Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: TAUTT
Liczba odnalezionych rekordów: 3



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku
1/3

Tytuł oryginału: New renin inhibitors with pseudodipeptidic units in P1-P1' and P2'-P3' positions.
Autorzy: Paruszewski Ryszard, Jaworski Paweł, Winiecka Iwona, Tautt Jadwiga, Dudkiewicz Jadwiga
Źródło: Chem. Pharm. Bull. (Tokyo) 2002: 50 (6) s.850-853, tab., bibliogr. 21 poz.
Sygnatura GBL: 304,601

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A series of four new potential renin inhibitors has been synthesized. The structure of the compounds was designed in such a way as to produce agents resistant to enzymatic degradation, metabolically stable, possibly potent and with improved oral absorption. All positions of the 8-13 fragment of the human angiotensinogen were occupied by unnatural units (two unnatural amino acids in position P3 and P2 and two pseudodipeptides in positions P1-P1, and P2-P3,). Both N- and C-terminal functions of the inhibitors were blocked with tert-Boc and ethyl ester groups. Their hydrophobicity evaluated as a log P value, calculated by a computer method, was 6.57 and 6.08 respectively. All peptides were obtained by the carbodiimide method in solution and purified by chromatography on the SiO2 column. Their resistance to enzymatic degradation was assayed by determination of stability against chymotrypsin activity. The potency was measured in vitro by a spectrofluorimetric method (assay of Leu-Val-Tyr-Ser released from the N-acetyltreadecapeptide substrate by renin in the presence of the inhibitor). All inhibitors were stable to chymotrypsin. Their IC50 (M/I) values were: 9.6 x 10**-4 (12), 1.6 x 10**-5 (17), 1.0 X 10**-5 (22) and 1.0 x 10**-5 (23) respectively.

    2/3

    Tytuł oryginału: Application of high-performance size exclusion chromatography to the determination of erythropoietin in pharmaceutical preparations.
    Autorzy: Dudkiewicz-Wilczyńska Jadwiga, Snycerski Andrzej, Tautt Jadwiga
    Źródło: Acta Pol. Pharm. 2002: 59 (2) s.83-86, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: High performance size exclusion chromatography with fluorimetric detection for the determination of erythropoietin in pharmaceutical preparations has been developed. The applied chromatographic system has been enabled a quick estimation of the identity and contents of the studied compound. The method was validated and showed good validation data in terms of lineary, precision and repeatability. The validated method was successfully applied to the determination of erythropoietin content in commercially available preparations.

    3/3

    Tytuł oryginału: Determination of the content of desmopressin in pharmaceutical preparations by HPLC and validation of the method.
    Autorzy: Dudkiewicz-Wilczyńska Jadwiga, Snycerski Andrzej, Tautt Jadwiga
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.163-168, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The aim of this study was to apply high performance liquid chromatography to the determination of content of desmopressin in pharmaceutical preparations and validation of the method. The satisfactory results have been obtained using a column Luna C 8.5 ćm, 100 x 4.6 mm and a mobile phase containing 0.067 M phosphate buffer of pH = 7 and acetonitrile in the proportion 83 : 17. It has been shown that the elaborated method shows good precision and accuracy and can be applied to the qualitative and quantitative analysis of pharmaceutical preparations containing desmopressin.

    stosując format: