Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Lactoferrin immunomodulation of DTH response in mice.
Autorzy: Actor Jeffrey K., Hwang Shen-An, Olsen Margaret, Zimecki Michał, Hunter jr Robert L., Kruzel Marian L.
Źródło: Int. Immunopharmacol. 2002: 2 (4) s.475-486, il., tab., bibliogr. 51 poz.
Sygnatura GBL: 313,577

Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Improved nontoxic adjuvants, especially adjuvants capable of inducing cell-mediated immunity (CMI), are needed for research in immunology and for development of human and veterinary vaccines. Bovine Lactoferrin, an effector molecule shown to directly participate in host defense, was assessed at various concentrations as an adjuvant component for induction of DTH responses to sheep red blood cells (SRBC). Subcutaneous immunization with Lactoferrin enhanced delayed type hypersensitivity (DTH) in CBA mice in a dose-dependent fashion; DTH responses were most significantly increased when sensitization was accomplished using Lactoferrin at 50 ćg/dose and 250 ćg/dose. Furthermore, Lactoferrin admixed with suboptimal dose of SRBC enhanced DTH responses by over 17-fold. Peritoneal cells collected from mice intraperitoneally injected with a 100 ćg/dose of Lactoferrin demonstrated modest, but significant, production of TNF-ŕ, IL-12 and MIP-1ŕ, when cultured in vitro, compared to saline-injected controls. J774A.1 murine macrophages stimulated with Lactoferrin resulted in increased TNF-ŕ protein production, and upregulated IL-12 and IL-15 mRNA. Levels of message for chemokins MIP-1ŕ and MIP-2 were also increased in a dose-dependent way. Taken together, these results indicate that Lactoferrin as an adjuvant may stimulate macrophages to generate a local environment likely to push immune responses towards development and maintenance of CMI.


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    Tytuł oryginału: Rola laktoferyny w immunoregulacji ustroju oraz perspektywy zastosowania w terapii.
    Tytuł angielski: The role of lactoferrin in the immunoregulation and perspectives of its application in therapy.
    Autorzy: Zimecki Michał
    Źródło: Dział. Nauk. PAN 2002 (13) s.117-118, il., bibliogr. 3 poz., sum.
    Sygnatura GBL: 801,551

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja


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    Tytuł oryginału: Lactoferrin and immunologic dissonance: clinical implications.
    Autorzy: Kruzel Marian L., Zimecki Michał
    Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.399-410, il., tab., bibliogr. 84 poz.
    Sygnatura GBL: 304,223

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • in vitro

    Streszczenie angielskie: Homeostasis is the maintenance of equilibrium in a biological system by means of positive and negative feedback control mechanisms that counteract influences tending toward physiological dissonance. At the molecular level, homeostasis is controlled by the network of the neuro-endocrine-immune system, in which lactoferrin (LF) plays a central role. The purpose of this review is to provide a comprehensive summary of a collaborative study established between the Hirszfeld Institute of Immunology and Experimental Therapy (Wrocław, Poland) and the University of Texas Helth Science Center (Huston USA) regarding LF and its role in homeostasis. In our studies we focused on the immunoregulatory functions of LF, both in vitro and in vivo. We investigated the immune status of individuals subjected to different isults, including experimental endotoxemia in mice and surgery in humans. We also studied a LF-dependent delayed type hypersensitivity (DTH) response to evaluate some of the mechanisms by which LF can effectively substitute an adjuvant in vaccine.


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    Tytuł oryginału: The adjuvant activity of lactoferrin in the generation of DTH to ovalbumin can be inhibited by bovine serum albumin bearing ŕ-D-mannopyranosyl residues.
    Autorzy: Kocięba Maja, Zimecki Michał, Kruzel Marian, Actor Jeffrey
    Źródło: Cell. Mol. Biol. Lett. 2002: 7 (4) s.1131-1136, il., bibliogr. 6 poz.
    Sygnatura GBL: 306,513

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Lactoferrin (LF) is an iron-binding glycoprotein present in the cytoplasmic granules of neutrophils and in external secretions of mammals. Although the biological role of human and bovine lactoferrin has been extensively studied, there is still uncertainty as to the nature and function of lactoferrin receptors. We recently determined that methyl-ŕ-D-mannopyranoside given intraperitoneally (i.p.) could suppress the adjuvant activity of LF in the generation of delayed-type hypersensitivity (DTH) to ovalbumin (OVA). We concluded that the lactoferrin effects in DTH are mediated by carbohydratrecognizing receptors like the mannose receptor (MR). This study indicates that subcutaneous (s.c.) administration of very small doses of the Man-bovine serum albumin (Man-BSA) complex, together with a sensitizing dose of the antigen, gives the same effects as i.p. administration of methyl-ŕ-D-mannopyranoside. The latter is aso a blocker of MR, although of a much lower affinity to the ereceptor than Man-BSA. The blocking of the adjuvant effect of LF by the Man-BSA complex (when given together with the sensitising dose of antigen) suggests that the function of antigen-presenting cells in the skin (presumably) immature dendritic cells expressing MR) is inhibited. The results of our study indicate that a receptor with an affinity for mannose is essential for the mediation of adjuvant lactoferrin function in th egeneration of DTH.

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