicy płucnej oraz FEV1 proc.

    Streszczenie angielskie: The pulmnary hypertension and cor pulmonale in patients before lung tissue resection must be predicted even if invasive studies are required. The purpose of the study was to evaluate the diagnsotic value of electrocardiogaphic investigation for patients with lung cancer, considered to be candidates for lung tissue resection. The study comprised 50 male patients with bronchial carcinoma before lung tissue resection. All of them had gasometric, and hemodynamic parameters of pulmonary circulaiton assessed at rest and after exercise. The ECG and spirographic investigations were done in all patients. It was found that 23 of 50 patients had electrocardiographic traits of right ventricle hypertrophy and only one of them had normal pulmonary circulation parameters. There were also found correlations between ECG curve and FEV1 p.c., mos of gasometric and some of pulmonary hemodynamic parameters.


    2324/2523

    Tytuł oryginału: The influence of interferon alpha on the rat liver injured by chronic administration of carbon tetrachloride.
    Tytuł polski: Wpływ interferonu alfa na uszkodzoną czterochlorkiem węgla wątrobę szczura.
    Autorzy: Mądro Agnieszka, Słomka Maria, Celiński Krzysztof, Chibowski Daniel, Czechowska Grażyna, Kleinrok Zdzisław, Karpińska Agnieszka
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.55-60, 6 tabl., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Celem pracy było badanie wpływu IFN alfa na parametry biochemiczne (aktywnosć A1At i AspAt) wątroby, wpływu na funkcję metaboliczną wątroby i jej stan morfologiczny badany w mikroskopie świetlnym i elektronowym po wcześniejszym uszkadzaniu CCl4 przez 3 i 6 tygodni. Doświadczenie przeprowadzono na szczurach samcach rasy Wistar. Do oceny funkcji wątroby używano testu eliminacji aminofenazonu w izlowanej, perfundowanej wątrobie szczura według metody Millera w modyfikacji Hafte'a. Oznaczano również aktywność AspAt i AlAt. Fragmenty wątrób badano w mikroskopie świetlny, elektronowym oraz przy pomocy metod immunohistochemicznych. Uzyskane wyniki wskazują na to, że po 3-tygodniowym uszkodzeniu wątroby CCl4 interferon alfa nie ma istotnego wpływu na aktywność AlAt i AspAt, niezależnie od stosowanej dawki. IFN alfa podawany szczurom po 6-tygodniowym uszkadzaniu wątroby CCl4 zmienia w istotnym zakresie aktywność AlAt i AspAt, gdy jest stosowany w dużej dawce. Stwierdzono, że czterochlorek węgla w dawkach i przez czas stosowany w naszym doświadczeniu nie wywołuje wyraźnych cech marskości wątroby szczurów, aktywuje jednak komórki Ito, powoduje ogniskowe zapadnięcie się zrębu i włóknienie. Zwiększenie liczby komórek Ito w przestrzeniach Dissego, wykazane immunohistochemicznie i ultrastrukturalnie, przemawia za aktywacją procesów włóknienia wątroby szczurów po podawaniu CCl4 w obu stosowanych wariantach. IFN alfa znacząco osłabia fibrogenezę w uszkodzonej CCl4 wątrobie, co wyraża ...

    Streszczenie angielskie: Due to their complex and not fully known etiopathogenesis as well as difficulties in treatment, chronic hepatitis and cirrhosis still remain one of the main problems of hepatologists. Nowadays, the use of OFN alpha is considered the most effective method of treatment in chronic hepatitis. Recently, a new property of IFN, i.e. its effects on the reduction of fibrosis, has been discovered. The aim of the paper was to examine the effects of IFN alpha on biochemical parameters (AlAt and AspAt acitivities), on the metabolic function of the liver and its morphologic picture observed under the light and electron microscope after the 3-and 6-week CCl4-induced damage. The experiments were carried out in Wistar male rats. To evaluate the liver function, the test of aminophenazone elimination in the isolated perfused rat liverswas used according to Miller modified by Hafte. Additionally, AspAt and AlAt activities were determined. The liver specimens were analysed under the light and electron microscope and using immunohistochemical methods. The findings show that after the 3-week CCl4-induced liver damage, IFN alpha does not significantly affect AlAt and AspAt activities, irrespective of the dose used. IFN alpha administered after the 6-week damage significantly changes those activities when the doses used are high. It was found that carbon tetrachloride does not result in evident cirhotic changes, however it activates Ito cells, causes focal retraction of the stroma and ...


    2325/2523

    Tytuł oryginału: Ultrastructural changes of ciliary epithelial nucleus in experimental diabetes - an animal model.
    Tytuł polski: Zmiany ultrastruktury jądra komórkowego epithelium ciała rzęskowego w przebiegu cukrzycy eksperymentalnej u zwierząt.
    Autorzy: Machowicz-Matejko Eulalia, Łańcut Mirosław, Jędrych Barbara, Zakrzewski Paweł, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.61-66, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta

    Streszczenie polskie: Przedmiotem pracy sa oceniane w mikrskopie elektronowym badania zmian w ultrastrukturze ciała rzęskowego gałki ocznej w przebiegu cukrzycy doświadczalnej, w różnych okresach trwania choroby u 15 królików rasy New Zealand. Zwierzętom podawano Alloxan w dawce 100 mg/kg m.c. w postaci 10-procentowego roztworu w fizjologicznym NaCl. Grupę badaną stanowiły zwierzęta, u których glikemia wyniosła 11 mmol/l lub więcej. Do oceny zależnych do czasu trwania cukrzycy zmian w jądrach nabłonka ciała rzęskowego zastosowano konwencjonalną mikroskopię elektronową. W badaniu zaobserwowano znaczne zmiany w ultrastrukturze jąder komórkowych. W zależności od czasu trwania cukrzycy występowały: głębokie wpuklenia błony jądrowej, rozszerzenia porów jądrowych, nieregularności w kondensacji chromatyny jądrowej, zmniejszenie wielkości i zmiany piknotyczne jąder komórkowych.

    Streszczenie angielskie: The aim of this study was to observe in electron microscope the New Zealand rabbits ciliary epithelia nucleus structure changes, depending on the duration of experimental diabetes mellitus. The animals were administered alloxan in the form of 10 p.c. solution in 0.9 p.c. NaCl, at the dose of 100 mg/kg b.m. If the glycemia leel was 11 mmol/l or higher the animal was included in the experimetnal group. 15 eyes of 15 adult New Zealand rabbits were studied. Conventional electron microscopy was used to show ultrastructural changes of ciliary epithelium nucleus. During the study we noticed severe chagnes in the structure of ciliary epithelial nucleus depending on diabetes mellitus duration. We found: deep indentations of nuclear membrane, open nuclear pores, irregularity in heterochromatin location and small sizes of the epithelial nucleus.


    2326/2523

    Tytuł oryginału: The influence of baclofen on reflex circulatory reactions evoked by stimulation of the vagus nerve in the rabbit.
    Tytuł polski: Wpływ baklofenu na reakcje krążeniowe wywołane drażnieniem nerwu błędnego u królika.
    Autorzy: Dyba Stefan, Tychowska Ingeborga, Klukowska Lidia, Nadulska Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.67-73, il., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie polskie: Celem naszych doświadczeń było zbadanie wpływu baklofenu na odruchowe zmiany ciśneinia tętniczego krwi i akcji serca, wywołane obustronnym drażnieniem nerwów błędnych. Doświadczenia przeprowadzono w narkozie uretanowej (1,5 g/kg) na 30 królikach mieszańcach obu płci o wadze 3000-4500. Średnie ciśnienie krwi i częstość akcji serca rejestrowano w tętnicy środkowej ucha pryz użyciu czujnika elektromagnetycznego i rejestrowane ono było na nośniku magnetycznym komputera. Drażniono dośrodkowe odcinki prawego, lewego i jednocześnie obu nerwów błędnych. Stosowane parametry drażnienia były następujące: częstotliwość 5c/sek., czas drażnienia - 20 sek., szerokość pojedycznego impulsu 1 msek. Siłę drażneinia wyrażano wielokrotnością pobudzenia progowego (1 T), za które uważano powtarzalny spadek ciśnienia wynoszący 2-4 mm Hg. Odstępy pomiędzy drażnieniami wynosiły 5 min. Baklofen podawano dożylnie w dawce 1,0 mg/kg masy ciała. W grupie kontrolnej toroweanie reakcji krążeniowych obserwowano jedynie przy najmniejszych intensywnościach drażnienia (1,0 - 1,5T). Przy silniejszych draznieniach suma efektów jednostronnych była większa od wielkości uzyskiwanych podczas jednoczesnego obustronnego drażnienia nerwów błędnych. Ten efekt okluzji narastał w miarę zwiększania siły bodźca do wielkości 4-5T. Po podaniu baklofenu zjawisko torowania przy najmiejszych itnensywnosciach siły bodźca znikało. Obserwowano jedynie okuzję. Baklofen podnosił średnie ciśnienie krwi tętniczej o 15 ń 6 mm Hg ...

    Streszczenie angielskie: The purpose of our investigations was to investigate the effect of baclofen upon the reflex fall of arterial blood pressure and heart rate evoked by stimulation of bilateral vagus nerves. The experiments were carried out on 30 rabbits of both sexes and mixed breed weighing 3000-4500 g under urethane anaesthesia (1.5 g/kg). Mean arterial pressure and heart rat ewere measured in the ear middle artery by the electromanometer and registerd by PC computer. Parameters of stimulation were: frequency 5 c/s., duration - 20 s., width of single rectangula pulse - 1 msec., itnensity of stimulation - multiplicity of threshold excitation (T). The intervals between stimulations were not shorter than 5 min. Baclofen was administrated intravenously (1.0 mg/kg). In the control group the facilitation of circulatory reaction was observed only at the smallest intensity of stimulation (1.0T-1.5T). When greater intensity of stimulations was applied the sum of unilateral effects was greater than the effect of simulatneous bilateral vagus nerve stimulation. This occlusion effect increased up to the stimulus value of 4-5T. After baclofen adminsitration the facilitation of circulatory responses disappeared and only occlusion was observed. Baclofen increased the size of the area of active overlapping of the afferent innervation of the vagus nerve. Administration of baclofen produced an increase in mean arterial blood pressure (15 ń 6 mm Hg) and heart rate (16 ń 5 beats per minute) and decrease ...


    2327/2523

    Tytuł oryginału: Emotional responses of patients with schizophrenia to their illness. Attitudes of social environment towards schizophrenes.
    Tytuł polski: Reakcje uczuciowe chorych na schizofrenię wobec swojej choroby. Postawy otoczenia społecznego wobec schizofreników.
    Autorzy: Żołnierczuk-Kieliszek Dorota, Żak Barbara
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.74-82, il., bibliogr. 7 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było określenie reakcji uczuciowych pacjentów z rozponaną psychozą z kręgu schizofrenii wobec swojej choroby. Zamierzano też poznać postawy rodzin i dalszego otoczenia społecznego wobec chorych. Badaniem objęto 84 pacjentów Szpitala Neuropsychiatrycznego w Lublinie, zarówno hospitalizowanych na Psychiatrycznym Oddziale Rehabilitacji, jak i leczoncyh ambulatoryjnie w Poradni Zdrowia Psychicznego oraz korzystajacych równocześnie ze Środowiskowego Domu Samopocy "Misericordia". Wszyscy badani chorzy spełniali kryteria diagnsotyczne według ICD-10 dla psychozy schizofrenicznej lub zaburzenia schizoafektywnego, wszyscy byli w okresie remisji objawowej. Badanie przeprowadzono w latach 2000-2001, wykrozystując technikę ankiety rozdawanej. Uzupełniającym źródłem informacji były historie chorób badanych pacjentów. Dominującymi uczuciami u schizofreników w momencie uświadomienia sobie zachowania na chorobę psychiczną były lęk i smutek. Upływ czasu wpłynął na zmianę reakcji uczuciowych wobec choroby psychicznej. W chwili badania przeważały akceptacja choroby i poczucie mniejszej wartości z jej powodu. Chorzy na schizofrenię spotkali się przede wszystkim ze współczuciem i ackeptacją swojej choroby ze strony najbliższej rodziny oraz z akceptacją choroby i obojętnością w dalszym otoczeniu społecznym.

    Streszczenie angielskie: The aim of this paper was to define emotional responses of the patients with diagnosed schizophrenic psychosis to their illness. It was also intended to recognize the attitudes of paitents' families and more distant social environment towards them. The study was conducted on 84 patients of the Neuropsychiatric Hospital, both hospitalized and amblant, treated in Mental Outpatient Clinicl and, simultaneously, taken care of by Social Self-help Home "Misericordia". All the examined patients met the diagnostic criteria in accordance with ICD-10 for schizophrenic psychosis or schizophrenic disorder; all were in the period of symptomatic remission. The study was carried out in the years 2000-2001, using the distributed inquiry questionnaire technique. The supplementary soure of information was case records of the examined patients. The predominant feelings of schizophrenics at the moment of becoming aware of having fallen ill with mental disease were fear (anxiety) and sorrow. The passage of time caused changes in emotional responses tomental illness. At the moment of the study the predominant feelings were the acceptance of illness and the sense of inferiority because of it. The sufferers of schizophrenia experienced mainly sympathy, acceptance of the illness and indifference in the environment outside the family circle.


    2328/2523

    Tytuł oryginału: Changes in epidemiology of viral hepatitis in Poland at the end of the 20th century.
    Tytuł polski: Zmiany w epidemiologii wirusowego zapalenia wątroby w Polsce w końcu XX wieku.
    Autorzy: Kalinowski Paweł
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.83-89, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • choroby zakaźne

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • historia XX wieku

    Streszczenie polskie: Wirusowe zapalenia wątroby (WZW) są, obok grypy, najczęściej rejestrowanymi chorobami zakaźnymi na świecie. W niniejszej pracy analizowao dane epidemiologiczne dotyczące ilości przypadków wirusowych zapaleń wątroby zarejestrowanych na terenie Polski w latach 1990-2000. Przeanalizowana liczba zachorowań, zapadalność, liczbę zgonów i śmiertelność z powodu wirusowych zapaleń wątroby różnych typów. Zapadalność na wzw wszystkich typów rosła w Polsce do roku 1993, by po roku 1993 gwałtownie spaść, głównie za sprawą spadku zapadalności na wzw typu A. Zarejestrowano malejący trend zapadalności na wzw typu B, który uległ wyraźnemu nasileniu po roku 1993, a więc od czasu wprowadzenia masowych szczepień profilaktycznych. Od rozpoczęcia rejestracji wzw typu C w roku 1997 liczba potwierdzonych laboratoryjnie przypadków tej choroby podwoiła się. Umieralność na wszystkie typy wzw w latach 1990-2000 w Polsce zmniejszyła się dwukrotnie.

    Streszczenie angielskie: Viral hepatitis is, apart from influenza, the most often registered infectious disease in the world. The material comprised epidemiological data concerning the number of cases of viral hepatitis registered in Poland in the years 1990-2000. There were analysed the number of cases, incidence, number of deaths adn mortality from viral hepatitis of different ypes in Poland in the years 1990-2000. The incidence rates from all types of viral hepatitis have been increasing in Poland until 1993 and decreased abruptly after 1993, mainly due to the diminution of number of cases of viral hepatitis type A. There was registered a decreasing trend in incidence rates of viral hepatitis type B that was significantly intensified after 1993, i.e. since the year when mass prophylaxis vaccinations have been initiated. Since registration of cases of viral hepatitis type C was started in1997, the number of analytically confirmed cases of this disease has doubled. mortality from al types of viral hepatitis has decreased twofold in Poland in the years 1990-2000.


    2329/2523

    Tytuł oryginału: Diagnostic imaging of ameloblastoma.
    Tytuł polski: Diagnostyka obrazowa szkliwiaka.
    Autorzy: Różyło-Kalinowska Ingrid
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.90-97, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • radiologia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Omówiono wartość różnych technik obrazowania diagnostycznego w szkliwiaku na podstawie analizy zdjęć rentgenowskich i wyników badań obrazowych pacjentów badanych w AM w Lublinie w latach 1995-2000. Stwierdzono, że diagnostyka obrazowa szkliwiaka wymaga zarówno konwencjonalnej rentgenodiagnostyki, jak też zastosowania nowoczesnych technik obrazowania, takich jak tomografia komputerowa i tomografia magnetycznego rezonansu jądrowego. Korelajca wyników badań metodą tomografii komputerowej i tomografii magnetycznego rezonansu jądrowego jest niezbędna w przypadkach wznowy pooperacyjnej.

    Streszczenie angielskie: The value of various radiolgoical techniques in cases of ameloblastoma was discussed on the basis of analysis of radiograms and the results of diagnostic imaging methods of patients examined in the Medical University of Lubin in the years 1995-2000. It was concluded that diagnostic imaging of ameloblastoma requires both conventional radiograms and modern imging techniques such as computed tomography and magnetic resonance imaging. It is imperative to correlate the results of computed tomography and magnetic resonance imaging in cases of recurrence.


    2330/2523

    Tytuł oryginału: Radiodensitometric measurements in cases of chronic periapical changes of endodontically treated teeth.
    Tytuł polski: Pomiary radiodensytometryczne w przypadkach przewlekłych zmian okołowierzchołkowych zębów leczonych endodontycznie.
    Autorzy: Różyło-Kalinowska Ingrid, Czelej-Górski Jolanta, Różyło T. Katarzyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.98-105, il., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy była ocena radiodensytometryczna tkanek twardych korzeni i wyroskta zębodołowego zębów leczonych endodontycznie z klinicznie stwierdzanymi objawami zmian okołowierzchołkowych. Materiał stanowiło 139 cyfrowych rentgenowskich zdjęć wewnątrzustnych zębów leczonych endodontycznie z przewlekłymi zmianami okołowierzchołkowymi. Były to radiogramy 54 zębów ze zmianami ziarninowymi, 62 ze zmianami włóknistymi i 23 ze zmianami o charakterze ropnym. Omówiono wartość radiografii cyfrowej i radiodensytometrii w przypadkach zmian zapalnych okołowierzchołkowych zębów leczonych endodontycznie. Stwierdzono, że pomiary radiodensytometryczne pozwalają na dokładną ocenę zmian zapalnych przy wierzchołkach zębów leczonych endodontycznie. Radiografia cyfrowa jest wartościowym i obiektywnym narzędziem w diagnostyce takich zmian oraz monitorowaniu postępów leczenia endodontycznego. Jednocześnie pozwala na zredukowanie dawki promieniowania rentgenowskiego, co zmniejsza ryzyko diagnostyczne dla pacjenta.

    Streszczenie angielskie: The purpose of the paper was radiodensitometric evaluation of hard tissues of roots and alveolar bone of endodontically treated teeth with clinically detected chronic periapical inflammatory changes. The material consisted of 139 digital intraoral radiograms of endodontically treated teeth with chronic periapical changes: 54 teeth with granulomatous inflammation, 62 with fibrous changes and 23 teeth with purulent lesions. There was discussed the value of digital radiography and radiodensitometric measuremetns in cases of periapical inflammations of endodontically treated teeth. It was concluded that radiodensitometric measurements allowed detailed examinations of inflammatory changes at the apices of endodontically treated teeth. Digital radiography is a valuable and objective tool in diagnosis of periapical changes, monitoring of the course of endodontic treatment as well as infollow-up after such treatment. At the same time if allows reduction of ionising radiation dose, thus decreasing diagnostic risks to a patient.


    2331/2523

    Tytuł oryginału: Optimisation of conditions of visualisation of dental crowns in dental radiography.
    Tytuł polski: Optymalizacja warunków wizualizacji koron zębów w radiografii cyfrowej.
    Autorzy: Michalska Anna, Różyło-Kalinowska Ingrid, Jurkiewicz-Mazurek Magdalena, Różyło T. Katarzyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.106-112, [2] s. tab., bibliogr. 20 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Cyfrowe zdjęcia rentgenowskie są alternatywą dla knwencjonalnych radiogramów. W pracy omówiono możliwości zastosowania różnych opcji obrazowania w radiografii cyfrowej oraz pomiarów gęstości w optymalizacji diagnostyki zmian patologicznych koron zębów. Przeanalizowano 1491 zdjęć zębowych wewnątrzustnych, wykonanych u 985 osób w systemie radiografii cyfrowej Digora Soredex. na wszystkich wykonanych zdjęciach oceniano: korony zębów pod kątem obecności próchnicy pierwotnej i wtórnej, wypełnień, resorpcji wewnętrznej, zmian pourazowych w zębach przednich, stosunku dna głębokich ubytków próchnicowych do rogów miazgi oraz do rozwidlenia korzeni. Ponadto próbowano również ocenić możliwości różnicowania próchnicy z niecieniującym wypełnieniem lub podkładem, a także odróżniania zmian próchnicowych w okolicy przyszyjkowej z przejaśnieniami przyszyjkowymi. Wskazno optymalne funkcje oprogramowania, przydatne w diagnostyce poszczególnych omawianych zmian patologicznych.

    Streszczenie angielskie: Digital X-ray imaging systems are an alternative to conventional intraoral radiograms. In the paper there are discussed the possibilities of applicaiton of different digital radiography tools as well as density measurements in optimization of diagnostics of patholgoical lesions of teeth crowns. There were analyzed 1,491 digital intraoral radiograms obtained in 985 patients in the Digora Soredex digital radiography system. On all taken X-ray pictures there were evaluated the crowns of teeth in cases of primary and secondary caries, dental fillings, internal resorption, traumatic lesions of incisors as well as the relationshipsbetween deep carietic lesions and pulp horns as well as root furcation. An attempt was made to assess the possibilities of differentiation of cervical caries and crevical burn-out. In the paper there were presented the optimal options of digital radiography software in diagnostics of the discussed pathological lesions.


    2332/2523

    Tytuł oryginału: Prevalence of human papillomavirus and Chlamydia trachomatis infections in cervical dysplasia and carcinoma.
    Tytuł polski: Częstość występowania infekcji HPV i Chlamydia trachomatis w dysplazji i raku szyjki macicy.
    Autorzy: Pochylski Tomasz, Gąsowska Urszula, Kwaśniewska Anna
    Źródło: Kolposkopia 2002: 2 (3) s.47-52, tab., bibliogr. 36 poz., sum.
    Sygnatura GBL: 313,653

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • mikrobiologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: W rozwoju karcinogenezy szyjki macicy podkreśla się rolę koinfekcji wirusowej i bakteryjnej. Pogląd, że rak szyjki macicy jest chorobą przenoszoną drogą płciową (ang. sexually transmitted disease - STD) rozszerzył obszar poszukiwań innych czynników przenoszonych drogą płciową i coraz częściej przedmiotem badań staje się również bakteria Chlamydia trachomatis oraz wirusy Herpes simplex. Cel pracy. Ocena częstości występowania DNA wirusów brodawczaka ludzkiego HPV oraz Chlamydia trachomatis w nabłonku: raków płaskonabłonkowych szyjki macicy, dysplazji dużego stopnia szyjki macicy (CIN III) oraz prawidłowym szyjki macicy, pochodzącym od kobiet operowanych z powodu mięśniaków macicy. Materiał i metody. Grupę badania stanowiło 35 tkanek pooperacyjnych z rozpoznaniem dysplazja dużego stopnia oraz 29 tkanek pooperacyjnych z rozpoznaniem: rak płaskonabłonkowy szyjki macicy. Grupę kontrolną stanowiły tkanki prawidłowej szyjki macicy uzyskane od 33 pacjentek operowanych z powodu mięśniaków macicy. W celu identyfikacji wirusowego kwasu deoksyrybonukleinowego w DNA izolowanym z materiału pooperacyjnego kobiet grup badanych (CIN III oraz Carcinoma) i kontrolnej, przeprowadzono PCR z zastosowaniem starterów o sekwencjach komplementarnych do różnych typów wirusa HPV (primer uniwersalny, oceniający istnienie 33 typów HPV oraz typy: HPV 16 i HPV 18). PCR posłużyło również do identyfikacji infekcji Chlamydia trachomatis (stosowano PCR II). Wyniki. W grupie kontrolnej Chlamydia ...

    Streszczenie angielskie: Background. The role of viral and bacterial co-infection is stressed in cervival carcinoma. A view that cervical carcinoma is a sexually transmitted disease made the area of research larger and stimulated scientists to seek other sexually transmitted factors, among which Chlamydia trachomatis and Herpes simplex are frequently examined. Purpose. The aim of the study was evaluation of frequency of occurrence of HPV-DNA and frequency of co-infection with Chlamydia trachomatis in epithelium of squamous cell cervical carcinomas, high grade dysplasis and normal cervix. Material and methods. Study group consisted of 35 patients with high grade dysplasia and 29 with squamous cell cervical carcinoma. Control group consisted of 33 healthy patients after myomectomy. In order to identify viral DNA in DNA isolated from postoperative material, PCR analysis was performed using starters complementary to various types of HPV. Results. In control group, Chlamydia trachomatis was found in 3 cases (3/33), i.e. 9.1 p.c. In 5 cases (5/29), which constituted 16.7 p.c., Chlamydia trachomatis was identified in patients with squamous cell cervical carcinoma. However, difference with the control group was not statistically significant. It was shown that frequency of occurrence of Chlamydia trachomatis was statistically significantly higher in patients with high grade dysplasia (p 0.05 p.c.) compared to control group. In CIN III group, Chlamydia trachomatis infections were found in 12 cases, ...


    2333/2523

    Tytuł oryginału: Analysis of pregnancies with a macrosomic fetus at the Department of Obstetrics and Pathology of Pregnancy in the School of Medicine in Lublin during 1997-2001.
    Autorzy: Kraczkowski Janusz J., Brzozowskiut. Ireneusz, Billewicz-Kraczkowska Aleksandra, Bednarek Wiesława, Skoczyński Mariusz, Sawulicka-Oleszczuk Henryka, Semczuk Marian
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.9-11, tab., bibliogr. 9 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: We retrospectively analyzed outcomes of with macrosomic fetus taking into consideration the following factors: maternal age and pariety, indications for cesarean delivery and fetal gender. A total of 4716 deliveries during the of 5 years study (1997-20010 were recorded at the Department of Obstetrics and Pathology of Pregnancy, School of Medicine in Lublin. Neonatal birthweight of more then 4000 g was observed 10.6 p.c. (n=500) of all deliveries. We found an increased percentage of elective cesarean section multigravidae when neonatal birthweight was 4000-4500 g. Among indications for cesarean delivery were birth asphyxia in primigravidae and multigravidae and cervical dystocia in primigravidae. We did not find any correlation between maternal parity and neonatal birthweight. A greater proportion of male neonates was noted in the study group.


    2334/2523

    Tytuł oryginału: Evaluation of perinatal management and risk of neonatal and maternal infection in preterm premature rupture of the membranes (PPROM).
    Autorzy: Semczuk-Sikora A[nna], Sawulicka-Oleszczuk H[enryka], Kwaśniewska H., Skoczyński M[ariusz], Semczuk M[arian]
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.12-17, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Premature rupture the membranes (PROM) is considered and additional risk factor for pregnancy outcome. The aim of this report to evaluate the effects of reterm PROM on perinatal management, neonatal well-beineg and risk of neonatal and maternal infection as compared to preterm pregnancy not complicated by PROM. Perinatal management and outcome were analyzed in 68 patients (74 neonates) who delivered preterm with PROM-group I, and 141 women (154 neonates) who delivered preterm without PROM-group II. Mode of delivery was not significantly different between groups. Antibiotic therapy was instituted in 31 p.c. of patients without PROM and in 90 p.c. of patients with PROM. Despite this mode of management, the incidence of infection in neonates of mothers without PROM was lower than in those of mothers with PROM (53 p.c. vs 66 p.c.). No statistical differences were observed between the groups with respect to gestational age at delivery. Despite this observation, neonates from group I had significantly lower birthweight and lower Apgar scores as compared to group II neonates. Laboratory measures of infection (WBC, CRP) were significantly higher in group II compared to group I. Preterm PROM is a significant additonal risk factor for the neonate. It appears that management standards must be proposed in order to reduce the incidence of infection in premature neonates born from PROM-complicated pregnancies.


    2335/2523

    Tytuł oryginału: Clinical analysis of cesarean section in twin preganancy.
    Autorzy: Klasa-Mazurkiewicz Dagmara
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.18-20, il., tab., bibliogr. 16 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The aim of the study was to evaluate the infications for cesarean section in twin pregnancy and to present mode of delivery according to twin presentation and complications during pregnancy. Material and methods: retrospective analysis of maternal and neonatal medical records of 317 twins delivered in the Department of Obsterics and Gynecology at the Medical University of Gdańsk from January 1988 to December 1999. In the analyzed period of time therewere 317 twin deliveries, which constiuted 1.15 p.c. of all deliveries. The mean age of women was 29.1 ń 5.9 year (from 17 to 46). Cesarean section was the method of delivery in 34.4 p.c. cases of twin pregnancy. The most common indication for cesarean delivery was abnormal wein presentation - 59.6 p.c. fetal distress syndrome - 25.5 p.c. cesarean section in anamnesis - 12.8 p.c. andinfertility treatment in anamnesis - 12.8 p.c. The optimal delivery mode for twin pregnancy is still controversial and concerned with many different factors. Early diagnosis of twin presentation help to provide the appropriate perinatal care and avoid many obstetrics complications.


    2336/2523

    Tytuł oryginału: Insulin like growth factor binding protein-1 (IGFBP-1) in vaginal discharges as a marker of premature rupture of membranes (PROM).
    Autorzy: Kłósek A., Fuchs T., Zimmer M., Woytoń J.
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.21-23, tab., bibliogr. 6 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Detecting PROM in case of immature pregnancy allows to estimate menaces for both mother and fetus as well and helps during undertaking therapeutic decisions. The purpose of this study was to estimate of clinical usefulness of commercial kit detecting PROM and based on stating presence in baginal discharges Insulin like growth factor binding protein-1 (Amni Check, Mast Diagnistica Laboratoriums-Praeparate GmbH, Germany and Actim PROM, Medix Biochemica Finland), comparing sensitivity and specificity above tests with Gramm stained vaginal secretion smears and amniotic fluid index (AFI). 140 pregnant women between 17th and 42nd weeks of pregnancy were enrolled in this study. Achieved results showed that Amni Check and Actim PROM are sensitive and specific tests detecting even small leaking of amniotic fluid and having higher snsitivity comparing with currently used method based on Gramm stained vaginal secretion smears.


    2337/2523

    Tytuł oryginału: The isoenzymatic index of lactate dehydrogenase in serum during delivery.
    Autorzy: Karmowski Andrzej, Sobiech Krzysztof A., Madej Paweł, Hac Andrzej, Karmowski Mikołaj
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.24-25, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The lactate dehydrogenase LD EC 1.1.1.27 is a tetrameric molecule in which two different polypeptides may participate as H and M subunits, creating isoenzymes occuring in serum: LD1 (H4), LD2 (H3M), LD3 (H2M2), LD4 (HM3) and LD5 (M4). The aim of this study was to recommend two pre- and post-delibery LD indexes in serum of patients and to compare the indexes in two groups: primiparae and multiparae. Authors didn't find any data about this kind of presentation of the isoenzymatic indexes of LD in the available papers. The LD actibity was determined in serum from two groups of pregnants (primiparae and multiparae, each group consisted of 10 women), just before delivery and after the 2nd stage of delivery, by use the kintic kit by BioMerieux (France) and biochemical anlysator RA-XT Technicon (USA). After the total LD activity determination as well as the electrophoretic separation of isoenzymes in serum, two indexes were recommended for the estimation of the post-delivery changes: [designe]. The statistical analysis of the results was made by the t-Student test with the significance level p 0.05. The statistical significant increase in both indexes was observed after the 2nd stage of the delivery in comparison to the pre-delivery values - K1 in primiparae (0.04 and 1.25) and in mulriparae (0.45 and 0.98) as well as - K2 in primiparae (0.19 and 0.77) and in multiparae (0.15 and 0.59). Presented isoenzumatic indexes could be incentive to further research connected with the informations about the health status, preparation to the delivery and the time necessary to the recovery.


    2338/2523

    Tytuł oryginału: Short-term storage of human umbilical cord blood haematopoietic stem cells for transplantation.
    Autorzy: Szołomicka-Kurzawa Paula, Czajka Ryszard
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.26-30, il., bibliogr. 25 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • in vitro

    Streszczenie angielskie: Umblical cord blood (UCB) is an alternative source of the haematopoietic stem cells for transplantation. In this study, an effort was made to estimate the medium volume of the collected UCB and conditions of its initial storage before isolation of haematopoietic stem cells. Additionally, the mean contents of CD34+ haematopoietic stem cells among leukocytes, lymphocytes and mononuclear cells was evaluated UCB samples were obtained during deliveries. The collected blood was stored in solutions of studied anticoagulants prepared in studied sulture media, in different time intervals and different temperature. The UCB volume as well as MNC and CD34+ cell counts were correlated with the different perinatological parameters. The concentration, viability and clonogenicity of MNCs were assessed after collection and storage in the studied conditions. The sub-population of CD34+ haematopoietic stem cells within the population of MNCs was isolated using monoclonal antibodies. The collected blood volume depends on newborn weight. Umbilical blood was best stored either in room temperature or in +4řC even for 24 hours in solution made on RPMI with heparin. CD34+ cells concentration correlated only with monomuclear cells counts. The UCB collection and its short-tem storage is a safe and simple method of haematopoietic stem cells recovery for use in transplantation.


    2339/2523

    Tytuł oryginału: The analysis of deliveries after caesarean section.
    Autorzy: Banaczek Zbigniew, Winter W., Szczepanowski L., Nowocień E.
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.31-32, tab., bibliogr. 20 poz.
    Sygnatura GBL: 306,526

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • ciąża
  • płeć żeńska
  • noworodki

    Streszczenie angielskie: The analysis comprised 146 pregnant after caesarean section, who delivered at District Specialised Hospital in Radon during the period between January 2000 and May 2001. Only the women after one caesarean section were classified to natural labour. Elective caesarean sections were performed on 64 patients (43.8 p.c. of the analysed group). The remaining 82 (56.1 p.c.) were classified to natural labour.


    2340/2523

    Tytuł oryginału: Monitoring of mechanical and electrical activity of fetal heart: determination of the FHR.
    Autorzy: Jeżewski Janusz, Horoba Krzysztof, Wróbel Janusz, Sikora Jerzy, Gacek Adam, Matonia Adam, Kupka Tomasz
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.33-39, il., bibliogr. 22 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • ciąża
  • płeć żeńska

    Streszczenie angielskie: Fetal heart rate (FHR) analysis is widely used as an assessment of fetal wellbeing. The recording of electrical activity of the fetal heart has obviously the potential to provide R-R intervals data with beat-to-beat accuracy. At present, the most common is the monitoring of mechanical activity of a fetal heart using the ultrasound Doppler method. Both in the abdominal electrocardiography (FECG) and in the Doppler ultrasound method, an estimation of the instantaneous fetal heart rate requires the advanced techniques of processing and analysis of the input signal. The Doppler signal has a complex structure, which is continuously changing due to continuous variations in the relative orientation of the ultrasound beam with respect to the fetal heart. Instead of relying only on the amplitude the autocorrelation and crosscorrelation techniques analyse the entire signals and therefore they are more accurate. However, the autocorrelation leads to decreasing the beat-to-beat variability and the crosscorrelation is more sensitive to periodic interferences. In case of the fetal indirect electrocardiography, the signal obtained contains three components: maternal electrocardiogram (MECG), fetal electrocardiogram and noise. The most important is suppression of the dominating MECG, which amplitude many times exceeds the level of the fetal electrocardiogram. Obtaining high quality FECG signal in any recordings can never be guaranteed. Despite all the above mentioned advances in signal processing, abrupt erroneous changes in fetal heart rate may occur.


    2341/2523

    Tytuł oryginału: The relationship between concentrations of cotinine in serum during labour and concentrarions of haemoglobin and erythrocyte count in the blood during pregnancy.
    Autorzy: Mańka Grzegorz, Bodzek Piotr, Tyrpień Krystyna, Wielkoszyński Tomasz, Olejek Anita
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.47-49, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • ciąża
  • płeć żeńska

    Streszczenie angielskie: The objective of the research was to determine the relationship between the haemoglobin concentrations as well as erythrocyte count in the blood of pregnant women in given trimesters of pregnancy and exposure to tobacco smoke expressed in values of cotinine concentrations in the mother blood serum during labour. The research covered 100 patients with physiological pregnancy, which ended with delivery through natural passages at term. Analyses of regression curves for relationship between haemoglobin concentrations as well as erythrocyte count and cotinine concentrations in the mother serum during labour show that when cotinin concentrations grow, the erythrocyte count and haemoglobin concentrations in the mother blood drop in the 3rd trimester.


    2342/2523

    Tytuł oryginału: Pregnancy induced hypertension (PIH) as the cause of anticipation of delivery - comparison study of computerised cardiotocograms in normal pregnancy and PIH.
    Autorzy: Kamiński Kazimierz, Cholewa Dariusz, Wnęk Małgorzata, Węgrzyn Piotr
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.50-52, tab., bibliogr. 16 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • ciąża
  • in vitro

    Streszczenie angielskie: The authors of the paper have made comparison study of selected parameters of CTG antenatal recordings using MONACO system in physiological pregnancy and PIH. Indications to earlier anticipation of delivery associated with PIH were also analysed. Low episodes and short-term variations were substantially lower in PIH than in normal pregnancy. Computerised analysis of cardiotocogram appeared to be useful method in monitoring of foetal well being in PIH and important tool in making clinical decisions.


    2343/2523

    Tytuł oryginału: Effect of amnioinfusion for meconium-stained amniotic fluid.
    Autorzy: Kamiński Kazimierz, Sławska Helena, Wnęk Małgorzata
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.53-55, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • płód

    Streszczenie angielskie: The purpose of our study was to evaluate the efficacy of prophylactic amnioinfusion in reducing perinatal complications associated with meconium-stained amniotic fluid. The labor and neonatal outcome of patients with prophylactic amnioinfusion performed over a 1-year period were compared to a control group of patients with meconium-stained amniotic fluid without amnioinfusion. The study included 112 pregnant women and their newborn, 57 in the study group and 55 in the control. Additional analysis of the newborns' condition in connection with amnioinfusion effectiveness was carried out in the study group. Thirty-five patients qualified to the effective amnioinfusion group and twenty-two to the ineffective amnioinfusion group. The cesarean sections rate and occurrence of perinatal disturbances in newborns were determined. Results were analyzed with chiý Pearson's test, chiýYates' test and chiýNW test. A p value 0,05 was considered statistically significant. There were distinct but not significant (p = 0.0553) differences between groups regarding mode of delivery. In the study group with amnioinfusion the indication for cesarean delivery was failure to progress while in the control group in more than 50 p.c. it was fetal distress. Infants delivered after amnioinfusion were in a better condition than those in the control group but only in the 5th minute of life were these differences statistically significant (p = 0.0067). There were no statistically in the neonatal outcomes regarding amnioinfusion effectiveness. Prophylactic amnioinfusion for meconium-stained amniotic fluid decreases the frequency of cesarean delivery in cases with threatened intrauterine asphyxia and contributes to improvement of neonetal condition...


    2344/2523

    Tytuł oryginału: Cord blood RANTES concentration as a predictor of intrauterine infection? - a preliminary study.
    Autorzy: Królak-Olejnik Barbara, Beck Brygida
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.56-58, tab., bibliogr. 12 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • ginekologia i położnictwo
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Chemokines constitute a large family of chemotactic cytokines that selectively attract different blood cell types. Although most inflammatory chemoattractants are only iduced and released in the circulation during acute infection, a restricted number of CźC and CC chemokines are constitutively present in normal plasma at high concentration. RANTES a member of the CC subgroup of chemokines, has proinflammatory actions, is produced by large variety of cell, including T cells, macrophages and endothelial cells. The objective of this study were to explore the relationship between labor (preterm and term) and umbilical blood serum concentration and to determine whether intrauterine infection of newborm is associated with changes in umbilical blood serum concentrations of RANTES. Umbilical blood was obtained from 67 newborns in the following groups: 1) preterm inflants with intrauterine sepsis, 2) preterm infants with intruterine pneumonia 3) preterm infants without infection and 4) full term healthy infants. RANTES concentrations were determined by use of a commercially available immunoassay kit (R&D Systems). Median RANTES cord blood concentration of full-term healthy infants was 67.8 ng/ml (range 45.2-105.0 ng/ml). Median RANTES concentrations in the umbilical cord serum preterm infants with early sepsis were 44.4 ng/m (range 27.0 - 102.5 ng/ml), preterm infants with intrauterine pneumonia - 49.5 ng/ml (range 13.9 - 64,3 ng/ml) and preterm infants without infection - 51.3 ng/ml (rang 13.9 - 91.4 ng/ml). The median cord blood plasma concentrations of RANTES i higher in full term healthy infants than in preterm ones. Intrauterine infection preterm infants is not associated with changes in RANTES concentrations in umbilical cord blood.


    2345/2523

    Tytuł oryginału: The fetus papyraceous - clinical case report.
    Autorzy: Kamiński Kazimierz, Wojdan Robert, Cholewa Dariusz
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.59-61, bibliogr. 10 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Authors present the case of trigeminal pregnancy complicated with an early death of the one of foetuses. Thorough monitoring and appropriate therapeutic procedures enabled continuation of the pregnancy till the 35th week of its duration and ending it with the delivery of two healthy foetuses. The described case of trigeminal pregnancy disturbed with death of one foetuses is an example of conservative, effective procedure in this pathology of pregnancy.


