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Tytuł oryginału: Molecular biology of prions.
Autorzy: Weissmann Charles, Enari Masato, Kl”hn Peter Christian, Rossi Daniela, Flechsig Eckhard
Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.153-166, il., tab., bibliogr. [111] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:
  • neurologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in they are transmissible, not only experimentally but also by natural routes, mainly by ingestion. The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistence to conventional sterilisation procedures, and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals in cell culture.

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