Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: PECZYŃSKA-CZOCH
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Synthesis of 6-substituted 6H-indolo[2,3-b]quinolines as novel cytotoxic agents and topoisomerase II inhibitors.
Autorzy: Kaczmarek Łukasz, Łuniewski Wojciech, Zagrodzki Bogdan, Godlewska Joanna, Osiadacz Jarosław, Wietrzyk Joanna, Opolski Adam, Peczyńska-Czoch Wanda
Źródło: Acta Pol. Pharm. 2002: 59 (3) s.199-207, il., tab., bibliogr. 8 poz.
Sygnatura GBL: 301,378

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: A systematic investigation into the impact of the substituents introduced into the indolo[2,3-b]quinoline system is described. The findings clearly demonstarte that the compounds bearing a methyl group or a longer aliphatic chain at the N-6 position are inactive against prokaryotic and eukaryotic cells. The indroduction of alkyl-amino-alkyl substituent at the N-6 position of indolo[2,3-b]quinoline accounts for the appearance of the antimicrobial and cytotoxic properties. The cytotoxicity against oral epidermoid carcinoma KB(ID50) is in the range from 2.0 to 9.0 ćM, and the antimicrobial activity (MIC) falls between 0.003 and 0.50 mM. The structural relation within 6H-indolo[2,3-b]quinolines, concering their antimicrobial and cytotoxic activity, corresponds well with their ability to bind DNA and to inhibit topoisomerase II activity.

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    Tytuł oryginału: Poliaminy i ich udział we wzroście nowotworów.
    Tytuł angielski: Polyamines and their role in tumour growth.
    Autorzy: Godlewska Joanna, Peczyńska-Czoch Wanda
    Źródło: Post. Hig. 2002: 56 (6) s.757-777, il., bibliogr. s. 774-776, sum.
    Sygnatura GBL: 301,727

    Hasła klasyfikacyjne GBL:
  • onkologia

    Streszczenie angielskie: The polyamines - putrescine, spermidine and spermine - are normal constituents of prokariotic and eukariotic cells. These small polycationic, aliphatic compounds are essential for normal cell proliferation. Cells cease to proliferate, when they are depleted of their polyamines, but resume a normal growth rate after supplementation with these compounds. Because of the sustained increase in polyamine biosynthesis in preneoplastic and neoplastic tissues, a great deal of interest has been given to the polyamine biosynthesis, network, and uptake systems as a target in antineoplastic strategies.

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