    2346/2523

    Tytuł oryginału: Monitoring of mechanical and electrical activity of fetal heart: the nature of signals.
    Autorzy: Jeżewski Janusz, Wróbel Janusz, Horoba Krzysztof, Cholewa Dariusz, Gacek Adam, Kupka Tomasz, Matonia Adam
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.40-46, il., bibliogr. 16 poz.
    Sygnatura GBL: 306,526

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • płód

    Streszczenie angielskie: At present, the heart activity is the only vital function of a fetus that can be recorded effectively. The instantaneous fetal heart rate (FHR) espressed in beats per minute is a reciprocal function of time interval calculated as the distance in time between a two successive cardiac cycles. The FHR signal can be obtained from the mechanical or electrical activity of fetal heart. Two techniques of fetal electrocardiogram fecording can be distinguished: direct - from fetal skin and indirect - from maternal abdomen. The direct access to the fetus can be made only during labour when the fetal membranes have been ruptured. The best results are obtained when the electrode penetrates the fetal presenting part - usually head. In the abdominal electrocardiography, the signal is acquired from electrodes placed on the surface of maternal abdomen. There is one major noise source that requires complex signal processing. It is an interfering electrocardiogram of the mother, magnitude of which is about 200 mV, whereas the fetal electrocardiogram is only of about 10 mV. Applying the Doppler principle of ultrasound waves aimed at the fetal heart enables monitoring of the mechanical activity of the fetal heart. Determination of instantaneous FHR relies on the detection of heart beats gased on the analysis of ultrasound beam reflected from the moving valves or walls.


    2347/2523

    Tytuł oryginału: Acute pancreatits during pregnancy - case report.
    Autorzy: Kamiński Kazimierz, Tyczyński Andrzej, Wojdan Robert, Węgrzyn Piotr
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.62-63, bibliogr. 6 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The authors report a case of acute pancreatitis in pregnancy with remarkable changes in mother's lipid metabolism. Pregnancy and hyperlipidaemia are among rare cases of acute pancreatitis. On the other hand acute inflammation of pancreas is thought to be one of most serious abdominal organ disasters. This is very serious threat to life of the mother and foetus, and demands efficient co-operation between obstetricians and surgeons in introducing both conservative and surgical treatment.


    2348/2523

    Tytuł oryginału: Successful pregnancy outcome after intravenous immunoglobulin therapy in woman with a history of four recurrent spontaneous abortions and subsequent endometriosis-associated infertility.
    Autorzy: Jerzak Małgorzata, Kraczkowski Janusz, Krzyżanowski Arkadiusz, Sawulicka-Oleszczuk Henryka, Górski Andrzej, Semczuk Marian
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.64-65, bibliogr. 17 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: The purpose of the work was to determine pregnancy outcome after a small-dose intravenous immunoglobulin (IVIG) and additional immunosupressive therapy (prednison, aspirin) in woman with an increased number of natural killer cells (NK cell) who has a history of recurrent spontaneous abortions (RSA) and endometriosis-associated infertility. Case report concerning pregnancy outcome in woman with four RSA and moderate endometriosis after immunosupression (IVIG/prednison/aspirin therapy). The following immune parameters of cellular (CD3, CD4, CD8, CD16, CD56 expressions, NK cell activity) and humoral immune response (circulating anticoagulants, anticardiolipin, anti-nuclear autoantibodies) were studied. Immunosupression therapy controlled CD16 NK cell level and NK cell activity and favored a successful pregnancy. IVIG/prednison/aspirin immunotherapy might be effective treatment for women with the history of RSA and diagnosed endometriosis. Regulation of NK cell activity may underlie possible effect of IVIG action in such cases.


    2349/2523

    Tytuł oryginału: Rare case of early diagnosed intramural pregnancy.
    Autorzy: Olejek Anita, Mańka Grzegorz, Drębkowski Aleksander, Zamłyński Jacek, Nowak Leszek
    Źródło: Arch. Perinat. Med. 2002: 8 (1) s.66-67, il., bibliogr. 12 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • radiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: We present a case of 42 years old patient with intramural pregnancy. The first diagnosis was establish according to ultrasound examination bud the ultrasound picture did not allow to differentiate in a straightforward way whether the pregnancy is located in the intramural part of the right hand side oviduct, or more typically in the ampullar part. We decided to perform the laparoscopy, and after the confirmation of diagnosis, we performed the classical supra-cervical uterus amputation. In conclusion, it seems that ultrasound examination followed possibly by laparoscopy is a sufficient method of diagnosis of intramural pregnancy.


    2350/2523

    Tytuł oryginału: Comparative evaluation of urease tests and culture used in the detection of Helicobacter pylori in gastric mucosa biopsies.
    Tytuł polski: Porównawcza ocena testów ureazowych i hodowli bakteryjnej przy wykrywaniu Helicobacter pylori w bioptatach błony śluzowej żołądka.
    Autorzy: Kafel Stanisław, Popowski Janusz, Szponar Lucjan
    Źródło: Żyw. Człow. 2002: 29 (1/2) s.21-28, tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 305,734

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Obecność Helicobacter pylori w bioptatach błony śluzowej żołądka może być wykryta za pomocą badania histopatologicznego, kultur bakteryjnych lub za pomocą szeregu dostępnych na rynku testów ureazowych. Przeprowadzono porównawczą ocenę właściwości diagnostycznych dwóch testow ureazowych ("Test Ureazowy" i CLOtest) oraz metody posiewu na podłożach bakteriologicznych. Czułość, specyficzność i praktyczne cechy użytkowe powyższych testów były oceniane w oparciu o wyniki badań diagnostycznych 100 pacjentow poddanych gastroskopii. W badaniach laboratoryjnych porównywano także czas pojawiania się barwnej reakcji w obu ureazowych testach w zależności od liczby komórek Hp oraz liczby komórek innych bakterii wytwarzających ureazę. W konkluzji, postuluje się wyższość polskiego Testu Ureazowego nad CLOtestem i metodą posiewową.

    Streszczenie angielskie: Helicobacter pylori in gastric mucosa biopsy specimens may be detected by means of several methods like histo-pathological assessment, culture on bacteriological media and urease tests. Comparative evaluation of the most popular in Poland urease tests (:Test Ureazowy" and CLOtest) and bacterial culture on solid medium has been carried out. The sensitivity, specificity and utilitarian properties of these diagnostic methods were analyzed on the ground of the results obtained after examination of biopsies taken from 100 patients referred to upper gastroscopy. The rate of color reaction in urease tests was also estimated in relation to the number of Hp cells and other urease producers introduced to reaction well. The suoperiority of the "Test Ureazowy" over CLOtests and culture is postulated in conclusion.


    2351/2523

    Tytuł oryginału: Traumatologicke Centrum Fakultni Nemocnice s poliklinikou Ostrava.
    Tytuł polski: Centrum Traumatologii Uniwersyteckiego Szpitala z Polikliniką w Ostravie.
    Autorzy: Pleva Leopold
    Źródło: Rocz. Dziec. Chir. Uraz. 2002: 6 s.40-46, il., streszcz., sum.
    Sygnatura GBL: 313,543

    Hasła klasyfikacyjne GBL:
  • pediatria
  • organizacja ochrony zdrowia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: W pracy przedstawiono główne zadania regionalnego Centrum Traumatologii w Ostravie. Powstało ono w 1991 r. na bazie Kliniki Chirurgii jako jedno z pierwszych w Czechosłowacji. Przedstawiono twórców tego ośrodka i historię powstania. Opisano struktury organizacyjne i pracujące zespoły specjalistyczne. W roku 2001 zaopatrzono ambulatoryjnie 33.867 osób, zaś hospitalizowano 1604 pajentów. W Centrum wydzielono część dla dzieci z izbą przyjęć, salami operacyjnymi i intensywnej terapii, które mają ścisły związek z Kliniką Chirurgii Dziecięcej. W roku 2001 hospitalizowano w niej 277 dzieci z powodu urazów.

    Streszczenie angielskie: The paper presents main functions of the regional Trauma Center in Ostrava. It was established in 1991 on the basis of the Surgery Clinic, as one of the first centers in Czechoslovakia. Organizers and history of that center were presented. The author described organization structures and working specialistic teams.In 2001 33.867 people were treated in ambulatory system and 1604 patients were hospitalized. The Center includes a special part for children with its own emergency room, operating and intensive care wards, which are closely connected with the Pediatric Surgery Clinic. In this Clinic 277 children with injuries were hospitalized in 2001.


    2352/2523

    Tytuł oryginału: Are multiples growth restricted?
    Autorzy: Blickstein Isaac
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.7-9, il., bibliogr. 8 poz.
    Sygnatura GBL: 306,526

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża


    2353/2523

    Tytuł oryginału: Influence of TUC (thymus ubiquitin complex) - Jelfa on the rabbit placentas' morphology in experimentally induced antiphospholipid syndrome.
    Autorzy: Parafiniuk Mirosław, Ossowicka-Stępińska Jadwiga, Ronin-Walknowska Elżbieta
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.10-15, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The aim of the study was to analyse the influence of TUC (thymus ubiquitin complex) on rabbit's placenta morphology in experimentally induced antiphospholipid syndrome. The material consisted of 80 placentas, descended from 40 pregnant rabbits on White New Zeland breed, divided into 4 groups: Group C - control - 20 placentas, descended from 10 pregnant rabbits, treated by natrium chloratum in doses and terms analogical with the others rabbits. Group I - 20 placentas, descended from 10 pregnant rabbits. immunisated by aubcutaneous cardiolipin administration (Biomed-Kraków) mixed with adjuvant (2 p.c. solution of aluminium hydroxide) in proportion 1:1, receiving since the 10th day of pregnancy, twice weekly 2250-3000 g. Group TUC - 20 placentas, descended from 10 pregnant rabbits, treated by intramuscular Thymus Ubiquitin Complex administration (Zakłady Farmaceutyczne Jelfa) on 20th, 22nd and 26th day of pregnancy 10 mg daily. Group I/TUC - 20 placentas, descended from 10 pregnant rabbits, immunisated by subcutaneous cardiolipin administration mixed with adjuvant (2 p.c. solution of aluminium hydroxide), receiving since the 10th day of pregnancy twice weekly and treated by intramuscular Thymus Ubiquitin Complex administration on 20th, 21st, 22nd and 26th day of pregnancy 10 mg daily. Pregnancies were terminated on the 30th day by means of caesarean section under general anaesthesia with Vetbutal and the material for histological study was collected. The preparations were observed in the microscope in the hundredfold enlargement...


    2354/2523

    Tytuł oryginału: Multivitamin supplementation during pregnancy and birth weight.
    Autorzy: Cadkova Ivana, Forbelska Marie, Michalek Jaroslav
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.16-20, tab., bibliogr. 33 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • farmacja
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The examined question is: doses here exist any association between multivitamin/trace elements (MV) supplement use during pregnancy and birthweight. The study was carried out on 1476 women with uncomplicated singleton pregnancy. At first the influence of various biological, social and economical factors on birthweight was tested by univariate analysis. The next variables turned out to be significant: length of pregnancy, parity, height, pre-pregnancy weight, body mass index and weight gain of the mother, sex of the child socio-economic status of the family and MV intake. Then multivariate analysis ANCOVA was made to investigate significance of MV intake's influence after adjustment for other confounding variables. The pattern and period of MV intake was distinguished (daily - irregularly - none during the first - second - third trimester). Brithweight after daily intake during the II. trimester appeared to be significantly higher (p = 0.001), during the I. trimester the significance of birthweight's increase was just below 5 p.c. border (p = 0.056), for the III. trimester there was no significance. Irregular use was not statistically analysable. Finally, partial subgroups were created according to fetal sex and socio-economic family status and in each of it the influence of MV supplementation was tested separately. The increase of birthweight in the subgroups differed. The biggest difference, even after adjustment, was in boys and girls (+130 g and +102 g, respectively) from families of the lowest socio-economic level. This increase was statstically significant. In families of the middle or high socio-economic level the increase was not significant.


    2355/2523

    Tytuł oryginału: Efficacy of recombinant activated factor VII (rFVIIa, NovoSeven**R) in prenatal medicine.
    Autorzy: Bręborowicz Grzegorz H., Sobieszczyk Sławomir, Szymankiewicz Marta
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.21-27, tab., bibliogr. 32 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • hematologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Recombinant activated factor VII (rFVIIa, NovoSeven**R) is mainly indicated for the treatment of patients with haemophilia and inhibitors in the control of bleeding. However, little (or no) information is available on the use of rFVIIa in the treatment of severe and recurrent bleeding and its complications in perinatal medicine. We report seven cases of perinatal bleeding (uterine atony, hypovolaemic shock) and its complications (DIC). In one case rFVIIa was administered as perioperative prophylactics in a pregnant women with diagnosed resistance to heparin. We used small doses of rFVIIa (16.7 - 48 ćg x kg**-1). The response to treatment was rapid, with good clinical and coagulologic control. Good stabilization of clinical parameters and decrease of bleeding within 4 h after the application of rFVII were observed. No side-effects related to rFVIIa use were noted. These cases suggests a potential role and place of NovoSeven**R in the treatment of severe and recurring bleeding complications in perinatal medicine.


    2356/2523

    Tytuł oryginału: Late-onset neonatal sepsis - diagnostic usefulness of procalcitonin, C-reactive protein and immature to total neutrophils ratio.
    Autorzy: Korczowski Bartosz, Chrząstek-Spruch Hanna, Błaszkiewicz Paweł
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.28-30, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Procalcitonin (PCT) is a new marker of severe bacterial infection. To compare the clinical usefulness of PCT, C-reactive protein (CRP) and white blood count with differential in the diagnosis of late-onset neonatal sepsis was the aim of the study. One hundred twenty nine newborns older than 3 days were included into the study and divided into 3 groups: group A - 61 newborns with sepsis; group B - 46 babies with local infections, group C - 22 newborns with severe distress but no infection. For comparison 30 healthy controls older 3 days were enrolled into the study - group D. Determinations of CRP concentration and PCT and white blood count with differential were performed on admission or at the moment when previously stable condition of the newborn deteriorated. Sensitivity, specificity, negative and positive predictive values for two different cut-off points for each parameter were calculated. At a cut-off value of 0.5 ng/ml for PCT and 0.5 mg/dl for CRP these parameters detected septic newborns with a sensitivity of 97 p.c. and 49 p.c. and specificity of 75 p.c. and 60 p.c. If cut-off points of 1.0 ng/ml and 1.0 mg/dl were used. PCT also had higher sensitivity (85 p.c.) and specificity (91 p.c.) than CRP (sensitivity - 38 p.c., specificity - 85 p.c.). I/T ratio 0.2 was specific for sepsis (100 p.c.) but low sensitivity (12 p.c.) limits it's usefulness. I/T ratio achieved better sensitivity (49 p.c.) but it's specificity dropped to 88 p.c. PCT comparing to CRP and I/T ratio is more reliable marker in the diagnosis of late-onset neonatal sepsis.


    2357/2523

    Tytuł oryginału: Comparative evaluation of the effects of continuous and multiple infusions of indomethacin therapy for patent ductus arteriosus closure in preterm infants.
    Autorzy: Strzałko-Głoskowska Barbara, Maroszyńska Iwona, Wilczyńska Małgorzata, Makowiecka Elżbieta, Sysa Andrzej, Nowak Stanisław, Gadzinowski Janusz
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.31-33, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Cerebral blood flow (CBF) velocity wa assessed during 30 minutes multiple and continuous (36 hours) infusion of indomethacin in 39 premature neonates. The rapid infusion was associated with a significant reduction in blood flow velocity in the right middle cerebral artery (MCA). These changes were not observed in the group treated with continuous infusion, but the method reduced significant efficacy of closing the PDA. Indomethacin remains a useful and effective treatment for PDA in preterm infants, but should continue to be used with caution as we found that administration by 30 minutes infusion does produce haemodynamic alterations to the cerebral circulation.


    2358/2523

    Tytuł oryginału: Does coagulation factor V Leiden mutation predispose to PIH?
    Autorzy: Seremak-Mrozikiewicz Agnieszka, Mrozikiewicz Przemysław M., Drews Krzysztof
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.34-35, tab., bibliogr. 14 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • kardiologia
  • hematologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The disturbances in intravascular coagulation were shown to be strong involved in the pathogenesis of pregnancy-induced hypertension (PIH), and candidate genes examined to display a role in pathophysiological effects of PIH are the genes coding for coagulation pathways. The purpose of this study was to determine the frequency of factor V Leiden mutation in the group of women with gestational hypertension. We have detected the slight overrepresentation of genotypes carrying at least one mutated factor V allele in the PIH group, so we have concluded that the presence of the Leiden mutation could be involved in the pathogenesis of PIH.


    2359/2523

    Tytuł oryginału: Chronic lung disease of newborns - the incidence and the risk factors according to the criteria of diagnosis.
    Autorzy: Wróblewska-Seniuk Katarzyna, Szczapa Jerzy, Kawczyńska Natalia, Szymańska Karolina, Szymańska Dorota, Gadzinowski Janusz
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.36-39, tab., bibliogr. 8 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Objective: To assess the incidence, risk factors and complications of the chronic lung disease (CLD) according to diagnostic criteria. Design: Retrospective study. Patients: 126 newborns with oxygen dependency at 28 days of age but not at 36 weeks PMA (group I) and 86 newborns requiring oxygen therapy at both 28 days of age and 36 weeks PMA (group II). All infants were born between 01.01.1997 and 31.12.2001 and treated at the Department of Neonatology at The University of Medical Sciences in Poznań. Results: In both groups the major part were preterm infants and newborns with very low birth weight. CLD was most frequent in newborns born between 25th and 27th week of gestational age and with birth weight 750-999 g. The incidence of CLD at 28 days of age was higher than of CLD at 36 weeks PMA, with the exception of newborns born before the end of the 24th week of gestational age and with birth weight 750 g. Infants with CLD at 36 weeks PMA had lower birth weight, more often suffered from pneumothorax and mycotic infections. The incidence of other risk factors was similar in both groups. Complications were more frequent in the group II. 6 children from the first group and 12 from the second group died before discharge from hospital (4.8 vs. 14 p.c., p 0.05). Conclusion: The incidence of CLD depends on the diagnostic criteria and is lower if diagnosed at 36 weeks PMA. The most important factors influencing the development of CLD seem to be prematurity and extremely low birth weight.


    2360/2523

    Tytuł oryginału: Pregnancies after chemotherapy of gestational trophoblastic disease.
    Autorzy: Nowak-Markwitz Ewa, Magnowski Piotr, Spaczyński Marek
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.40-42, tab., bibliogr. 18 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The reproductive performance of 48 women successfully with chemotherapy in Gynecologic Oncology Department between 1980-2000 because of gestational trophoblastic disease was analyzed. Among 19 nulliparous were conceiving 18 (95 p.c.), among 29 multiparous conceived 12 (41 p.c.), 11 (38 p.c.) women applying contraceptives and the sterility was recognized in 6 (21 p.c.). We compared also the fertility depending on cytostatic drug combination received during treatment. Results show, that neither type of chomptherapy (single agent or multi agent) nor the duration of treatment not have any importance in further pregnancies and child condition. We have not observed any malformations in children. Also the abortion ratio in our patients was low. Our 30 women have had 48 pregnancies with 41 (86 p.c.) live full term delivery, 4 (8 p.c.) spontaneous abortion, 2 (4 p.c.) repeated hydatidiform moles and 1 (2 p.c.) stillbirth.


    2361/2523

    Tytuł oryginału: Increase in the inspiratory and expiratory volume in newborns treated with mechanical ventilation and budesonide.
    Autorzy: Haglauer Monika, Szymankiewicz Marta, Gadzinowski Janusz, Kamieniarz Grzegorz
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.43-49, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: The aim of the study was to determine the effect of inhalatory administration of budesonide on two pulmonary function measurements (PFM): inspiratory volume (TVinsp) and expiratory volume (TVexp) of mechanical and spontaneous breaths in newborns treated with mechanical ventilation. The subjects were 10 newborns of the mean birth weight of 950 g (ranging from 750 to 1460 g) and mean maturity of 26.6 weeks (ranging from 25 to 28 weeks). Pulmonary function measurements (PFM) were performed by using a respiratory mechanics monitoring system VenTrak**R, before and 5 minutes after administration of inhaled budesonide. The results proved a significant increase in the inspiratory volume in mechanical breaths and in expiratory volume for mechanical and spontaneous breaths. The improvement of these parameters testifies to a beneficial short-term effect of the inhaled steroid. An increase in the inspiratory volume of spontaneous breath was also observed but the difference was not statistically significant, so it cannot be concluded that this parameter has changed as a result of budesonide administration.


    2362/2523

    Tytuł oryginału: Changes in glycated haemoglobin (HbA1C) level and daily insulin dosage during pregnancy in women with pre-existing diabetes mellitus (PGDM).
    Autorzy: Zawiejska Agnieszka, Wender-Ożegowska Ewa, Pietryga Marek, Biegańska Ewa, Mitkowska Hanna, Meissner Wioletta, Meller Sławomir, Biczysko Romuald
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.50-53, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Diabetes mellitus coexisting with pregnancy constitutes a higher perinatal risk, apart from an improvement in perinatal care made during last years. Pregnant women with pre-existing DM (PGDM) develop many obstetric complications more often than healthy gravides. To prevent from the adverse perinatal outcome, tightly corrected glucose blood level, intensive insulin therapy and continuous monitoring of therapy are required. The aim of the study was to find out whether a more often assessment of HbA1C level can be helpful when monitoring changes in this parameter and useful for a purpose of following a glycemia correction. A dynamics of changes in HbA1C level during pregnancy in women with PGDM was also evaluated relating to a stage of the disease. Our group consisted of patients hospitalise d in the Department of Obstetrics and Maternal Disease of Karol Marcinkowski University of Medical Sciences in Poznań between 1999-2001. The study covered 64 gravidas suffering from PGDM at different stages, according to a Priscilla White's classificaion: class B - 23 patients (35,9 p.c.), class C - 23 patients (35,9 p.c.), class D - 7 patients (11 p.c.), class R-F - 11 patients (17.2 p.c.). The average initial HbA1C level was: 7.3 ń 2.1 p.c., 6,5 ń 1.8 p.c., 7.1 ń 1.4 p.c. and 7.5 ń 1.5 p.c., in the moment of delivery average level of HbA1C was: 6.8 ń 1.3 p.c., 6.0 ń 1.2 p.c., 5.8 ń 1.5 p.c., 5.5 ń 1.5 p.c., respectively. All patients were treated with intensive insulin therapy (NovoNordisk**R, Eli Lilly**R). Every gravida underwent a special training for diabetics...


    2363/2523

    Tytuł oryginału: Brain death in newborns and infants - proposal of diagnosis and management - review of literature.
    Autorzy: Piaszczyński Maciej, Anttila Vesa, Wojtalik Michał, Gadzinowski Janusz
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.54-57, bibliogr. 15 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta

    Streszczenie angielskie: The aim of this paper was presenting the state of art regarding criteria of brain death in newborns. Definition, diagnosis and methods of confirmation of brain death were analysed, based on review of literature. The management with anencephaly newborn was proposed.


    2364/2523

    Tytuł oryginału: Isolated vein of Galen aneurysmal malformation (VGAM) in a neonate.
    Autorzy: Szymankiewicz Marta, Uchman Jolanta, Chmielnicka-Kopaczyk Maria, Małecki Andrzej
    Źródło: Arch. Perinat. Med. 2002: 8 (2) s.58-60, il., bibliogr. 6 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • ginekologia i położnictwo
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska

    Streszczenie angielskie: We present a case of the 35-weeks female newborn with critically severe form of cardiovascular insufficiency coexisting with disseminated intravascular coagulation syndrome due to postnataly diagnosed aneurysm of a vein of Galen. Two-dimensional color power Doppler was critical in postnatal diagnosis of anomaly. The rupture of VGAM became a cause of death of a patient at 48 hours of life without any changes for an interventional therapy. Autopsy exam confirmed the diagnosis of rupture of VGAM with periventricular leukomalacia, cortex infraction and atrophy. No other congenital defects were recognized.


    2365/2523

    Tytuł oryginału: Triplet pregnancies and their aftermaths. [P.] 1: Basic considerations.
    Autorzy: Keith Louis, Bręborowicz Grzegorz H.
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.7-13, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The medical community presently faces the "epidemic" of multiple pregnancies, the majority of which are not the result of spontaneous conceptions. "Iatrogenic" multiple pregnancies are at high risk for infants and mothers and place considerable burden on the healthcare system.


    2366/2523

    Tytuł oryginału: Triplet pregnancies and their aftermaths. [P.] 2: Risks of older mothers and plurality.
    Autorzy: Keith Louis, Bręborowicz Grzegorz H.
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.14-18, bibliogr. 26 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: There is no literature that accurately reports the risks inherent to the woman over age 40 who carries a triplet pregnancy. Extrapolating the singleton literature does not provide solid evidence, as risks are described variously by different authors and may relate to maternal age or parity as independent factors, which affect both maternal and fetal outcome data. On the other hand, recent population-based surveys strongly suggest that plurality is a more important risk factor than maternal age, as it affects both maternal and fetal outcomes.


    2367/2523

    Tytuł oryginału: Incidences of peri-intraventricular hemorrhages among ifnants born or transported to Department of Neonatology at University of Medical Sciences in Poznań in years 1997-2000.
    Autorzy: Czarnecka-Porzucek Iwona, Gadzinowski Janusz, Szymankiewicz Marta, Budzyńska Katarzyna, Kachlicki Filip
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.19-22, tab., bibliogr. 26 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Peri-intraventricular hemorrhages (PIVH) might affect high rates of neonatal morbidity and mortality. There are multiple risk factors of PIVH, i.e. prematurity, low birth weight, mechanical ventilation. The aim of study was to analyse retrospectively of incidneces of PIVH among 669 infants attended to Department of Neonatology at University of Medical Sciences in Poznań between 1997-2000. The patients were divided depending on the severity of PIVH (according to Papile classification). We did observe the common tendency to decrease incidences of the mild PIVH as well as the severe one. We did find the major factors affected incidence and severit of PIVH such as birth weight 1500 g, prematurity, presence of hypoxia and poor condition after delivery (low Apgar score), prolonged mechanical ventilation, transportation between hospitals of 1st nd 3rd level of perinatal care. We did confirm the statistically higher percentage of ortality among infants, who underwent severe PIVH.


    2368/2523

    Tytuł oryginału: Congenital malformations in neonates of mothers with epilepsy.
    Autorzy: Kociszewska Iwona, Zięba Krzysztof, Pawłowska Barbara, Wilczyński Jan, Gadzinowski Janusz
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.23-27, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The aim of the study was to estimate the incidence of congenital malformations in neonates of healthy mothers and suffered from epilepsy. There were analysed different kinds of pathologies that were present in investigated group of children and maternal risk factors that could have an influence on congenital malformations appearance. The analysis was held in Polish Mother's Memorial Research Institute in Łódź in years 1990-1998. The investigated group included 211 neonates of epileptic mothers. Control group included 211 healthy neonates randomly enrolled into study. Congenital malformations were diagnosed based on ultrasonographic examination, clinical examination after birth, echocardiography, transcranial ultrasonography, abdominal ultrasonography, CT and NMR. Epilepsy and its treatment increases the risk of congenital malformations. Congenital malformations appear three times more frquently in women with epilepsy. Congenital hearth disease, lips and palate clefts were most commonly observed. Increased incidence of epileptic seizures during pregnancy and antiepileptic treatment with phenytoin and valproic acid increased significantly the risk of congenital malformation in neonate. Early and complex prenatal care of epileptic mothers and folic acid supplementation make the risk of congenital malformations in neonates lower.


    2369/2523

    Tytuł oryginału: Diagnostic vlaue of transvaginal colour and pulsed Doppler in ectopic pregnancy.
    Autorzy: Bakon Igor, Sikora Jerzy, Kapek Tadeusz, Machalski Tomasz, Chromy Grzegorz, Nawrocki Michał
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.28-30, bibliogr. 18 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • radiologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The objective of the study was to evaluate the diagnostic value of transvaginal colour and pulsed Doppler in the diagnosing of ectopic pregnancy. 53 women suspected of ectopic pregnancy were subjected to transvaginal ultrasonography with the use of colour and pulsed Doppler. An image of appendage vascularisation was obtained in all patients using the colour Doppler; pulse Doppler served to calculate the resistance index (RI), pulsation index (PI) and systolic/diastolic index (S/D) for blood circulation in the ovarian and tubal vessles in all patients. During laparoscopy, ectopic pregnancy was confirmed in 25 out of 53 women (47.2 p.c.). In each case of tubal pregnancy colour Doppler examination revealed a more intensive vascularisation of the oviduct in which the foetal ovum was implanted. The pulse Doppler examination revealed values of RI which were lower by 63 p.c. on the average, and S/D values lower by 56 p.c. on the average in the oviduct arterial vessels on the side of the ectopic pregnancy than on the opposite side.


    2370/2523

    Tytuł oryginału: Premature labour risk in pregnant women with bacterial vaginosis infection.
    Autorzy: Kozak-Darmas Iwona, Bodzek Piotr, Grettka Krzysztof, Olejek Anita, Nowak Leszek
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.31-32, tab., bibliogr. 12 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • choroby zakaźne
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The most often diagnosed vaginal infection is bacterial vaginosis (BV). The objective of the research was to analyse risk and occurrences of premature labour in the case of pregnant women with the BV infection. BV is an important factor of the risk of premature labour occurrence. BV treatment during pregnancy might contribute to preventing and decreasing of the percentage of premature labours and to lowering the cost of hospitalisation.


    2371/2523

    Tytuł oryginału: Cesarean section delivery - is it a safe "option"?
    Autorzy: Grisaru-Granovsky Sorina, Samueloff Arnon
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.33-36, tab., bibliogr. 23 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Aim: (A). To delineate the trends in primary cesarean birth rates at our center and in the industrialized countries. (B) To summarize our experience with specific immediate and long term risks of repeat cesarean birth. Design: Shaare Zedek Medical Center perinatal database and national reports of primary cesarean birth rates (Israel, Europe and USA). Our center's experience (1990-2001) with the immediate and long-term risks of repeat cesarean: intensive care unit admissions, massive transfusion and peripartum hysterectomy. Descriptive statistics and comparisons with student t test, Mann Whitney's when appropriate and Pearson's corelation coefficient. Logistic regression model built for the significant risk factors; p 0.05 considered significant. Results: (A). Cesarean delivery rate has reached 16.3.0 p.c. in Israel and 19 p.c. in the UK. Shaare Zedek Medical Center has maintained a stable cesarean rate of 9.7 p.c. Southern Ireland is the only country in western Europe that reports a stable cesarean delivery rate of 9 p.c. In the USA between 1989-1996, cesarean rate declined by 8 p.c. (from 22.8 p.c. to 20.7 p.c.) after which a continuous rise occurred to 22.9 p.c. Despite the rising trend of cesarean delivery there has been no improvement in maternal and perinatal mortality. (B). From 61,682 deliveries, we identified 48 admissions to the intensive care unit (ICU) (0.8:1000 live births): 34 (71 p.c.) were due to obstetrical complications; 94 p.c. of the patients admitted to the ICU had had at least one previous cesarean section; more than two thirds (70.6 p.c.) that had had a cesarean delivery in the index pregnancy required additional attention...


    2372/2523

    Tytuł oryginału: Efficacy of tracheo-bronchial tree lavage with natural surfactant solution together with nitric oxide inhalation in treatment of meconium aspiration syndrome.
    Autorzy: Kowalska Katarzyna, Gadzinowski Janusz, Szymankiewicz Marta, Sierzputowska Monika
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.37-41, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: An aim of study was to evaluate an efficiacy of associated treatment: tracheobronchial tree lavage with natural surfactant solution (SLL) together with nitric Oxide inhalation (INO) in therapy of severe meconium aspiration syndrome (MAS) with persistent pulmonary hypertension (PPHN). Analysed material consisted of 11 neonates: group A (n = 6) - treated with SLL and INO, group B - control (n = 5) - treated with INO. Criteria of inclusion: maturity 35 weeks of gestation, presence of fluid containing meconium below vocal cords, respiratory insufficiency demanding mechanical ventilation (FiO2 4.0), radiological changes, echocardiographic features of pulmonary hypertension. Criteria of including into groups - time after delivery less than 6 hours. Method. SLL was performed with natural surfactant solution (Survanta) in concentration of 5 mg of phospholipids (1 ml 0.9 p.c. NaCl, a dose of 15 ml of solution per 1 kg). Initial NO dose was 20 ppm. Analysed parameters: IO, PaO2, (before treatmetn and after 1, 4, 12, 24 hrs), mean pulmonary artery pressure (before treatment and after 24 hrs), IMV and hospitalization times, number of deaths. Results. In group A (mean values ń SD) before treatment, IO - 24.3 (7.37), PaO2 - 50.4 mm Hg (14.0), FiO2 - 0.95 (0.1); after 1 h: IO - 8.3 (3.9), PaO2 - 117.6 mm Hg (44.5), FiO2 - 0.73 (0.2); after 24 h: IO - 4.6 (2.3), PaO2 - 75.5 mm Hg (17.7), FiO2 - 0.53 (0.24); IMV time - 4.8 ń 2.8 days; hospitalizaiton time - 12 ń 8.7 days. No death occured. In group B (mean values ń SD); before treatment: IO - 29.1 (7.6), PaO2 - 46.8 mm Hg (13.7),...


    2373/2523

    Tytuł oryginału: Interrelations of veins and arterias on the fetal surface of human placenta. Anatomical conditions of good blood perfusion of blood capillaries in placental villi.
    Autorzy: Oszukowski Piotr
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.42-44, il., bibliogr. 9 poz.
    Sygnatura GBL: 306,526

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płód
  • in vitro

    Streszczenie angielskie: Proper filling of blood capillaries of placental villi with blood may be of crucial importance for creating a spacious area for placental exchange. The author of this paper implies that a regulator of the blood pressure in the villous capillaries, which is such an important factor in the maintenance of good capillary perfusion, are probably the fetal crossing of veins and arteries, i.e. the blood vessels running on the placenta's fetal surface.


    2374/2523

    Tytuł oryginału: Animal model for open fetal surgery. Study of fetal wound healing.
    Autorzy: Kamiński Kazimierz, Łagan Jerzy, Stojko Artur, Ścigała Piotr, Ziółkowski Adam, Cholewa Dariusz, Węgrzyn Piotr
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.45-50, il., tab., bibliogr. 28 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • zarodki
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The authors present the animal model for open fetal surgery as a first step in preparing human open fetal surgery. The second purpose of the study was investigation of fetal cutaneous wound healing. Six time-dated pregnant ewes (110-120 day's gestation) underwent general anesthesia. Then after laparotomy, histerotomy was performed to prepare diaphragmatic hernia in the fetus. During the second histerotomy surgical practise in repair of diaphragmatic hernia was performed. This paper deals with the problems of monitoring fetuses during operation, preventing premature labour and methods of opening and closing the womb. Specimens of healing tissues were histologicaly investigated to compare the manner of fetal and adult wound repair.


    2375/2523

    Tytuł oryginału: Epdiemiology of the central nervous system defects of the fetus in the Pomeranian region in 1998.
    Autorzy: Świątkowska-Freund Małgorzata, Preis Krzysztof, Ciach Katarzyna
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.51-53, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • neurologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Authors present the incidence of the central nervous system defects in parts of the Pomeranian region and the analysis of its incidence fluctuation. All CNS malformations submitted to the Polish Registry of Foetal Malformations in 1998 originated in the Pomeranian region were analysed. There wer 63 malformations noted. The seasonal appearance of CNS malformations was not proved however the higher incidence was detected in pregnancies beginning in March and April. The incidence of the CNS defects was found significantly higher in greater cities and in sub-regions related to sulphuric and phosphoric industry. Conclusions: 1) The CNS defects incidence is not related to the patients' age. 2) Pregnancies with the CNS defects are ended significantly earlier. 3) The mean incidence of the CNS defets in the Pomeranian region is comparable to that of the whole population. 4) The higher incidence of the CNS malformations was detected in the greater cities and in sub-regions related close to the sulpuric and phosphoric industry. 5) The seasonal appearance of the CNS defects was not proved however they occurred more frequently in pregnancies beginning in March and April.


    2376/2523

    Tytuł oryginału: Clinical analysis of extremely low birth weight (ELBW) preterm infants treated surgically for acute abdomen symptoms.
    Autorzy: Matuszczak-Wleklak Marzena, Szymankiewicz Marta, Błaszczyński Michał, Wojsyk-Banaszak Irena, Gadzinowski Janusz, Jankowski Andrzej
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.54-57, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Advances in neonatal intensive care result in improved survival rates among extremely low birth weight (ELBW 1000 g) infants. Concomitantly however, number of severe complications that require interdisciplinary treatment increase in this patient group. In the Department of Neonatology of University of Medical Sciences in Poznań, in 5 month period from January till May 2002, 11 extremely immature neonates were treated surgically because of acute abdomen symptoms. Mean gestational age of the population studied was 26 ń 1.7 weeks, and mean birth weight was 761.8 ń 98.6 grams. Intraoperatively diagnosis of advanced necrotising enterocolitis was established in 6 newborns, mechanical obstruction was diagnosed in 2, one neonate had congenital intestinal atresia, and in two children abdominal cause of deteriotation was excluded. In 3 infants operated upon for necrotizing enterocolitis end ileostomy was made, and in the other 3 primary end-to-end anastomosis. In both neonates with intestinal obstruction caused by stool masses decompresing intestinal anastomosis were performed. We analysed the influence of various factors on the incidence and clinical course of abdominal pathology in ELBW preterm babies.


    2377/2523

    Tytuł oryginału: Pregnancy, delivery and puerperium in a 25 year old woman with surgically corrected congenital transposition of great arteries under the Rashkind and Mustard procedure. Caser report.
    Autorzy: Ziętek Jerzy, Rokicki Władysław, Sikora Jerzy, Włoch Agata, Chromy Grzegorz, Bakon Igor
    Źródło: Arch. Perinat. Med. 2002: 8 (3) s.58-62, tab., bibliogr. 27 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • chirurgia
  • ginekologia i położnictwo
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki
  • dorośli 19-44 r.ż.
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: The paper presents a very rare case of pregnancy in a 25 year old woman who in her childhood underwent Transposition of Great Arteries surgery (TGA) under the Mustard procedure, preceded by balloon septostomy (opening in the interatiral septum for better mixing of arterial and venous blood, to prevent the effect of closing of Botall's duct and to allow the survival of such patients) under the Rashkind procedure. It is a rare case of such pregnancy being brought successfully to term and of delivering a healthy neonate by a women with this type of circulatory disorder. The correct interdisciplinary cooperation between cardiologists and obstetricians allowed the pregnancy to be brought to the 38th week, maintaining optimum hemodynamic conditions in the pregnant patient. A pregnancy marked with such high risk requires scrupulous monitoring of the mother's circulatory system and of the condition of the foetus.


    2378/2523

    Tytuł oryginału: Studies on angiogenesis in the benign and malignant ovarian neoplasms with the use of color and pulsed Doppler sonography and serum CA-125, CA-19.9, CA-72.4 and vascular endothelial growth factor measurements.
    Tytuł polski: Badania nad angiogenezą w łagodnych i złośliwych guzach jajnika przy zastosowaniu ultrasonografii z kolorowym Dopplerem oraz oceny stężeń śródbłonkowego czynnika wzrostu i wybranych markerów nowotworowych: CA-125, CA-19.9, CA-72.4 i VEGF.
    Autorzy: Czekierdowski Artur
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.113-131, il., tab., bibliogr. 32 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • endokrynologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Celem pracy było zbadanie, czy zastosowanie techniki kolorowego kodowania przepływu w ocenie angiogenezy jest przydatne w różnicowaniu charakteru guzów jajnika oraz sprawdzenie czy kombinacja dwóch lub więcej z wymienionych parametrów: wieku pacjentki, badania ultrasonograficznego sondą dopochwową z kolorowym Dopplerem oraz oceny stężenia CA-125, CA-19.9, CA-72.4 i VEGF może podwyższyć wartości pojedycznego testu stosowanego w różnicowaniu łagodnych i złośliwych guzów przydatków macicy. Grupę badaną stanowiło 4876 kobiet z regionu lubelskiego, a do analizy zakwalifikowano ostatecznie 451 pacjentek z potwierdzonymi w USG guzami przdatków macicy. Analizowano wiek, status menopauzalny, maksymalny rozmiar i objętość guza oraz PI, RI, PSV i wartości cechy KOLOR. Badano stężenia antygenó CA-125, CA-19.9 i CA-72.4 oraz VEGF jako potencjalny makrer neoangiogenezy. W przeprowadzonych obliczeniach zmiany czułości i swoistosci testów przy zmianach wartości granicznej przedstawiono w formie krzywych ROC (GraphROC, Turku, Finlandia). W celu oceny, czy i które z badanych parametrów (zmienne niezależne) mają istotny statystycznie wplyw na prawdopodobieństwo istnienia nowotworu złośliwego lub łagodnego (zmienne zależne), zastosowano analizę regresji wielokrotnej. W badanej grupie wśród 451 kobiet w wieku od 13 do 76 lat (średnia 39 lat, mediana 38 lat) były 404 kobiety z łagodnymi guzami przydatkowymi oraz 47 kobiet z nowotworami złośliwymi. Odsetek pacjentek po menopauzie w grupie ...

