Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: PIETRUCHA-DUTCZAK
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Tytuł oryginału: Skrypt do ćwiczeń z fizjologii człowieka
Autorzy: Dąbek Józefa, Gołka Beata, Górka Dariusz, Larysz-Brysz Magdalena, Olakowska Edyta, Pietrucha-Dutczak Marita, Święch-Sabuda Ewa, Wolwender Katarzyna, Woszczycka-Korczyńska Izabella
Opracowanie edytorskie: Lewin-Kowalik Joanna (red.).; Śląska Akademia Medyczna w Katowicach
Źródło: - Katowice, ŚAM 2002, 137 s. : il., tab., 24 cm.
Sygnatura GBL: 735,910

Wskaźnik treści:
  • ludzie

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    Tytuł oryginału: Pre-degenerated peripheral nerve extracts applied to the proximal stump of transected sciatic nerve enhance both regeneration and autotomic behavior in rats.
    Autorzy: Lewin-Kowalik Joanna, Marcol Wiesław, Larysz-Brysz Magdalena, Wolwender Katarzyna, Pietrucha-Dutczak Marita, Górka Dariusz
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR414-BR420, il., bibliogr. 42 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: Peripheral nerve regeneration after traumatic injury and standard repair with a nerve autograft is often incomplete and results in neuropathic pain. Peripheral nerve extracts applied to the proximal nerve stump by means of autologous, dead-ended connective tissue chambaers (deCTC) are known to accelerate the rate of acon regeneration. This study tested if such extracts would influence autotomy, which is a behavioral measure of neuropathic pain in animal models. Material/Methods: The study was performed on Wistar rats. DeCTCs, filled with postmicrosomal fraction obtained from 7-day-predegenerated nerves (7D group) or fibrin (F group), were implanted into transected sciatic nerve. In the control group (C), sciatic nerve was transected and its distal part was removed. The self-mutilation behavior in rats was assessed daily for seven weeks after sciatic nerve transcetion. The onset as well as intensity of autotomy was measured. The progress of regeneration was assessed under light microscopy and histochemistry. Results: The earliest onset and gratest severity of autotomy were found in teh 7D group. Regeneration progress was also highest in this group. In the F group, we found weaker regeneration and less autotomy. The control group showed no regeneration, but more autotomy than the F group. Conslusion: Intensifeid autotomy may be teh price paid for enhanced peripheral nerve regeneration after application of growth-promoting substances.

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