Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: PAWLICZAK
Liczba odnalezionych rekordów: 4



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Tytuł oryginału: Decreased apoptosis and distinct profile of infiltrating cells in the nasal polyps of patients with aspirin hypersensitivity.
Autorzy: Kowalski M. L., Grzegorczyk J., Pawliczak R., Kornatowski T., Wagrowska-Danilewicz M., Danilewicz M.
Źródło: Allergy 2002: 57 (6) s.493-500, il., tab., bibliogr. 49 poz.
Sygnatura GBL: 302,302

Hasła klasyfikacyjne GBL:
  • toksykologia
  • immunologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Patients with aspirin-hypersensitive rhinosinusitis/asthma suffer from a severe form of hyperplastic rhinosinusitis with recurrent polyposis. We aimed to assess the presence of apoptotic cells in nasal polyps from aspirin-hypersensitive (AH) and aspirin-tolerant (AT) patients with rginosinusitis as related to the characteristis of local inflammation. Methods: Nasal polyps obtained from 16 AH patients and 36 AT patients (17 atopic and 19 nonatopic) were stained for eosinophils and metachromatic cells, and in parallel immunocytochemistry was performed to detect CD45RO+, HLA-DR+, CD8+ and CD68+ positive cells. Apoptotic cells were detected by a nick-end labelling technique, TUNEL. Results: The density of apoptotic cells in AH polyps (5.5 + 1.5 cells/mmý) was significantly lower as compared to both atopic (18.7 + 3.8 cells/mmý; P 0.02;) and nonatopic (21.3 + 5.2 cells/mmý; P 0.01) AT polyps. The number of eosinophils, mast cells, and CD45RO+ cells weer significantly increased in AH compared to AT polyps () 0.001), and the density of HLA-DR+ cells in AH patients was higher than in nonatopic (P 0.02), but not in atopic AT patients. While in AH patients the duration of rhinosinusitis correlated inversely with the number of apoptotic cells (r = - 0.67; P 0.04), in contrast, in AT atopic patients the duration of rhinosinusitis showed positive correlation with apoptosis (r = 0.89; P 0.003). Conclusions: We conclude, that decreased apoptosis of inflammatory cells in nasal polyps from ASA-hypersensitive patients, reflects a distinct mechanism of local inflammation and may be related to persistence and severity of the disease in these patients.

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    Tytuł oryginału: Porfiria skórna późna u chorej na przewlekłą niewydolność nerek leczonej zabiegami hemodializ - opis przypadku.
    Tytuł angielski: Dermatosis bullosa in a patient with chronic renal failure under hemodialysis treatment - case report.
    Autorzy: Wanic-Kossowska Maria, Furmanowska Anna, Pawliczak Elżbieta, Kozioł Lidia, Bajew Liliana, Kobelski Mikołaj, Czekalski Stanisław
    Źródło: Pol. Arch. Med. Wewn. 2002: 108 (1) s.671-674, bibliogr. 22 poz., sum.
    Sygnatura GBL: 313,501

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia
  • nefrologia

    Typ dokumentu:
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie polskie: W pracy przedstawiono przypadek 45-letniej chorej z przewlekłą niewydolnością nerek leczonej zabiegami hemodializ, u której wystąpiły zmiany skórne typowe dla porfirii skórnej późnej. Rozpoznanie ustalono na podstawie badania klinicznego oraz na podstawie badania histopatologicznego wycinka skóry. Stwierdzano ponadto mierną nadwrażliwość skóry na promienie UVA, w surowicy wykazano znacznie podwyższone stężenie glinu i ołowiu. Nie stwierdzono obecności porfiryn w moczu (zbiórka dobowa 100 ml) i w płynie dializacyjnym.

    Streszczenie angielskie: A case of 45-year -old patient with chronic renal failure treated by hemodialysis associated with skin changes typical for porphyria cutanea tarda is reported. The diagnosis was based on clinical manifestations and on histopathologic examination of the skin segment. The skin was low sensitive for UVA rays, serum levels of aluminium and lead were significantly elevated. We did not find porphyrins in the urine (24-hour collection 100 ml) as well as in the dialysis fluid.

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    Tytuł oryginału: Prolongation of rat kidney graft survival after inoculation of allogeneic spleen cells: the effect of various routes of cell transfer.
    Autorzy: Oko Andrzej, Idasiak-Piechocka Ilona, Pawlaczyk Krzysztof, Wruk Michał, Pawliczak Elżbieta, Czekalski Stanisław
    Źródło: Ann. Transplant. 2002: 7 (2) s.51-53, tab., bibliogr. 17 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • nefrologia
  • transplantologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Objectives: It has been clearly demonstrated that after donor-specific cell transfer the prolongation of allograft survival can be obtained, but the problem of how to inoculate cells remains unresolved. In this study, the effect of either protal venous (PV) or systemic intravenous (IV) inoculations of rat donor-specific spleen cells on subsequent renal graft survival was evaluated. Methods: LEW recipients received 10**6 of spleen cells from allogeneic Fishcer or syngeneic donors 30 days before kidney transplantation by either PV or IV routes. Animals from the control group obtained buffered saline by the same routes. Results: Fischer grafts in nonimmunized LEW recipients were rejected after 9.6 ń 1.3 days. In contrast, the immunization of the recipients by the pretreatment with donor spleen cells prolonged renal allograft survival significantly (p 0.002). However, no difference in the graft survival was observed between animals ioculated with cells either by PV or by IV routes. In each studied group, long-time graft survival ( 100 days) was achieved in one case. Conclusions: These observations suggest that the effect of the various routes of allogeneic cell inoculations on subsequent organ graft survival time depends on the interval between the cell transfer and organ transplantation. Intravenous route seems to be as effective as PV route when transplantation is performed several days after donor-specific cell transfusion.

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    Tytuł oryginału: Analiza ekspresji genów w skali całego genomu - zastosowanie w naukach biologicznych i medycynie.
    Tytuł angielski: A genom - wide range analysis of gene expression - application in biological sciences and medicine.
    Autorzy: Pawliczak Rafał, Kowalski Marek L.
    Źródło: Post. Hig. 2002: 56 (4) s.537-553, il., tab., bibliogr. [55] poz., sum.
    Sygnatura GBL: 301,727

    Hasła klasyfikacyjne GBL:
  • genetyka

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Microarrays are one of the latest breakthroughs in experimental molecular biology, which allow monitoring of gene expression for tens of thousands of genes in partial and are already producing huge amounts of valuable data. Microrray RNA expression on a genome-wide range is now a proven technology, although the idea of analysis of expression many genes in one sample is not new. Since the development of clone printing technology and oligonycleotide synthesis allowed to produce high density microarray. In this publication we provide the information about the technology, available detection systems and data analysis software. Comprehensive review of current or fundamental papers using microrarray technology application in immunology, rheumatoid arthritis, oncology, cystis fibrosis research, primary pulmonary hypertension, psychiatry, and allergic airways inflammation is also included.

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