Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ZLOTTA
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku

1/1

Tytuł oryginału: Complexed prostate-specific antigen, complexed prostate-specific antigen of total and transition zone, complexed/total prostate-specific antigen ratio, free-to-total prostate-specific antigen ratio, density of total and transition zone prostate-specific antigen: results of the prospective multicenter european trial.
Autorzy: Djavan Bob, Remzi Mesut, Zlotta Alexandre R., Ravery Vincent, Hammerer Peter, Reissigl Andreas, Dobroński Piotr, Kaisary Amir, Marberger Michael
Źródło: Urology 2002: 60 (4a) suppl. s.4-9, tab., bibliogr. 30 poz.
Sygnatura GBL: 312,634

Hasła klasyfikacyjne GBL:
  • onkologia
  • urologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska

    Streszczenie angielskie: This prospective, multicenter European Prostate Cancer Detection study evaluated the value and performance of the molecular forms of prostate-specific antigen (PSA) and their derivatives in combinantion with prostate gland and transition zone volumes in early detection of prostate cancer in patients with PSA levels between 4 and 10 ng/mL. Of 750 men enrolled at 7 different European urology centers into the study between November 2001 and March 2002, 340 (45.3 p.c.) had a total PSA (tPSA) between 4 and 10 ng/mL (age range, 46 to 87 years). In all patients, the ratio of complexed PSA (cPSA) to tPSA (c/tPSA), cPSA density (cPSAD), cPSAD of the transition zone, PSA, free (fPSA), ratio of fPSA to tPSA (f/tPSA), tPSA density (PSAD), and PSAD of the transition zone were measured and collected 5 to 10 minutes before the sextant biopsy with 2 additional transition zone cores. Measurements of tPSA and fPSA were done with the AxSYM test, whereas cPSA was measured with the ACS 180 cPSA assay. All patients had a transrectal ultrasound-guided sextant prostate biopsy, and 2 additional transition zone bipsies and total and transition zone volumes were measured at the time of biopsy. Histopathologic findings revealed benign in 237 patients and prostate cancer in 103 patients (69.7 p.c. and 30.3 p.c., respectively). Statistically significant differences included larger total volumes, larger transition zone volumes, and f/tPSA in patients with benign disease (P = 0.0009, P 0.0001, P 0.0001, respectively). At 90 p.c. and 95 p.c. sensitivity, specificity of cPSA was significantly...

    stosując format: