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Tytuł oryginału: F2-isoprostanes biomarkers of lipid peroxidation: their utility in evaluation of oxidative stress induced by toxic agents.
Autorzy: Piłacik Bożena, Wrońska-Nofer Teresa, Wąsowicz Wojciech
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (1) s.19-27, il., bibliogr. 74 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: Isoprostanes are prostaglandin-like compounds that are produced by free radical mediated peroxidation of polyunsaturated fatty acids. There is a direct evidence showing that F2-isoprostanes can be utilized as a marker of lipid peroxidation due to the mechanism of their foramtion (nonenzymatic exidation of arachidonic acid), chemical stability, sensitive and non-invasive methods of their estiamtion. An altered generation of F2-isoprostanes has been found in a variety of pathological syndromes associated with oxidative stress. Their quantification allows to elucidate the role of free radicals in oxidative injury. This paper reviews briefly the recent data on isoprostanes: biochemical mechanisms of their formation, methods of their measurement, and the possibilities of their utilization as a quantitative/qualitative marker of oxidative stress in vivo.

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