Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
SULKOWSKI
Liczba odnalezionych rekordów:
3
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1/3
Tytuł oryginału:
Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus.
Autorzy:
Pawlak
Robert,
Skrzypiec
Anna,
Sulkowski
Stanisław,
Buczko
Włodzimierz
Źródło:
Neurosci. Lett. 2002: 327 (2) s.83-86, il., bibliogr. 19 poz.
Sygnatura GBL:
305,936
Hasła klasyfikacyjne GBL:
toksykologia
neurologia
Typ dokumentu:
tytuł obcojęzyczny
praca opublikowana za granicą
praca doświadczalna
Wskaźnik treści:
zwierzęta
myszy
Streszczenie angielskie:
Chronic ethanol abuse leads to degenerative changes in the hippocampus, which may result in subsequent cognitive impairment. Since the hippocampus retains the ability to produce neurons throught adulthood, in the present study we examined if ethanol-induced neuronal loss could be counterbalanced by cell proliferation in mouse dentate gyrus (DG). A total of 14 days of ethanol administration resulted in marked increase in cells positive for TdT-mediated dUTP nick-end labeling in all hippocampal regions studied, indicating that neurons die throughout the hippocampus by apoptotic mechanism. However, cresyl violet staining revealed approximately 20 p.c. neuronal loss following ethanol administration in CA1 and CA2 fields (P 0.01 and P 0.05, respectively), but not in DG. At the same time ethanol caused 2-fold increase in the number of proliferating cells in subgranular zone of DG. Thus, long-term ethanol intoxication causes permanent damage to CA1 and CA2, but not to DG which can be counterbalanced by ongoing neurogenesis.
2/3
Tytuł oryginału:
The expression of tumorigenesis markers in oral papilloma.
Autorzy:
Reszeć
Joanna,
Sulkowska
Mariola,
Famulski
Waldemar,
Guzińska-Ustymowicz
Katarzyna,
Sulkowski
Stanisław
Źródło:
Pol. J. Pathol. 2002: 53 (4) s.195-200, il., tab., bibliogr. 34 poz.
Sygnatura GBL:
301,852
Hasła klasyfikacyjne GBL:
stomatologia
pediatria
onkologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dzieci 2-5 r.ż.
dzieci 6-12 r.ż.
dzieci 13-18 r.ż.
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
Oral papilloma is the most frequent benign tumor of the oral cavity but its biological potential for malignant transformation is still to be evaluated. The alteration of apoptosis and uncontrolled cell proliferation is considered to be an important factor in oral tumorigenesis. The aim of our study was to evaluate by immunohistochemistry P53, Bcl-2, CD44 and PCNA expression in oral papillomas with and wityout dysplasia. We examined a series of 55 oral papillomas, including 12 (21.8 p.c.) cases of papillomas with epithelial dysplasia. Staining patterns were correlated with sex, age, tumor location, size and presence or absence of epithelial dysplasia. P53 showed positive reaction in 70.9 p.c. PCNA in 80 p.c., CD44 in 50.9 p.c. and Bcl-2 in 21.8 p.c. of papillomas. Ther was no correlation between sex, age, tumor size, location and presence of dysplastic epitehelium in papillomas. We observed a statistically significant correlation between Bcl-2, CD44 expression and presence of epithelial dysplasia in papillomas. Coexistence of PCNA and P53 positive immunostaining was observed. Papillomas with overexpression of P53 adn PCNA showed negative reaction for CD44 protein. The results of our study suggest that overexpression of P53 and PCNA might be an early event in oral tumorigenesis, whereas CD44 and Bcl-2 are potential markers of epithelial dysplasia in oral papillomas.
3/3
Tytuł oryginału:
Effect amifostine on lung oxidative stress after cyclophosphamide therapy.
Autorzy:
Stankiewicz
Anna,
Skrzydlewska
Elżbieta,
Sulkowska
Mariola,
Sulkowski
Stanisław
Źródło:
Bull. Vet. Inst. 2002: 46 (1) s.87-94, tab., bibliogr. 26 poz.
Sygnatura GBL:
304,313
Hasła klasyfikacyjne GBL:
weterynaria
toksykologia
farmacja
pulmonologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie angielskie:
The ability of amifostine to protect healthy rat lung cells from cyclophosphamide-induced injury was evaluated. It was shown that cyclophosphamide decreased the activity of superoxide dismutase, gluthatione reductase and catalase as well as the level of reduced gluthatione, vitamin C and total antioxidant status and increased lipid peroxidation measured as malondialdehyde. Amifostine alone did not change or cause the increase in the antioxidative parameters and decrease in lipid peroxidation. Amifostine with cyclophosphamide only partially prevented changes in lung cells caused by cyclophosphamide.
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