Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Efficacy of psychiatric day hospital treatment: review of research findings and design of a European multi-centre study.
Autorzy: Kallert T[homas] W., Schtzwohl M., Kiejna A., Nawka P., Priebe S., Raboch J.
Źródło: Arch. Psychiatr. Psychother. 2002: 4 (2) s.55-71, tab., bibliogr. 75 poz.
Sygnatura GBL: 313,554

Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The paper presents a literature review of research findings on acute treatment in psychiatric day hospitals, and outlines the desing of an ongoing multi-site study on the effectiveness of acute day hospital treatment. The review is based on relevant older publications and recent randomised controlled trials comparing day hospital treatment with inpatient care. The findings suggest that (a) a wide range of patient groups are cared for in day hospitals, (b) both patients and their relatives assess day hospital treatment favourably, (c) treatment in day hospitals is at least as effective as inpatient care, and (d) day hospital treatment may lead to significant cost savings as compared to in-patient care. There are, however, a number of important questions that cannot be answered on the basis of the existing literature, and further research on the topic is warranted. The EDEN-study (European Day Hospital EvaluatioN) is a randomised controlled trial comparing day hospital treatment with conventional in-patient care and following the same protocol in five European countries (Czech Republic, Germany, Poland, Slovakia and United Kingdom). Aims and methods of the study are presented.

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    Tytuł oryginału: Syntezy naturalnych i modyfikowanych antybiotyków antracyklinowych ze wspólnego prekursora: 3,4-di-O-acetylo-L-ramnalu.
    Tytuł angielski: Syntheses of natural and modified anthracycline antibiotics from a common precursor: 3,4-di-O-acetyl-L-rhamnal.
    Autorzy: Grynkiewicz Grzegorz, Achmatowicz Osman, Fokt Iza, Priebe Waldemar, Ramza Jan, Szechner Barbara, Szeja Wiesław
    Źródło: Wiad. Chem. 2002: 56 (7/8) s.535-560, il., sum.
    Sygnatura GBL: 310,575

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna

    Streszczenie angielskie: While natural anthracycline antibiotics retain their possition of clinically important antitumor drugs despite their serious side effects, much effort is directed towards their improvement by rational structural changes. Most of useful anthracycline antibiotics chemistry is done by dissconnectionmodification approach, followed by de novo glycosidic bond assembly. It is pointed out that 1,2- and 2,3-unsaturated pyranosides constitute an important class of intermediates, useful for synthesis of natural and modified antibiotic aminosugars. Glycals derived from 3-amino-2,3,6-trideoxypyranoses and their 1-O-silylated derivatives are useful glycosyl donors for a variety of alcohols. Also anthracycline antibiotics can be obtained from them in simple preparative procedures which are amenable for scale up and technical process development. Moreover, unsaturated pyranoses from 6-deoxy-L-configurational series are useful chiral precursors for anthracycline aglycons synthesis. Remarkably, various synthetic schemes comprising anthracycline antibiotic sugars, aglycons and new synthetic analogues can be traced down to the single common precursor: 3,4-di-O-acetyl-L-rhamnal, easily obtained from a commodity chemical (raw material in food industry) L-rhamnose.

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