Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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SIERZEGA
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Tytuł oryginału:
Long-term results of surgery for early gastric cancer.
Autorzy:
Popiela
T.,
Kulig
J.,
Kołodziejczyk
P.,
Sierzega
M.
Źródło:
Br. J. Surg. 2002: 89 (8) s.1035-1042, il., tab., bibliogr. 47 poz.
Sygnatura GBL:
310,131
Hasła klasyfikacyjne GBL:
chirurgia
onkologia
gastroenterologia
Typ dokumentu:
praca kliniczna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 45-64 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
Bacground: Gastrectomy for early gastric cancer, is widely accepted as an adequate therapeutic method. Recent developments of less invasive procedures require the identification who will benefit from such an approach. Methods: A retrospective study was undertaken of 238 patients with early gastric cancer who underwent gastrectomy from 1977 to 1999. Clinicopathological data relating to survival were evaluated. Results: Analysis of 33 node-positive patients (14 per cent) revealed a tumour diameter greater than 20 mm (P = 0.011), depressed macroscopic type (P 0.05), diffuse histological type (P 0.001), poor tumour differentiation ( P 0.001) and infiltration of the submucosal layer (P 0.002) as factors assopciated with lymph node metastasis. Multivariate analysis found diffuse histological type to be an independent risk factor. The overall 5-year survival rate was 87 p.c., and was significantly better in patients who underwent radical lymphadenectomy than in those who had regional lymph node dissection (92 versus 78 p.c.; P 0.01). Similarly, patients younger than 65 years had a more favourable 5-year survival rate (90 p.c.) than oder ones (77 p.c.). Multivariate analysis with the Cox proportional hazards model confirmed patient age and type of lymphadenectomy as independent prognostic factors. Conclusion: The findings suggest that extended lymph node dissection may be beneficial for some patients with early cancer, althoug randomized clinical trials are needed to evaluate this observation further.
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