Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: SCHR”DER
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Induction of long term peripheral microchimerism in non-human primates in a model of xenogeneic peripheral tolerance induction.
Autorzy: Simon A. R., Schr”der C., Martin U., Tessmann R., Templin C., Laaf G., Wiebe K., Steinhoff G., Lapin B., Chikobava M., Haverich A.
Źródło: Ann. Transplant. 2002: 7 (3) s.40-45, il., tab., bibliogr. 15 poz.
Sygnatura GBL: 313,259

Hasła klasyfikacyjne GBL:
  • transplantologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • małpy
  • Świnie

    Streszczenie angielskie: Xenotransplantation represents a promising solution to the ever increasing shortage of donor organs in allotransplantation. However, due to different and stronger models of rejection, successful xenotransplantation will require different organ-protective regimes from those used in allogenic transplantation today. Since one can simply increase the dosage of the drugs used, immunomodulation or tolerance induction of the recipient would be the most desirable approach. Transfusion of donor leukocytes has been shown to downregulate recipient responses or even induce peripheral tolerance in small animal models. Since the infusion of donor cells represents a relatively simple approach, as one can purify and compose the inoculum exactly before infusion, we studied whether this approach can be successfully employed in a preclinical swine to nonhuman primate model of peripheral tolerance induction/immunomodulation. In our model, baboons underwent sequential column adsorption and complement blockade. The animals received only initial immunosuppression with cyclophosphamide. No further immunosuppression was given. Subsequently all animals received 1-3x10**10 porcine splenocytes i.v. Development and maintainance of chimerism was analyzed by sequential flow cytometric and PCR analyses. Other parameters studied included effects of the preparatory induction protocol. We could show that a low level of chimerism is maintained in these animals for up to 1,5 years, despite the fact that they received no additional immunosuppression after the initial one. At no time of the experiment did any animal...


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    Tytuł oryginału: Retrograde iliac endarterectomy - modified technique combining conventiomal surgical and interventional procedures.
    Autorzy: Schr”der Alfred, Mckner Kersten, Vogel Steffen
    Źródło: Acta Angiol. 2002: 8 (4) s.143-146, il., bibliogr. 6 poz.
    Sygnatura GBL: 313,274

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background. Retrograde ring-stripper endartectomy of iliac arteries throught an inguinal approach modified by combining interventiuonal procedures. Material and methods. 52 iliac arteries underwent modified retrograde ring-stripper endartectomy. Passage of the lesions with a giude wire permits endarterectomy over the wire as a central splint under fluoroscopic control. Resiudual lesions are corrected by ballon or stent angioplasty. Results. Conversion to a conventional operation was required in 8 limbs. Initial technical success was was achieved in 44 limbs. Cumulative secondary patience was 95.8 p.c. at 24 months (S.E. 4.7 p.c.). Conclusion. Modified ring-stripper endarectomy witrh angioplasty is a safe and effective procedure. Long-term results are reqiured.

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