    Streszczenie angielskie: The aim of the study was to investigate whether a combination of serum CA-125, CA-72.4; CA-19.9 and VEGF levels along with several currently used gray-scale criteria and pulsed and semigquantitative color Doppler blood flow assessment can be useful in preoperative discirmination of ovarian tumors. Ultrasound examinations were performed between 1994 and 1999 with the use of transvaginal probes 5-6.5-7.0 MHz and transabdominal 3.5 MHz probe (B&K Medical 3535 and 2002 ADI, Denmark). Preoperative serum CA-125 and CA-19.9 (Roche, Switzerland) and CA-72.4 (Centocor, USA) were measured with EIA II immunoassays. VEGF (R&D Systems, USA) serum levels were measured by microplate immunoenzymatic method. Retrospective study included 4,876 women referred for sonography of pelvic structures. For final analysis 451 patietns with persistent adnexal tumors were available. In all these women age, menopausal status, tumor size, volume and morphology as well as blood flow indices (PI, RI, PSV) and semiquantitative color assessment were noted. In women who were not operated the cysts were followed for 10-12 weeks until resolution which was confirmed by repeated sonography. Multiple regression analysis was used to determine which of the independent variables had prognostic significance in the constructed predictive model. ROC curves were plotted and areas under ROC for each test wre calcuated and compared. 286 women were operated and in 118 patients their tumors regressed. The sensitivity ...


    2379/2523

    Tytuł oryginału: Influence of time period of cadmium intoxication on the concentrations of ascorbic acid selenium in certain tissues and blood serum of rats.
    Tytuł polski: Wpływ czasu intoksykacji kadmem na stężenie witaminy C i selenu w wybranych tkankach i surowicy szczurów.
    Autorzy: Pasternak Kazimierz, Bielak Ewa
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.132-137, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Kwas askorbinowy i selen spełniają ważną rolę jako antyoksydanty w unieczynnianiu reaktywnych form tlenu. Celem przeprowadzonych doświadczeń było wykazanie wpływu różnych stężeń kadmu na stężenie kwasu askorbinowego i selenu w wybranych tkankach szczuró . uzyskane wyniki wykazały, że kadm podawany w pożywieniu wpływał na stężenie kwasu askorbinowego w surowicy krwi i badanych tkankach szczurów. Kadm wpływał również na tkankowe stężenie selenu w wybranych tkankach. Stężenie kwasu askorbinowego i selenu zależały od rodzaju badanej tkanki, jak ró neiż od stężenia podawanego kadmu oraz czasu intoksykacji.

    Streszczenie angielskie: Ascorbic acid and selenium are important antioxidants for the reactive forms of oxygen. The purpose of these experimetns was to determine the influence of various concentrations of cadmium on ascorbic acid and selenium concentrations in certain tissues of rats. The results showed that cadmium, added to rats' feed, influenced the concentration of ascorbic acid in blood serum and tested rats' tissues. Cadmium influenced the concentration of selenium in certain tissues as well. Furthermore, it has been demonstrated that ascorbic acid and selenium concentrations are dependent on the type of tissue tested as well as on the size of cadmium concentrations and length of the experiments.


    2380/2523

    Tytuł oryginału: The influence of zinc and copper supplemenation in feed on the concentrations of certain metals in rats' skin.
    Tytuł polski: Wpływ podawania cynku i miedzi w pożywieniu na stężenie niektórych metali w skórze szczurów.
    Autorzy: Pasternak Kazimierz, Bielak Ewa, Bulikowski Włodzimierz, Lingas Wiesław
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.138-142, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Cynk i miedź dostarcane do organizmu w nadmiarze mogą również wpływać na stężenia innych pierwiastków, a wtórnie i procesów przez nie regulowanych. Celem eksperymentu było określenie wpływu podawania cynku i miedzi w pożywieniu na stężenie magnezu, wapnia, cynku i miedzi w skórze szczurów. Przeprowadzone badania wykazały, że podawanie cynku powodowało spadek stężenia wapnia oraz wzrost stężenia cynku w badanym materiale. Stężenie magnezu i miedzi zmieniało się tylko nieznacznie. Podawanie miedzi powodowało zmniejszenie stężenia magnezu, wapnia i cynku, natomiast następował wzrost stężenia miedzi. Zmiany w stężeniach badanych metali były zależne od stężenia metalu podawanego szczurom w pożywieniu.

    Streszczenie angielskie: Zinc and copper, administered to the organism in excess can also influence the concentrations of other elements, and have a secondary influence on the processes that these elements regulate. The purpose of this experiment was to determine the influence of zinc and copper dietary supplementation on the concentrations of magnesium, calcium, zinc and copper in the rat's skin. The results showed that zinc supplementation caused a decrease in calcium concnetration as well as an increase in zinc concentration in the tested materials. The concentrations of magnesium and copper changed insignificantly. Copper supplementation cuased a decrease in the concentration of magnesium, calcium and zinc but caused an increase in copper concentration. Changes in concentrations of the tested metals were dependent upon the concentrations of various metals added to the rat's diets.


    2381/2523

    Tytuł oryginału: Blockade of reticular formation activity, due to carisoprodol maternal administration, and its effects on rat skeleton development.
    Tytuł polski: Blokada aktywności tworu siatkowatego po podaniu matce carisoprodolu oraz jego wpływ na rozwój szkieletu szczura.
    Autorzy: Blicharski Tomasz, Burdan Franciszek, Małkiewicz Jarosław, Piechota Grzegorz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.143-149, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • ciąża

    Streszczenie polskie: Celem eksperymentu była ocena wpływu blokady tworu siatkowatego po podaniu matce carisoprodolu oraz przebadanie wpływu na rozwój szkieletu kostnego. Lek był podawany trzy razy dziennie sondą dożołądkową w dawkach: T1 - 20 mg/kg/24h, T2 - 200 mg/kg/24h, T3 - 400 mg/kg/24h. W 21 dniu ciąży cesarskim cięciem wydobywano płody. Dokonano analizy makroskopowej. Płody i łożyska ważono. Mierzono długość płodu i ogona. Utrwalone w 95 proc. alkoholu preparaty barwiono alizaryną metodą Dawsona. Oceny dokonano przy użyciu mikroskopu świetlnego. Nie wykryto znaczącego wzrostu występownaia malformacji w porównaniu z kontrolą. Doświadczenie wykazało, że carisoprodol nie wpływa na rozwój szkieletu kostnego szczura.

    Streszczenie angielskie: The purpose of this experiment was to study the influence of reticular formation blockade, due to carisoprodol maternal administration, on rat skeleton development. The drug was administered three times a day orally by stomach tube at doses: T1 - 20 mg/kg/24h, T2 - 200 mg/kg/24h, T3 - 400 mg/kg/24h. The fetuses obtained on 21st day of gestation were counted and macroscopically examined. Placental and fetal weight, fetal and tail length were checked. After fixation in 95 p.c. ethanol the fetuses were stained under single alizarin red S Dawson method and examined under a stereo-dissection microscope. Morphological examination revealed no major malformations. Insignificant number of subcutaneous ecchymose and various skeleton anomalies were observed. The experiment revealed that carisoprodol has no influence on rat skeleton development.


    2382/2523

    Tytuł oryginału: Desmopressin - a nontransfusional form of prevention of postextractive bleeding in some patietns with von Willebrand's type I disease. Case report.
    Tytuł polski: Dezmopresyna - nietransfuzyjna metoda zapobiegania krwawieniom poekstrakcyjnym u osób z chorobą von Willebranda typu I. Opis przypadku.
    Autorzy: Rahnama Mansur, Tomaszewski Tomasz, Świątkowski Wojciech
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.150-153, bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • hematologia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie polskie: W pracy przedstawiono możliwości zastosowania preparatu Minirin (dezmopresyny) w chirurgii szczękowo-twarzowej u osób ze skazami krwotocznymi. Przypadek własny pacjenta z chorobą von Willebranda typu I potwierdza skuteczność leku w przypadku krwawień poekstrakcyjnych.

    Streszczenie angielskie: In this article the possiblity of usig the Minirin (desmopressin) in maxillofacical surgery in person with hemostatic disorders has been described. The our case of patient with von Willebrand's disease type I indicates that this drug is very effective in bleeding after teeth extractions.


    2383/2523

    Tytuł oryginału: Pseudoductules in the rat liver in experimental adriamycin-induced nephrotic syndrome.
    Tytuł polski: Kanaliki rzekome w wątrobie szczura w doświadczalnym zespole nerczycowym wywołanym adriamycyną.
    Autorzy: Pedrycz Agnieszka, Wieczorski Marcin, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.154-160, il., tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • nefrologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Rozplem kanalików rzekomych w wątrobie jest stanem obserwowanym w niektórych chorobach wątroby u ludzi i u zwierząt doświadczalnych. Jest notowany w wirusowym lub alkoholowym zapaleniu wątroby, w marskości wątroby i w toksycznym uszkodzeniu wątroby. W przedstawionej pracy rozplem ten występował po jednorazowej dootrzewnowej dawce adriamycyny (5 mg/kg wagi ciała) podanej szczurom. Adramycyna podana w ten sposób jest używana do wywołania doświadczalnego zespołu nerczycowego.

    Streszczenie angielskie: Pseudodouctules proliferation in the liver is the condition observed in some liver diseases in human and experimental animals. It is observed in viral and alcoholic hepatitis, in hepatic cirrhosis and toxical liver damage. In that study pseudoductules were observed after i. p. single dose of adriamycin (5 mg/gk of body weight) adminsitered to rats. Adriamycin given in this way is used to induce experimental nephrotic syndrome.


    2384/2523

    Tytuł oryginału: Efficacy of the triple therapy: proton pomp inhibitors, amoxicillin and tynidazole in Helicobacter pylori infection treatment.
    Tytuł polski: Skuteczność eradykacji trójlekowej z zastosowaniem inhibitorów pompy protonowej z amoksycyliną i tynidazolem w leczeniu zakażeń spowodowanych przez Helicobacter pylori.
    Autorzy: Kos Marek, Zinkiewicz Krzysztof, Stefanek Janusz, Dąbrowksi Andrzej
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.161-166, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy jest przedstawienie wyników eradykacji trójlekowej z zastosowaniem inhibitora pompy protonowej z amoksycyliną i tynidazolem w leczeniu zakażenia spowodowanego przez Helicobacter pylori. Terapię przeprowadzono wśród 108 osób po wykonaniu endoskopii z biopsją i szybkim testem urazowym. W badaniu endoskopowym stwierdzano owrzodzenie dwunastnicy (72 osoby) lub zapalenie błony śluzowej dwunastnicy (36 osób). Wśród badanych 108 osób 51,85 proc. stanowili mężczyźni, a 48,15 proc. było kobietami. Były to osoby w wieku 15-81 lat (średnia wieku 44 lata). Po zastosowaniu eradykacji stwierdzono wyleczenie u 99 osób na 108, czyli w 91,66 proc. Brak porawy stwierdzono u 9 osób (8,34 proc.) - były to osoby w wieku 18-75 lat, co daje średnia 54,5 roku życia (wiek o 10,5 roku wyższy w stosunku do średniego w badanej grupie). Niepożądane objawy uboczne obserwowano u 14 osób, co stanowi 12,96 proc. badanej grupy. Uzyskane wyniki dowodzą dużej skuteczności tego schematu leczenia przy stosunkowo niskich kosztach oraz większej skutecznosci leczenia zakażeń spowodowanych przez Helicobacter pylori u osób w młodszym wieku.

    Streszczenie angielskie: The aim of the paper is to present the triple therapy results combined with the application of proton pump inhibitors with amoxicillin and tynidazole in treatment of the contagion caused by Helicobacter pylori. The therapy was carried out among 108 people after realization of endoscopic biopsy and with quick urease test. In the endoscopic investigation 72 people were found to have duodenum ulceration. Inflammation of mucous duodenum was found in 36 patients. Among 108 people under investigation 51.85 p.c. were men and 48.15 p.c. women .These people were aged between 15-81 (the average age was 44). After the use of eradication 99 out of 108 patients (91.66 p.c.) were cured. The alck of improvement was found in 9 people (8.34 p.c.). The age of these people varied from 18 to 75, which gives the aerage age 54.5 (this age is about 10 years and a half higher in relation to the average age of the examined group of patients). The results prove high efficiency of this schema of treatment in relation to comparatively low costs. they also indicate greater efficiency of the treatment of contagions caused by Helicobacter pylroi in younger people.


    2385/2523

    Tytuł oryginału: Histological changes in the pancreas of white rats after administering cephalexin and ethanol.
    Tytuł polski: Histologiczne zmiany trzustki szczurów białych po doświadczalnym podawaniu cefaleksyny i etanolu.
    Autorzy: Zarębska Alicja, Bakiera Katarzyna, Visconti Józef, Kwietniewska Małgorzata, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.167-173, il., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie polskie: Badania wykonano na szczurach - samcach rasy Wistar o masie ciałą około 200 g. Zwierzęta I grupy doświadczalnej otrzymywały 20 proc. alkohol etylowy do picia ad libitum, zwierzęta II grupy doświadczalnej - cefaleksynę w dawce 42 mg dziennie, zwierzęta II grupy doświadczalnej - cefaleksynę w dawce 42 mg dziennie, zwierzęta III grupy doświadczalnej - alkohol i cefaloskynę łącznie w wymienionych dawkach. Po 10 dniach zwierzęta usypiano eterem i pobierano trzustkę do badań. Na skrawkach o brubości 7 ć wykonano barwienie H + E i reakcję PAS na obecność mukopolisacharydów obojętnych. Po podawaniu alkoholu stwierdzono zmniejszenie aktywności wydzielniczej komórek egzokrynowych, a po podawaniu cefaleksyny - zwiększenie tej aktywności. Natomiast łączne podawanie alkoholu i antybiotyku powodowało zmiany troficzne, które można uważać za wstępne, ale jeszcze na tym etapie odwracalne, zmiany degeneracyjne.

    Streszczenie angielskie: The reserach was conducted on male Wistar rats weighing approximately 200 g. Animals of experimetnal group I were adminsitered 20 p.c. ethyl alcohol for drinking, animals of experimental group II - cephalexin in the dose of 42 mg daily, animals of experimental group III - simultaneously alcohol and cephalexin in the mentioned doses. After 10 days the animals were guillotined and pancreas was taken for research. On paraffin sections 7ć thick there were carried out H + E stain and PAS reaction aimed at discovering neutral mucopolysaccharides. After adminsitering alcohol there was stated a decrease in the activity. A simultaneous administration of ethyl alcohol and antibiotic casues trophic changes, which can be noticed as introductory, but at this stage - reversible, degenerative changes.


    2386/2523

    Tytuł oryginału: Histological examination of the submandibular gland following experimetnal administration of Metizol.
    Tytuł polski: Badania histologiczne ślinianki podżuchwowej po doświadczalnym podawaniu Metizolu.
    Autorzy: Lis-Sochocka Marta, Zarębska Alicja, Cichacz-Kwiatkowska Beata, Łańcut Mirosław, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.174-180, il., tab., bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Badano śliniankę podżuchwową szczurów rasy Wistar, którym podawano Metizol przez 21 dni i 42 dni w dawce 1 mg/kgm.c./24 godz. Stosowano barwienia H+E, met. PAS, met. Feulgena, met. Massona. Mierzono powierzchnię przekroju jąder komórkowych, powierzchnię przekroju cewek wydzielniczych i do uzyskanych danych stosowano obliczenia statystyczne. Zaobserwowano następujące zmiany. Po 21 dniach podawania Metizolu w śliniance podżuchwowej zwiększyła się liczba cewek i zwiększyła się powierzchnia ich przekroju. W komórkach budujących cewki zaobserwowano wiekszą ilość wydzieliny. Natomiast pęcherzyki uległy obkurczeniu. Po 42 dniach podawania Metizolu wygląd, liczba i barwliwość cewek i pęcherzyków upodobniły się do grupy kontrolnej.

    Streszczenie angielskie: The submandibular gland of the white Wistar rats was examined. The animals were given Metizol for 21 days and 42 days at the dose of 1 mg/kg b.m./24 h. The submandibular gland samples were taken for histological and histochemical examination. Then they were stained with hematoxylin and eosine as well as by masson's, PAS's and Feulgens method. The mean area of section of cell nuclei was measured. The resutls of examination were counted statistically. The following changes were noticed: After 21 days of administration of Metizol in the submandibular gland the mean area of the tubules cells some more secretion was noticed. The follicles shrank. After 42 days of adminsitration of Metizol the appearance, number and stainability of the tubules and follicles were similar to control group.


    2387/2523

    Tytuł oryginału: Histological examination of the Loeventhal gland after experimental administration of Metizol.
    Tytuł polski: Badania histologiczne gruczołu Loeventhala po doświadczalnym podawaniu Metizolu.
    Autorzy: Lis-Sochocka Marta, Zarębska Alicja, Cichacz-Kwiatkowska Beata, Łańcut Mirosław, Koziej Jacek, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.181-186, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Badano gruczoł Leoventhala szczurów rasy Wistar, którym podawano Metizol przez 21 dni i 42 dni w dawce 1 mg/kgm.c./24 godz. Stosowano barwienia H+E, met. PAS, met. Feulgena, met. Massona. Mierzono powierzchnię przekroju jąder komó kowych i do uzyskanych danych stosowano obliczenia statystyczne. Zaobserwowano następujące zmiany. Po 21 dniach podawania Metizolu w gruczole Loeventhala zmniejszyła sie powierzchnia przekroju jąder komórkowych. Po 42 dniach podawania Metizolu powierzchnia przekroju jąder komórkowych. Po 42 dniach podawania Metizolu powierzchnia przekroju jąder komó kowych również uległa zmniejszeniu, ale w mniejszym stopniu niż w grupie 1. Pojawiły się pęcherzyki proliferacyjne, któ e sa wyrazem aktywności mitotycznej.

    Streszczenie angielskie: The Loevenathal gland of the white Wistar rats examined. The animals were given Metizol for 21 days and 42 days at the dose of 1 mg/kg b.m./24 h. The Loeventhal gland's samples were taken for histological and histochemical examination. Then they there stained with hematoxylin and eosin, Masson's, PAS's, and Feulgen's method. The mean area of section of cell nuclei was measured. Results of examination were counted statistically. The following changes were noticed: after 21 days of administration of Metizol in the Loeventhal gland the mean area of the section ofcells nuclei was decreased; after 42 days of administration of Metizol the mean area of the section of cell nuclei was decreased as well, but to a lesser degree than in group 1. New follicles appeared which can be the expression of cell mitotic activity.


    2388/2523

    Tytuł oryginału: The influence of chronic obstructive pulmonary disease on the occurrence rate and intensification of osteoporosis.
    Tytuł polski: Wpływ przewlekłej obturacyjnej choroby płuc na częstość i nasilenie osteoporozy.
    Autorzy: Szymański Piotr, Mosiewicz Jerzy, Myśliński Wojciech, Dzida Grzegorz, Rymarz Ewa
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.187-195, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy była ocena związków osteopenii i osteoporozy z przewlekłą obturacyjną chorobą płuc, ocena częstości występowania i nasilenia zaburzeń masy i gęstości kości w tym schorzeniu oraz próba oceny relacji przyczynowo-sktukowych między obu chorobami. Badana grupa składała się z 77 osób chorych na POChP w różnych stadiach zaawansowania choroby i grupy kontrolnej. U wszystkich badanych wykonano badanie spirometryczne aparatem abcPneumoRS oraz badanie densytometryczne apratem Osteometr A/S, wykorzystujac metodę DEXA, a wyniki odniesiono do grup referencyjnych. Mierzono parametry spirometryczne statyczne i dynamiczne. Densytometrycznie oznaczano masę, gęstość mineralną kości, wskaźnik T, a badanym odcinkiem kości był dystalny odcinek kości promieniowej i łokciowej. W badaniach własnych potwierdzono zależność masy i gęstości kości od wieku, płci, masy i powierzchni ciała. Częstość ostoeporozy była większa w grupie pacjentów z POChP, szczególnie wśród kobiet. Stwierdzono zależność pomiędzy stopniem zaawansowania POChP a masą i gęstością mineralną kości. Im obturacja bardziej nasilona, tym niższe były wskaźniki masy kostnej. Na kształtowanie się wskaźników masy kostnej istotnie wpływała wielkość natężonej pojemności wydechowej pierwszosekundowej oraz stopień odwracalności obturacji, wykazany testem z beta-mimetykiem.

    Streszczenie angielskie: The aim of this study was the estimation of the relationship between ostoepenia and osteoporosis and chronic obstructive pulmonary disease (COPD). The group under investigation consisted of 77 people suffering from chronic obstructive pulmonary disease in different stages of its development and control group. All the patients underwent spirometry carried out by means of abcPneumoRS system and bone densitometry carried out by means of Osteometer A/S using the DEXA method; the results were compared with those of the reference groups. Static and dynamic lung volumnes were measured in all patients. By means of densitometry the mass, bone mineral density and T-score were determined in all patients' distal forearm. The research confirmed the relationship between the mass and density of bones and patietns' age, sex, weight and body surface. Osteoporosis frequency rate was much higher among patients with chronic obstructive pulmonary disease, particularly women. The following relationship between the degree of disease progression and the mass and mineral density of the bones was observed: the more advanced airflow obstruction was, the lower osseous mass coefficients were. Forced expiratory volume during the first second and airflow obstruction reversibility rate determined by means of bronchodilatator response also had a considerable influence on osseous mass coefficients.


    2389/2523

    Tytuł oryginału: The value of health in the opinion of patients after myocardial infarction.
    Tytuł polski: Wartość zdrowia w opinii osób po zawale mięśnia sercowego.
    Autorzy: Wrońska Irena, Mianowana Violetta, Kulik Teresa B.
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.196-203, il., tab., bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Zdrowie jako kontrwartość choroby jest jedną z wartości witalnych. Choroba zaś jako sytuacja stresowa dotyka dotychczasowych postaw człowieka oraz jego relacji z otoczeniem. Jest swego rodzaju okazją do zmiany hierarchii wartości i mobilizacji własnych możliwości twórczych. Celem badań było określenie postaw osób po zawale serca wobec wartości zdrowia. Badania przeprowadzono w roku 1999 w grupie osób, które w ostantich czterech latach przebyły zawał serca. Wyniki badań wskazują na to, iż zdrowie deklarowane jest jako wartość "najważniejsza z ważnych" i najbardziej pożądana w kategorii "celów i dążeń życiowych". W sytuacji przewlekłej choroby istnieje też większa niż wcześniej tendencja do podejmownaia wysiłków zdrowotnych. Generalnie jednak obserwuje się nadal zbyt małe zaangażowanie w kreowaniu zdrowego stylu życia zarówno na poziomie wiedzy i umiejętności, jak i niezbędnej do jego realizowania motywacji.

    Streszczenie angielskie: Health as the counter-value of disease is a vital value. The disease as a stressful situation affects the existing attitudes of man and his relations with the environment. This is as opportunity for changing the hierarchy of values and mobilising own creative potential. The study aimed at determining the attitudes of people after myocardial infarctions towards the value of health. Investigations were performed in 1999 in a group of 250 persons, who had had heart attack in the prevous 4 years' period. Study results indicate that health is declared as the value "most important of all most important ones" and the most desirable in the category of "life goals endeavours". A stronger than earlier tendency is also observed in the situation of chronic disease for undertaking wholesome efforts. Generally, however, there is still found too small dedication to create a healthy lifestyle, both on teh level of knowledge and skills and motivation necessary for carrying it out.


    2390/2523

    Tytuł oryginału: The level of alpha-antitrypsin and ceruloplasmin in the subretinal fluid of patients with rhegmatogenous retinal detachment.
    Tytuł polski: Poziom alfa-antytrypsyny i ceruloplazminy w płynie podsiatkówkowym pacjentów z otworopochodnym odwarstwieniem siatkówki.
    Autorzy: Matysik Anna, Toczołowski Jerzy, Jakubowska-Solarska Beata, Solski Janusz, Lewandowska-Furmanik Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.204-210, tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było oznaczenie poziomu AAT i CER w płynie podsiatkówkowym u chorych z otworopochodnym odwarstwieniem siatkówki (OOS). Badanie przeprowadzono u 41 chorych (22K, 19M), operowanych z powodu OOS w wieku od 24 do 81 lat. Grupa chorych została podzielona ze względu na rozległość i czas trwania OOS. U 24 chorych odwarstiwneie obejmowało 1 lub 2 kwadranty, a u 17 chorych dotyczyło 3 lub 4 kwadrantów. U 16 chorych OOS trwało krócej niż 2 tyg., u 6 chorych ok. 1 miesiąca, a u 19 chorych czas trwania OOS wynosiłod 1 do 3 miesięcy. Płyn podsiatkówkowy pobierano podczas zabiegu operacyjnego. Poziomy badanych substancji oznaczano metodą immunodyfuzji radialnej na płytkach NorPartigen firmy Behring. Średnie stężenie AAT w płynie podsitakówkoym u wszystkich chorych operowanych z powodu OOS wynosiło 0,739 ń 0.475 g/l, a CER = 0,186 ń 0,122 g/l. Średnie stężenia AAT nie różniły się w sposób istotny statycznie pomiędzy grupą z większymi i mniejszymi warstwieniami siatkówki, natomiast poziom CER był wyższy w grupie z większym OOS. Średnie stężenie AAT było w sposób istotny statystycznie wyższe w grupie z OOStrwającym od 1 do 3 miesięcy niż w grupie z OOS trwającym 2 tygodnie. Stężenie CER było w sposób istotny statystycznie wyższe u chorych z OOS trwającym od 1 do 3 miesięcy niż u chorych z OOS trwającym jeden miesiąc lub krócej. Stwierdzenie obecności białek ostrej fazy w płynie podsiatkówkowym sugeruje, że mogą one odgrywać pewną rolę w patogenezie OOS, wpływając na nasilene miejscowej reakcji zapalnej.

    Streszczenie angielskie: The aim of the study was to determine alpha-antitrypsin (AAT) and ceruloplasmin (CER) level in the subretinal fluid of paitents with rhegmatogenous retinal detachment (RRD). Investigation was performed in 41 patients (22 women, 19 men) operated on for RRD at the age from 24 to 81. The group of patietns was divided with regard to the extent and duration of RRD. In 24 patients detachment involved 1 or 2 quadrants and in 17 patients - 3 or 4 quadrants. In 16 subjects RRD lasted shorter than 2 weeks, in 6 patients - about one month and in 19 patients - from 1 to 3 months. The subretinal fluid was collected during operation. The levels of the examined substances were determined with the radial diffusin method on Nor-Partigen plates by Behring. The results were as follows: mean AAT concentration in the subretinal fluid of all the patients operated on for RRD was 0.739 ń 0.475 g/l and CER was 0.186 ń 0.122 g/l. Mean AAT concentrations did not differ statistically significantly between the group with bigger and smaller retinal detachments while CER level was higher in the group with a bigger RRD. Mean AAT and the CER concentration was statisically significantly higher in the group with RRD lasting from 1 to 3 months compared with the group with RRD lasting shorter than one month. Conclusions: the fact of finding actue phase proteins in subretinal fluid suggests that they may play a part in the pathogenesis of RRD by affecting the intensity of local inflammatory reaction.


    2391/2523

    Tytuł oryginału: Does a correlation between transaminase activity and the size of the liver in psoriatic children exist?
    Tytuł polski: Czy istnieje zależność pomiędzy aktywnością transaminaz a wielkością wątroby u dzieci chorych na łuszczycę?
    Autorzy: Lechowska-Mazur Irena, Pietrzak Aldona, Urban Janusz, Lecewicz-Toruń Barbara
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.211-218, tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Łuszczyca jest chorobą, która dotyczy całego organizmu. Na podstawie piśmiennictwa stwierdzono, iż istnieje możliwość, że proces chorobowy dotyczący skóry może być odzwierciedlony poprzez wzmożoną aktywnosć komórki wątroby. Aktywność tę oceniano za pomocą stężenia tymolu, ALAT, ASPAT oraz pomiarów morfometrycznych wątroby w 3 płaszczyznach przekroju. Badania wykonano u 56 dzieci chorych na łuszczycę i 32 zdrowych dzieci dobranych wiekiem i płcią. W żadnym badanym parametrze nie stwierdzono różnic pomiędzy dziećmi chorymi a zdrowymi. Nie stwierdzono istnienia zależności pomiędzy łuszczycą a powiększeniem wymiarów wątroby ocenianej za pomocą usg jak również pomiędzy łuszczycą a próbą tymolową i transaminazami ALAT i ASPAT.

    Streszczenie angielskie: Psoriasis is a systemic disease. On the basis of the lierature it has been stated that there is a possibility that a disease which is going on in the skin may be reflected by the increase in the activity of the hepatic cell. This activity was estimated by the McLaghan units, concentration of aspartate and alanine aminotransferases and morphometric measurements of the liver in 3 oblong dimensions. The study was conducted on 56 children suffering from psoriasis and 32 healthy ones matched with sex and age. None of the investigated parameters differs statistically between ill and healthy children. No association was stated between psoriasis and the enlargement of the liver dimensions by means of ultrasonography or the McLaghan units, ALAT and ASPAT.


    2392/2523

    Tytuł oryginału: The effect of epilepsy on emotional state in Hamilton and Beck questionnaire studies.
    Tytuł polski: Ocena stanu emocjonalnego pacjentów z padaczką w badaniach z zastosowaniem kwestionariuszy Hamiltona i Becka.
    Autorzy: Chmielewska Barbara, Stelmasiak Zbigniew
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.219-225, il., tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Zaburzenia depresyjne często współwystępują z organicznymi schorzeniami układowymi, również toczącymi się w układzie nerwowym. Spośród schorzeń neurologicznych szczególnie osoby chorujące na padaczkę doświadczają różnorodnych dysfunkcji w sferze funkcjonowania psychicznego. Zaburzenia lękowe i depresyjne są notowane dwu-trzykrotnie częściej w tej populacji w porównaniu z osobami zdrowymi. W prezentowanym badaniu porównano występownaie zaburzeń o charakterze derpesyjnym u dorosłych pacjentów z nowo zdiagnozowaną padaczką oraz u chorujących przewlekle, u których uzyskano remisję choroby, jak i u osób z padaczką lekooporną. Oceny zaburzeń dokonano przy wykorzystaniu kwestionariuszy depresji Hamiltona oraz Becka, przeprowadzając badanie u każdego chorego jednorazowo odpoweidnio przez lekarza oraz samego pacjenta w okresie pomiędzy napadami padaczkowymi. W badaniach obydwoma kwestionariuszami wykazano zgodnie wyższe wartości w skali zaburzeń depresyjnych u chorych nowo zdiagnozowanych w porównaniu z chorującymi od wielu lat, zarówno tych, u których w wyniku farmaktoerapii uzyskano remisję objawów, jak i u pacjentów z lekoopornością. Uzyskane różnice odpowiadały wartościom typowym dla odpowiednio umiarkowanego i łagodnego poziomu zaburzeń depresyjnych. Można przypuszczać, że ustlaenie diagnozy padaczki, w związku ze stygmatyzacją, jaką sprowadza to schorzenie, oraz licznymi ograniczeniami życiowych aktywności, może być znaczącym czynnikiem stresującym, warunkujacym występowanie zaburzeń depresyjnych w początkowym okresie trwania choroby.

    Streszczenie angielskie: Patients with epilepsy present higher rate of psychological and psychaitric problems and emotional disturbances are estimated as the most frequent ones with prevalence of depression about tree times higher than it was observed in general population. In the presented study the occurrence of depressive symptoms was compared in a total of 60 adult patients with newly recognised and chronic epilepsy during remission of illness as well as pharmacoresistant. 21-items Hamilton Depressive Scale and Beck Depressive Inventory were applied once in each testified patient, consecutively by a phsyician or a patient himself during interictal period. Our study has found a higher level of depressive signs in newly diagnosed than in chronic patients during remission of illness but also in patients with an active process. The scoring rates both on HDRS and BDI were respectively characteristic of moderate or mild intensity of depressive distrubances. This comparison allows us to make a suggestion that diagnosis of epilepsy with its well-known stimgatison and limitations of different life activities may act as a stressing factor that enhances anxiety and depressive reactions in early phase of illness.


    2393/2523

    Tytuł oryginału: Effectiveness of adjunctive therapy with tiagabine in mentally disabled patients with epilepsy.
    Tytuł polski: Efektywność tiagabiny w politerapii w padaczce u pacjentów z dysfunkcją intelektualną.
    Autorzy: Chmielewska Barbara, Stelmasiak Zbigniew
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.226-236, il., tab., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: W licznych badaniach, poza skutecznością, pokreślano korzystny wpływ tiagabiny, leku przeciwpadaczkowego nowej generacji, na funkcjonowanie neuropsychiczne pacjentów z padaczką jak również minimalne ryzyko wystąpienia niepożądanych zaburzeń psychicznych. W obecnym prospektywnym, niekontrolwoanym placebo, krótkoterminowym 6-miesięcznym badaniu oceniono skuteczność i tolerancję stosowania tiagabiny jako leku dodanego w grupie 30 młodych dorosłych pacjentów z padaczką lekooporną oraz współistniejacym upośledzeniem umysłowym w stopniu lekkim lub umiarkowanym. U 40 proc. leczoncyh stwierdzono przynajmniej 50 proc. redukcję częstości napadów (responderzy), liczba dni z napadami zmniejszyła się z 9,9 do 6,3 na miesiac, a średnia częstość napadów uległa zmniejszeniu z 14,9 do 9,2 na miesiąc. Odnotowano także złagodzenie ciężkości napadów: odsetek pacjentów z napadami umiarkowanymi zwiększył się z 30 proc. przed stosowaniem tiagabiny do 50 proc. po 24 tygodniach terapii, a odsetek chorych z napadami ciężkimi zmniejszył się odpowiednio z 30 do 16 proc. U pacjentów-responderów w badaniu kwestionariuszem jakości życia stwierdzano poprawę wszystkich ocenianych funkcji, ale najwyraźniej funkcji poznawczych, korzystną ocenę wpływu leczenia na ogólne samopoczucie oraz poprawę w funkcjonowaniu społecznym. Większość pacjentów (90 proc.) nie doświadczyła istotnych objawów niepożądanych leczenia; najczęstsze skargi wiązały się z łagodnymi, przemijającymi efektami neurotoksycznymi ...

    Streszczenie angielskie: Previous reports justified positive impact of tiagabine, a new-generation antiepileptic drug on neuropsychological functioning as well as minimal risk of psychiatric exacerbations. In this prospective, open, observational, non-comparative, short-term - 6 months' study we evaluated efficacy and tolerability of tiagabine as add-on in polytherapy in 30 young adults with both refractory epilepsy and mild or moderate mental retardation. About 40 p.c. of patients experienced improvement in seizure frequency of 50 p.c. or more and none complained of seizure deterioration. Overall seizure frequency fell down from a mean 9.9 at the baseline to 6.3 seizure days per month. The seizure rate was reduced from 14.9 to 9.2 per month after 24 weeks of add-on phase. Adjunctive tiagabine therapy appeared to be associated with reduciton in overall seizure severity characteristics expressed as enhancement of mild of mild seizures from 30 to 50 p.c. of patients and reduction in severe seizures from 30 to 16 p.c. Responders reported an improvement in most health related quality of life domains but mostly cognition, medication effects and social functioning. The majority (90 p.c.) of patients did not report additional adverse effects with tiagabine; the most common complains associated with central nervous system (vertigo, weakness, nervousness) were transient and did not cause discontinuation. Blood counts and liver funcitonal tests did not show any clinically relevant changes. In this ...


    2394/2523

    Tytuł oryginału: The level of total sialic acid, alfa-antitrypsin, ceruloplasmin in the serum of patients with choroidal melanoma.
    Tytuł polski: Poziom całkowitego kwasu sialowego, alfa-antytrypsyny i ceruloplazminy w surowicy krwi chorych na czerniaka błony naczyniowej gałki ocznej.
    Autorzy: Matysik Anna, Toczołowski Jerzy, Starzycka Maria, Jakubowska-Solarska Beata, Solski Janusz, Romanowska-Dixon Bożena, Lewandowska-Furmanik Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.237-244, tab., bibliogr. 17 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Czerniak błony naczyniowej oka jest chorobą o złym rokowaniu z powodu występowania przerzutów. Trwają poszukiwania odpowiednich markerów nowotworowych surowicy krwi, które mogłyby być pomocne w ocenie klinicznej choroby z czerniakiem błony naczyniowej. Celem pracy było zbadanie poziomu całkowitego kwasu sialowego (TSA), stosunku całkowitego kwasu sialowego do białka całkowitego (TSA/TP) oraz poziomu alfa-antytrypsyny (AAT) i ceruloplazminy (CER) u chorych na czerniaka błony naczyniowej gałki ocznej. Metoda: stężenia TSA, TP, AAT i CER były badane u 61 chorych na czerniaka bony naczyniowej. Grupę kontrolną stanowiły 84 zdrowe osoby. U 36 chorych stweirdzano obecność dużych guzów wewnątrzgałkowych, a u 25 mniejszych guzów. 36 chorych było leczonych brachyterapią. Wyniki: Średnie stężenie TSA u wszystkich chorych wynosiło 84,86 ń 19,37 mg/dl i było wyższe w sposób istotny statystycznie niż w grupie kontrolnej grup 53,63 ń 8,47 mg/dl (p 0,001). Poziom TSA był wyższy u chorych z większymi czerniakami wewnątrzgałkowymi niż u chorych z mniejszymi guzami. Nie wykazano różnicy poziomów badanej substancji między grupą leczonych brachyterapią oraz nieleczonych w ten sposób. Średnie stężenie AAT wynosiło w grupie chorych 236,56 ń 141,53 mg/dl, a w grupie kontrolnej 226,42 ń 46,74 mg/dl, ale róznice nie były istotne statystycznie. Poziom CER w grupie chorych wynosił 28,25 ń 11,01 mg/dl, a w grupie kontrolnej 29,56 ń 6,33 mg/dl, ale róznice nie były istotne statystycznie. ...

    Streszczenie angielskie: Malenoma of the choroid is a fatal disease because of its metastases. The quest is ongoing for more reliable serum markers for detecting and staging ocular melanoma. Total serum sialic acid and acute phase proteins are valuable adjuncts in the management of malignancies, including melanoma. The aim of the paper was to assess the level of total sialic acid (TSA), total sialic acid to total protein (TP) ratio (TSA/TP) and the level of alfa-antitrypsin (AAT) and ceruloplasmin (CER) in patients with choroidal melanoma. The concentrations of TSA, TP, AAT and CER were evaluated in 61 patients with choroidal melanoma and 84 healthy controls. 36 patients had larger tumors and 2 patients had smaller melanomas. 36 patients were treated with brachytherapy. The mean concentration of TSA in all intraocular melanoma patients was 84.86 ń 19.37 mg/dl and was significantly higher than in control group 53.63 ń 8.47 mg/dl (p 0,001). TSA level was signficantly higher in patients with large tumors than in those with smaller choroidal melanomas. There were not differences between group sof patients treated with brachytherapy and those not treated. TSA/TP in melanoma patients was 11.88 ń 2.97 and it was higher than in control group 7.32 ń 1.21 (p 0.001). AAT level was 236.56 ń 141.53 mg/dl in the group of melanoma patients and in the contorl group was 226.42 ń 46.74 mg/dl but the differences were not statistically significant. The concentration of CER in the study group was 28.25 ń ...


    2395/2523

    Tytuł oryginału: Influence of adenosine receptors on the development of caerulein-induced acute pancreatitis.
    Tytuł polski: Wpływ receptorów adenozynowych na rozwój eksperymentalnego ostrego zapalenia trzustki wywołanego ceruleiną.
    Autorzy: Szczerbiński Mariusz, Celiński Krzysztof, Słomka Maria, Kasztelan-Szczerbińska Beata, Cichoż-Lach Halina
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.245-256, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: W przebiegu OZT (ostrego zapalenia trzustki) dochodzi do hipoksji w wyniku wazokonstrukcji oraz do aktywacji enzymów lizosomalnych i trawiennych powodujących samotrawienie i uszkodzenie trzustki. W konsekwencji dochodzi do pobudzenia leukocytów oraz zwiększenia ekspresji cząstek adhezyjnych, umożliwiających marginację i adhezję pobudzonych leukocytów do śródbłonka naczyń. Pobudzone leukocyty są źródłem prozapalnych cytokin i wolnych rodników tlenowych, które nasilają odczyn zapalny. Doniesienia o tym, że adenozyna może zapobiegać aktywacji wymienionych procesów w przebiegu niedokrwienia, skłoniły nas do przeprowadzenia badania. Doświadczenie wykonano w dwóch etapach. Pierwszy mmiał na celu ocenę wpływu agonistów i antagonistów receptorów adenozynowych na nieuszkodzoną, prawidłową trzustkę, a drugi miał określić wpływ tych substancji na rozwój OZT indukowanego ceruleiną. Podczas pierwszego etapu doświadczenia, po dootrzewnowych iniekcjach badanych substancji, odpowiednio: DPCPX - antagonisty receptora A1, CGS 21680 - agonisty receptora A2, ZM241385 - antagonisty receptora A2, IB-MECA - agonisty receptora A3, zwierzęta otrzymywały dożylną infuzję soli fizjologicznej. Zwierzętom z grupy kontrolnej podawano wyłącznie dwunastogodzinną dożylną infuzję 0,15 M NaCl. W drugim etapie doświadczenia, po dootrzewnowym podaniu, podobnie jak w pierwszym etapie, agonisty lub antagonisty receptorów adenozynowych, u badanych zwierząt wywoływano OZT, podając dwunastogodzinną dożylną ...

