Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: WŁODEK
Liczba odnalezionych rekordów: 4



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Tytuł oryginału: Biologiczne właściwości kwasu liponowego.
Tytuł angielski: Biological properties of lipoic acid.
Autorzy: Bilska Anna, Włodek Lidia
Źródło: Post. Hig. 2002: 56 (2) s.201-219, il., tab., bibliogr. [67] poz., sum.
Sygnatura GBL: 301,727

Streszczenie angielskie: Lipoic acid is a prostetic group of H-protein of the glycine cleavage system and the dihydrolipoamide acyltransferases (E2) of the pyruvate, ŕ-ketoglutarate and branched-chain ŕ-keto acid dehydrogenase complexes. Lipoic acid and its reduced form, dihydrolipoic acid, reacts with oxygen reactive species. This paper reviews the beneficial effects in oxidative stress models or clinical conditions.

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Tytuł oryginału: Beneficial and harmful effects of thiols.
Autorzy: Włodek Lidia
Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.215-223, il., bibliogr. 47 poz.
Sygnatura GBL: 313,156

Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Biothiols are extraordinarily efficient antioxidants protecting the cells against conseuences of damage induced by free radical, due to their ability to react with the latter. In such antioxidant reactions, thiols undergo oneelectron oxidation with the formation of thiyl radicals. For this reason, attention has been focused mostly on antioxidant properties of thiols. Considerably less attention has been paid to thiyl radicals (RS) formed simultaneously in these reactions. However, protective and repairing efficacy of thiols depends not only on their capacity to detoxify free radicals but also on chemical character and reactivity of the formed thiyl radical. Furthermore, quick and efficient removal of RS radical leads to disturbance in balanced state of antioxidant reaction, which effectively increases repairing capacity. Dangerous thiyl radicals, which can cause peroxidative injury, should immediately undergo regenerative reduction to thiols. Under physiological conditions, thiyl radicals can react with thiolate anion yielding disulfide radical anion (RSSR) as an intermediate and finally disulfides and superoxide radical anion (O2), which is next inactivated in teh reaction catalyzed by superoxide dismutase (SOD). Thiyl radicals can also be reduced to thiols by reacting with ascorbate with the formation of low-activity ascorbyl radical, that subsequently enters disproportiation reaction.

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    Tytuł oryginału: The ç-glutamyltransferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups.
    Autorzy: Włodek Przemysław, Sokołowska Maria, Smoleński Olgierd, Włodek Lidia
    Źródło: Acta Bioch. Pol. 2002: 49 (2) s.501-507, il., bibliogr. s. 506-507
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: The present work was aimed to obtain information about age-dependent changes of ç-glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl compounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated. The results indicate that the activity of GGT and NPSH levels in the kidneys are reduced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the oldest animals. These findings indicate that the capacity for extracellular glutathione degradation adn, in consequence, the availability of cysteine for intracellular glutathione biosynthesis may be impaired. The increased PB-Cys level indicates potentiation of the thiolation reaction, i.e. development of protein-mixed disulfides. These results reveal age dependent disturbances in the thiol-disulfide equilibrium in the dineys which leads to an imbalance between pro- and antioxidatory processes.

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    Tytuł oryginału: Sulfurtransferases activity and sulfane sulfur level in cells of the immune system. Preliminary report.
    Autorzy: Wróbel Maria, Grabowska Agnieszka, Włodek Lidia, Czubak Jerzy, Marcinkiewicz Janusz
    Źródło: Centr. Eur. J. Immunol. 2002: 27 (1) s.35-40, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,243

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: The activity of rhodanese, cystathionase and 3-mercaptopyruvate sulfurtransferase (MPST), participating in L-cysteine desulfuration, and the level of sulfane sulfur, a product of the process, were determined in murine peritoneal macrophages, bone marrow derived dendritic cells, lymph node lymphocytes, and in macrophage type cell line - J774. Among all the investigated cells, the highest value of MPST activity was detected in the lymphocytes, what - together with the estimated high level of sulfane sulfur-containing compounds - may correlate with the high rate of DNA synthesis and proliferation, characteristic of these cells. Dendritic cells, in turn, showed the highest cystathionase activity and a relatively high MPST and rhodanese activity, but surprisingly, sulfane sulfur was not detected. It would be interesting to explain whether these antigen presenting dendritic cells release sulfane sulfur-containing compounds to stimulate lymphocyte proliferation. In peritoneal macrophages, a relatively high activity of MPST and rhodanese and a high level of sulfane sulfur compounds may provide the pretection against reactive oxygen species produced after their activation. It was also observed that mouse macrophage cell line presented a significantly lower activity of MPST and rhodanese and a lower level of sulfane sulfur in comparison to mouse peritoneal macrophages.

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