Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: PICHA
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4.
Autorzy: Wójcikowski Jacek, Pichard-Garcia Lydiane, Maurel Patrick, Daniel Władysława A.
Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.407-410, il., bibliogr. 10 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca kazuistyczna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The effects of perazine on the activities of CYP1A2 and CYP3A4 in a primary culture of human hepatocytes of one patient were studied in vitro. The CYPs activities were assessed by measuring the rate of acetanilide 4-hydroxylation (CYP1A2) and cyclosporine A oxidation (CYP3A4) after treatment with TCDD (a CYP1A subfamily inducer) or rifampicin (mainly a CYP3A4 inducer). The amounts of the metabolities formed in hepatocytes were assayed in the extracellular medium using the HPLC method. TCDD and rifampicin induced the formation of 4-hydroxyacetanilide and cyclosporine A metabolities (monohydroxycyclosporine A, dihydroxycyclosporine A, N-desmethylcyclosporine A), respectively. The formation of 4-hydroxyacetanilide was strongly inhibited by three different concentrations of perazine (10, 25 and 50 ćM) reaching 8,3 and 2 p.c. of the control value, respectively. In the case of CYP3A4 activity, no such an effect of perazine was observed. Perazine showed only a week inhibition of the activity of cyclosporine A oxidase (to 96-86 p.c. of the control value). The obtained results suggest a strong inhibitory effect of perazine on human CYP1A2 activity with predicted Ki value similar to those of the known for CYP1A2 inhibitors, such as furafylline and fluvoxamine.

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    Tytuł oryginału: Literatura medyczna w zbiorach cieszyńskich lekarzy i farmaceutów w XVIII/XIX w. Na podstawie zapisów proweniencyjnych w Bibliotece Leopolda Jana Szersznika w Cieszynie.
    Tytuł angielski: Medical literature in the collections of 18th-19th Century doctors and pharmacists in Cieszyn, on the basis of records kept at the Leopold Jan Szersznik Library in Cieszyn.
    Autorzy: Sztuchlik Jolanta, Picha Jadwiga
    Źródło: Med. Nowoż. 2002: 9 (1/2) s.165-176, sum., Zsfg
    Sygnatura GBL: 306,463

    Typ dokumentu:
  • praca historyczna

    Wskaźnik treści:
  • historia nowożytna
  • historia XVIII wieku
  • historia XIX wieku

    Temat korporatywny:
  • Śląsk

    Streszczenie angielskie: The L. J. Szersznik Library was founded in Cieszyn in 1802. It was formed out of the bool collection of I. J. Szersznik, a citizen of Cieszyn who was principal of the Catholic grammar school in Cieszyn from 1786. Today the library has about 15.000 volumes, catalogued according to 27 thematic groups. The Medici section has about 380 medical works which once belonged to Szersznik and other citizens of Cieszyn - doctors, pharmacists, burgesses and noblemen. The article provides their names and the titles and descriptions of some of the medical works that form part of the collection, together with a brief outline of their history, the biographies of their authors, and general content of the publication. In this way it provides information on the medical knowledge of Cieszyn doctors on the threshold of the 18th and 19th centuries.

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