    Streszczenie angielskie: Acute pancreatitis leads to hypoxia caused by vasoconstriction and to activation of lysosomal and digestive enzymes resulting in pancreas autodigestion and damage. This causes activation of leucocytes and increased expression of adhesive molecules enabling margination and adhesion of activated leucocytes to the endothelium. Activated leucocytes are the source of proinflammatory cytokins an oxygen-free radicals which intensify the inflammatory response. The reports indicating that adenosine may prevent activation of the above-mentioned processes in ischaemia prompted us to undertake this study. The study was performed in two stages. The first stage was to evaluat the effects of agonists and antagonists of adenosine receptors on normal pancreas while the second one was to determine the influene of these substances on the development of caeruleininduced acute pancreatitis. During the first stage, the animals were injected intraperitoneally with the substances examined: the A1 receptor antagonist - DPCPX, the A2 receptor agonist - CGS 21680, the A2 receptor antagonist - ZM 241385 and the A3 receptor agonist - IB-MECA and then received intravenous saline. The control animals were subjected only to the 12 h intravenous infusion of 0.15 M NaCl. During the second stage, after the intraperitoneal administration of adenosine receptor agonists and antagonists (as in the first stage), acute pacnreatitis was induced with the 12h intravenous infusion of 5ćg/kg/h caerulein. ...


    2396/2523

    Tytuł oryginału: Ways of spending leisure time by the third year-students of the Faculty of Pharmacy, Medical University of Lublin.
    Tytuł polski: Sposoby spędzania czasu wolnego przez studentów III roku Wydziału Farmacji Akademii Medycznej w Lublinie.
    Autorzy: Czabak-Garbacz Róża, Skibiniewska Agnieszka, Mazurkiewicz Piotr, Gdula Agnieszka
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.257-263, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy była ocena wypoczynku studentów III roku Wydziału Farmacji Akademii Medycznej w Lublinie. Przeanalizowano m.in. ilość czasu przeznaczanaego na zajęcia na uczelni oraz najczęstsze formy spędzania czasu wolnego w zależności od płci. Badaniami przeprowadzonymi za pomocą ankiety objęto 114 studentów (82 kobiety i 32 mężczyzn). W pracy wykazano, że kobiety okazały się bardziej pracowite i obowiązkowe niż mężczyźni, ponieważ więcej czasu poświęcały na zajęcia na uczelni, stąd dysponowały mniejszą ilością czasu wolnego. Stwierdzono, że najbardziej popularnymi czynnościami wykonywanymi w czasie wolnym były: sen, na który ankietowani poświęcali średnio 6,8 godz. dziennie, nauka (średnio 3,6 godz.), słuchanie radia (2,9 godz.), rozmowy z koleżankami, kolegami (1,9 godz.), czynności higieniczne (1,1 godz.), na którą to czynność kobiety poświęcały więcej czasu niż mężczyźni; oglądanie telewizji (1,1 godz.) oraz obowiązki domowe (1,1 godz.). Najmniej czasu wolnego studenci poświęcali na spacer (kobiety nieco więcej niż mężczyźni) oraz na sport, który był bardziej popularny wśród mężczyzn. Udział studentów w życiu kulturalnym ograniczał się jedynie do spotkań towarzyskich oraz wyjść do kin, natomiast niezbyt popularną formą spędzania czasu wolnego było uczestnictwo w przedstawieniach teatralnych, widowiskach operowaych, koncertach i wystawach. W czasie wakacji, które powinny być przeznaczone na wypoczynek, istotnie wzrastała liczba studentów podejmujących pracę zarobkową. Zauważono, że sposób spędzania czasu wolnego przez studentów III roku Wydziału Farmacji Akademii Medycznej w Lublinie, zarówno kobiet, jak i mężczyzn, w ciągu dnia był bardzo podobny, różnice dotyczyły tlko wymiaru czasu poświęcanego na poszczególne czynności.

    Streszczenie angielskie: The aim of the study was the assessment of leisure time among third-year students from the Faculty of Pharmacy of the Medical University of Lubin. It analysed quantity of time devoted to schoold activity and ways of spending free time. The study involved 114 students (82 women and 32 men). The study revealed that women had less free time than men, who, most probably did not attend some lectures. The most popular activities among the questioned students were: sleeping (average 6.8 hours a day), studying (average 3.6 hours a day), listening to the radio (average 2.9 hours a day), talking with triends (average 1.9 hours a day), personal hygiene (average 1.1 hours a day), watching TV (average 1.1 hours a day), personal hygiene (average 1.1 hours a day), watching TV (average 1.1. hours a day), housework. Students devoted the least of their free time on active rest, for example walking (women did it more often than men) or practising sport (more popular among men). Cultural life of the students consisted only of meetings with friends and going to the cinema (women did it more often). The least popular way of spending free time was going to the theatre, opera, concerts and exhibitions. Few students spent their time working. Their number increased significantly during holidays. The way of spending free time by third-year students from the Faculty of Pharmacy (both men and women) during the day was similar, differences related only to the amount of time devoted to each activity.


    2397/2523

    Tytuł oryginału: The influence of diazepam on the behaviour of rabbits in spontaneous conditions.
    Tytuł polski: Wpływ diazepamu na zachowanie królików w warunkach spontanicznych.
    Autorzy: Czabak-Garbacz Roża, Cygan Beata, Chomicki Mariusz, Khonicheva Natalia M.
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.264-270, il., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie polskie: Praca dotyczyła popularnie używanego leku - diazepamu, znanego także pod nazwą handlową Relanium. Testowano dwie dawki leku: 0.2 mg/kg oraz 1 mg/kg przez okres dwóch godzin na grupach królikoów liczących po dziesięć zwierząt. Obserwacja prowadzona była w spokojnym środowisku laboratorium po uprzednim jednogodzinnym okresie adaptacji. W strukturze zachowania wyróżniono szereg faz: obserwację czynną, obserwację bierną, komfort, naprężenie, gruming, jedzenie i picie. Obie dawki diazepamu wyeliminowały całkowicie fazę naprężenia oraz wywołały podobne zmiany w innych fazach zachowania, jednak ich czas i siła działania były różne. Dawka mniejsza w pierwszej godzinie w statystycznie istotny sposób wydłużyła fazę komfortu kosztem skrócenia czasu obserwacji czynnej i biernej. W drugiej godzinie zachowała te same tendencje, chociaż bez statystycznej istotności. Dawka większa spowodowała podobne zmiany zachowania, istotne statystycznie zarówno w pierwszej, jak i drugiej godzinie, ale ich natężenie było silniejsze niż po mniejszej dawce. Zaobserwowane zmiany zachowania królików w warunkach spontanicznych potwierdzają przeciwlękowe, uspokajające oraz zwiotczające właściwości diazepamu.

    Streszczenie angielskie: The study dealed with a popular drug diazepam also known as Relanium. Two doses of the substance were tested: 0.2 mg/kg and 1 mg/kg. The experiment was carried out on 10-rabbit groups for two hours. The animals were observed in peaceful environment of the laboratory after one hour of adaptation. There were distinguished a few phases of behaviour: active and passive observation, comfort, tension, grooming, food and water intake. Both doses eliminated completely the tension phase. Changes in other phases were similar to each other but depending on the dose there were differences in strength and duration. The smaller dose caused significant prolongation of the comfort phase at the expense of active and passive observation time decrease during the first hour of observation. The second hour trends were not changed but lost their statistical relevance. The changes caused by the bigger dose were almost identical and they were statistically significant during both hours of the experiment, but their amplitude was stronger than that caused by the lower dose. The outcome of the experiment confirms anxiolytic, sedative and miorelaxant properties of diazepam.


    2398/2523

    Tytuł oryginału: The influence of Atorvastatin on ultrastructure of rat pancreatic exocrine cells in the course of experimental intoxication with ethanol.
    Tytuł polski: Wpływ Atorvastatyny na ultrastrukturę komórek zewnątrzwydzielniczych trzustki szczura w przebiegu doświadczalengo zatrucia etanolem.
    Autorzy: Visconti Józef, Celiński Krzysztof, Stępniewska Maria, Sekita-Krzak Joanna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.271-275, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Badania wykonano na szczurach samcach rasy Wistar, dojrzałych płciowo. Zwierzęta z grupy doświadczalnej i otrzymywały Atorvastatynę wa dawce 0,28 mg na dobę codziennie przez 3 tygodnie, grupa doświadczalna II oprócz Atorvastatyny była pojona 20 p.c. etanolem ad libitum. Badania ultrastruktury komórek zewnątrzwydzielniczych trzustki wykazały pobudzenie procesów wydzielniczych w komórkach zwierząt otrzymujących Atorvastatynę i znaczne uszkodzenie strutkur komórkowych w drugiej grupie doświadczalnej, większe aniżeli w trzustce zwierząt kontrolnych, które piły etanol.

    Streszczenie angielskie: The experimet was carried out on mature Wistar male rats. The animals from experimental group I received Atorvastatin in the dose 0.28 mg/24h for 3 weeks. Experimental group II received 20 p.c. ethanol ad libitum apart from Atorvastatin. Ultrastructural examinations of pancreatic exocrine cells showed the stimulation of secretory processes in cells of animals receiving Atorvastatin and considerable damage of cell organelles in experimental group II, more intense than in the pancreas of control animals which drank ethanol.


    2399/2523

    Tytuł oryginału: Intravascular thrombosis as a result of central venous access.
    Tytuł polski: Zakrzepica wewnątrznaczyniowa jako następstwo centralnego dostępu naczyniowego.
    Autorzy: Biernacka Jadwiga, Nestorowicz Andrzej, Wach Małgorzata
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.276-284, il., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • hematologia
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie polskie: Centralny dostęp naczyniowy stanowi obecniw w wielu dziedzinach medycyny jeden z podstawowych elementów postępowania leczniczego. Liczne korzyści wynikające z obecności cewnika w żyle głównej górnej wiążą się niestety z możliwością wystąpienia powikłań, z których zakrzepica żylna jest najbardziej istotna klinicznie. Celem pracy było ustalenie rocznej liczby i naturalnego przebiegu tego powikłania u chorych wieloprofilowego szpitala klinicznego. Kaniulacji naczyń centralnych dokonywali lekarze anestezjolodzy. Przeprowadzono 887 kaniulacji, jawną klnicznie zakrzepicę żył centralnych stwierdzono u 5 chorych. Analiza zebranego materiału pozwoliła na stwierdzenie, że zakrzepica wewnątrznaczyniowa jest powikłaniem rzadkim, najczęściej związanym z rozległym upośledzeniem drożności centralnego układu żylnego. Mimo zastosowanej terapii nie zawsze dochodzi do pełnej rekanalizacji naczyń. Zatorowość płucna w przebiegu zakrzepicy naczyń centralnych wystąpiła tylko u jednego pacjenta i miała charakter mnogich drobnych zmian. Wydaje się, że wobec groźby trwałych iniebezpiecznych dla życia powikłań zakrzepicy należy dążyć do zminimalizowania ryzyka przez dokładną obserwację miejsca wprowadzenia kaniuli i wczesne wdrożenie leczenia przeciwzakrzepowego.

    Streszczenie angielskie: Central venous access represents one of the most basic therapeutic procedures in modern medicine. Unfortunately, numerous advantages that result from maintaining a central venous line are accompanied by some complications among which the venous thrombosis is the most significant clinically. The study was designed to assess frequency and natural history of this complication in the setting at a multi profile clinical hospital. Central venous cannulation was performed by a fully qualified anaesthesiologist in every case. There were 887 cannulations and only 5 patients with clinically significant venous thrombosis. The analysis of the collected data allowed us to state that the frequency of itnravascular thrombosis is low, but this complication is often associated with extensive impairment of patency of the central veins. Full recanalization is not always achieved regardless of the treatment applied. Pulmonary embolism in the course of central venous thrombosis was diagnosed in one patient only and appeared as a multiple and fine X-ray infiltrates. It seems that in the presence of permanent or even life threatening complications of central venous thrombosis their risk should be minimized by frequent examination of the cannulation site and early of antithrombotic treatment.


    2400/2523

    Tytuł oryginału: Changes in health status of the Polish population after 1990.
    Tytuł polski: Zmiany w stanie zdrowia populacji Polski po roku 1990.
    Autorzy: Kalinowski Paweł
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.285-291, il., tab., bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Na stan zdrowia społeczeństwa polskiego w minionej dekadzie duży wpływ wywarły przemiany ekonomiczne i polityczne. Jednym ze sposobów oceny takiej transformacji jest analiza zmian w strukturze przyczyn zgonów i umieralności. W celu przedstawienia zmian w stanie zdrowia populacji Polski, które dokonały się po roku 1990, w pracy przeanalizowano dane epidemiologiczne dotyczące umieralności i przyczyn zgonów w spoełczeństwie polskim w latach 1990-2000.

    Streszczenie angielskie: The health status of the Polish population in the past decade has been strongly influenced by economic and political transformations. One of the measures of such transformations is the analysis of alteration in the structure of causes of deaths and mortality rates. In order to present the changes in health status of Polish population that occurred after the year 1990, in the paper there have been analsyed epidemiological data in the form of mortality rates and the causes of deaths in the Polish population in the years 1990-2000.


    2401/2523

    Tytuł oryginału: Evaluation of state of deciduous dentition in children in Lublin day nurseries.
    Tytuł polski: Ocena stanu uzębienia mlecznego u dzieci ze żłobków lubelskich.
    Autorzy: Mielnik-Błaszczak Maria, Struska Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.292-298, bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Zbadano 408 dzieci w wieku od 1 do 4 lat z lubelskich złobków. Celem pracy była ocena średniej liczby puw i poziomu higieny jamy ustnej u tych dzieci. Badania stwierdziły, że frekwencja próchnicy i wskaźnik OHI były wysokie.

    Streszczenie angielskie: 408 children aged 1-4 years from Lublin nurseries were examined. The paper aimed at evaluation of the mean number of dmf and the level of oral hygiene in these children. The studies confirmed high caries frequency as well as high OHI index.


    2402/2523

    Tytuł oryginału: The role of oral hygiene in dental caries prevention in children and adolescents.
    Tytuł polski: Rola higieny jamy ustnej w profilaktyce próchnicy zębów u dzieci i młodzieży.
    Autorzy: Krawczyk Dorota, Mielnik-Błaszczak Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.299-302, bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Na podstawie piśmiennictwa i własnych doświadczeń klinicznych przedstawiono rolę higieny jamy ustnej w profilaktyce próchnicy zębów.

    Streszczenie angielskie: The role of oral hygiene in prevention of caries and periodontal diseases has been presented based on the literature and own clinical experience.


    2403/2523

    Tytuł oryginału: High resolution computed tomography (HRCT) in diffuse pulmonary intraparenchymatous disorders.
    Tytuł polski: Tomografia komputerowa wysokiej rozdzielczości (TKWR) w rozlanych schorzeniach śródmiąższowych płuc.
    Autorzy: Złomaniec Janusz, Guz Wiesław, Matysiak Magłorzata, Krupski Witold
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.303-313, il., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wartość tomografii komputerowej wysokiej rozdzielczości (TKWR)przedstawiono w materiale 62 rozlanych schorzeń śródmiąższowych płuc. Analizowano uwidocznienie zacienień typu szkła mlecznego, plastra miodu, zmian guzkowych, rozedmy pęcherzykowej zwykle skojarzonej ze śródpłacikową lub przyprzegrodową. Wydechowe przekroje TKWR ułatwiały odkrycie pułapek powietrznych. W TKWR było możliwe zróżnicowanie zmian aktywnych i nieodrwacalnych (zwłóknień).

    Streszczenie angielskie: The value of high resolution computed tomography (HRCT) was presented in the material of 62 diffuse pulmonary intraparenchymatous disorders. Visualisation of milk-glass type opacities, honeycomb picture, nodular changes, alveolar emphysema, usually associated with intralobular or periseptal, was analyzed. Expirational HRCT section facilitate the discovery of air traps. HRCT make possible differentiation of active changes from irreversibles (fibrous).


    2404/2523

    Tytuł oryginału: Insulin resistance, parameters of carbohydrate metabolism, anthropometric parameters, interactions in diabetic patients.
    Tytuł polski: Wzajemne zależności pomiędzy insulinoopornością, wskaźnikami gospodarki węglowodanowej i parametrami antropometrycznymi u chorych z cukrzycą typu 2.
    Autorzy: Szydłowski Wojciech, Łopatyński Jerzy
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.314-321, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie polskie: Celem pracy było zbadanie zależności pomiędzy insulinoopornością a podstawowymi wskaźnikami gospodarki węglowdanowej i parametrami antropometrycznymi. Badaniem objęto 36 osób z cukrzycą typu 2 leczoncyh doustnymi lekami hipoglikemizującymi. Grupę kontrolną stanowiło 37 osób bez cukrzycy. Porównywane grupy nie różniły się w sposób istotny parametrami antropometrycznymi. Wykazano istotne zależności pomiędzy insulinooprnością a stężeniem insuliny i glukozy oznaczanym w surowicy krwi żylnej na czczo oraz pomiędzy insulinoopornością a poziomem HbA1c w obydwu badanych grupach. W grupie osób bez cukrzycy stwierdzono istotne zależności pomiędzy insulinopornością a parametrami antropometrycznymi (obwód brzucha, BMI, WHR). Jednocześnie nie stwierdzono takich zależności w grupie osób z cukrzycą typu 2.

    Streszczenie angielskie: The aim of the study was to investigate relationships between insulin resistance index and basic parameters of carbohydrate metabolism and anthropometric values. We investigated patients with diabetes mellitus t.2 (n = 36) treated with oral hypoglycemic agents. The control group represented patients with normal glucose tolerance (n = 37). Both, the group with diabetes and control had similar values of anthropometric parameters. The insulin resistance index showed significant correlation with fasting plasma insulin and glucose concentrations and HbA1C level in both groups. In the group with normal glucose tolerance we showed significant correlations between insulin resistance index and anthropometric parameters (waist circumference, BMI, body weight, WHR). We did not find any signfiicant relationships between insulin resistance and anthropometric parameters in the diabetic group.


    2405/2523

    Tytuł oryginału: The loss of alveolar processus, mandible density and bone tissue structure in reference to the computerized analysis of intraoral radiography.
    Tytuł polski: Zanik wyrostka zębodołowego oraz gęstość i struktura tkanki kostnej żuchwy na podstawie komputerowej analizy obrazu radiowizjograficznego.
    Autorzy: Tomaszewski Tomasz, Czerwiński Edward
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.322-328, il., tab., bibliogr. 21 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • stomatologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: U 98 pacjentów leczonych w Klinice Chirrugii Stomatologicznej i Szczękowo-Twarzowej AM oraz w Poradni Osteoporozy Instytu Medycyny Wsi w Lublinie przeprowadzono badania radiowizjograficzne okolicy zębów przedtrzonowych po stronie lewej. Na podstawie analizy obrazu wg określono wybrane wskaźniki gęstości i struktury kości żuchwy oraz stopień zaniku wyrostka zębodołowego. Stwierdzono, iż stopień zaniku wyrostka zębodołowego istotnie koreluje z wiekiem badanych, a także wykazuje ujemną korelację z gęstością mineralną i równoważnikiem zawartości minerałów w kości żuchwy. Uzyskane wyniki wskazują na to, że zmiany demineralizacyjne mogą w znaczący sposób uczestniczyć w utracie uzębienia.

    Streszczenie angielskie: 98 patients treated in the Department of Dental and Maxillofacial Surgery, Medical University and Institute of Rural Medicine in Lublin had radiovisiographically tested premolar teeth area on the left side. Reviewing radiovisiographical picture, there were defined bone mineral density and mandible bone structure and degree of loss of alveolar processus. It was concluded that the degree of loss of alveolar processus is significantly correlated with the researched patients' age, and is inversely correlated with mineral density and equivalent of mandible bone mineral contents. The achieved results prove that demineralisation changes can significantly influence teeth loss.


    2406/2523

    Tytuł oryginału: Assessment of density and mandible bone structure in patients with generic osteoporosis symptoms.
    Tytuł polski: Ocena gęstości i struktury kości żuchwy u pacjentów z ogólnoustrojowym procesem osteoporozy.
    Autorzy: Tomaszewski Tomasz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.329-341, il., tab., bibliogr. 18 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: U 130 chorych z rozpoznaną osteoporozą i 110 osób grupy kontrolnej wykonano badania radiowizjograficzne kości żuchwy. Analiza obrazów cyfrowych, przeprowadzona przy pomocy opracowanego programu komputerowego "Radiograph Workshop", wykazała, że u pacjentów z osteoporozą, w porównaniu z grupą kontrolną, obserwuje się znamienne zmniejszenie gęstości kości żuchwy, wyrażone mniejszym równoważnikiem zawartości minerałów (BMC), zmniejszoną gęstościa mineralną (BMD) oraz obniżeniem względnej gęstości kości żuchwy (BD). Analiza strutkury kości żuchwy wykazała w grupie chorych mniejszą niż w grupie kontrolnej liczbę beleczek radiolgoicznych (STN), zmniejszone zagęszczenie beleczek liczone w proc. powierzchni oraz większą niż u zdrowych szerokość radiolgoicznych beleczek żuchwy.

    Streszczenie angielskie: In a group of 130 patients with diagnosed osteoporosis and in 110 patients in control group radiovisiographic test of mandible bone structure had been carried out. Digital images analysis was carried out using Software Radiograph Workshop. It proved that in the group of patients with osteoporosis process in comparison with the control group there has been observed a significant deterioration of mandible bone density, defined as reduced bone mineral contents (BMC), reduced bone mineral density (BMC), and reduced mandible bone density (BD). Bone structure analysis showed in the control group of the treated patients with osteoporosis lower than in the control group quantity of structure of trabecular number (STN), deterioration of bone trabecular density expressed in p.c. of area and greater structure of trabecular width than that in healthy patients.


    2407/2523

    Tytuł oryginału: Effekt of age and gender on the condition of bone tissue of stomatognathic system.
    Tytuł polski: Wpływ wieku oraz płci na stan tkanki kostnej narządu żucia.
    Autorzy: Tomaszewski Tomasz, Czerwiński Edward
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.342-351, il., tab., bibliogr. 24 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: U 240 pacjentów w średnim wieku, meżczyzn 50,3 lat, kobiet 54,4 lat, leczonych w Klinice Chirurgii Stomatologicznej i Szczękowo-Twarzowej AM oraz w Poradni Osteoporozy Instytutu Medycyny Wsi w Lublinie, przeprowadzono badania radiowizjograficzne okolicy zębów przedtrzonowych po stronie lewej. Cyfrowy zapis obrazu rwg opracowano przy pomocy programu komputerowego Radiograph Workshop, a uzyskane wskaźniki gęstości i struktury kości żuchwy analizowano pod względem zależności od płci i wieku badanych. Stwierdzono, iż gęstość względna, gęstość mineralna oraz zawartosć minerałów w kości jest istotnie większa u mężczyzn niż u kobiet, a jednocześnie ulega istotnemu zmniejszeniu z wiekiem. Wiek i płeć badanych w mniejszym stopniu wpływa na radiolgoiczne wskaźniki struktury, uzyskane w wyniku analizy zdjęć RVG programem Radiograph Workshop.

    Streszczenie angielskie: The 240 patients, with the mean age 50.3 year for males and 54.4 years for females treated in the Department of Dental and Maxillofacial Surgery Medical University and Institute of Rural Medicine in Lublin had radiovisiographically tested premolar teeth area on the left hand body side. Digital radiovisiographical picture was developed using computer software Radiograph Workshop, and obtained factors of bone mineral density and mandible bone structure were reviewed with regard to gender and age of the treated. It was concluded that relatvive density, mineral density and bone mineral contents is significantly greater with male than female patients, and is deteriorating significantly with age. Age and gender of the treated in a lesser degree influences on radiological structure factors resulting from radiovisiographical picture analysis using Radiograph Workshop.


    2408/2523

    Tytuł oryginału: Influence of estrogen deficiency on the copper level in rat teeth and mandible.
    Tytuł polski: Wpływ niedoboru estrogenów na poziom miedzi w zębach i żuchwie szczura.
    Autorzy: Rahnama Mansur
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.352-356, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Na podstawie badań z użyciem atomowej spektrometrii absorpcyjnej określono poziom miedzi w zębach i żuchwie szczurów w przebiegu doświadczalnej osteoporozy pomenopauzalnej oraz po zastosowaniu 17á-estradiolu. Stwierdzono, że niedobór estrogenów prowadzi do obniżenia zawartości miedzi w zębach i żuchwie szczurów, a podawanie 17á-estradiolu wpływa w sposób korzystny na skład mineralny badanych tkanek.

    Streszczenie angielskie: On the basis of atomic absorption spectrophotometry rat teeth and mandible copper levels in experimetnal postmenopausal osteoporosis and after adminsitration of 17á-estradiol were measured. The resutls showed that estrogen deficiency leads to decrease in copper content in rat teeth and mandible, and giving of 17á-estradiol positively influence the content of mineral components in the examined tissues.


    2409/2523

    Tytuł oryginału: Results of Nd:YAG laser capsulotomy in posterior capsule opacification.
    Tytuł polski: Ocena leczenia zmętnienia tylnej torebki soczewki laserem Nd:YAG.
    Autorzy: Polak Monika, Żarnowski Tomasz, Zagórski Zbigniew
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.357-363, il., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Zmętnienie tylnej torebki jest jednym z najczęściej występujących powikłań po prawidłowo wykonanym zabiegu usunięcia zaćmy. Wynikiem zmętnienia jest znaczne pogorszenie się ostrości wzroku, jednakże obecnie nie ma żadnych metod zapobiegania wtórnemu zmętnieniu tylnej torebki. Kapsulotomia tylna jest jedną z najlepszych metod leczenia tego schorzenia. Przeprowadza się ją metodą chirurgiczną jak i przy użyciu lasera Nd:YAG. Celem pracy była ocena wyników zastosowania lasera neodymowego w zmętnieniu tylnej torebki soczewki. Analizie poddano 20 oczu u 23 pacjentów po zewnątrztorebkowym usunieciu zaćmy oraz po fakoemulsyfkacji z wszczepionymi sztucznymi soczewkami tylnokomorowymi. Wszystkie zabiegi wykonano przy użyciu lasera neodymowego typu Q-Swithc Zeiss. Poprawę ostrości wzroku uzyskaliśmy w 25 przypadkach (89 proc.). Ostrość wzroku rzędu 0,8 - 1,0 uzyskano w 72 proc. oczu, a u 22 proc. poprawiła się do 0,25 - 0,5. W dwóch przypadkach ostrość wzroku pogorszyła się z powodu współistniejącej jaskry. Natomiast u jednej pacjentki dwukrotna kapsulotomia nie przyniosła poprawy widzenia na skutek towarzyszącej neuropatii cukrzycowej n.II. W naszym materiale nie obserwowaliśmy powikłań opisywanych przez innych autorów: wzrostu ciśneinia wewnątrzgałkowego, torbielowatego obrzęku plamki, uszkodzenia sztucznej soczewki i zapalenia tęczówki. Kapsulotomia wykonana laserem Nd: YAG jest uważana obecnie za jedną z najlepszych metod leczenia zmętnienia tylnej torebki soczewki. Jest metodą skuteczną, bardziej bezpieczną i mniej inwazyjną w porównaniu z zabiegiem chirurgicznym oraz nie wymaga hospitalizacji chorych.

    Streszczenie angielskie: The most common postoperative complication of cataract extraction is posterior capsule opacification. It causes the deterioration of visual acuity, however, there is no effective method to prevent it. The posterior capsule opacification is treated by surgical or laser capsulotomy. The authors analysed the results of Nd:YAG application in discission of the opacified posterior capsule. Twenty-eight consecutive cases (23 patients) of extracapsular cataract extraction and phacoemulsification with implantation of posterior chamber intraocular lenses were reviewed. In all cases of capsulotomy the Nd:YAG laser of Q-switch Zesiss type was applied. The improvement of visual acuity was achieved in 25 cases (89 p.c.) The best visual acuity (0.8 - 1.0) was obtained in 72 p.c. of eyes and in 22 p.c. the improvement was from 0.25 to 0.5. In two cases visual acuity after capsulotomy deteriorated because of concomitant glaucoma. In one case repeated capsulotomy did not turn out to be successful. It was caused by diabetic neuropathy of the optic nerve. We did not observe any serious complications following Nd:YAG laser capsulotomy described by the others: the intraocular pressure elevation, cystoid macular edema, itnraocular lens injury, retinal detachment, iridocyclitis. Nd:YAG laser capsulotomy is one of the best methods of treatment of posterior capsule opacification. It appears to be effective, safe, non-invasive and it does not require patient hosptialisation.


    2410/2523

    Tytuł oryginału: Application of scintigraphy MDP 99 mTc in the diagnosis of osteoarticular pains of obscure etiology.
    Tytuł polski: Zastosowanie scyntygrafii MDP - 99 mTc w diagnostyce bólów stawowych o niejasnej etiologii.
    Autorzy: Samojłow Renata, Bojarska-Szmygin Anna, Asarabowski Jerzy, Wnuk Waldemar
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.364-369, il., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Scyntygrafia trójfazowa kości jest przydatna w wykrywaniu zaburzeń ukrwienia i metabolizmu tkanki kostnej u pacjentów z niejasną etiologią bólów stawowych. Scyntygrafia kości z zastosowaniem MDP pełni niewątpliwie nadal pierwszoplanową rolę w diagnostyce ortopedycznej. Największe znaczenie ma wtedy, gdy zdjęcia rengenowskie nie wykazują odchyleń od normy. Mimo stosowania innych nowoczesnych technik pozostaje metodą z wyboru we wczesnej diagnozie.

    Streszczenie angielskie: The three-phase scintigraphy of bones is useful in detecting disorders of bone tissue perfusion emtabolism in patients with the occult etiology of joint pains. The bone scintigraphy with application of MDP plays the main role in the orthopaedic diagnosis. It is of the greatest importance when radiograms are not normal. In spite of applicaiton of the other modern methods it is the technique of choice in the early diagnosis.


    2411/2523

    Tytuł oryginału: Urinary iodine excretion in inhabitans of rural region living in the Lublin Province.
    Tytuł polski: Wydalanie jodu w moczu u mieszkańców regionu rolniczego województwa lubelskiego.
    Autorzy: Borzęcki Andrzej, Borzęcka Halina, Zajączkowska Maria, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.370-374, tab., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Jod jest pierwiastkiem koniecznym do prawidłowego funkcjonowania organizmu człowieka. Jako mikroelement wchodzący w skład hormonów tarczycy, które regulują metabolizm komórkowy całego organizmu, dostarczany musi być w odpowiedniej ilości. Dobowe zapotrzebowanie organizmu człowieka na jod wynosi 150-300 ćg, jednak mimo suplementacji w wielu regionach Polski występuje endemicznie wole. Celem pracy jest ocena stężenia jodu w moczu u mieszkańców rejonu rolniczego jako prostej metody wykrywania niedoboru jodu w organizmie. Badania przeprowadzono u 132 mieszkańców wsi Majdan Nowy w województwie lubelskim w wieku od 9 do 74 lat (54 mężczyzn i 78 kobiet). Wioska położona jest w oddali od głównych dróg komunikacyjnych w regionie Roztocza. Większość badanych zamieszkuje ten region w tych samych warunkach od urodzenia. Stężenie jodu w próbce wyknywano u badanych z rannej porcji moczu. Poziom jodu oznaczano metodą Sandell-Kolthoffa, a odczyty przeprowadzano przy użyciu spektofotometru SPECOL firmy Carl-Zeiss, Jena. Uzyskane wyniki poddano analizie statystycznej za pomocą testu t-Studenta. Stwierdzono, że wielkość wydalania jodu z moczem u kobiet wzrastała wraz z wiekiem i była najwyższa w grupie badanych powyżej 40 roku życia. Średnia wartosć wskaźnika ilości wydalanego jodu/1g kreatyniny była istotnie wyższa w grupie III, zarówno w stosunku do grupy I (p 0,05), jak i do grupy II (p 0,01). Wydalanie jodu z moczem u mężczyzn w różnych grupach wiekowych kształtowało się na podobnym poziomie, a obserwowane różnice nie były statystycznie istotne...

    Streszczenie angielskie: Iodine is the element necessary for the human organism to function properly. Iodine is essential especially for the synthesis of thyroid hormones that regulate the cellular metabolism of the whole organism. The purpose of the work was to estimate the concentration of iodine in urine among the inhabitants of a typical agricultural region as a simple method of detecting deficiency of iodine in the human orgnaism. The biggest iodine excretion was observed in a group above 40 years of age. The amount of the excretion of iodine together with urine was similar among men and women up to 40 years old. Monitoring of iodine concentration in urine is a sensitivie marker of iodine deficiency in the human organism.


    2412/2523

    Tytuł oryginału: Leisure time acitivities in teenagers in urban and rural areas.
    Tytuł polski: Sposób wykorzystania czasu wolnego przez młodzież w mieście i na wsi.
    Autorzy: Borzęcki Andrzej, Nieradko Barbara, Gnaś Bogumiła, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.375-380, il., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Współczesne społeczeństwa dążą do maksymalnego skrócenia czasu pracy i nauki szkolnej. Środki masowego przekazu w coraz większym stopniu wpływają na życie wielu rodzin i pochłaniają czas wolny, szczególnie młodzieży. Mogą one działać dwojako: destruktywnie na rozwijające się organizmy lub przeciwnie - promować zachowania prozdrowotne. Z medycznego punktu widzenia czas wolny powinien być wykorzystany na relaks psychiczny i wysiłek fizyczny, w szczególności sport. Celem pracy była analiza oraz sposób wykorzystania czasu wolnego przez młodzież na wsi i w mieście. Jako metodę badawczą wybrano ankietę składającą się z pytań otwartych i zamkniętych. Przeprowadzono badanie w grupie 100 dzieci ze szkół podstawowych (50 z miasta i 50 ze wsi) w wieku 11-15 lat. Dzieci udzieliły odpoweidzi na pytania zawarte w ankiecie, dotyczące rozkładu zajęć w ciągu dnia. W dniach nauki szkolnej młdozież miejska spędzała czas wolny głównie w domu (oglądanie telewizji, czytanie, słuchanie muzyki, hobby). Młodzież wiejska natomiast spędza więcej czasu wolnego na aktywnych zajęciach sportowych na świeżym powietrzu. Pomoc w domu jako zajęcie w dni wolne od nauki szkolnej wymienia 42 proc. dzieci z miasta oraz 56 proc. dzieci ze wsi. Zdecydowanie różni się sposób spedzania ferii i wakacji przez obie badane grupy dzieci. 78 proc. młodzieży miejskiej i tylko 58 proc. wiejskiej deklaruje wyjazdy poza miejsce zamieszkania. Wnioski z przeprowadzonych badań przemawiają za mało aktywnym spędzaniem czasu wolnego przez dzieci w mieście, zbyt długim oglądaniem telewizji przez wszystkie ankietowane dzieci i niewielkimi możliwościami spędzania czasu wolnego poza miejscem zamieszkania przez dzieci wiejskie.

    Streszczenie angielskie: The work aimed to determine the leisure time activities in teenagers on weekdays, weekends, during winter and summer holidays. Vast majority of teenagers spend their leisure time resting in a passive way, i.e. watching TV or playing computer games irrespectively of the season. As a result of this, the number of kids with posture defects increase. On weekdays the country teenagers spend much more time doing outdoor sports and games than town children. They also more often help their parents and less frequently travel away from their homes than children living in towns.


    2413/2523

    Tytuł oryginału: Results of coronary arteries bypass grafting in patients over 70 years old.
    Tytuł polski: Pomostowanie tętnic wieńcowych u chorych po 70 roku życia - pierwszy rok doświadczeń.
    Autorzy: Stążka Janusz, Janiszewski Wawrzyniec
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.381-386, il., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Obecnie z powodu wzrostu średniego wieku społeczeństwa coraz większą grupę chorych wymagających rekonstrukcji krążenia wieńcowego stanowią osoby starsze, które ukończyły 70 lat. W Klinice Kardiochirurgii AM w Lublinie w roku 2000 wykonano 30 operacji CABG u chorych, którzy przekroczyli 70 rok życia. Operacje przeprowadzono przy wykorzystaniu krążenia pozaustrojowego. We wczesnym okresie pooperacyjnym zmarło 3 chorych, u 2 konieczne było zastosowanie mechanicznego wspomagania lewej komory (IABP). 2 pacjentów wymagało reoperacji w dobie zerowej z powodu nadmiernego drenażu. Zabiegi pomosotwoania tętnic wieńcowych u pacjentów po 70 roku życia obarczone są większym ryzykiem pooperacyjnym, wydłużonym okresem rekonwalescencji oraz wyższą śmiertelnością. W świetle przeprowadzonej analizy zdecydowana większość chorych w tej grupie wiekowej uzyskuje poprawę stanu zdrowia oraz jakości życia.

    Streszczenie angielskie: At present, according to the increase of average age in modern societies, the patients who are over 70 years old and require coronary arteries reconstruction constitute a constantly growing group. In the cardiosurgical Clinic of the Medical University of Lublin 30 coronary arterires bypass grafting operations in over 70-year-old patients were performed in 2000. The oeprations were performed using extra-body circulation. In the early postoperation period 3 patietns died (10 p.c.), 2 patietns (6 p.c.) required applying mechanical support of the left ventricle (IABP). 2 patietns (6 p.c.) needed reoperation because of excessive drainage in teh immediate postoperational period. CABG in patients over 70 years of age are connected with higher "perioperational" risk, prolonged recovering period and and higher mortality. According to the results of the survey, the overwhelming majority of patients at that age gets improvement in their health and in the quality of life.


    2414/2523

    Tytuł oryginału: Mercurialism in the material of the Regional Centre of Acute Poisonings of the Institute of Rural Medicine in Lublin.
    Tytuł polski: Zatrucia rtęcią w materiale Regionalengo Ośrodka Ostrych Zatruć Instytutu Medycyny Wsi w Lublinie.
    Autorzy: Brzeski Zdzisław, Złomaniec Janusz, Guz Wiesław, Krupski Witold
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.387-389, il., bibliogr. 8 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • neurologia
  • toksykologia
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie polskie: Na tle objawów klinicznych zatruć rtęcią przedstawiono przypadek zatrucia w celach samobójczych o pomyślnym przebiegu leczenia i dobrym rokowaniu. Podkreślono znaczenie toksycznego uszkodzenia nerek oraz różnorodnych objawów ze strony CUN.

    Streszczenie angielskie: Against the background of clinical symptoms of mercury posionings a case of suicidal poisoning which had favourable course and prognosis was presented. The impact of toxic renal damage and different CNS symptoms was emphasised.


    2415/2523

    Tytuł oryginału: Arteriovenous angiomas in pictures of digital subtractional angiography (DSA).
    Tytuł polski: Naczyniaki tętniczo-żylne w obrazach cyfrowej angiografii subtrakcyjnej (DSA).
    Autorzy: Piasecka Katarzyna, Krupski Witold, Jędrzejewski Grzegorz, Złomaniec Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.390-399, il., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W materiale 16 naczyniaków tętniczo-żylnych stwierdzanych w grupie 591 angiografii tętnic mózgowych przedstawiono wartość cyfrowej angiografii subtrakcyjnej. Analizowano uwidocznienie tętniczych naczyń zaopatrujących, masy naczyniowej, jądra i żył drenujących. Angiogramy korelowano z przekrojami kontrastowymi TK, odtwarzając współistniejące krwawienie śródmózgowe i podpajęczynówkowe. Porównano stopień uwidocznienia efektu masy w obu badaniach. Podkreślano wartość angiograficznego wykazania działania ssącego naczyniaków w tzw. zespołach podkradania.

    Streszczenie angielskie: The value of digital subtractional angiography (DSA) was presented in the material of 16 arteriovenous anigomas found in the group of 591 angiographies of cerebral arteries. Visualisation of arterial supplying vessels, vascular mass, nucleus and draining vessels was analyzed. Angiograms were correlated with CT contrast sections to reconstruct coexisting intracerebral and subarachnoid hemorrhages. The degree of visualization of mass effect in the two examinations was compared. There was emphasized the role of angiographic demonstration of the sucking effect of angiomas in the so-called stealing syndromes.


    2416/2523

    Tytuł oryginału: The acitvity of dental caries in students of the Faculty of Dentistry, the study with the use of microbiological and biochemical tests (Dentocult SM).
    Tytuł polski: Aktywność próchnicy zębów u studentów stomatologii. Badania z zastosowaniem testów mikrobiologicznych (Dentocult SM).
    Autorzy: Kiernicka Małgorzata, Bachanek Teresa, Klichowska-Palonka Małgorzata
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.400-406, il., tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem badań było określenie ryzyka próchnicy u studentów stomatologii za pomocą standardowych testów Dentocult SM i uzyskanie odpowiedzi na pytanie: czy można wykorzystywać testy Dentocult SM i uzyskanie odpowiedzi na pytanie: czy można wykorzystywać testy Dentocult SM do badań aktywności próchnicy w grupie wiekowej 20-25 lat? Materiał badawczy stanowiło 66 studentów oddziału stomatologii Akademii Medycznej w Lublinie. U wszystkich badanych dokonano oceny stanu uzębienia za pomocą średniej liczby PUW, PUWp i Pp. Do badań mikrobiologicznych wykorzystano gotowe podłoże wchodzące w skład zesawu Dentocult SM. W wyniku przeprowadzonych badań stwierdzono, że ryzyko wystąpienia próchnicy nie może być określone wyłącznie wartością liczby Streptococcus mutans.

    Streszczenie angielskie: The aim of the paper is to answer the question whether the Dentocult SM test could be used to study dental caries activity in the 20-25 age group. 66 students of the Faculty of Dentistry, Medical University of Lubin, were included in the study. In all cases dental state was assessed by using average numbers of DMF and DMFsDs. In the microbiological examinations a ready-made medium from Dentocult SM set was used. The resutls revealed that the risk of dental caries in the population studied cannot be determined only on the basis of Streptococcus mutans values.


    2417/2523

    Tytuł oryginału: General practitioners' opinions on the intake of painkillers among patients.
    Tytuł polski: Opinie lekarzy pierwszego kontaktu na temat spożycia leków przeciwbólowych przez pacjentów.
    Autorzy: Latalski Maciej, Skórzyńska Hanna, Pacian Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.407-412, bibliogr. 6 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy była ocena spożycia leków przeciwbólowych przez pacjentów na podstawie opinii lekarzy pierwszego kontaktu. W ich praktyce wśród stanów chorobowych przebiegających z dolegliwościami bólowymi dominowały przypadki z bólem przewlekłym (64,3 proc.), zdecydowanie rzadsze były ostre stany bólowe w przebiegu chorób (35,7 proc.). Ankietowani lekarze dostrzegają zjawisko nadużywania leków przeciwbólowych przez pacjentów przewlekle chorych. Niekontrolowane samoleczenie jest możliwe dzięki wciąż łatwej dostępności do tego typu leków. Nadmierne stosowanie w terapii leków analgetycznych wynika często z braku równoczesnego stosowania innych metod leczenia bólu, np. z zakresu fizkoterapii, psychoterapii. Ponad połowa badanych lekarzy (67,1 proc.) dostrzega negatywne konsekwencje w postaci uzależnienia od specyfików przeciwbólowych.

    Streszczenie angielskie: The goal of this paper is to evaluate the consumption of painkillers among patients on the basis of the opinions of general pracititioners. The most frequent ailments including pain symptoms were the cases of long-continued pain (64.3 p.c.); less frequent were acute pain syndromes in the course of a disease (35.7 p.c.). The phenomenon of the excessive use of painkillers among patients with long-continued pain syndromes is observed by the GPs. Uncontrolled self-treatment is possible owing to an easy access to this type of medicaments. The excessive use of analgesic medicines in therpay frequently results from the lack of simultaneous application of other methods of pain treatment e.g., in physiotherapy, psychotherapy. Long lasting use of various types of painkillers can lead to drug addiction. This problem is observed by over a half of the GPs (67.1 p.c.).


    2418/2523

    Tytuł oryginału: Long-term survival after bronchial sleeve resections.
    Tytuł polski: Odległe wyniki resekcji mankietowych drzewa oskrzelowego.
    Autorzy: Furmanik Franciszek, Czajkowski Marek, Sawicki Marek
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.413-420, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: W okresie od lutego 1990 r. do lutego 2000 r. wykonano w Klinice Chirurgii Klatki Piersiowej AM w Lublinie 53 resekcje anatomiczne tkanki płuca, połączone z resekcją mankietową drzewa oskrzelowego. Celem prezentowanego badania była analiza odległych wyników leczenia operacyjengo. Większość chorych (86,8 proc.) operowano z powodu niedrobnokmórkowego raka płuca (NDRP). Zanotowano 3 zgony okołooperacyjne (5,7 proc.). Mediana przeżycia dla wszystkich operowanych chorych wynosi 45,6 meisiąca, a dla 45 chorych operowanych z powodu NDRP 41,2 miesiąca. Skumulowany odsetek przeżyć 5-letnich w grupie chorych operowanych z powodu NDRP wyniósł 38,6 proc. Znamienny wpływ na czas ich przezycia miały: przedoperacyjny stan sprawności wg WHO oraz wystąpienie cechy N2 i nieradykalność resekcji. Wydaje się, że wobec zbliżonej skuteczności, ograniczonej liczby powikłań i zgonów okołooperacyjnych, a także korzyści czynnościowych resekcje mankietowe mogą być wykonywane zarówno ze wskazań czynnościowych, jak i anatomicznych w każdym kwalifikującym się do tego przypadku.

    Streszczenie angielskie: Between February 1990 and February 2000, 53 anatomical pulmonary tissue resections with sleeve bronchial resections have been performed in teh Department of Thoracic Surgery of Medical University of Lublin. The aim of the present study was the evaluation of long-term results of operative treatment. Most of the cases (86.8 p.c.) were patients with non-small cell lung cancer. Three perioperative deaths (5.7 p.c.) were recorded. The mean time of survival for all patietns was 45.6 months and for NSCLC patietns was 41.2 months. The cumulative 5 years' survival rate in cancer patients was 38.6 p.c. Preoperative performance status, presence of N2 and non-radical resection have been recognised as significant prognostic factors in cancer patients. In our opinion, in view of comparable efficacy, low morbidity, mortality and functional benefits pulmonary sleeve resections should be considered in every patient with favourable anatomical and functional conditions.


    2419/2523

    Tytuł oryginału: Causes and circumstances of injuries in children.
    Tytuł polski: Przyczyny i okoliczności urazów u dzieci.
    Autorzy: Borzęcki Andrzej, Łukawski Krzysztof, Robak Lucyna, Borzęcka Halina, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.421-425, tab., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • traumatologia i ortopedia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Problem urazowości wśród dzieci jest ciągle aktualny, a dane statystyczne potwierdzają tendencję wzrostową w ostatnich dziesięcioleciach. Celem pracy była ocena przyczyn i okoliczności urazów u dzieci w wieku od 7 do 15 lat, hospitalizowanych w Oddziale Chirurgicznym Wojewódzkiego Specjalistycznego Szpitala Dziecięcego w Kielcach w okresie od 30 VI 1997 do 30 VI 1998 roku. Retrospektywna analiza dokumentacji medycznej dotyczyła 768 pacjentów. Największa urazowość wystąpiłą w grupie wiekowej 10-12 lat (46 proc.). Zdecydowaną większość leczonych stanowili chłopcy. Najwięcej urazów nastąpiło w okresie letnim (33 proc.). W badanej populacji dominowały wypadki w domu (56 proc.). Na drugim miejscu były wypadki drogowe (18 proc.), a następnie urazy doznane w szkole (13 proc.) i w gospodarstwie rolnym (7 proc.). Urazy i wypadki przeważały wśród dzieci mieszkających na wsi (53 proc.).

    Streszczenie angielskie: The problem of the incidence of traumas among children is still topical and statistical data confirm an increasing tendency in the last decades. The purpose of the work was to estimate the causes and circumstances of injuries in children at the age of 7 to 15, who were admitted to Surgical Ward of Specialist Paediatric Hospital in Kielce between 30th June 1997 and 30th June 1998. A retrospective analysis of medical documentation concerned 768 patients. Our studies showed that the biggest number of injuries was related to children 10-12 years old (46 p.c.). The majority of patients were boys. Most injuries occurred in summer (33 p.c.). In the studied population dominant were accidents at home (56 p.c.) and then road accidents (18 p.c.), injuries at school (13 p.c.) and on farms (7 p.c.). Accidents and injriues occurred more often in children from the rural areas (53 p.c.).


    2420/2523

    Tytuł oryginału: Life style and the risk of development of circulatory system diseases.
    Tytuł polski: Styl życia a ryzyko rozwoju chorób układu krążenia.
    Autorzy: Borzęcki Andrzej, Żółkowska Dorota, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.426-432, tab., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie polskie: Celem pracy była próba oceny wpływu stylu życia na rozwój chorób układu krążenia. Badaniami objęto 86 pacjentów (41 proc. kobiet i 59 proc. mężczyzn) w wieku 30 do 70 lat, hospitalizowanych w Oddziale Kardiologii Samodzielnego Publicznego ZOZ-u Zarządu Służby Zdrowia MSWiA w Lublinie. U 27 proc. badanych przyczyną hospitalizacji była choroba wieńcowa serca, u 25 proc. nadciśnienie tętnicze, u 20 proc. miażdżyca naczyń, u 15 proc. zaburzenia rytmu serca, a u 13 proc. zawał mięśnia sercowego. Metodą badawczą była ankieta oraz analiza dokumentacji lekarskiej i pielęgniarskiej. Udział w badaniu był dobrowolny i anonimowy. Przeprowadzone badania wykazały, że 72 proc. badanych wystąpienie chorób układu krążenia wiąże z trudnymi warunkami życia codziennego i stresem. 30 proc. ankietowanych w sytaucjach stresowych radzi sobie sięgając po używki, 14 proc. zażywa leki uspokajające, a tylko 10 proc. badanych relaksuje się przez aktywność fizyczną. O sposobie odżywiania badanych decydują przyzwyczajenia i tradycje kulinarne, a nie czynniki zdrowotne. U 61 proc. pacjentów w codziennej diecie przeważają tłuszcze zwierzęce. Pomimo że u 65 proc. ankietowanych obserwowano nadwagę lub otyłość, tylko 8 proc. uważało ją za czynnik chorobotwórczy. Najbardziej rozpowszechnionym czynnikiem ryzyka wystąpienia chorób układu krążenia było palenie tytoniu, co dotyczyło aż 79 proc. badanych. Podkreślić należy że tylko 7 proc. palących uważa swój nałóg za przyczynę chorób układu krążenia. Kolejnym czynnikiem ryzyka jest spożywanie alkoholu...

    Streszczenie angielskie: Circulatory system diseases (c.s.d.) belong to the group of civilisation diseases. The risk factors of circulatory system diseases are: stress, overuse of alcohol, smoking cigarettes, bad eating habits, sitting life style. Calorie overconsumption, animal fat rich diet, sitting life style result in the development of android obesity, hypercholesterolemia, that enhance atheromatosis. The most dangerous consequences of atheromatosis are: angina pectoris, hypertension, myocardial infarction, brain insult, type II diabetes. The aim of the work was to evaluate life style and its correlation with development of circulatory system diseases. The results obtained significantly idicate how important is health education about the danger of widely understood unhealthy life style. Propagation of staying healthy model with emphasizing real profit resulting from leading healthy life style is the only righteous way to improve it.


    2421/2523

    Tytuł oryginału: Starting with the hospice/palliative care project - the philosophy and the practice.
    Tytuł polski: Hospicjum - projekt opieki paliatywnej - pomiędzy filozofią a praktyką.
    Autorzy: Krasuska Małgorzata E., Stanisławek Andrzej, Mazurkiewicz Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.433-438, bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem opieki paliatywnej jest maksymalizacja jakości życia chorych z przewlekłą, postępującą chorobą, a także ich rodzin oraz innych bliskich im osób. Opieka paliatywna posiada charakter interdyscyplinarny, a zarazem pacjentocentryczny. Posiada pięć wymiarów, z których pierwsze trzy: biologiczny, psychospołeczny i duchowy odnoszą się do sfery funkcjonowania osoby chorej, a dwa pozostałe: opieka nad rodziną i nad profesjonalnymi dawcami wsparcia - dotyczą opiekunów. Analizując rozwój opieki paliatywnej na przestrzeni ostatnich dwudziestu lat, zgłoszono postulaty na rzecz utrzymania harmonii pomiędzy szczytną filozofią a wymaganiami ze strony praktyki.

    Streszczenie angielskie: The goals of the palliative care is the maximizing of the quality of life of people with the chronic progressive illness, their families and those who care about them. The palliative care is characterized by the interdisciplinary and patient-centered approach which consists of five dimensions: the sphere of the biological, psycho-social and spiritual functioning centered on the patients life, and the others: the care for the family and care for ourselves concerned with the care for the caregivers. The authors describe the development of the palliative care in the last twenty years and stress the importance of the difficult but necessary balance-keeping between the philosophy, mission and the practical needs.


    2422/2523

    Tytuł oryginału: Palliative care professional education in the new millennium: global perspectives - universal needs.
    Tytuł polski: Kształcenie profesjonalne w zakresie opieki paliatywnej: globalne perspektywy - uniwersalne potrzeby.
    Autorzy: Krasuska Małgorzata E., Stanisławek Andrzej, Mazurkiewicz Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.439-443, bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Opieka paliatywna w XX wieku przybrała zdecydowanie anglosasko-chrześcijański charakter. Czy opieka nad będącym u schyłku życia przewlekle chorym i jego rodziną odzwierciedla w większości osiągnięcia zachodniej cywilizacji i kręgów judeochrześcijańskich, czy też w obliczu globalnej perspektywy może stanowić uniwersalny sposób na rozwiązanie wspólnych dla wszystkich ludzi problemów związanych ze śmiercią i umieraniem? Artykuł przedstawia możliwości kształcenia profesjonalnych przedstawicieli opieki paliatywnej w perspektywie międzynarodowej, z uwzględnieniem krajów rozwijających się, w taki sposób, ażeby sprostali oni również wyzwaniom innych religii oraz wyzwaniom transkulturowym.

    Streszczenie angielskie: In the 20th century, the palliative care is based mostly upon the Anglo-Saxon and Christian contemporary model of care. is such a model sufficient and could be transformed to the places outside of Judeo-Christian based, west civilization? Is such a model transcultural and could be used for problems solving for those who are professionally involved in the end-of-life care? The universal needs of the dying human being and the family are seen by the authors in the global perspective, and that perspective is tailored as a base for the transcultural model of the education for the professionals within the palliative care.


    2423/2523

    Tytuł oryginału: Surgical treatment in Paget's disease of the breast.
    Tytuł polski: Leczenie operacyjne choroby Pageta gruczołu piersiowego.
    Autorzy: Stanisławek Andrzej, Kurylcio Lucjan, Krasuska Małgorzata E.
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.444-448, tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: Zakres operacji w chorobie Pageta gruczołu piersiowego zależy od stopnia zaawansowania nowotworu oraz przeciwwskazań do leczenia oszczędzającego. Mimo coraz powszechniejszego sotoswania operacji z zaoszczędzeniem piersi w naszym materiale było ono niewielkie. Wykonaliśmy bowiem 29 mastektomii i tylko 6 operacji oszczędzających pierś. Bez względu na sposób leczenia przeżycia 5-letnie dla chorych z komponentą nieinwazyjną wyniosły 89,76 proc., a inwazyjną 49,32 proc.

    Streszczenie angielskie: The extent of the operation in Paget's disease of the breast depends largely on the degree of clinical advancement of neoplasm as well as counter-indications for breast conserving therapy. Despite the increasing use of breast conserving therapy, rather few such operations of this kind have been performed in our department. We have carried out 29 mastectomies and only 6 breast conserving operations. No matter what type of therapy was applied the percentages of 5-year survivals for the patients with non-invasive component and for the ones with invasive component were respectively 89.76 p.c. and 49.32 p.c.


    2424/2523

    Tytuł oryginału: The possiblities of surgical cover of skin defect in locally advanced breast cancer.
    Tytuł polski: Możliwości uzupełnienia ubytku po chirurgicznym leczeniu miejscowo zaawansowanego raka piersi.
    Autorzy: Stanisławek Andrzej, Kurylcio Lucjan, Kurylcio Andrzej, Krasuska Małgorzata E.
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.449-451, bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie polskie: Zastosowano trzy rodzaje chirurgicznego pokrywania ubytków skóry po leczeniu miejscowo zaawansowanego raka piersi, ponieważ pierwotne zszycie skóry było niemożliwe. W czterech przypadkach ubytek pokryto płatem skórno-mięśniowym opartym na mięśniu najszerszym grzbietu, z bardzo dobrym efektem. U dwóch chorych zastoswano przesunięty płat skórny z brzucha, a u jednej chorej zastosowano przeszczepy skórne pośredniej grubości. Kobiety przeżyły 2,1 lat przy znacznie wyższej jakości życia.

    Streszczenie angielskie: Three types of surgical procedure were applied to cover skin defect in locally advanced breast cancer after simple mastectomy. The skin defect was impossible for primary suture. In four cases we used latissimus dorsi myocutaneous flap with a very good effect. In two cases kin flap from the abdomen was used, and one case skin graft. The female patients survived 2.1 years with better quality of life.


    2425/2523

    Tytuł oryginału: Ultrastructural changes of pancreas of white rats after experimental administration of ethanol and cephalexin.
    Tytuł polski: Zmiany ultrastrukturalne trzustki szczurów białych po doświadczalnym podawaniu etanolu i cefaleksyny.
    Autorzy: Zarębska Alicja, Łańcut Mirosław, Sekita-Krzak Joanna, Visconti Józef, Czerny Krystyna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.452-458, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Badania wyknano na szczurach, samcach rasy Wistar o masie ciała ok. 200 g. Zwierzęta I grupy doświadczalnej otrzymywały 20 proc. etanol do picia (ad libitum), zwierzęta III grupy doświadczalnej - cefaleksynę w dawce 42 mg/24h, zwierzęta III grupy doświadczalnej - cefaleksynę i etanol w wymienionych dawkach. Po 10 dniach zwierzęta dekapitowano i pobierano trzustkę do badań w mikroskopie elektronowym. Stwierdzono, że 10-dniowe podawanie etanolu powoduje przede wszystkim zmniejszenie liczby rybosomów i ziaren zymogenu w komórkach egzokrynowych trzustki, natomiast cefaleksyna powoduje wzrost liczby tych struktur. Łączne podawanie alkoholou i cefaleksyny powoduje odwracalne zmiany degeneracyjne w postaci wyraźnego zmniejszenia liczby rybosomów, obrzmienia wielu mitochondriów i obecności w nich struktur mielinowych.

    Streszczenie angielskie: The experiment was carried out on WIstar rat males weighting about 200 g. Animals from experimental group I received 20 p.c. ethanol for drinking (ad libitum), animals from experimetnal group II - cephalexin in the dose of 42 mg/24h, animals from experimental group III - cephalexin and ethanol in the mentioned doses. After 10 days the animals were decapitated and pancreases were collected for ultrastural examinations in electron microscope. The performed experimetns showed that 10-day administration of ethanol causes mainly the decrease of amount of ribosomes and zymogen granules in pancreatic exocrine cells, whereas cephalexin causes increase of amount of these organelles. Administration of both ethanol and cephalexin causes reversible degenerative changes including distinct decreasing of the number of ribosomes, swelling of many mitochondria and the presence of myelinic structures inside cells.


    2426/2523

    Tytuł oryginału: Degenerative changes of the vertebral column in spatial imaging of 3D computed tomography.
    Tytuł polski: Zmiany zwyrodnieniowe kręgosłupa w obrazowaniu przestrzennym tomografii komputerowej 3D TK.
    Autorzy: Krupski Witold, Majcher Piotr, Krupski Mirosław, Fatyga Marek, Złomaniec Janusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.459-465, il., bibliogr. 14 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • radiologia
  • traumatologia i ortopedia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W grupie 36 chorych z bólowymi zespołami korzeniowymi dokonano oceny wartości diagnostycznej rekonstrukcji przestrzennej tomografii komputerowej (3D TK) w badaniach struktur kostnych kręgosłupa. Stwierdzono, że 3D TK jest techniką z wyboru w ocenie stenozy zwyrodnieniowej kanału kręgowego, powierzchni wewnętrznej kanału, zwężeń kostnych otworów międzykręgowych oraz zachyłków bocznych.

    Streszczenie angielskie: In a group of 38 patients with radicular pain syndromes diagnostic value of spatial reconstructions with computed tomography (3D CT) was assessed in examinations of bone structures of the vertebral column. It was found that 3D CT is a technique of choice in the assessment of degenerative stenosis of the vertebral canal, internal surface of the vertebral canal, bone narrowings of intervertebral foramens and lateral recesses.


    2427/2523

    Tytuł oryginału: Selected determinants of the quality of hospital care. P. 1: Accreditation and effectiveness of managing a therapeutic team.
    Tytuł polski: Wybrane determinanty jakości opieki w szpitalu.
    Autorzy: Sierpińska Lidia, Ksykiewicz-Dorota Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.466-472, tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie polskie: W celu zapewnienia wyższego poziomu jakości świadczeń medycznych wdrożono w polskich szpitalach zewnętrzny proces oceny zakładów opieki zdrowotnej, zwany akredytacją. Otrzymanie certyfikatu jakości przez szpital w dużym stopniu jest uzależnione od wiedzy i zaangażowania pracowników w proces akredytacyjny, a także efektywnego kierownaia zespołami terapeutycznymi przez ordyantorów oddziałów. Stąd postanowiono zbadać, jaka jest wiedza o posiadaniu certyfikatu jakości i jak oceniają efektywność kierowania zespołami terapeutycznymi lekarze i pielęgniarki ze szpitali z akredytacją i bez certyfikatu jakości. Badaniami objęto 560 lekarzy i pielęgniarek z 4 szpitali z akredytacją i 17 bez certyfikatu jakości. Metodą badawczą był sondaż diagnostyczny, zaś techniką kwestionariusz ankiety. Materiał poddano analizie statystycznej. Stwierdzono różnice istotne statystycznie w wiedzy o posiadaniu certyfikatu jakości wśród pracowników ze szpitali z akredytacją w porównaniu z badanymi z zakładów bez certyfikatu. Efektywność kierowania zespołami terapeutycznymi przez ordynatorów/kierwoników klinik niżej ocenili badani ze szpitali bez akredytacji.

    Streszczenie angielskie: In order to provide a higher level of the quality of medical services an external process of evaluation of health care units called accreditation has been implemented. Obtaining the Quality Certificate by a hosptial greatly depends on knowledge and engagement of the staff in the accreditation process as well as on the effective managing of therpaeutic teams by ward heads/managers of clincis. Therefore, studies wre undertaken to discover the knowledge of requirements concerning the possession of the Quality Certificate and how managing theraeputic teams is evaluated by physicians and nurses from hospitals with and without accreditation. The study covered 560 physicians and nurses from 4 hospitals with accreditation and 17 hospitals which did not possess the Quality Certificate. The research method was a diagnostic survey, and the technique - a questionnaire form. The material was subject to statistical analysis. Significant differences were observed in the knowledge of requirements concerning the possessing of the Quality Certificate between the staff of hosptials with accreditation, compared to the respondents from health units without the Quality Certificate. Respondents from hospitals without accreditation evaluated the effectiveness of managig therapeutic teams by ward heads/managers of clinics in more negative terms, compared to the staff of hosptials which possessed the Quality Certificate.


    2428/2523

    Tytuł oryginału: Selected determinants of the quality of hosptial care. P. 2: Managing a therapeutic team.
    Tytuł polski: Wybrane determinanty jakości opieki w szpitalu.
    Autorzy: Sierpińska Lidia, Ksykiewicz-Dorota Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.473-480, tab., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Efekty pracy w zespole w dużej mierze zależą od sprawności organizacyjnej kierownika. W zakładach opieki zdrwotnej za koordynację pracy zespołu terapeutycznego odpowiada lekarz-ordynator oddziału. Postanowiono sprawdzić, czy lekarze i pielęgniarki są świadome, że pracą zespołu terapeutycznego kieruje ordynator? Badaniu poddano 161 lekarzy oraz 339 pielęgniarek z 4 szpitali z akredytacją i 17 zakładów bez certyfikatu jakości. W badaniach zastosowano metodę sondażu diagnostycznego, zaś techniką był kwestionariusz ankiety. Wyniki badań wykazały, że znacznie częściej wyższą ocenę efektywności kierowania zespołem terapeutycznym ordynatorom/kierownikom klinik wystawiały pielęgniarki odcinkowe w szpitalach z akredytacją oraz ordynatorzy sobie w zakładach bez certyfikatu, zaś więcej ocen negatywnych podały pielęgniarki odcinkowe w zakładach bez akredytacji oraz więcej ocen negatywnych podały pielęgniarki odcinkowe w zakładach bez akredytacji oraz pielęgniarki oddziałowe ze szpitali z certyfikatem. Stwierdzono, że lekarze i pielęgniarki ze szpitali z akredytacją postrzegają istotnie statystycznie częściej w porównaniu z badanymi ze szpitali bez certyfikatu jakości, że ordynator oddziału kieruje praca zespołu terapeutycznego.

    Streszczenie angielskie: The effect of teamwork depend to a large extent on the organizational skills of the manager. It health care units a physician/ward head is responsible for coordinating the work of a therapeutic team. The study was undertaken to discover to what extent doctors and nurses are aware that the ward head manages the work of the therapeutic team, and how they evaluate the skills of their managers. The study covered 161 doctors and 339 nurses from 4 hospitals with accreditation and 17 health units which did not possess the Quality Certificate. The study was conducted by the method of diagnsotic survey, and the technique was a questionnaire form. The results of the survey showed that charge nurses in hospitals with accreditatin and ward heads in hospitals without the Quality Certificate significantly more often perceived the effectiveness of managing a therapeutic team by a ward head/manager of a clinic in positive terms. A greater number of negative evaluations were expressed by charge nurses in hospitals without accreditation and ward head nurses in hosptials with the Quality Certificate. It was confirmed that doctors and nurses from hospitals with accreditiation significantly more frequenty perceived the ward head as the manager of the therapeutic team, compared to the staff of hosptials without the Quality Certificate.


    2429/2523

    Tytuł oryginału: Selected determinants of the quality of hospital care. P. 3: Scope of duties, authorization and responsibility among members of a therapeutic team.
    Tytuł polski: Wybrane determinanty jakości opieki w szpitalu.
    Autorzy: Sierpińska Lidia, Ksykiewicz-Dorota Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.481-488, il., tab., bibliogr. 9 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Istotnym warunkiem efektywnie pracującego zespołu jest podział kompetencji wśród członków grupy. Kryteria akredytacyjne dla polskich szpitali stawiają wymóg sformułowania pisemnego zakresu obowiązków, uprawnień i odpowiedzialności na poszczególnych stanowiskach pracy. Warunkuje to wysoki poziom usług świadczonych przez członków zespołu terapeutycznego. Postanowiono sprawdzić, czy istnieje jednoznaczny podział kompetencji i czy ma on wpływ na poziom realizacji zakresu obowiązków, uprawnień i odpowiedzialności wśród członków zespołu terapeutycznego w oddziałach szpitalnych. Badaniami objęto 55 ordynatorów i kierwoników klinik, 72 pielęgniarki oddziałowe, 106 lekarzy asystentów i 327 pielęgniarek odcinkowych z 21 szpitali. Pracowali oni w 4 szpitalach z certyfikatem jakości i w 17 szpitalach bez akredytacji. Badania przeprowadzono metodą sondażu diagnostycznego, techniką był specjalnie skonstruowany kwestionariusz ankiety. Wyniki analizy porównawczej wykazały, że wśród członków zespołu terapeutycznego w szpitalach z certyfikatem jakości występuje istotnie częściej podział kompetencji zawodowych. Większość tej grupy badanych posiada zakresy obowiązków, uprawnień i odpowiedzialności na piśmie w porównaniu z lekarzami i pielęgniarkami ze szpitali bez akredytacji. Stwierdzono również, że najczęstszy brak zakresu obowiązków na piśmie oraz największa rozbieżność w realizacji zadań zawodowych występowała wśród członków zespołu terapeutycznego w szpitalach klinicznych bez ...

    Streszczenie angielskie: An important precondition for an effectively working team is the distribution of competence among the members of the team. The accreditation criteria for Polish hosptials lay down a requirement concerning the formulation in a written form of the scope of duties, authorization and responsibility at individual workplaces. This conditions a high level of services provided by the members of a therapeutic team. Therefore, the study was udnertaken in order to discover whether there was an explicit share of competence and if it exerted an influece on the level of performance of the scope of duties, authorization and responsibility among members of therapeutic teams in hospital wards. The study covered 55 ward heads/ managers of clinics, 72 ward head nurses, 106 assistant doctors and 327 charge nurses from 21 hospitals, who were employed in 4 hospitals which possessed the Queality Certificate, and in 17 hospitals without accreditation. The study was conducted by the method of a diagnostic survey, the technique being a questionnaire form. The results of comparative analysis showed that among members of therapeutic teams in hospitals with the Quality Certificate the distribution of occupational competence was significantly more often observed. The greatest number of respondents in this group possessed the scope of duties, authorization and responsibility in a written form, compared to physicians and nurses from hospitals without accreditation. Moreover, it was confirmed that ...


    2430/2523

    Tytuł oryginału: Fatal intracranial hemorrhage after double valve replacement in infective endocarditis.
    Tytuł polski: Zgon spowodowany krwiakiem śródczaszkowym po wymianie dwóch zastawek serca z powodu zapalenia wsierdzia.
    Autorzy: Stążka Janusz, Czajkowski Marek
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.489-492, il., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie polskie: Zapalenie wsierdzia jest jednostką chorobową występującą rzadko, lecz obarczoną dużym ryzykiem powikłań ze zgonem włącznie. Powikłania zapalenia wsierdzia mogą dotyczyć różnych narządów. Powikłania najczęściej dotyczą serca, ale także pozostałych narządów - układu moczowego, nerwowego, naczyniowego. W pracy przedstawiono przypadek 31-letniego mężczyzny z dwudziestoletnim wywiadem kombinowanej wady mitro-aortalnej, z trwającymi trzy tygodnie objawami zapalenia wsierdzia. Mimo intensywnego leczenia zachowawczego stan pacjenta ulegał stałemu pogorszeniu. Pacjent poddany został zabiegowi operacyjnemu wszczepienia protezy zastawki mitralnej i aortalnej. W przebiegu pooperacyjnym u pacjenta rozwinął się zespół małego rzutu, niewydolność nerek z koniecznością hemofiltracji, niewydolność oddechowa. W dwudziestej piątej dobie po zabiegu operacyjnym pacjent był reoperowany z powodu narastającej niewydolności serca związanej z narastającym przeciekiem okołozastawkowym w obrębie zastawki mitralnej w przebiegu zapalenia wsierdzia (wymiana protezy zastawki mitralnej z pozostawieniam protezy zastawki aortalej). Pacjent zmarł w dziewiątej dobie po reoperacji wśród objawów niewydolności krążenia i krwiaka śródczaszkowego z obrzękiem mózgu.

    Streszczenie angielskie: Endocarditis is a life-threatening disease, although it is relatively uncommon. The complications of infective endocarditis may involve any organ system. Cardiac and extracardiac complications including neurologic, vascular and renal diseases are common and are usually caused by either embolization of vegetation or immune complexes. This case report presents a 31-year-old male with combined mitro-aortic valves defect and infective endocarditis on mitral valve. The replacement of mitral and aortic valves prosthesis were performed. During postoperative period low output heart failure, renal failure and respiratory failure developed. 25 days after the first operation the reoperation was performed because of mitral prosthesis insufficiency and thrombus just under the valve. On 31st day after the first operation patient died because of subdural hematoma and acut ecerebral oedema and encephalomalatia.


    2431/2523

    Tytuł oryginału: Benign prostatic hyperplasia, prostate cancer and other prostate diseases diagnosed as a result of screening procedure among 1,004 men in the Lublin district.
    Tytuł polski: Łagodny rozrost prostaty, rak prostaty oraz inne choroby stercza w badaniu przesiewowym 1004 mężczyzn z województwa lubelskiego.
    Autorzy: Opalińska Edyta, Stoma Filip, Michalak Anna, Latalski Maciej, Goniewicz Mariusz
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.493-501, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płeć męska

    Streszczenie polskie: Wraz z wiekiem choroby gruczołu krokowego, takie jak łagodny rozrost prostaty, rak prostaty i inne, stają się poważnym problemem dla mężczyzn. Rak prostaty jest najczęstszym nowotworem złośliwym u mężczyzn, druga pod względem częstości przyczyną zgonów spwodowanych nowotworem. Podejmuje się więc starania, aby zidentyfikować meżczyzn obciążonych wyższym niż przeciętne ryzykiem zachorowania. Temu służą badania przesiewowe, do których zalicza się między innymi badanie per rectum oraz oznaczenie markerów, takich jak specyficzny antygen sterczowy PSA. Celem pracy była ocena wstępnie postawionego przez lekarzy urologów rozpoznania choroby gruczołu krokowego w badaniu przesiewowym 1004 mężczyzn z województwa lubelskiego, zgłaszających się do Przyklinicznej Poradni Urologicznej w r. 2000. Pacjenci po zebraniu wywiadu poddani byli badaniu fizykalnemu, w tym badaniu per rectum. Mężczyźni, u których podejrzewano raka prostaty, zostali skierowanie na oznaczenie PSA we krwi. W badaniach uwzględniono miejsce zamieszkania i wiek pacjentów. Najczęściej stawianą wstępną diagnozą był łagodny rozrost prostaty, który dotyczył 77,1 proc. badanych, przeważnie w wieku 51-70 lat. Raka prostaty podejrzewano u niewielkiej grupy mężczyzn (3,5 proc.). Ze względu na to, że częstość rozpoznania łągodnego rozrostu prostaty oraz podejrzenia raka prostaty zwiększały się wraz z wiekiem badanej populacji, wydaje się celowe wykonywanie badań przesiewowych u mężczyzn powyżej 50 rok u życia.

    Streszczenie angielskie: Urological problems especially connected with prostate diseases apper in older men: prostatitis, benign prostatic hyperplasia, prostate cancer and others. Prostate cancer is the most common cancer in men and the second leading cause of deaths in male population. Therefore, it seems important to early detect prostate cancer in general practice seeting due to screening procedures such as digital rectal exam and prostate-specific-antigen test. The aim of the study was to examine the character of diagnoses of a prostate disease among 1,004 men of the Lublin district who reported to a doctor during screening procedure carried out in urology outpatient clinic at Clinical Hospital in Lublin in the year 2000. After physical examination urologists initially diagnosed a prostate disease and sent men suspected to have a prostate cancer to further investigations. There was studied age and place of living. Benign prostate hyperplasia was the most common diagnosis made in 77.1 p.c. of subjects. It occurred most often in men aged 51-70 years. Prostate cancer was suspected in 3.5 p.c. of subjects. Frequency of benign prostate hyperplasia and prostate cancer suspicion increased with age. On the basis of studies screening procedures seem beneficial in the early deteciton of prostate cancer in men over 50.


    2432/2523

    Tytuł oryginału: Objective assessment of self-care and non-professional care: a proposal.
    Tytuł polski: Propozycja zobiektywizowanego oceniania samoopieki i opieki nieprofesjonalnej.
    Autorzy: Zarzycka Danuta
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.502-512, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: We współczesnym pielęgniarstwie, jak i jego rozumieniu na poziomie teoretycznym i praktycznym, obok profesjonalnej opieki pielęgniarskiej znaczące miejsce zajmuje samoopieka i opieka nieprofesjonalna, co ma swoje odzwierciedlenie również w założeniach filozoficznych pielęgniarstwa polskiego. Zainteresowanie rodzimego pielęgniarstwa samoopieką i opieką nieprofesjonalną, a w konsekwencji teroią D. Orem oraz próby ich wdrożenia do praktyki pielęgniarskiej, jak również wynikające stąd trudności, stały się inspiracją do opracowania narzędzia służącego obiektywizacji ocen w tych obszarach. Autorska wersja Skali Wydolnosci Pacjenta i Opiekuna (SWPiO) stwarza możliwość zobiektywizowanej oceny wskaźnika samoopieki w postaci wydolności samoopiekuńczej pacjenta oraz wskaźnika opieki nieprofesjonalnej - wydolności opiekuńczej głównego opiekuna, wyrażonych w wartościach punktowych. Celem pracy jest zaprezentowanie Skali Wydolności Pacjenta i Opikuna oraz ocena jej wybranych właściwości psychometryczny, tj. rzetelności i trafności kryterialnej. WYniki badań, zmierzające do weryfikacji SWPiO głównie w wymiarze statystycznym, pozwalają sądzić, iż jest to narzędzie precyzyjnie badające zagadnienie wydolności samoopiekuńczej pacjenta i wydolności opiekuńczej opiekuna.

    Streszczenie angielskie: Nursing care today, both in theory and practice, consists not only of professional care rendered by nurse but, to a significant degree, involves also self-care and non-professional care. This tendency is also reflected in the philosophical premises of Polish Nursing. The interest in self-care and on-professional care in Poland, and, consequently, in the D. Orem's self-care deficit theory of nursing, as well as attempts at their implementation in nursing practice inspired the present attempt to develop a tool for objective assessment of these two types of care. The proposed Scale of Patient's and Care Provider's Agency (SPCPA) allows for the objective assessment of self-care as patient's self-care agency, and of non-professional care as the main care provider's agency measured in points. The aim of this study is to describe the tool and to assess its two psychometric properties: reliability and validity. The results of the statistical testing of the SPCPA show that the tool is capable of assessing precisely both the patient's self care agency and of the main provider's caring agency.


    2433/2523

    Tytuł oryginału: Caring in nursing - conditioning of realisation.
    Tytuł polski: Opiekuńczość w praktyce pielęgniarskiej - uwarunkowania realizacji.
    Autorzy: Ślusarska Barbara
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.513-521, il., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • pielęgniarstwo

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Opiekuńczość wyrażająca się w trosce pielęgniarki, pieczołowitości i staranności działań w odniesieniu do człowieka potrzebującego - stanowi istotę opieki pielęgniarskiej, a działalność opiekuńcza najbardziej samodzielny zakres aktywności pielęgniarki. Celem pracy było określenie, czy pielęgniarki w swojej praktyce zawodowej rozumieją istotę działalności opiekuńczej oraz czy dostrzegają uwarunkowania jej realizacji. Grupę badanych stanowiło 130 pielęgniarek zatrudnionych w placówkach zamkniętej opieki zdrowotnej. Badania przeprowadzono przy pomocy kwestionariusza ankiety, zawierajacego pytania o zróżnicowanej konstrukcji. Wyniki badań wskazują na to, że pielęgniarki częściej podejmują działania opekuńcze chętnie aniżeli bardzo chętnie oraz wraz ze wzrostem stażu pracy odsetek osób podejmujących czynności opiekuńcze zwiększa się w kategorii oceny bardzo chętnie. W badanej grupie pielęgniarek ponad 86 proc. osób samodzielnie podejmuje działania opiekuńcze, gdy tylko rozpozna występowanie zapotrzebowania na nie u pacjenta, jednakże w opinii tylko ponad 7 proc. respondentów działania opiekuńcze przeświadczają o odrębności zawodu pielęgniarskiego. Czynnikami determinującymi jakość świadczeń opiekuńczych w opinii największego odsetka badanych były: organizacja pracy w oddziale, wyposażenie w materiały i środki do pielęgnacji, czynniki osobowościowe i motywacja do pracy oraz wymagania stawiane przez zwierzchnika. Pielęgnairki pracujące metodą indywidualnej pracy z pacjentem ...

    Streszczenie angielskie: Caring manifested by the concern of a nurse, attention and carefulness of activities with respect to a human being in need is the essence of nursing care, while caring actions constitute the most independent scope of nurses' activities. The aim of the study was to determine whether the nurses in their everyday occupational practice understand the core of caring actions and perceive the conditioning of their realisation. The study covered 130 nurses employed in inpatient health facilities. The survey was conducted by means of a questionnaire form containing variously constructed questions. The results of the study showed that nurses undertook caring actions 'willingly' more often than 'very willingly', the percentage of respondents undertaking caring actions in category 'very willingly' increasing with the duration of employment. Over 86 p.c. of nurses in the study independently undertook caring actions, as soon as they recognized patietns' demand; however, only 7 p.c. of respondents admitted that caring actions determine the distinct character of the nursing profession. According to the greatest number of respondents the following factors determined the quality of caring services: organization of work in the ward, provision of material and means for nursing, personality-related factors, incentives for work, and supervisor's requirements. Nurses applying the mehtod of individual work with a patient undertook caring actions mre often than those working by the method of ...


    2434/2523

    Tytuł oryginału: Allergy to house dust mites in primary health care subjects with chronic or recurrent inflammatory states of respiratory system.
    Tytuł polski: Alergia na roztocza kurzu domowego u pacjentów podstawowej opieki zdrowotnej z przewlekłymi i nawracającymi stanami zapalnymi układu oddechowego.
    Autorzy: Paszkowski Jacek, Łopatyński Jerzy
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.522-530, il., tab., bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • immunologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem badania była ocena częstości występowania alergii na roztocza kurzu domowego jako przyczyny stanów zapalnych dróg oddechowych u pacjentów podstawowej opieki zdrowotnej. Przedmiotem obserwacji były również czynniki ryzyka alergii układu oddechowego. Zbadano 89 osób w wieku 3-47 lat. Na podstawie formularza ankietowego zbierany był wywiad alergologiczny, a w przypadku dzieci dodatkowo wywiad położniczy oraz informacje o przebytych chorobach i odżywianiu w pierwszym roku życia. U badanych osób wykonano uczuleniowe testy skórne z pospolitymi alergenami wziewnymi, pobierano krew celem oznaczenia poziomu IgE całkowitych i specyficznych na alergeny roztoczy oraz oznaczono stężenie alergenu roztoczy w próbkach kurzu dostarczonego z domu. Proponowano udział w badaniu krewnym pierwszego stonia badanych osób. Zbadano 30 pełnych rodzin. U członków rodzin, oprócz wywiadu i testów skórnych, oznaczano poziom IgE całkowitych i w określonych przypadkach także poziom IgE specyficznych. W badanej grupie 89 pacjentów stwierdzono alergię na roztocza kurzu domowego u 24 osób (27 proc.). Przewlekły nieżyt nosa, nawracające zapalenia oskrzeli, przewlekły i napadowy kaszel, napady świszczącego oddechu i duszności częściej występowały u osób z alergią. Na podstawie samego wywiadu stwierdzono prawie dwukrotnie częstsze występowanie alergii u krewnych pierwszego stopnia badanych alergików (25 proc.) w porównaniu z osobami bez alergii (13,8 proc.). Po przeprowadzeniu badań alergologicznych ...

    Streszczenie angielskie: Chronic and recurrent respiratory tract disorders are a frequent problem in general practice. The purpose of the study was to investigate the role of hypersensitivity to house dust mites in respriatory tract diseases in general practice patients. We tried to assess the influence of determined risk factors exposure on development of respiratory tract allergy. Patients from family practitioners surgeries with chronic or recurrent respiratory tract symptoms who had no diagnosis of allergy were recruited to the study (n=89). All patients responded to a questionnaire focused on history of symptoms, atopic conditions in family and exposure to determined environmental factors like dwelling conditions, obstetrician history, diet in the first year of life. All patients underwent skin prick test with common inhalant allergens. Families of the patients were asked to participate in the study. Families who agreed to take part also responded to the questionnaire and underwent skin tests. In patients and their families blood samples were taken to determine total IgE and specific IgE antibodies to mites allergens. Dust samples were collected by vacuuming of paitents' bedroom carpets and mattresses to determine house dust mites allergens concentration. Data on 30 complete patients family sets of their brohterhood, mother and father were collected. Total and specific serum IgE antibiodes were determined by disc enzymeimmunoassay (Analco). Mites allergens concentration in dust was ...


    2435/2523

    Tytuł oryginału: Sleeping disturbances and pharmacological/nonpharmacological interventions in old people.
    Tytuł polski: Zaburznia snu u osób w podeszłym wieku - leczenie farmakologiczne i niefarmakologiczne.
    Autorzy: Pia Wurtzen Norup
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.531-534, bibliogr. 2 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia
  • toksykologia
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Zaburzenia snu to poważny problem występujący u 25 proc. osób powyżej 65 roku życia. Wśród najczęstszych przyczyn bezszenności możemy wymienić nadużywanie kawy, alkoholu, palenie, niektóre leki, stres, depresję, nerwicę, demencję, choroby przewlekłe. Bezsenność idiopatyczna stanowi mniej niż 5 proc. przypadków. Podejmując leczneie bezsenności, należy ustalić jej przyczynę oraz określić, czy jest ona przejściowa, czy przewlekła. W leczeniu bezsenności stosuje się metody niefarmakologiczne i farmakologiczne. Wśród metod niefarmakologicznych wymienia się terapię behawioralną dotyczącą zmian nawyków związanych ze snem. Leczenie farmakologiczne (nadal najczęściej stosuje się preparaty benzodwuazepin) nie powinno trwać dłużej niż 2-3 tygodnie i stosowane powinny być prparaty o krótkim czasie półtrwania (poniżej 6 godzin). Trzeba zawsze mieć na uwadze efekty uboczne tej grupy leków. Należy pamiętać, że zaburzenia snu mogą być objawem innych schorzeń, a leczenie nie może polegać jedynie na przepisywaniu leków nasennych.

    Streszczenie angielskie: Sleeping disturbance constitutes a mjor problem occurring in 25 p.c. of people aged over 65. Among the most frequent reasons of insomnia one can mention the overuse of coffee, alcohol, smoking, using some drugs, stress, depression, neurosis, dementia, chronic diseases. Idiopathic insomnia constitutes less than 5 p.c. of cases. Before the treatment of insomnia is started, its cause should be found and it should be determined if it is transient or chronic. The treatment of insomnia can be based on pharmacotherapy and non-pharmacotherapy methods. Behavioural therapy is mentioned among non-pharmacotherapeutic methods. It aims at changing the sleep-related habits. Pharmacotherapeutic treatment (still mostly based on benzodiazepines) should not last longer than 2-3 weeks and drugs of short elimination T1/2 (below 6 hours) should be used. Side-effects of this group of drugs should always be taken into consideration. It should be remembered that sleep disturbances can be symptoms of other diseases and their treatment cannot consist in prescribing hypnotics only.


    2436/2523

    Tytuł oryginału: Primary health care and geriatric medicine in Denmark.
    Tytuł polski: Podstawowa opieka zdrowotna a medycyna geriatryczna w Danii.
    Autorzy: Hendriksen Carsten
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.535-539, streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: W Danii, liczącej 5,1 miliona mieszkańców, 15 proc. stanowią ludzie powyżej 65 roku życia i tak jak w większości krajów Europy odsetek ludzi w podeszłym wieku wzrósł w ciągu ostatnich lat. W pracy przedstawiony został model opieki geriatrycznej w Danii. Opisany został w skrócie duński system opieki zdrowotnej w aspekcie opieki nad ludźmi starymi. Omówiono również warunki życia ludzi starszych i świadczenia opiekuńczo-zdrowotne, jakie mogą mieć zapewnione osoby w podeszłym wieku w Danii.

    Streszczenie angielskie: In Denmark with its population of 5.1 million, 15 p.c. of inhabitants are people aged over 65 and - just like in ohter European countries - the percentage of elderly people has increased in the recent years. A model of geriatric care in Denmark was presented in this study. The Danish health care system has been briefly described in respect of the care for the elderly. Life conditions of the elderly people in Denmark as well as social and health care services provided for them were discussed.


    2437/2523

    Tytuł oryginału: Diagnosis, treatment and registration of urinary tract infections in geriatric patients.
    Tytuł polski: Diagnostyka, leczenie i rejestracja infekcji układu moczowego u pacjentów w podeszłym wieku.
    Autorzy: Friis-Moller Alice, Lneborg-Nielsen Margrethe
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.540-543, streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Bakteriuria (ň10**5 CFU/ml) jest zjawiskiem bardzo powszechnym u osób w podeszłym wieku, dwukrotnie częściej występującym u kobiet niż u mężczyzn. Rozróżnia się bakteriurię bezobjawową i objawową. Czynnikami ryzyka są: spadek poziomu estrogenów u kobiet po okresie przekwitania, cewnikownaie, dysfunkcja pęcherza moczowego, przerost prostaty, cukrzyca, choroby neurologiczne. Diagnostyka bakteriurii opiera sie na ilościowych posiewach moczu (wynk pozytywny ň 10**5 CFU/ml bakterii). Njaczęstszymi patoegnami są: E. coli, enterokoki, stafylokoki, Pseudomonas aeruginosa, Proteus mirabilis. Nie zaleca się antybiotykoterapii przy bakteriurii bezobjawowej. W przypadku bakteriurii objawowej zaleca się pobranie moczu do posiewu i oznaczenie wrażliwości bakterii oraz dodatkowo wykonanie posiewu krwi i rozpoczęcie "terapii empirycznej". Aby skutecznie stosować antybiotykoterapię, należy rozpoznać najczęściej występujące patogeny na danym obszarze i ich antybiotykowrażliwość.

    Streszczenie angielskie: Bacteriuria (ň 10**5 CFU/ml) is a very common phenomenon in elderly people, occurring twice as frequently in women than in men. THere are symptomatic and asymptomatic types of bacteriuria. Risk factors include: a decrease in the estrogen level in women after the menopause, catheterisation, urinary bladder dysfunction, hypertrophy of the prostate gland, diabetes, neurological illnesses. The diagnosis of bacteriuria is based on quantitative urine culture (positive result - ň10**5 CFU/ml bacteriae). The most frequent pathogens are: E. coli, enterococci, staphylococci, Pseudomonas aeruginosa, Proteus mirabilis. The antimicrobial therapy is not advised for asymptomatic bacteriuria. In the case of symptomatic bacteriuria it is advised to take urine for culture and to perform sensitivity testing as well as blood culture and to start a "blind therapy". In order to use the antimicrobial treatment effectively, the most frequently occurring pahtogens should be registered and their sensitivity patterns in the given hospital recognised.


    2438/2523

    Tytuł oryginału: Type 2 diabetes mellitus - a multifactorial disease.
    Tytuł polski: Cukrzyca typu 2 - choroba wieloczynnikowa.
    Autorzy: Hansen Torben
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.544-549, bibliogr. 11 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Cukrzyca typu 2 jest chorobą wieloczynnikową, u której podłoża leżą zarówno oligo- i poligeniczne czynniki genetyczne, jak i czynniki niegenetyczne, będące wypadkową braku równowagi między poborem i zużyciem energii oraz innych czynników związanych ze stylem życia. Ostatnie ustalenia ADA i WHO dokonały reklasyfikacji cukrzycy zarówno pod względen stadiów klinicznych, jak i etiologii. Istnieje już wiele danych dotyczących genetyki cukrzycy typu 2. Jednak wiele genów i związanych z nimi metabolitów oraz interakcje miedzy nimi a środowiskiem na poziomie molekularnym, komórkowym, tkankowym i całego organizmu pozostają nadal nieznane. Zmiany w częstości występowania cukrzycy w różnych miejskich i wiejskich populacjach i grupach etnicznych wykazują związek z przechodzeniem na zachodni styl życia. Zrozumienie patogenezy cukrzycy jest niezbędne w rozwoju nowych metod leczenia i strategii skutecznej prewencji tej choroby.

    Streszczenie angielskie: Type 2 diabetes is a multifactorial disease caused by both oligo- and polygenic genetic factors as well as non-genetic factors that result from a lack of balance between the energy intake and output and other life style related factors. ADA and WHO have recently reclassified diabetes on both clinical stages and aetiological grounds. There is a lot of data releated to the genetics of type 2 diabetes. However, many genes and gene products as well as their interactions with the environment at the molecular, cellular, tissue, and the whole organism levels are still unknown. Changes in the frequency of diabetes occurrence in various urban and rural populations and ethnic groups prove the relationship with the transition to the 'western' life style. Understanding of diabetes pathogenesis is essential to the development of new methods of treatmetn and strategies of effective prevention of this disesase.


    2439/2523

    Tytuł oryginału: Primary and specialist diabetes care three years after introduction of health care system reform in Poland.
    Tytuł polski: Podstawowa i specjalistyczna opieka diabetologiczna po trzech latach od wprowadzenia reformy ochrony zdrowia w Polsce.
    Autorzy: Mardarowicz Grażyna, Łopatyński Jerzy
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.550-555, tab., bibliogr. 12 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Autorzy omawiają epidemię cukrzycy na świecie i w Polsce. Na Lubelszczyźnie wykryli cukrzycę typu 2 (DM 2) u 15,6 proc. badanych powyżej 35 roku życia (według kryteriów WHO z roku 1985). Reforma ochrony zdrowia w Polsce utrudniła dostęp chorego do specjalisty zajmującego się leczeniem cukrzycy, dlatego lekarze i pielęgniarki podstawowej opieki zdrowotnej (POZ) stali się bardziej niż dotychczas odpowiedzialni za opiekę diabetologiczną. Za sprawę bardzo ważną autorzy uważają systematyczne kształcenie lekarzy POZ przez specjalistów, tak aby mogli leczyć według nowoczesnych standardów diabetologii praktycznej, jak również podział zadań i obowiązków pomiędzy podstawową i specjalistyczną opiekę diabetologiczną. Do POZ należałoby zapobieganie i wczesne rozpoznawanie DM 2, a także zapobieganie i wczesne wykrywania odległych powikłań tej choroby. Do specjalistów należałoby konsultowanie chorych w chwili diagnozy i potem przynajmniej raz w roku, również wczesne poszukiwanie i rozpoznawanie odległych powikłań cukrzycy. W POZ leczono by nadal większość chorych z DM 2, zaś w ośrodkach specjalistycznych większość chorych z cukrzycą typu 1, pacjentów z komplikacjami i chorych z grup specjalnego ryzyka (np. chore z cukrzycą ciążową).

    Streszczenie angielskie: The authors discuss epidemics of diabetes in the world and in Poland. In the Lublin region (eastern Poland), for instance, they found type 2 diabetes (DM 2) in 15.6 p.c. of the examined aged over 35 (according to the WHO criteria of 1985). The health care system reform in Poland has made more difficult the access of the diabetic to a specialist that treats this disease. Therefore doctors and nurses of primary health care have become more responsible for diabcare than before. The authors believe that the systematic education of primary health care doctors by specialists so that they can treat patients according to the modern standards of practical diabetology as well as sharing of tasks and responsibilities between primary and specialist diabetologic care, are very important. Primary health care would be in charge of prevention and early diagnosis of DM 2 as well as prevention and early diagnosis of concomitant complications of the disease. Specialists would have consultation on the patients at the moment of diagnosis and then at least once a year. They would also take care of search for and diagnosis of remote diabetes complications. Primary health care doctors would still treat most of diabetics with DM 2; specialist centres doctors would treat most of diabetics with DM type 1, patients with complications and from special risk groups (e.g. women with gestational diabetes).


    2440/2523

    Tytuł oryginału: Shaping of psycho-social independence in neurological patients.
    Tytuł polski: Kształtowanie psychospołecznej niezależności pacjentów neurologicznych.
    Autorzy: Adamczyk Kazimiera, Lorencowicz Regina, Rejszel Elżbieta, Zajko Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.556-563, bibliogr. 15 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było określenie poziomu niezależności psychospołecznej przed wprowadzeniem programu edukacyjnego i po nim. Przebadano 120 chorych, w tym 51 mężczyzn i 69 kobiet w wieku od 21 do 72 lat, stanu wolnego - 34 i małżeńskiego 86 osób, 33 badanych z wykształceniem podstawowym, 79 - średnim i 8 - z wyższym. Po udarze mózgowym było 67 pacjentów, ze stwardznieniem rozsianym - 31, z chorobą Parkinsona - 7 i z zespołem korzeniowym - 15 chorych. W pierwszym badaniu niezależność psychospołecza utrzymywała się głównie na poziomie średnim w zakresie wiadomości na temat stylu życia, z wyjątkiem używek, gdzie wykazano się dużą wiedzą jeszcze przed edukacją. Odnośnie do umiejętności oraz pozostałych aspektów psychospołecznych (motywacja, samoakceptacja, funkcjonowanie społeczne, sprawność intelektualna) badani reprezentowali przeważnie poziom bardzo wysoki i wysoki w badaniu drugim. Znacząca populacja niestety nadal wykazywała poziom średni, a także niski. Populacja reprezentująca bardzo wysoki i wysoki poziom niezależności psychospołecznej wzrosła o 25,0 proc.

    Streszczenie angielskie: The aim of the study was to determine the degree of psycho-social independence among neurological patients. The study was conducted by means of the Neurological Patients' Psycho-Social Independence Scale developed by the author, and covered 120 patients - 51 males and 69 females aged 21-72; unmarried - 34 and married - 86, with the level of education: elementary - 33, secondary school - 79 and university - 8; who had cerebral stroke - 67, multiple sclerosis - 31, radicular syndrome - 22. During the first stage of the study psycho-social independence remained primarily on the medium level with respect to the knowledge concerning life style, apart from the consumption of alcohol, strong tea and coffee, the patients showing a good knowledge of this problem prior to the implementation of the education programme. With respect to skills and the remaining psycho-social aspects (motivation, self-acceptance, social functioning, intellectual efficiency) the respondents represented primarily a very high or high level during the second study. Unfortunately, a considerable number of patietns still showed a medium or low level. Population who respresented a very high and high levels of psycho-social idnependence, increased by 25.0 p.c.


    2441/2523

    Tytuł oryginału: Psycho-social problems of HIV carriers.
    Tytuł polski: Problemy psychospołeczne osób zakażonych HIV.
    Autorzy: Borzęcki Andrzej, Sałaga-Pylak Monika, Święs Zofia, Jaskułowska Liliana, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.564-568, il., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • aIDS

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Nosicielstwo HIV i AIDS generuje wiele problemów nie tylko natury medycznej, ale także psychologicznej, społecznej i prawnej. Celem pracy była ocena wybranych problemów psychospołecznych wśród nosicieli HIV. Metodą badawczą był kwestionariusz. Badaniami objęto grupę 60 osób - nosicieli HIV. Uzyskane wyniki potwierdziły mnogość problemów, z którymi borykają się nie tylko nosiciele, ale także ich rodziny, a także konieczność edukacji społecznej w tej dziedzinie.

    Streszczenie angielskie: HIV carrier state and AIDS generate multiple medical, psychological, social and legal problems. The aim of the work was to evaluate selected psycho-social problems among HIV carriers. The examination method was a questionnaire. We interviewed 60 HIV carriers. The results obtained confirmed the existence of the problems affecting the carriers and their families. It creates need for social education in this field.


    2442/2523

    Tytuł oryginału: Interaction between local anesthetics and centrally acting antihypertensive drugs.
    Tytuł polski: Interakcje między środkami miejscowo znieczulającymi i centralnie działającymi lekami hipotensyjnymi.
    Autorzy: Żółkowska Dorota, Pikuła Anna, Borzęcki Andrzej, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.569-573, tab., bibliogr. 10 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie polskie: Leki znieczulające miejscowo są szeroko stosowane jako środki znoszące uczucie bólu przy małych zabiegach chirurgicznych i stomatologicznych. Ponadto znajdują zastosowanie jako leki antyarytmiczne. Ich mechanizm działania polega między innymi na zapobieganiu powstawania i przewodzenia impulsów we włóknach nerwowych poprzez blokowanie napięciozależnych kanałów sodowych w błonie komórkowej. Istotne znaczenie w wywoływaniu działań niepożądanych przez leki znieczulające miejscowo ma ich oddziaływanie na czynność ośrodkowego i obwodowego układu nerwowego oraz mięsień sercowy. Celem naszej pracy była ocena interakcji lidokainy, mepiwakainy oraz artykainy z ośrodkowo działającymi lekami hipotensyjnymi klinidyną i rezerpiną w modelu drgawek pentylenotetrazolowych. Lidokaina (50 mg/kg) oraz mepiwakaina (50 mg/kg) w sposób istotny statystycznie obniżały CD50 pentylenetetrazolu z 80,7 mg/kg na odpowiednio 56,7 mg/kg i 67,9 mg/kg, nie powodując podobnego efektu w dawce 25 mg/kg. Artykaina (50 mg/gk) nie zmieniała CD50 pentylenetetrazolu. Nie zaobserwowano obniżenia CD50 pentylenetetrazolu przy jednoczesnym stosowaniu leków znieczulających miejscowo z klinidyną i rezerpiną. Artykaina (50 mg/kg) stosowana łącznie z klinidyną (0,15 mg/kg) istotnie statystycznie nie podwyższała CD50 pentylenetetrazolu. Podsumowując: łączne stosownaie leków znieczulających miejscowo z ośrodkowo działającymi lekami hipotensyjnymi, jak klonidyna i rezerpina, nie powoduje nasilenia drgawek pentylenetetrazolowych. Artykaina wydaje się najbardziej bezpiecznym środkiem znieczulającym miejscowo, stosowanym u pacjentów z padaczką.

    Streszczenie angielskie: Local anesthetics are widely used in alleviating pain concomitant with small surgery procedures and in dentistry. Especially medication in ductal anesthesia after penetrating into systemic circulation can have significant influence on the central nervous system and stimulus conduction in the heart. Clonidine and reserpine are centrally acting antihypertensive drugs. The aim of this study was to examine an interaction of lidocaine, articaine and mepivacaine with some antihypertensive drugs clonidine and reserpine on the pentylenetetrazole induced seizures. In conclusion: articaine is the most safe local anesthetic and can be used in epileptic patietns Co-administration of local anesthetics with centrally acting antihypertensive drugs did not influence seizures activity in mice.


    2443/2523

    Tytuł oryginału: Influence of iodine ions in drinking water on their excretion with urine.
    Tytuł polski: Wielkość wydalania jodu z moczem a jego stężenie w wodzie pitnej.
    Autorzy: Borzęcki Andrzej, Borzęcka Halina, Zajączkowska Małgorzata, Smarkala Beata, Sieklucka-Dziuba Maria
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.574-578, il., tab., bibliogr. 16 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy była ocena zależności pomiędzy wielkością wydalania jodu w moczu a stężeniem jodu w wodzie pitnej u mieszkańców województwa lubelskiego. Badaniami objęto 71 osób. Wśród badanych było 19 dzieci w wieku od 7 do 18 lat i 52 osoby dorosłe w wieku od 19 do 80 lat, zamieszkałe w okolicach Zamościa. Stężenia jodu oznaczano w porannej porcji moczu i przeliczano na jednostkowe stężenie kreatyniny. Wodę do badań pobierano ze studni gospodarstw indywidualnych. Stężenie jodu w moczu i w wodzie pitnej oznaczano metodą Sandell-Kolthoffa. Poziom kreatyniny w moczu oznaczano metodą Folina. Zależność pomiędzy wydalaniem jodu w moczu a jego stężeniem w wodzie pitnej badano wyznaczając współczynnik korelacji liniowej Pearsona. Średnie stężenie jodu w moczu badanych osób wynosiło 132,0 ćg/g kreatyniny. Stężenie jodu w wodzie pitnej wynosiło średnio 27,5 ćg/l. Uzyskane wartości stężeń jodu zarówno w moczu, jak i w badanej wodzie pitnej nie odbiegały od wartości uznanych na podstawie piśmiennictwa za normę. Stwierdzono istotną statystycznie korelację między wielkością wydalania jodu w moczu a jego stężeniem w wodzie pitnej.

    Streszczenie angielskie: The purpose of the work was to appraise the correlation between magnitude of iodine excretion with urine and concentration of iodine ions in drinking water in the population living in the Lublin province. The tests were also performed among the citizens of the Zamość voivodship. Mean concentration of iodine in urine of the tested citizens was 132.0 ćg/g creatinine. Mean value of I ions in drinking water was 27.5 ćg/l. The obtained results of concentration of iodine both in urine and drinking water did not differ as shown in references. Statistically significant correlation between the measure of I excretion in urine and I ions concentration in drinking water was confirmed. There is no ascertained deficiency of iodine in Zamość region inhabitants. The concentration of iodine in drinking water from adjacent wells was fluctuating in wide limits, but did not differ from recommended norms. There is a positive correlation between concentration of iodine in drinking water and its level in excreted urine.


    2444/2523

    Tytuł oryginału: The demand for health education among patients with diabetes.
    Tytuł polski: Zapotrzebowanie na edukację zdrowotną wśród pacjentów z cukrzycą.
    Autorzy: Latalski Maciej, Skórzyńska Hanna, Pacian Anna
    Źródło: Ann. UMCS, Sect. D 2002: 57 (1) s.579-588, il., bibliogr. 5 poz., streszcz.
    Sygnatura GBL: 310,688

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Edukacja chorego na cukrzycę jest od wielu lat stałym elementem leczenia. Nadal jednak system szkoleń w zakresie tej choroby jest niedoskonały, a wiedza chorych na ten temat niewystarczająca. Celem pracy było określenie stopnia zapotrzebowania na edukację zdrowotną wśród pacjentów z cukrzycą poprzez ocenę poziomu ich wiedzy. Badaniami objęto 130 chorych na cukrzycę w wieku od 18 do 96 lat z czasem trwania choroby od roku do ponad 20 lat. Stan wiedzy pacjentów na temat tego schorzenia oceniono przy pomocy specjalnie przygotowanego kwestionariusza ankiety. Zastosowana ankieta obejmowała 54 pytania z których część dotyczyła ogólnych informacji o chorych na cukrzycę. Dalsza część ankiety badała wiedzę w zakresie istoty tej choroby, powikłań, samokontroli, stylu życia oraz zawierała pytania dotyczące źródeł zdobytej wiedzy na jej temat, udziału w spotkaniach edukacyjnych i szkoleniach dotyczących postępowania w cukrzycy oraz samooceny poziomu wiedzy. Z badań wynika, że 54,6 proc. chorych nie potrafi wyjaśnić, na czym polega cukrzyca typu 1. Również 39,2 proc. pacjentów nie zna istoty cukrzycy typu 2. Nikt z chorych nie potrafił bezbłędnie wskazać wszystkich objawów występujących w stanie hiperglikemii lub hipoglikemii, jak również narządów i układów, w których najczęściej występują późne powikłania. Ponad 1/3 badanych nie zna zasad prawidłowego żywienia w cukrzycy. Żaden z chorych nie potrafił poprawnie wskazać wszystkich badań kontrolnych, które powinny być wykonywane u ...

    Streszczenie angielskie: Education of the sick with diabetes has been a stable element of treatment for plenty of years. However, the system of trainings related to this disease is still not perfect and the knowledge of patietns about this subject is insufficient. The objective of the study was to determine the demand for health education among patients with diabetes by means of evaluating the level of their knowledge. The study included 130 people suffering from diabetes at the age from 18 to 96 with the disease duration ranging from one year to above 20 years. The levle of patients' knwoledge about this disease was examined with the use of the survey questionnaire, especially designed for these reasons. The applied survey consisted of 54 quesitons of which a substantial part was concerned with general information about people suffering from diabetes. Further sections of the survey explored the knowledge about the nature of the disease, its complications, self-control, lifestyle and contained the questions concerning the sources of the acquired knowledge on this subject, participation in educational meetings and trainings concerning the issue of coping with diabetes as well as self-evaluation of the level of knowledge. The survey shows that 54.6 p.c. of the respondents cannot explain the mechanisms of type 1 diabetes, while 39.2 p.c. of the patietns do not know the nature of type 2 diabetes. None of the patients was able to enumerate all the symptoms of hypoglycemia and hyperglycemia or the ...


    2445/2523

    Tytuł oryginału: Case Reports and Clinical Practice Review
    Tytuł angielski: Microsurgical resection of an epidemiology cyst of the cerebellopontine angle - a review of three cases.
    Autorzy: Stempniewicz Mirosław, Słoniewski Paweł, Iżycka-Świeszewska Ewa, Rzepko Robert, Szurowska Edyta
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.264-267, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Epidermoid cysts of the cerebellopontine angle, region, although benign in character, may pose a serious problem for neurosurgeons because of their spread, tendency to closly adhere to and involve such structures as the brain stem, cranial nerves and blood vessels. Case reports: The paper presents three cases of patients who underwent surgical treatment in the Department of Neurosurgery, Medical Uniwersity of Gdańsk in 1998-2000. The patients presented with non-specific symptoms such as headaches, tinnitus and trigeminal neuralgia. Clinical symptomatology together with CT and MRI results allowed to establish a correct preoperative diagnosis in one patient only. All the three cases of epidermoid cysts were treated surgically, but the decisions concerning the extent and methods of resection were taken individually. Conclusions: Aggressive surgical treatment in an attempt to remove the tumor radically may lead to neurological deficits such as those observed in the presented cases - slight nerve VII paresis. More conservative methods of resection, sparing a part of the tumor capsule closly adhering to the vascular structures, nerves or brain stem surface should always be considered. It is important to rinse throughly the surgical site with hydrocortisone in Ringer solution in order to remove residual cyst contents.


    2446/2523

    Tytuł oryginału: Case Reports and Clinical Practice Review
    Tytuł angielski: Diagnostic problems with recurrent intracerebral bleeding in a 10-year-old boy.
    Autorzy: Bełdziński Piotr, Lemka Małgorzata, Pilarska Ewa, Mazurkiewicz-Bełdzińska Maria, Dilling-Ostrowska Ewa, Słoniewski Paweł
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.268-272, il., bibliogr. 8 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Intracranial arteriovenous malformations (AVMs) are congenital lesions, which occur with aproximate frequency reaching 1,5 p.c. to 3 p.c. of the population. In children, hemorrhage is the initial presenting syndrome in 25 p.c. cases. In the majority of cases it is a severe intracerebral or intraventricular bleeding without other symptoms. The causes higher mortality rate in this group as compared with adult patients (25 p.c. vs. 6-10 p.c.). The diagnosis is based on computed tomography (CT), magnetic resonance imaging (MRI) and cerebral angiography (AG). Surgical extirpation of the lesions, embolization or radiosurgery, alone or in combinations, are the methods of choice in therapy. Case report: A 10-years-old boy who suffered from intracerebral bleedings from the arteriovenous malformation located in the occipital lobe is presented. Cerebral angiography performed after the second bleeding, revealed an aneurysm of the posterior right chorioideal artery as the cause of bleedings. The operation was performed with the use of a neuronavigation tool. Conclusions: The neuronavigation tool gave us the direct view into the location of pathology and enabled us to verify in situ the pre-operative diagnosis - none aneurysm were found The AVM could be totally resected using minimally invasive technique.


    2447/2523

    Tytuł oryginału: Case Reports and Clinical Practice Review
    Tytuł angielski: Anemia as a complication of parvovirus B 19 infection in a 2-year-old child.
    Autorzy: Krauze Agnieszka, Matysiak Michał, Krenke Katarzyna
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.273-275, bibliogr. 6 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • hematologia
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • płeć męska

    Streszczenie angielskie: Infection with human parvovirus B19 (PVB 19) is a relatively rare disease with various clinical manifestations, the most commom of which is infectious erythema . PVB 19 is also an etiologic factor of arthritis, chronic anemia and hydrops fetalis in ca. 5 p.c. of infected pregnancies. It is also responsible for aplastic crises in patients with congenital hemolytic anemias and those treated with immunosuppressants. Hematological complications after parvovirus B19 infections are rare in subjects, and especially in children, with no history of the aforementioned disorders. Therefore, we present such a case below.


    2448/2523

    Tytuł oryginału: Case Reports and Clinical Practice Review
    Tytuł angielski: Essential thrombocythemia - etiology and clinical course.
    Autorzy: Pałgan Krzysztof, Dziedziczko Andrzej, Kremplewska-Należyta Elżbieta, Pałgan Izabela
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.276-280, tab., bibliogr. 36 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Essential thrombocythemia (ET) belongs to myeloproliferative syndromes. It has a multifactor etiology. Dark hair dyes, benzene, electromagnetic radiation, infections with RNA viruses and genetic predispositions have been found to contribute to transformation of thrombocyte precursor cells. The most common complications of clonal thrombocytic proliferation are thrombosis, embolism and hemorrhages. The drugs most frequently used in treatment of the condition include hydroxyurea, anagrelide, interferon-alpha, melphalan, radioactive phosphorus, busulfan, chlorambucil, aspirin and dipyridamol.


    2449/2523

    Tytuł oryginału: Ehlers-Danlos syndrome - report of two cases.
    Autorzy: Woszczyk Dariusz, Widuchowska Małgorzata, Najda Jacek, Kucharz Eugeniusz J.
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.281-285, il., tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,612

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Ehlers-Danlos syndrome comprises a group of hereditary disorders of connective tissue characterized by joints hypermobility, skin abnormalities, dysfunctions of cardiac valves, varicose veins and osteoarthritis. The most common is the severe form of the disease with joint hypermobility and characteristically velvety, hyperextensible skin. Other type presents with a striking thinness of the skin and a predisposition to sudden death from rupture of large blood vessels or the large bowel. The underlying cause of connective tissue impairment leading to this syndrome is a group of mutations affecting the genes responible for collagen polypeptide chains coding and subsequent synthesis. The diagnosis of the disease is established mostly on the basis of clinical symptomatology. The current classification comprises 11 types of the disease. Case report: Two cases, representing types III and IV of the disease are presented and thoroughly analized, emphasizing clinical, diagnostic difficulties associated with them. In the case of the first of our patients, the diagnosis of type IV Ehlers-Danlos syndrome was based on the observation of translucent skin, cigarette paper-like scars with absence of significant joints hypermobility. The example of life-threatening vascular complications in this type is death of the patient's father because of abdominal aorta rupture. In the second case, the diagnosis of type III of the disease was established on the basis of evident joints hypermobility and their luxations, postoperative 'cigarette paper'-like scars and hernias, with rapidly appearing signs of cripplehood...


    2450/2523

    Tytuł oryginału: A hydatid cyst of the left adrenal gland.
    Autorzy: Remiszewski Piotr, Pawlak Jacek, Grodzicki Mariusz
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.286-289, il., bibliogr. 7 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Hydatid cysts of abdominal organs are a rare type of tumors and their detection is usually accidental. Case report: The reported case of a 50-year-old female patient presents the diagnostics and treatment of a tumor located in the retroperitoneal space in the left suprarenal region. The lesion was diagnosed as a hydatid cysts of the left adrenal gland. Conclusions: Location of aprimary hydatid cysts in the adrenal gland is extremely rare, but provides an example illustrating that also tumors of parasitic origin must be taken into consideration in differential diagnostics of abdominal tumors.


    2451/2523

    Tytuł oryginału: Osteopoikilosis and Buschke-Ollendorff syndrome.
    Autorzy: Kotulska Anna, Kucharz Eugeniusz J.
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.290-293, bibliogr. 55 poz.
    Sygnatura GBL: 313,612

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The disorder (known as spotted bones, diffuse osteopathy, osteopoikilosis) is a congenital disease of the skeletal system characterized by numerous, round foci of bone sclerosis localized within spongy bone tissue. Coincident osteopoikilosis and cutaneous lesions (fibromas) is referred to as Buschke-Ollendorff syndrome. The disease is inherited as an autosomal dominant trait. Osteopoikilosis is usually asymptomatic and is diagnosed accidentally in radiography performed for other reasons. Osteopoikilosis may be accompanied by melorheostosis and/or osteopathia striata. This syndrome is known as mixed sclerosing bone dystrophy.


    2452/2523

    Tytuł oryginału: Myopia - epidemiology, pathogenesis, present and coming possibilities of treatment.
    Autorzy: Czepita Damian
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.294-300, il., tab., bibliogr. 66 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The contemporary views on the epidemiology, pathogenesis as well as treatment of school and progressive myopia are discussed. The history of myopia investigations is described. The results of papers indicating the environmental and genetic reasons of myopia are presented. Special attention is focused on the anatomical, physiological and biochemical transformations in the course of progressive myopia. The attitude towards some conservative and surgical methods of school and progressive myopia is expressed. The anatomical and biochemical changes taking place in the eye with experimental myopia are characterized. The substances inhibiting the progress of experimental myopia are described. The possibilities of using the newst experimental results in progressive myopia treatment are indicated.


    2453/2523

    Tytuł oryginału: Soy isoflavones in prevention of civilization-related diseases.
    Autorzy: Mikołuć Bożena, Motkowski Radosław, Białokoz-Kalinowska Irena, Piotrowska-Jastrzębska Janina
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.301-305, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,612

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Soy is one of a few plants in which complementary protein is present, containing 8 essential amino acids (tryptophan, phenylalanine, lysine, threonine, methionine, leucine, isoleucine, valine), which cannot be produced by the organism, but are indispensable for its proper functioning. Soy contains no cholesterol. It is a rich source of nutriceuticals, isoflavones, protease inhibitors, phytic acid, cellulose, which are capable of inactivation of carcinogens, stimulation of the immune system, and possess a number of properties which may be used in prevention of cardiovascular diseases and other civilization-related pathologies (atherosclerosis, neoplasms). The paper presents metabolism of isoflavones in the human organism, as well as the hypothese concerning molecular mechanisms of the effect of genistein, which is the most abundant isoflavoner occurring in soy. The most important effects of soy and its components on human organisms arealso discussed.


    2454/2523

    Tytuł oryginału: Screening and prevention of cervical cancer. Future directions and new stakes.
    Tytuł polski: Profilaktyka raka szyjki macicy - stan obecny oraz założenia na przyszłość.
    Autorzy: Monsonego Joseph
    Źródło: Kolposkopia 2002: 2 (1) s.1-6, bibliogr. 44 poz., streszcz.
    Sygnatura GBL: 313,653

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: Rak szyjki macicy jest jednym z najczęściej obserwowanych schorzeń narządu rodnego w populacji kobiet na świecie. Ryzyko wystąpienia choroby w krajach wysokorozwiniętych, w których wdrożono programy profilaktyczne zostało zredukowane praktycznie do 1 proc. Fakt ten jest jednym z najlepszych wykładników koniecznych prowadzenia działań prewencyjnych, opierających się na stałym, populacyjnym monitoringu przy pomocy uznanych skriningowych testów diagnostycznych. Niniejszy artkuł jest zbiorem ustaleń, które zostały opracowane podczas 4-tej Międzynarodowej Konferencji "The Eurogin 2000" w Paryżu. Przedstawia wstępną analizę epidemiologiczną, ze szczególnym wyróżnieniem roli infekcji wirusem brodawczaka ludzkiego (HPV - Human Papilloma virus) w patogenezie stanów przednowotworowych i nowotworowych szyjki macicy. Określa korzyści wynikające z wdrożenia populacyjnych programów skriningowych. Zawiera także przegląd nowoczesnych technik diagnostyczno-terapeutycznych (zautomatyzowane badanie cytologiczne, kolposkopowe testy HPV-DNA) będących obecnie podstawowymi narzędziami w profilaktyce wyżej wymienionego schorzenia oraz ustala ich miejsce w algorytmie postępowania medycznego. Obligatoryjność stosowania ich wydaje się naturalną konsekwencją w przyszłej optymalizacji metod skryningowych. Osiągnięcie wysokiej skuteczności w profilaktyce raka macicy związane jest z realizacją kompleksowych algorytmów postępowania z tym schorzeniem, ze szczególnym uwzględnieniem stanów przednowotworowych. Tylko taka forma działań prewencyjnych stwarza przesłanki do eliminaccji tego zjawiska z populacji.

    Streszczenie angielskie: The Eurogin 2000 4th International Multidisciplinary Conference was held at the Paris Convention Center from April 5 to 9, 2000. It provided an update on the most recent status of technological and therapeutic research and development in the area of cervical precancers and cancers and papilloma virus infections.


    2455/2523

    Tytuł oryginału: Application of HPV-testing in daily practice.
    Tytuł polski: Zastosowanie testów HPV w codziennej praktyce.
    Autorzy: Agorastos Theodoros, Dinas Konstantinos
    Źródło: Kolposkopia 2002: 2 (1) s.7-10, tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 313,653

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie polskie: Według najnowszej wiedzy zakażenie nabłonka szyjki macicy Wirusem Ludzkiego Brodawczaka (Human Papilloma Virus - HPV) jest warunkiem wstępnym wystąpienia procesu karcinogenezy w obrębie szyjki macicy. Biorąc ten fakt pod uwagę dyskutuje się aktualnie możliwość stosowania tsetów HPV tj. wykrywania DNA onkogennych podtypów HPV w codziennej praktyce w celu zapobiegania rozwoju inwazyjnego raka macicy. Badania rozpatruje się w trzech grupach kobiet: a. pacjentki bezobjawowe (jako pierwotny test przesiewowy) b. kobiety z występującymi niejednoznacznymi zmianami atypowymi lub z dysplazją małego stopnia (grupa wyselekcjonowania), c. Kobiety po leczeniu przedinwazyjnych zmian szyjki macicy (jako badanie kontrolne). Jak dotąd istniejące dane preferują zastosowanie testów HPV w każdej z owych trzech grup oferując lepsze wartości predykcyjne w porównaniu do badań cytologicznych, mniejsze koszty i większą wygodę dla kobiet.

    Streszczenie angielskie: Considering the new knowledge, that a preceded infection of cervical epithelium by Human Papilloma Virus (HPV) is prerequisite for cervical carcinogenesis, the application of the so-called HPV-test, i.e. the DNA-detection of one or more oncogenic HPV-subtypes, in daily practice are nowadays under discussion regarding three population groups of women, aiming to the prevention of invasive cervical cancer: a. asymptomatic women (as a primary screening test), b. women with equivocal, atypical or low grade dysplastic cytological findings (as a triage method), and c. women after treatment of preinvasive or early invasive cervical neoplasias (as a folloe-up method). So far, the existing results favor the use of HPV-testing in any of the three fields of interest, resulting in better predictive values, in relation to Papanicolaou-test, lower cost, and more convenience for the women.


    2456/2523

    Tytuł oryginału: Age-dependent effect of limb immobilization and remobilization on rat bone.
    Autorzy: Trębacz Hanna, Dmowska Mirosława, Baj Jacek
    Źródło: Folia Biol. 2002: 50 (3/4) s.121-127, il., tab., bibliogr. [23] poz.
    Sygnatura GBL: 302,991

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The effect of unilateral hindlimb immobilization and subsequent free remobilization on bone tissue in rats was examined. Right hindlimb of intensively gowing (G), young adult (Y) and adult (A) male rats was immobilized by taping for two weeks. Bone tissue was investigated post mortem in experimental and age-matched control rats, either directly after immobilization (Imm) or after two or four weeks of remobilization (Re2, Re4). Apparent density (dapp) and mineralization (Min) were estimated in femora and pelvis. The mechanical state of bone tissue in femora was evaluated using an ultrasonic method. Additionally, activity of serum alkaline phosphatase, and serum calcium and phosphorus were measured in each group. Min and dapp in Imm bones were changed in G rats, while in Y and A only dapp in Imm femora was affected. Velocity of ultrasound was significantly lower in immobilized femora in each age group, indicating decreased elasticity of bone tissue. The differences between immobilized and control limbs were still significant in Re2 and Re4 groups in G rats. In Y rats the differences between experimental and control bones increased during remobilization. It is concluded that deterioration of bone initiated during two weeks of unloading, last within at least four weeks of free remobilization, despite restoration of normal activity.


    2457/2523

    Tytuł oryginału: Astereological analysis of FRTL-5 cells as an effect of thyrotropin and irradiation.
    Autorzy: Stiblar-Martincic Draga, C”r Andrej, Pajer Zdenka
    Źródło: Folia Biol. 2002: 50 (3/4) s.173-177, il., bibliogr. [25] poz.
    Sygnatura GBL: 302,991

    Hasła klasyfikacyjne GBL:
  • onkologia
  • endokrynologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: FRTL-5 cell line is a cloned epithelial follicular cell line from Fischer rat thyroids. This cell line expresses many of the thyroid differentiated markers in vitro. Their growth and function depend on thyrotropin (TSH) as the main regulatory hormone. In this astereological analysis, the authors concentrate on FRTL-5 nuclei as the most vulnerable part of the cell. Using morphometrical variables, they wished to discver the morphologically identifiable sing of transformation of FRTL-5 cells after irradiation and to study the effect of different TSH concentrations. FRTL-5 cells were grown in a medium of 4 different concentrations of TSH (0, 0.1, 1, 10 mU/ml) and irradiated with 0 Gy, 2 Gy, and 4 Gy. The results showed that the nuclear-cytoplasmic ratio decreases after irradiation with doses of 4 Gy or if TSH was included in the medium. The nuclear maximum diameter of FRTL-5 cells increased with higher concentrations of TSH more obviously after irradiation with 4 Gy than with 2 Gy. On the basis of astereological analysis, it was concluded that different concentrations of TSH and irradiation exert an effect especially upon FRTL-5 cell nuclei. The possible transformation of FRTL-5 cells after culturing in TSH medium and after irradiation could be confirmed by injection into an animal of the Fischer strain.


    2458/2523

    Tytuł oryginału: Stress and immunity: minireview.
    Autorzy: Płytycz Barbara, Seljelid Rolf
    Źródło: Folia Biol. 2002: 50 (3/4) s.181-189, tab., bibliogr. s. 187-189
    Sygnatura GBL: 302,991

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • immunologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Stress, a state of threatened homeostasis, may be induced by various physical or psychological factors (stressors), including antigenic stimulation. Stressful experiences may affect both physical/psychological well being and immune functioning of humans and animals; the ongoing immune reaction may affect other physiological functions and psychological comfort. The molecular basis of these effects involves a network of multidirectional signalling and feedback regulations of neuroendocrine- and immunocyte-derived mediators. The consecutive stages of the multistep immune reactions might be either inhibited or enhanced owing to the previous and/or parallel stress experiences, depending on the kind of stressor and the animal species, strain, gender, or age. Therefore, the final results of stress-induced alteration of immune reactions are difficult to predict. The effect of a particular stressor on immune functions varies according to the previous stress experience of the individual (e.g. social confrontation, sterile saline injection) while various stressors may act in the same or in opposite ways on the same immune parameter. In general, the efficacy of immune response depends on the neuroendocrine environment on which it is superimposed. Conversely, neural and endocrine responses depend on the concurrent immune events upon which they are superimposed. It seems that the consequences of stress on the immune functioning are generally adaptive in the short run but can be damaging when stress is chronic.


    2459/2523

    Tytuł oryginału: The long-term effect of cadminum exposure through food on the postnatal development of the bank vole (Clethrionomys glareolus Schreber, 1780).
    Autorzy: Białońska Dobrosława, Zakrzewska Marta, Sawicka-Kapusta Katarzyna, Konior Magdalena
    Źródło: Folia Biol. 2002: 50 (3/4) s.203-209, tab., bibliogr. [36] poz.
    Sygnatura GBL: 302,991

    Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Cadmium is well known for its toxicity to the animal body. However, its effect on pregnancy and development of young animals is still not well understood. This study examined such effects, using bank voles captured from the wild to make the results closer to those which could be expected in the natural environment. One group of animals was fed 7ćgg-1 cadmium in the food, a second 35ćgg-1, and a third no cadmium, as a control. The concentrations of cadmium in the whole bodies of young bank voles were determined on the 3rd, 5th, or 10th day of life. The cadmium level in the bodies of animals exposed to 35ćgg-1 of cadmium was significantly higher than in those from either the control group or the group receiving 7ćgg-1 of cadmium, which did not differ from each other. The cadmium level did not change with animal age in any of the study groups. Concentrations of Zn, Cu, and Fe were also determined in the whole body of young animals, as cadmium is known to disturb the metabolism of these essential metals throuhg antagonistic activity. Both Cu and Fe levels were negatively correlated with cadmium concentrations, while a positive correlation was found between zinc and cadmium in the young animal bodies. Also found was higher offspring mortality in the group receiving 35ćgg-1 of cadmium in food. There was no difference in young animal body weight between the study groups.


    2460/2523

    Tytuł oryginału: Postprandial glucose determinations: are one and two hours the same?
    Autorzy: Langer Oded, Carver Kristen, Langer Menachem
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.7-8, tab., bibliogr. 10 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: The aim of the study was to determine if different postprandial glucose testing protocols produce comparable glucose profiles. Two hundred forty five gestational diabetic women were enrolled in this prospective study. The 2-hour determination with fasting plasma glucose should be used as the testing scheme for GDM.


    2461/2523

    Tytuł oryginału: Longitudinal assessment of amniotic fluid index in diabetic pregnancies.
    Autorzy: Langer Oded, Arredondo-Soberon Francisco, Langer Menachem, Carver Kristen
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.9-11, tab., bibliogr. 20 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Objectives: (1) to assess the association between Amniotic Fluid Index (AFI) and level of glycemia in pregnant diabetic women: and, (2) to compare the characteristics of AFI in non-diabetic and diabetic pregnancies. Method and materials: 174 diabetic and 447 non-diabetic aubjects participated in the study. Amniotic Fluid Index was measured weekly throughout pregnancy. Blood glucose was monitored utilizing self monitoring blood glucose 7 determinations/daily. Resaults: (1) there was a significant difference between diabetic and non-diabetic individuals (p 0.0001); (2) when glucose was compared in diabetic patients in different gestational categories, no significant difference was found in the level of glycemic control; (3) comparable AFI volumes were found for gestational and pre-existing diabetic women; (4) no association was found among level of glycemia, AFI, fetal size, and polyhydramnios. Conclusion: Achieving the targeted level of glycemia in the pregnant diabetic will minimize the risk for polyhydramnios comparable to that of the general population.


    2462/2523

    Tytuł oryginału: Glipizide does not influence human placenta glucose metabolism in the absence of insulin - in vitro studies.
    Autorzy: Sikorski Marek, Sikorska Anna, Źrubek Henryk
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.12-15, il., bibliogr. 32 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płód
  • in vitro

    Streszczenie angielskie: Studies indicating second generation sulphonylurea derivatives (oral hypoglycemic agents) insignificant placental transfer allowed successful clinical trials of their application in gestational diabetes. Little is known so far on the direct (independent of insulin receptor density modification) action of sulphonylureas on placental glucose metabolism, though such an influence, if profound, may adversely alter fetoplacental homeostasis. To investigate the glipizide influence on glucose utilization lactates production by human term placental cotyledon in the environment deprived of insulin extracorporeal dual (maternal and fetal side) perfusions of isolated human placenta cotyledon lasting 120 min each had been performed on 5 placentas without glipizide (control group - K) and with glipizide of mean initial maternal concentration of 205.28 mg/l (therapeutical level - 5 perfusions - group G) or ten-fold higher (2008 mg/l - next 5 perfusions - group GG). Glucose utilization and lactates production have been calculated for 30 min intervals and compared between groups. Mean glucose utilization (mmol/g/h) in maternal circvulation was within 7.68 - 9.57; 7.71 - 9.09 and 7.67 - 9.08 range, whereas mean lactates production (mmol/g/h) was within 7.49 - 7.85; 6.99 - 9.17 and 7.12 - 8.43 range for group K, G and GG respectively. Neither glucose consumption nor lactates production differed significantly between groups (lowest p values 0.15 and 0.36, respectively). We conclude that glipizide does not influence human placenta glucose consumption and lactates generation in the environment deprived of insulin.


    2463/2523

    Tytuł oryginału: The value of Doppler assessment of uteroplacental perfusion in the II and III trimester of pregnancy.
    Autorzy: Sawicki Włodzimierz, Śpiewankiewicz Beata, Cendrowski Krzysztof, Bachanek Michał, Stelmachów Jerzy
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.16-21, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Objectives: To evaluate flow resistance in middle cerebral, umbilical, and placental arteries in the second and third trimesters of pregnancy, and set down the initial reference values in the succeeding weeks of the II and III trimesters of pregnancy. Methods: This was a prospective observation study in 326 normal pregnancy between 26 and 40 weeks of gestational age. Serial Doppler measurements were made of the middle cerebral artery, umbilical artery and placental artery and RI, S/D and UA/MCA rations in each vessel were calculate. Rresults: Flow resistance in middle cerebral artery remained about on the same level in consecutive weeks of pregnancy. The RI ranged from 0.72 to 0.82 (mean 0.75 ń 0.08), and S/D from 4.17 to 5.55 (mean 4.69 ń 1.99). They showed a little declined tendency (the r coefficient respectively - 0.53 and - 0.22), but not statistically significant. However, in umbilical artery and placental chorionic plate arteries a gradual decline of flow resistance was reported (the r coefficient for RI and S/D respectively = -0.78 and - 0.88 - p 0.05, and -0.71 and - 0.88 - p 0.05). The mean RI value respectively was 0.57 ń 0.1 and 0.44 ń 0.11, and the mean S/D ratio value = 2.56 ń 0.88 and 1.99 ń 0.51. Similary umbilical/cerebral ratio (UA/MCA) was found out decrease (the r coefficient = -0.74 - p 0.05), with the mean value amounting 0.75 ń 0.16. Conclusions: Resistance to flow in umbilical and placental chorionic artery in normal pregnancy is low and has weaken tendency, unlike in mildde cerebral artery where resistance remains more or less on the same high level in succeding weeks of pregnancy.


    2464/2523

    Tytuł oryginału: Non-surgical, management of cervical incompetence by vaginal pessary installation.
    Autorzy: Sikorski Marek
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.22-24, tab., bibliogr. 19 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Relatively high incidence of cervical incompetence as a cause of midtrimester pregnancy losses prompts the wide use of cervical cerclage procedures, with considerable complications rate and of non definitely proven value. In search for alternative for surgical approach the study was aimed to evaluate the singleton pregnancies outcome after incompetent cervix treatment with vaginal pessaries installation. Sonographically confirmed cervical incompetence has been diagnosed in 14 consecutive pregnant women and corrected by vaginal pessary application between 15-22 week of gestation. There were only two cases of delivery at 36 week (mean 38.6), no case of birth weight lower than 2500 g (mean 3169), 3 cases of preterm rupture of membranes (21 p.c.), 5 cases of additional tocolysis required, and one case requring surgical cerclage. Microbiological cultures have not revealed clinically significant alterations of the vaginal flora. 5 primary cesarean deliveries have been performed due to complications not related to incompetent cervix management. Effectiveness of pessary comparable to the cerclage, low costs, simple out-patients procedure, patients' comfort and extremely low complication rate suggest the value of cervical pessaries as an alternative to surgical procedure in selected cases of incompetenet cervix.


    2465/2523

    Tytuł oryginału: Comparison of cervical sonography and fetal fibronectin in diagnosing patients with preterm labor.
    Autorzy: Hincz Piotr, Wilczyński Jan, Kozarzewski Marek, Pawłowicz Paweł, Krekora Michał, Borowski Dariusz, Bielak Adam, Szaflik Krzysztof
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.25-27, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Objective: The purpose of our study was to compare predictive values of fFN and cervical sonography in patients with signs and symptoms pf preterm labor. Study design: We prospectively evaluated 82 patients admitted with preterm labor. In each case an assay of fetal fibronectin (fFN) in the cervico-vaginal secretions and transvaginal sonographic examination of the uterine cervix was performed. The outcome measure was delivery 28 days. Results: 17.1 p.c. (14/82) of the examined patients 28 days. Among the analyzed sonographic parameters of the cervix only the functional canal lenght (FCL) was significantly correlated with PTD 28 days (21.6 ń 7.0 mm vs 30.1 ń 6.5 mm, p 0.001). Positive fFN was found in 71.4 p.c. of patients delivered 28 days and in 7.4 p.c. delivered 28 days (p 0.001). Analysis of ROC curves revealed two important cutoff for FCL. FCL 20 mm predicted preterm delivery (PTD) 28 days with sensitivity 57.1 p.c., specificity 92.6 p.c. and PPV and NPV 61.5 p.c. and 91.3 p.c. respectively. For FCL 31 mm sensitivity was 100 p.c., specificity 47.1 , PPV 28 p.c. and NPV 100 p.c. The 10th percentile (26 mm) had lower diagnostic capability. Positive fFN testing had sensitivity 71.4 p.c., specificity 92.6 p.c., PPV 66.7 p.c. and NPV 94.0 p.c. The sensitivity, specificity, PPV and NPV for fFN were somewhat better than any other single parameter. However, the areas under cirve for fetal fibronectin and functional canal lenght were 0.806 and 0.816 respectively and the difference (0.011) was not statistically significant,...


    2466/2523

    Tytuł oryginału: Maternal serum pro-inflammatory cytokines in pregnancy, labor and chorioamnionitis.
    Autorzy: Nowak Marek, Oszukowski Przemysław, Jaczewski Bogumił, Wierzbicka Elżbieta, Wilczyński Jacek R., Szpakowski Artur, Czichos Ewa, Małafiej Eugeniusz, Szpakowski Marian
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.28-30, tab., bibliogr. 15 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • ciąża
  • płeć żeńska

    Streszczenie angielskie: The purpose of our study was to compare maternal serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in gravidities, during spontaneous term and preterm labor and their relation to histologic chorioamnionitis. We investigated 106 women: 33 in preterm labor, 53 in term labor and 20 healthy pregnant non laboring controls. Venous bloods for cytokines determinations were obtained during the first stage of labor and during routine screening tests. Titers of cytokines were measured by means of ELISA technique. All afterbirths after preterm deliveries were examined to establish histologic chorioamnionitis. Serum levels of IL-6, IL-8 and THF-alpha were significantly elevated both in term and preterm labor when compared to non laboring gravidities. IL-6, IL-8 and TNF-alpha titers were statistically similar in term and proterm labors and in patients with and without histologic chorioamnionitis. Serum levels of investigated inflammatory cytokines in cases of term and preterm labor are elevated in comparison to non laboring gravidities. The elevated levels of these cytokines are not connected with coexisting chorioamnionitis.


    2467/2523

    Tytuł oryginału: Diagnostic aspects of fetal/neonatal cystic adenomatoid lung malformation at the reference centre.
    Autorzy: Kasprzak Elżbieta, Respondek-Liberska Maria, Kaniewska Danuta, Biegański Tadeusz, Czichos Ewa, Gadzinowski Janusz
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.31-34, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki
  • płeć żeńska
  • ciąża

    Streszczenie angielskie: Congenital cystic adenomatoid malformation (CCAM) of lungs is a relatively rare developmental anomaly, at present could be diagnosed prenatally. This study presents our own experience in CCAM diagnosis during fetal and neonatal life, using ultrasonography, echocardiography, X-ray and computed tomography.


    2468/2523

    Tytuł oryginału: Amniotic fluid excretion of N-acetyl-á-D-glucosaminidase molecular forms during pregnancy complicated by oligohydramnios or premature rupture of the membranes.
    Autorzy: Milnerowicz Halina, Zalewski Jerzy, Madej Paweł
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.35-39, tab., bibliogr. 21 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • badanie porównawcze
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • płód
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć żeńska
  • ciąża
  • in vitro

    Streszczenie angielskie: Amniotic fluid N-acetyl-á-D-=glucosaminidase (NAG) activity exceeded several times the upper limit of normal range (105 J/mmol creatinine) although the urinary tract defects in fetuses and newborns of the study group of women with idiopathic oligohydramnios were not found. Significantly higher amniotic fluid NAG activity was found in pregnancies with group of women with idiopathic oligohydramnios then in those with premature rupture of the membranes (PROM). In this group, a positive correlation was observed between NAG-A isoform activity and Pb ions (NAG-A/Pb r = 0.834; p 0.01). In the amniotic fluid of patients with oligohydramnios, positive correlation between total NAG activity (NAG/Cd r = 0.802; p ó 0.05), NAG-A isoform with Cd ions (NAG A/Cd r = 0.776; p ó 0.01), and NAG-B isoform with Pb ions (NAG B/Pb r = 0.750; p = 0.05) was revealed. The results obtained seem to indicate a significant contribution of Cd and Pb in releasing NAG into amniotic fluid in patients with oligohydramnios.


    2469/2523

    Tytuł oryginału: Efficacy of broncho-pulmonary surfactant solution lavage in treatment of meconium aspiration syndrome in newborn.
    Autorzy: Gulczyńska Ewa, Sobolewska Barbara, Zjawiona Agnieszka, Krawczyk Maria, Lerch Elżbieta, Cyranowicz Bogusława, Gadzinowski Janusz
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.40-43, il., tab., bibliogr. 20 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Objective: The aim of the study was to compare therapeutic methods of Meconium Aspiration Syndrome treatment: exogenous surfactant supplementation versus broncho-pulmonary surfactat solution lavage. Material and methods: Between 1993 and 2001 15 neonates were treated at Research Institute of Polish Mother's Hospital due to Meconium Aspiration Syndrome. Studied population was divided in two groups according to treatment's method. Group I - consisted of 8 infants born in 1993 -1998. Neonates received natural surfactant supplementation. Mean GA was 39 weeks (range 38-40) and mean birth weight was 3497 g (range 2550-4100 g). Group II - included 8 infants born after 1998, who were treated with broncho-alveolar natural surfactant solution lavage (5 mg phospholipids/ml; 15 ml/BW). Mean gestational age was 39.4 weeks (range 38-40) and mean birth weight was 3287 g (range 1700-3800 g). In bothe groups we compared: alveolar-to-arterial oxygen gradient (A - aDO2) and oxygen index (OI) measured every 6 hours during first day of life and every 24 hours till 7 day of life. The total ventilation time, duration of oxygen supplementation and the time of hospitalization were also analyzed. Results: In the lavage group shorter ventilation time; 3.1 (0.5 - 7) vs 7.9 (4=-13) days as well as total oxygen supplementation period; 7.8 (0.5 - 14) vs 12.3 (5-23) and time of hospitalization; 16.1 (6-41) vs. 27 (18-40) were observed. However, alveolar-to-arterial oxygen gradient (A-aDO2) and oxygen index (OI) were initially comparable in both groups...


    2470/2523

    Tytuł oryginału: The activity of protein C in the blood of preterm infants with birth weight below 1500 g, with or without intracranial haemorrhages.
    Autorzy: Korbal Piotr
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.44-46, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Intracranial haemorrhages (IVH) are still a major problem in the neonatology. It is predominantly a disorder of preterm infants especially newborns with body mass less than 1500 g. This complication is frequently the cause of death during the first few days of life or leaves permanent damage to the central nervous system. The etiology of this hemorrhages is multifactorial. The role of abnormalities of hemostatic system especially coagulation in the development of IVH is incompletely understood. The purpose of our study was to examine activity of protein C(PC) in the groups of premature infants with or without IVH. We determined decreased PC activity in the group with IVH with birth weight 1500 g. In the groups of premature infants with birth weight less than 1500 g significant differences we observed depending on grade of IVH.


    2471/2523

    Tytuł oryginału: Antithrombin activity in the plasma of the premature infants with intraventricular haemorrhages.
    Autorzy: Korbal Piotr, Jurkowska Małgorzata, Szymański Wiesław
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.47-49, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Intracranial haemorrhages (IVH) are still a major problem in the neonatology. This complication is predominantly a disorder of preterm infants especially newborns with body mass less than 1500 g. The etiology of this hemorrhages is multifactorial. The role of abnormalities of hemostatic system especially coagulation in the development of IVH is incompletely understood. The purpose of our study was to examined activity of antithrombin (AT), previously (ATIII) in the groups of premature infants with or without IVH. We determined decreased AT activity in the group with IVH with birth weight 1500 g. In the groups of premature infants with birth weight less than 1500 g significant differences we observed depending on grade of IVH.


    2472/2523

    Tytuł oryginału: The use of neuroendoscopic procedures in neonates.
    Autorzy: Nowosławska Emilia, Polis Lech, Polis Mariola, Mikołajczyk Wanda, Krawczyk Jacek, Zakrzewski Krzysztof
    Źródło: Arch. Perinat. Med. 2002: 8 (4) s.50-55, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 306,526

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: From 1997 to 2002, 20 neonates were operated on with use of neuroendoscopic techniques at the Neurosurgical Department. The age of children at the moment of neuroendoscopic procedure ranged from one day to 30 days of life. Children were at the average age of 18 days after birth. That group was composed of 13 girls and 7 boys. In three cases neuroendoscopic procedures were performed because of archnoid cysts (cysts of Quadrigeminal Plate Cistern), in additional three cases because of "multiloculated" hydrocephalus. The rest of children were subjected to operations because of non communicating hydrocephalus. The common aim of all neuroendoscopic procedures was to restore hydrodynamic order. All neuroendoscopic procedures were done with use two types of rigid endoscopes - GAAB system (outer diameter of 5.4 mm) and Aesculap (outer diameter of 6.4 mm). Considering a success rate in dependence on type of CSF hydrodynamics disturbances, it was observed that the most succesful rate of neuroendoscopic procedures was reached in the arachnoid cysts group. The worst results in neuroendoscopic procedures were obtain in group of children affected to non communicating hydrocephalus. The decrease of fluid compartmens after neuroendoscopic procedures was subjected to evaluation in all kinds of CSF hydrodynamics disturbances. In group of children suffered from arachnoid cysts and from multiloculated hydrocephalus all patients had fluid compartment reduced by more than 50 p.c. of their capacity. In the contrast to those neonates, a ventricular system of children with non communicating...


    2473/2523

    Tytuł oryginału: The effect of heavy metal accumulation on metallothionein content in selected tissues of bank voles and yellow-necked mice caught near a steelworks and zinc smelter.
    Autorzy: Damek-Poprawa Monika
    Źródło: Folia Biol. 2002: 50 (3/4) s.211-214, tab., bibliogr. [18] poz.
    Sygnatura GBL: 302,991

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The effect if cadmium, zinc, and copper accumulation on metallothionein content in the selected tissues of bank voles and yellow-necked mice trapped near the Sendzimir Steelworks in Krakow and the zinc smelter in Bukowno were analysed. The Borecka Forest was chosen as a control area. The highest cadmium concentration, 32,98 ćg g-1 dry weight, was detected in the kidneys of the bank voles caught in the Bukowno area. Zinc and copper concentrations in the tissues did not exceed the critical values. Metallothionein content in the liver and kidneys was associated with heavy metal accumulation in the tissues. The highest content of sulphydryl groups was detected in the livers of the bank voles trapped within the neighbourhood of the zinc smelter in Bukowno. The highest level of disulphide bonds was found in the kidneys of the bank voles from the same area.


    2474/2523

    Tytuł oryginału: Peripheral pulmonary carcinoid.
    Autorzy: Erella Venkata S., Larson Barbara E., Rodriguez Heron E., Blecha Matthew J., Connolly Mark M., Podbielski Francis J.
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.209-211, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Primary neuroendocrine tumors of the lung are uncommon neoplasms. Of those found, the vast majority occur in the distal trachea and proximal larger airways. The risk of metastasis depends on the histologic subtype of the tumor. Case report: Our patient is a 46-year-old woman who developed a cough and presented with hemoptysis. Further evaluation revealed a two-centimetr lung mass in her left lower lobe. The mediastinum was radiographically negative. A lung resection was performed that revealed a well-differentiated typical carcinoid tumor. Given its size and nodal status the tumor was assigned a T1NoMx class or Stage 1 malignancy. Conclusions: The atipical location of this uncommon pulmonary neoplasm raises sailent issuies regarding the appropriate evaluation of indeterminant pulmonary nodules. The routine use percutaneous lung biopsy with its small sample size could lead to an error in diagnosis, as differentiation between small cell lung cancer and neuroedocrine tumors can often be difficult. We belive the optimal approach to treatment of a solitary pulmonary nodule in a patient with a radiographically negative mediastinum should be flexible bronchoscop, and if not contraindicated, open or VATS resection of the nodule for definitive diagnosis and treatment.


    2475/2523

    Tytuł oryginału: Vena azygos lobe: A cause of decompression illness?
    Autorzy: Anegg U., Maier A., Fell B., Sankin O., Tomaselli F., Stacher R., Ebner F., Smolle-Jttner F. M.
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.212-216, il., bibliogr. 9 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: The vena azygos lobe is an accessory lobe localized paramediastinally within the right upper lobe underneath a pleural fold running from the pleuar apex to the vena azygos. This entity can be seen in approximately 0.4-1 p.c. of the population and usually does not cause any symptoms at all. In rare cases inflammatory or poststenotic changes may evolve in this 'pseudolobe'. Diving accidents frequently occur due to pulmonary barotrauma caused by local overinflation of lung tissue as a consequence of inappropriate decompression. A diver, however, is prone to experience pulmonary barotrauma, especially if morphologic pulmonary changes have compromised expiratory air ventilation. Case report: A 58-year-old male recreational diver experienced cerebrospinal DCS II after a 30 m (99 ft) dive as a result of holding breath inadvertently during decompression and eventually perforeming an emergency ascent. Without any delay, the tetraplegic patient was admitted to the nearest hyperbaric chamber administering tables 6a and 5 USN. After referral to our department, NMR imaging revealed punctiform lesions in the white matter of the brain and the cervico-thoracic spinal cord. In the thoracic CT scan we detected severe bullous changes, especially in the vena azygos lobe, most likely giving rise to pulmonary barotrauma with nearly fatal air-embolism during decompression. To our knowledge, no such coincidence has been described in the literature. Conclusions: A vena azygos lobe as a normal anatomical variant does not bear any pathogenic significance for the causation of pulmonary...


    2476/2523

    Tytuł oryginału: Atrioventricular block in pulmonary embolism.
    Autorzy: Ruiz-Bail‚n Manuel, Issa-Masad-Khozouz Ziad, Martinez-Diaz Juan Daniel
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.217-218, bibliogr. 6 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Massive pulmonary embolism (MPE) is a potentially fatal event that can occur at any age. A possible form of presentation is through a syncope, whereas the appearance of an atrioventricular (AV) block is exceptional. Although thrombolysis therapy is recognized to be efficacious in pulmonary embolism that courses with shock or cardiorespiratory instability, improving the situation, there has been no report to data of an AV block from an MPE that disappears after administration of thrombolysis. Case report: We describe a 35-year-old woman who developed a high-grade AV block from an MPE that progressed to shock. In the presented case, the AV block and shock symptoms disappeared after the administration of alteplase. Conclusions: Pulmonary embolism should be considered in the differential diagnosis of atrioventricular block. Evidently, the prognosis of the block will depend on the evolution of the MPE. Early thrombolytic therapy of the PE abates shock symptoms and may restore heart rhythm.


    2477/2523

    Tytuł oryginału: Glioblastoma multiforme following Bragg proton beam radiosurgery for cerebral arteriovenous malformation: complication or association?
    Autorzy: Ritz Rainer, Freudenstein Dirk, Bhring Udo, Krth Ulrich, Bornemann Antje, Duffner Frank
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.219-223, il., bibliogr. 30 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • neurologia
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: Stereotactic radiosurgery has become a widespread treatment alternative especially in benign centrakl nervous system lesions. So far, only a few cases of photon beam radiosurgery-induced oncogenesis have been reported. Case report: The authors report a patient who underwent Bragg proton beam radiosurgery through two bi-occipital portals for a surgically inaccessible left-sided occipital high-flow arteriovenous malformation (AVM). 19 years after irradiation, ther patient developed a mild left-sided hemiparesis together wity a progressive change of his mental status. Magnetic resonance imaging (MRI) demonstrated a predominantely cystic fronto-polar lesion on the right side. Neuropathological investigation after microsurgical resection revealed a glioblastoma multiforme (WHO IVú). Based on a through review of the literature, this constellation had not been described previously. Conclusions: Despite the common use of stereotactic radiosurgery in any application, the risk of delayed cerebral neoplasia reported to occur after fractionated irradiation still remains to be clarified. In the presented case, the caused relationship between proton beam radiosurgery and formation of a malignant brain tumors is discussed.


    2478/2523

    Tytuł oryginału: Tuberculosis of the parathyroid gland in a dialysis patient presenting as severe hypercalcemia.
    Autorzy: Al-Homrany Mohammed, Sabeel Abdalla, Malatani Tarek, Rabia Mahmoud, Mourad Nader, Alassad Abdulaziz
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.230-233, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Hypercalcemia in a dialysis patient may be caused by secondary hyperparathyroidism (SHPTH), adynamic bone disease (ABD), excessive use of calcium and Vit. D3 or granulomatous diseases. Tuberculosis (TB) is common among the dialysis population, however, the presentation is usually atypical and hence difficult HPTH and the possibility of parathyroidectomy. Case report: A 65-year-old dialysis patient presented with hypercalcemia and confusion. Parathyroid nodules were detected and parathyriodectomy revealed a caseating granulomatous reaction consistent with tuberculosis. Following parathyroidectomy and anti-TB treatment; the hypercalcemia resolved, other symptoms consistent subsided and the patient recovered the well-being with significant gain of dry weight. Conclusion: The patient presents a rare site of TB in the parathyroid glands causing severe hypercalcemia.


    2479/2523

    Tytuł oryginału: Acute intermittent porphyria with acute pancreatitis and liver dysfunction.
    Autorzy: Saruc Murat, Turkel Nurten, Yuceyar Hakan, Ayhan Semin, Demir Mehmet Akif, Can Mine
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.234-238, il., tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: We reported a case with acute intermittent porphyria who demonstrated acute pancreatitis and liver dysfunction. Case report: A 44-year-old white male with type II diabetes mellitus presented with colicky right upper quadrant and epigastric pain, nausea and vomiting during last two days. Two weeks prior to these complaints, he had and upper respiratory tract infection and used some drugs including terfenadine and co-trimoxazole. Physical examination revealed that he was mentally confused and he had jaundice. Abdominal examination revealed diffuse tenderness. Clinical, laboratory findings, liver histology, pancreas cytology and CT scan showed the presence of acute pancreatitis, mild liver failure and pleural effusion. His urine color was pink-purple and got darker in urine collection bag. Porphyrin studien revealed markedly elevated urine porphobilinogen, aminolevulinic acid, coproporphyrin, and uroporphyrin which suggested the diagnosis of acute intermittent porphyria. All these studies established the diagnosis of acute intermittent porphyria causing acute pancreatitis, mild hepatic failure pleural effusion and neurological signs. The patient was kept at rest and treated with total parenteral nutrition without allowing oral food intake. Large amount of glucose given by central venous route. A broad spectrum antibiotic was administered. Liver function, as well as clinical and laboratory finding of pancreatitis improved after two weeks of hospitalization. He has now been on follow-up for 6 months and he has not had any complaints. Conclusion: When a clinician...


    2480/2523

    Tytuł oryginału: Posterior mediastinal mature cystic teratoma.
    Autorzy: Eroglu Atilla, Kurkcuoglu Ibrahim Can, Karaoglanolu Nurettin, Erdogan Fazli, Gorguner Metin
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.242-244, il., bibliogr. 6 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • płeć męska

    Streszczenie angielskie: Background: Mediastinal mature teratoma is a rare primary germ cell neoplasm composed of welldifferentiated tissues derived from more than one of the three embryonic germ cell layers. Almost all mediastinal teratomas are found in the anterior mediastinum. Only eighteen posterior mediastinal teratomas have been reported to data in the literature. They have an excellent prognosis if tumor resection is complete and no immature tissue is present in the tumor. Case report: We describe a case of a two month-old baby boy who developed a mature cystic teratoma in the posterior mediastinum, successfully treated by surgical excision. The incidence, etiology and diagnostic procedure of the posterior mediastinal teratoma is discussed. Conclusions: Mature cystic teratomas of the posterior mediastinum are distinct clinical entity that must be considred when caring for a patient with a posterior mediastinal mass. Because of surrouding vital structures the cyst should be treated without delay.


    2481/2523

    Tytuł oryginału: Severe toxic encephalopathy with corpus callosum demyelination.
    Autorzy: Pokryszko-Dragan Anna, Bieszczad Małgorzata, Bilińska Małgorzata
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.245-249, il., tab., bibliogr. 10 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Marchiafava-Bignami disease (M.-B.) is one of the rarer toxic encephalopaties due to alcohol abuse. The most chracteristic feature of this disorder is demyelination of the corpus callosum. The disease usually takes a subacute course and leads to death. To date, the diagnosis has been established most frequently on the basis of autopsy. Case report: The authors present a case of severe toxic encephalopathy (in a patient with chronic excessive alcohol intake). The clinical presentation included: disturbances of consciousness and intellectual degradation, elements of neglect syndrome, seizures, gait and posture abnormalities, symptoms of pyramidal tract damage. Imaging of the CNS, demonstrating corpus callosum demyelination, played an important role in diagnostics. Atypical, favorable outcome of the disease is noteworthy. Conclusions: Advances in CNS imaging techniques allow curently intravital diagnostics of M.-B. disease. Remission of some clinical symptoms and lesions demonstrated by imaging techniques in the course of the disease is possible.


    2482/2523

    Tytuł oryginału: A rare case of Wegener's Granulomatosis localized in genitals.
    Autorzy: Witczak Władysław, Szubstarski Franciszek, Zwolski Dariusz, Kot Krzysztof, Łoza Magdalena, Oworuszko Danuta
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.250-253, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Wegener's Grannulomatosis is a multiogran disease. It includes angiitis, focal necrosis and specific granuloma in tissues and organs involved. The clinical manifestation mainly comprises symptoms from respiratory tract and kidneys. Wegener's Granulomatosis is rarely localized in genitals. Case report: The case report a fifty one-year-old woman with multiorgan localization Wegener's Granulomatosis, including genitals. The patient was hospitalized because of bleeding from reproductive organs and other complaints lasting for a year. Histopathological examination of numerous sections of uterine cervix and mucous nasal membrane allowed diagnosis. Conclusions: In case of erosive and ulcerative lesions in genitals the diagnosis of Wegener's Granulomatosis should be taken into consideration and numerous deep section should be taken for histopathological examinations.


    2483/2523

    Tytuł oryginału: Inflammatory tinea barbae due to Trichophyton rubrum infection -autoinoculation from fingernail onychomycosis?
    Autorzy: Szepietowski Jacek C., Bielicka Ewa, Maj Joanna
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.254-256, il., bibliogr. 12 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Tinea barbae is usually by zoophilic dermatophytes. Here, we present a rare case of an inflammatory linea barbae due to antropophilic dermatophyte - Trichophyton rubrum. Case report: An 87-year-old patient presented with several inflammatory plaques with pustules and crusts on their surface located on the bearded areas of the face (chin, cheeks and upper lip). Direct mycology from the lesions was positive. Culture revealed Trichophyton rubrum. Moreover, the patient suffered from fingernail and toenail onychomycosis also caused by Trichophyton rubrum. Thus, it was suggested that the infection of the face could be autoinoculated from diseased nails. Conclusions: This paper demonstrates that antropophilic dermatophytes, including Trichophyton rubrum, may be responsible for inflammatory kerion-like tinea barbae.


    2484/2523

    Tytuł oryginału: Racemose hemangioma of the retina.
    Autorzy: Stopa Marcin
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.257-259, il., tab., bibliogr. 9 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • okulistyka
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: Racemose hemangioma of the retina is an arteriovenous malformation of the fundus vessels. An ophthalmological examination of the fundus reveals multiple dilated vessels. Arteries communicate direvtly with veis without intervening capillary beds. This condition is considered to be congenital, nonhereditary, and without sex or race predilection. Other vascular malformations may be present elsewhere in the body, especially in the central nervous system. This combination is termed Wyburn-Mason syndrome that is also known as Bonnet-de Chaume-Blanc syndrome. Case report: A case of racemose hemangioma of the retina in a 24-year-old female patient has been reported here. Conclusion: Patients with arteriovenous malformations of the fundus vessels require further diagnostic procedures to exclude presence of potentially dangerous malformations within the central nervous system.


    2485/2523

    Tytuł oryginału: Congenital lobar emphysema - 2.5-year follow-up of a boy treated in the neonatal period with bronchoscopic bronchial lumen obstruction.
    Autorzy: Torbus Onufry, Dzielicki Józef, Jachimowicz Magdalena, Pikiewicz-Koch Anna, Mielczarek Maria, Pięta Marcin, Głowacki Jan
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (4) s.260-263, il., bibliogr. 19 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • pediatria
  • pulmonologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • płeć męska

    Streszczenie angielskie: Background: The authors present the case of a neonate with congenital lobar emphysema treated with an atypical method. Case report: Progressive respiratory disturbances requiring resuscitation were present since the first moments of the patient's life. Chest X-ray revealed an excessively bright image of the right lung with mediastinal structures displaced to the left and signs of compression atlectasis of the other lung. After one week mechanical ventilation, improvement of respiratory function allowing spontaneous breathing was obtained. Bronchoscopy performed in the second week of life revealed a fissure-like stenosis of the middle lobe bronchus, due mainly to edema and folded mucosa. According to the scheduled treatment, after aspiration of bronchial secretion, the bronchial lumen was obstructed using a rubber stopper. The condition of the infant after procedure was good. Regression of emphysematous changes was observed during 2.5-year follow-up. The last control chest X-ray revealed normal ventilation of both lungs. Conclusion: Structural treatment of congenital emphysema is not obligatory. Conservative, bronchoscopic management is a safe and effective method of treatment in congenital lobar emphysema.


    2486/2523

    Tytuł oryginału: Disturbed pattern of collagen fibres in dentinal dysplasia type I.
    Tytuł polski: Zaburzona architektonika włókien kolagenowych zębiny w przebiegu dysplazji zębinowej typu I.
    Autorzy: Wojtowicz Andrzej, Chaberek Sławomir, Hulisz-Secomska Małgorzata, Yamauchi Mitsuo, Ostrowski Kazimierz
    Źródło: Dent. Med. Probl. 2002: 39 (2) s.169-175, il., bibliogr. 24 poz.
    Sygnatura GBL: 313,665

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska

    Streszczenie angielskie: The histological analysis of distribution of collagen fibres in the molar of the 15 year-old patient showing features typical for type 1 dentinal dysplasia (DD-I) is documented and described. In order to evaluate the distribution pattern of collagen fibres, we used a polarising microscope to photograph the Sirus-red stained undecalcified dentine sections in crossed analyzer and polarizer. The enhanced image of birefringent collagen fibres stained by Sirus-red shows the chaotic distribution of collagen bundles. In one field of view, the circular distribution of these fibres created even the "maltasian" cross, similar to the ones formed over Haversian systems. We described mathematically the "obvious" chaotic distribution of collagen fibres using Fourier analysis and calculating the fractal dimension value of their structural pattern. It is concluded that the unusual mineralization pattern seen in the DD-I dentin is due in part to the primary error in synthesis and spatial distribution of collagen fibres.


    2487/2523

    Tytuł oryginału: Changeability of emissary vein foramina based on modern skull material.
    Tytuł polski: Zmienność otworów żył wypustowych badana na materiale czaszek współczesnych.
    Autorzy: Borysławski Krzysztof, Kurley Wiesław, Gworys Bohdan
    Źródło: Dent. Med. Probl. 2002: 39 (2) s.177-182, tab., bibliogr. 13 poz., streszcz.
    Sygnatura GBL: 313,665

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Cel pracy. Żyły wypustowe są jednym z ważniejszych połączeń układu żylnego wewnątrzczaszkowego i zewnątrzczaszkowego. Celem badań jest określenie zmienności położenia otworów żył wypustowych (sutkowych, ciemieniowych, kłykciowych, skrzydeł większych kości klinowej, klinowych i potylicznych) oraz ich kształtu, wielkości, liczebności i połączeń z otoczeniem. Badania te mogą mieć znaczenie praktyczne z medycznego punktu widzenia i stanowić przyczynek do określania zmienności cech epigenetycznych (przy porównywaniu podobnych cech na czaszkach średniowiecznych). Wcześniejsze opracowania opierały się na materiałach o małej liczebności, dotyczyły różnych populacji i posługiwano się różnymi metodami badawczymi. Materiał i metody. Badania przeprowadzono na 340 czaszkach osobników dorosłych (204 płci męskiej i 136 płci żeńskiej) pochodzących ze zbiorów Katedry i Zakładu Anatomii Prawidłowej AM we Wrocławiu. Określano (na różnej liczebności) średnicę otworów wypustowych za pomocą specjalnie skonstruowanego przymiaru - kalibrowanego stożka, którego umieszczenie w badanym otworze dawało możliwość natychmiastowego odczytu w określonym przedziale wartości. Na tej podstawie przeprowadzono własną klasyfikację wielkości omawianych otworów. Porównując uzyskane wyniki z badaniami innych autorów, dokonywano ich interpolacji. Wyniki i wnioski. Stwierdzono dużą zmienność międzypopulacyjną w występowaniu, liczebności i położeniu otworów żył wypustowych. Zaobserwowano nieznaczne różnice ...

    Streszczenie angielskie: Objectives. The emissary vein foramina (mastoid foramen, parietal foramina, condylar canal, emissary vein foramina of great wings of the sphenoid bone and occipital bone) constitute one more important junctions of the intracranial venous system with the external one. The research might have practical significance from the medical point of view and constitute the contribution to the deternimation of medieval ossous material. Due to a small range of the previous elaboration and significant interest in the subject, we review some information and compare the results of both research papers. Material and methods. The research was conducted on 340 adult individuals (204 male and 136 female ones) coming from the collection of Department Anatomy of Wroclaw Medical University. Results and conclusions. The analyzed data concerning the frequency of occurrence, position, number and dimensions of the emissary vein foramina are characterized by great differentiation and show interpopulation differences. There are no clearly oriented bilateral differences of the examined characteristics (symmetrically shaped characteristics previal). In the case of asymmetry, the larger foramina are observed most frequently on the right side. Significant sex differences were found with regared to the topography of the examined foramina. Higher categories of mostoid foramina and the foramina on the temporal surface of great wing of the sphenoid bone occur more frequently on male skulls. The ...


    2488/2523

    Tytuł oryginału: The influence of selected risk factors on the clinical condition of patients with periodontal disease - an evaluation of cytokine level in peripheral blood.
    Tytuł polski: Wpływ wybranych czynników ryzyka na stan kliniczny pacjentów z chorobą przyzębia - ocena stężenia cytokin we krwi obwodowej.
    Autorzy: Górska Renata, Kowalski Jan, Gregorek Hanna, Madaliński Kazimierz
    Źródło: Dent. Med. Probl. 2002: 39 (2) s.183-188, il., tab., bibliogr. 22 poz., streszcz.
    Sygnatura GBL: 313,665

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. Badania ostatnich lat wskazują na ścisły związek między chorobą przyzębia a wydolnością odpowiedzi immunologicznej. Zidentyfikowano również czynniki ryzyka choroby przyzębia. Spośród nich najbardziej znaczącym wydaje się nikotynizm. Cel pracy. Analiza wpływu palenia i rodzinnego występowania choroby przyzębia na stężenie cytokin pro- i przeciwzapalnych we krwi obwodowej osób z chorobą przyzębia zależnie od występowania czynników ryzyka zapalenia przyzębia. Materiał i metody. Badanie przeprowadzono na grupie 33 osób z chorobą przyzębia. Badano stężenia cytokin pro-(IL-1á, TNF-ŕ, INF-ç) i przeciwzapalnych(IL-4, IL-10, TGF-á) we krwi obwodowej i ich zależność od czynników ryzyka choroby przyzębia (palenie, rodzinne występowanie choroby przyzębia) w porównaniu z wynikami uzyskanymi od 10 zdrowych osób (grupa kontrolna). Wyniki i wnioski. Zaobserwowano różnice między badanymi grupami, nie były one jednak statystycznie znamienne. Mogło to być wynikiem stosunkowo małej liczebności grupy badanej oraz dużych odchyleń wartości stężeń cytokin w grupie pacjentów.

    Streszczenie angielskie: Background. Studies presented over the last decade indicate a close relationship between periodontitis and the efficiency of the immune response. Furthermore, several risk factors for periodontal disease have been identified. Among those risk factors, smoking may be of the greatest significance. Objectives. To analyse the influence of smoking and familial occurrence of periodontitis on the levels of pro- and anti-inflammatory cytokines in the peripheral blood of individuals with periodontal disease due to the presence of the risk factors. Material and methods. The study was conducted on the group of 33 patients suffering from periodontal disease. Pro- (IL-1á, TNF-ŕ, INF-ç) and anti-inflammatory (IL-4, IL-10, TGF-á) cytokine concentrations in the peripheral blood, and their dependence on risk factors for periodontal disease (smoking, familial predisposition as assessed by the medical history) were evaluated and compared with the results obtained from 10 healthy individuals (control group). Results and conclusions. Although differences were observed between the groups studied, there were not found to be statistically significant. This may be the result relatively small number of patients studied, as well as being the effect of great variations in concentrations of cytokines between patients.


    2489/2523

    Tytuł oryginału: Epidemiological studies on functional models of occlusion in natural dentition.
    Tytuł polski: Badania epidemiologiczne nad modelami funkcjonalnymi okluzji w uzębieniu naturalnym.
    Autorzy: Panek Halina
    Źródło: Dent. Med. Probl. 2002: 39 (2) s.189-193, il., tab., bibliogr. 26 poz., streszcz.
    Sygnatura GBL: 313,665

    Hasła klasyfikacyjne GBL:
  • stomatologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Wprowadzenie. Wybór najodpowiedniejszej koncepcji okluzji do celów rehabilitacji protetycznej pacjentów z częściowymi brakami zębów ciągle budzi wiele kontrowersji. Ocena występowania modeli okluzji w uzębieniu naturalnym mogłaby przyczynić się do rozwiązania tego trwającego niemal 100 lat problemu w protetyce stomatologicznej. Cel pracy. Określenie występowania modeli zgryzu w uzębieniu naturalnym w zależności od płci i wieku. Materiał i metody. Badano grupę 834 pacjentów z pełnym uzębieniem naturalnym wyłonioną z populacji pacjentów badanych profilaktycznie w Dolnośląskim Centrum Diagnostyki Medycznej "Dolmed". Wiek badanych wahał się 20-63 lat. U wszystkich badanych pacjentów przeprowadzono kliniczną analizę czynności narządu żucia, która pozwoliła na rozpoznanie poszczególnych modeli okluzji. Istotność znalezionych wyników badań oceniono metodami statystycznymi. Wyniki. W badanej populacji stwierdzono następujące typy okluzji: zabezpieczoną dwustronnie i jednostronnie przez kły, z grupową funkcją zębów bocznych, zrównoważoną i "inne". Częstość poszczególnych modeli okluzji była niemal jednakowa u mężczyzn i kobiet, ale niektóre były zależne od wieku. Częstość okluzji dwustronnie i jednostronnie zabezpieczonej przez kły malała z wiekiem, a częstość okluzji z grupową funkcją zębów bocznych rosła. Częstość okluzji zbalansowanej i "innej" była niska i nie zmieniała się z wiekiem. Wnioski. Okluzja z grupową funkcją zębów bocznych wydaje się modelem najbardziej ...

    Streszczenie angielskie: Background. There have been still great controversies on selecting the most appropriate occlusal scheme for prosthetic rehabilitation of patients with partial loss of teeth. That almost 100-year dilemma in prosthodontics seems to be solved by studying the natural models of occlusion. Objectives. Aim of this study was to determine the prevalence of functional models of occlusion in natural dentition and their relationship to sex and age. Material and methods. Material consisted of 834 subjects with complete natural dentition. The group of subjects was selected from the patients who underwent a prophylactic examinations in The Lower Silesia Medical Center "Dolmed". The age of the examined subjects ranged from 20 to 63 years. In all the subjects, the functional models of occlusion were recognized on the base of clinical examination of the masticatory system. Results. The following models of occlusion were found: bilateral and unilateral cuspid-protected occlusions, group-function occlusion, balanced occlusion and "others". The prevalence of particular models of occlusion was almost the same in male and female, however, some of the models were dependent on age. The frequency of bilateral and unilateral cuspid-protected occlusion decreased with age, while the frequency of group-function occlusion increased. The frequencies of balanced occlusion and "other" types of occlusion were very low and remained nearly the same in relation to age. Conclusion. The group function ...


    2490/2523

    Tytuł oryginału: The Second International Symposium on Herpes and Retroviruses - oncogenic viruses and oncogenesis.
    Opracowanie edytorskie: Roszkowski Jacek (Ed.).
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.1-199, il., tab., bibliogr. [przy ref.]. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny


    2491/2523

    Tytuł oryginału: Proteins that influence apoptosis in B-cell chronic lymphocytic leukemia.
    Autorzy: Filip Agata, Marzec Barbara, Koczkodaj Dorota, Kubiatowski Tomasz, Grabek-Gawłowicz Małgorzata, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.3-8, tab., bibliogr. 24 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • hematologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study we estimated the expression of apoptosis-regulating genes in freshly isolated peripheral blood lymphocytes from patients diagnosed with B-CLL, and in the cells suibjected to 72-hrs culture with/without the factors that induce cell proliferation. We investigated the tumor supressor gene p53, the caspases (caspase-3, caspase-7, caspase-8), the protooncogene bcl-2 and IAP family genes (survivin, cIAP-2). Immunocytochemistry and RNase Protection Assay (RPA) were employed to assess both protein and mRNA. We found high levels of expression of antiapoptotic genes cIAP-2 and bcl-2 in most patients. Despite the presence of its protein product in 23 p.c. of the cells ex vivo, there was no detectable survivin mRNA in these cells. The increase in survivin mRNA expression was noted in the cells induced to proliferation. The level of caspases expression in B-CLL lymphocytes seemed to be similar to the level observed in the cells isolated from healthly volunteers.


    2492/2523

    Tytuł oryginału: Prevalence of Human papillomavirus infection in women with low grade squamous intraepithelial lesions (LSIL).
    Autorzy: Friedek Daniela, Chełmicki Zbigniew, Romanik Małgorzata, Ekiel Alicja
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.9-14, il., tab., bibliogr. 24 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • pediatria
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: The purpose of the study was to determine frequent occurrence of low and high oncogenic HPV types infections in women population with cytological diagnosed LSIL and without abnormalities in cytology. The material of the study were swabs applied to the vaginal part of uterine cervix and cervical canal, taken from 221 women (age 17-53 years). The presence of HPV DNA was determined by hybrid capture method; for low oncogenic risk HPV types (6/11/42/43/44) and for high oncogenic risk HPV types (18/31/33/35/45/51/52/56) separately. In women wioth normal cytological smears, the frequency of delitescent infections with high oncogenic HPV types in age range below 30 years was 6.1 p.c. and above 30 years was 4.5 p.c. The infection rate with high oncogenic HPV types in aged below 30 years with LSIL was 40.4 p.c. and above 30 years was 22.9 p.c. The genetic methods of detecting HPV are diagnostically useful for the completion of cytological diagnosis.


    2493/2523

    Tytuł oryginału: Coinfection of low and high oncogenic human papillomavirus types in women with condylomata acuminata. Preliminary raport.
    Autorzy: Friedek Daniela, Ekiel Alicja, Romanik Małgorzata, Chełmicki Zbigniew
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.15-18, tab., bibliogr. 16 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • ginekologia i położnictwo
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Condylomata acumminata are begin pathological alterations caused mainly by low oncogenic HPV types. The purpose of the study was to determine the occurrence of infection with low and high oncogenic HPV types in women with condylomata acuminata. The swabs taken from pathological alternations clinically described as conndylomata acuminata, from vaginal part of the uterine cervix and cervical canal were investigated. Samples were taken from 17 women, age 20-36 years. The presence of the HPV DNA was determined by the hybrid capture method for low and high oncogenic HPV types, separately. In 12 (70 p.c.) out of 17 women a connection was confirmed between the vaginal and cervical canal warts and human papilloma virus infections. In 7 cases coexisting infection with both low and high oncogenic HPV types were ascertained.


    2494/2523

    Tytuł oryginału: Detection of Epstein-Barr virus and immunohistochemical studies in cases of undifferentiated carcinoma with lymphoid stroma of the parotid gland and the uterine cervix.
    Autorzy: Jarosz Bożena, Kocki Janusz, Korobowicz Elżbieta, Wojcierowski Jacek, Starosławska Elżbieta
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.19-24, il., bibliogr. 21 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Lymphoepithelioma is a relatively common malignancy in the nasopharynx. Undifferentiated carcinomas with lymphoid stoma (limhoepithelioma-like carcinomas) of the other organs are very rare. Here we report two cases of such tumours originating in the parotid gland and the uterine cervix. Histologic examination showed nests of undifferentiated epithelial cells (CK+, Vim-) with abundant lymphocytes (predominantly CD+ T cells), plasma cells (Plasma Cell Marker+) and macrophages (CD68+) in and around the tumor cellnests. The Epstein-Barr virus (EBV) genome was detected by in situ hybridization in section from tumour of the parotid gland. The limphoepithelioma-like carcinoma of the salivary gland is often associated with EBV infection. In situ hybridization for the detection of the EBV in malignant epithelial cells was negative in section of uterine cervix.


    2495/2523

    Tytuł oryginału: Mutattion of Ki-ras gene and infection by human papilloma virus in cervical pathology.
    Autorzy: Kamiński Kazimierz, Waksmański Bogdan, Cieślak-Steć Małgorzata
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.25-31, tab., bibliogr. 15 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • pediatria
  • genetyka
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: The purpose of the study was to assess the prevalence of c-Ki-ras oncogene mutations in relation to infections of highly oncogenic human papillomavirus types for abnormal results of cytological examination. The HPV was detected in 213 females (45 p.c. of the tested population). Some mutations of the c-Ki-ras gene could be found in 47 (10 p.c.) females. A high percentage of mutations was observed in a group of female patients with HG SIL and squamous epithelium carcinoma: 29 p.c. and 44 p.c., respectively. The prevalence assessment of Ki-ras oncogene mutations may may help explain some doubtful cytological specimens. Confirmed was the existence of a relation of individual cervical dysplasia degrees and carcinoma to the presence of highly malignant oncogenic HPV and Ki-ras mutations.


    2496/2523

    Tytuł oryginału: Co-expression of Epstein-Barr virus latent membrane protein 1, Bcl-2, Bcl-xl, p21 cip1 and p53 genes in human lymphoepithelial carcinoma.
    Autorzy: Kocki Janusz, Jarosz Bożena, Constantinou Maria, Korszeń-Pilecka Iwona, Pliecki Marek, Antosz Halina, Starosławska Elżbieta, Korobowicz Elżbieta, Kałużewski Bogdan, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.33-37, il., bibliogr. 16 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Activation of latent genes of Epstein-Barr virus (EBV) protects human cells from apoptosis and can induce the expression of bcl-2 gene, a survival factor and inhibitor of apoptosis. We used in situ hybridization technique to detect of EBV LMP1, Bcl-2, Bcl-xL, p21 Cip1 and p53 genes expression in paraffin-embodded tissue from patient with a very rare lumphoepithelial carcinoma (undifferentiated carcinomas with lymphoid stoma) of parotid gland. We detected expression of LMP1, bcl-xL and strong signals from bcl-2. We did not detect signals of p53 and p21 Cip1. We have fixed a potent mechanisms of development of a parotid gland carcinoma: EBV infection or/and LMP1 activation - overexpression of bcl-2 and bxcl-xL - decreased expression of p53 and p21 Cip1 - immortization of cells - cancer.


    2497/2523

    Tytuł oryginału: Clonal distribution of trisomy 12 and 13q14, TP53 deletions in chronic lymphocytic leukaemia.
    Autorzy: Koczkodaj Dorota, Wąsik-Szczepanek Ewa, Filip Agata, Kubiatowski Tomasz, Grabek-Gawłowicz Małgorzata, Marzec Barbara, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.39-44, tab., bibliogr. 26 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • genetyka
  • hematologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Although chronic lymphocytic leukaemia (CLL) is the most common leukemia in adults, little is known about the molecular abnormalities underlying it and their prognostic significance. We used fluorescence in situ hybridization (FISH) to evaluate the occurrence of 13q14 deletions, trisomy 12 and deletions in 17p13 in chronic lymphocytic leukemia.


    2498/2523

    Tytuł oryginału: CD4+ and CD8+ T cells and soluble interleukin-2 receptor (sIL-2R) levels in patients with infectious mononucleosis.
    Autorzy: Krzowska-Firych Joanna, Tomasiewicz Krzysztof, Fota-Markowska Hanna, Modrzewska Roma
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.45-50, tab., bibliogr. 24 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • immunologia
  • choroby zakaźne
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study was to assess the percentage of T lymphocytes with a surface phenotype CD4+ and CD8+ in patients with acute symphomatic phase of infectious mononucleosis, and the serum sIL-2R level in patients with infectious mononucleosis and healthly individuals. In the present study we have demonstrated the percentage of CD8+ cells during an acute phase of infectious mononucleosis was twice as high as in control group. The percentage of CD4+ was three times smaller than in healthly individuals. We have also observed the intense increase of soluble IL-2 receptor serum level, which can be regarded as CD8+ cells activation marker.


    2499/2523

    Tytuł oryginału: Assessment of MMP-2 and MMP-9 expression in LPS stimulated LS180 cell line.
    Autorzy: Kubiatowski Tomasz, Korzeniowska-Olszańska Joanna, Różyńska Krystyna, Filip Agata, Marzec Barbara, Gawłowicz Małgorzata, Koczkodaj Dorota, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.51-56, il., bibliogr. 16 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Matrix metalloproteinases (MMP) are a large family of hydrolases contributed to both normal and pathological tissue remodeling. There is an accumulated data showing that bacterial lipopolisaccharide can stimulate MMPs expression in many models in vitro. The aim of this study was to assess the MMP-2 and 9- expression in LS 180 cell line stimulated with LPS in dose of 0.14 ćg/ml. Into our experimental work we employed many different techniques such as: RT-PCR, fluorescent immunocytochemistry and zymography. According to our data there were no differences in MMP-2 and MMP-9 expression as was shown by means of RT-PCR and fluorescent immunocytochemistry. Because immunocytochemistry was not able to distinguish active and inactive forms of metalloproteinases zymography was incorporated to measure amounts of different forms of MMP-2 and MMP-2 secreted to culture medium. Assessment of the obtained results showed slightly elevated level of proMMP-9 and MM-9 after LPS stimulation. For MMP-2 similar effects was not seen.


    2500/2523

    Tytuł oryginału: Diagnosis of EBV infection - methods, problems and interpretation of results.
    Autorzy: Litwińska Bogumiła, Trzcińska Agnieszka
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.57-63, tab., bibliogr. 18 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The diagnostic value of two tests (ELISA and IFA) to detected EBV infection was compared. The presence of specific IgM an IgG antibodies for different EBV antigens (VCA, EA, EBNA) was studied. Interpretation of EBV infection in both of the tests used was the same only in 20 samples out of 38 tested (52.63 p.c.). The discordance in results between ELISA and IFA concerned the frequency of antibody detection as well as their patterns. High number of discortant results was observed in detection of VCA-IgG an EA-IgG. These divergences were the reason for different interpretation of type of EBV infection (primary, past, reactivation of latent infection).


    2501/2523

    Tytuł oryginału: EBV - infected LCL and B-CLL exhibit different expression pattern of p27 and Rb genes family.
    Autorzy: Marzec Barbara, Kubiatowski Tomasz, Gawłowicz Małgorzata, Szczęśniak Dorota, Filip Agata, Koczkodaj Dorota, Nesina Iryna, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.65-70, il., bibliogr. 18 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • hematologia
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Epstein-Barr (EBV) is a powerful immortalizing virus for human B lymphocytes in vitro and is assoxciated with several human neoplasms in vivo. Chronic lymphocyte leukaemic (CLL) cells might be infected by the virus but can not proliferative whereas normal resting B lymphocytes produce immortalized cell lines after infection. Since the pRb,p 107 and p130, together with p27, play critical roles in controlling the mammalian cell division cycle, we have investigated the expression of this genes following EBV immortilisation of primary B-lymphocytes comparing to cultured B-CLL cells. In this report, we show that EBV decreases the pRb and p130 mRNA gene expression and drives down the mRNA level of p27 gene expression, which is extremely high in B-CLL lymphocytes. This is achieved by a strategy involving "silencing" of critical cell division cycle genes: pRb, p130. Viral proteins may take part in that process. Increased expression of p27 in B-CLL cells may be responsible for maintenance of anergic state.


    2502/2523

    Tytuł oryginału: Prevalence of Human Papillomavirus (HPV) and Herpes Simplex Virus type 2 (HSV-2) in cervical dysplasias and carcinomas.
    Autorzy: Pochylski Tomasz, Kwaśniewska Anna
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.71-75, tab., bibliogr. 15 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • mikrobiologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: Using PCR methods HPV incidence was evaluated including type 16 and 18, as well as Herpes genitalis in paraffinised section from women that underwent surgery to either squamous cell cervical cancer or high degree dysplasia. It was statistically proven that incidence of HSV-2 was significantly higher in a group of patients with carcinoma planoepitheliale colli uteri. In the study and control groups no correlation was found between the occurrence of HPV and Herpes virus genitalis.


    2503/2523

    Tytuł oryginału: Differences in activation PMBC for interferon alpha production depending on the virulence of used herpes simplex virus type 1 strains.
    Autorzy: Rechnio Magdalena, Litwińska Bogumiła
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.77-83, il., bibliogr. 17 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • in vitro

    Streszczenie angielskie: Cytokines, especially type I IFNs (IFN alpha and IFN beta) play an important tole in controlling acute HSV-1 infection. The purpose of the present study was to determine the relation between the virulence of used HSV-1 strains and IFN production. PBMC was stimulated by temperature sensitive (ts) and temperature resistant (tr) mutants of HSV-1. HSV-1 ts, earlier described as less virulent for mice, stimulated hyperproduction of IFN alpha. We established that it was connected with presence of a great number of defective particles in HSV-1 ts population. HSV-1 tr, earlier described as more virulent for mice, stimulated in a lover degree IFN alpha production than the native strain.


    2504/2523

    Tytuł oryginału: CMV infection in persons with atherosclerotic lesions in coronary arteries.
    Autorzy: Siennicka Joanna, Żuk Anna, Krajewski Paweł, Litwińska Bogumiła
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.85-89, il., tab., bibliogr. 19 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The purpose of this work was to evaluate the relationship between pathological changes and presence of CMV DNA in atherosclerosis plaques in wall of coronary vessels. The presence of CMV DNA was investigated by nested PCR in atherosclerotic lesions and unchanged site of a vessel taken postmortem from the same person. Also the serum samples were investigated for the presence of anti-CMV-IgG and IgM antibodies by ELISA and CMV DNA by nested PCR. Intensity of atherosclerosis was evaluated by postmortem examination with 5 point scale. Atherosclerotic changes with different intensity were observed in 30 out of 35 examined persons. CMV DNA was found in 30 p.c. of vessels with lesion, but was not in arterial walls of patients without atherosclerosis (grade O). Intensity of atherosclerotic changes was correlated with age and anti-CMV IgG level, but small number of cases with high advanced changes (II-IV grade) did not allowed a more precise analysis.


    2505/2523

    Tytuł oryginału: HCMV infection-problems of laboratory diagnosis.
    Autorzy: Siennicka Joanna, Żuk Anna, Rechnio Magdalena, Litwińska Bogumiła
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.91-96, il., bibliogr. 23 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: This paper contains review of materials, patients' group and methods used in diagnosis of HCMV in routine practice in Department of Virology, National Instutute of Hygiene. In the period January 2000 - April 2002 altogether 773 cases underwent diagnostic analysis. Analyses of immunocomponent persons tested in order to confirm infection or determine the immunological status, patients after transplantation, and women in the procreative period with suspected HCMV infection constituted 94.1 p.c. of the entire group. The materials from patients were investigated using ELISA, shell vial, OIF, pp65 and PCR methods. The results and diagnostic value of different methods were discussed.


    2506/2523

    Tytuł oryginału: Relationship between HPV 16 DNA presence in invasive squamous cell carcinomata of the uterine cervix and their metastases.
    Autorzy: Słodziński Hubert, Szepietowska Magdalena, Polz-Dacewicz Małgorzata, Putowski Lechosław, Ćwierz Edward
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.97-100, tab., bibliogr. 9 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • genetyka
  • onkologia
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Paraffin-embedded specimens of primary cervical carcinomata and their nodal metastases were obtained from eight patients. They were analyzed for the presence of human pappilomavirus (HPV) type 16 using the polymerase chain reaction (PCR). HPV DNA was detected in seven of the eight patients and was present in both primary and metastatic tumours in five of these seven cases. These results suggest that HPV 16 does not continue to confer and selective advantage on the meatastaic cells which carry it.


    2507/2523

    Tytuł oryginału: D type cyclins mRNA expression pattern in human acute leukaemia cells.
    Autorzy: Szczęśniak Dorota, Kocki Janusz, Cioch Maria, Dmoszyńska Anna, Marzec Barbara, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.101-104, tab., bibliogr. 19 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • onkologia
  • hematologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The cell cycle alternation may cause malignant cell tranformation. The past several years' research has resulted in defining new agents participating in cell proliferation and contributed to the fact that we have started to understand the cell cycle machinery. Molecules involved in basic pathway of cell division are cyclins, the positive regulators of cell cycle, overexpression of which is associated with uncontrolled cell growth and cancer. In our reasearch we examined the level of cyclin genes expression in bone marrow samples from 15 patients with acute leukaemia before therapy. For the detection of cyclin mRNA we used. The Multi-Probe RNase Protection Assay System (Pharmingen). We focused on the expression of D type cyclins. The results we obtained show that leukaemic cells reveal significantly high levels of cyclin D2 and D3 mRNA in majority of examined samples as well as difference in expression of cyclin D1 between ALL and AML cells. The correlation between the clinical data and expression of cyclin genes in hematological malignancies may be a prognostic factor for the relapse or poor prognosis.


    2508/2523

    Tytuł oryginału: mRNA expression of the cyclins in B-CLL.
    Autorzy: Antosz Halina, Kowal Małgorzata, Kwiatkowska-Drabik Barbara, Marzec Barbara, Jargiełło Małgorzata, Mizerski Grzegorz, Kocki Janusz, Wysocka Krystyna
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.105-110, il., tab., bibliogr. 13 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: B cell chronic lymphocytic leukemia is malignant disorder characterised by accumulation of resting lymphocytes. We investigated the mRNA expression of cyclins A, B, C, D1, D2 and D3, which are characteristic for different phases of the cell cycle, by multi-probe RNase protection assay system. We have examined expression of cyclins in unstimulated and stimulated PMA and LPS lymphocytes in vitro. In our study, all B-CLL tested samples expressed the mRNA cyclin C, D1, and overexpression D2 after stimulation PMA. mRNA cyclin A and D3 appeared in the cases where the cells proliferated in vitro. Induction of cyclin B expression was observed in only 5 cases B-CLL after treating with PMA and LPS.


    2509/2523

    Tytuł oryginału: Influence of two furocoumarins: bergapten and xanthotoxin from meadow cow parsnip (Heracleum sibiricum L.) on apoptosis induction and apoptotic genes expression in HL-60 human leukaemic cell line.
    Autorzy: Bogucka-Kocka Anna, Kocki Janusz
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.111-116, il., bibliogr. 13 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We analysed biological effect of bergapten and xanthotoxin on human leukaemic cell line - HL-60. The furocoumarins were isolated from a meadow plant - cow parsnip (Heracleum sibiricum L.). To investigate the furocoumarins - mediated effects, the HL-60 cells were incubated with different concentration of bergapten or xanthotoxin (1 ćM, 10 ćM, 50 ćM, 100 ćM, and 500 ćM). Living, apoptotic and necrotic cells were detected by Annexine V method. To monitor the genes expression we used hAPO-2c Template Set of RPA which consist of following Bcl-2 family genes probes: bclw, bcl-XL, bcl-XS, bfl 1, bad, bax, bcl-2, bik, mcl 1, L32, and GAPDH. We established IC50 values - 50 ćM of xanthotin and 100 ćM of bergapten. In our studies decreased expression of bcl-2, bcl-x, bad, bax (Bcl-2 family) and L32 and GAPDH genes (houskeeping) were observed, according to furocoumarins in cultures.


    2510/2523

    Tytuł oryginału: Detection of antibody against bovine leukaemia virus with Immunoperoxidase test (PLA).
    Autorzy: Buzała Ewa, Kubiś Piotr, Rułka Jan
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.117-120, tab., bibliogr. 16 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • weterynaria
  • onkologia
  • immunologia
  • hematologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • bydło

    Streszczenie angielskie: The immunoperoxidaese test (PLA) was found to be more sensitive than ID and ELISA for detection of antibodies against bovine leukosis. Examinations revealed 22 (73 p.c.) positive results in ID and 25 (83 p.c.) in ELISA while 27 (90 p.c.) were shown in PLA. In the effect, PLA is a very simple, specific and sensitive serological test for the diagnosis of bovine leukosis.


    2511/2523

    Tytuł oryginału: Expression of uPAR (urokinase plasminogen activator receptor), P-glycoprotein 170 and VCAM-1 (vascular cell adhesion molecule) on acute leukaemia cells.
    Autorzy: Cioch Maria, Hus Iwona, Jawniak Dariusz, Małek Magdalena, Mańko Joanna, Gorący Aneta, Dmoszyńska Anna
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.121-125, il., tab., bibliogr. 14 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Expression of uPAR on bone marrow blast cells examined by flow cytometry technique was significantly higher than on normal bone marrow mononuclear cells in the control group. There was correlation between uPAR expression and the expression of CD33, Pgp-170 and VCAM-1. THese results suggest that uPAR can participate in enhanced adhesion of leukaemic cells to tissues and resistance to chemotherapy.


    2512/2523

    Tytuł oryginału: Plasma and plasma cell surface measurements of urokinase plasminogen activator system in multiple myeloma patients.
    Autorzy: Dmoszyńska Anna, Cioch Maria, Walter-Croneck Adam, Jawniak Dariusz, Hus Iwona, Roliński Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.127-131, il., tab., bibliogr. 8 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In 80 unselected patients with newly diagnosed untreated multiple myeloma (MM) and 41 healthly subjects the cativity of urokinase plasminogen activator (uPA), its soluble and surface receptor (uPAR) and complex of uPA with its inhibitor (PAI-1) were assessed. We found significantly higher levels of these components comparing to the control group of healthly subjects.


    2513/2523

    Tytuł oryginału: Serologic markers of CMV infection in patients with chronic hepatitis C.
    Autorzy: Fota-Markowska Hanna, Lis-Tonder Joanna, Rajtar Barbara, Modrzewska Roma, Polz-Dacewicz Małgorzata, Ziaja Marta
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.133-139, tab., bibliogr. 18 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • choroby zakaźne

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this study was to assess the frequency of occurrence of antibodies anti-CMV IgM and anti-CMV IgG in patients with chronic hepatitis C. The study group comprised 60 patients. For the presence of specific anti-CMV IgM and IgG antibodies sera were examined with ELISA method and commercial sets of chemicals Organon Teknika. The presence of HCV-RNA in sera was detected with RT-PCR method according to the Murex procedure. Conclusions: 70 p.c. of examined patients had serologic markers of CMV infection and 5 p.c. of them had both classes of antibodies against CMV. There was not interdependence between the level of HCV-RNA and the titre of antibodies anti-CMV IgG in sera of our group of patients.


    2514/2523

    Tytuł oryginału: Urokinase plasminogen activator (uPA) and soluble urokinase plasminogen activator receptor (suPAR) serum level in patients with malignant lymphomas.
    Autorzy: Hus Iwona, Cioch Maria, Jawniak Dariusz, Mańko Joanna, Dmoszyńska Anna, Chrapko Marek, Hus Marek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.141-144, il., tab., bibliogr. 11 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: uPA and uPAR system play an important role in tumour invasion and metastasis. The aim of the study was evaluation of uPA and suPAR serum levels in patients with malignant lymphomas. We found, that uPA and uPAR levels were elevated in malignant lymphoma patients, and these values correlated with disease activity parameters.


    2515/2523

    Tytuł oryginału: Survival of the patient with the small-cell lung cancer and the state of his immunological response. Short report.
    Autorzy: Krawczyk Paweł, Mackiewicz Barbara, Chocholska Sylwia, Milanowski Janusz
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.145-150, il., bibliogr. 10 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: In the moment of diagnosis, small-cell lung cancer (SCLC) is a generalised disease due to the metastatic spread. The antitumour cytotoxic immunological response may control the development of SCLC growth because of an easy contact with neoplasm antigens. The aim of the study was to evaluate the activity state of the cytotoxic T-lymphocytes (CTLs) in a 52-years-old male patient with a 24-month course of SCLC. In the research, the flow cytometric technique was used. The percentage of CTLs in our patient was two times higher (29,64 p.c.) comparing to other patients with SCLC (N=5; 9.90 p.c. ń 4.14 p.c.) and healthy donors (N=10; 9,34 ń 4.07 p.c.). The expression of FasL on the CTLs surface was 49.15 MFI in the patient with a long course of SCLC, 12,86 ń 1.81 MFI in other patients with SCLC and 14.62 ń 3.54 MFI in the control group. It seems that specific clones of CTLs generated in SCLC may have an influence on the prolongation of patient's survival.


    2516/2523

    Tytuł oryginału: Is the lung cancer among the hereditary malignancies?
    Autorzy: Krawczyk Paweł, Michnar Marek, Kieszko Robert, Król Anna, Wójcik Magdalena, Chocholska Sylwia, Milanowski Janusz
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.151-157, il., bibliogr. 17 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • genetyka
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cancer familial agregation (CFA) reflects an inherited predisposition to the development of the benign and malignant tumours. In the classification, the most frequent are the hereditary breast, ovarian and colerated cancers, while the hereditary lung cancer (HLC) is not fully defined as a disorders of a genetic ground. The research involved a group of 92 patients suffering from the lung cancer and one of 80 subjects with chronic obstructive pulmonary disease (COPD) as a control. Information from the questionnaire was used for drawing the genealogies considering the incidence of different types of cancers in the particular family. 19.55 p.c. families fulfilled criteria of CFA and 3.25 p.c. - of HLC in the lung cancer patients group. In contrast with the first group, only 3.75 p.c. families fulfilled the criteria of CFA and 1.25 p.c. families - of HLC in COPD patients group. The patients with lung cancer had greater overall risk of this cancer than the patients with COPD providing that the neoplams appeared in the first-degree relatives (OR=3.09, P=0.037). The crude odds ratio of lung cancer individuals having one family member with lung cancer was 2.25 in comparison with COPD subjects (P=0.05). On the basis of the results above, it can be assumed that the lung cancer may belong to the hereditary malignancies.


    2517/2523

    Tytuł oryginału: Percentage of B lymphocytes and the presence of CD21 receptor on lymphocytes in patients with infectious mononucleosis.
    Autorzy: Lis-Tonder Joanna, Fota-Markowska Hanna, Modrzewska Roma, Tomasiewicz Krzysztof
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.147-165, tab., bibliogr. 22 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • choroby zakaźne

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of this work was to assess the percentage of B lymphocytes and the presence of CD21 receptor on lymphocytes in patients with primary symptomatic infectious mononucleosis. The study group comprised 30 person: 10 healthy subjects as a control group and 20 individuals with infectious mononucleosis. Serum concentration of anti-VCA IgM was assessed to confirm the primary infection with EBV. The count of leucocytes and percentage of lymphocytes and atypical lymphocytes was examined as a routine tests. Polyvalent antibodies were used to identify B lymphocytes and monoclonal antibodies were used to detect lymphocytes with CD21. Conclusion: The symptomatic period of infectious monocleosis is charactetrised by 2,32 times bigger number of B lymphocytes and 2,68 times bigger number of lymphocytes with CD 21 receptor.


    2518/2523

    Tytuł oryginału: Impact of preoperative chemotherapy and/or antimicrobial prophylaxis on dynamics of nasopharyngeal microflora in patients with lung cancer during short-term hospitalization.
    Autorzy: Malm Anna, Głowniak-Korona Izabela, Kasprzycka Anna, Rybojad Paweł, Górniewski Grzegorz, Furmanik Franciszek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.167-170, tab., bibliogr. 7 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • pulmonologia
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Analysis of nasopharyngeal microflora in patients with lung cancer during short-term hospitalization, who routinely receive antimicrobial prophylaxis before pulmonary resection operations, suggests that preoperative chemotherapy can be regarded as an additional risk factor for colonization of upper respiratory tract with Gram-negative rods of the family Enteterobacteriaceae or with yeast-like fungi - Candida spp.


    2519/2523

    Tytuł oryginału: Expression of the p16 at mRNA and protein levels in B-CLL lymphocytes.
    Autorzy: Mizerski Grzegorz, Antosz Halina, Jargiełło Małgorzata, Dudzisz-Śledź Monika
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.171-175, il., bibliogr. 22 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Cyclin dependent kinases (CDKS) play an important role in control of the cell cycle of eucaryotic cells. The phases Go and G1 are controlled by CDK4 and CDK6. Inhibitor p16 blocks binding cdk4/6 with cyclins, and stops transition of G1/S. Overexpression of p16 stops the proliferation. The aim of this study was to determine the expression of INK4a/MTS1 gene, encoding p16 in lymphocytes from patients with B-cell chronic lymphocytic leukaemia (B-CLL). B-CLL is a disease with low proliferative activity of lymphocytes with the accumulation of lymphocyte clones, stopped in GO/G1. Expression of mRNA was examined according to RNA-ase Protection Assay (RPA). The presence of p16 protein was detected using monoclonal antibodies anti p16, labelled with fluorescein. Leukaemic immunopthenottype CD5/CD19 was present at more than 70 p.c. of cells in all examined cases. Expression of INK4a is lower in cells stimulated with mitogens than in quiescent cells.


    2520/2523

    Tytuł oryginału: Cytokines serum level in B-cell chronic lymphocytic leukaemia - do cytokines regulate malignant cell accumulation in vivo?
    Autorzy: Podhorecka Monika, Dmoszyńska Anna, Roliński Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.177-181, tab., bibliogr. 10 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • immunologia
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Since cytokines can regulate proliferation and apoptosis of leukemic cells and mediate interaction between malignant cells and other elements of immune system, they seem to be involved in pathogenesis and course of B-cell chronic lymphocytic leukaemia (B-CLL). Althrough most reports concern cytokines effects in vivo studies, far less is known about their role in vivo. The aim of this study was to detect the serum level of IL-2, IL-4 and IFNç in B-CLL patients indicating in vivo cytokine concentration and to determine whether the cytokine level of B-CLL patients differs from that of healthy controls. The cytokines concentration was assessed by enzyme-linked immunosorbent assay (ELISA). We detected statistically significant higher level of IFNç and IL-4 in patients group in comparison to controls. There was no statistically significant difference between both groups as far as IL-2 level was concerned. The obtained results indicate that cytokines playing the crucial role in suppression of malignant cells apoptosis in vitro are involved in such type of regulation in vivo, as well. Thus, some therapeutic approaches focusing on cytokines may be investigated.


    2521/2523

    Tytuł oryginału: Increase expression of gene of differentiation - E2F4 caused by sulindac derivatives in vitro correlated with apoptosis.
    Autorzy: Rudzki Sławomir, Korszen-Pilecka Iwona, Dudzisz-Śledź Monika, Wojcierowski Jacek
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.183-189, il., bibliogr. 28 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: E2F4 gene is a differentiation gene of the cell and the very early transcriptional factor for other genes including E2F4 and genes of apoptosis. Overexpression of E2F4 gene of decrease of pRB cause cell fast entering S phase of cell cycle and apoptosis. In the presented paper we determine the influence of sulindac sulfide and sulfone dervatives on E2F4 expression and apoptosis in LS 180 colon carcinoma cells.


    2522/2523

    Tytuł oryginału: Quantity examination of E6 and E7 proteins of HPV 18 in HeLa cell line incubated with retinoid acid.
    Autorzy: Dziubińska-Parol Izabela, Gąsowska Urszula, Rzymowska Jolanta, Wojcierowski Jacek, Kwaśniewska Anna
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.191-195, il., tab., bibliogr. 16 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The aim of this study was to measure the E6 and E7 proteins content in cells of HeLa cell lines incubated with retinoid acid. Quantity was compared with control to find out if there is a significant increase or decrease. Retinoid acid was added to cell lines in concentrations of 1ćM and 1 nM and the cells were incubated for 24 hours. E6 and E7 antigens were detected using DAKO LSAB+ System and extinction of the cells was measured. The results have shown that retinoid acid influenced both HPV 18 transforming proteins only in the concentration of 1 ćM. Althrough there was the decrease of extinction of cells incubated with 1nM concentration, it did not appear to have been significant.


    2523/2523

    Tytuł oryginału: Urology : urological oncology : neoplasms of the kidney, ureter and urinary bladder
    Opracowanie edytorskie: Lorenz Jerzy (ed.), Dembowski Janusz (ed.), Zdrojowy Romuald (ed.).
    Źródło: - Wrocław, Dolnośląskie Wydaw. Edukacyjne 2002, 153 s. : tab., bibliogr. [przy rozdz.], 24 cm.
    Sygnatura GBL: 736,979

    Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

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